Life Sciences Commons^™

Behavioral And Neural Mechanisms Of Serotonin Modulation Of Impulsivity And Reward, Stephanie S. Desrochers

Dartmouth College Ph.D Dissertations

Despite its prevalence in many psychiatric disorders, such as attention deficit hyperactivity disorder, suicidal depression, schizophrenia, and aggression and motivational disorders, impulsivity and its biological bases remain poorly understood. Subdivisions of impulsivity, including impulsive action (reduced response inhibition) and impulsive choice (reduced delay of gratification), sometimes present in an uncorrelated manner. This complexity renders pathological impulsivity difficult to treat, as different underlying causes likely result in different phenotypic presentations, despite being placed under one umbrella term. In order to study the behavior and biology of one particular facet of impulsivity, this dissertation utilizes the serotonin 1B receptor (5-HT1BR; an inhibitory …

Understanding The Implications Of Lineage Plasticity In Breast Cancer Evolution And Chemotherapy Response, Gadisti Aisha Mohamed

Dartmouth College Ph.D Dissertations

Intra-tumoral heterogeneity and the presence of a phenotypically diverse cell population within a single tumor represents a major hurdle in the understanding of tumor progression and dynamics, and complicates the effective diagnosis and management of this disease. One of the ways by which tumors gain intra-tumoral variation is through the acquisition of phenotypic or lineage plasticity, whereby tumor cells evolve away from the lineage of origin and gain altered profiles. These alterations may impart specific survival benefits to different subpopulations of cells, enabling them to proliferate faster, migrate away from the site of the primary tumor or evade drug-induced elimination, …

Smokejumper Magazine, April 2023, National Smokejumper Association

Smokejumper and Static Line Magazines

This issue of the National Smokejumper Association (NSA) Static Line, contains the following articles: Message from the President; 1958: The Best Summer Ever Part 2: Tanoak and the Old Glory Fire; Defending the Tribe; Landowners File Suits Against USFS—Chetco Bar Fire Oregon; Recollections of My Rookie Year; Cinnamon Marked the Time; History Preservation..............................................17 Too Steep/Too Roughy—A New Book....................19 Odds and Ends; Input from Jumper Who Lives Outside the City; Moose Creek 1959 "Let's Not Forget; Save Our National Forests with Shaded Fuel Breaks; Touching All Bases; The Rescue Jump for "Animal" Ed Weissenback; Catastrophic Fire Awareness, Prevention, Response, Suppression and …

Jewish Genetic Diseases: Knowledge Of Reproductive Risk And Cancer Predisposition Among Young Adults Of Ashkenazi Descent, Hayley Kathleen Granger

Theses and Dissertations

Founder mutations within the Ashkenazi Jewish (AJ) population are associated with significantly higher carrier rates for certain severe, life-limiting conditions collectively called Jewish Genetic Diseases (JGDs), and for pathogenic variants in the BRCA1 and BRCA2 (BRCA1/2) cancer susceptibility genes. Efforts to educate AJ individuals about the implications of these founder mutations and available testing have increased the past forty years; however, studies suggest AJ individuals are not well educated on the topic (Hardy et al., 2022; Kaback, 2001; Warsch et al., 2014). Studies evaluating the reason for this gap in knowledge of young AJ adults are lacking. This study aimed …

Assessing The Gaps And Potential Solutions To Improve Access To Genetic Testing For Autistic Individuals, Nisha Dhiren Pandya

Theses and Dissertations

The prevalence of Autism Spectrum Disorder (ASD) continues to increase. Numerous genetic syndromes increase the risk of ASD. Professional organizations have published guidelines on the genetic testing recommended for Autistic individuals. However, healthcare providers do not unanimously offer genetic testing or refer for a genetics evaluation. Notably, parents of Autistic individuals express interest in learning about genetic testing as an option for their children.

This study aimed to identify gaps to improve access to genetic evaluations for Autistic individuals and their families. A survey was sent to healthcare providers across the United States that currently see Autistic individuals. We expected …

An Examination Of Inter-Limb Functional Asymmetry After A Fatiguing Bout Of Exercise In High Level Soccer Players, Nestor Urrea

Theses and Dissertations

INTRODUCTION: Inter-limb functional asymmetries greater than 15% have been linked to a greater incidence of injury. Moreover, asymmetries greater than 10% have shown greater risk of injury and worsened sport performance, especially for strength and power capabilities, in athletes of multiple sports. Fatigue and sex are factors that seem to influence injury rates as well as greater asymmetries between limbs. This research project aims to investigate the effects of a fatiguing bout of exercise in strength and power inter-limb functional asymmetries in male and female soccer players. It was hypothesized that strength and power asymmetries are negatively affected after a …

Consultation For Proposed 2023/24 Declared Pest Rates Statistical Summary - 14 April To 15 May 2023, Department Of Primary Industries And Regional Development, Western Australia

Biosecurity published reports

Before determining a rate, the Minister for Agriculture and Food is required to consult with owners of the land to be rated, as described in the Biosecurity and Agriculture Management (Declared Pest Account) Regulations 2014 (the Regulations).

The annual process for consultation enables the Department of Primary Industries and Regional Development (DPIRD) to gauge landholder perception on the Declared Pest Rate (DPR). This information is used to inform decisions regarding the DPR and associated biosecurity objectives.

The Effect Of A Pharmaceutical Ghrelin Agonist On Lifespan In C57bl/6j Male Mice: A Controlled Experiment, Kathryn A Kaiser, Inga Kadish, Thomas Van Groen, Daniel L Smith, Stephanie Dickinson, Beate Henschel, Erik S Parker, Andrew W Brown, David B Allison

Children’s Nutrition Research Center Staff Publications

Interventions for animal lifespan extension like caloric restriction (CR) have identified physiologic and biochemical pathways related to hunger and energy-sensing status as possible contributors, but mechanisms have not been fully elucidated. Prior studies using ghrelin agonists show greater food intake but no effect on lifespan in rodent models. This experiment in male C57BL/6J mice tested the influence of ghrelin agonism for perceived hunger, in the absence of CR, on longevity. Mice aged 4 weeks were allowed to acclimate for 2 weeks prior to being assigned (N = 60/group). Prior to lights off daily (12:12 cycle), animals were fed a ghrelin …

Fisheries Science Update - Gascoyne Demersal Scalefish Resource - April 2023, Department Of Primary Industries And Regional Development, Western Australia

Fisheries Science Updates

Key points: 2022 stock assessment outcomes:

• The Gascoyne Demersal Scalefish Resource (GDSR) comprises more than 60 species inhabiting Gascoyne oceanic waters (excluding inner Shark Bay), with pink snapper and goldband snapper recognised as the two indicator species.
• Oceanic pink snapper is five years into a 20-year recovery plan following a 2017 stock assessment that showed the stock was at severe risk.
• The GDSR oceanic pink snapper recovery plan is based on limiting the annual total fishing mortality of oceanic pink snapper to 100 tonnes (all sectors combined) and providing targeted protection for key spawning aggregations.
• The Department of Primary Industries …

Toward The Yeast Surface Display Of Microviridin B, Jillian Leigh Stafford

Chemistry and Chemical Biology ETDs

Humans have turned to natural products for medicinal therapeutics for millennia. In recent years, the ribosomally synthesized and post-translationally modified peptide (RiPP) class of natural products have garnered a lot of attention due to their ability for heterologous expression, relative ease of mutation, and vast biological activates. Microviridins are a family of RiPPs that contain a tricyclic cage-like structure through the formation of two lactone rings and one lactam ring catalyzed by two ATP-grasp ligase family enzymes. Microviridins are potent inhibitors of serine proteases and mutational studies of a small number of residues indicates the potential of peptide engineering protease …

Aloe Barbadensis Rinds Employ Physical And Chemical Defense Mechanisms Against Insect Herbivores With Varying Success, Zachary Johnson, Ishveen Kaur, Fernando Castillo, Rupesh R. Kariyat, Debasish Bandyopadhyay

School of Integrative Biological & Chemical Sciences Faculty Publications

Plants deter herbivory through a suite of physical and chemical defenses. While most studies have focused on understanding one or the other, efficient plant defense against herbivory is often cumulative. To examine this, we used Aloe barbadensis (Asphodelaceae) as a model, since in natural settings, the species is found to be well-defended against insect herbivores. To start with, we hypothesized that the epicuticular wax potentially plays an important role in herbivore defense as the major physical defense. To test our hypothesis, we conducted bioactivity-guided extraction and polarity-based fractionation of A. barbadensis rinds. We then mixed them into an artificial diet, …

Directory Of Landscape Professionals Trained In Ecological Landscaping For Water Quality Protection The Individuals And Businesses Listed Have Completed Unh Cooperative Extension Training Programs For Professionals As Indicated, And Have Agreed To Be Listed In The Directory. Individuals Looking For Related Products Or Services Are Encouraged To Contact One Or More Of The Professionals Listed In Your Area. Updated 2023, Michelle Lemos

Advisory Council

No abstract provided.

Neurogenetic Function Of Host Cell Factor-1, Victoria Lynn Castro

Open Access Theses & Dissertations

Neural precursor cells (NPCs) are the stem-like cells of the developing brain. These cells differentiate into the differentiated cell types of the central nervous system. If disruption occurs in the number of total NPCs formed or their survival, various disorders including learning disabilities, behavioral problems, or epilepsy can occur. This dissertation describes how the HCFC1 gene controls the proliferation and differentiation of NPCs. HCFC1 encodes for a transcriptional co-factor that regulates the growth and metabolism of stem cells, including NPCs. Mutations in HCFC1 cause cblX syndrome, a neural developmental disorder that affects the nervous system and causes microcephaly, epilepsy, and …

Comparing Efficiency, Empowerment, And Satisfaction Between Individual And Group Genetic Counseling For Prostate Cancer, Sarah Marie Dickman

Theses and Dissertations

A hereditary cause for prostate cancer can be identified in 5-17% of cases, which can impact treatment and cancer screening recommendations for patients and their families. Increased demand for genetic testing has necessitated consideration of alternative genetic counseling service delivery models to meet needs. Studies have shown that group genetic counseling increases efficiency while maintaining the same patient benefits as individual genetic counseling, but research has mainly focused on patients who were assigned female at birth (AFAB). The purpose of this study was to evaluate the utility of group genetic counseling for prostate cancer by assessing participants’ satisfaction and feelings …

Genetic Testing For Autism: The Autistic Adult Perspective, Thomas Scott Dent

Theses and Dissertations

Many professional medical organizations recommend some level of genetic testing as standard of care for those diagnosed with autism spectrum disorder. However, genetic testing related to the diagnosis of autism is seen as controversial by many in the autistic community. While opinions about genetic testing have been well-documented from the perspective of the parents of autistic children, our understanding of the autistic adult perspective remains limited. We implemented a descriptive, web-based survey of autistic adults to assess their awareness of, attitudes towards, and interests in genetic testing for autism (n = 145). Our data demonstrated that half of our participants …

Evaluating Health Awareness In Cancer Genetics Amongst The Black And African American Community In South Carolina, Annika Jaliya Gadson

Theses and Dissertations

Historically minoritized individuals are underrepresented in genomic research which limits the ability to fully understand genetic variation within the population (Sirugo et al., 2019). This creates bias that questions the effectiveness of guidelines for genetic testing, predictive risk values, and medical management. Disparities in cancer genetics may be attributed to historical events that have cultivated mistrust in research and medicine, institutional bias, provider skepticism in patient reporting of medical symptoms, and limited access to genetic testing (Saulsberry et al., 2013). More exploration is needed to better understand how to increase access and awareness of cancer genetic services to Black and …

Genomic Analysis Of Exophiala Sp. Etnp2018, A Marine Fungal Strain Isolated From An Oxygen Minimum Zone, Margaret Kelly Bernish

Theses and Dissertations

Microbial metabolic activity is central to biogeochemical cycling in virtually all ecosystems. Fungi are important parts of microbial communities, serving as decomposers, parasites, and symbionts. Most of our understanding of fungal ecology is derived from the study of isolated, cultured terrestrial fungi. However, the marine environment includes thousands of divergent, uncultured fungi. A number of these species, which include saprobes, parasites, and endophytes, can survive and sporulate in a wide range of salinities. Other such species face the additional challenge of limited nutrient accessibility. The genus Exophiala includes agents of mycoses in both humans and in marine animals. This research …

Exercise And Mental Health Over The Course Of A Semester, Jamie Alexis Whitney

Theses and Dissertations

Introduction and purpose: Anxiety and depression are two of the most common mental health struggles in the United States each year. There has been promising research noting the positive effects of exercise on lowering symptoms of both anxiety and depression. Anxiety and depression are highly prevalent on college campuses, especially during high stress portions of the semester. The purpose of this study was to observe the changes in mental health over the course of the semester and if exercise level mediated any of these changes in the university population. Methods: Participants scanned a QR code or followed a link to …

Genetic Mechanisms Underlying Maladaptation In Specialized Species Interactions, Nitin Ravikanthachari

Theses and Dissertations

Adaptation has been used as the framework to understand the power of natural selection in structuring biodiversity and driving biological interactions. However, recent examples have indicated that many organisms are maladapted to their local conditions. Maladaptation can result from various causes including rapid environmental change, novel environments, interplay of evolutionary forces (viz: gene flow-selection balance) and anthropogenic disturbance.

To dissect the genetic mechanisms underlying maladaptation, I used the interaction between Pieris macdunnoughii (Remington) (Lepidoptera: Pieridae) which lays eggs on an invasive mustard Thlaspi arvense (L.) (Brassicaceae), which is lethal to the larvae.

First, local adaptation to avoid laying eggs on …

Parent Perspectives On Barriers And Facilitators To Optimal Healthcare And Medical Screenings For Children With Down Syndrome In South Carolina, Vinita Oberoi Leedom

Theses and Dissertations

Children with Down syndrome (DS) often have co-occurring conditions affecting vision, hearing, sleeping, and more. Screenings, as recommended by the American Academy of Pediatrics (AAP), can help prevent secondary disability, and allow children to thrive. Studies have evaluated the receipt of recommended screenings, but barriers and facilitators surrounding access to screenings and care have not been described.

Parents of 24 children with DS in SC were recruited through schools and family support groups. One-hour long interviews were conducted in English and Spanish. Information was collected on health, healthcare quality, respiratory concerns, pandemic effects, access to care, and knowledge about AAP …

A Randomized, Placebo Controlled, Double-Blind, Crossover Study To Evaluate The Effects Of Two Novel Hydration Beverage Formulas On Rehydration In Healthy Adults, Nathaniel David Rhoades

Theses and Dissertations

Intro: Dehydration is common in athletes and can lead to reductions in cognitive and physical performance. While there are many commercially available hydration beverages, most contain high amounts of CHO and are marketed as functional beverages. The purpose of this study was to determine the effects of two novel hydration beverage formulas (HMAA, HM) on hydration, cognitive performance, and time to exhaustion (TTE). Methods: Sixteen subjects (n=8 women, n=8 men) completed three experimental days where they consumed one of three conditions (HMAA, HM, or placebo) assigned randomly. The experimental protocol was completed in a heat chamber at 30-32℃ and 45-50% …

Customer Discovery And Applied Research And Development For An Environmental Nanotechnology, Paul Michael Vecchiarelli

Theses and Dissertations

Technology transfer is a process by which an innovative technology, typically produced in a non-commercial setting such as academia, is developed into a potential market opportunity. The first phase of technology transfer, once a technology has been developed, is to identify a customer segment and determine a value proposition that describes what need the technology will fulfill for them. This phase has been systematized into a framework known as customer discovery. Success in customer discovery will indicate technological gaps, such as scale-up, prototyping, and realistic testing, that are needed to deliver the value proposition to the initial customer. Both phases …

Comparative- And Network-Based Proteomic Analysis Of Bacterial Chondronecrosis With Osteomyelitis Lesions In Broiler's Proximal Tibiae Identifies New Molecular Signatures Of Lameness, Jennifer Cook, Elizabeth Greene, Alison Ramser, Garrett J. Mullenix, Jalila S. Dridi, Rohana Liyanage, Robert F. Wideman Jr., Sami Dridi

Poultry Science Faculty Publications and Presentations

Bacterial Chondronecrosis with Osteomyelitis (BCO) is a specific cause of lameness in commercial fast-growing broiler (meat-type) chickens and represents significant economic, health, and wellbeing burdens. However, the molecular mechanisms underlying the pathogenesis remain poorly understood. This study represents the first comprehensive characterization of the proximal tibia proteome from healthy and BCO chickens. Among a total of 547 proteins identified, 222 were differentially expressed (DE) with 158 up- and 64 down-regulated proteins in tibia of BCO vs. normal chickens. Biological function analysis using Ingenuity Pathways showed that the DE proteins were associated with a variety of diseases including cell death, organismal …

Dietary Soy Galactooligosaccharides Affect The Performance, Intestinal Function, And Gut Microbiota Composition Of Growing Chicks, K. D. Teague, G. Tellez-Isaias, Jianmin Chai, V. Petrone-Garcia, C. N. Vuong, A. Blanch, S. H. Rasmussen, K. Brown, Jiangchao Zhao, S. J. Rochell

Poultry Science Faculty Publications and Presentations

The objective of this experiment was to investigate the effects of the dietary soy galactooligosaccharides (GOS), raffinose and stachyose, on performance, gastrointestinal health, and systemic stress in young broilers. Birds were fed a GOS-devoid diet based on soy protein isolate (SPI) or the SPI diet with 0.9, 1.8, 2.7, or 3.6% added stachyose and raffinose in a ratio of 4:1 at the expense of corn starch. These 5 treatments were administered to 10 replicate cages of 8 birds. Performance was measured weekly and excreta moisture, N retention, apparent metabolizeable energy, and complete blood cell counts were …

The Photochemical Evolution Of Polycyclic Aromatic Hydrocarbons And Nontronite Clay On Early Earth And Mars, Nina Kopacz, Maria Angela Corazzi, Giovanni Poggiali, Ayla Von Essen, Vincent Kofman, Teresa Fornaro, Hugo Van Ingen, Eloi Camprubi, Helen E. King, John Brucato, Inge Loes Ten Kate

School of Integrative Biological & Chemical Sciences (Formerly Dept. of Biology)

The photochemical evolution of polycyclic aromatic hydrocarbons (PAHs), an abundant form of meteoritic organic carbon, is of great interest to early Earth and Mars origin-of-life studies and current organic molecule detection efforts on Mars. Fe-rich clay environments were abundant on early Earth and Mars, and may have played a role in prebiotic chemistry, catalyzing the breakdown of PAHs and freeing up carbon for subsequent chemical complexification. Current Mars is abundant in clay-rich environments, which are most promising for harboring organic molecules and have comprised the main studied features by the Curiosity rover in search of them. In this work …

3rd Place Contest Entry: Using The Scientific Method To Combat The Biological And Sociological Effects Of The Covid-19 Pandemic: An Aspiring Healthcare Professional’S Perspective, Isabelle Dhindsa

Kevin and Tam Ross Undergraduate Research Prize

This is Isabelle Dhindsa's submission for the 2023 Kevin and Tam Ross Undergraduate Research Prize, which won third place. It contains their essay on using library resources, their bibliography, and a sample of their research project on using the scientific method to combat the biological and sociological effects of the COVID-19 pandemic.

Isabelle is a fourth-year student at Chapman University, majoring in Biology. Their faculty mentor is Dr. Carmichael Peters.

Co-Alteration Network Architecture Of Major Depressive Disorder: A Multi-Modal Neuroimaging Assessment Of Large-Scale Disease Effects, Jodie P. Gray, Jordi Manuello, Aaron F. Alexander-Bloch, Cassandra Leonardo, Crystal Franklin, Sueng Choi, Franco Cauda, Tommaso Costa, John Blangero, David C. Glahn, Peter T. Fox

School of Medicine Publications

Major depressive disorder (MDD) exhibits diverse symptomology and neuroimaging studies report widespread disruption of key brain areas. Numerous theories underpinning the network degeneration hypothesis (NDH) posit that neuropsychiatric diseases selectively target brain areas via meaningful network mechanisms rather than as indistinct disease effects. The present study tests the hypothesis that MDD is a network-based disorder, both structurally and functionally. Coordinate-based meta-analysis and Activation Likelihood Estimation (CBMA-ALE) were used to assess the convergence of findings from 92 previously published studies in depression. An extension of CBMA-ALE was then used to generate a node-and-edge network model representing the co-alteration of brain areas …

Ranunculus Cut Flower Production In Utah, Shannon Rauter, Melanie Stock

All Current Publications

Ranunculus (Ranunculus asiaticus) is grown as a cool-season annual for cut flower production in Utah. Tuberous roots can be planted as early as November in a high tunnel for blooms beginning in April. For field production, plant in November with insulation or as early as possible in spring for blooms beginning in May. Flower production ceases when temperatures reach approximately 80°F, usually by early July in northern Utah. In North Logan, UT, high tunnels produced an average of 3 to 7 marketable stems per plant, compared to 1 to 2 stems per plant in the field. Profit potential …

Long-Term Outcomes Of Allogeneic Hematopoietic Cell Transplantation In Patients With Newly Diagnosed Multiple Myeloma, Aimaz Afrough, Leonard C Alsfeld, Denái R Milton, Ruby Delgado, Uday R Popat, Partow Kebriaei, Neeraj Saini, Samer Srour, Chitra Hosing, Faisal H Cheema, Sairah Ahmed, Elisabet E Manasanch, Hans C Lee, Gregory P Kaufman, Krina K Patel, Donna M Weber, Robert Z Orlowski, Chelsea C Pinnix, Bouthaina S Dabaja, Sheeba K Thomas, Richard E Champlin, Elizabeth J Shpall, Muzaffar H Qazilbash, Qaiser Bashir

Faculty, Staff and Student Publications

Despite remarkable progress in survival with the availability of novel agents, an overwhelming majority of patients with multiple myeloma (MM) have disease that relapses. Allogeneic (allo-) hematopoietic cell transplantation (HCT) is a potentially curative option for a subgroup of patients with high-risk MM. This study assessed the long-term outcome of MM patients who underwent allo-HCT while in first remission as consolidation treatment. Thirty-three patients with newly diagnosed MM who underwent allo-HCT as part of consolidation therapy between 1994 and 2016 were reviewed retrospectively. Of these patients, 70% underwent autologous HCT before allo-HCT. All patients were chemosensitive and achieved at least …

Five-Year Survivors From Brain Metastases Treated With Stereotactic Radiosurgery: Biology, Improving Treatments, Or Just Plain Luck?, Jane B Pearce, Fang-Chi Hsu, Claire M Lanier, Christina K Cramer, Jimmy Ruiz, Fei Xing, Wencheng Li, Christopher Whitlow, Jaclyn J White, Stephen B Tatter, Adrian W Laxton, Michael D Chan

Faculty, Staff and Student Publications

BACKGROUND: Improvements in therapies have led to an increasing number of long-term survivors of brain metastases. The present series compares a population of 5-year survivors of brain metastases to a generalized brain metastases population to assess for factors attributable to long-term survival.

METHODS: A single institution retrospective review was performed to identify 5-year survivors of brain metastases who received stereotactic radiosurgery (SRS). A historical control population of 737 patients with brain metastases was used to assess similarities and differences between the long-term survivor population and the general population treated with SRS.

RESULTS: A total of 98 patients with brain metastases …