Life Sciences Commons^™

Description Of A New Species Of Stenocrates Burmeister (Coleoptera: Scarabaeidae: Dynastinae: Cyclocephalini) From Peru And A Revised Catalog Of The Species Of Stenocrates., Brett C. Ratcliffe, Stephane Le Tirant

Department of Entomology: Faculty Publications

A new species of the South American genus Stenocrates Burmeister, 1847 (Coleoptera: Scarabaeidae: Dynastinae: Cyclocephalini) is described: Stenocrates theryi Ratcliffe & Le Tirant from western Peru. A description, diagnosis, distribution, and illustrations are provided for the new species. A revised catalog of the species of Stenocrates is presented.

Multilingual Zambia - Language Issues In Primary/Secondary Schools Of The Eastern/Southern Provinces, Kenzie Steiner

NUTR/GLST 498b: Global Research Experiences in Nutrition and Health

Introduction: Zambia is a multilingual country that uses 8 different languages for instruction including English and 7 other indigenous languages.

Methods: Survey research conducted between May-June 2022 on 6-7th graders within 9 Zambian schools. Classroom observations made and teachers interviewed.

Results: In Eastern and Southern Provinces, Zambian teachers speak an average of 5 languages while students speak an average of 2. Both teachers and students say English remains the most important language followed by first languages.

Conclusion: Continued research on language-in-education policies and impacts on student performance must be conducted if “One Zambia, One Nation” is meant to promote all …

Biomarker Metabolite Discovery For Pancreatic Cancer Using Machine Learning, Immanuelle Kezia, Linda Erlina, Aryo Tedjo, Fadilah Fadilah

Indonesian Journal of Medical Chemistry and Bioinformatics

Pancreatic cancer is one of the deadliest cancers in the world. This cancer is caused by multiple factors and mostly detected at late stadium. Biomarker is a marker that can identify some diseases very specific. For pancreatic cancer, biomarker has been recognized using blood sample known as liquid biopsy, breath, pancreatic secret, and tumor marker CA19-9. Those biomarkers are invasive, so we want to identify the disease using a very convenient method. Metabolite is product from cell metabolism. Metabolites can become a biomarker especially from difficult diseases. In this paper, we want to find biomarker from metabolite using machine learning …

Pd-L1 + Macrophages Are Associated With Favorable Features In Primary Mediastinal (Thymic) Large B-Cell Lymphoma, Raphael E Steiner, Edwin R Parra, Francisco Vega, Lei Feng, Jason R Westin, Sattva S Neelapu, Paolo Strati, Michael R Green, Christopher R Flowers, Luisa M Solis, Ignacio I Wistuba, Sairah Ahmed, Ranjit Nair, Fredrick B Hagemeister, Mansoor Noorani, Mario L Marques-Piubelli

Faculty, Staff and Student Publications

Primary mediastinal (thymic) large B-cell lymphoma (PMBCL) is a rare, aggressive subtype of non-Hodgkin lymphoma and has a complex inflammatory microenvironment. Although most patients can be cured with standard-of-care immunochemotherapy, patients who have disease relapse have an unfavorable prognosis. Pre-treatment prognostic biomarkers in PMBCL are needed. In this retrospective study, we analyzed the clinical features and outcomes of PMBCL patients and their association with immune cell subpopulations identified by multiplex immunofluorescence at initial diagnosis. Two different antibody panels were used to assess macrophages in tissue biopsy specimens collected before the initiation of induction therapy. Twelve PMBCL patients, including five patients …

Multicenter Phase Ii Trial Of The Wee1 Inhibitor Adavosertib In Refractory Solid Tumors Harboring, Siqing Fu, Shuyang Yao, Yuan Yuan, Rebecca A Previs, Anthony D Elias, Richard D Carvajal, Thomas J George, Ying Yuan, Lihou Yu, Shannon N Westin, Yan Xing, Ecaterina E Dumbrava, Daniel D Karp, Sarina A Piha-Paul, Apostolia M Tsimberidou, Jordi Rodon Ahnert, Naoko Takebe, Karen Lu, Khandan Keyomarsi, Funda Meric-Bernstam

Faculty, Staff and Student Publications

PURPOSE: Preclinical cancer models harboring

PATIENTS AND METHODS: Patients aged ≥ 18 years with measurable disease and refractory solid tumors harboring

RESULTS: Thirty patients were enrolled. The median follow-up duration was 9.9 months. Eight patients had partial responses (PRs), and three had stable disease (SD) ≥ 6 months, with an ORR of 27% (95% CI, 12 to 46), a SD ≥ 6 months/PR rate of 37% (95% CI, 20 to 56), a median progression-free survival duration of 4.1 months (95% CI, 1.8 to 6.4), and a median overall survival duration of 9.9 months (95% CI, 4.8 to 15). Fourteen patients …

Dna Damage Response-Related Proteins Are Prognostic For Outcome In Both Adult And Pediatric Acute Myelogenous Leukemia Patients: Samples From Adults And From Children Enrolled In A Children's Oncology Group Study, Stefan E Hubner, Eduardo S De Camargo Magalhães, Fieke W Hoff, Brandon D Brown, Yihua Qiu, Terzah M Horton, Steven M Kornblau

Faculty, Staff and Student Publications

The survival of malignant leukemic cells is dependent on DNA damage repair (DDR) signaling. Reverse Phase Protein Array (RPPA) data sets were assembled using diagnostic samples from 810 adult and 500 pediatric acute myelogenous leukemia (AML) patients and were probed with 412 and 296 strictly validated antibodies, respectively, including those detecting the expression of proteins directly involved in DDR. Unbiased hierarchical clustering identified strong recurrent DDR protein expression patterns in both adult and pediatric AML. Globally, DDR expression was associated with gene mutational statuses and was prognostic for outcomes including overall survival (OS), relapse rate, and remission duration (RD). In …

A First-In-Human Phase I Study Of Milademetan, An Mdm2 Inhibitor, In Patients With Advanced Liposarcoma, Solid Tumors, Or Lymphomas, Mrinal M Gounder, Todd M Bauer, Gary K Schwartz, Amy M Weise, Patricia Lorusso, Prasanna Kumar, Ben Tao, Ying Hong, Parul Patel, Yasong Lu, Arnaud Lesegretain, Vijaya G Tirunagaru, Feng Xu, Robert C Doebele, David S Hong

Faculty, Staff and Student Publications

Purpose: This study evaluated the safety, pharmacokinetics, pharmacodynamics, and preliminary efficacy of milademetan, a small-molecule murine double minute-2 (MDM2) inhibitor, in patients with advanced cancers.

Patients and methods: In this first-in-human phase I study, patients with advanced solid tumors or lymphomas received milademetan orally once daily as extended/continuous (days 1-21 or 1-28 every 28 days) or intermittent (days 1-7, or days 1-3 and 15-17 every 28 days) schedules. The primary objective was to determine the recommended phase II dose and schedule. Secondary objectives included tumor response according to standard evaluation criteria. Predefined analyses by tumor type were performed. Safety and …

Accelerating Biosafety Capacity Building To Ensure National Biosecurity, Peipei Liu, Jiafu Jiang, Hao Lu, Peilei Cong, Lilin Zhao, Gexia Qiao, Dongsheng Zhou, Guizhen Wu

Bulletin of Chinese Academy of Sciences (Chinese Version)

Biosafety is an essential part of the national security system, which is related to people's lives and health, the country's longterm stability, and sustainable development, which is the bottom line that must be guaranteed. The international biosafety situation is grim and complex, while domestic biosafety faces challenges. Therefore, biosafety capacity building has become an international hot spot, among which scientific and technological innovation, talent training, and infrastructure platform construction are the top priorities. Although China has achieved strategic results in the rapid identification of pathogens, research, and development of specific vaccines and medicine in fighting against COVID-19 by relying on …

Strategies For Achieving Agriculture Carbon Peak And Carbon Neutrality In China Based On View Of Biogeochemical Cycle, Shiqi Yang, Xin Yan

Bulletin of Chinese Academy of Sciences (Chinese Version)

Biogeochemical cycle is the basic theory of matter (elements) flow among atmosphere, hydrosphere, biosphere and lithosphere, which provides important guidance to achieving the national goal of agriculture carbon peak (ACP) and agriculture carbon neutrality (ACN). As a basic industry, agriculture has large-scale temporal and spatial influence on the greenhouse effect, hence great importance should be attached to ACP and ACN in order to assist the overall strategy of achieving national carbon peak and neutrality. Based on the view of biogeochemical cycle and connotations of ACP and ACN, this article analyzes the paths to achieve ACP and ACN, and discusses the …

Thoughts And Suggestions On Oasis Ecological Construction And Agricultural Development In Hexi Corridor, Wenzhi Zhao, Heng Ren, Jun Du, Rong Yang, Qiyue Yang, Hu Liu

Bulletin of Chinese Academy of Sciences (Chinese Version)

Oasisization is an external manifestation of the temporal and spatial evolution of oasis in arid areas, and the regional water carrying capacity is the key to restricting oasis agriculture and ecological protection in arid areas. The Hexi Corridor is not only an important passage from the east to the west in China, but also an important carrier of regional development; it is not only an important ecological barrier in Northwest China, but also a typical irrigated agricultural area. After more than 60 years of construction, the Hexi Corridor has made remarkable achievements in social progress, traffic conditions, ecological construction and …

Enhancement Of Coastal Blue Carbon: Concepts, Techniques, And Future Suggestions, Guangxuan Han, Weimin Song, Yuan Li, Leilei Xiao, Mingliang Zhao, Xiaojing Chu, Baohua Xie

Bulletin of Chinese Academy of Sciences (Chinese Version)

The blue carbon function and carbon sequestration potential of coastal ecosystems, such as salt marshes, mangroves and seagrass beds, have emerged as one of the long-term solutions to mitigate global climate change. However, the blue carbon sequestration technology has been neglected in most ecological protection and restoration projects of coastal ecosystems. Besides, in the process of project implementation and management, the dynamic monitoring and systematic evaluation of carbon sink are imperfect. This study proposes the concept of enhancement of coastal blue carbon, focusing on four key technologies of soil carbon emission reduction technology, plant carbon sequestration technology, soil microbial carbon …

Status Quo Of Research And Suggestions On Reduction Of Non-Co2 Greenhouse Gas Emission From Chinese Farmland, Guangbin Zhang, Jing Ma, Hua Xu, Xiaoyuan Yan

Bulletin of Chinese Academy of Sciences (Chinese Version)

The mitigation of greenhouse gas (GHG) emissions is of great significance for controlling global warming. In 2014, the CH₄ and N₂O emissions from farmland accounted for 4.3% of the total GHG emissions in China. After the carbon peak target in 2030, fossil energy in China will be gradually replaced by clean energy, and then the contribution of CH₄ and N₂O emissions from farmland will be enlarged, leaving that the urgency and importance of emission reduction becomes increasingly prominent. However, available technologies of emission mitigation have not been fully adopted and promoted due to the …

Genetic Control Of Rna Editing In Neurodegenerative Disease, Sijia Wu, Qiuping Xue, Mengyuan Yang, Yanfei Wang, Pora Kim, Xiaobo Zhou, Liyu Huang

Faculty, Staff and Student Publications

A-to-I RNA editing diversifies human transcriptome to confer its functional effects on the downstream genes or regulations, potentially involving in neurodegenerative pathogenesis. Its variabilities are attributed to multiple regulators, including the key factor of genetic variants. To comprehensively investigate the potentials of neurodegenerative disease-susceptibility variants from the view of A-to-I RNA editing, we analyzed matched genetic and transcriptomic data of 1596 samples across nine brain tissues and whole blood from two large consortiums, Accelerating Medicines Partnership-Alzheimer's Disease and Parkinson's Progression Markers Initiative. The large-scale and genome-wide identification of 95 198 RNA editing quantitative trait loci revealed the preferred genetic effects …

Cognitive Sparing In Proton Versus Photon Radiotherapy For Pediatric Brain Tumor Is Associated With White Matter Integrity: An Exploratory Study, Lisa E Mash, Lisa S Kahalley, Kimberly P Raghubar, Naomi J Goodrich-Hunsaker, Tracy J Abildskov, Luz A De Leon, Marianne Macleod, Heather Stancel, Kelley Parsons, Brian Biekman, Nilesh K Desai, David R Grosshans, Arnold C Paulino, Zili D Chu, William E Whitehead, Mehmet Fatih Okcu, Murali Chintagumpala, Elisabeth A Wilde

Faculty, Staff and Student Publications

Radiotherapy for pediatric brain tumors is associated with reduced white matter structural integrity and neurocognitive decline. Superior cognitive outcomes have been reported following proton radiotherapy (PRT) compared to photon radiotherapy (XRT), presumably due to improved sparing of normal brain tissue. This exploratory study examined the relationship between white matter change and late cognitive effects in pediatric brain tumor survivors treated with XRT versus PRT. Pediatric brain tumor survivors treated with XRT (

Research Talks And What It Means To Be A Woman In Environmental Science, April Watson, Cassandra S. Korte, Deborah Williams, Marchéta Wright, Maria Gabriella Almeida

Women in Science Conference

Dr. April Watson, Archaeologist Everglades National Park
/="/">Dr. Cassandra Korte, Associate Professor, Scientific Literacy and Biology
/="/">Dr. Deborah Williams, Assistant Professor
/="/">Dr. Marcheta Wright, Professor, International Relations
/="/">Ms. Maria De Almeida, Lynn Graduate Student, M.S. Biological Sciences

2022-23 Women In Environmental Science Conference Schedule (Pdf), Lynn University

Women in Science Conference

No abstract provided.

The Effects Of Chronic Hypercarbia On Morphological And Ventilatory Development In Crayfish, Cassandra Poeppelman, Josh Hivner, Lynn K. Hartzler

Festival of Research

Instances of abnormally high CO2 levels are becoming increasingly common in freshwater ecosystems undergoing eutrophication. Chronic hypercarbia (long-term elevation of the partial pressure of carbon dioxide (Pco2)) is pervasive in these eutrophic ecosystems. Elevated Pco2 increases the ventilation and metabolism of some tadpoles and aquatic frogs and hinders their morphological development23. We expect that chronic hypercarbia will affect most aquatic organisms in the same way, but it remains to be verified that chronic hypercarbic conditions also alter aquatic organisms similarly to intermittent and acute hypercarbic challenges.

The Influence Of Als-Associated Matr3 Toxicity On Cell Size In The Yeast Model, Rahul Shah, Fawaz Ghouse, Widad El-Zein, Quan Zhong, Shulin Ju

Festival of Research

Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease1. The pathology of ALS is described as the progressive degeneration of motor neurons that initially leads to atrophy of the voluntary muscles followed by the involuntary muscles1,2. Ultimately, the cause of death is pulmonary distress due to loss of function of the diaphragm2. Life expectancy after diagnosis is usually one year, and there are currently no cures or effective treatments for this fatal disease3. Approximately 90% of all ALS cases are sporadic meaning that the disease is developed randomly, while around 10% of the cases are familial meaning that the disease …

Evaluation Of Peroxyacetic Acid, Liquid Buffered Vinegar, And Cultured Dextrose Fermentate As Potential Antimicrobial Interventions For Raw Chicken Livers, Leslie Pearl M. Cancio, Mary-Grace C. Danao, Gary Sullivan, Byron D. Chaves

Department of Nutrition and Health Sciences: Faculty Publications

This study aimed to evaluate the use of peroxyacetic acid (PAA), buffered vinegar (BV), and cultured dextrose fermentate (CDF) to reduce Salmonella on artificially inoculated raw chicken livers, one of the most consumed offal around the world. Samples were inoculated with a 5-strain cocktail of poultry-borne Salmonella to obtain 10⁶ CFU/g and immersed for 90 s with agitation in one of the following treatments: distilled water (control), 450 ppm PAA, 2.0% (w/v) BV, or 1.5% (w/v) CDF, prior to storing at 4^oC. Salmonella was enumerated on XLD agar and monitored for 14 days. Data were analyzed using …

Morphological Differences Align With Habitat Partitioning Among Three Species Of Percina (Percidae: Actinopterygii) In The Roanoke River, Virginia, Michael M. Calvert, Steven L. Powers

Southeastern Fishes Council Proceedings

The upper Roanoke River has three species of Percina (P. nevisense, Chainback Darter; P. roanoka, Roanoke Darter; and P. rex, Roanoke Logperch). Resource partitioning appears to be a key component of maintaining diverse fish assemblages with habitat and food partitioning cited as especially important in communities containing members of the same family. Some aspects of the diets of these species have been documented in the literature with only modest differences among them. Microhabitat data for adults of these species have also been published revealing differences in habitat occupied by each with P. roanoka living in the fastest, shallowest …

The Santa Clara, 2023-03-17, Santa Clara University

The Santa Clara

No abstract provided.

Identifying And Knocking Out Deep Brain Photoreceptors In The Larval Zebrafish Optic Tectum, Allison Pickens

Undergraduate Honors Theses

Deep brain photoreceptors (DBPs) are light sensing neurons present in mammals and non-mammalian vertebrates. In non-mammalian vertebrates, studies have shown DBP involvement in various time and light dependent behaviors including circadian rhythm, phototaxis, and seasonal reproduction. In adult teleosts, DBPs are present throughout the brain, including the optic tectum (OT), a multilaminated midbrain structure responsible for multisensory integration. While their approximate location in teleosts is known, little is known about DBP’s functionality. In this study, we focused on DBPs present in the larval zebrafish OT. Single-cell RNA sequencing of the larval zebrafish OT showed the presence of several opsins. We …

Global Scientific Trends On Healthy Eating From 2002 To 2021: A Bibliometric And Visualized Analysis, Te Fang, Hongyi Cao, Yue Wang, Yang Gong, Zhongqing Wang

Faculty, Staff and Student Publications

Diet has been recognized as a vital risk factor for non-communicable diseases (NCDs), climate changes, and increasing population, which has been reflected by a rapidly growing body of the literature related to healthy eating. To reveal a panorama of the topics related to healthy eating, this study aimed to characterize and visualize the knowledge structure, hotspots, and trends in this field over the past two decades through bibliometric analyses. Publications related to healthy eating between 1 January 2002 and 31 December 2021 were retrieved and extracted from the Web of Science database. The characteristics of articles including publication years, journals, …

Human Spacesuit Interaction During Eva Of The Legs Using A Force Sensing System, Niraliben D. Patel

USF Tampa Graduate Theses and Dissertations

Astronauts perform a multitude of tasks in space, both in the spacecraft and outside of the spacecraft. Extravehicular Activity (EVA) refers to any activity that is completed outside of the spacecraft, whether it is work on the actual spacecraft, spacewalks, or conducting sample collections on other planets and moons. To do this safely, a pressurized Extravehicular Mobility Unit (EMU) or commonly known as the spacesuit is used. There have been multiple iterations of the United States EMU with advances to further optimize the astronaut safety and EVA tasks. However, there is still relatively little information on the movement of the …

A Fog Computing Framework For Intrusion Detection Of Energy-Based Attacks On Uav-Assisted Smart Farming, Junaid Sajid, Kadhim Hayawi, Asad Waqar Malik, Zahid Anwar, Zouheir Trabelsi

All Works

Precision agriculture and smart farming have received significant attention due to the advancements made in remote sensing technology to support agricultural efficiency. In large-scale agriculture, the role of unmanned aerial vehicles (UAVs) has increased in remote monitoring and collecting farm data at regular intervals. However, due to an open environment, UAVs can be hacked to malfunction and report false data. Due to limited battery life and flight times requiring frequent recharging, a compromised UAV wastes precious energy when performing unnecessary functions. Furthermore, it impacts other UAVs competing for charging times at the station, thus disrupting the entire data collection mechanism. …

Effects Of The Ketogenic Diet On Spatial Memory And Long-Term Potentiation In The Ca1 Region Of The Hippocampus In Young Rodents, Jed Christensen

Undergraduate Honors Theses

The ketogenic diet (KD) originated as a treatment for epilepsy nearly a century ago, though its neurological effects are not completely understood. In recent years the diet has resurged as a weight loss aid, reinvigorating research investigating its effects on the nervous system. Notably, the KD alters the concentration of glucose and ketones in the brain, and recent research suggests that the elevated ketone concentration, in the form of beta-hydroxybutyrate, induced by the diet enhances recognition memory and mitochondrial efficiency in the hippocampus. To further explore the effects of the KD, we examined its cognitive effects on spatial memory and …

A Mast Cell-Thermoregulatory Neuron Circuit Axis Regulates Hypothermia In Anaphylaxis, Chunjing Bao, Ouyang Chen, Huaxin Sheng, Jeffrey Zhang, Yikai Luo, Byron W Hayes, Han Liang, Wolfgang Liedtke, Ru-Rong Ji, Soman N Abraham

Faculty, Staff and Student Publications

IgE-mediated anaphylaxis is an acute life-threatening systemic reaction to allergens, including certain foods and venoms. Anaphylaxis is triggered when blood-borne allergens activate IgE-bound perivascular mast cells (MCs) throughout the body, causing an extensive systemic release of MC mediators. Through precipitating vasodilatation and vascular leakage, these mediators are believed to trigger a sharp drop in blood pressure in humans and in core body temperature in animals. We report that the IgE/MC-mediated drop in body temperature in mice associated with anaphylaxis also requires the body's thermoregulatory neural circuit. This circuit is activated when granule-borne chymase from MCs is deposited on proximal TRPV1+ …

Protocols For Single-Cell Rna-Seq And Spatial Gene Expression Integration And Interactive Visualization, Surbhi Sona, Matthew Bradley, Angela H Ting

Faculty, Staff and Student Publications

There is a wealth of software that utilizes single-cell RNA-seq (scRNA-seq) data to deconvolve spatial transcriptomic spots, which currently are not yet at single-cell resolution. Here we provide protocols for implementing Seurat and Giotto packages to elucidate cell-type distribution in our example human ureter scRNA-seq dataset. We also describe how to create a stand-alone interactive web application using Seurat libraries to visualize and share our results. For complete details on the use and execution of this protocol, please refer to Fink et al. (2022).

Ferroptosis Hijacking By Mycobacterium Tuberculosis, Boyi Gan

Faculty, Staff and Student Publications

A recent study from Nature Communications reveals that Mycobacterium tuberculosis can hijack epigenetic machinery in host cells and induce host cell ferroptosis, which promotes pathogen pathogenicity and spread. These findings also suggest new therapeutic strategies to treat tuberculosis.

Apkcs Role In Neuroblastoma Cell Signaling Cascades And Implications Of Apkcs Inhibitors As Potential Therapeutics, Sloan Breedy

USF Tampa Graduate Theses and Dissertations

Neuroblastoma (NB) is a cancer that develops in the neuroblasts. It is the most common cancer in children under the age of 1 year, accounting for approximately 6% of all cancers. The prognosis of NB is linked to both age and degree of cell differentiation. This results in a range of survival rates for patients, with outcomes ranging from recurrence and mortality to high survival rates and tumor regression. Our previous work indicated that PKC-ι promotes cell proliferation in NB cells through the PKC-ι/Cdk7/Cdk2 cascade. We report on two atypical protein kinase inhibitors as potential therapeutic candidates against BE(2)-C and …