Life Sciences Commons^™

Maximising Slurry Crop Available Nitrogen Utilisation In Grassland Systems, J. R. Williams, E. Sagoo, B. J. Chambers, J. Laws, D. R. Chadwick

IGC Proceedings (1977-2023)

In the UK, approximately 90 million tonnes of animal manure containing ca 450,000 tonnes of nitrogen (N) are recycled to agricultural land each year. The efficient utilisation of manure N can save farmers money and reduce diffuse air (ammonia) and water (nitrate) pollution. For slurries, bandspreading techniques (e.g. trailing shoe and trailing hose) can improve N utilisation by reducing ammonia volatilisation losses compared with conventional broadcast applications. They also provide increased spreading opportunities in spring/summer as slurry is placed in a band on the soil surface limiting herbage contamination, which can reduce the need to apply slurry in the autumn/early …

Phosphorus Transfer To River Water From Grassland Catchments In Ireland, H. Tunney, P. Jordan, G. Kiely, R. Moles, G. Morgan, P. Byrne, W. Menary, K. Daly

IGC Proceedings (1977-2023)

In Ireland it is estimated that at least half of phosphorus (P) loss to water is from agricultural sources and National and European Union policy and legislation aim at reducing phosphorus (P) loss to water in order to reduce eutrophication. In Ireland, the average soil test P (STP) levels increased ten-fold, from less than 1 to over 8 mg Morgan P per l soil over the past 50 years, reflecting increased P inputs in fertiliser and animal feed. One of the main objectives of this three-year research programme, started in 2001, was to investigate P loss to water in grassland …

Denitrification Under Pastures On Permeable Soils Helps Protect Ground Water Quality, M. P. Russelle, B. A. Browne, N. B. Turyk, B. Pearson

IGC Proceedings (1977-2023)

Pastures have been implicated in ground water contamination by nitrate, especially in humid regions with thin or sandy soils (Stout et al., 2000). Significant losses can occur even under low N input, because available N from excreta patches often exceeds plant uptake capacity. Lack of evidence that appreciable nitrate leaching was occurring in established Midwestern USA pastures led us to test the hypothesis that denitrification was preventing or remediating nitrate loading. Higher denitrification rates have been found in the relatively limited number of trials since Ball & Ryden (1984) first reported the significance of this process in pastures.

Assessment Of Nitrogen Nutrition Status Of Grasses Under Water Deficit And Recovery, V. G. Dugo, Jean-Louis Durand, F. Gastal

IGC Proceedings (1977-2023)

Grasslands are rarely irrigated. They are therefore systematically submitted to more or less severe water deficits: as well as mineral deficiencies, water scarcity often also results in a reduction of nitrogen (N) status. Although identified some time ago, qualitatively, the interaction with N still remains difficult to take into account in quantitative analyses of crop physiology under water deficits. This paper illustrates how the nitrogen (N) status of the crop changes under water deficits. A N nutrition index (INN) was defined as the ratio of the actual N concentration of forage with the theoretical N concentration under optimal conditions, the …

Improving Nutrient Supply Of Grassland Soil, G. Füleky, M. Orbán

IGC Proceedings (1977-2023)

In the Southern corner of the Eastern Carpathian Mountains is located the hilly region of Barcaság. The total agricultural area is 180 thousand ha of which 90 thousand ha is grassland. The maximum yield of natural grassland does not exceed 1.2 t ha^-1 hay. The aim of this work is to find appropriate fertiliser and liming rates to increase the hay yield and improve the soil nutrient supply.

Safe - A Tool For Assessing The Sustainability Of Agricultural Systems: An Illustration, X. Sauvenier, C. Bielders, M. Hermy, E. Mathijs, B. Muys, J. Valckx, N. Van Cauwenbergh, M. Vanclooster, E. Wauters, A. Peeters

IGC Proceedings (1977-2023)

SAFE (Framework for Assessing Sustainability levels) is a tool for evaluating the sustainability of agricultural systems and uses a hierarchical framework populated with indicators objectively selected by multicriteria evaluation. Indicators are measured at field, farm and landscape scales and progressively integrated into a global sustainability index (SI). SAFE is illustrated below with results on a field scale from a farm site.

Case 59: Inhibition Of Enzymes Involved In Steroid Synthesis: Implications In Diabetes Treatment, Dr. Kathleen Cornely

Chemistry & Biochemistry Case Studies

Drugs used to increase insulin sensitivity may also inhibit enzymes involved in steroid synthesis. Prior to this investigation, it was uncertain whether the drugs inhibited the enzymes directly or whether the decrease in androgen synthesis observed during treatment was a secondary effect.

Gzmk(High) Cd8(+) T Effector Memory Cells Are Associated With Cd15(High) Neutrophil Abundance In Non-Metastatic Colorectal Tumors And Predict Poor Clinical Outcome, Silvia Tiberti, Carlotta Catozzi, Ottavio Croci, Mattia Ballerini, Danilo Cagnina, Chiara Soriani, Caterina Scirgolea, Zheng Gong, Jiatai He, Angeli D Macandog, Amir Nabinejad, Carina B Nava Lauson, Arianna Quinte', Giovanni Bertalot, Wanda L Petz, Simona P Ravenda, Valerio Licursi, Paola Paci, Marco Rasponi, Luca Rotta, Nicola Fazio, Guangwen Ren, Uberto Fumagalli-Romario, Martin H Schaefer, Stefano Campaner, Enrico Lugli, Luigi Nezi, Teresa Manzo

Faculty Research 2022

CD8+ T cells are a major prognostic determinant in solid tumors, including colorectal cancer (CRC). However, understanding how the interplay between different immune cells impacts on clinical outcome is still in its infancy. Here, we describe that the interaction of tumor infiltrating neutrophils expressing high levels of CD15 with CD8+ T effector memory cells (TEM) correlates with tumor progression. Mechanistically, stromal cell-derived factor-1 (CXCL12/ SDF-1) promotes the retention of neutrophils within tumors, increasing the crosstalk with CD8+ T cells. As a consequence of the contact-mediated inter- action with neutrophils, CD8+ T cells are skewed to produce high levels of GZMK, …

Caching Behavior In Burying Beetles, Stephen T. Trumbo

EEB Articles

Being the first to discover a resource can provide a competitive advantage (priority effect), even for an animal that is inferior in aggressive contests. Nicrophorus spp. (burying beetles) are known for caching a small vertebrate carcass as provision for their young, reducing volatile cues available to rivals by burying the carcass (vertical movement) and by altering the microbial community. A decomposing carcass, however, can leave cues (residues of decay) on soil and leaf litter that a burying beetle has less opportunity to neutralize. I investigated whether horizontal movement of the carcass by burying beetles, separating the carcass from soil at …

On The Scaling Properties Of Oscillatory Modes With Balanced Energy, Dobromir Dotov

Journal Articles

Animal bodies maintain themselves with the help of networks of physiological processes operating over a wide range of timescales. Many physiological signals are characterized by 1/f scaling where the amplitude is inversely proportional to frequency, presumably reflecting the multi-scale nature of the underlying network. Although there are many general theories of such scaling, it is less clear how they are grounded on the specific constraints faced by biological systems. To help understand the nature of this phenomenon, we propose to pay attention not only to the geometry of scaling processes but also to their energy. The first key assumption …

Molecular Diagnostic Survey Of Honey Bee, Apis Mellifera L., Pathogens And Parasites From Arkansas, Usa, Dylan Cleary, Allen L. Szalanski

Entomology Faculty Publications and Presentations

Managed honey bee populations have fluctuated over the past several decades in the U.S. While a single factor has not been identified for these losses, the interaction between multiple biotic and abiotic stressors have been suggested to be responsible. Of major concern are several invasive parasite and pathogen species as well as colony management. A single honey bee colony often suffers from multiple harmful agents, that may act synergistically and cause greater declines in bee health. We conducted a survey to detect known and lesser-known honey bee parasites and pathogens. While previous research has primarily focused on commercially managed colonies, …

Cardiac Myosin-Specific Autoimmune T Cells Contribute To Immune-Checkpoint-Inhibitor-Associated Myocarditis, Johns Hopkins University School Of Medicine, Johns Hopkins University Bloomberg School Of Public Health, Johns Hopkins University Whiting School Of Engineering, Ninaad Lasrado, Jay Reddy, Daniela Ciháková

School of Veterinary and Biomedical Sciences: Faculty Publications

Immune checkpoint inhibitors (ICIs) are an effective therapy for various cancers; however, they can induce immune-related adverse events (irAEs) as a side effect. Myocarditis is an uncommon, but fatal, irAE caused after ICI treatments. Currently, the mechanism of ICI-associated myocarditis is unclear. Here, we show the development of myocarditis in A/J mice induced by anti-PD-1 monoclonal antibody (mAb) administration alone without tumor cell inoculation, immunization, or viral infection. Mice with myocarditis have increased cardiac infiltration, elevated cardiac troponin levels, and arrhythmia. Anti-PD-1 mAb treatment also causes irAEs in other organs. Autoimmune T cells recognizing cardiac myosin are activated and increased …

Cardiac Myosin-Specific Autoimmune T Cells Contribute To Immune-Checkpoint-Inhibitor-Associated Myocarditis, Taejoon Won, Hannah M. Kalinoski, Megan K. Wood, David M. Hughes, Camille M. Jaime, Paul Delgado, Monica V. Talor, Ninaad Lasrado, Jay Reddy, Daniela Čiháková

Jay Reddy Publications

Immune checkpoint inhibitors (ICIs) are an effective therapy for various cancers; however, they can induce immune-related adverse events (irAEs) as a side effect. Myocarditis is an uncommon, but fatal, irAE caused after ICI treatments. Currently, the mechanism of ICI-associated myocarditis is unclear. Here, we show the development of myocarditis in A/J mice induced by anti-PD-1 monoclonal antibody (mAb) administration alone without tumor cell inoculation, immunization, or viral infection. Mice with myocarditis have increased cardiac infiltration, elevated cardiac troponin levels, and arrhythmia. Anti-PD-1 mAb treatment also causes irAEs in other organs. Autoimmune T cells recognizing cardiac myosin are activated and increased …

Dietary Supplementation With Black Raspberries Altered The Gut Microbiome Composition In A Mouse Model Of Colitis-Associated Colorectal Cancer, Although With Differing Effects For A Healthy Versus A Western Basal Diet, Abby D. Benninghoff

Browse all Datasets

Black raspberries (BRB) are rich in anthocyanins with purported anti-inflammatory properties. However, it is not known whether dietary supplementation would ameliorate Western-diet enhanced gut inflammation and colon tumorigenesis. We employed a mouse model of colitis-associated colorectal cancer (CAC) to determine the effects of dietary supplementation with 5 to 10% (w/w) whole, freeze-dried BRB in male C57BL/6J mice fed either a standard healthy diet (AIN93G) or the total Western diet (TWD). In a pilot study, BRB suppressed colitis and colon tumorigenesis while also shifting the composition of the fecal microbiome in favor of taxa with purported health benefits, including Bifidobacteria pseudolongum. …

Atomistic Measurement And Modeling Of Intrinsic Fracture Toughness Of Two-Dimensional Materials, Jianguo Wen, Horacio D Espinosa

Faculty, Staff and Student Publications

Quantifying the intrinsic mechanical properties of two-dimensional (2D) materials is essential to predict the long-term reliability of materials and systems in emerging applications ranging from energy to health to next-generation sensors and electronics. Currently, measurements of fracture toughness and identification of associated atomistic mechanisms remain challenging. Herein, we report an integrated experimental-computational framework in which in-situ high-resolution transmission electron microscopy (HRTEM) measurements of the intrinsic fracture energy of monolayer MoS

Developing Tasty And Nutritious Sustainable Foods Using Note By Note Cooking And 3d Food Printing, Roisin Burke, Pauline Danaher, Maria Peña Niebuhr

Conference papers

Aim:

Note by Note (NbN) cooking and 3D food printing individually and in combination allow for the creation of customized nutritious foods. NbN cooking involves making foods from pure compounds or mixtures of compounds and allows for reduction of food spoilage and increase of the global output of agriculture.

Method:

NbN recipes were developed using pure compounds and mixtures of pure compounds, and printed with a Procusini® 3D food printer. The food item was selected. In this study, “Pasta” was selected for the soya and hemp samples and “Chocolate” for the pea protein sample. The recipes were prepared and the …

Smokejumper Obituary: Smith, Edward Woodson (Mccall 1968), National Smokejumper Association

Smokejumper Obituaries

No abstract provided.

Prevalence Of Sleep-Related Problems And Risks In A Community-Dwelling Older Adult Population: A Cross-Sectional Survey-Based Study, Nancy P Gordon, Jimmy H Yao, Leslea A Brickner, Joan C Lo

Faculty, Staff and Student Publications

BACKGROUND: Despite evidence of adverse health consequences of inadequate restorative sleep for older adults, assessment of sleep quantity, quality, and use of sleep aids is not routinely done. We aimed to characterize sleep problems, sleep risks, and advice received about sleep in a community-dwelling older adult population, overall and in subgroups with health conditions and functional difficulties.

METHODS: This cross-sectional study used weighted self-report data for 5074 Kaiser Permanente Northern California members aged 65-79y who responded to a 2017 or 2020 Member Health Survey. We estimated usual amount of sleep (< 6, 6 to < 7, ≥7 hours) and prevalence of sleep problems (frequent insomnia, frequent daytime fatigue, poor quality sleep, and potential sleep apnea (OSA) symptoms (frequent very loud snoring, apnea episodes)) for older adults overall, by self-rated health, and in subgroups reporting hypertension, diabetes, heart disease, frequent problems with balance/walking, and frequent memory problems. We also estimated percentages who regularly used sleep aids and had discussed sleep adequacy with a healthcare professional in the past year.

RESULTS: Approximately 30% of older adults usually got less …

Omics Analyses Of A Somatic Trp53r245w/+ Breast Cancer Model Identify Cooperating Driver Events Activating Pi3k/Akt/Mtor Signaling, Xiaojie Yu, Yun Zhang, Shunbin Xiong, Joy M Mcdaniel, Chang Sun, Jovanka Gencel-Augusto, Rhiannon L Morrissey, Xiayu Rao, Jing Wang, Guillermina Lozano

Faculty, Staff and Student Publications

Alterations of the tumor suppressor

A Randomized Pilot Study Of Oncology Massage To Treat Chemotherapy-Induced Peripheral Neuropathy, Gabriel Lopez, Cathy Eng, Michael Overman, David Ramirez, Wenli Liu, Pamela Sumler, Yisheng Li, Minxing Chen, Eduardo Bruera, Lorenzo Cohen

Faculty, Staff and Student Publications

This pilot randomized controlled trial investigated massage therapy for symptomatic relief of chemotherapy-induced peripheral neuropathy (CIPN) to determine the ideal weekly frequency and number of weeks of providing massage. We evaluated the feasibility and initial efficacy of a Swedish massage protocol to treat lower extremity (LE) CIPN. Inclusion criteria: LE neuropathy attributed to oxaliplatin, paclitaxel, or docetaxel, with no other attributable causes; ≥ 6 months since last chemotherapy; self-reported neuropathy score ≥ 3, 0-10 scale; age ≥ 18. Participant randomization (2:2:1:1) to one of four groups: LE (2) or head/neck/shoulder (control; 1) massage 3 times (3X) a week for 4 …

Body Mass Index And Survival After Cancer Diagnosis: A Pan-Cancer Cohort Study Of 114 430 Patients With Cancer, Huakang Tu, Jennifer L Mcquade, Michael A Davies, Maosheng Huang, Kunlin Xie, Wong-Ho Chow, Xifeng Wu

Faculty, Staff and Student Publications

The recommendation encouraging patients with cancer to keep a normal body mass index (BMI) is largely extrapolated from data on risk of developing cancer. We tested the prospective association between peri-diagnostic (within 1 year post-diagnosis) BMI and all-cause mortality in patients with incident cancers. During 7.2 years of follow-up, 42% (48,340) of the 114 430 patients with cancer died. Spline analysis revealed that compared with a BMI of 22.5, a BMI lower than 22.5 was associated with increased risk of all-cause mortality across 24 cancer types. A BMI higher than 22.5 was associated with reduced all-cause mortality, while a non-linear …

Turning Algal Biomass Waste Into A Sustainable Substrate For Oyster Settlement, Ariana Liezl M. Lipat

Honors College Theses

When an aquatic ecosystem becomes oversaturated with nutrients, algae in the water utilize the excess nitrogen and phosphorus present and grow uncontrollably. This creates algal blooms on the surface of the water that deplete oxygen levels in the water and kill numerous organisms in the process. One method used to solve this issue is through Algal Turf Scrubber (ATS) technology: a natural wastewater treatment process in which water polluted with excess nitrogen and phosphorus is pumped across a floway to be absorbed by a culture of algae before it flows out of the system. The algal biomass is harvested periodically …

Cougars In The Eastern United States, Justina Raleva, Kenneth Rieche

Scholars Week

Since the 1900s, cougars have been extirpated from nearly everywhere except the western United States parks and wilderness areas. In recent years, cougars have been starting to spread their range outside of the Rocky Mountains, towards eastern states like Illinois, Missouri, and Louisiana. The purpose of this project is to conduct outreach and education through a brochure that would educate locals in Kentucky and Tennessee regarding cougar safety and conservation importance.

Retrieve, Race, Release, Karamello Young, Paige Mccord, Madison Morrison, Emily Fitzgerald

Scholars Week

Title: Retrieve, Race, Release

by: Paige McCord, Karamello Young, Madison Morrison, Emily Fitzgerald

Abstract: This poster represents a service-learning project that was done for our conservation biology class. Our main goal is to educate the public about the negative impacts of turtle derbies. We did this by using educational materials to raise awareness about turtle races and the impact of painting them with toxic substances before releasing them into a habitat that is not their natural one. We did not seek out to prohibit or stop the races as that would cause people to shut down and not listen as …

Foliar Application Of Acetic Acid And Effectiveness Against Drought At Different Time Points In Soybean Development, Miranda Rudolph

Scholars Week

Abstract

Drought is arguably the most serious environmental factor affecting crop production today. A plants response to drought stress is extremely complex, affecting numerous metabolic pathways that are all interconnected in their responses. Due to this complex nature, scientists do not fully understand the implications of different treatments and how they affect these processes. Acetic acid has been shown to improve plant growth and resistance to drought stress, but exactly how it accomplishes this is also unknown. Soybeans (Glycine max) are one of the most important crops worldwide and can suffer significant yield loss due to drought stress. As climate …

Optical Classification Of An Urbanized Estuary Using Hyperspectral Remote Sensing Reflectance, Kyle J. Turner, Maria Tzortziou, Brice K. Grunert, Joaquim Goes, Jonathan Sherman

Biological, Geological, and Environmental Faculty Publications

Optical water classification based on remote sensing reflectance (Rrs(.)) data can provide insight into water components driving optical variability and inform the development and application of bio-optical algorithms in complex aquatic systems. In this study, we use an in situ dataset consisting of hyperspectral Rrs(.) and other biogeochemical and optical parameters collected over nearly five years across a heavily urbanized estuary, the Long Island Sound (LIS), east of New York City, USA, to optically classify LIS waters based on Rrs(.) spectral shape. We investigate the similarities and differences of discrete groupings (k-means clustering) and continuous spectral indexing using the Apparent …

Differential Expression And Activities Of Cytochrome P450 3a In The Rat Brain Microsomes And Mitochondria, Nouf Alshammari, Devaraj Venkatapura Chandrashekar, Mamunur Rashid, Reza Mehvar

Pharmacy Faculty Articles and Research

Midazolam (MDZ), a benzodiazepine derivative, is metabolized to 1′- and 4-hydroxylated metabolites (1′-OH-MDZ and 4-OH-MDZ, respectively) by cytochrome P450 3A (CYP3A). The purpose of this study was to investigate the CYP3A-mediated hydroxylation of MDZ in the rat brain mitochondria (MT). Brain microsomes (MC) and MT fractions were prepared from rats (n = 8) using differential and density gradient centrifugations, and the purity of the fractions was evaluated using VDAC1 and calreticulin as markers of MT and MC, respectively. The formation rates of 1′-OH-MDZ and 4-OH-MDZ in the rat brain MC and MT samples were determined using an LC–MS/MS method …

Undetectable Very-Low Frequency Sound Increases Dancing At A Live Concert, Daniel J. Cameron, Dobromir Dotov, Erica Flaten, Dan Bosnyak, Michael J. Hove, Laurel Trainor

Journal Articles

Does low frequency sound (bass) make people dance more? Music that makes people want to move tends to have more low frequency sound, and bass instruments typically provide the musical pulse that people dance to1. Low pitches confer advantages in perception and movement timing, and elicit stronger neural responses for timing compared to high pitches2, suggesting superior sensorimotor communication. Low frequency sound is processed via vibrotactile3 and vestibular4 (in addition to auditory) pathways, and stimulation of these non-auditory modalities in the context of music can increase ratings of groove (the pleasurable urge to move to music) …

Making And Managing Wild Bee Hotels, Ann Mull, Lori R. Spears, Sheriden M. Hansen, Andree' Walker Bravo, Ricardo Ramirez, Jaydee Gunnell

All Current Publications

Bee hotels (also called "bee boxes" and "bee blocks") are popular additions to Utah backyards and commercial agriculture alike, adding nesting habitat to aid local pollination efforts and address native pollinator declines. This fact sheet provides information about the construction, placement, and maintenance of bee hotels. It also addresses monitoring of bee enemies.

The “Big Six”: Hidden Emerging Foodborne Bacterial Pathogens, Mona G. Alharbi, Rashad R. Al-Hindi, Ahmed Esmael, Ibrahim A. Alotibi, Sheren A. Azhari, Mazen S. Alseghayer, Addisu D. Teklemariam

Nebraska Center for Virology: Faculty Publications

Non-O157 Shiga toxin-producing Escherichia coli (STEC) are emerging serogroups that often result in diseases ranging from diarrhea to severe hemorrhagic colitis in humans. The most common non-O157 STEC are O26, O45, O103, O111, O121, and O145. These serogroups are known by the name “big six” because they cause severe illness and death in humans and the United States Department of Agriculture declared these serogroups as food contaminants. The lack of fast and efficient diagnostic methods exacerbates the public impact of the disease caused by these serogroups. Numerous outbreaks have been reported globally and most of these outbreaks were caused by …