Life Sciences Commons^™

Proteogenomic Approaches For The Identification Of Nf1/Neurofibromin-Depleted Estrogen Receptor-Positive Breast Cancers For Targeted Treatment, Beom-Jun Kim, Ze-Yi Zheng, Jonathan T Lei, Matthew V Holt, Anran Chen, Diana Fandino, Hilda Kennedy, Yongchao Dou, María Del Rosario Chica-Parrado, Emmanuel Bikorimana, Dan Ye, Yunguan Wang, Ariella B Hanker, Nada Mohamed, Susan G Hilsenbeck, Bora Lim, Jaya Ruth Asirvatham, Arun Sreekumar, Bing Zhang, George Miles, Meenakshi Anurag, Matthew J Ellis, Eric C Chang

Faculty, Staff and Student Publications

NF1 is a key tumor suppressor that represses both RAS and estrogen receptor-α (ER) signaling in breast cancer. Blocking both pathways by fulvestrant (F), a selective ER degrader, together with binimetinib (B), a MEK inhibitor, promotes tumor regression in NF1-depleted ER+ models. We aimed to establish approaches to determine how NF1 protein levels impact B+F treatment response to improve our ability to identify B+F sensitive tumors. We examined a panel of ER+ patient-derived xenograft (PDX) models by DNA and mRNA sequencing and found that more than half of these models carried an NF1 shallow deletion and generally have low mRNA …

The Clinicogenomic Landscape Of Induction Failure In Childhood And Young Adult T-Cell Acute Lymphoblastic Leukemia, David O'Connor, Jonas Demeulemeester, Lucia Conde, Amy Kirkwood, Kent Fung, Gianna Bloye, Sunniyat Rahman, Jeremy Hancock, Caroline Bateman, Sarah Inglott, Jon Mee, Javier Herrero, Peter Van Loo, Anthony V Moorman, Ajay Vora, Marc R Mansour

Faculty, Staff and Student Publications

PURPOSE: Failure to respond to induction chemotherapy portends a poor outcome in childhood acute lymphoblastic leukemia (ALL) and is more frequent in T-cell ALL (T-ALL) than B-cell ALL. We aimed to address the limited understanding of clinical and genetic factors that influence outcome in a cohort of patients with T-ALL induction failure (IF).

METHODS: We studied all cases of T-ALL IF on two consecutive multinational randomized trials, UKALL2003 and UKALL2011, to define risk factors, treatment, and outcomes. We performed multiomic profiling to characterize the genomic landscape.

RESULTS: IF occurred in 10.3% of cases and was significantly associated with increasing age, …

Federated Benchmarking Of Medical Artificial Intelligence With Medperf, Alexandros Karargyris, Renato Umeton, Micah J Sheller, Alejandro Aristizabal, Johnu George, Sarthak Pati, Maximilian Zenk, Ujjwal Baid, Prakash Narayana Moorthy, Alexander Chowdhury, Junyi Guo, Sahil Nalawade, Jacob Rosenthal, David Kanter, Maria Xenochristou, Daniel J Beutel, Verena Chung, Timothy Bergquist, James Eddy, Abubakar Abid, Lewis Tunstall, Omar Sanseviero, Dimitrios Dimitriadis, Yiming Qian, Xinxing Xu, Yong Liu, Rick Siow Mong Goh, Srini Bala, Victor Bittorf, Sreekar Reddy Puchala, Biagio Ricciuti, Soujanya Samineni, Eshna Sengupta, Akshay Chaudhari, Cody Coleman, Bala Desinghu, Gregory Diamos, Debo Dutta, Diane Feddema, Grigori Fursin, Xinyuan Huang, Satyananda Kashyap, Nicholas Lane, Indranil Mallick, Fets Consortium, Brats-2020 Consortium, Ai4safechole Consortium, Pietro Mascagni, Virendra Mehta, Cassiano Ferro Moraes, Vivek Natarajan, Nikola Nikolov, Nicolas Padoy, Gennady Pekhimenko, Vijay Janapa Reddi, G Anthony Reina, Pablo Ribalta, Abhishek Singh, Jayaraman J Thiagarajan, Jacob Albrecht, Thomas Wolf, Geralyn Miller, Huazhu Fu, Prashant Shah, Daguang Xu, Poonam Yadav, David Talby, Mark M Awad, Jeremy P Howard, Michael Rosenthal, Luigi Marchionni, Massimo Loda, Jason M Johnson, Spyridon Bakas, Peter Mattson

Faculty, Staff and Student Publications

Medical artificial intelligence (AI) has tremendous potential to advance healthcare by supporting and contributing to the evidence-based practice of medicine, personalizing patient treatment, reducing costs, and improving both healthcare provider and patient experience. Unlocking this potential requires systematic, quantitative evaluation of the performance of medical AI models on large-scale, heterogeneous data capturing diverse patient populations. Here, to meet this need, we introduce MedPerf, an open platform for benchmarking AI models in the medical domain. MedPerf focuses on enabling federated evaluation of AI models, by securely distributing them to different facilities, such as healthcare organizations. This process of bringing the model …

Histone Demethylase Kdm5d Upregulation Drives Sex Differences In Colon Cancer, Jiexi Li, Zhengdao Lan, Wenting Liao, James W Horner, Xueping Xu, Yohei Yoshihama, Hong Seok Shim, Max Slotnik, Kyle A Labella, Chang-Jiun Wu, Kenneth Dunner, Wen-Hao Hsu, Rumi Lee, Isha Khanduri, Christopher Terranova, Kadir Akdemir, Deepavali Chakravarti, Xiaoying Shang, Denise J Spring, Y Alan Wang, Ronald A Depinho

Faculty, Staff and Student Publications

Sex exerts a profound impact on cancer incidence, spectrum and outcomes, yet the molecular and genetic bases of such sex differences are ill-defined and presumptively ascribed to X-chromosome genes and sex hormones1. Such sex differences are particularly prominent in colorectal cancer (CRC) in which men experience higher metastases and mortality. A murine CRC model, engineered with an inducible transgene encoding oncogenic mutant KRASG12D and conditional null alleles of Apc and Trp53 tumour suppressors (designated iKAP)2, revealed higher metastases and worse outcomes specifically in males with oncogenic mutant KRAS (KRAS*) CRC. Integrated cross-species molecular and transcriptomic analyses identified Y-chromosome gene histone …

Neoadjuvant Immunotherapy For Advanced, Resectable Non-Small Cell Lung Cancer: A Systematic Review And Meta-Analysis, Yajing Wu, Vivek Verma, Carl M Gay, Yujia Chen, Fei Liang, Jianing Wang, Zhouguang Hui, Min Zhao, Jun Wang, Joe Y Chang

Faculty, Staff and Student Publications

Background: Neoadjuvant immunotherapy (nIT) is a rapidly emerging paradigm for advanced resectable non-small cell lung cancer (NSCLC). The objectives of this PRISMA/MOOSE/PICOD-guided systematic review and meta-analysis were (1) to assess the safety and efficacy of nIT, (2) to compare the safety and efficacy of neoadjuvant chemoimmunotherapy (nCIT) versus chemotherapy alone (nCT), and (3) to explore predictors of pathologic response with nIT and their association with outcomes.

Methods: Eligibility was resectable stage I-III NSCLC and the receipt of programmed death-1/programmed cell death ligand-1 (PD-L1)/cytotoxic T-lymphocyte-associated antigen-4 inhibitors before resection; other forms and modalities of neoadjuvant and/or adjuvant therapies were allowed. For …

Transplantation Referral Patterns For Patients With Newly Diagnosed Higher-Risk Myelodysplastic Syndromes And Acute Myeloid Leukemia At Academic And Community Sites In The Connect® Myeloid Disease Registry: Potential Barriers To Care, Benjamin Tomlinson, Marcos De Lima, Christopher R Cogle, Michael A Thompson, David L Grinblatt, Rami S Komrokji, Michael R Savona, Mikkael A Sekeres, Mehrdad Abedi, Guillermo Garcia-Manero, Sandra E Kurtin, Jaroslaw P Maciejewski, Jay L Patel, Dennis A Revicki, Tracy I George, E Dawn Flick, Pavel Kiselev, Chrystal U Louis, Irene S Degutis, Melissa Nifenecker, Harry P Erba, David P Steensma, Bart L Scott

Faculty, Staff and Student Publications

Hematopoietic stem cell transplantation (HCT) is indicated for patients with higher-risk (HR) myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML). Age, performance status, patient frailty, comorbidities, and nonclinical factors (eg, cost, distance to site) are all recognized as important clinical factors that can influence HCT referral patterns and patient outcomes; however, the proportion of eligible patients referred for HCT in routine clinical practice is largely unknown. This study aimed to assess patterns of consideration for HCT among patients with HR-MDS and AML enrolled in the Connect® Myeloid Disease Registry at community/government (CO/GOV)- or academic (AC)-based sites, as well as to …

Single-Cell Profiling Of Tumor Immune Microenvironment Reveals Immune Irresponsiveness In Gastric Signet-Ring Cell Carcinoma, Jing Chen, Kuai Liu, Yikai Luo, Muxing Kang, Jun Wang, Jia Qi, Beidi Wang, Yaxuan Han, Le Shi, Kefan Wang, Xiaying Han, Xiaojing Ma, Wei Liu, Yuan Ding, Liangjing Wang, Han Liang, Lie Wang, Jian Chen

Faculty, Staff and Student Publications

Background & aims: Gastric cancer (GC) is a major cancer type characterized by high heterogeneity in both tumor cells and the tumor immune microenvironment (TIME). One intractable GC subtype is gastric signet-ring cell carcinoma (GSRCC), which is associated with poor prognosis. However, it remains unclear what the GSRCC TIME characteristics are and how these characteristics may contribute to clinical outcomes.

Methods: We enrolled 32 patients with advanced GC of diverse subtypes and profiled their TIME using an immune-targeted single-cell profiling strategy, including (1) immune-targeted single-cell RNA sequencing (n = 20 patients) and (2) protein expression profiling by a targeted antibody …

Eliminating Breast Surgery For Invasive Cancer With Exceptional Response To Neoadjuvant Systemic Therapy: Prospective Multicenter Clinical Trial Planned Initial Feasibility Endpoint, Helen M Johnson, Vicente Valero, Wei T Yang, Benjamin D Smith, Savitri Krishnamurthy, Heather Lin, Gaiane M Rauch, Henry M Kuerer

Faculty, Staff and Student Publications

Background: Response to neoadjuvant systemic therapy (NST) for breast cancer enables tailoring of subsequent therapy. Image-guided breast biopsy after NST can accurately predict a pathologic complete response (pCR). The feasibility phase of the clinical trial reported here assesses omission of breast surgery followed by radiotherapy in terms of local recurrence before trial expansion.

Study design: Women with unicentric, cT1-2 N0-1 M0 triple-negative (TNBC) or human epidermal growth factor receptor 2-positive breast cancer (HER2+BC) cancer with < 2 cm residual disease on post-NST imaging were eligible to enroll. If no residual invasive or in situ disease was identified by image-guided, vacuum-assisted core biopsy (VACB), breast surgery was omitted, and radiotherapy delivered. The primary endpoint for the feasibility phase was ipsilateral breast tumor recurrence at 6 months. If any recurrence occurred during the feasibility phase the trial would halt.

Results: Thirteen patients were enrolled from March 2017 to October 2018. The mean age was 60.8 years (range 51 to 75) and most patients were …

Venetoclax Consolidation In High-Risk Cll Treated With Ibrutinib For ≥1 Year Achieves A High Rate Of Undetectable Mrd, Philip A Thompson, Michael J Keating, Alessandra Ferrajoli, Nitin Jain, Christine B Peterson, Sa A Wang, Tapan M Kadia, Prithviraj Bose, Naveen Pemmaraju, Nicholas J Short, William G Wierda

Faculty, Staff and Student Publications

Patients receiving ibrutinib for CLL rarely achieve undetectable measurable residual disease (U-MRD), necessitating indefinite therapy, with cumulative risks of treatment discontinuation due to progression or adverse events. This study added venetoclax to ibrutinib for up to 2 years, in patients who had received ibrutinib for ≥12 months (mo) and had ≥1 high risk feature (TP53 mutation and/or deletion, ATM deletion, complex karyotype or persistently elevated β2-microglobulin). The primary endpoint was U-MRD with 10−4 sensitivity (U-MRD4) in bone marrow (BM) at 12mo. Forty-five patients were treated. On intention-to-treat analysis, 23/42 (55%) patients improved their response to CR (2 pts were …

Evolutionary Codependency: Insights Into The Mitonuclear Interaction Landscape From Experimental And Wild Caenorhabditis Nematodes, Suzanne Estes, Zachary P. Dietz, Vaishali Katju, Ulfar Bergthorsson

Biology Faculty Publications and Presentations

Aided by new technologies, the upsurgence of research into mitochondrial genome biology during the past 15 years suggests that we have misunderstood, and perhaps dramatically underestimated, the ongoing biological and evolutionary significance of our long-time symbiotic partner. While we have begun to scratch the surface of several topics, many questions regarding the nature of mutation and selection in the mitochondrial genome, and the nature of its relationship to the nuclear genome, remain unanswered. Although best known for their contributions to studies of developmental and aging biology, Caenorhabditis nematodes are increasingly recognized as excellent model systems to advance understanding in these …

Embryonic Development Of Natural Annual Killifish Populations Of The Genus Austrolebias: Evolutionary Parallelism And The Role Of Environment, Hellen Schlueb, Daniel Blanco, Daniel García, Jason Podrabsky

Biology Faculty Publications and Presentations

1. Repeated, independent emergence of the same trait within different phylogenetic lineages is termed parallel evolution. It typically occurs as a result of similar selective pressures. Annual killifish have adapted to survive in the extreme habitat of temporary pools on three continents and present an especially amenable system for studying fundamental principles of evolutionary parallelism. When the pools dry, annual killifish embryos survive through the dry phase in the bottom substrate in a stage of dormancy—a diapause. The diapause is a complex set of three different developmental stages, none of which is obligate, thus leading to a multitude of potential developmental …

Minimal Positional Substring Cover Is A Haplotype Threading Alternative To Li And Stephens Model

Faculty, Staff and Student Publications

The Li and Stephens (LS) hidden Markov model (HMM) models the process of reconstructing a haplotype as a mosaic copy of haplotypes in a reference panel. For small panels, the probabilistic parameterization of LS enables modeling the uncertainties of such mosaics. However, LS becomes inefficient when sample size is large, because of its linear time complexity. Recently the PBWT, an efficient data structure capturing the local haplotype matching among haplotypes, was proposed to offer a fast method for giving some optimal solution (Viterbi) to the LS HMM. Previously, we introduced the minimal positional substring cover (MPSC) problem as an alternative …

Establishing Effective Conservation Management Strategies For A Poorly Known Endangered Species: A Case Study Using Australia’S Night Parrot (Pezoporus Occidentalis), Nicholas P. Leseberg, Alex Kutt, Megan C. Evans, Tida Nou, Scott Spillias, Zoe Stone, Jessica C. Walsh, Stephen A. Murphy, Mike Bamford, Allan H. Burbidge, Kate Crossing, Robert A. Davis, Stephen T. Garnett, Rodney P. Kavanagh, Robert Murphy, John Read, Julian Reid, Stephen Van Leeuwen, Alexander W. T. Watson, James E. M. Watson, Martine Maron

Research outputs 2022 to 2026

An evidence-based approach to the conservation management of a species requires knowledge of that species’ status, distribution, ecology, and threats. Coupled with budgets for specific conservation strategies, this knowledge allows prioritisation of funding toward activities that maximise benefit for the species. However, many threatened species are poorly known, and determining which conservation strategies will achieve this is difficult. Such cases require approaches that allow decision-making under uncertainty. Here we used structured expert elicitation to estimate the likely benefit of potential management strategies for the Critically Endangered and, until recently, poorly known Night Parrot (Pezoporus occidentalis). Experts considered cat management the …

Jackson County Wine And Prohibition History, Unknown

Plaisance Ranch Winery Documents

In the late nineteenth century, burgeoning viticulture developments in Jackson County exhibited strong economic potential. However, early efforts to establish a wine industry in Southern Oregon were curtailed by the passage of the Volstead Act, initiating prohibition. This document provides some historical context for that period.

Letter From Joseph Ginet 02, Joseph Ginet

Plaisance Ranch Winery Documents

No abstract provided.

Mobilization Exchange Report, Jospeh Ginet

Plaisance Ranch Winery Documents

This is Joseph Ginet's official report of the mobilization exchange specification.

Maintaining Grassland Plant Diversity While Controlling Woody Plant Encroachment, James Stubbendieck, Kay L. Kottas, S. J. Tunnell, S. J. Palazzolo

IGC Proceedings (1977-2023)

The tallgrass prairie region of the United States is a fragmented grassland ecosystem. Much of the 1 to 2% of the remaining prairie is being degraded by invading woody plants, which frequently results in a shift from grassland to woodland. Smooth sumac (Rhus glabra L.), a shrub native to the region, can rapidly increase in density and become dominant in the plant community. Prescribed fire alone is not a constraint to this resprouting species (Stubbendieck et al., 2003). Herbicides are useful tools for managing woody plants in grasslands, but the negative response of desirable plants to herbicides is …

Do Species And Functional Diversity Indices Reflect Changes In Grazing Regimes And Climatic Conditions In Northeastern Spain?, F. De Bello, J. Leps, M. T. Sebastià

IGC Proceedings (1977-2023)

Understanding the mechanisms that maintain biodiversity in various ecosystems enables the development of management practices that prevent degradation (Canals & Sebastia, 2000). Each diversity index reflects some compositional properties and could be influenced differently by stress and disturbance factors (Magurran, 2004). In this study, we aim to reveal 1) which management practices and environmental factors affect biodiversity in rangelands of northeastern Spain and 2) the relationship between species diversity and functional diversity (SD and FD).

Impact Of Grazing Regimes On Mean Sward Height: Implications For The Management Of Bird Habitats In Agricultural Landscapes, M. Tichit, D. Durant, E. Kernéïs

IGC Proceedings (1977-2023)

Grazing in wet grasslands is a key process to manage foraging and nesting habitats for waders. Grazing has positive and negative effects related to the importance of sward conditions for these species and to nest-trampling by cattle. For settlement and nesting, lapwings need a short sward ( ≤ 10cm; see Durant et al., this congress). However, when lapwings settle in early spring, grasslands seldom are grazed yet, due to low soil carrying capacity. We studied the effect of autumn and winter grazing regimes on sward structure in early spring, and the effect of grazing regime in early spring on …

Soil Carbon Sequestration Under Three Years Of No-Till Forage Cropping Systems, D. H. Min, J. D. Deyoung, Richard Leep

IGC Proceedings (1977-2023)

The effects of reduced tillage on soil organic carbon (SOC) are generally well established (Chan et al., 2002; Cabardella & Elliott, 1992). The effects of different crops are also somewhat understood (Drinkwater et al., 1998). However, many of these studies are done in the laboratory to study the effects of crop residues on SOC. Many forage-based systems have very little crop residue returned to the field. What residue does return is often in the form of manure or compost, which is usually broken down much more rapidly than most crop residues. The objective of this study is to …

Number And Viability Of Seeds Recovered From Faeces Of Ruminant Animals, Alaba O. Jolaosho, Olufemi S. Onifade, O. M. Arigbede, Jimoh A. Olanite, T. O. Akinola

IGC Proceedings (1977-2023)

Ruminants play a significant role in the dissemination of plant seeds as a result of ingested seeds during grazing on pasture escaping digestion that are voided with the faeces and returned to the seed bank (Russi et al., 1992).

Population Changes Of Invasive Annuals In California Annual And Perennial Grasslands, Richard King

IGC Proceedings (1977-2023)

Some non-native annual forbs and grasses can be invasive in California's annual grassland region. Taeniatherum caput-medusae (L.) Nevski and Centaurea solstitialis L. can spread quickly, become nearly monospecific stands, and reduce carrying capacity for livestock and wildlife. Centaurea also can be toxic to horses. Lathyrus hirsutus L. is less invasive, but the seed is toxic to various livestock. Since 1991, the author has raised beef cattle on 16 ha of predominantly annual grassland where these 3 species occur, and a family member has raised cattle on approximately 40 ha of adjacent property. Surface soils in this hilly land are …

The Effect Of Sheep Grazing At Two Stocking Rates On The Seedling Recruitment Of Grassland Forbs, Johannes Isselstein, Markus Kowarschik, S. Bonn, M. Hofmann

IGC Proceedings (1977-2023)

Limitations for seedling recruitment are major constraints to maintain and enhance plant species diversity in productive grasslands (Bakker & Berendse 1999). Grass sward condition plus species-specific requirements for germination and survival determine the recruitment success. Therefore, a field experiment investigated the establishment of oversown seeds from wildflower forbs in relation to grass sward management.

Neurocomputing And Interfacing Digital Tasting System: Research, Design, And Evaluation, Amira J. Zaylaa, Ahmad El Hajj

BAU Journal - Science and Technology

The continuous evolution in computing and interfacing has been extended to develop multi-sensory experiences in many domains such as neurological, auditory, vision, and haptic domains. So far, only a few remarkable system approaches have been approved to be serving the taste sensation digitally. Although taste sensation is linked to the brain, there is a lack of optimal neurocomputing digital taste sensation systems. Our study provides a new neurocomputing method to digitally stimulate the sense of taste by electrical stimulation on the human tongue. We aim to link chemical stimulation and electrical stimulation in order to design an electronic interface for …

Chemical Composition, Antioxidant And Hemolytic Activities Of Sage (Salvia Fruticosa Miller) Cultivated In Lebanon, Sarah Karneeb, Safaa Baydoun, Hatem Nasser, Nelly Arnold-Apostolides, Mohammad H. El-Dakdouki

BAU Journal - Science and Technology

As part of the efforts contributing towards encouraging the cultivation of commercially valuable medicinal and aromatic plants and the conservation of vulnerable wild species suffering from depletion due to destructive unsustainable harvesting from the wild, we set out to assess the in vitro antioxidant activity, decipher the phytochemical profile, and evaluate the hemolytic activity of Salvia fruticosa Miller cultivated at Beirut Arab University herbal garden in Bekaa, Eastern Lebanon. The chemical compositions of the methanolic, aqueous and essential oil extracts were assessed by GC-MS analysis. In addition, the total phenolic, total flavonoid, total carbohydrate and total protein contents were determined …

A Basis For Designing Policies To Optimize Soil Carbon Sequestration In Southeastern Us Grasslands, Joel R. Brown, D. L. Faulkner

IGC Proceedings (1977-2023)

Increasing the amount of carbon (C) stored in terrestrial ecosystems is an important part of most national greenhouse gas (GHG) management strategies. Among the policy and program options available to achieve increased C sequestration, improved management of grasslands offers an attractive option to both reduce atmospheric concentrations of C and enhance environmental co-benefits (soil quality, water quality, food and fibre production, and wildlife habitat). In the United States, incentives for applying improved land management practices come primarily via federal government conservation programs administered by the United States Department of Agriculture (USDA). While private sector markets offer opportunities to increase the …

The Nature Of Sequestered Carbon In Different Irish Mineral Soils, C. M. Byrne, D. Fay, J. A. Ferreira, M. H. B. Hayes

IGC Proceedings (1977-2023)

Humic substances (HS) provide the major sinks for carbon (C) in soils. Although HS have a degree of resistance to microbial degradation, they are degraded in time. Humin, the HS component in association with the soil mineral colloids, has greatest resistance to degradation. To understand the extent to which soil can be a sink for C it is important to know the soil mineralogy, and to be aware of aspects of the structures of the humic components. Enhanced biological oxidation occurs in soils in long term cultivation. Its effects can be observed by comparing the amounts and compositions of the …

Three-Dimensional Higher-Order Compressive Sensing For Raypath Separation In An Acoustic Waveguide, Fengyan Zhong

Journal of Marine Science and Technology–Taiwan

In an acoustic waveguide, the separation of multiple raypaths, especially close raypaths, is a challenging task in the presence of colored noise due to interference in the acoustic eld. In this paper, a three-dimensional higher-order compressive sensing method for raypath separation is proposed. The method is applied on an array-to-array experimental conguration where both emitter and reception arrays are used. With the array-to-array conguration, the raypaths are characterized by three parameters including arrival direction, departure direction, and arrival time. Furthermore, the performance of the proposed algorithm is illustrated by simulations and experiments. The numerical results based on simulation illustrate that …

Projection Of Sea Surface Temperature Based On Empirical Mode Decomposition And Its Application In Typhoon Number Forecast, Wen-Cheng Huang, Jung-Chen Lee

Journal of Marine Science and Technology–Taiwan

The primary objective of this paper is to demonstrate the applicability of empirical mode decomposition (EMD) in projecting non-stationary daily sea surface temperature (SST) series, and the other is to apply the projected series of SST to estimate the number of typhoons. The study focuses on an area ranging from 5°N~25°N and 110°E~170°E, collecting daily sea temperature data and typhoons records within this region. The findings conclusively indicate that the EMD-based data generation method proposed in this paper can effectively addresses the limitations of previous hydrological models in generating non-stationary series, signifying a significant advancement in hydrological time series modeling …

Revision Of The Family Asterolecaniidae (Hemiptera: Coccomorpha) In Argentina, María C. Granara De Willink, Patricia González, Christof F. Stumpf

Insecta Mundi

The Asterolecaniidae (Hemiptera: Coccomorpha), known as pit scales, are currently represented by 11 genera and 52 species in the Neotropical region, and by five species in Argentina. The goal of this study is to review and update the information currently known about the biodiversity of Asterolecaniidae in Argentina. We describe Argenta Granara de Willink new genus, Argenta eduardoi Granara de Willink new species, Mycetococcus ligae Granara de Willink new species, and Sclerosococcus williamsi Granara de Willink new species; an illustration of Pollinia pollini (Costa) is also included; the species Asterolecanium puteanum Russell and Russellaspis pustulans (Cockerell) …