Assessment Of Serum Lipoprotein Phospholipase A2 As An Atherosclerotic Risk Factor In Ischemic Stroke Elderly Patients, Amr Ragab Yousef Ismael, Ahmed Saied, Ahmed Mohamed Elewa, Mohamed Said Gomaa

Mansoura Medical Journal

Background Significant evidence does exist regarding the significant role of inflammation in the development of atherosclerosis. Lipoprotein phospholipase A2 is a phospholipase A2 enzyme (Lp-PLA2) which is predominantly produced by macrophages and lymphocytes in atherosclerotic plaque. Increased Lp-PLA2 concentrations are significantly linked to atherosclerosis-related diseases which include cardiovascular diseases and ischaemic strokes. Aim This study was conducted to assess the role of serum level of Lp-PLA2 in cerebral atherosclerosis. Methods This prospective cross-sectional case-control study enrolled 100 patients aged 60 years old or more with acute ischaemic stroke (AIS). Using the TOAST classification, patients were divided into case group "atherosclerotic” …

Evaluation Of Platelet Indices And Low-Density Lipoprotein (Ldl) As Predictors Of Acute Ischemic Stroke Severity And Outcome, Ahmed E. Al-Sharabi, Ashraf A. El-Mitwalli, Yousra M. Tera, Hossam M. Egila

Mansoura Medical Journal

Background: Platelets play a role in atherosclerosis, inflammation, and thrombosis. Prothrombotic events, activation, aggregation, and adhesion are all increased by elevated mean platelet volume (MPV) and platelet distribution width (PDW) levels; high low-density lipoprotein (LDL) raises the risk of cardiovascular disease. Aims: Investigate the association between platelet indices, lipid profile, stroke severity, and outcome in patients with acute ischemic stroke. ‎ Subjects and methods: A prospective case-control study involved 100 acute ischemic stroke patients and 100 controls from Mansoura University Hospitals. Patients underwent neurological assessments, including the National Institutes of Health Stroke Scale (NIHSS), modified Rankin Scale (mRS), and Alberta …

Effectiveness Of Allergen Immunotherapy In Cigarette Smokers With Allergic Airway Disorders, Heba Wagih Abdelwahab, Mostafa Bakeer, Ahmed Mohamed Fouda

Mansoura Medical Journal

Background: Exposure to environmental tobacco smoke (ETS) is associated with several medical diseases especially allergy, but little is known about the effects of cigarette smoking on allergen immunotherapy response. Aim: This study aims to explore any association between cigarette smoking and response to allergen immunotherapy in patients with allergic airway disorders. Patients and methods: The study was conducted on patients with allergic airway disorders who received subcutaneous immunotherapy. All patients were assessed as regard smoking history including pack-year index and dependence, symptoms and medication scores. Patients’ demographic and clinical data were collected. A statistical analysis was then performed. Results: A …

Ephedrine Versus Norepinephrine Infusion For Prevention Of Haemodynamic Instability After Declamping Of The Aorta In Abdominal Aortic Aneurysm Repair, Mohamed Younes Yousef Abd Allah, Maha Younes Youssef Abd-Allah, Mohamed E. Elshehawi, Ka Awad

Mansoura Medical Journal

Background: During general anesthesia, hypotension is often experienced and is linked to both postoperative morbidity and death. Anesthesiologists have long had a hurdle while performing abdominal aortic aneurysm (AAA) repair, a high-risk treatment that increases vulnerability to hemodynamic disturbances during open surgery. A common vasopressor that is a combined α- and β-agonist, ephedrine is used to treat hypotension in general anesthesia. Conversely, norepinephrine has a favorable chronotropic impact on the heart in addition to acting as an agonist for both α and ß receptors. Aim of the work: Examine the differences in the effects of intravenous ephedrine hydrochloride and noradrenaline …

Inter-Session Repeatability Of Marker-Less Motion Capture Of Treadmill Running Gait, Matthew F. Moran, Isabella C. Rogler, Justin C. Wager

Exercise Science Faculty Publications

Twenty-one experienced runners completed three treadmill running sessions on different days. Each session consisted of three consecutive 2 min trials at self-selected speeds (RPE = 3, 5, and 7). An eight-camera marker-less motion capture system and instrumented pressure treadmill (TM) collected data over the final ~25 s at each speed. Lower extremity joint angles (ankle, knee, and hip) and segmental angles (pelvis and trunk) were computed for each trial with foot contact and toe off being kinematically determined. Spatiotemporal metrics (ground contact time, step length, and cadence) were measured via TM and compared to their kinematically derived counterparts. All spatiotemporal …

Family Income Is Not Significantly Associated With T1w/T2w Ratio In The Human Connectome Project In Development, David G. Weissman, Graham L. Baum, Ashley Sanders, Maya L. Rosen, Deanna M. Barch, Katie A. Mclaughlin, Leah H. Sommerville

Neuroscience: Faculty Publications

Growing evidence indicates that brain development varies as a function of family socioeconomic status (SES). Numer- ous studies have demonstrated that children from low-SES backgrounds have thinner cortex than children from higher- SES backgrounds. A recent study in a large developmental sample found widespread associations between lower SES and greater cortical T1w/T2w ratio—thought to be an indirect proxy for cortical myelin. We evaluated the association of family income with cortical T1w/T2w ratio as a function of age in the Human Connectome Project in Development sample of 989 youth aged 8-21 years. We observed no associations between family income and T1w/ …

Intergenic Transcription In In Vivo Developed Bovine Oocytes And Pre-Implantation Embryos, Saurav Ranjitkar, Mohammad Shiri, Jiangwen Sun, Xiuchun Tian

Computer Science Faculty Publications

Background

Intergenic transcription, either failure to terminate at the transcription end site (TES), or transcription initiation at other intergenic regions, is present in cultured cells and enhanced in the presence of stressors such as viral infection. Transcription termination failure has not been characterized in natural biological samples such as pre-implantation embryos which express more than 10,000 genes and undergo drastic changes in DNA methylation.

Results

Using Automatic Readthrough Transcription Detection (ARTDeco) and data of in vivo developed bovine oocytes and embryos, we found abundant intergenic transcripts that we termed as read-outs (transcribed from 5 to 15 kb after TES) and …

Spatiotemporal Analyses Of Pelagic Sargassum : Biodiversity, Morphotypes And Arsenic Content, Kristie Alleyne

World Maritime University Ph.D. Dissertations

Pelagic sargassum blooming in the Tropical Atlantic has been linked to the mass shoreline inundations observed over the last decade in Caribbean and West African countries. Since the onset in 2011, affected countries have and continue to experience multiscale impacts across fisheries, tourism, nearshore coastal ecosystems, maritime transport and public health. Impacts associated with influx events have generated significant economic damage across the region. Moreover, clean-up efforts in response to mass shoreline strandings placed further strain on national economies and in some instances amplified the negative environmental effects caused by inundations.

Evidence suggests that influx events are likely to continue …

Combatting The Marine Litter Crisis In The Windward Islands : Examining Source-To-Sea Pathways And Fostering Multi-Scale Solutions, Roxanne Elizabeth Donna Graham

World Maritime University Ph.D. Dissertations

This research investigates the intricate and all-pervasive challenge of combatting marine litter in small island developing states (SIDS), specifically in the Wider Caribbean Region (WCR) with a focus on the understudied Windward Islands located in the south-east of the Caribbean. Notably, this research is a ground- breaking and innovative effort in several respects, marking the first time a study of such magnitude and depth has been conducted and published for the WCR and the Windward Islands in particular. This pioneering work thus not only fills a significant gap in the existing literature but also sets a benchmark for future studies …

The Problem Of Abandoned, Lost, And Otherwise Discarded Fishing Gear In Eastern Caribbean Small-Scale Fisheries : Understanding The Challenges, Defining Solutions, Tricia Lovell

World Maritime University Ph.D. Dissertations

/="/">Abandoned, lost, and otherwise discarded fishing gear (ALDFG—also termed derelict fishing gear) is a complex and significant global challenge for which strong, robust, and holistic governance is required. ALDFG is considered the most dangerous form of marine debris, as it is designed to capture marine organisms and can do so long after it has become derelict. While there has been an increasing body of work in academic literature on the scale, impact, and management of ALDFG, significant knowledge gaps still exist about how this challenge is affecting the small-scale fisheries of the Eastern Caribbean. This research has been designed …

Extending Aerial Surveys Beyond Target Marine Mammal Species: An Application Of Strip Transect Methodology To Humpback Whale And Dugong Abundance Estimation In Exmouth Gulf, Western Australia, Jennah Tucker

Theses : Honours

Aerial surveys are commonly used to estimate abundance of marine mammal populations, to detect trends over time and inform conservation management. Estimating abundance in areas critical to a species’ survival and reproduction is important to assess that population’s status and its vulnerability. Aerial surveys allow relatively large areas to be covered over short periods of time which can be important for highly mobile species with wide-ranging movement patterns such as marine mammals. While aerial surveys are often designed for specific target species, information on additional non-target species is often recorded, as surveys are generally infrequent due to expense and logistical …

Experiencing Short Heat Waves Early In Development Changes Thermal Responsiveness Of Turtle Embryos To Later Heat Waves, Anthony Breitenbach, Rosario A. Marroquín-Flores, Ryan T. Paitz, Rachel M. Bowden

Faculty Publications – Biological Sciences

Although physiological responses to the thermal environment are most frequently investigated using constant temperatures, the incorporation of thermal variability can allow for a more accurate prediction of how thermally sensitive species respond to a rapidly changing climate. In species with temperature-dependent sex determination (TSD), developmental responses to incubation temperature are mediated by several genes involved in gonadal differentiation. Kdm6b and Dmrt1 respond to cool incubation temperatures and are associated with testis development, while Foxl2 and Cyp19A1 respond to warm incubation temperatures and are associated with ovary development. Using fluctuating incubation temperatures, we designed two studies, one investigating how conflicting thermal …

The Effect Of Gibberellic Acid Concentration On Gentiana Andrewsii Germination, Laura Spies

Honors Program Theses

Closed Bottle Gentian, Gentiana andrewsii, is an herbaceous flowering plant found in wetland prairies. The seed is difficult to germinate, so it is not on the native seed market. This study determines the optimal concentration of gibberellic acid for this species. The results were accessed based on the morphology changes, germination rates, and survivorship after transplanting. The 50 ppm concentration of gibberellic acid resulted in the highest rate of Gentiana andrewsii germination. The number of seedlings in the experimental group exhibited only slight differences between concentrations. Transplant data shows more significant advantages in determining an optimum concentration. The 50 ppm …

Identification Of A Dna Polymerase Alpha Gene Sequence In Thermomyces Lanuginosus Fungus, Nathan Williams

Honors Program Theses

With cell growth being the main focus of our research, we chose to study DNA polymerase alpha. DNA polymerase alpha is likely to be involved in cell growth as it is the enzyme that starts DNA replication. Control of this enzyme might lead to decreased cell growth in cancer or increased cell growth in damaged spinal cord tissue. We chose the thermophilic fungus Thermomyces lanuginosus for the study of the enzyme due to the ability to compare the enzyme’s activity during fungal growth at different temperatures. Thermomyces exhibits rapid growth at high temperatures and slow growth at low temperatures. Studying …

Monitoring Archaeal Persistence In Cultivation, Payton Hall

Honors Program Theses

It was previously thought that microbes in the domain Archaea were only found in extreme environments such as hot thermal vents at the bottom of the ocean and hypersaline environments, but as scientists began to use environmental DNA to survey soil, they detected archaea from the phylum Thaumarchaeota in relatively benign environments including farm fields, forests, and prairies. In spite of their widespread global distribution, relatively few of these species have been grown in laboratory culture. It is now known that Thaumarchaeota play an important role in the nitrogen cycle because they can generate energy through ammonia-oxidation. To increase the …

Evaluation Of Methods To Analyze Microbial Composition In Soils, Joseph Correa

Honors Program Theses

DNA testing has become a vital tool for studying microbes in their natural environments, but there is a lack of standardization in the protocols for extracting environmental DNA. Cave systems provide a special and unique area to research how life thrives in extreme environments. Many parts of caves receive no sunlight and very little nutrients yet harbor microbial communities. Previous work in our lab developed a DNA extraction protocol that works with a wide range of microbial species and with different soil types. I updated this protocol by adding a pre-lysis rinse step and tested whether it performed better with …

A Picture Worth A Thousand Words: Factors Influencing Disability Accommodations, Alicia E. Martin

Cal Poly Humboldt theses and projects

Because not all disabilities look the same it is difficult to label a person with disabilities just by looking at them. Given that our knowledge, attitudes, and perceptions impact how we interpret our world and our willingness to act, people, including professors, may be biased toward providing accommodations for those with easily recognizable disabilities and biased against those with non-recognizable disabilities, and this may impact the disabled person’s ability to learn. This thesis aims to address whether professors’ disability-related attitudes, perceptions of accommodation reasonableness, and willingness to provide accommodations differ when the disability is recognizable (student is pictured in a …

Is The Area Postrema Resistant To The Anesthetic Effects Of Ms-222?, Austin T. Csiszar

Cal Poly Humboldt theses and projects

MS-222 is a common fish anesthetic that dampens neural activity by inhibiting neuronal voltage-gated sodium channels (Na_v) required for action potentials. Previous experiments conducted by our lab’s primary investigator using fluorescence calcium imaging in zebrafish neurons resulted in the observation that neurons in the area postrema (AP), a circumventricular organ located in the dorsal hindbrain, displayed prominent fluorescence intensity during MS-222 induced sedation. I used the genetically encoded calcium indicator GCaMP6s to conduct fluorescence calcium imaging with the goal of recording neural activity in the larval zebrafish area postrema and optic tectum to compare the anesthetic effects of …

Inferring Exposure To Harmful Pseudo-Nitzschia Blooms From Ocean-To-Estuary Gradients In Domoic Acid Concentrations In Humboldt Bay Bivalves, Natasha Hope Ficzycz Winnacott

Cal Poly Humboldt theses and projects

Harmful algal blooms (HABs) result from outbreaks of any of several different species of toxin-producing phytoplankton and that can have major detrimental effects on marine ecosystems and pose severe health and economic threats to human communities. Of particular concern along the United States West Coast are HABs of pennate diatom genus Pseudo-nitzschia that produce the potent neurotoxin domoic acid (DA). The coastal ocean between Cape Mendocino, CA, and Cape Blanco, OR is a hotspot for Pseudo-nitzschia spp. HABs. Such blooms impact coastal fisheries and pose a potential threat to aquaculture operations in Humboldt Bay, California’s second largest estuary and largest …

The Effects Of Aquatic Programs On Students With Disabilities Fitness And Skill-Based Outcomes; A Meta-Analysis, Delaney Hughes

Cal Poly Humboldt theses and projects

The purpose of the meta-analysis was to determine the impact of aquatic-based interventions on health-related fitness and skill-based outcomes for children with disabilities. PRISMA guidelines were used to complete the procedures of the meta-analysis. Twenty-three studies met the inclusion criteria and results indicate that overall, aquatic programming likely positively affects students with disabilities and health-related fitness outcomes. Recommendations provide direction for future studies to help improve intervention results.

Macrolichen Inventory Of The Horse Mountain Botanical Area, Six Rivers National Forest, California, Usa, Sarah Norvell Conway

Cal Poly Humboldt theses and projects

Macrolichen diversity and community composition was determined for an area of high botanical interest in the Coast Ranges of Northern California – the Horse Mountain Botanical Area (HMBA) in Six Rivers National Forest. The Coast Ranges have been suggested to have high epiphytic macrolichen diversity, yet detailed site-specific macrolichen surveys are lacking for the area. Here we present comprehensive data on macrolichens of the HMBA integrated with environmental metadata at the landscape level. Twenty 0.4 ha sampling plots were positioned across the varying habitats of the HMBA and macrolichens were intensively sampled from all substrata. Out of 888 total collections, …

Diversity And Distribution Of Bryozoans Of The Northern To Central Rocky Outer Coast Of California, Ismael Chowdhury

Cal Poly Humboldt theses and projects

The phylum Bryozoa is one of the most diverse groups of marine invertebrates, with a global distribution that spans marine and fresh waters. This study analyzes the Bryozoa in infralittoral communities on rocky surfaces from northern California (Point Saint George) to central California (Estero Bay), spanning 940 kilometers and encompassing 12 rocky intertidal sites. Although recent studies on bryozoan taxonomy and phylogeny have increased due to scanning electron microscopy (SEM) and high throughput sequencing, there is still a lack of studies on species found in shallow waters at intertidal depths, particularly in the northeastern Pacific. This study aims to expand …

Using Multiscale Ensemble Habitat Models To Identify Wildfire Risk To Habitat For An Iconic Forest Species, Logan Baker Hysen

Cal Poly Humboldt theses and projects

Large and severe wildfires, exacerbated by climate change and human behavior, are occurring more frequently in many forests across the western United States. While wildfire is a natural part of most terrestrial ecosystems, rapidly changing fire regimes have the potential to alter habitat beyond the adaptive capabilities of species. Spatial assessments of wildfire risks to species habitat may allow managers to pinpoint locations for management activities. To illustrate this, I spatially assessed wildfire risk within habitat that supports the nesting activity of the federally threatened northern spotted owl (Strix occidentalis caurina) in the California redwood coast ecoregion. To …

Seasonal Growth, Movement, And Survival Of Juvenile Coho Salmon (Oncorhynchus Kisutch) Utilizing Restored Rearing Habitat, Monica S. Tonty

Cal Poly Humboldt theses and projects

The Scott River supports the most robust population of threatened Coho Salmon Oncorhynchus kisutch remaining in the Klamath River basin. Even in the Scott River, low quality and restricted extent of juvenile rearing habitat limits the Coho Salmon population to a small fraction of historic abundance. To support persistence and recovery of Scott River Coho Salmon, the Scott River Watershed Council (SRWC) has constructed a portfolio of restoration projects to improve juvenile rearing habitat, including beaver dam analogs (BDAs). The Scott River BDAs were the first implemented anywhere in California. This study compares juvenile Coho Salmon responses associated with production …

The Benefits Of Physical Education Programs For Students In Special Education Programs With Attention Deficit Hyperactivity Disorder, Deborah A. Mok

Cal Poly Humboldt theses and projects

Researchers have reported that exercise has had positive results on decreasing many behaviors for children with ADHD. The purpose of this study is to examine the impact of a structured physical education program for students in grades K-4 with attention deficit hyperactivity disorder (ADHD) on academic performance. This study utilized a single subject withdrawal design. Four participants attending a special day class in grades K-4 in Northern California participated in this study. Results of this study demonstrated that 30 minutes of structured physical activity had a positive impact on decreasing the number of off-task behaviors for all four of the …

Defining And Exploring Animal Sentience, Andrew N. Rowan, Joyce M. D'Silva Mrs, Ian J.H. Duncan, Nicholas Palmer

Animal Sentience

One of the commentaries on the target article notes that "animal sentience" is difficult to define operationally. This response to the commentaries develops a working, usable definition of animal sentience and examines the relationships between animal emotions and sentience.

A Novel Digital Digit-Symbol Substitution Test Measuring Processing Speed In Adults At Risk For Alzheimer Disease: Validation Study, Anthony Campitelli, Sally Paulson, Josh L. Gills, Megan D. Jones, Erica N. Madero, Jennifer Myers, Jordan M. Glenn, Michelle Gray

Health, Human Performance and Recreation Faculty Publications and Presentations

Background: Assessing cognitive constructs affected by Alzheimer disease, such as processing speed (PS), is important to screen for potential disease and allow for early detection. Digital PS assessments have been developed to provide widespread, efficient cognitive testing, but all have been validated only based on the correlation between test scores. Best statistical practices dictate that concurrent validity should be assessed for agreement or equivalence rather than using correlation alone.

Objective: This study aimed to assess the concurrent validity of a novel digital PS assessment against a gold-standard measure of PS.

Methods: Adults aged 45-75 years (n=191) participated in this study. …

Association Of The Bb Genotype Of The Abo Gene With The Risk Of Acute Myocardial Infarction In Hospital-Based Study, Farzana Abubakar Yousuf, Iqbal Azam Syed, Asal Khan Tareen, Khawar A. Kazmi, Jibran Sualeh Muhammad, Mohammad Perwaiz Iqbal

Department of Biological & Biomedical Sciences

Objectives: The ABO gene locus has been identified to be associated with myocardial infarction in patients with coronary heart disease. The primary focus of this hospital-based study was to explore the relationship of ABO blood groups and ABO genotypes with acute myocardial infarction (AMI) in Karachi, Pakistan.
Methods: In a comparative cross-sectional study, an equal number of adult AMI patients and healthy controls (n=275 in each group; age range 30-70 years, both males and females) were recruited from the Aga Khan University and NICVD, Karachi, with informed consent. The blood samples were analyzed for ABO blood groups and other biomarkers. …

Evaluating Blood Pressure And Hypertension Awareness In Municipal Workers In The Southeast Us, Kayden R. Mcalvin

College of Graduate Studies: Theses & Dissertations

The primary purpose of this study was to describe municipal workers’ blood pressure (BP) status and awareness; the secondary purpose was to examine the association between BP misconception and department. Municipal employees in a southeastern rural community (n=75) were asked to participate in a 15-minute survey, including the BASIS Hypertension Awareness survey, and blood pressure measurements to determine hypertension risk. Results show a significant difference in diastolic blood pressure (DBP) between police with a higher DBP of 87.64 ± 10.9 mm Hg and fire departments 78.98 ± 11.1 mm Hg (p=0.005), a significant difference in DBP between city hall/public works …

Hepatic Transcriptomic Assessment Of Sprague Dawley Rats In Response To Dietary Perfluorobutane Sulfonate (Pfbs) Ingestion, Isaac Appiah

College of Graduate Studies: Theses & Dissertations

Perfluorobutane sulfonate (PFBS) is a short-chain PFAS that is considered to be a less toxic replacement for the rather more toxic long-chain perfluorooctane sulfonate (PFOS). Its numerous industrial applications and widespread presence in the environment have raised environmental and health concerns because of growing evidence associating adverse health effects and certain liver diseases to PFBS exposure. The study goal was to investigate whether dietary ingestion of PFBS would induce liver injuries, damage, inflammations, and oxidative stress. To achieve these goals, Sprague-Dawley rats were assigned into three PFBS dietary treatment groups (0, 50, and 100 PPM) for 11 weeks. After this …