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Full-Text Articles in Life Sciences

Lingnan Gardeners Newsletter (No. 67) = 彩園通訊 (第67期), Lingnan Gardeners, Centre For Cultural Research And Development, Lingnan University Jul 2023

Lingnan Gardeners Newsletter (No. 67) = 彩園通訊 (第67期), Lingnan Gardeners, Centre For Cultural Research And Development, Lingnan University

Lingnan Gardeners Newsletter 嶺南彩園通訊

No abstract provided.


The Effects Of Temperature And Flooding Duration On The Structure And Magnitude Of A Floodplain Prey Subsidy, Ryan J. Rezek, Jordan A. Massie, James A. Nelson, Rolando O. Santos, Natasha M. Viadero, W. Ryan James, Ross E. Boucek, Jennifer S. Rehage Jul 2023

The Effects Of Temperature And Flooding Duration On The Structure And Magnitude Of A Floodplain Prey Subsidy, Ryan J. Rezek, Jordan A. Massie, James A. Nelson, Rolando O. Santos, Natasha M. Viadero, W. Ryan James, Ross E. Boucek, Jennifer S. Rehage

Marine Science

Riverine floodplains serve as an important link between terrestrial and aquatic systems, as the rising and falling of water drive spatial food web subsidies that are critical to the functioning and stability of ecosystems. As these systems are increasingly impacted by hydrological alterations and climate change, it is important to understand how floodplain spatial food web subsidies may respond to changing environmental conditions.

Here, we examine the interannual variation in the structure of a sunfish (Lepomis spp.) prey subsidy from freshwater marshes into the mangrove-lined creeks of Rookery Branch in the Florida Coastal Everglades that occurs during seasonal dry downs. …


Ocean Connectivity And Habitat Characteristics Predict Population Genetic Structure Of Seagrass In An Extreme Tropical Setting, Udhi E. Hernawan, Kor-Jent Van Dijk, Gary A. Kendrick, Ming Feng, Oliver Berry, Christopher Kavazos, Kathryn Mcmahon Jul 2023

Ocean Connectivity And Habitat Characteristics Predict Population Genetic Structure Of Seagrass In An Extreme Tropical Setting, Udhi E. Hernawan, Kor-Jent Van Dijk, Gary A. Kendrick, Ming Feng, Oliver Berry, Christopher Kavazos, Kathryn Mcmahon

Research outputs 2022 to 2026

Understanding patterns of gene flow and processes driving genetic differentiation is important for a broad range of conservation practices. In marine organisms, genetic differentiation among populations is influenced by a range of spatial, oceanographic, and environmental factors that are attributed to the seascape. The relative influences of these factors may vary in different locations and can be measured using seascape genetic approaches. Here, we applied a seascape genetic approach to populations of the seagrass, Thalassia hemprichii, at a fine spatial scale (~80 km) in the Kimberley coast, western Australia, a complex seascape with strong, multidirectional currents greatly influenced by extreme …


Spatial Patterns In Host-Associated And Free-Living Bacterial Communities Across Six Temperate Estuaries, Alessandra L. Suzzi, Michael Stat, Troy F. Gaston, Megan J. Huggett Jul 2023

Spatial Patterns In Host-Associated And Free-Living Bacterial Communities Across Six Temperate Estuaries, Alessandra L. Suzzi, Michael Stat, Troy F. Gaston, Megan J. Huggett

Research outputs 2022 to 2026

A major goal of microbial ecology is to establish the importance of spatial and environmental factors in driving community variation. Their relative importance likely varies across spatial scales, but focus has primarily been on free-living communities within well-connected aquatic environments rather than less connected island-like habitats such as estuaries, and key host-associated communities within these systems. Here we sampled both free-living (seawater and sediment) and host-associated (estuarine fish hindgut microbiome, Pelates sexlineatus) communities across six temperate Australian estuaries spanning ∼500 km. We find that spatial and environmental factors have different influences on these communities, with seawater demonstrating strong distance-decay relationships …


Characterization Of Antimicrobial Properties Of Excrement And Functional Microbiome Of Black Vultures (Coragyps Atratus), Bridgette Gray Jul 2023

Characterization Of Antimicrobial Properties Of Excrement And Functional Microbiome Of Black Vultures (Coragyps Atratus), Bridgette Gray

Theses

Black vultures, Coragyps atratus, are obligate scavenging birds that consume and dispose of decaying carcasses and carrion. They fulfill a key ecological niche in the environments in which they live. It has been observed that these vultures sometimes excrete bodily waste onto their legs. This adaptive behavior could help aid them in controlling bacteria and other microbes they encounter while stepping into a carcass to eat. This study directly examined the antimicrobial properties of the excrement of black vultures across various bacterial species utilizing a zone of inhibition test and a nematode species utilizing a survival assay. The black vulture …


Analysis Of The Paraventricular Nucleus Of The Hypothalamus After Exposure To Decabromodiphenyl Ether In Mice, Tia Blossomgame, Hermei Herman, Sharlenn La, Jocelyn Saquisili, Annabella Vargas, Grace Martinichio, Vincent P. Markowski Jul 2023

Analysis Of The Paraventricular Nucleus Of The Hypothalamus After Exposure To Decabromodiphenyl Ether In Mice, Tia Blossomgame, Hermei Herman, Sharlenn La, Jocelyn Saquisili, Annabella Vargas, Grace Martinichio, Vincent P. Markowski

McNair Scholars Program

No abstract provided.


Silver Ions Inhibit Bacterial Movement And Stall Flagellar Motor, Benjamin Russell, Ariel Rogers, Ryan Yoder, Matthew Kurilich, Venkata Rao Krishnamurthi, Jingy Chen, Yong Wang Jul 2023

Silver Ions Inhibit Bacterial Movement And Stall Flagellar Motor, Benjamin Russell, Ariel Rogers, Ryan Yoder, Matthew Kurilich, Venkata Rao Krishnamurthi, Jingy Chen, Yong Wang

Physics Faculty Publications and Presentations

Silver (Ag) in different forms has been gaining broad attention due to its antimicrobial activities and the increasing resistance of bacteria to commonly prescribed antibiotics. However, various aspects of the antimicrobial mechanism of Ag have not been understood, including how Ag affects bacterial motility, a factor intimately related to bacterial virulence. Here, we report our study on how Ag+ ions affect the motility of E. coli bacteria using swimming, tethering, and rotation assays. We observed that the bacteria slowed down dramatically by >70% when subjected to Ag+ ions, providing direct evidence that Ag+ ions inhibit the motility …


Assessing The Needs Of Utah Dairy Farmers To Inform Extension Programming, Bruce F. Richards, Lendel Narine, Justin Clawson, Kalen Taylor, Jacob Hadfield, Jody Gale Jul 2023

Assessing The Needs Of Utah Dairy Farmers To Inform Extension Programming, Bruce F. Richards, Lendel Narine, Justin Clawson, Kalen Taylor, Jacob Hadfield, Jody Gale

Outcomes and Impact Quarterly

A needs assessment was conducted by the Utah State University Dairy Extension Team to identify the most urgent issues faced by Utah dairy farmers. The assessment found that the top five priority needs were implementing new technology, improving public perception of water use, managing risk, succession planning, and reducing feed costs. The results will guide dairy Extension programming in Utah. Several workshops and events have already been planned to address these needs. Overall, the assessment will help USU Extension provide research-based educational programs to meet the needs of the dairy industry in Utah.


Spatial Distribution Of Histamine In Bed Bug-Infested Homes, Johnalyn M. Gordon, Richard G. Santangelo, Maria A. González-Morales, Mark Menechella, Coby Schal, Zachary C. Devries Jul 2023

Spatial Distribution Of Histamine In Bed Bug-Infested Homes, Johnalyn M. Gordon, Richard G. Santangelo, Maria A. González-Morales, Mark Menechella, Coby Schal, Zachary C. Devries

Entomology Faculty Publications

Histamine is a component of the bed bug aggregation pheromone. It was recently identified as an environmental contaminant in homes with active bed bug infestations, posing a potential health risk to humans via skin contact or inhalation. It remains unclear how histamine is distributed in homes and if histamine can become airborne. In the present study, histamine levels in household dust were quantified from multiple locations within bed bug infested and uninfested apartments. Bed bug population levels were quantified using both traps and visual counts. The amount of histamine detected varied significantly with respect to sampling location, with the highest …


Characterization And Estimation Of Musculoskeletal Pain Using Machine Learning, Boluwatife Faremi Jul 2023

Characterization And Estimation Of Musculoskeletal Pain Using Machine Learning, Boluwatife Faremi

Master's Theses

Traditional scales utilized for recording pain are known to be highly subjective and biased due to inaccuracies in recollecting actual pain intensities. As a result, machine learning (ML) models that are trained using these scores as ground truth are reported to have low performance for objective pain classification because of the huge disparity between what was felt in moments of pain and the scores recorded afterward.

In the present study, two devices were designed for gathering real-time, continuous in-session subjective pain scores and the recording of the autonomic nervous system (ANS) altered endodermal (EDA) activity. 24 participants were recruited to …


Orchestration Of Mirna Patterns By Testosterone And Dietary Tomato Carotenoids During Early Prostate Carcinogenesis In Tramp Mice, Lei Wan, Jennifer M Thomas-Ahner, Dennis K Pearl, John W Erdman, Nancy E Moran, Steven K Clinton Jul 2023

Orchestration Of Mirna Patterns By Testosterone And Dietary Tomato Carotenoids During Early Prostate Carcinogenesis In Tramp Mice, Lei Wan, Jennifer M Thomas-Ahner, Dennis K Pearl, John W Erdman, Nancy E Moran, Steven K Clinton

Children’s Nutrition Research Center Staff Publications

Background: The integrative effects of prostate cancer risk factors, such as diet and endocrine status, on cancer-associated miRNA expression are poorly defined.

Objectives: This study aimed to define the influence of androgens and diet (tomato and lycopene) on prostatic miRNA expression during early carcinogenesis in the transgenic adenocarcinoma of the mouse prostate (TRAMP) model.

Methods: Wild type (WT) and TRAMP mice were fed control, tomato-containing, or lycopene-containing diets from 4 to 10 weeks of age. Mice underwent either sham (intact) or castration surgery at 8 wk, and half of the castrated mice received testosterone (2.5 mg/kg body weight/d) at 9 …


Data Sharing: Putting Nature’S Policy To The Test, Xiwei Chen, Stephanie L Dickinson, Anna L M Macagno, Chelsie M Parker, David B Allison Jul 2023

Data Sharing: Putting Nature’S Policy To The Test, Xiwei Chen, Stephanie L Dickinson, Anna L M Macagno, Chelsie M Parker, David B Allison

Children’s Nutrition Research Center Staff Publications

No abstract provided.


Towards A Model Of Biliary Atresia – Pilot Feasibility Study In Newborn Piglets, Thora Wesenberg Helt, Lene Buelund, Lise Borgwardt, Thomas Eriksen, Lars Johansen, Robin De Nijs, Soren Holm, Douglas G Burrin, Thomas Thymann, Vibeke Brix Christensen Jul 2023

Towards A Model Of Biliary Atresia – Pilot Feasibility Study In Newborn Piglets, Thora Wesenberg Helt, Lene Buelund, Lise Borgwardt, Thomas Eriksen, Lars Johansen, Robin De Nijs, Soren Holm, Douglas G Burrin, Thomas Thymann, Vibeke Brix Christensen

Children’s Nutrition Research Center Staff Publications

Biliary atresia (BA) is a rare congenital liver disease with unknown etiology, and it is the most common indication for liver transplantation in children. As BA infants suffer from intestinal malabsorption and neurodevelopmental deficits, it is necessary to identify optimal medical and nutritional strategies using appropriate neonatal animal models. We aim to determine the feasibility of using newborn piglets with surgically induced cholestasis (bile duct ligation (BDL)) to mimic clinical features of BA. Six piglets were subjected to abdominal surgery on day 4 after birth. The bile ducts were ligated, and the piglet were followed for up to 12 days. …


Incorporating Metapopulation Dynamics To Inform Invasive Species Management: Evaluating Bighead And Silver Carp Control Strategies In The Illinois River, Jahn Kallis, Richard Erickson, D. P. Coulter, Alison A. Coulter, Marybeth K. Brey, Matt Catalano, John Dettmers, James Garvey, Kevin Irons, Elizabeth Marschall, Kenneth Rose, Mark Wildhaber, David Glover Jul 2023

Incorporating Metapopulation Dynamics To Inform Invasive Species Management: Evaluating Bighead And Silver Carp Control Strategies In The Illinois River, Jahn Kallis, Richard Erickson, D. P. Coulter, Alison A. Coulter, Marybeth K. Brey, Matt Catalano, John Dettmers, James Garvey, Kevin Irons, Elizabeth Marschall, Kenneth Rose, Mark Wildhaber, David Glover

Natural Resource Management Faculty Publications

1. Invasive species management can benefit from predictive models that incorporate spatially explicit demographics and dispersal to guide resource allocation decisions.
2. We used invasive bigheaded carps (Hypophthalmichthys spp.) in the Illinois River, USA as a case study to create a spatially explicit model to evaluate the allocation of future management efforts. Specifically, we compared additional harvest (e.g. near the invasion front vs. source populations) and enhanced movement deterrents to meet the management goal of reducing abundance at the invasion front.
3. We found additional harvest in lower river pools (i.e. targeting source populations) more effectively limited population sizes upriver …


Sympatric Soil Microbe Interactions Between Streptomyces And Fusarium Isolates, Lehren A. Olk-Szost Jul 2023

Sympatric Soil Microbe Interactions Between Streptomyces And Fusarium Isolates, Lehren A. Olk-Szost

All NMU Master's Theses

Interkingdom interactions between soil bacteria and fungi may play a critical role in occurrence of disease suppressive soils, yet our understanding of these interactions remains limited. Streptomyces are well-known producers of antimicrobial compounds important to medicine and agriculture. Production of these secondary metabolites is often mediated by quorum sensing. Most Streptomyces research occurs in single species experiments, yet new metabolites have been discovered in interspecies co-culture experiments. Interspecies, intergenic, and interkingdom co-culture research will likely reveal many valuable compounds, and strengthen our understanding of complex ecological interactions in soil microbiomes. Interactions between sympatric Streptomyces and Fusarium isolates from disease suppressive …


Applications Of Environmental Dna (Edna) To Detect Subterranean And Aquatic Invasive Species: A Critical Review On The Challenges And Limitations Of Edna Metabarcoding, Sakib Tahmid Rishan, Richard Kline, Md Saydur Rahman Jul 2023

Applications Of Environmental Dna (Edna) To Detect Subterranean And Aquatic Invasive Species: A Critical Review On The Challenges And Limitations Of Edna Metabarcoding, Sakib Tahmid Rishan, Richard Kline, Md Saydur Rahman

School of Earth, Environmental, & Marine Sciences Faculty Publications

The world is struggling to solve a devastating biodiversity loss that not only affects the extinction of treasured species and irreplaceable genetic variation, but also jeopardizes the food production, health, and safety of people. All initiatives aimed to conserve biodiversity rely heavily on the monitoring of both species and populations to get accurate spatial patterns and overall population assessments. Conventional monitoring techniques, such as visual surveys and counting individuals, are problematic due to challenges in identifying cryptic species or immature life stages. Environmental DNA (eDNA) is a relatively new technology that has the potential to be a faster, non-invasive, and …


Pestfacts Wa Issue 11 - July 2023, Alan Lord Jul 2023

Pestfacts Wa Issue 11 - July 2023, Alan Lord

PestFacts WA

PestFacts WA Issue 11 - July 2023 contents:

  • Native budworm activity update


Pestfacts Wa Issue 10 - July 2023, Svetlana Micic, Cindy L. Webster, Benjamin S. Congdon, Kylie Chambers Jul 2023

Pestfacts Wa Issue 10 - July 2023, Svetlana Micic, Cindy L. Webster, Benjamin S. Congdon, Kylie Chambers

PestFacts WA

PestFacts WA Issue 10 - July 2023 contents:

  • Russian wheat aphid
  • Turnip yellows virus detected in flying green peach aphids and in canola
  • Bacterial blight, Septoria avenae blotch and leaf rust are appearing in oats


The Role Of Tc-Ptp-Mediated Suppression Of Autophagy During Skin Carcinogenesis, Obed Asare Jul 2023

The Role Of Tc-Ptp-Mediated Suppression Of Autophagy During Skin Carcinogenesis, Obed Asare

Theses and Dissertations

Ultraviolet B (UVB) radiation can distort cellular homeostasis and predispose the skin to carcinogenesis. Amongst the deteriorating effects of the sun’s UVB radiation on cellular homeostasis is the formation of DNA photoproducts such as cyclobutene pyrimidine dimers. These photoproducts can cause significant changes in the structure and conformation of the DNA, inducing gene mutations which may accumulate to trigger the formation of skin cancer. Photoproducts are typically repaired by nucleotide excision repair. Notwithstanding, when the repair mechanism fails, apoptosis ensues to prevent the accumulation of mutations and to restore cellular homeostasis. We have identified T-cell protein tyrosine phosphatase (TC-PTP) as …


Biochar Reduces The Pupation And Eclosion Of A Specialist (Manduca Sexta) And A Generalist Pest (Spodoptera Frugiperda), Nischal Wagle Jul 2023

Biochar Reduces The Pupation And Eclosion Of A Specialist (Manduca Sexta) And A Generalist Pest (Spodoptera Frugiperda), Nischal Wagle

Theses and Dissertations

Chapter 1: This chapter incorporates detailed information about the biochar concept, its production, composition, and properties, harmful arthropods and their damage, the effect of soil on the arthropod community, and the application of biochar on arthropod control.

Chapter 2: The comprehensive lab experiment was conducted with modified pupation media enriched with walnut shell biochar (Chapter II) to evaluate the effects of biochar on the pupation and eclosion success rates of a specialist (Manduca sexta) and a generalist pest (Spodoptera frugiperda). We found that the biochar treatment led to a significant reduction in pupal mass, adult mass, adult wingspan, body length, …


Soil Moisture Dynamics In Cover Cropping Systems: From Local To Global Scales, Manish Gautam Jul 2023

Soil Moisture Dynamics In Cover Cropping Systems: From Local To Global Scales, Manish Gautam

Theses and Dissertations

Cover cropping systems, which have gained recognition for their ability to enhance soil health and promote sustainability are also associated with potential risks related with declining soil moisture and pose a dilemma for farmers considering the adoption of cover crops in water deficit semi-arid settings worldwide. To address this pressing issue, we conducted a participatory cover cropping trial in the Lower Rio Grande Valley (LRGV) region, encompassing four different farms and supplemented this experiment with a meta-analysis to answer our soil moisture and climate parameters and quantify the impact of cover crops on soil moisture levels. The findings revealed that …


Tamaulipan Thornforest Restoration: Factors Influencing Restoration Outcomes And Impacts Of Cover Crops During Replanting, Jerald T. Garrett Jul 2023

Tamaulipan Thornforest Restoration: Factors Influencing Restoration Outcomes And Impacts Of Cover Crops During Replanting, Jerald T. Garrett

Theses and Dissertations

Though the rate of deforestation has slowed in recent years, it remains a primary cause of land cover change within forest ecosystems. The Lower Rio Grande Valley, Texas (LRGV) has lost nearly 95% of its native thornforest since the early 1900’s due to agricultural and urban expansion. The focus of this study is to assess the current vegetative state of restored thornforest sites located in the eastern LRGV and to evaluate the use of cover crops during replanting of native seedlings. Our assessment of restored thornforest sites revealed actively restored sites demonstrated higher overall averages of richness, abundance, and diversity …


Breathing Around The Clock: Novel Circadian And Light-Driven Mechanisms That Govern Daily Breathing Behavior In Mice, Aaron Andrew Jones Jul 2023

Breathing Around The Clock: Novel Circadian And Light-Driven Mechanisms That Govern Daily Breathing Behavior In Mice, Aaron Andrew Jones

Dissertations (1934 -)

Breathing, like many physiological functions, exhibits a daily rhythm in mammals that coincides with periods of wakefulness and increased metabolic activity. Dysregulation of daily breathing rhythms has been implicated in a variety of respiratory diseases with time-specific symptomatology including sleep apnea, asthma, chronic pulmonary disease, sudden unexpected death in epilepsy, and COVID-19. While the daily rhythm in breathing is regulated by the endogenous circadian clock in the brain, the underlying physiological and cellular mechanisms modulating daily breathing behavior remain largely unknown. Light is the most potent synchronizer of the circadian system in mammals and is likely the principal driver of …


A Trait-Based Approach To Explain Plant Coexistence In Tropical Forests, Felipe Nery Arantes Mello Jul 2023

A Trait-Based Approach To Explain Plant Coexistence In Tropical Forests, Felipe Nery Arantes Mello

Dissertations (1934 -)

Ecology seeks to explain the mechanisms that allow multiple species to coexist in the same habitat without one species outcompeting or driving others to extinction. Niche differentiation is a mechanism that has been proposed to allow species to coexist through specialization on different resources or habitats, which reduces competition and the probability of competitive exclusion. Species can reduce competition by using different combinations of resources and thus partitioning available resources in time and space. Differences in resource use is hypothesized to be influenced by species’ morphological and physiological adaptations, known as functional traits. Links between functional traits and abiotic factors …


Improving Cold Tolerance Of Asian Rice Through Plant Growth Promoting Bacteria And Rice Gene Manipulation: Mechanisms Of Pseudomonas Mosselli And Osmads27, Nasim Maghboli Balasjin Jul 2023

Improving Cold Tolerance Of Asian Rice Through Plant Growth Promoting Bacteria And Rice Gene Manipulation: Mechanisms Of Pseudomonas Mosselli And Osmads27, Nasim Maghboli Balasjin

Dissertations (1934 -)

It is estimated that by the year 2050, the human population will extend to 9.7 billion and therefore the demand for food will increase. It is important to find ways to maintain production of critical crops, like rice, to match the demand. Climate change affects crop productivity as it is the reason for extreme warm or cold weather fluctuations. Asian rice (Oryza sativa L.) generally is grown in tropical and subtropical regions and thus, is sensitive to cold temperatures. This study hypothesized two strategies could improve growth and cold tolerance of rice plants: (1) use of plant growth promoting bacteria …


Skeleton Weed In Western Australia: Management Guide, Department Of Primary Industries And Regional Development, Western Australia Jul 2023

Skeleton Weed In Western Australia: Management Guide, Department Of Primary Industries And Regional Development, Western Australia

Biosecurity bulletins

Skeleton weed can reduce crop yields by competing for moisture and nutrients (mainly nitrogen). This guide helps you manage and eradicate skeleton weed infestations on your property, and helps to stop the spread across WA.

Without the coordinated program aimed at controlling the spread, skeleton weed would now be much more abundant and widely established throughout cereal growing areas.

Industry Funding Scheme (grains, seeds and hay)

The Grains, Seeds and Hay Industry Funding Scheme is overseen by a seven-member Industry Management Committee. These 2 groups are comprised of producers and others with an interest in the industry. They meet in …


Enhanced Bypass Of Pd-L1 Translation Reduces The Therapeutic Response To Mtor Kinase Inhibitors, Yanan Cao, Qing Ye, Murong Ma, Qing-Bai She Jul 2023

Enhanced Bypass Of Pd-L1 Translation Reduces The Therapeutic Response To Mtor Kinase Inhibitors, Yanan Cao, Qing Ye, Murong Ma, Qing-Bai She

Markey Cancer Center Faculty Publications

Increased PD-L1 expression in cancer cells is known to enhance immunosuppression, but the mechanism underlying PD-L1 upregulation is incompletely characterized. We show that PD-L1 expression is upregulated through internal ribosomal entry site (IRES)-mediated translation upon mTORC1 inhibition. We identify an IRES element in the PD-L1 50-UTR that permits cap-independent translation and promotes continuous production of PD-L1 protein despite effective inhibition of mTORC1. eIF4A is found to be a key PD-L1 IRES-binding protein that enhances PD-L1 IRES activity and protein production in tumor cells treated with mTOR kinase inhibitors (mTORkis). Notably, treatment with mTORkis in vivo elevates PD-L1 levels and reduces …


Integrative Analysis Of Mendelian Randomization And Gene Expression Profiles Reveals A Null Causal Relationship Between Adiponectin And Diabetic Retinopathy, Ao Zhang, Hui Wu, Chi Wang, Suyan Tian Jul 2023

Integrative Analysis Of Mendelian Randomization And Gene Expression Profiles Reveals A Null Causal Relationship Between Adiponectin And Diabetic Retinopathy, Ao Zhang, Hui Wu, Chi Wang, Suyan Tian

Markey Cancer Center Faculty Publications

Observational studies have been conducted to investigate the correlation between adiponectin and diabetic retinopathy (DR), but no consistent relationship has been established. In this study, we employed an integrative analysis that combined Mendelian randomization (MR) and bioinformatics analyses to comprehensively explore the association between DR and adiponectin, aiming to provide a unified answer of their relationship. Using the inverse-variance weighted (IVW) method, the odd ratio (OR) of developing DR per 1 mg/dL increment in genetically predicted log- transformed adiponectin concentration was estimated to be 0.949 (P = 0.557). Other robust MR methods produced consistent results, confirming the absence of a …


Lung And Colorectal Cancer Disparities In Appalachian Kentucky: Spatial Analysis On The Influence Of Education And Literacy, Nicole Robertson Mph, Todd Burus, Lauren Hudson, Pamela C. Hull, Lee Park, Nathan L. Vanderford Jul 2023

Lung And Colorectal Cancer Disparities In Appalachian Kentucky: Spatial Analysis On The Influence Of Education And Literacy, Nicole Robertson Mph, Todd Burus, Lauren Hudson, Pamela C. Hull, Lee Park, Nathan L. Vanderford

Markey Cancer Center Faculty Publications

Low educational attainment and high cancer incidence and mortality rates have long been a challenge in Appalachian Kentucky. Prior studies have reported disparities in cancer incidence and mortality between Appalachian and non-Appalachian populations, but the influence of education on this disparity has not been extensively studied. Herein, all cancers and two cancer sites with available screenings (colorectal and lung) were joined with education indicators (educational attainment and literacy) and one geographic indicator across all 120 Kentucky counties. This dataset was used to build choropleth maps and perform simple linear and spatial regression to assess statistical significance and to measure the …


Messes: Software For Transforming Messy Research Datasets Into Clean Submissions To Metabolomics Workbench For Public Sharing, P. Travis Thompson, Hunter N. B. Moseley Jul 2023

Messes: Software For Transforming Messy Research Datasets Into Clean Submissions To Metabolomics Workbench For Public Sharing, P. Travis Thompson, Hunter N. B. Moseley

Markey Cancer Center Faculty Publications

In recent years, the FAIR guiding principles and the broader concept of open science has grown in importance in academic research, especially as funding entities have aggressively promoted public sharing of research products. Key to public research sharing is deposition of datasets into online data repositories, but it can be a chore to transform messy unstructured data into the forms required by these repositories. To help generate Metabolomics Workbench depositions, we have developed the MESSES (Metadata from Experimental SpreadSheets Extraction System) software package, implemented in the Python 3 programming language and supported on Linux, Windows, and Mac operating systems. MESSES …