Life Sciences Commons^™

Novel Allosteric Effectors Targeting Human Transcription Factor Tead, Mayar Terek Ibrahim, Gennady M. Verkhivker, Jyoti Misra, Peng Tao

Mathematics, Physics, and Computer Science Faculty Articles and Research

The Hippo pathway is an evolutionary conserved signaling network involved in several cellular regulatory processes. Dephosphorylation and overexpression of Yes-associated proteins (YAPs) in the Hippo-off state are common in several types of solid tumors. YAP overexpression results in its nuclear translocation and interaction with transcriptional enhanced associate domain 1-4 (TEAD1-4) transcription factors. Covalent and non-covalent inhibitors have been developed to target several interaction sites between TEAD and YAP. The most targeted and effective site for these developed inhibitors is the palmitate-binding pocket in the TEAD1-4 proteins. Screening of a DNA-encoded library against the TEAD central pocket was performed experimentally to …

Deepmicetl: A Deep Transfer Learning Based Prediction Of Mice Cardiac Conduction Diseases Using Early Electrocardiograms, Ying Liao, Yisha Xiang, Mingjie Zheng, Jun Wang

Faculty, Staff and Student Publications

Cardiac conduction disease is a major cause of morbidity and mortality worldwide. There is considerable clinical significance and an emerging need of early detection of these diseases for preventive treatment success before more severe arrhythmias occur. However, developing such early screening tools is challenging due to the lack of early electrocardiograms (ECGs) before symptoms occur in patients. Mouse models are widely used in cardiac arrhythmia research. The goal of this paper is to develop deep learning models to predict cardiac conduction diseases in mice using their early ECGs. We hypothesize that mutant mice present subtle abnormalities in their early ECGs …

Disentangling Sentience From Developmental Plasticity, Jonathan Birch

Animal Sentience

Plants, like animals, display remarkable developmental plasticity, inviting the metaphorical use of terms like “decision” and “choice”. In the animal case, this is not taken to be evidence of sentience, because sentience is a complex product of development, not something that guides it. We should apply the same standards when evaluating the evidence in plants. It is hard to overstate the contrast with the case of invertebrates such as octopuses, where pain markers that were originally developed for use in mammals have been clearly demonstrated and plausible neural substrates for sentience have been identified.

Shared Decision Making In Acute Pain Management In Patients With Opioid Use Disorder: A Scoping Review, Peter D Vu, Aila Malik, A Sarah Cohen, Vishal Bansal, Morgan R Cowan, Gregory M Blazek, Tiffany Champagne-Langabeer

Faculty, Staff and Student Publications

The treatment of acute pain over the years has changed with increasing alternative therapies and increased scrutiny of opioid prescriptions. Shared Decision Making (SDM) has become a vital tool in increasing patient engagement and satisfaction in treatment decisions. SDM has been successfully implemented in the management of pain in a variety of settings; however, information regarding the use of SDM for treating acute pain in patients with a history of opioid use disorder (OUD) remains scarce. Following the Preferred Reporting Items for Systematic Reviews and Meta-analysis Extension for Scoping Reviews (PRISMA-ScR), we conducted a review to understand how SDM is …

An Ode Model For Investigating The Sleep-Pain Relationship In Sickle Cell Disease, Quindel Jones, Angela M. Reynolds, Cecelia Valrie, Reginald Mcgee, Rebecca Segal

Biology and Medicine Through Mathematics Conference

No abstract provided.

Understanding Neutrophil Dynamics During Covid-19 Infection, Quiyana M. Murphy

Biology and Medicine Through Mathematics Conference

No abstract provided.

Mathematical Modeling Of Immune Response To Sars-Cov-2, Hwayeon Ryu

Biology and Medicine Through Mathematics Conference

No abstract provided.

Stochastic Gradient Descent Method For A Parameter Identification Problem In Elasticity Imaging, Basca Jadamba

Biology and Medicine Through Mathematics Conference

No abstract provided.

Appearance Of Multistability And Hydra Effect In A Discrete-Time Epidemic Model With Ricker Growth, Laura F. Strube, Shoshana Elgart, Lauren Childs

Biology and Medicine Through Mathematics Conference

No abstract provided.

The Mandelbrot Set For Networks, Templates And Mutated Systems, Anca R. Radulescu

Biology and Medicine Through Mathematics Conference

No abstract provided.

Evaluating A Temperature-Dependent Mosquito Population Model, Morgan H. Jackson, Elizabet Estallo, Cheng Ly, Michael Robert

Biology and Medicine Through Mathematics Conference

No abstract provided.

Intermittent Synchronization In Gamma-Band Neural Oscillations, Anh Nguyen, Leonid L. Rubchinsky

Biology and Medicine Through Mathematics Conference

No abstract provided.

Coffee Break, Coffee

Biology and Medicine Through Mathematics Conference

No abstract provided.

Modelling The Ability Of Mass Drug Administration To Interrupt Soil-Transmitted Helminth Transmission: Community-Based Deworming In Kenya As A Case Study, Stacey Smith?

Biology and Medicine Through Mathematics Conference

No abstract provided.

Overexpressing Two Helicobacter Pylori Small Rnas From A Bacterial Pathogenicity-Related Chromosomal Region To Investigate Their Regulation Of Virulence Genes, Roxanne N. Mcpeck, Olivia F. Morgan, Andrea R. Castillo Phd

2023 Symposium

The bacterial pathogen Helicobacter pylori infects the stomachs of approximately 50% of humanity, causing symptomatic disease (e.g., stomach ulcers, gastric cancer, and MALT lymphoma) in 10-15% of the infected. Colonizing the acidic, inhospitable stomach requires H. pylori to tightly regulate gene expression despite lacking many common bacterial genetic regulatory elements. The pathogen may compensate by using abundant non-protein-coding small RNAs (sRNAs) to regulate gene expression, including of infection-intensifying virulence genes. Additionally, severe disease and cancer correlate with infection by H. pylori strains that contain a nonessential chromosomal region, the cytotoxin-associated gene pathogenicity island (cagPAI). This encodes powerful virulence …

Lunch Provided, Lunch

Biology and Medicine Through Mathematics Conference

No abstract provided.

Analytical Approach For Monitoring The Behavior Of Patients With Pancreatic Adenocarcinoma At Different Stages As A Function Of Time, Aditya Chakaborty Dr, Chris P. Tsokos Dr

Biology and Medicine Through Mathematics Conference

No abstract provided.

A Novel Family Of Chain Binomial Models To Investigate Correlated Vaccination And Infection Rates In Sveirs Epidemic Dynamics, Divine Wanduku

Biology and Medicine Through Mathematics Conference

No abstract provided.

Studying The Effect Of Western Diet On Atherosclerosis Risk Factors, Eric L. Scott

Biology and Medicine Through Mathematics Conference

No abstract provided.

Effect Of Static Stretching On Agonists, Antagonists, And Agonist-Antagonist Combination On Total Training Volume, Diego Pessoa, Henrique Penfold, Sincler Pegado, Michel Gonçalves, Juliana Brandão Pinto De Castro, Jeffrey Willardson, Humberto Miranda

International Journal of Exercise Science

International Journal of Exercise Science 16(4): 665-675, 2023. The purpose of this study was to examine the effects of static stretching (SS) of agonists and antagonists between sets on the total training volume (TTV) performed across multiple sets for the leg extension exercise. Twelve male subjects with experience in resistance training (RT) participated in this study. Subjects performed 10 repetition maximum (10RM) test and retest trials for the leg extension exercise. Four different protocols were randomly applied as follows: quadriceps stretching (AG); hamstrings stretching (AN); quadriceps and hamstrings stretching (AGN); and traditional control without stretching (TR). Significant differences (p≤0.05) were …

Cardiovascular Responses During Light-Intensity Aerobic Exercise With Varying Levels Of Limb Occlusion Pressures., William R. Vanwye, Alyssa M. Weatherholt, Lee J. Winchester, Johnny G. Owens, Micah Spears

International Journal of Exercise Science

International Journal of Exercise Science 16(2): 676-687, 2023. The study aimed to assess cardiovascular responses to low-intensity aerobic exercise with varying levels of limb occlusion pressures (LOP) in a healthy population of men and women 30 to 60 years. The study was a single-session repeated measures design. Thirty individuals completed the study. All subjects participated in a single bout of low-intensity cycling (30-39% HRR) with bilateral lower extremity (LE) BFR for four 5-minute stages [0% (No BFR), 40%, 60%, and 80% LOP] with a 2-minute active rest between stages (BFR pressure released). The subjects’ systolic blood pressure (SBP), diastolic blood …

Modeling The Immune Response To Immunotherapy And Triple Negative Breast Cancer In Mice, Dayton J. Syme, Angelica Davenport, Yun Lu, Anna G. Sorace, Nicholas G. Cogan

Biology and Medicine Through Mathematics Conference

No abstract provided.

Parameter Estimation For Covid-19 Svird Model Using Predictor-Corrector Algorithm, Alejandra D. Herrera Reyes, Susan Rogowski, Diana White, Alexandra B. Smirnova, Ruiyan Luo, Yena Kim

Biology and Medicine Through Mathematics Conference

No abstract provided.

Coffee Break And Breakout Discussions, Coffee

Biology and Medicine Through Mathematics Conference

No abstract provided.

Modeling Hiv With Partnership Models, Kathleen Hoffman

Biology and Medicine Through Mathematics Conference

No abstract provided.

Vitreoscilla Globin Promoter Cloning And Testing In Escherichia Coli, Lauren J. Coffey

Rose-Hulman Undergraduate Research Publications

No abstract provided.

Influenza C And D Viruses Demonstrated A Differential Respiratory Tissue Tropism In A Comparative Pathogenesis Study In Guinea Pigs, Chithra C. Sreenivasan, Runxia Liu, Rongyuan Gao, Yicheng Guo, Ben M. Hause, Milton Thomas, Ahsan Naveed, Travis Clement, Dana Rausch, Jane Christopher-Hennings, Eric Nelson, Julian Druce, Miaoyun Zhao, Radhey S. Kaushik, Qingsheng Li, Zizhang Sheng, Dan Dan, Feng Li

Nebraska Center for Virology: Faculty Publications

Influenza C virus (ICV) is increasingly associated with community-acquired pneumonia (CAP) in children and its disease severity is worse than the influenza B virus, but similar to influenza A virus associated CAP. Despite the ubiquitous infection landscape of ICV in humans, little is known about its replication and pathobiology in animals. The goal of this study was to understand the replication kinetics, tissue tropism, and pathogenesis of human ICV (huICV) in comparison to the swine influenza D virus (swIDV) in guinea pigs. Intranasal inoculation of both viruses did not cause clinical signs, however, the infected animals shed virus in nasal …

Using Critical Incident Debriefing After Code Blue Events To Support Registered Nurses, David L. Boyd

Doctor of Nursing Practice (DNP) Projects

Using Critical Incident Debriefing after Code Blue Events to Support Registered Nurses

Section I: Abstract

Background: During a code blue event (CBE), the environment becomes highly stressful and intense. Nurses rapidly transition from performing life-saving procedures on their patients to carrying out their usual duties. Without proper debriefing, nurses cannot properly process their emotions leading to increased burnout and secondary traumatic stress (Stamm, 2010).

Local Problem: In 2021, the nurses at Providence Saint John’s Health Center (2021a) responded to 110 CBEs, a 43% increase from 2020. Without a process for critical incident debriefing (CID), these nurses were exposed to trauma …

A Taxonomic List Of The Old World Genera In The Subfamily Hesperiinae (Hesperiidae) Arranged Into Tribes, Jing Zhang, Qian Cong, Jinhui Shen, Leina Song, Nick V. Grishin

The Taxonomic Report of the International Lepidoptera Survey

A taxonomic list of valid genera in the subfamily Hesperiinae from the Old World assigned to tribes is provided. This list is based on phylogenetic analysis of genomic sequence data complemented by morphological considerations. As a result, there are no incertae sedis non-fossil genera in the family Hesperiidae.

Cover Crop Application On Dredged Sediments Increases Corn Yield Through Microorganism-Associated Enzyme-Driven Nutrient Mineralization, Ashley N. Julian, Louise M. Stevenson, Megan A. Rúa

Biological Sciences Faculty Publications

Background & Aims

Common strategies to mitigate soil degradation of agricultural soils include cover crop application and soil amendment addition. Applying dredged sediments as a soil amendment is gaining popularity since they often provide benefits other amendments lack; however, their use with cover crops is largely unexplored. To understand how cover crop use changes the restorative properties of dredged sediments, we assessed soil physical and chemical properties, enzymatic activities, and corn yield for plots of dredged sediments with and without a cover crop.

Methods

We assessed soil texture, bulk density, water content, pH, nitrogen, phosphorus, cation exchange capacity, calcium, magnesium, …