Life Sciences Commons^™

New Records Of Distribution And Natural History Of Vertebrates In Arkansas: 2020-2023, R. Tumlison, H.W. Robison, M.B. Connior, D.B. Sasse, T.S. Risch, K. Edmonds, J.D. Wilhide, C.R. Allen

Journal of the Arkansas Academy of Science

Small details of natural history often go undocumented to science if those details are not parts of larger studies. However, knowledge of small details can provide insights that lead to interesting questions about ecological relationships or environmental change. We have compiled recent important observations of natural history of vertebrates, including several distributional and size records of fishes, atypical carapace shape in a common snapping turtle, an unusual support structure for a bird nest, healed damage to a broken jaw of a young deer, and numerous distributional records of bats.

Wa Insecticide Guide 2023 - Winter Spring, Rebecca Severtson, Alan Lord

PestFacts WA

Registered chemicals for broadacre crops in Western Australia.

The insecticides listed in the tables within this guide can be used on any crop appearing on the chemical label, if the rate used does not exceed the highest rate that is registered for use on that crop.

There are many products with different trade names that contain the same active ingredient. This list is not exhaustive and does not imply any specific recommendations of brand names.

Unless otherwise specified all insecticides listed are emulsifiable concentrate (EC). Insecticides with SC are suspension concentrate, WP is wettable powder, CS is capsule suspension, WG …

Can Testing The Environment For Severe Acute Respiratory Coronavirus Virus 2 (Sars-Cov-2) Be A Signal For Coronavirus Disease 2019 (Covid-19) Cases Among Nursing Home Staff?, Gabrielle M. Gussin, Raveena D. Singh, Izabela Coimbra Ibraim, Raheeb Saavedra, Thomas T. Tjoa, Micaila Curtis, Kristine P. Nguyen, Ilhem Messaoudi, Susan S. Huang

Microbiology, Immunology, and Molecular Genetics Faculty Publications

Prior to widespread COVID-19 vaccination, nursing homes were required to perform comprehensive weekly testing of staff. After the vaccine became available, testing became symptom-based for vaccinated staff despite continued waves of different severe acute respiratory coronavirus virus 2 (SARS-CoV-2) variants. Nursing homes need pragmatic, affordable strategies to identify SARS-CoV-2–positive staff because financial and job-related pressures drive reluctance to disclose mild symptoms. We sought to determine whether positive environmental samples for SARS-CoV-2 could serve as trigger for comprehensive staff testing in lieu of weekly testing of all staff.

Correlates Of Sars-Cov-2 Anti-Rbd Igg Antibody Titers Among Persons Experiencing Homelessness In Los Angeles, Adeline Nyamathi, Sanghyuk S. Shin, Brianna M. Doratt, Alexandria Jones-Patten, Benissa Salem, Lillian Gelberg, Darlene Lee, Dana Garfin, Kartik Yadav, Alicia H. Chang, Kathryn White, Nicholas Arce, Ilhem Messaoudi

Microbiology, Immunology, and Molecular Genetics Faculty Publications

Objectives: People experiencing homelessness (PEH) have been especially impacted by the COVID-19 pandemic, likely due to increased vulnerabilities stemming from chronic diseases, substance use, and mental health conditions.

Design: A case–control study to assess the presence of antibodies against SARS-CoV-2 among PEH and associations with key variables.

Sample: A convenience sample of 97 PEH in Skid Row, Los Angeles.

Measurements: A structured questionnaire assessing socio-demographic, mental health, drug and alcohol use, health care access, pandemic stress, and other COVID-19-specific questions.

Results: We found high anti-receptor binding domain (RBD) IgG titers among five of 15 PEH who reported no prior COVID-19 …

Maternal Obesity Blunts Antimicrobial Responses In Fetal Monocytes, Suhas Sureshchandra, Brianna M. Doratt, Norma Mendza, Oleg Varlamov, Monica Rincon, Nicole E. Marshall, Ilhem Messaoudi

Microbiology, Immunology, and Molecular Genetics Faculty Publications

Maternal pre-pregnancy (pregravid) obesity is associated with adverse outcomes for both mother and offspring. Amongst the complications for the offspring is increased susceptibility and severity of neonatal infections necessitating admission to the intensive care unit, notably bacterial sepsis and enterocolitis. Previous studies have reported aberrant responses to LPS and polyclonal stimulation by umbilical cord blood monocytes that were mediated by alterations in the epigenome. In this study, we show that pregravid obesity dysregulates umbilical cord blood monocyte responses to bacterial and viral pathogens. Specifically, interferon-stimulated gene expression and inflammatory responses to respiratory syncytial virus (RSV) and E. coli were significantly …

Sars-Cov-2 Infection And Seroconversion Rates In Healthcare Providers Prior To Covid-19 Vaccine Rollout, Sanghyuk S. Shin, Miriam Bender, Delphine C. Malherbe, Hannah Vasquez, Brianna M. Doratt, Ilhem Messaoudi

Microbiology, Immunology, and Molecular Genetics Faculty Publications

Objective: A 6-month longitudinal surveillance study of asymptomatic healthcare providers (HCP) was carried out at a large urban academic medical center in the United States to assess whether their job occupation with higher exposure risks to SARS-CoV-2 would equate with higher risk of contracting COVID-19 at the beginning of the pandemic before COVID-19 vaccines were available.

Methods: A longitudinal cohort study design was used to collect and analyze immunological and virological monitoring data and self-report survey assessments of personal protective equipment (PPE) availability, adherence to infection control guidelines, and time spent on COVID-19 wards.

Results: Among 289 eligible participants, SARS-CoV-2 …

Single-Dose Vsv-Based Vaccine Protects Cynomolgus Macaques From Disease After Taï Forest Virus Infection, Paige Fletcher, Kyle L. O'Donnell, Brianna M. Doratt, Delphine C. Malherbe, Chad S. Clancy, Joseph F. Rhoderick, Friederike Feldmann, Patrick W. Hanley, Thomas G. Ksiazek, Thomas W. Geisbert, Ilhem Messaoudi, Andrea Marzi

Microbiology, Immunology, and Molecular Genetics Faculty Publications

Taï Forest virus (TAFV) is a lesser-known ebolavirus that causes lethal infections in chimpanzees and is responsible for a single human case. Limited research has been done on this human pathogen; however, with the recent emergence of filoviruses in West Africa, further investigation and countermeasure development against this virus is warranted. We developed a vesicular stomatitis virus (VSV)-based vaccine expressing the TAFV glycoprotein as the viral antigen and assessed it for protective efficacy in nonhuman primates (NHPs). Following a single high-dose vaccination, NHPs developed antigen-specific binding and neutralizing antibodies as well as modest T cell responses. Importantly, all vaccinated NHPs …

Transcriptional Profiling Of Immune Responses In Nhps After Low-Dose, Vsv-Based Vaccination Against Marburg Virus, Cecilia A. Prator, Brianna M. Doratt, Kyle L. O'Donnell, Justin Lack, Amanda N. Pinski, Stacy M. Ricklefs, Craig A. Martens, Ilhem Messaoudi, Andrea Marzi

Microbiology, Immunology, and Molecular Genetics Faculty Publications

Infection with Marburg virus (MARV), the causative agent of Marburg virus disease (MVD), results in haemorrhagic disease and high case fatality rates (>40%) in humans. Despite its public health relevance, there are no licensed vaccines or therapeutics to prevent or treat MVD. A vesicular stomatitis virus (VSV)-based vaccine expressing the MARV glycoprotein (VSV-MARV) is currently in clinical development. Previously, a single 10 million PFU dose of VSV-MARV administered 1–5 weeks before lethal MARV challenge conferred uniform protection in nonhuman primates (NHPs), demonstrating fast-acting potential. Additionally, our group recently demonstrated that even a low dose VSV-MARV (1000 PFU) protected NHPs …

Best3-Mediated Mekk2/3 Activation: A Novel Therapeutic Target In Aortopathies, Tatiana Zyrianova, Benjamin Lopez, Kathlyn Zou, Charles Gu, Dayna Pham, Sriharsha Talapaneni, Christopher M. Waters, Riccardo Olcese, Andreas Schwingshackl

Saha Cardiovascular Research Center Faculty Publications

Influenza-A virus (IAV) infects yearly an estimated one billion people worldwide, resulting in 300,000–650,000 deaths. Preventive vaccination programs and antiviral medications represent the mainstay of therapy, but with unacceptably high morbidity and mortality rates, new targeted therapeutic approaches are urgently needed. Since inflammatory processes are commonly associated with measurable changes in the cell membrane potential (Em), we investigated whether Em hyperpolarization via TREK-1 (K2P 2.1) K þ channel activation can protect against influenza-A virus (IAV)-induced pneumonia. We infected mice with IAV, which after 5 days caused 10–15% weight loss and a decrease in spontaneous activity, representing a clinically relevant infection. …

Condition Factor And Length-Weight Relationships Evaluation Of 15 Oxynoemacheilus Species (Cypriniformes: Nemacheilidae) From Iran, Atta Mouludi-Saleh, Soheil Eagderi, Erdoğan Çi̇çek, Edris Ghaderi

Turkish Journal of Zoology

This study was conducted to determine the relationship between the length and weight (LWR) of 15 Oxynoemacheilus species i.e. Oxynoemacheilus bergianus, O. brandtii, O. chomanicus, O. euphraticus, O. elsae, O. frenatus, O. karunensis, O. kiabii, O. kurdistanicus, O. longipinnis, O. parvinae, O. persa, O. marunensis, O. zagrosensis, and O. zarzianus from Iranian inland waters. LWRs with high coefficients of determination were calculated for all species. The values of the slope parameter (b) ranged from 2.225 in O. brandtii to 3.575 in O. euphraticus. Fulton's condition factor (K$_{F}$) ranged from 0.673 in O. persa to 1.407 in O. kiabili …

International Society Of Sports Nutrition Position Stand: Ketogenic Diets, Arny A. Ferrando, Robert R. Wolfe, Katie R. Hirsch Phd,Ep-C, Cissn, David D. Church, Shiloah A. Kviatkovsky, Michael D. Roberts, Jeffrey R. Stout, Drew E. Gonzalez, Ryan J. Sowinski, Richard B. Kreider, Chad M. Kerksick, Nicholas A. Burd, Stefan M. Pasiakos, Michael J. Ormsbee, Shawn M. Arent Ph.D., Cscs*D, Fissn, Facsm, Fnak, Paul J. Arciero, Bill I. Campbell, Trisha A. Vandusseldorp, Ralf Jager, Darryn S. Willoughby, Douglas S. Kalman, Jose Antonio

Faculty Publications

Position Statement: The International Society of Sports Nutrition (ISSN) presents this position based on a critical examination of literature surrounding the effects of essential amino acid (EAA) supplementation on skeletal muscle maintenance and performance. This position stand is intended to provide a scientific foundation to athletes, dietitians, trainers, and other practitioners as to the benefits of supplemental EAA in both healthy and resistant (aging/clinical) populations. EAAs are crucial components of protein intake in humans, as the body cannot synthesize them. The daily recommended intake (DRI) for protein was established to prevent deficiencies due to inadequate EAA consumption. The following conclusions …

International Society Of Sports Nutrition Position Stand: Energy Drinks And Energy Shots, Andrew R. Jagim, Patrick S. Harty, Grant M. Tinsley, Chad M. Kerksick, Adam M. Gonzalez, Richard B. Kreider, Shawn M. Arent Ph.D., Cscs*D, Fissn, Facsm, Fnak, Ralf Jager, Abbie E. Smith-Ryan, Jeffrey R. Stout, Bill I. Campbell, Trisha Vandusseldorp, Jose Antonio

Faculty Publications

Position Statement: The International Society of Sports Nutrition (ISSN) bases the following position stand on a critical analysis of the literature regarding the effects of energy drink (ED) or energy shot (ES) consumption on acute exercise performance, metabolism, and cognition, along with synergistic exercise-related performance outcomes and training adaptations. The following 13 points constitute the consensus of the Society and have been approved by the Research Committee of the Society: Energy drinks (ED) commonly contain caffeine, taurine, ginseng, guarana, carnitine, choline, B vitamins (vitamins B1, B2, B3, B5, B6, B9, and B12), vitamin C, vitamin A (beta carotene), vitamin D, …

Determination Of The Effects Of Added Methionine On The Toxicity Of Platinum Drugs In Saccharomyces Cerevisiae, Kassidy Owens, Jonathan White

Longwood Senior Thesis Proposal

Platinum (Pt) drugs are used in about half of all anticancer treatments. A common way to study Pt drugs is by using S. cerevisiae (brewer’s yeast) as a model cellular organism. One of the most commonly-used strains of yeast is BY4741, which is auxotrophic for (cannot synthesize) several small-molecule nutrients, including the amino acid methionine. Therefore, methionine must be supplemented in the cell culture medium. Interestingly, it is known that methionine can react with Pt compounds, including Pt drugs. Methionine-supplemented media continues to be used to study Pt drugs in yeast, especially BY4741, yet the potential for methionine to interfere …

What Costimulatory Domains In Chimeric Antigen Receptor T Cells Induce The Strongest Killing Response And Increase Serial Killing Efficacy Against Pediatric Rhabdomyosarcomas And Osteosarcomas?, Kristen Wilkins

Longwood Senior Thesis Proposal

No abstract provided.

Investigating Visinin-Like Protein 1 And Ubiquitinated Visinin-Like Protein 1 As Mild Traumatic Brain Injury Biomarkers, Yueming Wu

Theses and Dissertations--Chemistry

Traumatic brain injury (TBI) continues to be a significant cause of morbidity and mortality worldwide. Despite significant progress in understanding the complex pathophysiology of TBI, the underlying mechanisms remain poorly understood. The primary brain damage is acute and irreversible. However, secondary brain injuries often develop gradually over months to years, creating an opportunity for critical therapeutic interventions. In the past decade, research on TBI biomarkers has seen significant progress. This progress has been driven by the diverse nature of TBI pathologies and the challenges they present for evaluation, management, and prognosis. TBI biomarker proteins resulting from axonal, neuronal, or glial …

Quantifying Residual Feed In A Fence-Line Feedlot Bunk Using Depth Camera Imaging Techniques, Jean Niwenshuti, Galen E. Erickson, Tami M. Brown-Bandl, Eric T. Psota, Yijie Xiong

Nebraska Beef Cattle Reports

Feed bunk management requires intensive labor and relies on manual observation to estimate the amount of residual feed in the bunk. Alternative and innovative technologies were used to estimate the weight of residual feed in a concrete fence-line bunk using a depth camera. Depth cameras capture the distance between the camera and the object in their field of view. This study used a time-of-flight depth camera (Azure Kinect, Microsoft) to estimate the weight of residual feed in a partial fence-line concrete bunk using 11 common feed ingredients. The camera was fastened approximately 3.3 ft above the center of the bunk …

Extending Melengestrol Acetate Treatment From Fourteen To Eighteen Days In Beef Heifers, Dempster Christenson, Jordan M. Thomas, Daniel J. Kelly, R. Funston

Nebraska Beef Cattle Reports

This study compared estrus synchronization, estrus response, and artificial insemination pregnancy rates of beef heifers fed melengestrol acetate the normal 14-day period or extended to an 18-day period using the melengestrol acetate -prostaglandin- heat detect and timed artificial insemination protocol. Therefore, the purpose of this study was to evaluate if extending melengestrol acetate feeding by 4 days increases the number of heifers ovulating, which would result in greater estrus response and pregnancy rate in the whole herd. Early estrus response following prostaglandin administration occurred in heifers who averaged an earlier estrus response after melegestrol acetate withdrawal but extending the melengestrol …

Long-Range Aceo Phenomena In Microfluidic Channel, Diganta Dutta, Keifer Smith, Xavier Palmer

Electrical & Computer Engineering Faculty Publications

Microfluidic devices are increasingly utilized in numerous industries, including that of medicine, for their abilities to pump and mix fluid at a microscale. Within these devices, microchannels paired with microelectrodes enable the mixing and transportation of ionized fluid. The ionization process charges the microchannel and manipulates the fluid with an electric field. Although complex in operation at the microscale, microchannels within microfluidic devices are easy to produce and economical. This paper uses simulations to convey helpful insights into the analysis of electrokinetic microfluidic device phenomena. The simulations in this paper use the Navier–Stokes and Poisson Nernst–Planck equations solved using COMSOL …

Mapping Genetic Variation In Arabidopsis In Response To Plant Growth-Promoting Bacterium Azoarcus Olearius Dqs-4t, Fernanda Plucani Do Amaral, Juexin Wang, Jacob Williams, Thalita R. Tuleski, Trupti Joshi, Marco A. R. Ferreira, Gary Stacey

Biomedical Sciences

Plant growth-promoting bacteria (PGPB) can enhance plant health by facilitating nutrient uptake, nitrogen fixation, protection from pathogens, stress tolerance and/or boosting plant productivity. The genetic determinants that drive the plant–bacteria association remain understudied. To identify genetic loci highly correlated with traits responsive to PGPB, we performed a genome-wide association study (GWAS) using an Arabidopsis thaliana population treated with Azoarcus olearius DQS-4^T. Phenotypically, the 305 Arabidopsis accessions tested responded differently to bacterial treatment by improving, inhibiting, or not affecting root system or shoot traits. GWA mapping analysis identified several predicted loci associated with primary root length or root fresh …

Accucalc: A Python Package For Accuracy Calculation In Gwas, Jana Biová, Nicholas Dietz, Yen On Chan, Trupti Joshi, Kristin Bilyeu, Mária Škrabišová

Biomedical Sciences

The genome-wide association study (GWAS) is a popular genomic approach that identifies genomic regions associated with a phenotype and, thus, aims to discover causative mutations (CM) in the genes underlying the phenotype. However, GWAS discoveries are limited by many factors and typically identify associated genomic regions without the further ability to compare the viability of candidate genes and actual CMs. Therefore, the current methodology is limited to CM identification. In our recent work, we presented a novel approach to an empowered “GWAS to Genes” strategy that we named Synthetic phenotype to causative mutation (SP2CM). We established this strategy to identify …

Plant Sentience Revisited: Sifting Through The Thicket Of Perspectives, Paco Calvo, Miguel Segundo-Ortin

Animal Sentience

In our target article (Segundo-Ortin & Calvo 2023), we proposed the intriguing possibility of plant sentience, drawing parallels with non-human animal studies. This response aims to sift through the rich thicket of perspectives offered by our commentators. To do so, we assess the risks of employing double standards, as well as the tendencies of anthropomorphizing and zoomorphizing in plant studies. We also emphasize the need for clarity in linguistic and conceptual terms, examine the neurophysiological evidence for plant sentience, and discuss the ethical implications of such recognition.

The Psychology Of Science Denialism And Lessons For Public Health Authorities, Brenna Moreno, Molly J. Walker Wilson

All Faculty Scholarship

As it wreaked tragedy on the world, the outbreak of COVID-19 helped expose a pandemic of a different kind, one steeped in distrust and contrarianism. This movement, termed science denialism, has been lurking and undermining public health efforts for decades. Specifically, it is “the employment of rhetorical arguments to give the appearance of legitimate debate where there is none, an approach that has the ultimate goal of rejecting a proposition on which a scientific consensus exists.” Unlike skepticism, which is “doubt as to the truth of something” and works to progress both science and society, denialism is characterized by individuals’ …

Implications Of An Exogenous Shock (Covid-19) On Wine Tourism Business: A Portuguese Winery Perspective, Alexandre Guedes, Britta Niklas, Robin M. Back, Joao Rebelo

Faculty Scholarship and Creative Works

This study investigates the impact of an exogenous and unexpected shock (COVID-19) on the wine tourism business from the winery's perspective. A sample of 146 Portuguese wineries was surveyed. The econometric results show that the share of wine tourism sales, the amount of dependence on exports and the assertiveness of brand recognition have a structural effect on direct-to-consumer tasting room wine sales, even when the winery's business is disrupted by a shock that degrades the dynamics and flows of international trade. The research establishes a starting point that allows to understand the implications of an exogenous shock on the structure …

Vibes: A Workflow For Annotating And Visualizing Viral Sequences Integrated Into Bacterial Genomes, Conner J. Copeland

Graduate Student Theses, Dissertations, & Professional Papers

Bacteriophages are viruses that infect bacteria. Many bacteriophages integrate their genomes into the bacterial chromosome and become prophages. Prophages may substantially burden or benefit host bacteria fitness, acting in some cases as parasites and in others as mutualists, and have been demonstrated to increase host virulence. The increasing ease of bacterial genome se- quencing provides an opportunity to deeply explore prophage prevalence and insertion sites. Here we present VIBES, a workflow intended to automate prophage annotation in complete bacterial genome sequences. VIBES provides additional context to prophage annotations by annotating bac- terial genes and viral proteins in user-provided bacterial and …

The Effects Of Weather On Facilitating The Intensification And Collapse Of Bark Beetle Outbreaks In Ponderosa Pine Forests Of The Northern Rocky Mountains And The Black Hills, Jordan T. Lestina

Graduate Student Theses, Dissertations, & Professional Papers

Bark beetles are a diverse family of insect herbivores, of which the most aggressive species can cause significant tree mortality, and are integral components of disturbance regimes in conifer dominated forests of North America. Recent drought events across the western U.S. have been broadly associated with the initiation of multiple bark beetle outbreaks in ponderosa pine forests during the last two decades. Changing weather conditions, such as those observed during the onset of drought, affect outbreak progression through their influence on bark beetle physiology and life history traits and the overall vigor and defensiveness of host trees. This study used …

Review Of The Valorization Initiatives Of Brewing And Distilling Byproducts, Ekene C. Umego, Catherine Barry-Ryan

Articles

Beer and spirits are two of the most consumed alcoholic beverages in the world, and their production generates enormous amounts of by-product materials. This ranges from spent grain, spent yeast, spent kieselguhr, trub, carbon dioxide, pot ale, and distilled gin spent botanicals. The present circular economy dynamics and increased awareness on resource use for enhanced sustainable production practices have driven changes and innovations in the management practices and utilisation of these by-products. These include food product development, functional food applications, biotechnological applications, and bioactive compounds extraction. As a result, the brewing and distilling sector of the food and drinks industry …

Novel Biorefinery Process For Extraction Of Laminarin, Alginate And Protein From Brown Seaweed Using Hydrodynamic Cavitation, Xianglu Zhu, Laura Healy, Rahel Suchintita Das, M.L. Bhavya, Shanmugapriya Karuppusamy, Da-Wen Sun, Colm O'Donnell, Brijesh K. Tiwari

Articles

This paper investigates a novel biorefinery process designed for the extraction of valuable compounds from brown seaweed Alaria esculenta using hydrodynamic cavitation (HDC). A two-stage process was developed to maximize the value of seaweed biomass by control of the processing time, solvent selection and HDC conditions to extract laminarin, alginate, mannitol and protein in a cascading manner, maximizing the value of seaweed biomass. After the first extraction stage using 0.1 M HCl, membrane ultrafiltration was employed to separate laminarin and mannitol. The purity of the laminarin and mannitol obtained was up to 86.57 ± 3.72 % and 40.49 ± 2.78 …

Recent Insights On The Conformational Changes, Functionality, And Physiological Properties Of Plant-Based Protein–Polyphenol Conjugates, Mehnaza Manzoor, Zaria Fozonne Ngabou Tchameni, Zuhaib F. Bhat, Amit K. Jaiswal, Sundeep Jaglan

Articles

Plant proteins are promising sources of nutrition with enhanced health benefits due to their interaction with bioactive compounds like polyphenols. These interactions can form protein–polyphenol complexes with diverse properties and applications in the food, nutraceutical, and pharmaceutical industries. To exploit the potential of these conjugates, it is essential to understand how they are formed, characterized, and delivered. Various techniques such as spectroscopy, thermodynamics, and molecular docking simulations can reveal the mechanism and outcomes of protein–polyphenol binding. Moreover, the surface modification of protein–polyphenol conjugation can enhance the pharmacological effects of different drug molecules and enable their targeted delivery to specific tissues …

Physicochemical, Technofunctional, In Vitro Antioxidant, And In Situ Muscle Protein Synthesis Properties Of A Sprat (Sprattus Sprattus) Protein Hydrolysate, Niloofar Shekoohi, Azza Silotry Naik, Miryam Amigo Benevent, Padraigin A. Harnedy-Rothwell, Brian P. Carson, Richard J. Fitzgerald

Articles

This study characterized the physicochemical, technofunctional, and in vitro antioxidant properties along with the AA profile and score of a sprat protein enzymatic hydrolysate (SPH). Furthermore, the impact of the SPH on the growth, proliferation, and muscle protein synthesis (MPS) in skeletal muscle (C2C12) myotubes was examined. The SPH displayed good solubility and emulsion stabilization properties containing all essential and non-essential AAs. Limited additional hydrolysis was observed following in vitro-simulated gastrointestinal digestion (SGID) of the SPH. The SGID-treated SPH (SPH-SGID) displayed in vitro oxygen radical antioxidant capacity (ORAC) activity (549.42 μmol TE/g sample) and the ability to reduce (68%) reactive …

Novel Feature Evaluation In Ultra-High Dimensional Right-Censored Data, With Applications To Head And Neck Cancer, Atika Farzana Urmi

Graduate Research Posters

Background: Head and neck cancer is the 6th most common cancer worldwide with an expected 1.08 million new cases each year. Such cancer data are ultra-high dimensional with thousands of clinical features and gene expressions, making it challenging for the traditional analytical tools to extract the potential biomarker for the cancer survival and control false discoveries. In addition, presence of heavy censoring can affect the screening procedures based on Kaplan-Meier (K-M) survival estimates.

Aim: To propose a model free, ultra-high dimensional feature screening method with two-dimensional survival outcome allowing false discovery rate (FDR) control.

Method: 516 primary tumor patients with …