Life Sciences Commons^™

The Effects Of Cross-Training On A Barrel Horse, Autumn Gallagher

Honors Theses

No abstract provided.

Smokejumper Obituary: Demmons, Jack Lawrence (Missoula 1950), National Smokejumper Association

Smokejumper Obituaries

No abstract provided.

Research Status And Prospect Of Key Technologies For Automatic Production Of Fresh And Wet Rice Flour, Mou Xiangwei, Song Yongfu, Chen Lintao

Food and Machinery

Firstly, this paper expounds the research status at home and abroad of three key technologies in the production process of fresh and wet rice flour: efficient powder dispersion, accurate weighing and automatic packaging, and focuses on the key technical problems existing in the research and development of technology and mechanical equipment; Secondly, on the basis of summarizing the development level of existing technology and equipment, this paper further analyzes the main reasons for these problems. Finally, the development direction of three key technologies in the automatic production of fresh and wet rice flour is prospected from the aspects of production …

Spatially Aware Dimension Reduction For Spatial Transcriptomics, Lulu Shang, Xiang Zhou

Faculty, Staff and Student Publications

Spatial transcriptomics are a collection of genomic technologies that have enabled transcriptomic profiling on tissues with spatial localization information. Analyzing spatial transcriptomic data is computationally challenging, as the data collected from various spatial transcriptomic technologies are often noisy and display substantial spatial correlation across tissue locations. Here, we develop a spatially-aware dimension reduction method, SpatialPCA, that can extract a low dimensional representation of the spatial transcriptomics data with biological signal and preserved spatial correlation structure, thus unlocking many existing computational tools previously developed in single-cell RNAseq studies for tailored analysis of spatial transcriptomics. We illustrate the benefits of SpatialPCA for …

Myc Regulates A Pan-Cancer Network Of Co-Expressed Oncogenic Splicing Factors., Laura M Urbanski, Mattia Brugiolo, Sunghee Park, Brittany Lynn Angarola, Nathan Leclair, Marina Yurieva, Phil Palmer, Sangram Keshari Sahu, Olga Anczuków

Faculty Research 2022

MYC is dysregulated in >50% of cancers, but direct targeting of MYC has been clinically unsuccessful. Targeting downstream MYC effector pathways represents an attractive alternative. MYC regulates alternative mRNA splicing, but the mechanistic links between MYC and the splicing machinery in cancer remain underexplored. Here, we identify a network of co-expressed splicing factors (SF-modules) in MYC-active breast tumors. Of these, one is a pan-cancer SF-module correlating with MYC activity across 33 tumor types. In mammary cell models, MYC activation leads to co-upregulation of pan-cancer module SFs and to changes in >4,000 splicing events. In breast cancer organoids, co-overexpression of the …

Planarian Fragments Behave As Whole Animals, D. Le, Ziad Sabry , '21, A. Chandra, W. B. Kristan Iii, Eva-Maria S. Collins, W. B. Kristan Jr.

Biology Faculty Works

Behavioral responses of freshwater planarians have been studied for over a century. In recent decades, behavior has been used as a readout to study planarian development and regeneration, wound healing, molecular evolution, neurotoxicology, and learning and memory. The planarian nervous system is among the simplest of the bilaterally symmetric animals, with an anterior brain attached to two ventral nerve cords interconnected by multiple commissures. We found that, in response to mechanical and near-UV stimulation, head stimulation produces turning, tail stimulation produces contraction, and trunk stimulation produces midbody elongation in the planarian Dugesia japonica. When cut into two or three pieces, …

Hydroponics And Vertical Farming Methods, John Rose

D.U.Quark

No abstract provided.

Anemone Cut Flower Production Budget, One High Tunnel, Northern Utah, 2022, Shannon Rauter, Melanie Stock, Ruby Ward

All Current Publications

This budget contains costs (preplant and site preparation, establishment and maintenance, and harvest and processing) and returns for the production and sale of anemone cut flowers that were grown in a high tunnel (14 feet by 40 feet). Production methods, yield, costs, and pricing were determined from Utah State University (USU) research trials, as well as feedback from Northern Utah producers. The costs and returns represent typical production in Northern Utah but should be adjusted where necessary for individual situations. Site selection, tunnel use, variety, harvest timing, pest management, and other practices will impact costs and returns to a cut-flower …

Lionfish (Pterois Volitans) Neurocranium, Vincenzo Ledonne, David William Kerstetter

All Scans: Kerstetter Fisheries and Avian Ecology 3D Scan Series

Neurocranium from 7.3025 cm total length (TL) [Lionfish (Pterois volitans)]

Data For Gridding, Joseph D. Birch, James A. Lutz, Soren Struckman, Jessica Miesel, Justine Karst

Browse all Datasets

Background: Large-diameter trees have an outsized influence on aboveground forest dynamics, composition, and structure. Although their influence on aboveground processes is well studied, their role in shaping belowground fungal communities is largely unknown. We sought to test if (H1) fungal community spatial structure matched aboveground forest structure, (H2) fungal functional guilds exhibited differential associations to aboveground tree, snag, and deadwood, and (H3) that large-diameter trees and snags have a larger influence on fungal community richness than smaller-diameter trees. We used MiSeq sequencing of fungal communities collected from soils in a spatially intensive survey in a portion of Cedar Breaks National …

The Development Of A Genomic Toolbox For Studying The Evolutionary Genetics Of Reptilian Lungs Using The Chicken Model, Logan Thomas Edvalson

Theses and Dissertations

There is a vast diversity in tetrapod lung branching morphology. Phylogenetically, much of the pulmonary diversity among vertebrates appears to arise from the way epithelial tubes branch or form saccular (cyst) structures. Fgf10 activity has been shown to play a critical role in regulating branch versus cyst morphology. We hypothesize that the species-specific differences in lung morphology may be primarily due to species-specific differences in Fgf10 expression. To test this hypothesis, we have performed bioinformatic analyses on the Fgf10 locus and have identified a conserved 11 kb noncoding region that potentially contains the Fgf10 lung enhancer. We are taking a …

Smokejumper Obituary: Sterling, Murray J. “Joe” (Missoula 1973), National Smokejumper Association

Smokejumper Obituaries

No abstract provided.

Triple Blockade Of Ido-1, Pd-L1 And Mek As A Potential Therapeutic Strategy In Nsclc, Carminia Maria Della Corte, Vincenza Ciaramella, Kavya Ramkumar, Giovanni Vicidomini, Alfonso Fiorelli, Salvatore Cappabianca, Federica Zito Marino, Gaetano Di Guida, Qi Wang, Robert Cardnell, Carl Michael Gay, Davide Ciardiello, Erika Martinelli, Teresa Troiani, Giulia Martini, Stefania Napolitano, Jing Wang, Lauren Averett Byers, Fortunato Ciardiello, Floriana Morgillo

Faculty, Staff and Student Publications

BACKGROUND: Despite the recent progress in the treatment and outcome of Non Small Cell Lung Cancer (NSCLC), immunotherapy has still significant limitations reporting a significant proportion of patients not benefiting from therapy, even in patients with high PD-L1 expression. We have previously demonstrated that the combined inhibition of MEK and PD-L1 in NSCLC patients derived three dimensional cultures exerted significant synergistic effect in terms of immune-dependent cancer cell death. However, subsequent experiments analyzing the expression of Indoleamine 2,3-dioxygenase-1 (Ido-1) gene expression demonstrated that Ido-1 resulted unaffected by the MEK inhibition and even increased after the combined inhibition of MEK and …

Low Rates Of Structured Advance Care Planning Documentation In Electronic Health Records: Results Of A Single-Center Observational Study, Adela Wu, Robert J Huang, Gabriela Ruiz Colón, Chris Zembrzuski, Chirag B Patel

Faculty, Staff and Student Publications

BACKGROUND: Proper advance care planning (ACP) documentation both improves patient care and is increasingly seen as a marker of high quality by governmental payers. The transition of most medical documentation to electronic health records (EHR) allows for ACP documents to be rapidly disseminated across diverse ambulatory practice settings. At the same time, the complexity and heterogeneity of the EHR, as well as the multiple potential storage locations for documentation, may lead to confusion and inaccessibility. There has been movement to promote structured ACP (S-ACP) documentation within the EHR.

METHODS: We performed a retrospective cohort study at a single, large university …

Full Issue

Humboldt Journal of Social Relations

Full issue of volume 35 of HJSR

Ncam1 And Gdf15 Are Biomarkers Of Charcot-Marie-Tooth Disease In Patients And Mice, Matthew J. Jennings, Alexia Kagiava, Leen Vendredy, Emily L Spaulding, Marina Stavrou, Denisa Hathazi, Anika Grüneboom, Vicky De Winter, Burkhard Gess, Ulrike Schara, Oksana Pogoryelova, Hanns Lochmüller, Christoph H. Borchers, Andreas Roos, Robert W. Burgess, Vincent Timmerman, Kleopas A. Kleopa, Rita Horvath

Faculty Research 2022

Molecular markers scalable for clinical use are critical for the development of effective treatments and the design of clinical trials. Here, we identify proteins in sera of patients and mouse models with Charcot-Marie-Tooth disease (CMT) with characteristics that make them suitable as biomarkers in clinical practice and therapeutic trials. We collected serum from mouse models of CMT1A (C61 het), CMT2D (GarsC201R, GarsP278KY), CMT1X (Gjb1-null), CMT2L (Hspb8K141N) and from CMT patients with genotypes including CMT1A (PMP22d), CMT2D (GARS), CMT2N (AARS) and other rare genetic forms of CMT. The severity of neuropathy in the patients was assessed by the CMT Neuropathy Examination …

Discovering New Potential Inhibitors To Sars-Cov-2 Rna Dependent Rna Polymerase (Rdrp) Using High Throughput Virtual Screening And Molecular Dynamics Simulations., Dylan Brunt, Phillip M Lakernick, Chun Wu

College of Science & Mathematics Departmental Research

RNA dependent RNA polymerase (RdRp), is an essential in the RNA replication within the life cycle of the severely acute respiratory coronavirus-2 (SARS-CoV-2), causing the deadly respiratory induced sickness COVID-19. Remdesivir is a prodrug that has seen some success in inhibiting this enzyme, however there is still the pressing need for effective alternatives. In this study, we present the discovery of four non-nucleoside small molecules that bind favorably to SARS-CoV-2 RdRp over the active form of the popular drug remdesivir (RTP) and adenosine triphosphate (ATP) by utilizing high-throughput virtual screening (HTVS) against the vast ZINC compound database coupled with extensive …

Mesoptroph, A Database Of Trophic Parameters To Study Interactions In Mesopelagic Food Webs, Mónica A. Silva, Catarina T. Fonseca, M. Pilar Olivar, Ainhoa Bernal, Jérôme Spitz, Tiphaine Chouvelon, Sigrún Jonasdottir, Ana Colaço, Vanda Carmo, Tracey Sutton, Gui Menezes, Tone Falkenhaug, Odd Aksel Bergstad, Sergi Pérez-Jorge

Marine & Environmental Sciences Faculty Articles

Mesopelagic organisms play a crucial role in marine food webs, channelling energy across the predator-prey network and connecting depth strata through their diel vertical migrations. The information available to assess mesopelagic feeding interactions and energy transfer has increased substantially in recent years, owing to the growing interest and research activity in the mesopelagic realm. However, such data have not been systematically collated and are difficult to access, hampering estimation of the contribution of mesopelagic organisms to marine ecosystems. Here we present MesopTroph, a georeferenced database of diet, trophic markers, and energy content of mesopelagic and other marine taxa compiled from …

Epidemiological Aspects Of Equid Herpesvirus-Associated Myeloencephalopathy (Ehm) Outbreaks, Eva Klouth, Yury Zablotski, Jessica L. Petersen, Marco De Bruijin, Gittan Gröndahl, Susanne Müller, Lutz S. Goehring

Department of Animal Science: Faculty Publications

: Equid Herpesvirus Myeloencephalopathy (EHM) is a multifactorial disease following an EHV-1 infection in Equidae. We investigated a total of 589 horses on 13 premises in Europe in search of risk factors for the development of EHM. We found that fever (p < 0.001), increasing age (p = 0.032), and female sex (p = 0.042) were risk factors for EHM in a logistic mixed model. Some breeds had a decreased risk to develop EHM compared to others (Shetland and Welsh ponies; p = 0.017; p = 0.031), and fewer EHV-1-vaccinated horses were affected by EHM compared to unvaccinated horses (p = …

Species Substitution And Mislabeling Of Ceviche, Poke, And Sushi Dishes Sold In Orange County, California, Courtney J. Kitch, Amanda M. Tabb, Grace E. Marquis, Rosalee S. Hellberg

Food Science Faculty Articles and Research

Raw, ready-to-eat (RTE) seafood products have become increasingly popular globally, but they are vulnerable to species substitution and mislabeling. DNA barcoding allows for fish species identification by extracting, amplifying, and sequencing a standardized gene target. A wide variety of fish products have been studied with DNA barcoding, but little investigation of ceviche and poke has occurred in the United States. Sushi is known to be a target of mislabeling but has not been extensively studied in Orange County, CA. The objective of this study was to investigate species substitution and mislabeling of sushi, poke, and ceviche dishes sold at restaurants …

Collective Dynamics Support Group Drumming, Reduce Variability, And Stabilize Tempo Drift, Dobromir Dotov, Lana Delasanta, Daniel J. Cameron, Edward W. Large, Laurel Trainor

Journal Articles

Humans are social animals who engage in a variety of collective activities requiring coordinated action. Among these, music is a defining and ancient aspect of human sociality. Human social interaction has largely been addressed in dyadic paradigms, and it is yet to be determined whether the ensuing conclusions generalize to larger groups. Studied more extensively in non-human animal behavior, the presence of multiple agents engaged in the same task space creates different constraints and possibilities than in simpler dyadic interactions. We addressed whether collective dynamics play a role in human circle drumming. The task was to synchronize in a group …

The Backyard Garden - Bean Pests, Nick Volesky, Bridger Carey, Marion Murray

All Current Publications

As part of a series, The Backyard Garden, this fact sheet examines bean pests. Insects and other pests include thrips, spider mites, cutworms and armyworms, Mexican bean beetle, and seedcorn maggot. Diseases include bean common mosaic virus, damping-off, beet curly top virus, common bacterial blight, and halo blight. The fact sheet includes general information about these issues, signs and symptoms on plants, and management.

The Backyard Garden - Pea Pests, Bridger Carey, Nick Volesky, Marion Murray

All Current Publications

As part of a series, The Backyard Garden, this fact sheet reviews pea pests. It includes general information, symptoms, and management for the following pea pest issues: thrips, spider mites, pea weevil, aphids, pea leaf weevil, damping-off, powdery mildew, fusarium wilt, fusarium root rot, and bacterial blight.

Hematophagy And Tick-Borne Rickettsial Pathogen Shape The Microbial Community Structure And Predicted Functions Within The Tick Vector, Amblyomma Maculatum., Abdulsalam Adegoke, Deepak Kumar, Khemraj Budachetri, Shahid Karim

Faculty Publications

Background: Ticks are the primary vectors of emerging and resurging pathogens of public health significance worldwide. Analyzing tick bacterial composition, diversity, and functionality across developmental stages and tissues is crucial for designing new strategies to control ticks and prevent tick-borne diseases.

Materials and methods: Here, we explored the microbial communities across the developmental timeline and in different tissues of the Gulf-Coast ticks (Amblyomma maculatum). Using a high-throughput sequencing approach, the influence of blood meal and Rickettsia parkeri, a spotted fever group rickettsiae infection in driving changes in microbiome composition, diversity, and functionality was determined.

Results: This study …

Quantifying Environmental Sensitivity Of Marine Resources To Oil Well Blowouts In The Gulf Of Mexico, Emily Chancellor

USF Tampa Graduate Theses and Dissertations

This dissertation focused on oil spill risk assessment techniques historically utilized for coastal resources (e.g., environmental sensitivity indices (ESIs), vulnerability assessments, species-specific vulnerability frameworks) and their application and expansion to offshore resources found in the Gulf of Mexico (GoM). Additional included techniques (e.g., multi-sector trade-off analysis, marine spatial planning (MSP) software) provide support in decision making processes regarding the potential siting of oil production sites and/or the withdrawal of areas from oil and natural gas production. Chapter 1 included an overview and justification for this study. Chapter 2 demonstrated an initial methodology for the creation of offshore ESIs and how …

From Model Organisms To Humans, The Opportunity For More Rigor In Methodologic And Statistical Analysis, Design, And Interpretation Of Aging And Senescence Research, Daniella E Chusyd, Steven N Austad, Andrew W Brown, Xiwei Chen, Stephanie L Dickinson, Keisuke Ejima, David Fluharty, Lilian Golzarri-Arroyo, Richard Holden, Yasaman Jamshidi-Naeini, Doug Landsittel, Stella Lartey, Edward Mannix, Colby J Vorland, David B Allison

Children’s Nutrition Research Center Staff Publications

This review identifies frequent design and analysis errors in aging and senescence research and discusses best practices in study design, statistical methods, analyses, and interpretation. Recommendations are offered for how to avoid these problems. The following issues are addressed: (a) errors in randomization, (b) errors related to testing within-group instead of between-group differences, (c) failing to account for clustering, (d) failing to consider interference effects, (e) standardizing metrics of effect size, (f) maximum life-span testing, (g) testing for effects beyond the mean, (h) tests for power and sample size, (i) compression of morbidity versus survival curve squaring, and (j) other …

A Field Synopsis, Systematic Review, And Meta-Analyses Of Cophylogenetic Studies: What Is Affecting Congruence Between Phylogenies?, Valeria Trivellone, Bernd Panassiti

MANTER: Journal of Parasite Biodiversity

We conducted a field synopsis and systematic meta-analysis of studies that carried out cophylogenetic analyses using algorithms and available software. We evaluated the influence of three factors—namely, cophylogenetic method, association, and ecosystem type—on the outcome of the analyses, that is, the degree of congruence between phylogenies of interacting species.

The published papers were identified using 4 different databases and 13 keywords; we included all studies for which statistical approaches to compare phylogenies (cophylogenetic analyses) of interacting lineages were used. After the initial screening, 296 studies were selected to extract response variable (outcome of the cophylogenetic analyses, i.e., congruent, incongruent, or …

Bob: Bayesian Optimal Design For Biosimilar Trials With Co-Primary Endpoints, Xiaohan Chi, Zhangsheng Yu, Ruitao Lin

Faculty, Staff and Student Publications

For regulatory approval of a biosimilar product, extensive evaluations should be performed by rigorous clinical trials to establish the similarity between the reference product and the proposed biosimilar in terms of both efficacy and safety. Existing designs for biosimilar trials often use a single primary efficacy endpoint in trial monitoring, and then separately evaluate the safety of the biosimilar product in a secondary analysis at the trial completion. However, ignoring the safety endpoint and the correlation between safety and efficacy in trial monitoring may lead to a high false positive rate, or it may delay the termination of the trial …

Phase Ii Study Of Venetoclax Added To Cladribine Plus Low-Dose Cytarabine Alternating With 5-Azacitidine In Older Patients With Newly Diagnosed Acute Myeloid Leukemia, Tapan M Kadia, Patrick K Reville, Xuemei Wang, Caitlin R Rausch, Gautam Borthakur, Naval G Daver, Koji Sasaki, Ghayas C Issa, Maro Ohanian, Guillermo Montalban-Bravo, Nicholas J Short, Nitin Jain, Alessandra Ferrajoli, Kapil N Bhalla, Elias Jabbour, Koichi Takahashi, Rashmi Malla, Kelly Quagliato, Rashmi Kanagal-Shamanna, Uday R Popat, Michael Andreeff, Guillermo Garcia-Manero, Marina Y Konopleva, Farhad Ravandi, Hagop M Kantarjian

Faculty, Staff and Student Publications

PURPOSE: The combination of venetoclax and 5-azacitidine (5-AZA) for older or unfit patients with acute myeloid leukemia (AML) improves remission rates and survival compared with 5-AZA alone. We hypothesized that the addition of venetoclax to cladribine (CLAD)/low-dose araC (low-dose cytarabine [LDAC]) alternating with 5-AZA backbone may further improve outcomes for older patients with newly diagnosed AML.

METHODS: This is a phase II study investigating the combination of venetoclax and CLAD/LDAC alternating with venetoclax and 5-AZA in older (≥ 60 years) or unfit patients with newly diagnosed AML. The primary objective was composite complete response (CR) rate (CR plus CR with …

Orthochirus Katerinae Sp. N. (Scorpiones: Buthidae) From Saudi Arabia, František Kovařík, Pavel Just

Euscorpius

We describe a new species Orthochirus katerinae sp. n. from Saudi Arabia, previously cited as Orthochirus innesi Simon 1910, ssp. ?, the name many years used as an ‘umbrella’ for various Orthochirus from North Africa and Arabia. The new species is described based on males characterized mainly by: total length 26–30 mm; pectinal teeth number 16–20; movable finger of pedipalps with 7–8 rows of denticles, 8–9 ID and 7 OD; tarsomere I of legs I–III with 3–5 long setae; ratio length/width of metasoma V 1.13–1.16; pedipalp femur length/width ratio 3.30–3.32.