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Articles 37681 - 37710 of 256001
Full-Text Articles in Life Sciences
Synthesis, Characterization And Antimicrobial Properties Of Mixed-Ligand Complexes Of Some Metal(Ii) Ions With Barbituric Acid And 1,10-Phenanthroline Ligands, Kayode Taiwo Ishola, Oluwabiyi James Olaoye, Mary Adelaide Oladipo, Omobola Ajibike Odedokun, Oyebanji Oluseun Aboyeji
Synthesis, Characterization And Antimicrobial Properties Of Mixed-Ligand Complexes Of Some Metal(Ii) Ions With Barbituric Acid And 1,10-Phenanthroline Ligands, Kayode Taiwo Ishola, Oluwabiyi James Olaoye, Mary Adelaide Oladipo, Omobola Ajibike Odedokun, Oyebanji Oluseun Aboyeji
Tanzania Journal of Science
Many pathogenic organisms have developed resistance to many antibiotics, which leads to an increase in the spread of many microbial infections. There is an urgent need to find more effective drugs to curb widespread transmission. Hence, this study synthesized and evaluated the antimicrobial activities of mixed-ligand complexes of Cu(II), Co(II), Ni(II), Mn(II), and Zn(II) ions with barbituric acid and 1,10 phenanthroline ligands in effort to find more effective antibiotics. The complexes were characterized using elemental analysis, metal analysis, melting points, solubility tests, and spectroscopic analyses (IR and UV-visible). The antimicrobial activities of the complexes were evaluated against two gram-positive bacteria …
Novel Roles Of The Blm Syndrome Dna Helicase In Genome Maintenance And Mitochondrial Regulation, Brian B. Rodemoyer
Novel Roles Of The Blm Syndrome Dna Helicase In Genome Maintenance And Mitochondrial Regulation, Brian B. Rodemoyer
USF Tampa Graduate Theses and Dissertations
Bloom syndrome (BS) is an extremely rare autosomal recessive genetic disorder caused by defects in the BLM gene. Patients with BS display a broad phenotypic spectrum including abnormally short stature, microcephaly, sun sensitivity, insulin resistance, perpetual oxidative stress, and a ~300-fold greater propensity for developing cancer than the general population. As such, BS patients typically do not live past their 20’s. The BLM gene encodes the BLM helicase, a member of the highly conserved RecQ family of 3’ to 5’ DNA helicases. Most of our cellular understanding of BLM is through its role in DNA damage repair through the homologous …
Skeleton Weed Program 2022/2023: Annual Report To Grain Growers, Department Of Primary Industries And Regional Development, Western Australia
Skeleton Weed Program 2022/2023: Annual Report To Grain Growers, Department Of Primary Industries And Regional Development, Western Australia
Biosecurity published reports
The Skeleton Weed Program has been funded by Western Australian (WA) growers through the Grains, Seed, and Hay Industry Funding Scheme (GSHIFS) since 2010. During that time, the program has grown, placing a greater emphasis on working with farmers, local coordination, support, and encompassing critical research and development.
The Skeleton Weed Program continues to provide critical assistance to grain growers in the management of skeleton weed through the:
• searching of more than 400,000 ha of land to map infested areas for treatment.
• chemical control of skeleton weed on 10,000 ha of infested land.
• successful eradication of skeleton …
Characteristics Of Yogurt And Culture Bacteria As Affected By Ingredients That Help Treat Leaky Gut, Ricardo Jose Santos Aleman
Characteristics Of Yogurt And Culture Bacteria As Affected By Ingredients That Help Treat Leaky Gut, Ricardo Jose Santos Aleman
LSU Doctoral Dissertations
At least 100 million people have leaky gut syndrome. This syndrome is associated with multiple health problems such as diabetes, celiac disease, asthma, multiple sclerosis, and inflammatory bowel disease, costing more than $3 billion per year to treat. L-Glutamine, quercetin, slippery elm bark, marshmallow root, N-acetyl-d-glucosamine (NAG), licorice root, maitake mushrooms, and zinc orotate have been reported to help treat leaky gut.
The objectives were to explore the characteristics of yogurt and culture bacteria as affected by ingredients that help treat leaky gut. In yogurt, the pH, titratable acidity, syneresis, viscosity, color, Streptococcus thermophilus, Lactobacillus bulgaricus, yeast and mold and …
Development Of Photo-Polymerization-Type 3d Printer For High-Viscosity Ceramic Resin Using Cnn-Based Surface Defect Detection, Jin-Kyo Chung, Jeong-Seon Im, Min-Soo Park
Development Of Photo-Polymerization-Type 3d Printer For High-Viscosity Ceramic Resin Using Cnn-Based Surface Defect Detection, Jin-Kyo Chung, Jeong-Seon Im, Min-Soo Park
Faculty, Staff and Student Publications
Due to the high hardness and brittleness of ceramic materials, conventional cutting methods result in poor quality and machining difficulties. Additive manufacturing has also been tried in various ways, but it has many limitations. This study aims to propose a system to monitor surface defects that occur during the printing process based on high-viscosity composite resin that maximizes ceramic powder content in real time using image processing and convolutional neural network (CNN) algorithms. To do so, defects mainly observed on the surface were classified into four types by form: pore, minor, critical, and error, and the effect of each defect …
Co-Targeting Fasn And Mtor Suppresses Uveal Melanoma Growth, Anna Han, Dzmitry Mukha, Vivian Chua, Timothy J Purwin, Manoela Tiago, Usman Baqai, Nelisa Bechtel, Emily Hunter, Meggie Danielson, Mizue Terai, Philip B Wedegaertner, Takami Sato, Solange Landreville, Michael A Davies, Stefan Kurtenbach, J William Harbour, Zachary T Schug, Andrew E Aplin
Co-Targeting Fasn And Mtor Suppresses Uveal Melanoma Growth, Anna Han, Dzmitry Mukha, Vivian Chua, Timothy J Purwin, Manoela Tiago, Usman Baqai, Nelisa Bechtel, Emily Hunter, Meggie Danielson, Mizue Terai, Philip B Wedegaertner, Takami Sato, Solange Landreville, Michael A Davies, Stefan Kurtenbach, J William Harbour, Zachary T Schug, Andrew E Aplin
Faculty, Staff and Student Publications
Uveal melanoma (UM) displays a high frequency of metastasis; however, effective therapies for metastatic UM are limited. Identifying unique metabolic features of UM may provide a potential targeting strategy. A lipid metabolism protein expression signature was induced in a normal choroidal melanocyte (NCM) line transduced with GNAQ (Q209L), a driver in UM growth and development. Consistently, UM cells expressed elevated levels of fatty acid synthase (FASN) compared to NCMs. FASN upregulation was associated with increased mammalian target of rapamycin (mTOR) activation and sterol regulatory element-binding protein 1 (SREBP1) levels. FASN and mTOR inhibitors alone significantly reduced UM cell growth. Concurrent …
Habitat Preference By Himalayan Musk Deer (Moschus Leucogaster) In Shey Phoksundo National Park, Nepal, Rishi Ram Paudel, Aman Oli, Pramod Ghimire
Habitat Preference By Himalayan Musk Deer (Moschus Leucogaster) In Shey Phoksundo National Park, Nepal, Rishi Ram Paudel, Aman Oli, Pramod Ghimire
Journal of Bioresource Management
Himalayan Musk Deer (Moschus leucogaster) is distributed across the mid-mountainous region from the elevation of 3000 m to 4000 m. Shey Phoskundo National Park lies in western Nepal and Shey Phoksundo Rural Municipality serves as the prime habitat in this region. The main objective of this study was to find out the habitat preference of Himalayan Musk Deer and to evaluate all the suitable habitats. Transects survey were done to evaluate the preferred attributes of the species. Pellets were rarely found where the crown cover was more than 75 % but the resting sites were abundantly found there …
Endophytic Potential Of Entomopathogenic Fungi For The Remediation Of Wastewater, Huda Bilal, Hasnain Raza, Sana Sarfaraz, Danyal Haider Khan
Endophytic Potential Of Entomopathogenic Fungi For The Remediation Of Wastewater, Huda Bilal, Hasnain Raza, Sana Sarfaraz, Danyal Haider Khan
Journal of Bioresource Management
Phytoremediation has the potential to significantly reduce water contamination caused by excessive harmful chemicals. The degradative properties of fungi are used in fungal phytoremediation to eliminate or neutralise the hazardous pollutants present in water. The goal of the current study was to endophytize water lettuce with the two entomopathogenic fungus Metarhizium anisopilae and Trichoderma harazium. The plant is inoculated with the fungus using the root-dipping procedure. There were two main treatments and a control all with five replications. The analysis of plant and wastewater were analyzed initially like frequency of fungus remained in plant weight, root length and for …
Study Of Production And Adaptation Characters Of Some Newly Obtained Genotypes Of Durum Wheat (Triticum Durum Desf.) In Sub-Humid Region (El Harrouch North-Eastern Of Algeria), Lamia Bourouh, Nabila Souilah, Boulacel Mouad, Ghania Chaib, Tahar Hazmoune, Bendif Hamdi
Study Of Production And Adaptation Characters Of Some Newly Obtained Genotypes Of Durum Wheat (Triticum Durum Desf.) In Sub-Humid Region (El Harrouch North-Eastern Of Algeria), Lamia Bourouh, Nabila Souilah, Boulacel Mouad, Ghania Chaib, Tahar Hazmoune, Bendif Hamdi
Journal of Bioresource Management
The experiment was carried out at DAOUDI Larbi pilot farm in El Harrouch, during the 2021/2022 crop year, under sub-humid weather conditions. The main objective of this research is based on the study of production and adaptation characters of seven durum wheat newly obtained genotypes (Triticum durum Desf.). The results of descriptive sheets according to UPOV recommendations (2014-2017), showed diversity between the varieties studied, such as: plant height, straw section, awns (presence, disposition, anthocyanin pigmentation, color, and length), ear (density, color, shape, length and glaucescence), lower glume (shape, color, weight and shape of shoulder, length and curvature of beak), …
A Review On Antibiotic Resistance And The Use Of Medicinal Plants In The Management Of Uropathogenic Bacteria, Hubza Ruatt Khan, Mehvish Javeed, Iqra Batool, Rabeea Anwar, Asma Ashraf, Sara Janiad
A Review On Antibiotic Resistance And The Use Of Medicinal Plants In The Management Of Uropathogenic Bacteria, Hubza Ruatt Khan, Mehvish Javeed, Iqra Batool, Rabeea Anwar, Asma Ashraf, Sara Janiad
Journal of Bioresource Management
UTIs are the most prevalent infections and are caused by uropathogenic microbes such as Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis, Pseudomonas aeruginosa, Staphylococcus aureus, and Enterococcus spp. Antibiotic resistance has hampered the management of UTIs over the years, with direct repercussions on the treatment cost, the infection severity, and the duration of hospitalization. This review discussed the route of infections, risk factors connected to UTIs, antibiotic resistance issues as well as an alternative therapy to overcome the problem of antibiotic resistance. The medicinal plants, which have been utilized for thousands of years to cure a variety of ailments, represent a …
Assessment Of Antimicrobial Competence Of Epiphytes And Endophytes From Osmium Basilicum And Trigonella Foenum Graecum, Iram Asim, Atia Iqbal, Muhammad Ikrama Tanveer
Assessment Of Antimicrobial Competence Of Epiphytes And Endophytes From Osmium Basilicum And Trigonella Foenum Graecum, Iram Asim, Atia Iqbal, Muhammad Ikrama Tanveer
Journal of Bioresource Management
Plant-associated bacteria are an unexplored group of microorganisms that has enormous potential. These bacteria are the source of finding new antimicrobial substances. The present study aimed to isolate and characterize the epiphytes and endophytes from Osmium basilicum and Trigonella foenum graecum plants and to determine their antimicrobial potential against pathogenic bacteria from Nishtar Hospital Multan, Pakistan. The sum of 18 stems and roots along leaf specimens were assembled as of the plant's Osmium basilicum plus Trigonella foenum graecum as of the distinct locales of the Multan city. Overall 73 bacterial strains were isolated and their colony morphology, gram staining, spore …
Shower Thoughts: Why Scientists Should Spend More Time In The Rain, John T. Van Stan Ii, Scott T. Allen, Douglas P. Aubrey, Z. Carter Berry, Matthew Biddick, Miriam A.M.J. Coenders-Gerrits, Paolo Giordani, Sybil G. Gotsch, Ethan D. Gutmann, Yakov Kuzyakov, Donát Magyar, Valentina S.A. Mella, Kevin E. Mueller, Alexandra G. Ponette-González, Philipp Porada, Carla E. Rosenfeld, Jack Simmons
Shower Thoughts: Why Scientists Should Spend More Time In The Rain, John T. Van Stan Ii, Scott T. Allen, Douglas P. Aubrey, Z. Carter Berry, Matthew Biddick, Miriam A.M.J. Coenders-Gerrits, Paolo Giordani, Sybil G. Gotsch, Ethan D. Gutmann, Yakov Kuzyakov, Donát Magyar, Valentina S.A. Mella, Kevin E. Mueller, Alexandra G. Ponette-González, Philipp Porada, Carla E. Rosenfeld, Jack Simmons
Biological, Geological, and Environmental Faculty Publications
Stormwater is a vital resource and dynamic driver of terrestrial ecosystem processes. However, processes controlling interactions during and shortly after storms are often poorly seen and poorly sensed when direct observations are substituted with technological ones. We discuss how human observations complement technological ones and the benefits of scientists spending more time in the storm. Human observation can reveal ephemeral storm-related phenomena such as biogeochemical hot moments, organismal responses, and sedimentary processes that can then be explored in greater resolution using sensors and virtual experiments. Storm-related phenomena trigger lasting, oversized impacts on hydrologic and biogeochemical processes, organismal traits or functions, …
Withaferin A And Immune Checkpoint Blocker Therapy For The Treatment Of Non-Small Cell Lung Cancer, Roukiah Khalil
Withaferin A And Immune Checkpoint Blocker Therapy For The Treatment Of Non-Small Cell Lung Cancer, Roukiah Khalil
USF Tampa Graduate Theses and Dissertations
Lung cancer is the first cause of cancer-related deaths in both men and women with an overall five-year survival rate of 28%. Although immune checkpoint blockers (ICBs) are currently FDA-approved for the treatment of non-small cell lung cancer (NSCLC), only 17-20% of patients achieve durable responses by the induction of immunologic memory. The lack of response in most patients can be attributed to the tumor-intrinsic or tumor-extrinsic immune resistance mechanisms. A biomarker of importance is the Programmed Death Ligand-1 (PD-L1), as higher PD-L1 expression is usually associated with a better response to ICBs. Although studies have attempted to combine ICBs …
Immune Cells Localize To Sites Of Corneal Erosions In C57bl/6 Mice., Phuong M. Le, Sonali Pal-Ghosh, A. Menko, Mary Ann Stepp
Immune Cells Localize To Sites Of Corneal Erosions In C57bl/6 Mice., Phuong M. Le, Sonali Pal-Ghosh, A. Menko, Mary Ann Stepp
Computational Medicine Center Faculty Papers
Recurrent epithelial erosions develop in the cornea due to prior injury or genetic predisposition. Studies of recurrent erosions in animal models allow us to gain insight into how erosions form and are resolved. While slowing corneal epithelial cell migration and reducing their proliferation following treatment with mitomycin C reduce erosion formation in mice after sterile debridement injury, additional factors have been identified related to cytokine expression and immune cell activation. The relationship between recruitment of immune cells to the region of the cornea where erosions form and their potential roles in erosion formation and/or erosion repair remains unexplored in the …
Influence Of Woody Vegetation Composition And Structure On Fuels And Prescribed Fire In Mountain Longleaf Restoration, Collin J. Anderson
Influence Of Woody Vegetation Composition And Structure On Fuels And Prescribed Fire In Mountain Longleaf Restoration, Collin J. Anderson
Master of Science in Integrative Biology Theses
Longleaf pine (LLP) ecosystems have experienced a widespread ecological state shift largely due to fire exclusion which has allowed mesophytes, i.e., shade-tolerant, often fire-sensitive species to encroach, reducing flammability and biodiversity through a process known as “mesophication.” Although prescribed fire is commonly used to reverse mesophication, fire behavior, and thus prescribed fire utility for this purpose, is poorly characterized in mixed pine-hardwood stands with mesophyte encroachment. This study aimed to identify mechanisms by which tree composition, structure, and fuels contribute to fire behavior, focusing on the understudied mountain longleaf pine (MLLP) ecoregion in northwest Georgia. I hypothesized that woody vegetation …
Description Of The Bioluminescent Emission Spectrum Of Bicellonycha Amoena Gorham, 1880 (Coleoptera: Lampyridae) In Guatemala, Eduardo A. Arrivillaga-Cano, Maria P. Muñoz-Soler, Diegopáblo Pineda, Edgar R. Rosales, Jack C. Schuster
Description Of The Bioluminescent Emission Spectrum Of Bicellonycha Amoena Gorham, 1880 (Coleoptera: Lampyridae) In Guatemala, Eduardo A. Arrivillaga-Cano, Maria P. Muñoz-Soler, Diegopáblo Pineda, Edgar R. Rosales, Jack C. Schuster
Insecta Mundi
Bicellonycha amoena (Gorham, 1880) (Coleoptera: Lampyridae) usually flies one meter above ground level over grass, water, or open areas, where males produce a simple single flash every 2–4 seconds, having their most active flashing period from mid to late dusk and early night. In addition, nothing else is known about the behavior of this species. We conducted field observations at the “Mayan Golf Club” in Guatemala Department, and Santiago Sacatepéquez, Sacatepéquez Department, Guatemala; and analyzed B. amoena flashes with a spectroscope. Fireflies displayed a lime-green bioluminescence color. The male flashing activity began ~30 minutes after sunset and lasted approximately 70 …
Classim: A Relational Database Driven Crop Model Interface, Dennis Timlin, David Fleisher, Maura Maura, Kirsten Paff, Wenguang Sun, Sahila Beegum, Sanai Li, Zhuangji Wang, Vangimalla Reddy
Classim: A Relational Database Driven Crop Model Interface, Dennis Timlin, David Fleisher, Maura Maura, Kirsten Paff, Wenguang Sun, Sahila Beegum, Sanai Li, Zhuangji Wang, Vangimalla Reddy
Department of Agronomy and Horticulture: Faculty Publications
Crop models are valuable tools for examining the interactions of cultivar characteristics, environment, and management practices, and how they affect crop growth and development. The difficulty in finding all the data needed to set up a simulation can often deter potential users from utilizing a crop model. Model interfaces are necessary to make these complex tools accessible to end-users who may lack the expertise needed to work with the models directly, but who would benefit from the information generated by the models. As crop models vary in terms of input and output structures, there is no one universally compatible interface, …
Conversion Of Native Grassland To Coniferous Forests Decreased Stocks Of Soil Organic Carbon And Microbial Biomass, Lidong Li, Elnaz Hosseiniaghdam, Rhae A. Drijber, Elizabeth Jeske, Tala Awada, J. Hiller, Michael Kaiser
Conversion Of Native Grassland To Coniferous Forests Decreased Stocks Of Soil Organic Carbon And Microbial Biomass, Lidong Li, Elnaz Hosseiniaghdam, Rhae A. Drijber, Elizabeth Jeske, Tala Awada, J. Hiller, Michael Kaiser
Department of Agronomy and Horticulture: Faculty Publications
Aims Encroachment of woody species into grasslands is a global phenomenon that affects ecosystem services, including soil organic carbon (SOC) storage and microbial community structure. We determined stocks of SOC and soil microbial biomass as affected by conversion of grasslands to coniferous forests.
Methods We examined SOC and soil δ13C signatures under three vegetation covers: native grasslands, eastern redcedar (Juniperus virginiana), and ponderosa pine (Pinus ponderosa), at six soil depths (0 − 10, 10 − 30, 30 − 100, 100 − 170, 170 − 240, 240 − 300 cm). Fatty acid methyl esters (FAMEs) …
Tillage, Green Manuring And Crop Residue Management Impacts On Crop Productivity, Potassium Use Efficiency And Potassium Fractions Under Rice-Wheat System, Sandeep Sharma, Pritpal Singh, Hayssam M. Ali, Manzer Hussain Siddiqui, Javed Iqbal
Tillage, Green Manuring And Crop Residue Management Impacts On Crop Productivity, Potassium Use Efficiency And Potassium Fractions Under Rice-Wheat System, Sandeep Sharma, Pritpal Singh, Hayssam M. Ali, Manzer Hussain Siddiqui, Javed Iqbal
Department of Agronomy and Horticulture: Faculty Publications
The conventional crop production practices including intensive tillage and open field crop residue burning in world’ largest rice-wheat system (RWS) are adversely affecting crop productivity besides deteriorating natural resources and ecosystems’ sustainability. In order to improve system productivity, potassium (K) use efficiency and apparent K balance, adoption of conservation tillage in a RWS with residue management is considered highly effective. We therefore, studied the effect of wheat straw retention and green manure (GM) in rice (main plot treatment), and tillage and rice residue management in subsequent wheat (sub-plot treatments) on crop productivity, K use efficiency and its transformation amongst different …
Use Of Electronic Ecological Momentary Assessment Methodologies In Physical Activity, Sedentary Behavior, And Sleep Research In Young Adults: Systematic Review, Kimberly R. Hartson, Luz Huntington-Moskos, Clara G. Sears, Gina Genova, Cara Mathis, Wessly Ford, Ryan E. Rhodes
Use Of Electronic Ecological Momentary Assessment Methodologies In Physical Activity, Sedentary Behavior, And Sleep Research In Young Adults: Systematic Review, Kimberly R. Hartson, Luz Huntington-Moskos, Clara G. Sears, Gina Genova, Cara Mathis, Wessly Ford, Ryan E. Rhodes
Faculty and Staff Scholarship
Background: Recent technological advances allow for the repeated sampling of real-time data in natural settings using electronic ecological momentary assessment (eEMA). These advances are particularly meaningful for investigating physical activity, sedentary behavior, and sleep in young adults who are in a critical life stage for the development of healthy lifestyle behaviors.
Objective: This study aims to describe the use of eEMA methodologies in physical activity, sedentary behavior, and sleep research in young adults.
Methods: The PubMed, CINAHL, PsycINFO, Embase, and Web of Science electronic databases were searched through August 2022. Inclusion criteria were use of eEMA; sample of young adults …
A Phase I Study Of Milademetan (Ds3032b) In Combination With Low Dose Cytarabine With Or Without Venetoclax In Acute Myeloid Leukemia: Clinical Safety, Efficacy, And Correlative Analysis, Jayastu Senapati, Muharrem Muftuoglu, Jo Ishizawa, Hussein A Abbas, Sanam Loghavi, Musa Yilmaz, Samuel I Dara, Mahesh Basyal, Li Li, Kiran Naqvi, Rasoul Pourebrahim, Elias J Jabbour, Steven M Kornblau, Nicholas J Short, Naveen Pemmaraju, Guillermo Garcia-Manero, Farhad Ravandi, Joseph Khoury, Naval Daver, Hagop M Kantarjian, Michael Andreeff, Courtney D Dinardo
A Phase I Study Of Milademetan (Ds3032b) In Combination With Low Dose Cytarabine With Or Without Venetoclax In Acute Myeloid Leukemia: Clinical Safety, Efficacy, And Correlative Analysis, Jayastu Senapati, Muharrem Muftuoglu, Jo Ishizawa, Hussein A Abbas, Sanam Loghavi, Musa Yilmaz, Samuel I Dara, Mahesh Basyal, Li Li, Kiran Naqvi, Rasoul Pourebrahim, Elias J Jabbour, Steven M Kornblau, Nicholas J Short, Naveen Pemmaraju, Guillermo Garcia-Manero, Farhad Ravandi, Joseph Khoury, Naval Daver, Hagop M Kantarjian, Michael Andreeff, Courtney D Dinardo
Faculty, Staff and Student Publications
In TP53 wild-type acute myeloid leukemia (AML), inhibition of MDM2 can enhance p53 protein expression and potentiate leukemic cell apoptosis. MDM2 inhibitor (MDM2i) monotherapy in AML has shown modest responses in clinical trials but combining options of MDM2i with other potent AML-directed agents like cytarabine and venetoclax could improve its efficacy. We conducted a phase I clinical trial (NCT03634228) to study the safety and efficacy of milademetan (an MDM2i) with low-dose cytarabine (LDAC)±venetoclax in adult patients with relapsed refractory (R/R) or newly diagnosed (ND; unfit) TP53 wild-type AML and performed comprehensive CyTOF analyses to interrogate multiple signaling pathways, …
A Phase I Study Of Milademetan (Ds3032b) In Combination With Low Dose Cytarabine With Or Without Venetoclax In Acute Myeloid Leukemia: Clinical Safety, Efficacy, And Correlative Analysis, Jayastu Senapati, Muharrem Muftuoglu, Jo Ishizawa, Hussein A Abbas, Sanam Loghavi, Musa Yilmaz, Samuel I Dara, Mahesh Basyal, Li Li, Kiran Naqvi, Rasoul Pourebrahim, Elias J Jabbour, Steven M Kornblau, Nicholas J Short, Naveen Pemmaraju, Guillermo Garcia-Manero, Farhad Ravandi, Joseph Khoury, Naval Daver, Hagop M Kantarjian, Michael Andreeff, Courtney D Dinardo
A Phase I Study Of Milademetan (Ds3032b) In Combination With Low Dose Cytarabine With Or Without Venetoclax In Acute Myeloid Leukemia: Clinical Safety, Efficacy, And Correlative Analysis, Jayastu Senapati, Muharrem Muftuoglu, Jo Ishizawa, Hussein A Abbas, Sanam Loghavi, Musa Yilmaz, Samuel I Dara, Mahesh Basyal, Li Li, Kiran Naqvi, Rasoul Pourebrahim, Elias J Jabbour, Steven M Kornblau, Nicholas J Short, Naveen Pemmaraju, Guillermo Garcia-Manero, Farhad Ravandi, Joseph Khoury, Naval Daver, Hagop M Kantarjian, Michael Andreeff, Courtney D Dinardo
Faculty, Staff and Student Publications
In TP53 wild-type acute myeloid leukemia (AML), inhibition of MDM2 can enhance p53 protein expression and potentiate leukemic cell apoptosis. MDM2 inhibitor (MDM2i) monotherapy in AML has shown modest responses in clinical trials but combining options of MDM2i with other potent AML-directed agents like cytarabine and venetoclax could improve its efficacy. We conducted a phase I clinical trial (NCT03634228) to study the safety and efficacy of milademetan (an MDM2i) with low-dose cytarabine (LDAC)±venetoclax in adult patients with relapsed refractory (R/R) or newly diagnosed (ND; unfit) TP53 wild-type AML and performed comprehensive CyTOF analyses to interrogate multiple signaling pathways, the p53-MDM2 …
The Effect Of Dairy Cow Genotype On Modelled Greenhouse Gas Emissions Derived From Pasture Based Milk Production Systems, Dan K. Lovett, L. Shalloo, P. Dillon, Frank O'Mara
The Effect Of Dairy Cow Genotype On Modelled Greenhouse Gas Emissions Derived From Pasture Based Milk Production Systems, Dan K. Lovett, L. Shalloo, P. Dillon, Frank O'Mara
IGC Proceedings (1977-2023)
A three-year systems comparison study was undertaken to see if progressively increasing the genetic potential for milk production of the dairy cow is desirable within pastoral based systems of spring milk production (Kennedy et al., 2002). The production data was inputted into the Moorepark Dairy System Model (MDSM) (Shalloo et al., 2004) to describe the economic, biological and production efficiency of each system. Output was then used to model whole farm greenhouse gas (GHG) emissions (Lovett et al., in press) from the nine systems studied (three concentrate levels by three genotype levels). Only the genotype effects are …
Methane Of Animal Origin In Cattle Fed High Or Low Tannin Sorghum Silage, T. T. Berchielli, S. G. Oliveira, M. P. Pedreira, O. Primavesi, M. A. Lima, R. Frighetto
Methane Of Animal Origin In Cattle Fed High Or Low Tannin Sorghum Silage, T. T. Berchielli, S. G. Oliveira, M. P. Pedreira, O. Primavesi, M. A. Lima, R. Frighetto
IGC Proceedings (1977-2023)
The harmful or beneficial effects associated with the presence of tannin in plants depends on its concentration and form. One of these beneficial effects is the reduction of the production of methane in the rumen (Woodward et al., 2001). This study financed by FAPESP aimed to evaluat the effect of diets containing low or high tannin sorghum silage supplements on dry matter intake (DMI) and methane production in cattle.
Field Measurements Of Ruminal Methane Of Cattle Grazing Tropical Grasses, M. P. Pedreira, O. Primavesi, M. A. Lima, R. Frighetto, T. T. Berchielli
Field Measurements Of Ruminal Methane Of Cattle Grazing Tropical Grasses, M. P. Pedreira, O. Primavesi, M. A. Lima, R. Frighetto, T. T. Berchielli
IGC Proceedings (1977-2023)
Ruminal methane production represents energy losses from ingested feed that should be utilised to maintain body weight or to generate products. Quantitatively, daily methane production varies according to amount and quality of ingested dry matter (DM), as well as physiological status of the animal.
Hedgerow Systems And Livestock In Philippine Grasslands: Ghg Emissions, D. B. Magcale-Macandog, E. Abucay, R. G. Visco, R. N. Miole, E. L. Abas, G. M. Comajig, A. D. Calub
Hedgerow Systems And Livestock In Philippine Grasslands: Ghg Emissions, D. B. Magcale-Macandog, E. Abucay, R. G. Visco, R. N. Miole, E. L. Abas, G. M. Comajig, A. D. Calub
IGC Proceedings (1977-2023)
Hedgerow systems are widely adopted in the smallholder farms in the sloping grassland areas of Claveria, Mindanao, Philippines. The system is effective in addressing soil erosion problems and in conserving the topsoil. Gmelina arborea and Eucalyptus deglupta are two fast-growing timber species that are planted in hedgerow systems while maize is planted in the alley areas in between the hedgerows. Livestock holdings are widespread in Claveria, with 74% of the households having livestock. Cattle and carabao are the most common livestock in smallholder farms providing draught power for land preparation and transportation. In hedgerow systems, fodder tree leaves and crop …
The Effect Of Soil Type And Climate On Modelled Greenhouse Gas Emissions Derived From Pasture Based Milk Production Systems, Dan K. Lovett, L. Shalloo, P. Dillon, Frank O'Mara
The Effect Of Soil Type And Climate On Modelled Greenhouse Gas Emissions Derived From Pasture Based Milk Production Systems, Dan K. Lovett, L. Shalloo, P. Dillon, Frank O'Mara
IGC Proceedings (1977-2023)
The ability of spring calving dairy farmers to exploit herbage production can be limited by soil type and climatic conditions. Previous work, using the Moorepark Dairy System Model (MDSM) (Shalloo et al., 2004) demonstrated differences in terms of biological and production efficiency for two contrasting sites. This study models whole farm greenhouse gas (GHG) emissions (Lovett et al., in press) from two dairy systems, the Moorepark Standard System (MSS, Co. Cork) and the Kilmaley Standard System (KSS,Co. Clare), classified as lower and high rainfall (1025 and 1614 mm yr) and free draining versus poor draining respectively.
Quantification Of Co2 Exchange In Grassland Ecosystems Of The World Using Tower Measurements, Modeling And Remote Sensing, Tagir Gilmanov, M. W. Demment, B. K. Wylie, K. Akshalov, D. D. Baldocchi, L. Belelli, J. A. Bradford, G. G. Burba, R. L. Coulter, W. A. Dugas, W. E. Emmerich, L. B. Flanagan, A. B. Frank, J. Fuher, M. R. Haferkamp, M. B. Jones, D. A. Johnson, T. Laurila, A. Lohila, T. P. Meyers, P. C. Mielnick, J. A. Morgan, M. Nasyrov, C. E. Owensby, M. S. Pekour, K. Pilegaard, A. Raschi, N. Z. Saliendra, M. J. Sanz, P. L. Sims, R. H. Skinner, J. F. Sousanna, A. E. Suyker, L. L. Tieszen, Z. Tuba, R. Valentini, S. B. Verma, E. A. Laca
Quantification Of Co2 Exchange In Grassland Ecosystems Of The World Using Tower Measurements, Modeling And Remote Sensing, Tagir Gilmanov, M. W. Demment, B. K. Wylie, K. Akshalov, D. D. Baldocchi, L. Belelli, J. A. Bradford, G. G. Burba, R. L. Coulter, W. A. Dugas, W. E. Emmerich, L. B. Flanagan, A. B. Frank, J. Fuher, M. R. Haferkamp, M. B. Jones, D. A. Johnson, T. Laurila, A. Lohila, T. P. Meyers, P. C. Mielnick, J. A. Morgan, M. Nasyrov, C. E. Owensby, M. S. Pekour, K. Pilegaard, A. Raschi, N. Z. Saliendra, M. J. Sanz, P. L. Sims, R. H. Skinner, J. F. Sousanna, A. E. Suyker, L. L. Tieszen, Z. Tuba, R. Valentini, S. B. Verma, E. A. Laca
IGC Proceedings (1977-2023)
Grasslands cover significant areas in nontropical regions, perform essential biogeochemical functions and represent important natural and agricultural resource. Nevertheless, in contrast to forests and agroecosystems, no flux measurement-based global summary of their CO2 exchange, sequestration potential, and role in mitigation of the greenhouse effect were available.
The Influence Of Local Immigration And Extinction Of Species On Spatial Heterogeneity Of Vegetation In Semi-Natural Grasslands In Japan, Taisuke Yasuda, Masae Shiyomi, T. Egawa, K. Sei, R. Ishikawa, S. Takahashi
The Influence Of Local Immigration And Extinction Of Species On Spatial Heterogeneity Of Vegetation In Semi-Natural Grasslands In Japan, Taisuke Yasuda, Masae Shiyomi, T. Egawa, K. Sei, R. Ishikawa, S. Takahashi
IGC Proceedings (1977-2023)
Spatiotemporal variation in the local immigration and extinction of species in a community may form and change the spatial heterogeneity (SH) of vegetation but few studies have evaluated the influences of these processes on SH. SH often occurs in grassland grazed by cattle and sheep. Understanding the formation and dynamics of SH is important because SH profoundly affects local and regional ecological processes. We propose a new way to quantify the effect of the local immigration and extinction of species on SH, and try to clarify the influence of the processes on SH
Cattle Slurry Amended With Nitrification Inhibitors: Effects On Nitrous Oxide, Dinitrogen And Methane Emissions, J. P. Carneiro, L. Cardenas, D. Hatch, H. Trindade, J. Hawkins, David Scholefield, D. Chadwick
Cattle Slurry Amended With Nitrification Inhibitors: Effects On Nitrous Oxide, Dinitrogen And Methane Emissions, J. P. Carneiro, L. Cardenas, D. Hatch, H. Trindade, J. Hawkins, David Scholefield, D. Chadwick
IGC Proceedings (1977-2023)
In recent decades, a very intensive dairy farming system has been developed in northern Portugal. Considering the appreciable amounts of slurry generated and the small farm areas for spreading, this activity involves large annual inputs of N with the risk of undesirable consequences for the environment. Emission of greenhouse gases from agricultural sources, such as N2O (originating from nitrification and denitrification) and CH4, therefore need to be reduced. The aim of this laboratory experiment was to evaluate the effectiveness of two nitrification inhibitors (dicyandiamide (DCD) and 3,4-dimethylpyrazole phosphate (DMPP)) in reducing nitrification and subsequent denitrification after …