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Full-Text Articles in Life Sciences

Reimagining Large River Management Using The Resist–Accept–Direct (Rad) Framework In The Upper Mississippi River, Nicole K. Ward, Abigail J. Lynch, Erik A. Beever, Joshua Booker, Kristen L. Bouska, Holly Embke, Jeffrey N. Houser, John F. Kocik, David J. Lawrence, Mary Grace Lemon, Doug Limpinsel, Madeline R. Magee, Bryan M. Maitland, Owen Mckenna, Andrew Meier, John M. Morton, Jeffrey D. Muehlbauer, Robert Newman, Devon C. Oliver, Heidi M. Rantala, Greg G. Sass, Aaron Shultz, Laura M. Thompson, Jennifer L. Wilkening Oct 2023

Reimagining Large River Management Using The Resist–Accept–Direct (Rad) Framework In The Upper Mississippi River, Nicole K. Ward, Abigail J. Lynch, Erik A. Beever, Joshua Booker, Kristen L. Bouska, Holly Embke, Jeffrey N. Houser, John F. Kocik, David J. Lawrence, Mary Grace Lemon, Doug Limpinsel, Madeline R. Magee, Bryan M. Maitland, Owen Mckenna, Andrew Meier, John M. Morton, Jeffrey D. Muehlbauer, Robert Newman, Devon C. Oliver, Heidi M. Rantala, Greg G. Sass, Aaron Shultz, Laura M. Thompson, Jennifer L. Wilkening

Biology Faculty Publications

Background Large-river decision-makers are charged with maintaining diverse ecosystem services through unprecedented social-ecological transformations as climate change and other global stressors intensify. The interconnected, dendritic habitats of rivers, which often demarcate jurisdictional boundaries, generate complex management challenges. Here, we explore how the Resist–Accept–Direct (RAD) framework may enhance large-river management by promoting coordinated and deliberate responses to social-ecological trajectories of change. The RAD framework identifies the full decision space of potential management approaches, wherein managers may resist change to maintain historical conditions, accept change toward different conditions, or direct change to a specified future with novel conditions. In the Upper Mississippi …


The Effects Of A High-Carbohydrate Versus A High-Fat Shake On Biomarkers Of Metabolism And Glycemic Control When Used To Interrupt A 38-Hour Fast: A Randomized Crossover Study, Landon S. Deru Oct 2023

The Effects Of A High-Carbohydrate Versus A High-Fat Shake On Biomarkers Of Metabolism And Glycemic Control When Used To Interrupt A 38-Hour Fast: A Randomized Crossover Study, Landon S. Deru

Theses and Dissertations

Purpose: The primary aim of this study was to determine the impact of various fast-interrupting shakes on markers of glycemic control including glucose, β-hydroxybutyrate (BHB), insulin, glucagon, GLP-1, and GIP. Methods: Twenty-seven adults (12 female, 15 male) completed all three conditions of this study. One condition consisted of a 38-hour water-only fast, and the other two conditions were similar but the fasts were interrupted at 24 hours by either a high carbohydrate/low fat (HC/LF) or a low carbohydrate/high fat (LC/HF) shake. Results: The water only fast resulted in 135.3% more BHB compared to the HC/LF condition (t = 7.77, p < 0.0001) and 69.6% more compared to the LC/HF condition (t = 5.12, p < 0.0001). Conversely, the LC/HF condition exhibited a 38.8% higher BHB level than the HC/LF condition (t = 2.70, p = 0.0086). Additionally, the area under the curve (AUC) for glucose was 14.2% higher in the HC/LF condition than in the water condition (t = 6.23, p < 0.0001) and 6.9% higher compared to the LC/HF condition (t = 3.14, p = 0.0024), with the LC/HF condition yielding 7.8% more glucose than the water condition (t = 3.21, p = 0.0020). At the 25-hour mark, insulin and glucose-dependent insulinotropic polypeptide (GIP) were significantly elevated in the HC/LF condition compared to the LC/HF condition (F = 3.84, p = 0.0002 and F = 2.27, p = 0.0244, respectively) and compared to the water condition (F = 7.00, p < 0.0001 and F = 9.96, p < 0.0001, respectively). Furthermore, insulin, glucagon-like peptide-1 (GLP-1), and GIP were increased in the LC/HF condition compared to the water condition at 25 hours (F = 3.19, p = 0.0016, F = 2.43, p = 0.0158, and F = 12.13, p < 0.0001, respectively). Notably, glucagon concentrations at the 25-hour mark decreased in the HC/LF group compared to the LC/HF condition (F = 3.37, p = 0.0009). However, by the 38-hour time point, no statistically significant differences were observed among the conditions for any of the analyzed hormones. Conclusions: While a LC/HF shake does not mimic a fast completely, it does preserve some of the metabolic changes including elevated BHB and glucagon, and decreased glucose and insulin compared to a HC/LF shake.


A Classical Fall Statistics Problem, Timothy Meyer Oct 2023

A Classical Fall Statistics Problem, Timothy Meyer

Cornhusker Economics

An evaluation of traditional baseball measures and suggestions for alternatives, centering on statistics related to the offensive quality of a player.


Analysis And Prediction Of Liver Volume Change Maps Derived From Computational Tomography Scans Acquired Pre- And Post-Radiation Therapy, Guillaume Cazoulat, Aashish C Gupta, Mais M Al Taie, Eugene J Koay, Kristy K Brock Oct 2023

Analysis And Prediction Of Liver Volume Change Maps Derived From Computational Tomography Scans Acquired Pre- And Post-Radiation Therapy, Guillaume Cazoulat, Aashish C Gupta, Mais M Al Taie, Eugene J Koay, Kristy K Brock

Faculty, Staff and Student Publications

External beam radiation therapy (EBRT) of liver cancers can cause local liver atrophy as a result of tissue damage or hypertrophy as a result of liver regeneration. Predicting those volumetric changes would enable new strategies for liver function preservation during treatment planning. However, understanding of the spatial dose/volume relationship is still limited. This study leverages the use of deep learning-based segmentation and biomechanical deformable image registration (DIR) to analyze and predict this relationship. Pre- and Post-EBRT imaging data were collected for 100 patients treated for hepatocellular carcinomas, cholangiocarcinoma or CRC with intensity-modulated radiotherapy (IMRT) with prescription doses ranging from 50 …


Index Of Consciousness Monitoring During General Anesthesia May Effectively Enhance Rehabilitation In Elderly Patients Undergoing Laparoscopic Urological Surgery: A Randomized Controlled Clinical Trial, Fengling Qi, Long Fan, Chunxiu Wang, Yang Liu, Shuyi Yang, Fangfang Miao, Kunpeng Feng, Tianlong Wang Oct 2023

Index Of Consciousness Monitoring During General Anesthesia May Effectively Enhance Rehabilitation In Elderly Patients Undergoing Laparoscopic Urological Surgery: A Randomized Controlled Clinical Trial, Fengling Qi, Long Fan, Chunxiu Wang, Yang Liu, Shuyi Yang, Fangfang Miao, Kunpeng Feng, Tianlong Wang

Faculty, Staff and Student Publications

Background: Based on electroencephalogram (EEG) analysis, index of consciousness (IoC) monitoring is a new technique for monitoring anesthesia depth. IoC is divided into IoC1 (depth of sedation) and IoC2 (depth of analgesia). The potential for concurrent monitoring of IoC1 and IoC2 to expedite postoperative convalescence remains to be elucidated. We investigated whether combined monitoring of IoC1 and IoC2 can effectively enhances postoperative recovery compared with bispectral index (BIS) in elderly patients undergoing laparoscopic urological surgery under general anesthesia.

Methods: In this prospective, controlled, double-blinded trail, 120 patients aged 65 years or older were arbitrarily assigned to either the IoC group …


Detection Of Early Myocardial Dysfunction By Imaging Biomarkers In Cancer Patients Undergoing Photon Beam Vs Proton Beam Radiotherapy: A Prospective Study, Muhannad Aboud Abbasi, Giulia Bruno, Cristina Di Stefano, Laura Garcia Bello, Nadia N Laack, Thomas J Whitaker, Robert W Mutter, Hector R Villarraga Oct 2023

Detection Of Early Myocardial Dysfunction By Imaging Biomarkers In Cancer Patients Undergoing Photon Beam Vs Proton Beam Radiotherapy: A Prospective Study, Muhannad Aboud Abbasi, Giulia Bruno, Cristina Di Stefano, Laura Garcia Bello, Nadia N Laack, Thomas J Whitaker, Robert W Mutter, Hector R Villarraga

Faculty, Staff and Student Publications

1. Background: We sought to determine acute and subacute changes in cardiac function after proton beam (PBT) and photon beam (PhT) radiotherapy (RT) using conventional and two-dimensional speckle tracking echocardiography (2D-STE) in patients with malignant breast and thoracic tumors. 2. Methods: Between March 2016 and March 2017, 70 patients with breast or thoracic cancer were prospectively enrolled and underwent transthoracic echocardiography with comprehensive strain analysis at pretreatment, mid-treatment, end of treatment, and 3 months after RT. 3. Results: PBT was used to treat 44 patients; PhT 26 patients. Mean ± SD age was 55 ± 12 years; most patients (93%) …


Gut Microbiota Aggravates Neutrophil Extracellular Traps-Induced Pancreatic Injury In Hypertriglyceridemic Pancreatitis, Guanqun Li, Liwei Liu, Tianqi Lu, Yuhang Sui, Can Zhang, Tao Zhang, Peng Xiao, Zhongjie Zhao, Chundong Cheng, Jisheng Hu, Hongze Chen, Dongbo Xue, Hua Chen, Gang Wang, Rui Kong, Hongtao Tan, Xuewei Bai, Zhibo Li, Florencia Mcallister, Le Li, Bei Sun Oct 2023

Gut Microbiota Aggravates Neutrophil Extracellular Traps-Induced Pancreatic Injury In Hypertriglyceridemic Pancreatitis, Guanqun Li, Liwei Liu, Tianqi Lu, Yuhang Sui, Can Zhang, Tao Zhang, Peng Xiao, Zhongjie Zhao, Chundong Cheng, Jisheng Hu, Hongze Chen, Dongbo Xue, Hua Chen, Gang Wang, Rui Kong, Hongtao Tan, Xuewei Bai, Zhibo Li, Florencia Mcallister, Le Li, Bei Sun

Faculty, Staff and Student Publications

Hypertriglyceridemic pancreatitis (HTGP) is featured by higher incidence of complications and poor clinical outcomes. Gut microbiota dysbiosis is associated with pancreatic injury in HTGP and the mechanism remains unclear. Here, we observe lower diversity of gut microbiota and absence of beneficial bacteria in HTGP patients. In a fecal microbiota transplantation mouse model, the colonization of gut microbiota from HTGP patients recruits neutrophils and increases neutrophil extracellular traps (NETs) formation that exacerbates pancreatic injury and systemic inflammation. We find that decreased abundance of Bacteroides uniformis in gut microbiota impairs taurine production and increases IL-17 release in colon that triggers NETs formation. …


Global Impact Of Proteoglycan Science On Human Diseases, Christopher Xie, Liliana Schaefer, Renato V. Iozzo Oct 2023

Global Impact Of Proteoglycan Science On Human Diseases, Christopher Xie, Liliana Schaefer, Renato V. Iozzo

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

In this comprehensive review, we will dissect the impact of research on proteoglycans focusing on recent developments involved in their synthesis, degradation, and interactions, while critically assessing their usefulness in various biological processes. The emerging roles of proteoglycans in global infections, specifically the SARS-CoV-2 pandemic, and their rising functions in regenerative medicine and biomaterial science have significantly affected our current view of proteoglycans and related compounds. The roles of proteoglycans in cancer biology and their potential use as a next-generation protein-based adjuvant therapy to combat cancer is also emerging as a constructive and potentially beneficial therapeutic strategy. We will discuss …


Smart Sounding Table Using Adaptive Neuro-Fuzzy Inference System, Osman Ünal, Nuri Akkaş Oct 2023

Smart Sounding Table Using Adaptive Neuro-Fuzzy Inference System, Osman Ünal, Nuri Akkaş

Journal of Marine Science and Technology–Taiwan

Marine engineers measure the liquid level (sounding depth) to calculate the volumetric content of a ship's tank. The sounding depth is determined using an ullage pipe located at specific points on the tanks. To estimate the accurate volume of liquid, considering the ship's trim and heel conditions, engineers use a tank table (sounding table) consisting of hundreds of pages. However, this method is time-consuming and lacks intermediate values for sounding depth, trim, and heel. Ship designers recommend to use linear interpolation for intermediate values, yet this process is also time-consuming. This paper proposes the implementation of an Adaptive Neuro-Fuzzy Inference …


Case Study Of Coastal Erosion And Measures At Kezailiao Coast, Taiwan, Tai-Wen Hsu, Yi-Tse Tu, Jen-Yi Chang Oct 2023

Case Study Of Coastal Erosion And Measures At Kezailiao Coast, Taiwan, Tai-Wen Hsu, Yi-Tse Tu, Jen-Yi Chang

Journal of Marine Science and Technology–Taiwan

This paper examines major factors of coastal erosion and measures against beach erosion at Kezailiao Coast, Taiwan. Typical examples of coastal erosion due to natural or man-made factors are reviewed. Case studies of countermeasure for beach erosion are addressed. We further analyze and discuss historical shoreline and coastal cliff recession as a result of the attack of storm surges and waves. The coastline mainly made up of cliffs (2-3m high), made of soft, easily eroded boulder sand and clay. In total, 3km of land have been lost since 1951, including villages and farm buildings. The most important impacts of beach …


Wearable Sensor-Based Walkability Assessment At Ferry Terminal Using Machine Learning: A Case Study Of Mokpo, Korea, Jungyeon Choi, Hwayoung Kim Oct 2023

Wearable Sensor-Based Walkability Assessment At Ferry Terminal Using Machine Learning: A Case Study Of Mokpo, Korea, Jungyeon Choi, Hwayoung Kim

Journal of Marine Science and Technology–Taiwan

Walkability assessments are becoming more popular, as walking offers numerous health, environmental, and economic benefits to communities. However, previous studies on ferry terminal walkability assessment have been inadequate. This study aimed to develop a wearable sensor system to automatically assess walkability at ferry terminals without conducting surveys. We applied seven machine learning (ML) classifiers to detect different walking environments, including flat ground (FG), downhill slope (DS), uphill slope (US), and uneven surface (UE). The ML models were evaluated across different combinations of classes: 2-class (FG vs. UE), 3-class (U) (FG vs. US vs. UE), 3-class (D) (FG vs. DS vs. …


Application Of Blockchain Technology In Aquaculture Management, Yu-Jen Pan, Hsin-Pei Shieh Oct 2023

Application Of Blockchain Technology In Aquaculture Management, Yu-Jen Pan, Hsin-Pei Shieh

Journal of Marine Science and Technology–Taiwan

In recent years, food safety has become a growing concern in Taiwanese society. To ensure efficient management of the supply chain within the L Aquatic Products company, it is imperative to employ reliable technical support in establishing an effective traceability management system. The traceability of products can provide managers with valuable insight into the intricacies of the supply chain. By establishing a dependable food traceability system, brand trust can be strengthened, and consumers can inquire about the movement of aquatic products within the supply chain. Blockchain technology offers features such as traceability, accountability, transparency, reliability, trust, privacy, and security, making …


Production Of Ground Granulated Blast-Furnace Slag Cement: Energy And Carbon Reduction Efficiency Of Cement-Grinding System, Kuan-Hung Lin, Chung-Chia Yang Oct 2023

Production Of Ground Granulated Blast-Furnace Slag Cement: Energy And Carbon Reduction Efficiency Of Cement-Grinding System, Kuan-Hung Lin, Chung-Chia Yang

Journal of Marine Science and Technology–Taiwan

This study used clinker, ground granulated blast-furnace slag (GGBS), and gypsum in a cement-grinding system to produce GGBS cement (GCE). Gypsum was used as the alkaline activator to modify the surface area of GCE and increase its compressive strength. The results revealed that the use of the gypsum activator and the modification of the surface area of GCE effectively increased the formerly inadequate compressive strength of GCE (GGBS > 60%) in the early stage. In addition, energy consumption data were obtained during the production of GCE and Portland cement (PCE) by the cement-grinding system. The calculations concerning the production proportions indicated …


Climate-Ready Landscape Plants: Garden Roses Trialed At Reduced Irrigation Frequency In Utah, Usa, Ji-Jhong Chen, Youping Sun, Lorence R. Oki, Jared A. Sisneroz, Karrie Reid, Lloyd L. Nackley, Ryan N. Contreras, Soo-Hyung Kim, Ursula K. Schuch, Darren L. Haver, Miro Stuke, Allison Fron, Kelly Kopp, Scott B. Jones, Lawrence Hipps Oct 2023

Climate-Ready Landscape Plants: Garden Roses Trialed At Reduced Irrigation Frequency In Utah, Usa, Ji-Jhong Chen, Youping Sun, Lorence R. Oki, Jared A. Sisneroz, Karrie Reid, Lloyd L. Nackley, Ryan N. Contreras, Soo-Hyung Kim, Ursula K. Schuch, Darren L. Haver, Miro Stuke, Allison Fron, Kelly Kopp, Scott B. Jones, Lawrence Hipps

Plants, Soils, and Climate Faculty Publications

Increased urban and suburban populations in the arid western United States have resulted in more water demand; however, water availability in the region has become limited because of inadequate precipitation. Recent droughts have led to restrictions on irrigating landscape plants. Garden rose (Rosa ×hybrida) is commonly used as flowering plants in residential landscapes, but its drought tolerance has not been widely studied. The objective of this study was to determine the impact of reduced irrigation frequency on visual quality, plant growth, and physiology of five garden rose cultivars, including ChewPatout (Oso Easy® Urban Legend®), …


Supplemental Nutrition Assistance Program (Snap), Palak Gupta, Carson Johnson Oct 2023

Supplemental Nutrition Assistance Program (Snap), Palak Gupta, Carson Johnson

All Current Publications

This fact sheet from the Hunger Solutions Institute at Utah State University outlines the Supplemental Nutrition Assistance Program, otherwise known as SNAP. It addresses who qualifies and how to apply for benefits and access more information about associated programs, such as Double Up Food Bucks and Create Better Health.


Deleterious Mutations Predicted In The Sorghum (Sorghum Bicolor) Maturity (Ma) And Dwarf (Dw) Genes From Whole‑Genome Resequencing, Nathan P. Grant, John J. Toy, Deanna L. Funnell, Scott E. Sattler Oct 2023

Deleterious Mutations Predicted In The Sorghum (Sorghum Bicolor) Maturity (Ma) And Dwarf (Dw) Genes From Whole‑Genome Resequencing, Nathan P. Grant, John J. Toy, Deanna L. Funnell, Scott E. Sattler

Department of Agronomy and Horticulture: Faculty Publications

In sorghum [Sorghum bicolor (L.) Moench] the Maturity (Ma1, Ma2, Ma3, Ma4, Ma5, Ma6) and Dwarf (Dw1, Dw2, Dw3, Dw4) loci, encode genes controlling flowering time and plant height, respectively, which are critical for designing sorghum ideotypes for a maturity timeframe and a harvest method. Publicly available whole-genome resequencing data from 860 sorghum accessions was analyzed in silico to identify genomic variants at 8 of these loci (Ma1, Ma2, Ma3, Ma5, Ma6, Dw1, Dw2, Dw3) to identify novel loss …


Women, Infants, And Children (Wic), Palak Gupta, Carson Johnson Oct 2023

Women, Infants, And Children (Wic), Palak Gupta, Carson Johnson

All Current Publications

This fact sheet from the Hunger Solutions Institute at Utah State University outlines the Utah Women, Infants, and Children program known as WIC. It addresses who qualifies, the benefits, and how to access more information.


Food Assistance Programs For Seniors (60+), Palak Gupta, Carson Johnson Oct 2023

Food Assistance Programs For Seniors (60+), Palak Gupta, Carson Johnson

All Current Publications

This fact sheet from the Hunger Solutions Institute at Utah State University outlines the various food assistance programs for seniors ages 60 and over, such as the Commodity Supplemental Food Program (CSFP) and Meals on Wheels, among others. It addresses who qualifies and how to access more information.


Characterizing The Utility Of A Near Infrared Click Beetle Luciferase For Bli Applications, Giovanni Duca Oct 2023

Characterizing The Utility Of A Near Infrared Click Beetle Luciferase For Bli Applications, Giovanni Duca

Master's Theses

Bioluminescent imaging systems (BLI) have become a valuable tool for doing real-time in vivo studies. BLI systems typically allow for the imaging of surface and subsurface level tissues but as depth increases, the resolution decreases while the signal to noise ratio increases. Deep tissue imaging is therefore a major limitation for BLI. To address this limitation there has been a consistent movement in luciferase research to create long wavelength emitting luciferases that still have a high photon emission rate. Longer wavelengths of light are able to penetrate deeper tissues due to having a lower amount of absorbance and scattering from …


Larson2023_Slow Release Of Ga3_Data, Alexandra J.S. Larson, Maureen Cartwright, Whitney D. Jones, Katrina Luce, Mei Chen, Kate Petersen, Shannon V. Nelson, David J. Michaelis, Matthew D. Madsen Oct 2023

Larson2023_Slow Release Of Ga3_Data, Alexandra J.S. Larson, Maureen Cartwright, Whitney D. Jones, Katrina Luce, Mei Chen, Kate Petersen, Shannon V. Nelson, David J. Michaelis, Matthew D. Madsen

ScholarsArchive Data

This file contains the data description for the Larson2023_Slow-release of GA3 Hormone… Supplementary File.

The excel file contains four worksheets: 1) Palmer’s germination, 2) Palmer’s biomass, 3) germination other species, 4) biomass other species. Blank cells indicate either no coating was used or there was no plant.

1) “Palmer’s germination” and “germination other species” A) Temp (o C): germination chamber temperature setting B) Species: common name of penstemon species tested (“germination other species” only) C) Treatment: seed coating treatment D) Final Germination percentage: percent of seed that germinated. E) FGP: final germination percent in decimal form F) Time to 50% …


Privacy-Preserving Federated Genome-Wide Association Studies Via Dynamic Sampling, Xiaoqian Jiang, Jaideep Vaidya Oct 2023

Privacy-Preserving Federated Genome-Wide Association Studies Via Dynamic Sampling, Xiaoqian Jiang, Jaideep Vaidya

Faculty, Staff and Student Publications

MOTIVATION: Genome-wide association studies (GWAS) benefit from the increasing availability of genomic data and cross-institution collaborations. However, sharing data across institutional boundaries jeopardizes medical data confidentiality and patient privacy. While modern cryptographic techniques provide formal secure guarantees, the substantial communication and computational overheads hinder the practical application of large-scale collaborative GWAS.

RESULTS: This work introduces an efficient framework for conducting collaborative GWAS on distributed datasets, maintaining data privacy without compromising the accuracy of the results. We propose a novel two-step strategy aimed at reducing communication and computational overheads, and we employ iterative and sampling techniques to ensure accurate results. We …


Food Assistance Programs For Children, Palak Gupta, Carson Johnson Oct 2023

Food Assistance Programs For Children, Palak Gupta, Carson Johnson

All Current Publications

This fact sheet from the Hunger Solutions Institute at Utah State University outlines the various food assistance programs for children, such as the School Breakfast Program and the School Lunch Program, among others. It addresses who qualifies and how to access more information.


Quality Of Life In Male Breast Cancer: Prospective Study Of The International Male Breast Cancer Program (Eortc10085/Tbcrc029/Big2-07/Nabcg), Carolien P Schröder, Elise Van Leeuwen-Stok, Fatima Cardoso, Barbro Linderholm, Coralie Poncet, Vesna Bjelic-Radisic, Miguel H Abreu, Ivana Bozovic-Spasojevic, Irma Den Hoed, Aafke H Honkoop, Maartje Los, Jose P Leone, Nicola S Russell, Tineke J Smilde, Annette W G Van Der Velden, Catherine Van Poznak, Marije M Vleugel, Rachel L Yung, Corneel Coens, Sharon H Giordano, Kathryn J Ruddy Oct 2023

Quality Of Life In Male Breast Cancer: Prospective Study Of The International Male Breast Cancer Program (Eortc10085/Tbcrc029/Big2-07/Nabcg), Carolien P Schröder, Elise Van Leeuwen-Stok, Fatima Cardoso, Barbro Linderholm, Coralie Poncet, Vesna Bjelic-Radisic, Miguel H Abreu, Ivana Bozovic-Spasojevic, Irma Den Hoed, Aafke H Honkoop, Maartje Los, Jose P Leone, Nicola S Russell, Tineke J Smilde, Annette W G Van Der Velden, Catherine Van Poznak, Marije M Vleugel, Rachel L Yung, Corneel Coens, Sharon H Giordano, Kathryn J Ruddy

Faculty, Staff and Student Publications

INTRODUCTION: Prospective data about quality of life (QoL) in men with breast cancer (BC) are lacking. A prospective registry (EORTC10085) of men with all BC stages, including a QoL correlative study, was performed as part of the International Male Breast Cancer Program.

METHODS: Questionnaires at BC diagnosis included the EORTC QLQ-C30 and BR23 (BC specific module), adapted for men. High functioning and global health/QoL scores indicate high functioning levels/high QoL; high symptom-focused measures scores indicate high symptoms/problems levels. EORTC reference data for healthy men and women with BC were used for comparisons.

RESULTS: Of 422 men consenting to participate, 363 …


High-Level Ceftazidime/Avibactam Resistance In Escherichia Coli Conferred By The Novel Plasmid-Mediated Β-Lactamase Cmy-185 Variant, William C Shropshire, Bradley T Endres, Jovan Borjan, Samuel L Aitken, William C Bachman, Chin-Ting Wu, Ayesha Khan, William R Miller, Micah M Bhatti, Pranoti Saharasbhojane, Akito Kawai, Ryan K Shields, Samuel A Shelburne, Yohei Doi Oct 2023

High-Level Ceftazidime/Avibactam Resistance In Escherichia Coli Conferred By The Novel Plasmid-Mediated Β-Lactamase Cmy-185 Variant, William C Shropshire, Bradley T Endres, Jovan Borjan, Samuel L Aitken, William C Bachman, Chin-Ting Wu, Ayesha Khan, William R Miller, Micah M Bhatti, Pranoti Saharasbhojane, Akito Kawai, Ryan K Shields, Samuel A Shelburne, Yohei Doi

Faculty, Staff and Student Publications

OBJECTIVES: To characterize a blaCMY variant associated with ceftazidime/avibactam resistance from a serially collected Escherichia coli isolate.

METHODS: A patient with an intra-abdominal infection due to recurrent E. coli was treated with ceftazidime/avibactam. On Day 48 of ceftazidime/avibactam therapy, E. coli with a ceftazidime/avibactam MIC of >256 mg/L was identified from abdominal drainage. Illumina and Oxford Nanopore Technologies WGS was performed on serial isolates to identify potential resistance mechanisms. Site-directed mutants of CMY β-lactamase were constructed to identify amino acid residues responsible for ceftazidime/avibactam resistance.

RESULTS: WGS revealed that all three isolates were E. coli ST410. The ceftazidime/avibactam-resistant strain uniquely …


An Update On Strategies To Deliver Protein And Peptide Drugs To The Eye, Sai H S Boddu, Devarshi Acharya, Vivek Hala, Harshil Jani, Sonal Pande, Moyad Shahwan, Ketan M Ranch Oct 2023

An Update On Strategies To Deliver Protein And Peptide Drugs To The Eye, Sai H S Boddu, Devarshi Acharya, Vivek Hala, Harshil Jani, Sonal Pande, Moyad Shahwan, Ketan M Ranch

Faculty, Staff and Student Publications

In the past few decades, advancements in protein engineering, biotechnology, and structural biochemistry have resulted in the discovery of various techniques that enhanced the production yield of proteins, targetability, circulating half-life, product purity, and functionality of proteins and peptides. As a result, the utilization of proteins and peptides has increased in the treatment of many conditions, including ocular diseases. Ocular delivery of large molecules poses several challenges due to their high molecular weight, hydrophilicity, unstable nature, and poor permeation through cellular and enzymatic barriers. The use of novel strategies for delivering protein and peptides such as glycoengineering, PEGylation, Fc-fusion, chitosan …


The Effects Of Accessory Blood Flow Restriction Training On Muscle Size And Strength In Division Iii Soccer Athletes: A Preliminary Ecological Study, Kaitlyn Judd, Christian Morales, Megan White, Kate Wilkie, Justin Faller, Stephen Ives Oct 2023

The Effects Of Accessory Blood Flow Restriction Training On Muscle Size And Strength In Division Iii Soccer Athletes: A Preliminary Ecological Study, Kaitlyn Judd, Christian Morales, Megan White, Kate Wilkie, Justin Faller, Stephen Ives

International Journal of Exercise Science

International Journal of Exercise Science 16(6): 1244-1256, 2023. Blood flow restriction training (BFRT) uses occlusion during low-intensity resistance training (< 50% of 1-repetition maximum, 1RM) to reduce arterial blood flow and venous return, imposing greater metabolic stress but similar muscular hypertrophy and strength gains as high-intensity resistance training (HIRT). However, no study, to date, has incorporated BFRT in a collegiate strength and conditioning setting to assess ecological validity. We aimed to investigate the effects of adding 6-weeks of accessory BFRT or HIRT to NCAA Division III soccer players prescribed resistance training regimen on muscle strength and size. Male and female (n = 17) athletes were randomly assigned to complete biceps curls 2x/week under BFRT or control (HIRT), following regularly scheduled strength training. Bicep strength (1RM) and circumference (BC) were assessed at weeks 0, 3, and 6 (men only). In men, for BC no significant interaction of condition x time was observed (p = 0.861), though condition (BFRT vs Control, p = 0.025) and time (p = 0.024) were significant. For 1RM, there was no significant interaction of condition …


Sex Differences And Physical Activity Status On The Hamstring: Quadriceps Ratio, Activities Of Daily Living, And Functional Movement In Older Adults, Brittany N. Followay, Haley A. Reierson, Emily M. Rigden Oct 2023

Sex Differences And Physical Activity Status On The Hamstring: Quadriceps Ratio, Activities Of Daily Living, And Functional Movement In Older Adults, Brittany N. Followay, Haley A. Reierson, Emily M. Rigden

International Journal of Exercise Science

International Journal of Exercise Science 16(4): 1228-1243, 2023. The study aimed to investigate sex differences and the effect of physical activity on the hamstring:quadriceps (H:Q) ratio, activities of daily living (ADLs), and the Functional Movement Screen (FMS) in older adults. Thirty older adults (72.56 + 6.22) completed maximal voluntary isometric contractions (MVICs), ADLs, the FMS, and three closed-kinetic chain exercises (CKCs); front lunge (FL), side lunge (SL), and bilateral squat (BLSQ). Electromyography was recorded from the biceps femoris (BF) and vastus lateralis (VL) on the dominant and non-dominant limbs during the MVICs …


Are Self-Selected Intervals As Effective As Fixed Intervals In Controlling Acute Responses In High-Intensity Interval Resistance Training?, Andressa Fidalgo, Paulo Farinatti, Humberto Miranda, Lenifran Matos-Santos, Jeffrey Willardson, Walace Monteiro Oct 2023

Are Self-Selected Intervals As Effective As Fixed Intervals In Controlling Acute Responses In High-Intensity Interval Resistance Training?, Andressa Fidalgo, Paulo Farinatti, Humberto Miranda, Lenifran Matos-Santos, Jeffrey Willardson, Walace Monteiro

International Journal of Exercise Science

International Journal of Exercise Science 16(4): 1205-1215, 2023. Physical conditioning programs often apply high-intensity resistance training (HIRT), but there is a lack of research investigating the effects of using fixed or self-selected resting intervals between exercises on the performance, relative intensity, and affective perception during this modality of training. This study compared fixed versus self-selected rest intervals in HIRT sessions on cardiorespiratory responses, number of repetitions, and enjoyment perception in trained young men. Sixteen trained males (27.1 ± 3.9 years; 56.6 ± 7.5 mL.kg-1.min-1) performed HIRT circuits with 30-s and self-selected recovery interval. The duration of …


The Relationship Between Physical Mobility And Firefighter Occupational Task Performance., Shelby Harbison, Bridget F. Melton, Nicholas Hunt, Benjamin Adams, Nancy Henderson, Richard Westrick Oct 2023

The Relationship Between Physical Mobility And Firefighter Occupational Task Performance., Shelby Harbison, Bridget F. Melton, Nicholas Hunt, Benjamin Adams, Nancy Henderson, Richard Westrick

International Journal of Exercise Science

International Journal of Exercise Science 16(3): 1216-1227, 2023. Firefighters work in a dangerous profession with high injury rates. Mobility dysfunction in firefighters may impact performance and contribute to injury. The Functional Movement Screen (FMS) is commonly used to evaluate individuals for mobility dysfunction and compensatory movements. The purpose of this study was to identify if mobility is related to firefighters' occupational task performance. This was a retrospective study assessing 29 career firefighters using FMS and occupational performance task scores. Statistical analyses consisted of a multiple linear regression assessing predictors on occupational task performance, and 21 point-biserial correlations ran to assess …


A Multi-Modal Imaging Analysis Of Inter-Community Hub Nodes In Subjective Cognitive Decline Linking Longitudinal Hub Function Disruption To White Matter Integrity Kurtosis, Duncan Nowling Oct 2023

A Multi-Modal Imaging Analysis Of Inter-Community Hub Nodes In Subjective Cognitive Decline Linking Longitudinal Hub Function Disruption To White Matter Integrity Kurtosis, Duncan Nowling

MUSC Theses and Dissertations

Subjective Cognitive Decline (SCD) has garnered much interest as a potential identifiable preclinical stage and indicator of risk for cognitive decline in Alzheimer’s Disease and related dementias (ADRD). Identification of individuals in this stage though is difficult, as they present with objectively normal cognitive evaluation scores, relying instead upon self-report of concern about decline in cognitive abilities. The use of non-invasive in-vivo imaging methods like BOLD functional imaging and diffusion tensor have allowed for complex mapping of both the functional and structural network features unique to this condition. This study furthers this network biomarker map of SCD by investigating the …