Life Sciences Commons^™

Value Of Qrs Fragmentation As Novel Electrocardiogram Predictor Of Reperfusion In Acute Myocardial Infarction Patient, Hoda M. Sobh, Nader E. Awad, Mohamed A. Omar

Mansoura Medical Journal

Background: The main target of treatment of STEMI is to restore coronary blood flow and maintain myocardial perfusion. Several tools including electrocardiographic and coronary angiographic parameters are used to assess myocardial reperfusion. Fragmented QRS is associated with increased adverse cardiovascular events, it was proved to bea marker of ventricular dysfunction and poor prognosis in STEMI. Aim of the work : To study the relation between QRS fragmentations and the degree of myocardial reperfusion in patients with STEMI treated with either fibrinolytic therapy or primary percutaneous coronary interventions (1ry PCI). Patients and methods: 100 subjects admitted with first attack of STEMI …

Long-Term Stability Of Electrical Stapedial Reflex And Electrodes Impedance In Children With Med-El Cochlear Implants, Maram Mohamed Rashad Ghoniem, Ayman El-Saeed Elsharabasy, Yousef Kamel Shabana, Elshahat Ibrahem Ismail

Mansoura Medical Journal

Background

The purpose of this study was to investigate changes in electrical evoked stapedial reflex thresholds (ESRTs) and electrodes impedance over time in children with MED-EL cochlear implants.

Methods

In this study, 60 kids were included, while 15 kids were excluded because their cases did not fit the requirements. Patients who received MED-EL cochlear implants were monitored postoperatively over 5 years to determine whether or not their ESRT and electrode impedance remained stable.

Results

At the initial fitting, electrodes 4, 5, 6, 8, and 9 showed significantly different impedances, while electrodes 1, 2, 3, 7, 10, 11, and 12 showed …

One Stage Procedure Versus Two Stages Procedure In Management Of Obstructed Non-Perforated Cancer Colon, Magdy Basheer, Mahmoud Neamatallah, Ashraf Abbas, Mohamed Shetiwy

Mansoura Medical Journal

Background: The surgical management of large bowel emergency patients remains controversial. However, there has been an increasing trend toward primary reconstructive surgery. Objective: To evaluate one-stage procedure versus two-stage procedure in cases presented with obstructed nonperforated cancer colon in terms of operative time, hospital stay, postoperative complications, peri-operative mortality, and quality of life. Patients and methods: A prospective randomized study was conducted at Emergency Mansoura University Hospitals. A total of 50 cases diagnosed with obstructed nonperforated cancer colon were randomly allocated into two groups; the first group included 25 cases who underwent the one-stage approach, and the second one included …

Outcome Of Covid-19 In Patients With Rheumatic Diseases Treated With Immunosuppressive Drugs, Ali Sobh, Noha Hazem Elnagdy, Mohamed Elegezy, Mohamed Mofreh, Mohamed Tohlob, Ahmad M. Eita, Ragheed Rizk, Ola Eliwa, Marwa H. Elnagdy, Ahmed Elsaeed Abdulgalil

Mansoura Medical Journal

Background: Rheumatologic disorders have been significantly impacted by the coronavirus disease 2019 (COVID-19) pandemic. The potential role of immunosuppressive drugs in the presentation, severity and even management of COVID-19 is still questionable. The aim of this work was to study the effect of immunosuppressive drugs on outcome of COVID-19 infection in patients with rheumatic diseases. 109 rheumatic patients (37 pediatrics and 72 adults) taking immunosuppressive treatment with confirmed COVID-19 infection were included in this study. Clinical, laboratory, radiological findings and outcome of these patients were retrospectively retrieved from hospital medical records. Results: The majority of adult cases were rheumatoid arthritis …

Unusual Late Presentation Of Kartagener Syndrome: A Case Report, Abdulhadi H. Al-Mazroea

Mansoura Medical Journal

Kartagener's syndrome (KS) is a rare inherited autosomal recessive condition. It comprises of the triad chronic sinusitis, bronchiectasis, and situs inversus. The symptoms are more prevalent in children in the early years of life. We describe a case of a 15-year-old child showing severe respiratory distress with a history of intermittent wet cough and rhinitis for the past six months. The patient was diagnosed with dextrocardia at birth and had no significant medical history since then. Based on his clinical presentation and imaging findings, he was diagnosed with KS that was confirmed by whole-exome sequencing. The patient was managed with …

Evaluation Of Congenital Coronary Arteries Anomalies On Cardiac Computed Tomography Angiography (Cta) For Congenital Heart Diseases, Zainab A. Ramadan

Mansoura Medical Journal

Background and purpose: Coronary arteries anomalies (CAA) are generally rare but more common to co-exist with congenital cardiac anomalies. These include several congenital conditions either origin, course, or termination. This study aims to emphasize that the accurate evaluation of CAA on cardiac computed tomography angiography (CTA) is a must prior to proper surgical intervention in congenital heart diseases (CHD) to prevent unnecessary procedures or vascular injury of these vital arteries. Methods: Cardiac CTA scans for patients with suspected cardiac anomalies or diseases were retrospectively reviewed by radiologist for the presence of CAA between February 2020 and March 2023. CAA were …

Don’T Miss What Is Hidden On Cardiac Ct Angiography: Extra-Cardiac Findings Count, Zainab Ahmad Ramadan, Aya Ahmed Elboghdady, Aya Mohammed Abdel Aziz, Farah Ahmed Shokeir

Mansoura Medical Journal

Background: Multi-detector computed tomography (MDCT)is the main imaging modality in cardiovascular diseases. Another important role of MDCT is assessment of extra-cardiac structures outside the pericardium. These extra-cardiac findings may be of great relevance. Methods: Cardiac MDCT scan results were retrospectively reviewed by radiologist for the presence of extra-cardiac findings between February 2020 and December 2022. They were categorized according to anatomical location into systems as pulmonary, pleural, mediastinal, bronchial, vascular, bony, abdominal and miscellaneous. Results: A total of 955 patients had a cardiac multidetector CT angiography scan during the study period. Extra-cardiac findings were reported in 320 (33.5%) of these …

Developing A Computer-Based Program For Language Rehabilitation Of Arabic-Speaking Aphasic Patients, Sara Elsherbeny, Ayman Amer, Hemmat Baz, Tamer Abou-Elsaad

Mansoura Medical Journal

Background: Aphasia is acquired selective impairment of language. Computerized aphasia therapy is useful in language therapy and offers chances for independent practice at home to maximize intensity and improve outcomes. The aim of this study was to develop a computer-based language rehabilitation program for Arabic-speaking Egyptian aphasic patients to be culturally, linguistically and socially suitable for them and to determine its effectiveness. Methods: We conducted a prospective interventional study on 20 aphasic patients in the age range 40-65 years who received rehabilitation for 3 months using a newly designed Arabic software program named “Takalam”. The program was pilot-studied on 10 …

Migraine Among Neurology Outpatient Attendants In Mansoura University: Sociodemographic And Migraine Comorbidities Analysis, Mohammad Youssif Ismail Ibrahim, Tamer Mohammad Belal, Hossam Mohammad Egila, Ahmed Gamal Azab

Mansoura Medical Journal

Background: Twelve percent of the population is thought to suffer from migraines. 1% to 2% of individuals worldwide suffer from chronic migraine (CM). Approximately 2.5% of cases who have episodic migraine (EM) develop CM. A number of risk factors are linked to the development of CM. Independent of medication; there is a sizable short-term variance in migraine frequency. Sleep difficulties, psychological illness, and cardiovascular disease are all linked to migraine. It is the second most incapacitating illness globally. Objectives: To evalaute the sociodemographic characteristics of migraineurs and their different co-morbidities. Patients and methods: A cross-sectional study with analytic component was …

Myocardial And Renal Protective Effects Of Dexmedetomidine Vs Magnesium Sulphate In Patients Undergoing Elective Open Abdominal Aortic Surgery, Mohamed Younes Yousef Abd Allah, Maha Younes Youssef Abd-Allah, Abdelrahman Mohammed Elnagar

Mansoura Medical Journal

Background: After abdominal aortic aneurysm surgery, the likelihood of postoperative myocardial infarction is seven percent, but likelihood of postoperative cardiac problems without signs of ischemic damage is thirty-six percent. Aim: goal of research had been to assess perioperative myocardial protective impact of dexmedetomidine and magnesium sulphate in high‑risk studied cases undergoing aortic vascular surgery. Methods: This randomized double blinded research had been being done in cardiothoracic & vascular surgery center, Mansoura university from May 2023 to October 2023 after approval from institutional review board of faculty of Medicine Mansoura University with obtaining a written informed consent from all studied cases. …

Ultrasound Guided Nerve Block In Cervicogenic Headache, Zeinab Adel Ghorab, Azza Elmongui, Ahmed Azab, Osama Elshafei

Mansoura Medical Journal

Background: Cervicogenic headache (CGH) has been considered as a common type of headache all over the world. There are a lot of therapeutic modalities for Cervicogenic headache either non-invasive or invasive strategies. Based on the original cause of pain, there are several approaches of local or regional anesthesia injections comprising nerve root injections, trigger point blocks, peripheral nerve blocks, or facet blocks Aim: To assess the efficacy of the ultrasound (US)-guided greater occipital nerve (GON ) block in Cervicogenic headache . Methods: The study was designed as a prospective interventional study that included 50 patients with Cervicogenic headache after fulfillment …

Prevalence Of Colorectal Polyps And Associated Risk Factors In Egyptian Population: A Single Center Study, Hossam El Refaey, Hazem Hakim, Ahmed Saed

Mansoura Medical Journal

Background: Intestinal polyps are noticeable mucosal outgrowths that extend into lumen of gastrointestinal tract. In adults, the most frequently detected polyps are adenomatous polyps which are thought to be precursors of large bowel cancer. Colonoscopy is the most widely accepted method for colon cancer screening. Early detection and removal of adenomas can significantly reduce risk of colorectal cancer hence; it is of great importance to evaluate the prevalence of colorectal polyps in Egyptian population by diagnostic colonoscopy and associated risk factors. Objective: detect the prevalence of colorectal polyps in Egyptian population and associated risk factors. Patients and Methods: A cross …

Value Of Optical Coherence Tomography And Optical Coherence Tomography Angiography In Relation To Disability Progression In Multiple Sclerosis Patients, Hossam Abd El-Nasser Kamal, Ahmed Effat Abbas Mohamed Saeid, Amgad Mahmoud El Nokrashy, Mohamed Galal El-Khateeb

Mansoura Medical Journal

Background: Optical coherence tomography (OCT) and OCT-angiography (OCT-A) permit quantification of retinal layer atrophy relevant to multiple sclerosis (MS) progression. Methods: We conducted this case-control study to assess of the changes in OCT and OCTA measures in relation to the duration of MS and the expanded disability status scale (EDSS). A total of 70 MS patients compared to 35 healthy controls were enrolled. Results: According to OCT findings, there was a significantly lower mean value of retinal nerve fiber layer thickness (RNFL) and ganglion cell complex (GCC) in the MS patients group compared to the control group with p1.5 exhibited …

The Effect Of Adding Magnesium Sulphate Versus Dexmedetomidine As An Adjuvant To Bupivacaine In Ultrasound Rectus Sheath Block On Postoperative Analgesia In Patients Undergoing Abdominal Aortic Surgery, Ghada Fouad Amer, Mohamed Younes Yousef Abd Allah

Mansoura Medical Journal

Background: With significant advancements in the area, post-operative pain management after abdominal procedures has garnered attention lately. Despite these developments, post-operative pain is still difficult to manage and is sometimes not sufficiently addressed, which causes worry, tension, and discontent in the patient. In addition to having negative medical impacts, inadequate pain management may also have negative psychological, economic, and societal repercussions. Aim and objectives: To assess the analgesic impacts of dexmedetomidine against magnesium sulphate when used as a bupivacaine adjuvant during ultrasound-guided bilateral rectus sheath block during abdominal aortic surgery. Patients and methods: Over the course of five months, 40 …

Serum Trefoil Factor 3 As A Diagnostic Marker Of Hepatocellular Carcinoma Related To Chronic Hepatitis C Cirrhosis, Mohammed El Hagrasy, Ashraf Omar, Hosam Abdel Twab, Ahmed Saed

Mansoura Medical Journal

Background: Liver cancer, specifically Hepatocellular Carcinoma (HCC), is a main cause of cancer-related deaths globally. Early detection of HCC is also a significant challenge. Our research aimed to examine serum trefoil factor 3 (TFF3) level compared to alpha-fetoprotein (AFP) in diagnosis and prognosis of HCC and other hepatitis C virus (HCV)-related liver diseases. Methods: This single-center prospective study was performed at a Specialized Medical Hospital, Faculty of Medicine, Mansoura University, over a duration of 6 months from May to October 2021. The study consisted of 35 cases with HCC on top of cirrhosis, 35 with HCV-induced cirrhosis, and 20 healthy …

Making Sense Of Big (Kinematic) Data: A Comprehensive Analysis Of Movement Parameters In A Diverse Population, Naomi Wilma Nunis

University of the Pacific Theses and Dissertations

OBJECTIVE

The purpose of this study was to determine how kinematic, big data can be evaluated using computational, comprehensive analysis of movement parameters in a diverse population.

METHODS

Retrospective data was collected, cleaned, and reviewed for further analysis of biomechanical movement in an active population using 3D collinear resistance loads. The active sample of the population involved in the study ranged from age 7 to 82 years old and respectively identified as active in 13 different sports. Moreover, a series of exercises were conducted by each participant across multiple sessions. Exercises were measured and recorded based on 6 distinct biometric …

Quantifying The Impacts Of Genetically Engineered Crops And Deep Soil C Cycling On The Sustainability Of Bioenergy Crop Production, Zoe Pagliaro

Graduate Theses, Dissertations, and Problem Reports (ETD)

Bioenergy can help mitigate climate change by providing a carbon-neutral fuel source. However, multiple challenges exist to achieving carbon neutrality including converting lignocellulosic materials to fuel and enhancing soil C sequestration during the growth of the feedstocks. To address these challenges, there have been recent efforts to genetically modify feedstocks to produce more energy dense oils that increase fuel conversion efficiency and to cultivate deep-rooted perennial feedstocks that can enhance soil C storage. However, the C consequences and efficacy of these solutions remain largely uncertain.

To examine the C consequences of enhancing oil content of bioenergy feedstocks, I examined the …

Ubiquitination Of The Protocadherin-Γa3 Variable Cytoplasmic Domain Modulates Cell-Cell Interaction, Albert Ptashnik, Nicole Lamassa, Aliya Mambetalieva, Emily Schnall, Mike Bucaro, Greg R. Phillips

Publications and Research

The family of ∼60 clustered protocadherins (Pcdhs) are cell adhesion molecules encoded by a genomic locus that regulates expression of distinct combinations of isoforms in individual neurons resulting in what is thought to be a neural surface “barcode” which mediates same-cell interactions of dendrites, as well as interactions with other cells in the environment. Pcdh mediated same-cell dendrite interactions were shown to result in avoidance while interactions between different cells through Pcdhs, such as between neurons and astrocytes, appear to be stable. The cell biological mechanism of the consequences of Pcdh based adhesion is not well understood although various signaling …

Evaluating The Relative Influence Of Soil Water Potential, Soil Moisture, And Vapor Pressure Deficit On Semi-Arid Vegetation Dynamics, Kayla R. Jamerson

Graduate Student Theses, Dissertations, & Professional Papers

Knowledge of vegetation’s response to soil water availability and atmospheric demand is critical to understanding the impact of climate change on semi-arid ecosystems. However, limited field-based research has been conducted to assess the relative importance of these drivers and previous research has simplified the assessment of soil water availability by relying on soil volumetric water content (VWC) as a primary control on plant growth, which, as opposed to soil water potential (Ψsoil), does not account for the effects of soil texture on plant available water. To address these gaps, we compared remotely sensed indicators of vegetation response to field based …

Relationship Between Reproductive And Bone Biomarkers And Osteoarthritis In Zoo Asian (Elephas Maximus) And African (Loxodonta Africana) Elephants, Daniella E Chusyd, Janine L Brown, Lilian Golzarri-Arroyo, Stephanie L Dickinson, Virginia B Kraus, Jessica Siegal-Willott, Timothy M Griffin, Janet L Huebner, Katie L Edwards, David B Allison, Steven N Austad

Children’s Nutrition Research Center Staff Publications

Osteoarthritis (OA) is common in zoo Asian (Elephas maximus) and African (Loxodonta africana) elephants. This study investigated the relationship between confirmed or suspected OA with ovarian cyclicity, gonadotropins, progestagens, luteinizing hormone (LH), follicular stimulating hormone (FSH), and collagen type I (CTX-I) in zoo elephants. In Asian elephants, odds of having confirmed or suspected OA decreased with cycling (OR = 0.22, P = 0.016; OR = 0.29, P = 0.020, respectively), however, not when adjusted for age (odds ratio [OR] = 0.31, P = 0.112; OR = 0.58, P = 0.369, respectively). In African elephants, none of …

Conditioning On Parental Mating Types Can Reduce Necessary Assumptions For Mendelian Randomization, Keisuke Ejima, Nianjun Liu, Luis Miguel Mestre, Gustavo De Los Campos, David B Allison

Children’s Nutrition Research Center Staff Publications

Mendelian randomization (MR) has become a common tool used in epidemiological studies. However, when confounding variables are correlated with the instrumental variable (in this case, a genetic/variant/marker), the estimation can remain biased even with MR. We propose conditioning on parental mating types (a function of parental genotypes) in MR to eliminate the need for one set of assumptions, thereby plausibly reducing such bias. We illustrate a situation in which the instrumental variable and confounding variables are correlated using two unlinked diallelic genetic loci: one, an instrumental variable and the other, a confounding variable. Assortative mating or population admixture can create …

Table Of Contents

Human–Wildlife Interactions

This is the table of contents.

Tradeoffs May Counteract Effects Of Telecommunication Towers On Osprey Nesting, Gage R. Barnes, Kate G. Slankard, John B. Hewlett, Andrea K. Darracq

Human–Wildlife Interactions

The number of telecommunication towers (TCTs) throughout the United States has and continues to increase exponentially. Increased TCT placement has been implicated in local population increases in platform nesting birds such as ospreys (Pandion haliaetus). However, osprey use of artificial structures can cause conflicts with humans because of economic costs and risks to human safety. Managers require better information regarding the effect of artificial nesting surfaces, such as TCTS, on osprey reproduction to make informed decisions regarding species conservation and to mitigate potential conflicts. The objective of our study was to evaluate the influence of TCTs on osprey …

Do Trap-Neuter-Return (Tnr) Practices Contribute To Human–Coyote Conflicts In Southern California?, Danielle M. Bucklin, Jennifer M. Shedden, Niamh M. Quinn, Robert Cummings, Paul Stapp

Human–Wildlife Interactions

One possible contributor to the unusually high number of conflicts between coyotes (Canis latrans) and people in urban southern California, USA, may be the abundance of free-roaming domestic cats (Felis catus; cats) subsidized by feeding and augmented by trap-neuter-return (TNR) programs. To determine if coyotes regularly prey on and consume cats, we combined visual and molecular-genetic approaches to identify prey items in stomachs of 311 coyotes from Los Angeles County and Orange County, provided to the South Coast Research and Extension Center, in Irvine, California, between June 2015 and December 2018. We detected cat remains in …

Habituated, Tolerant, Or Salt-Conditioned Mountain Goats And Human Safety, Richard B. Harris, Kurt Aluzas, Laura Balyx, Jami Belt, Joel Berger, Mark Biel, Tonya Chilton-Radandt, Steeve D. Côté, Julie Cunningham, Adam Ford, Patti Happe, Chad P. Lehman, Kim Poole, Clifford G. Rice, Kirk Safford, Wesley Sarmento, Laura Wolf

Human–Wildlife Interactions

Interactions between humans and wildlife include a number of consumptive and non-consumptive forms. In some cases, the increased demand for wildlife viewing can precipitate new human–wildlife conflicts. Mountain goats (Oreamnos americanus; goats) are native to a number of North American mountain ranges from southeastern Alaska to southwestern Montana, USA. Goat habitat typically consists of steep terrain and cold weather habitats, which has left them particularly vulnerable to climate change. Their alpine environments also make them vulnerable to disturbance by aircraft and land-based motorized human activity. We reviewed and characterized situations in which goats in close proximity to humans …

Conflict Animals, Or Conflict People—That Is The Question, Vincenzo Penteriani

Human–Wildlife Interactions

Managing conflictual sce­narios involving large carnivores is generally addressed from an animal-centric perspective. This is rather contradic­tory because such conflicts are mostly triggered by human conduct that acts on animal’s instinc­tive behaviors. Shifting conflict miti­gation perspectives to human behaviors may thus provide a more consistent management strategy than focusing only on animals. For example, human habituation and anthropogenic food conditioning are 2 main conflict drivers that mostly depend on human behavior. Thus, an approach that addresses the human dimension aspects of these conflicts needs to be reinforced. I offer 6 points to consider in prioritizing management to mitigate human–bear conflicts …

Hwi Monograph Series

Human–Wildlife Interactions

The HWI Monograph Series includes open access publications on wild pigs, black bears, deer, and a forthcoming title on free-ranging domestic cats.

An Unmanned Aircraft System For Marking Live Power Lines To Prevent Bird Collisions, Mattheuns D. Pretorius, Lourens Leeuwner, Kaajial Durgapersad, Constant Hoogstad, Peter Beckedahl, Michael D. Michael, Kishaylin Chetty

Human–Wildlife Interactions

Collisions with overhead power lines represent a significant cause of mortality for a number of large bird species worldwide. Certain threatened species are severely impacted by power line collisions, particularly those for which there are no other known significant threats. In South Africa, bird collisions with overhead power line cables, including collisions with phase conductors and shield wires, contribute significantly to annual threatened bird species mortalities associated with Eskom power lines. The most practical mitigation measure is to attach bird anti-collision devices as markers on the cables. Current marking methods involve installations by hand, where linemen are hoisted up to …

Effects Of Growth Factor Deprivation On Mkn-45 Spheroid Cells, Özlem Türksoy, Gökhan Terzi̇oğlu

Turkish Journal of Biology

Background/aim: Serum and growth factor deprivation, a common cellular stressor in solid tumors, arises upon irradiation, chemotherapy, and antiangiogenesis. Spheroid body culture aims to enrich cancer stem cells by using low attachment conditions and some growth factors, such as basic fibroblast growth factor and epidermal growth factor to support the spheroid formation in serum-free spheroid culture. However, spheroid culture without any growth factors can imitate the tumor environment more realistically. In this study, we aimed to identify the effect of growth factor deprivation on the MKN-45 gastric cancer cell line in terms of stemness characteristics. Materials and methods: The spheroids …

Understanding Human Gut Bacterial Interactions And Their Role In Colonization Resistance Against Clostridioides Difficile Using Mini-Bioreactor Array And Caenorhabditis Elegans As Model Systems, Achuthan Ambat

Electronic Theses and Dissertations

No abstract provided.