Life Sciences Commons^™

Targeting Bcl6 Transcription Factor In Ovarian Cancer, Allison F. Mackey

Honors Theses and Capstones

Ovarian cancer is the most fatal female reproductive cancer, with most cases being diagnosed in late stages, after metastasis has become widespread. This can make ovarian cancer challenging to successfully treat, especially with its high rate of recurrence. The use of small molecule compounds to inhibit overexpressed transcription factors may provide an effective method for treatment. BCL6 is a transcription factor that is abnormally overexpressed in patients with recurring and late-stage ovarian cancer and has been implicated in proliferation and metastatic behavior. The identification of multiple potential inhibitors of BCL6 could improve chances for the further testing of these compounds, …

Investigating The Roles Of Plants, Fungi, And Biocrusts In Nutrient Movement Within Dryland Ecosystems, Catherine E. Cort

Open Access Theses & Dissertations

In dryland ecosystems, plant productivity and microbial decomposition are often separated in space and time due to the asynchronous availability of soil moisture and organic matter inputs. It has been proposed that fungi play a key functional role in connecting these cycles by facilitating movement of water, carbon (C), and nitrogen (N) through a network of shared hyphae between plant roots and biological soil crust (biocrust) communities at the soil surface. This connection, also known as the â??fungal loop,â?? effectively re-couples processes of nutrient release and uptake between primary producers and minimizes ecosystem N losses due to leaching, erosion, and …

Agricultural Groundcover Update December 2023, Justin Laycock

Natural resources published reports

Summary

• About 96% of the grainbelt had adequate vegetative groundcover (more than 50%) to prevent wind erosion in December 2023.
• In the northern half of the grainbelt, a larger-than-average area has 51–60% groundcover, which is expected to decrease to below 50% over the summer.
• Just under 4% of the grainbelt (553,000 ha) had less than 50% groundcover, which is inadequate to prevent wind erosion. West Midlands Ag Soil Zone had the highest risk of wind erosion and 11.4% of this farmland had inadequate groundcover.
• Less than 0.5% of the grainbelt had a high to very high risk of wind erosion …

Carbon Neutral By 2030 - Katanning Research Station, Department Of Primary Industries And Regional Development, Western Australia

Climate Science Published Reports

The Department of Primary Industries and Regional Development's (DPIRD) Katanning Research Station (KRS) is developing practical techniques and methods for mitigating carbon emissions from the livestock industry.

This research will help the livestock industry in Western Australia (WA) access anticipated future markets for carbon neutral food and fibre products.

Dna Barcoding Reveals A New Population Of The Threatened Atlantic Forest Frog Sphaenorhynchus Canga, Diego J. Santana, Andre Yves, Elvis A. Pereira, Priscila S. Carvalho, Lucio M. C. Lima, Henrique C. Costa, Don Shepard

Biological Sciences Faculty Publications and Presentations

Species identification plays a significant role in biodiversity conservation. As many species remain unrecognized, particularly in neotropical hotspots like the Brazilian Atlantic Forest (AF), novel molecular techniques are being widely employed to bridge this gap. In this study, we used DNA barcoding and phylogenetic tools to identify a new population of Sphaenorynchus canga in the central region of the Brazilian AF. Our results extend the species’ known distribution by approximately 200 km to the south, encompassing a different mountain range than its type locality (Serra do Espinhaço). This disjunct distribution, while not uncommon among amphibians, suggests a historical connection between …

A Scoping Review Of Population Diversity In The Common Genomic Aberrations Of Clear Cell Renal Cell Carcinoma, Sean S. Kumar, Ninad Khandekar, Komal Dani, Saina R. Bhatt, Vinay Duddalwar, Anishka D'Souza

Department of Medicine Faculty Publications

Introduction: Previous literature has shown that clear cell renal cell carcinoma (ccRCC) is becoming a more prevalent diagnosis and that the incidence and mortality differ both regionally and racially. While the molecular profiles for ccRCC are studied regionally through biopsy and sequencing techniques, the genomic landscape and ccRCC diversity data are not well-studied. We conducted a review of the known genomic data on 6 of the most clinically relevant DNA biomarkers in ccRCC: Von Hippel-Landau (vHL), Polybromo-1 (PBRM1), Breast Cancer Gene 1-Associated Protein 1 (BAP1), Histone-Lysine N-Methyltransferase Domain-Containing 2 (SETD2), Mammalian Target of Rapamycin (mTOR), and Lysine-Specific Demethylase 5C (KDM5C). …

Oaks Have A Lot Of Gall: The Intimate Interactions Of Oaks And Gall Wasps, Warren G. Abrahamson Ii

Faculty Journal Articles

This is a story about the interactions of oaks and herbivorous gall-inducing wasps. To set the stage, let’s first explore the diversity of oaks and oak gall wasps.

Stress Biology: Complexity And Multifariousness In Health And Disease, Emily M. Sontag

Biological Sciences Faculty Research and Publications

Preserving and regulating cellular homeostasis in the light of changing environmental conditions or developmental processes is of pivotal importance for single cellular and multicellular organisms alike. To counteract an imbalance in cellular homeostasis transcriptional programs evolved, called the heat shock response, unfolded protein response, and integrated stress response, that act cell-autonomously in most cells but in multicellular organisms are subjected to cell-nonautonomous regulation. These transcriptional programs downregulate the expression of most genes but increase the expression of heat shock genes, including genes encoding molecular chaperones and proteases, proteins involved in the repair of stress-induced damage to macromolecules and cellular structures. …

Synthesis And Evaluation Of 1,3-Disubstituted Imidazolidine-2,4,5-Triones As Inhibitors Of Pyruvate Carboxylase, Nicholas O. Schneider, Keandra Gilreath, Niel M. Henriksen, William A. Donaldson, Subhabrata Chaudhury, Martin St. Maurice

Biological Sciences Faculty Research and Publications

Substituted imidazolidinetriones (IZTs) have been identified as potent inhibitors of pyruvate carboxylase (PC) through an in silico screening approach. Alkyl 2-(2,4,5-trioxo-3-substituted imidazolidin-1-yl)acetates (6i–6r) are the most potent of the series, with IC50 values between 3 and 12 μM, and several IZTs demonstrate high passive permeability across an artificial membrane. IZTs are mixed-type inhibitors with respect to pyruvate and noncompetitive with respect to ATP. This class of inhibitors appears to be selective for PC. Inhibitors in the IZT series do not inhibit the metalloenzymes human carbonic anhydrase II and matrix metalloprotease-12, and they do not inhibit the related biotin-dependent enzyme, guanidine …

Ai Is A Viable Alternative To High Throughput Screening: A 318-Target Study, Martin St. Maurice

Biological Sciences Faculty Research and Publications

High throughput screening (HTS) is routinely used to identify bioactive small molecules. This requires physical compounds, which limits coverage of accessible chemical space. Computational approaches combined with vast on-demand chemical libraries can access far greater chemical space, provided that the predictive accuracy is sufficient to identify useful molecules. Through the largest and most diverse virtual HTS campaign reported to date, comprising 318 individual projects, we demonstrate that our AtomNet® convolutional neural network successfully finds novel hits across every major therapeutic area and protein class. We address historical limitations of computational screening by demonstrating success for target proteins without known binders, …

Importance Of Conserved Hydrophobic Pocket Region In Yeast Mitoribosomal Ml44 Protein For Mitotranslation And Transcript Preference, Jodie M. Box, Margo E. Higgins, Rosemary A. Stuart

Biological Sciences Faculty Research and Publications

The mitochondrial ribosome (mitoribosome) is responsible for the synthesis of key oxidative phosphorylation subunits encoded by the mitochondrial genome. Defects in mitoribosomal function therefore can have serious consequences for the bioenergetic capacity of the cell. Mutation of the conserved mitoribosomal mL44 protein has been directly linked to childhood cardiomyopathy and progressive neurophysiology issues. To further explore the functional significance of the mL44 protein in supporting mitochondrial protein synthesis, we have performed a mutagenesis study of the yeast mL44 homolog, the MrpL3/mL44 protein. We specifically investigated the conserved hydrophobic pocket region of the MrpL3/mL44 protein, where the known disease-related residue …

Clearing The Junq: The Molecular Machinery For Sequestration, Localization, And Degradation Of The Junq Compartment, Sarah Rolli, Chloe A. Langridge, Emily M. Sontag

Biological Sciences Faculty Research and Publications

Cellular protein homeostasis (proteostasis) plays an essential role in regulating the folding, sequestration, and turnover of misfolded proteins via a network of chaperones and clearance factors. Previous work has shown that misfolded proteins are spatially sequestered into membrane-less compartments in the cell as part of the proteostasis process. Soluble misfolded proteins in the cytoplasm are trafficked into the juxtanuclear quality control compartment (JUNQ), and nuclear proteins are sequestered into the intranuclear quality control compartment (INQ). However, the mechanisms that control the formation, localization, and degradation of these compartments are unknown. Previously, we showed that the JUNQ migrates to the nuclear …

Developmental Patterns Underlying Variation In Form And Function Exhibited By House Gecko Toe Pads, Aaron H. Griffing, Tony Gamble, Ashmika Behere, Timothy E. Higham, Greta M. Keller, John Resener, Thomas J. Sanger

Biological Sciences Faculty Research and Publications

Adhesive toe pads have evolved numerous times over lizard evolutionary history, most notably in geckos. Despite significant variation in adult toe pad morphology across independent origins of toe pads, early developmental patterns of toe pad morphogenesis are similar among distantly related species. In these distant phylogenetic comparisons, toe pad variation is achieved during the later stages of development. We aimed to understand how toe pad variation is generated among species sharing a single evolutionary origin of toe pads (house geckos—Hemidactylus). We investigated toe pad functional variation and developmental patterns in three species of Hemidactylus, ranging from highly …

Bacillus Subtilis-Derived Peptides Disrupt Quorum Sensing And Biofilm Assembly In Multidrug-Resistant Staphylococcus Aureus, Kyle R. Leistikow, Daniel S. May, Won Se Suh, Gabriel Vargas Asensio, Adam J. Schaenzer, Cameron R. Currie, Krassimira R. Hristova

Biological Sciences Faculty Research and Publications

Multidrug-resistant Staphylococcus aureus is one of the most clinically important pathogens in the world, with infections leading to high rates of morbidity and mortality in both humans and animals. The ability of S. aureus to form biofilms protects cells from antibiotics and promotes the transfer of antibiotic resistance genes; therefore, new strategies aimed at inhibiting biofilm growth are urgently needed. Probiotic species, including Bacillus subtilis, are gaining interest as potential therapies against S. aureus for their ability to reduce S. aureus colonization and virulence. Here, we search for strains and microbially derived compounds with strong antibiofilm activity against multidrug-resistant S. …

Parametric Study Of The Effect Of Increased Magnetic Field Exposure On Microalgae Chlorella Vulgaris Growth And Bioactive Compound Production, Sharanabasaweshwara Asundi, Sanurag Rout, Simone Stephen, Sanghamitra Khandual, Sandipan Dutta, Sandeep Kumar

Mechanical & Aerospace Engineering Faculty Publications

This parametric study aimed to analyze the effects of increased magnetic field exposure (MFE) on the growth and production of the bioactive compounds of Chlorella (C.) vulgaris. With the intent of studying the effect of an increased MFE, the magnetic field typically experienced by life on Earth was amplified by an order of magnitude. In the increased-MFE environment, six treatments of C. vulgaris with two repetitions for each treatment were exposed to a magnetic field of 5 Gauss (500 µT) about each axis, which was generated in a state-of-the-art Helmholtz cage. The treatments and the control were characterized by the …

Invasion Of Superbugs: Cockroach-Driven Outbreak Of Multidrug-Resistant Enterobacter In An Icu, Jennifer Hanrahan, Nicholas Schouten, Steven H. Fyffe, Annette Jencson, Stephanie Stroever

Department of Medicine Faculty Publications

Objective: To describe factors in an outbreak of multidrug-resistant Enterobacter cloacae (MRE) in an intensive care unit (ICU) over a 20-month period including the likely contribution of cockroaches to the outbreak.

Design: This is a retrospective descriptive study.

Setting: ICU in an urban hospital.

Patients: All patients admitted to the ICU during the 20-month outbreak period were included in the study.

Interventions: Infection prevention interventions included contact isolation, hand hygiene, dedicated patient equipment, environmental cultures, and pest control.

Results: 25 patients were identified as being colonized or infected with MRE. Relatedness of the outbreak strain and strains found in cockroaches …

Antiangiogenic Therapy Combined With Immune Checkpoint Blockade In Urothelial Cancer: Systematic Review And Meta-Analysis, Mohammad Jad Moussa, Iuliia Kovalenko, Emanuele Crupi, Ekaterina Proskuriakova, Yimin Geng, Giuseppe Fallara, Raed Benkhadra, Daniele Raggi, Matthew T. Campbell, Pavlos Msaouel, Omar Alhalabi

Department of Medicine Faculty Publications

Background: Antiangiogenic therapy had been tested in urothelial cancer (UC) without reaching the clinic.

Objective: We provide a systematic review and meta-analysis of trials to assess efficacy of immune checkpoint inhibitors (ICI) combined with antiangiogenic agents in UC.

Methods: Following PRISMA guidelines, we searched for trials with at least one arm of patients with UC treated with ICI plus antiangiogenics. Data were analyzed with the "meta" package from R using a one-staged frequentist meta-analysis.

Results: After screening 13,708 titles and abstracts, 9 studies were selected for analysis with 14 identified cohorts comprising 621 patients: 448 were ICI-naïve (ICI-N) and 173 …

Technological Advancements In Brunei’S Local Agriculture And Fisheries Companies: An Exploratory Study Based On Field Observations, Muhammad Firdaus Mujibuddin Syah Mustafa, Navaranjan Namasivayam, Hong Shyang Pei, Fatnin Farhanah Alihan, Amni Sahilah Sahrullamzah, Khairina Umairah Takiyaudin

ASEAN Journal on Science and Technology for Development

This exploratory study, through seven field observations and interviews, investigates the technological advancements transforming Brunei's agricultural landscape in pursuit of local production augmentation and self-sufficiency. It confronts challenges with emerging technologies like aquaponics, hydroponics, fertigation systems, closed-house poultry systems, and UV lighting, which hold promise for enhanced farming practices. The research provides a comprehensive assessment of current practices, including livestock management advancements, underscoring their potential to boost productivity, optimize resource use, and promote sustainable agriculture. Furthermore, it discusses the broader implications for industry standards, job employability, and alignment with Brunei's Vision 2035. The findings contribute invaluable insights, advocating for strategic …

Exploring The Impact Of Vented Packaging Configurations On Airflow Patterns And Cooling Consistency For Muskmelons In A Cold Storage Environment, Nur Wafidah Roslan, Namasivayam Navaranjan, Zohrah Sulaiman, Naseem Uddin

ASEAN Journal on Science and Technology for Development

The cooling effect of different vented packaging designs was investigated for packed muskmelons fruits in a commercial cold storage condition. Computational fluid dynamics (CFD) simulation and experiments were used. The airflow pattern, heat transfer and temperature profiles were predicted from simulation and analysed. The CFD results reveal an uneven and low efficient airflow distribution inside a commercially used vented packaging (Box A). This resulted slow cooling of the fruits in Box A. Two newly designed packaging (Box B and Box C) showed better airflow distribution around the fruits and cooled them faster than Box A. The design of Box C …

Physicochemical Characterization Of Edible Insect Oils: Insights Into Fatty Acid Composition, Thermal Behavior And Quality Parameters, Eng-Tong Phuah, Yee-Ying Lee, Teck-Kim Tang, Guanghui Li, Shyang-Pei Hong, Syazana Abdullah Lim

ASEAN Journal on Science and Technology for Development

Edible insects are emerging as a sustainable food source due to their high nutritional value. This study employed the three-phase partitioning (TPP) method to extract oils from sago worm (Rhynchophorus ferrugineus), superworm (Zophobas morio), and cricket (Acheta domesticus). The study evaluated and compared the physicochemical properties of these insect oils, including iodine value (IV), peroxide value (PV), p-anisidine value (p-AV), acid value (AV), refractive index (RI), thermal behavior, and fatty acid compositions. Results revealed that the sago worm exhibited the highest oil yield (47.8 ± 2.2%) compared to the superworm (23.8 ± 1.4%) and cricket (6.4 ± 0.6%). Cricket oil …

Recent Advance In Biodegradable Packaging From Banana Plant Feedstock: A Comprehensive Review, M. Atiq Juani, Namasivayam Navaranjan

ASEAN Journal on Science and Technology for Development

This review focuses on recent advances in biodegradable packaging derived from banana plant waste, highlighting its pivotal role in addressing environmental concerns linked to conventional packaging materials. The shift toward sustainable packaging stems from the urgent need to combat plastic pollution, reduce reliance on non-renewable resources, and foster sustainability in the food industry. Banana plants, known for generating significant organic waste during cultivation and processing, provide a valuable source for developing biodegradable packaging. Researchers have successfully transformed banana waste into innovative, recyclable, and eco-friendly packaging solutions, promoting a circular economy. Biodegradable packaging, in contrast to traditional materials derived from fossil …

Evaluation Of Physicochemical Properties Of Chicken Sausages Containing Whey Protein Isolate And Guar Gum, Nur Hamizah Hamid, Namasivayam Navaranjan

ASEAN Journal on Science and Technology for Development

The present work aims to evaluate the physicochemical properties and proximate composition of adding whey protein isolate (WPI) and guar gum (GG) as emulsion gels in chicken sausages formulated with different fat percentages. The fat reduction resulted in products having lower moisture content (p

The Effect Of Biochar From Plant Materials On Agricultural Acid Sulfate Soil: A Laboratory Incubation, Syazwan Sulaiman, Namasivayam Navaranjan, Guillermo Hernandez-Ramirez, Zohrah Sulaiman, Kathereen Liew

ASEAN Journal on Science and Technology for Development

The scarcity of suitable arable land has led to the development of acid sulfate soil for cultivation. The major problems of acid sulfate soil are the inherent low pH and available phosphorus (P) as well as the mobilization of toxic elements such as aluminium (Al) and iron (Fe), rendering the soil unfavourable for crop production. The present work aimed to evaluate the effect of biochar from plant materials on the selected parameters of acid sulfate soil in a laboratory incubation, with unamended control and dolomite treatment soils for comparison. The application of biochar significantly increased (P < 0.05) soil pH by 0.4-0.6 units as well as the soil available P by 13.1 mg kg-1 relative to the control. The soil exchangeable Al was significantly reduced (by 2.4 cmol kg-1 when compared with the control treatment. The dolomite treatment was superior relative to biochar application in increasing soil pH and decreasing Al. The dolomite application, however, was inferior to biochar treatment in increasing soil available P. Moreover, no favourable change was observed in available Fe with the applications of either biochar or lime. These results indicated that biochar has the potential for the amelioration of acid sulfate soil, especially in increasing available P. Further studies should explore the effectiveness of biochar and lime co-application in altering a wider range of soil chemical parameters to inform management options of acid sulfate soil for cultivation.

Unlocking Antioxidant Potential: Comparative Analysis Of Sembada 188 And Keladi Rice As Functional Ingredients In Novel Food Production, Mas Munira Rambli, Natasha Azamain, Eng-Tong Phuah

ASEAN Journal on Science and Technology for Development

Rice (Oryza sativa L.) is an essential crop that is a dietary staple for more than half of the world's population. There is currently a movement in consumer behaviour toward healthier food consumption, which is fuelling interest in functional diets like coloured rice. Sembada 188 and Keladi rice are underutilised in Brunei Darussalam and are expected to have functional qualities. A comparison of antioxidant properties between Sembada 188 and Keladi rice was performed in this study. This research produced puffed rice treats prepared by steaming rice, washing, drying for 6-8 hours at 60℃, deep frying for 25 seconds at 180℃, …

Preliminary Study On The Effects Of Vinegar As Pre- Treatment For The Oven-Drying Of Pacific Yellowtail Emperor (Lethrinus Atkinsoni) Fillets, Nurisa A. Suhaili, Rafael S. Jamih, Normina A. Abubakar, Jaro O. Ajik, Merilyn Q. Amlani

ASEAN Journal on Science and Technology for Development

This study aimed to assess the impact of various vinegar compositions used as pre-treatment for Pacific Yellowtail Emperor (PYE) fillets during the oven-drying process, with a focus on moisture content and optimal drying conditions. Two types of commercially available vinegar, Superior Vinegar and Datu Puti Vinegar, were compared, and different drying temperatures were evaluated. The investigation revealed that the drying temperature significantly influenced the moisture content of the dried PYE fillets. Among the tested temperatures (40°C, 60°C, and 80°C), the most favorable outcome in terms of moisture content was achieved when fillets were dried at 80°C for a duration of …

Application Of Three Of Selected Medicinal Plant Extracts In Brunei Darussalam To Improve Shelf Life Of Poultry Product, Hazirah Abd Hamid, Namasivayam Navaranjan, Zohrah Sulaiman, Aida Maryam Binti Hj Basri

ASEAN Journal on Science and Technology for Development

Abstract. Bioactive compounds from plant derived in food application become increasingly in demand due to natural and nutritionally safe products. Due to some issues concerning food safety on the excessive use of synthetic preservatives; the present study aims to investigate the natural alternatives to synthetic antimicrobial food additives. The chicken meat’s shelf life was studied by adopting bio-based antimicrobial agents using three of selected native medicinal plants; P. betle, A. catechu, and A. tricolor, against common foodborne pathogens; E. coli, P. aeruginosa, S. aureus, and Salmonella spp. The overall results revealed that, all study extracts possessed antioxidant properties by DPPH …

Prevalence Of Resistant Escherichia Coli Isolated From Local Meats Sold In Tema Metropolis, Ghana, Frederick Adzitey, Innocent Allan Anachinaba, Charles Addo-Quaye Brown, Nurul Huda, Masmuniri Rambli

ASEAN Journal on Science and Technology for Development

Contamination of meat by Escherichia coli (E. coli) can take its source from the live animal or by cross contamination. The study determined the prevalence of resistance of E. coli isolated from locally produced meats in the Tema Metropolis. Beef (n=200), chicken (n=200) and pork (n=200) were randomly selected and evaluated for the presence of E. coli using the procedure in the Bacteriological Analytical Manual of USA-FDA. The disc diffusion method was used for antibiotic susceptibility test of E. coli (n=55) isolates. Locally produced beef (67%), chicken (41%) and pork (23%) were contaminated by E. coli. Escherichia coli isolates were …

Byproducts Of Tropical Marine Processing As A Candidate For Industrial Food Ingredients: An Appraisal On Macro And Micronutrients, Abdul Aziz Jaziri, Hajariah Hasanuddin, Rossita Shapawi, Ruzaidi Azli Mohd Mokhtar, Wan Norhana Md. Noordin, Masmunira Rambli, Nurul Huda

ASEAN Journal on Science and Technology for Development

Tropical marine fish is a main raw material for surimi processing plants, including golden threadfin bream (Nemipterus virgatus Houttuyn, 1782) and swallowtail dwarf monocle bream (Parascolopsis eriomma Jordan & Richardson, 1909). After processing, more than 60% of fish are considered as byproducts (i.e., head, viscera, skin, bones, fins and scale), and tend to discard due to poor-utilization. Hence, this paper aims to evaluate macro- and micro-nutrients derived from golden threadfin bream (GTB) and swallowtail dwarf monocle bream (SDMB). The higher content of protein (25.31 ± 0.81%) was observed in the skin part of GTB, followed by the flesh (21.26 ± …

Antioxidant And Antimicrobial Properties Of Yellow Mealworm (Tenebrio Molitor) Protein Concentrates And Hydrolysates Derived From Varied Dietary Regimens, Shyang-Pei Hong, Eng-Tong Phuah, Wey-Lim Wong, Yee-Ying Lee, Teck-Kim Tang, Ali Yassoralipour

ASEAN Journal on Science and Technology for Development

The larval stage of the darkling beetle, Tenebrio molitor, often referred to as the yellow mealworm, has received significant attention as a promising source of high-quality protein for human consumption due to its exceptional nutritional profile. This study focused on assessing the antioxidant and antimicrobial activities of protein concentrates and hydrolysates obtained from mealworm specimens raised under distinct dietary conditions. One cohort of mealworms was sustained on food waste comprising rice bran, milled corn, and carrots (self-bred) (SM), while another group was exclusively provided with rice bran (commercially fed) (CM). Enzymatic hydrolysis of mealworm protein was accomplished using protease enzymes …

Release Behavior Of Butterfly Pea Anthocyanins From Sago Starch Micro-Composite Films Under Food Stimulants, Afiqah Nabihah Ahmad, Eng Tong Phuah, Namasivayam Navaranjan, Syazana Abdullah Lim

ASEAN Journal on Science and Technology for Development

This study investigates the release behaviour of Butterfly Pea (BP) anthocyanins from Sago starch micro-composite (SMC) films in the presence of food stimulants. To comprehensively describe the release profiles of BP from SMC, six well-established kinetic release models were employed which includes Korsmeyer-Peppas, zero-order, first-order, second-order, Higuchi, and Hixson-Crowell models. These models played a crucial role in examining how the release fraction changes over time, facilitating a comprehensive understanding of the release kinetics of BP anthocyanins. Our data analysis revealed a strong conformity with the Korsmeyer-Peppas model, suggesting its applicability in describing the release of BP anthocyanins from SMC. The …