Life Sciences Commons^™

A Phase 1/2 Study Of Azacitidine, Venetoclax And Pevonedistat In Newly Diagnosed Secondary Aml And In Mds Or Cmml After Failure Of Hypomethylating Agents, Nicholas J Short, Muharrem Muftuoglu, Faustine Ong, Lewis Nasr, Walid Macaron, Yesid Alvarado, Naval Daver, Courtney D Dinardo, Gautam Borthakur, Nitin Jain, Maro Ohanian, Elias Jabbour, Ghayas C Issa, Wei Qiao, Xuelin Huang, Rashmi Kanagal-Shamanna, Keyur P Patel, Prithviraj Bose, Farhad Ravandi, Ricardo Delumpa, Regina Abramova, Guillermo Garcia-Manero, Michael Andreeff, Jorge Cortes, Hagop Kantarjian

Faculty, Staff and Student Publications

BACKGROUND: Pevonedistat is a first-in-class, small molecular inhibitor of NEDD8-activating enzyme that has clinical activity in acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS). Preclinical data suggest synergy of pevonedistat with azacitidine and venetoclax.

METHODS: This single-center, phase 1/2 study evaluated the combination of azacitidine, venetoclax and pevonedistat in older adults with newly diagnosed secondary AML or with MDS or chronic myelomonocytic leukemia (CMML) after failure of hypomethylating agents. Patients received azacitidine 75 mg/m

FINDINGS: Forty patients were enrolled (32 with AML and 8 with MDS/CMML). In the AML cohort, the median age was 74 years (range 61-86 years), and …

A Phase 1/2 Study Of Azacitidine, Venetoclax And Pevonedistat In Newly Diagnosed Secondary Aml And In Mds Or Cmmlafter Failure Of Hypomethylating Agents, Nicholas J Short, Muharrem Muftuoglu, Faustine Ong, Lewis Nasr, Walid Macaron, Yesid Alvarado, Naval Daver, Courtney D Dinardo, Gautam Borthakur, Nitin Jain, Maro Ohanian, Elias Jabbour, Ghayas C Issa, Wei Qiao, Xuelin Huang, Rashmi Kanagal-Shamanna, Keyur P Patel, Prithviraj Bose, Farhad Ravandi, Ricardo Delumpa, Regina Abramova, Guillermo Garcia-Manero, Michael Andreeff, Jorge Cortes, Hagop Kantarjian

Faculty, Staff and Student Publications

BACKGROUND: Pevonedistat is a first-in-class, small molecular inhibitor of NEDD8-activating enzyme that has clinical activity in acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS). Preclinical data suggest synergy of pevonedistat with azacitidine and venetoclax.

METHODS: This single-center, phase 1/2 study evaluated the combination of azacitidine, venetoclax and pevonedistat in older adults with newly diagnosed secondary AML or with MDS or chronic myelomonocytic leukemia (CMML) after failure of hypomethylating agents. Patients received azacitidine 75 mg/m

FINDINGS: Forty patients were enrolled (32 with AML and 8 with MDS/CMML). In the AML cohort, the median age was 74 years (range 61-86 years), and …

Effects Of Feeding A Vitamin And Mineral Supplement To Cow-Calf Pairs Grazing Native Range, Jennifer L. Hurlbert, Friederike Baumgaertner, Kacie L. Mccathy, Timothy Long, Cody Wieland, Kevin K. Sedivec, Carl R. Dahlen

Department of Animal Science: Faculty Publications

Our objectives were to evaluate the impacts of providing vitamin and mineral (VTM) supplements to cow-calf pairs during the summer grazing period on cow and calf performance and liver concentrations of minerals. During a two-year period, 727 crossbred cows and their calves (initial cow BW = 601.7 ± 48.1 kg; calf BW = 87.8 ± 5.0 kg; n = 381 in year 1, n = 346 in year 2) from the Central Grasslands Research Extension Center (Streeter, N.D.) were blocked by parity (young [parity 1 to 3], and old [parity 4+]) and randomly assigned to pastures at the beginning …

Molecular Identification Of Oomycete Species Associated With Woody Plants In Louisiana And Survey Of Oomycete Species Associated With Live Oak Trees Planted On The Louisiana State University Campus, Hamilton Crockett

LSU Master's Theses

Three Oomycetes genera, Phytophthora, Phytopythium and Pythium, contain many important plant pathogens. Historically, Phytophthora infestans, responsible for the great Irish potato famine, and Phytophthora ramorum, causal agent of sudden oak death disease, are the two better-known high impact pathogens. The LSU AgCenter Plant Diagnostic Center (PDC) has been isolating putative Phytophthora and related species from combined root and soil samples collected from various woody ornamentals and trees for over a decade. In August of 2016, Louisiana received torrential rains, which resulted in historic flooding in several southern parishes. During subsequent years, the PDC staff isolated a …

Relationships Between Running Biomechanics And Femoral Articular Cartilage Thickness And Composition In Anterior Cruciate Ligament Reconstruction Patients, Hyunwook Lee

Theses and Dissertations

Background: Patients with anterior cruciate ligament reconstruction (ACLR) have demonstrated morphological and compositional changes in femoral articular cartilage. However, it is unclear how running biomechanics are associated with femoral cartilage thickness and composition for both ACLR patients and controls. Objectives: (1) to compare measures of femoral cartilage thickness and composition between ACLR patients and matched non-ACLR controls at resting, (2) to investigate how 30 minutes of running influences the aforementioned measures for ACLR patients and controls, and (3) to investigate relationships between running biomechanics and knee cartilage thickness and composition in ACLR patients and controls. Methods: Twenty ACLR patients (age: …

The Evolution Of Transposable Elements As Cis-Regulatory Elements In Mammals, Alan Y. Du

Arts & Sciences Graduate Student Theses and Dissertations

Transposable elements (TEs) are mobile genetic elements that make up a large proportion of mammalian genomes. Although TEs are highly prevalent genomic sequences, they have been understudied as they were once labeled as “junk DNA.” Despite their initial status as simple genomic parasites, recent studies have implicated TEs as cis-regulatory elements, supplying promoters, enhancers, and boundary elements. Functional testing of regulatory activity, however, remains a significant bottleneck. Nonetheless, due to their repetitive nature, TEs provide a unique model to examine the evolution of cis-regulatory elements, which has traditionally been difficult to study due to lack of homology at the sequence …

Evaluation Of A Nutritional Calming Supplement For Stress Management In Beef Cattle, Randall Mallette

LSU Master's Theses

Two studies were conducted to determine the efficacy of two formulations of a nutritional calming product, Placid 1.0 and Placid 2.0, at keeping beef cattle in a calm state when exposed to environmental factors that put them into an excited state. In the pilot study, nine crossbred beef heifers were orally drenched daily for three days with 60 mL of their respective treatments, pen scores and exit scores were recorded, and blood was collected for cortisol analysis. There were no treatment effects for either treatment on any of the measured behavioral parameters or serum cortisol concentrations.

The products were …

Mitophagy Promotes Resistance To Bh3 Mimetics In Acute Myeloid Leukemia, Christina Glytsou, Xufeng Chen, Emmanouil Zacharioudakis, Wafa Al-Santli, Hua Zhou, Soobeom Lee, Zhengxi Sun, Dimitrios Papaioannou, Michael Cammer, Kun Wang, Tomasz Zal, Malgorzata Anna Zal, Bing Z Carter, Jo Ishizawa, Raoul Tibes, Aristotelis Tsirigos, Michael Andreeff, Evripidis Gavathiotis, Iannis Aifantis

Faculty, Staff and Student Publications

BH3 mimetics are used as an efficient strategy to induce cell death in several blood malignancies, including acute myeloid leukemia (AML). Venetoclax, a potent BCL-2 antagonist, is used clinically in combination with hypomethylating agents for the treatment of AML. Moreover, MCL1 or dual BCL-2/BCL-xL antagonists are under investigation. Yet, resistance to single or combinatorial BH3-mimetic therapies eventually ensues. Integration of multiple genome-wide CRISPR/Cas9 screens revealed that loss of mitophagy modulators sensitizes AML cells to various BH3 mimetics targeting different BCL-2 family members. One such regulator is MFN2, whose protein levels positively correlate with drug resistance in patients with AML. MFN2 …

Comutations And Krasg12c Inhibitor Efficacy In Advanced Nsclc, Marcelo V Negrao, Haniel A Araujo, Giuseppe Lamberti, Alissa J Cooper, Neal S Akhave, Lukas Delasos, Mihaela Aldea, Gabriele Minuti, Jacobi Hines, Jacqueline V Aredo, Michael J Dennis, Turja Chakrabarti, Susan C Scott, Paolo Bironzo, Matthias Scheffler, Petros Christopoulos, Albrecht Stenzinger, Jonathan W Riess, So Yeon Kim, Sarah B Goldberg, Mingjia Li, Qi Wang, Yun Qing, Ying Ni, Minh Truong Do, Richard Lee, Biagio Ricciuti, Joao Victor Alessi, Jing Wang, Blerina Resuli, Lorenza Landi, Shu-Chi Tseng, Mizuki Nishino, Subba R Digumarthy, Waree Rinsurongkawong, Vadeerat Rinsurongkawong, Ara A Vaporciyan, George R Blumenschein, Jianjun Zhang, Dwight H Owen, Collin M Blakely, Giannis Mountzios, Catherine A Shu, Christine M Bestvina, Marina Chiara Garassino, Kristen A Marrone, Jhanelle E Gray, Sandip Pravin Patel, Amy L Cummings, Heather A Wakelee, Juergen Wolf, Giorgio Vittorio Scagliotti, Federico Cappuzzo, Fabrice Barlesi, Pradnya D Patil, Leylah Drusbosky, Don L Gibbons, Funda Meric-Bernstam, J Jack Lee, John V Heymach, David S Hong, Rebecca S Heist, Mark M Awad, Ferdinandos Skoulidis

Faculty, Staff and Student Publications

Molecular modifiers of KRASG12C inhibitor (KRASG12Ci) efficacy in advanced KRASG12C-mutant NSCLC are poorly defined. In a large unbiased clinicogenomic analysis of 424 patients with non-small cell lung cancer (NSCLC), we identified and validated coalterations in KEAP1, SMARCA4, and CDKN2A as major independent determinants of inferior clinical outcomes with KRASG12Ci monotherapy. Collectively, comutations in these three tumor suppressor genes segregated patients into distinct prognostic subgroups and captured ∼50% of those with early disease progression (progression-free survival ≤3 months) with KRASG12Ci. Pathway-level integration of less prevalent coalterations in functionally related genes nominated PI3K/AKT/MTOR pathway and additional baseline RAS gene alterations, including amplifications, …

Mas And Mans Predicts Repeated Sprint Ability In Youth Soccer Players, Jørgen D. Olsen, Henrik R. Rognhaug, Daniel Kvamme, Øyvind Støren, Eva Maria Støa

International Journal of Exercise Science

International Journal of Exercise Science 16(6): 846-854, 2023. The study investigated the impact of maximal aerobic speed (MAS) and maximal anaerobic sprint (MANS) on repeated sprint ability (RSA) in soccer. Methods: 17 amateur-to semi-professional soccer players, age 19 (± 4) years, were tested for maximal oxygen consumption (VO_2max), oxygen cost of running (C_r), RSA consisting of 15×20m sprint each divided by a 100 seconds dribble track, and 40-meter sprint performance. MAS was calculated as VO_2max × C_r ⁻¹, and MANS was defined as the highest velocity in the 40-meter sprint. Results: There was …

Carbon Fiber Insoles Enhance Perception Of Performance Despite Variable Objective Outcomes: Specific To The Moderately Active Individual, Erin E. Dierickx, Cody R. Butler, Robert A. Huggins, Emma Zuk, Lea C. Mason, Lindsay J. Distefano, Douglas J. Casa

International Journal of Exercise Science

International Journal of Exercise Science 16(4): 885-897, 2023. Carbon fiber insoles (CFIs) may benefit performance in elite athletes, however, their use in moderately active individuals has been adopted without evidence supporting such enhancements in this population. Fifteen male subjects performed vertical jump (VJ) and repeat treadmill sprint tests before and after a VO_2peak while wearing 1) CFIs and 2) control insoles (CON). Subjects completed a subjective survey regarding their perceived performance abilities for both conditions. There were no significant differences between CFIs and CON in VJ height, sprint distance, heart rate following sprints; and rate of oxygen consumption, perceived …

Body Composition (Dxa) And Maximal Strength Of Powerlifters: A Descriptive Quantitative And Longitudinal Study, Pierre-Marc Ferland, Jérémie Charron, Mathieu Brisebois-Boies, Fanie St-Jean Miron, Alain Steve Comtois Phd

International Journal of Exercise Science

International Journal of Exercise Science 16(4): 828-845, 2023. The purpose of this study was to present the relationships between maximal strength and body composition and to conduct yearly follow-ups presenting the chronic effects of maximal strength training on body composition. Thirty-four (age = 28.8 ± 8.7 yrs) classic powerlifters (M = 21; F = 13) completed at least one Dual-Energy X-Ray Absorptiometry (DXA) 43.97 ± 23.93 days after a sanctioned international powerlifting federation affiliate competition (Squat + Bench Press + Deadlift = Total (kg)). In addition, thirteen subjects (n = 13) completed at least one yearly follow up. Paired …

The Acute Effect Of Tissue Flossing On Pain, Function, And Perception Of Movement, Christopher Kelly, Zachary Oliveri, Joseph Saladino, Joseph Senatore, Amy Kamat, Jordan Zarour, Peter C. Douris

International Journal of Exercise Science

International Journal of Exercise Science 16(3): 855-865, 2023. Tissue flossing (TF) is a novel device that has been shown to cause peripheral compression and concurrent change in joint range of motion, perception of mobility and muscular performance. However, the effect of tissue flossing on pain, perception of mobility and function at the elbow joint has not been thoroughly investigated. The purpose of this pilot study was to examine the acute effect of TF on pain and upper extremity functional performance in subjects with musculoskeletal-related complaints of pain surrounding the elbow joint. We utilized a randomized crossover design. Nine resistance trained …

The Impact Of The Cold Pressor Test On Inter-Arm Differences In Blood Pressure, Alyssa C. Watts, Lauren A. Naylor, Michael E. Holmstrup, Brock T. Jensen

International Journal of Exercise Science

International Journal of Exercise Science 16(2): 875-884, 2023. A large inter-arm difference (IAD+; ≥10mmHg between arms at rest) in blood pressure (BP) at rest is linked to cardiovascular risk, and exercise can change this difference. As mechanisms for IAD are elusive, unique physiological stimuli may provide insight towards a better understanding of this phenomenon. The cold pressor test (CPT) has a potent effect on BP and acts primarily through sympathetic nervous system (SNS) stimulation, though the effects of SNS stimulation on IAD are unknown. Therefore, the purpose of the present study was to examine the effects of the CPT on …

Effects Of Different Surfaces On Metabolic Cost During Repetitive Jumping: A Pilot Study, Scott Lyons, Kyle Reason, Danilo Tolusso, Ariel Weddle

International Journal of Exercise Science

International Journal of Exercise Science 16(2): 866-874, 2023. The purpose of this pilot study was to determine if there is a difference in metabolic cost when jumping on platforms of varying thickness, as well as whether a difference exists in metabolic cost between genders exists on the different platforms. Fourteen participants (seven males and seven females) completed three repetitive jumping trials on the DigiJump machine. Each trial was performed at a cadence of 120 jumps per minute and at a minimum height of 1/2” per jump. Trials were completed on platforms of 1/2”, 3/8”, and 1/4” thickness. Participants were instructed …

Strength Training: An Inquiry Of Females Perceptions, Laura A. Richardson, Victoria R. Kanel, Alexandria L. Rellinger, Susan E. Ramlo, Carrie L. Fister

Topics in Exercise Science and Kinesiology

Topics in Exercise Science and Kinesiology Volume 4: Issue 1, Article 10, 2023. While traditionally considered a male-dominated activity, women have increasingly embraced strength training. Although strength training has numerous physical and mental benefits to women, their subjective decision-making about using strength training have not been investigated thoroughly, especially using a unique methodology, Q, that is designed specifically to study subjectivity such as viewpoints and decision-making. There is limited research focused on females’ viewpoints about strength training. Capturing feelings and perceptions females have towards resistance training in an objective manner requires a specialized, mixed method called Q methodology [Q] that …

Specialized Late Cingulo-Opercular Network Activation Elucidates The Mechanisms Underlying Decisions About Ambiguity, Jordan E. Pierce, Nathan M. Petro, Elizabeth Clancy, Caterina Gratton, Steven E. Petersen, Maital Neta

Center for Brain, Biology, and Behavior: Faculty Publications

Cortical task control networks, including the cingulo-opercular (CO) network play a key role in decision-making across a variety of functional domains. In particular, the CO network functions in a performance reporting capacity that supports successful task performance, especially in response to errors and ambiguity. In two studies testing the contribution of the CO network to ambiguity processing, we presented a valence bias task in which masked clearly and ambiguously valenced emotional expressions were slowly revealed over several seconds. This slow reveal task design provides a window into the decision-making mechanisms as they unfold over the course of a trial. In …

Controlling Soil Erosion After Wildfire And Guiding Recovery In Southern Utah, Kristina Young, Kara Dohrenwend, Matt Mcettrick, Henry Grover

All Current Publications

Wildfire is a natural part of many ecosystems in the Four Corners region (Southern Utah, Northern Arizona, Southwest Colorado, and Northwest New Mexico). However, after decades of fire suppression, the intensity and size of wildfires is increasing. This fact sheet is intended to help those in dry, monsoonal regions understand what happens to land after a wildfire and explains the processes of soil erosion. It outlines factors that influence how wildfire can affect soils and plants and provides suggestions for reducing soil erosion when necessary. The information presented is relevant to both private landowners and public lands managers whose landscapes …

The Timid Invasion: Behavioural Adjustments And Range Expansion In A Non-Native Rodent, Jana A. Eccard, Valeria Mazza, Celia Holland, Peter Stuart

Publications

Animal behaviour can moderate biological invasion processes, and the native fauna's ability to adapt. The importance and nature of behavioural traits favouring colonization success remain debated. We investigated behavioural responses associated with risk-taking and exploration, both in non-native bank voles (Myodes glareolus, N = 225) accidentally introduced to Ireland a century ago, and in native wood mice (Apodemus sylvaticus, N = 189), that decline in numbers with vole expansion. We repeatedly sampled behavioural responses in three colonization zones: established bank vole populations for greater than 80 years (2 sites), expansion edge vole populations present for 1–4 …

Ticks And Tick-Borne Pathogens From Wild Pigs In Northern And Central Florida, Sarah E. Mays Maestas, Lindsay P. Campbell, Michael P. Milleson, Lawrence E. Reeves, Phillip E. Kaufman, Samantha M. Wisely

School of Integrative Biological & Chemical Sciences Faculty Publications

Simple Summary

Ticks are vectors of several agents of human disease, and improvements to traditional surveillance methods are needed to aid in tick-borne disease monitoring and prevention. Invasive wild pigs are broadly distributed in the southern U.S., and removal efforts are often undertaken by local, state, and federal entities. Wild pigs are hosts to several human-biting tick species associated with agents of human disease. This research examines the use of tick collection from wild pigs in the state of Florida as a method of surveillance for ticks and tick-borne pathogens of human concern. Four species of human-biting ticks were collected …

Interactive Effects Of The Partial Pressure Of Co2, Temperature, And Nutrient-Limitation On The Physiology And Growth Of The Coccolithophore E. Huxleyi Grown On A 12:12 L:D Cycle Of Illumination, James Bradley

LSU Master's Theses

I studied the interactive effects of pCO2, temperature, and nutrient limitation on the growth and physiology of the marine coccolithophore, Emiliania huxleyi. This was done to look at the effect of climate change factors on the widespread and abundant calcifying marine organism as a predictor of what the future has to hold. The strain of E. huxleyi (PnB 272 B10) was grown on a 12:12 L:D cycle of illumination and exposed to either high or low pCO2 under nutrient-replete or nitrate-limited conditions across a temperature range of 10–28C. I examined the direct and interactive effects of temperature, pCO2, and nutrient …

Evaluating Approaches For Constructing Polygenic Risk Scores For Prostate Cancer In Men Of African And European Ancestry, Burcu F Darst, Jiayi Shen, Ravi K Madduri, Alexis A Rodriguez, Yukai Xiao, Edward J Saunders, Mark N Brook, Thomas J Hoffmann, Kenneth Muir, Peggy Wan, Loic Le Marchand, Lynne Wilkens, Ying Wang, Johanna Schleutker, Robert J Macinnis, Cezary Cybulski, David E Neal, Børge G Nordestgaard, Sune F Nielsen, Jyotsna Batra, Judith A Clements, Australian Prostate Cancer Bioresource, Henrik Grönberg, Nora Pashayan, Ruth C Travis, Jong Y Park, Demetrius Albanes, Stephanie Weinstein, Lorelei A Mucci, David J Hunter, Kathryn L Penney, Catherine M Tangen, Robert J Hamilton, Marie-Élise Parent, Janet L Stanford, Stella Koutros, Alicja Wolk, Karina D Sørensen, William J Blot, Edward D Yeboah, James E Mensah, Yong-Jie Lu, Daniel J Schaid, Stephen N Thibodeau, Catharine M West, Christiane Maier, Adam S Kibel, Géraldine Cancel-Tassin, Florence Menegaux, Esther M John, Eli Marie Grindedal, Kay-Tee Khaw, Sue A Ingles, Ana Vega, Barry S Rosenstein, Manuel R Teixeira, Nc-La Pcap Investigators, Manolis Kogevinas, Lisa Cannon-Albright, Chad Huff, Luc Multigner, Radka Kaneva, Robin J Leach, Hermann Brenner, Ann W Hsing, Rick A Kittles, Adam B Murphy, Christopher J Logothetis, Susan L Neuhausen, William B Isaacs, Barbara Nemesure, Anselm J Hennis, John Carpten, Hardev Pandha, Kim De Ruyck, Jianfeng Xu, Azad Razack, Soo-Hwang Teo, Canary Pass Investigators, Lisa F Newcomb, Jay H Fowke, Christine Neslund-Dudas, Benjamin A Rybicki, Marija Gamulin, Nawaid Usmani, Frank Claessens, Manuela Gago-Dominguez, Jose Esteban Castelao, Paul A Townsend, Dana C Crawford, Gyorgy Petrovics, Graham Casey, Monique J Roobol, Jennifer F Hu, Sonja I Berndt, Stephen K Van Den Eeden, Douglas F Easton, Stephen J Chanock, Michael B Cook, Fredrik Wiklund, John S Witte, Rosalind A Eeles, Zsofia Kote-Jarai, Stephen Watya, John M Gaziano, Amy C Justice, David V Conti, Christopher A Haiman

Faculty, Staff and Student Publications

Genome-wide polygenic risk scores (GW-PRSs) have been reported to have better predictive ability than PRSs based on genome-wide significance thresholds across numerous traits. We compared the predictive ability of several GW-PRS approaches to a recently developed PRS of 269 established prostate cancer-risk variants from multi-ancestry GWASs and fine-mapping studies (PRS269). GW-PRS models were trained with a large and diverse prostate cancer GWAS of 107,247 cases and 127,006 controls that we previously used to develop the multi-ancestry PRS269. Resulting models were independently tested in 1,586 cases and 1,047 controls of African ancestry from the California Uganda Study and 8,046 cases and …

Changes In Outcomes And Factors Associated With Survival In Melanoma Patients With Brain Metastases, Merve Hasanov, Denái R Milton, Alicia Bea Davies, Elizabeth Sirmans, Chantal Saberian, Sylvia Opusunju, Carlos A Torres-Cabala, Elizabeth M Burton, Rivka R Colen, Jason T Huse, Isabella C Glitza Oliva, Caroline Chung, Mary Frances Mcaleer, Susan L Mcgovern, Debra N Yeboa, Betty Y S Kim, Sujit S Prabhu, Ian E Mccutcheon, Jeffrey S Weinberg, Frederick F Lang, Hussein A Tawbi, Jing Li, Lauren E Haydu, Michael A Davies, Sherise D Ferguson

Faculty, Staff and Student Publications

BACKGROUND: Treatment options for patients with melanoma brain metastasis (MBM) have changed significantly in the last decade. Few studies have evaluated changes in outcomes and factors associated with survival in MBM patients over time. The aim of this study is to evaluate changes in clinical features and overall survival (OS) for MBM patients.

METHODS: Patients diagnosed with MBMs from 1/1/2009 to 12/31/2013 (Prior Era; PE) and 1/1/2014 to 12/31/2018 (Current Era; CE) at The University of Texas MD Anderson Cancer Center were included in this retrospective analysis. The primary outcome measure was OS. Log-rank test assessed differences between groups; multivariable …

A Functional Link Between Lariat Debranching Enzyme And The Intron-Binding Complex Is Defective In Non-Photosensitive Trichothiodystrophy, Brittany A Townley, Luke Buerer, Ning Tsao, Albino Bacolla, Fadhel Mansoori, Nathanial Clark, Nicolas Schmidt, Sridhar Nonavinkere Srivatsan, Hua Sun, Reilly A Sample, Joshua R Brickner, Drew Mcdonald, Miaw-Sheue Tsai, Matthew J Walter, David F Wozniak, Alex S Holehouse, Vladimir Pena, John A Tainer, William G Fairbrother, Nima Mosammaparast

Faculty, Staff and Student Publications

The pre-mRNA life cycle requires intron processing; yet, how intron-processing defects influence splicing and gene expression is unclear. Here, we find that TTDN1/MPLKIP, which is encoded by a gene implicated in non-photosensitive trichothiodystrophy (NP-TTD), functionally links intron lariat processing to spliceosomal function. The conserved TTDN1 C-terminal region directly binds lariat debranching enzyme DBR1, whereas its N-terminal intrinsically disordered region (IDR) binds the intron-binding complex (IBC). TTDN1 loss, or a mutated IDR, causes significant intron lariat accumulation, as well as splicing and gene expression defects, mirroring phenotypes observed in NP-TTD patient cells. A Ttdn1-deficient mouse model recapitulates intron-processing defects and certain …

The Role Of Using Images In Outdoor Advertising Designs To Attract Attention, Sattar Al-Juboori

Outdoor advertising has dominated the visual landscape of cities around the world. Outdoor advertising in city streets and public places are different than the ones located in other places for many reasons. First, it is directed towards particular audience who has no option but to look at it. The research problem lies in the excessive use of images in ways that may have been randomly put without taking into consideration certain factors such as allocation, processing, design construction or some expressive and psychological aspects. Experts have defined some technical problems related to image-choice and the extent of its future impact …

Professional And Ethical Challenges Of Robot Journalism From The Perspective Of Jordanian Journalists, Mazen Al-Fedawi

This study aimed at identifying the extent of Jordanian journalists ’awareness of the concept of robot journalism and its mechanisms of action, and identifying the most important areas covered by robot journalism, in addition to reviewing the pros and cons of the spread of robot journalism, and the most important professional and ethical challenges associated with robot journalism from the viewpoint of Jordanian journalists. To achieve the objectives of the study, the researcher followed the descriptive and analytical method. The study sample consisted of (350) Jordanian journalists, and the questionnaire was distributed to them in two ways, electronically and manually. …

The Influence Of The Celebrities Of Social Media Platforms On University Students, Hanan Al-Shiekh, Mahmoud Al-Rajabi

This study aims to identify the impact of famous people on social media platforms on university students. The qualitative methodology and inductive approach were used in the research by conducting in-depth interviews with 21 students from various Jordanian universities, and a focus group of 7 university students was selected, with 12 female influencers and 21 male influencers among them. The study showed that there are seven main reasons that motivate students to pursue and follow-up those influencers, which are: admiration and love, living in another world with different influences, career path, and the release of students’ stress, gaining information that …

The Effect Of The Production Pattern On The Media Content In The Jordanian Tv Channels From The Contact Person Point View (An Analytical Study), Ashraf Al-Manaseer, Shadi Abo-Rashed

The effect of the production pattern on the media content in the Jordanian TV channels from the contact person point view, through analytical study. The study relied on the descriptive approach based on studying the facts about the nature of the phenomenon or a group of individuals, or a group of events or situations related to photographing, analyzing and evaluating the characteristics of the phenomenon to find out the variables that cause the phenomenon to occur, A questionnaire was designed for the study to achieve the desired goals, the study population consisted of 13 private channels in Jordan, and the …

The Degree Of Satisfaction Of Facebook Users About Its Features, Usage Motives And Achieved Gratifications.“An Applied Study On Students Of The Faculty Of Mass Communication At The Middle East University”To Attract Attention, Ahmad Oreqat

This study aimed at determining the extent of satisfaction of Facebook users from the students of the Faculty of Media at the Middle East University with regard to its advantages, drivers of use, and the achieved gratifications. The study sample, which was chosen on the available random sample basis, consisted of 106 students enrolled in the second semester in the 2019-2020 academic year which are 308 students. The theoretical framework of the study depended on the theory of uses and gratifications, and the results of the study highlighted that the degree of satisfaction of Facebook users among students about its …

The Impact Of Road Crossings On Karst Headwater Streams In Northwest Arkansas, Anthony M. Zenga

ATU Theses and Dissertations 2021 - Present

The karst region of NW Arkansas is home to many headwater endemic Species of Greatest Conservation Need (SGCN). This includes many species of darters, such as Etheostoma cragini, E. microperca, and E. mihileze, as well as crayfish such as Faxonious meeki brevis and F. nana. NW Arkansas is rapidly urbanizing, increasing the need to construct structures like culverts, bridges, and fords. These man-made road crossings can cause stream habitat degradation and fragmentation, as well as impair overall stream connectivity. To evaluate the impact that road crossings have on aquatic SGCN species and their habitat, 30 headwater streams were sampled throughout …