Life Sciences Commons^™

Different Substrate Selectivity And Product Patterns Of Immobilized Thermophilic Lipases From Geobacillus Stearothermophilus, Anoxybacillus Flavithermus, And Thermomyces Lanuginosus For Glyceryl Decanoate Synthesis, Teif A. Najm, Marie K. Walsh, Namhyeon Park

Nutrition, Dietetics, and Food Sciences Faculty Publications

Lipases can catalyze synthesis reactions in a micro aqueous system, producing useful partial glycerides (mono- and diglycerides), and these compounds are commonly utilized in different products as surfactants. Depending on the microbial sources for lipases, immobilization conditions, and starting substrates for synthesis reaction, the composition and yields of the resulting partial glycerides could be variable. These differences could lead to the final efficacy of partial glycerides as surfactants in targeted products. Therefore, it is necessary to establish a group of immobilized lipases from different microbial sources with information about substrate specificity to produce effective partial glycerides for various product types. …

Contextualizing The Revised Patient Perception Of Patient-Centeredness (Pppc-R) Scale In Primary Healthcare Settings: A Validity And Reliability Evaluation Study, Lingrui Liu, Rubee Dev, Yiran Li, Tianyu Huang, Ruilin Wang, Li Kuang, Ruonan Huang, Xinfang Li, Edmundo Roberto Melipillán, Shuaixiang Zhao, Wenjun He, Xiaohui Wang, Nan Zhang, Dong Roman Xu

Faculty, Staff and Student Publications

BACKGROUND: An English version of the Patient Perception of Patient-Centeredness (PPPC) scale was recently revised, and it is necessary to test this instrument in different primary care populations.

AIM: This study aimed to assess the validity and reliability of a Chinese version of the PPPC scale.

DESIGN: A mixed method was used in this study. The Delphi method was used to collect qualitative and quantitative data to address the content validity of the PPPC scale by calculating the Content Validity Index, Content Validity Ratio, the adjusted Kappa, and the Item Impact Score. Confirmatory factor analysis (CFA) and exploratory factor analysis …

Stemdriver: A Knowledgebase Of Gene Functions For Hematopoietic Stem Cell Fate Determination, Kexin Huang, Yang Liu, Grant Wang, Ruihan Luo, Ting Niu, Yuzhou Feng, Haixia Xu, Pora Kim, Xiaobo Zhou

Faculty, Staff and Student Publications

StemDriver is a comprehensive knowledgebase dedicated to the functional annotation of genes participating in the determination of hematopoietic stem cell fate, available at http://biomedbdc.wchscu.cn/StemDriver/. By utilizing single-cell RNA sequencing data, StemDriver has successfully assembled a comprehensive lineage map of hematopoiesis, capturing the entire continuum from the initial formation of hematopoietic stem cells to the fully developed mature cells. Extensive exploration and characterization were conducted on gene expression features corresponding to each lineage commitment. At the current version, StemDriver integrates data from 42 studies, encompassing a diverse range of 14 tissue types spanning from the embryonic phase to adulthood. In order …

Fusionpdb:: A Knowledgebase Of Human Fusion Proteins

Faculty, Staff and Student Publications

Tumorigenic functions due to the formation of fusion genes have been targeted for cancer therapeutics (i.e. kinase inhibitors). However, many fusion proteins involved in various cellular processes have not been studied for targeted therapeutics. This is because the lack of complete fusion protein sequences and their whole 3D structures has made it challenging to develop new therapeutic strategies. To fill these critical gaps, we developed a computational pipeline and a resource of human fusion proteins named FusionPDB, available at https://compbio.uth.edu/FusionPDB. FusionPDB is organized into four levels: 43K fusion protein sequences (14.7K in-frame fusion genes, Level 1), over 2300 + 1267 …

Ageannomo: A Knowledgebase Of Multi-Omics Annotation For Animal Aging, Haixia Xu, Qingxuan Li, Yuhao Jia, Liyu Huang, Pora Kim, Xiaobo Zhou

Faculty, Staff and Student Publications

Aging entails gradual functional decline influenced by interconnected factors. Multiple hallmarks proposed as common and conserved underlying denominators of aging on the molecular, cellular and systemic levels across multiple species. Thus, understanding the function of aging hallmarks and their relationships across species can facilitate the translation of anti-aging drug development from model organisms to humans. Here, we built AgeAnnoMO (https://relab.xidian.edu.cn/AgeAnnoMO/#/), a knowledgebase of multi-omics annotation for animal aging. AgeAnnoMO encompasses an extensive collection of 136 datasets from eight modalities, encompassing 8596 samples from 50 representative species, making it a comprehensive resource for aging and longevity research. AgeAnnoMO characterizes …

Fusionneoantigen: : A Resource Of Fusion Gene-Specific Neoantigens, Xiaobo Zhou, Pora Kim

Faculty, Staff and Student Publications

Among the diverse sources of neoantigens (i.e. single-nucleotide variants (SNVs), insertions or deletions (Indels) and fusion genes), fusion gene-derived neoantigens are generally more immunogenic, have multiple targets per mutation and are more widely distributed across various cancer types. Therefore, fusion gene-derived neoantigens are a potential source of highly immunogenic neoantigens and hold great promise for cancer immunotherapy. However, the lack of fusion protein sequence resources and knowledge prevents this application. We introduce 'FusionNeoAntigen', a dedicated resource for fusion-specific neoantigens, accessible at https://compbio.uth.edu/FusionNeoAntigen. In this resource, we provide fusion gene breakpoint crossing neoantigens focused on ∼43K fusion proteins of ∼16K in-frame …

Cov2var, A Function Annotation Database Of Sars-Cov-2 Genetic Variation, Jianguo Wen, Weiling Zhao, Pora Kim, Xiaobo Zhou

Faculty, Staff and Student Publications

The COVID-19 pandemic, caused by the coronavirus SARS-CoV-2, has resulted in the loss of millions of lives and severe global economic consequences. Every time SARS-CoV-2 replicates, the viruses acquire new mutations in their genomes. Mutations in SARS-CoV-2 genomes led to increased transmissibility, severe disease outcomes, evasion of the immune response, changes in clinical manifestations and reducing the efficacy of vaccines or treatments. To date, the multiple resources provide lists of detected mutations without key functional annotations. There is a lack of research examining the relationship between mutations and various factors such as disease severity, pathogenicity, patient age, patient gender, cross-species …

Drmref: Comprehensive Reference Map Of Drug Resistance Mechanisms In Human Cancer, Kexin Huang, Jiajia Liu, Grant Wang, Pora Kim, Qianqian Song, Xiaobo Zhou

Faculty, Staff and Student Publications

Drug resistance poses a significant challenge in cancer treatment. Despite the initial effectiveness of therapies such as chemotherapy, targeted therapy and immunotherapy, many patients eventually develop resistance. To gain deep insights into the underlying mechanisms, single-cell profiling has been performed to interrogate drug resistance at cell level. Herein, we have built the DRMref database (https://ccsm.uth.edu/DRMref/) to provide comprehensive characterization of drug resistance using single-cell data from drug treatment settings. The current version of DRMref includes 42 single-cell datasets from 30 studies, covering 382 samples, 13 major cancer types, 26 cancer subtypes, 35 treatment regimens and 42 drugs. All datasets in …

Irrigation Of Sand-Based Creeping Bentgrass Putting Greens With Nanobubble-Oxygenated Water, Eric J. Deboer, Michael J. Richardson, John Mccalla

Horticulture Faculty Publications and Presentations

ultural and environmental factors can place creeping bentgrass (Agrostis stolonifera) under extreme stress during the summer months. This stress, coupled with the growth adaptation of creeping bentgrass, can result in shallow, poorly rooted stands of turf. To enhance root zone oxygen and rooting of creeping bentgrass, golf courses use methods such as core and solid-tine aerification, and sand topdressing. An additional method of delivering oxygen to the soil could be irrigation with nanobubble-oxygenated water. The properties of nanobubbles (NBs) allow for high gas dissolution rates in water. Irrigating with NB-oxygenated water sources may promote increased rooting of creeping …

Sirtuin 2 Inhibition Modulates Chromatin Landscapes Genome-Wide To Induce Senescence In Atrx-Deficient Malignant Glioma, Prit Benny Malgulwar, Carla Danussi, Sharvari Dharmaiah, William Johnson, Anand Singh, Arvind Rao

Faculty, Staff and Student Publications

BACKGROUND: Functional inactivation of ATRX characterizes large subgroups of malignant gliomas in adults and children. ATRX deficiency in glioma induces widespread chromatin remodeling, driving transcriptional shifts and oncogenic phenotypes. Effective strategies to therapeutically target these broad epigenomic sequelae remain undeveloped.

METHODS: We utilized integrated multiomics and the Broad Institute Connectivity Map (CMAP) to identify drug candidates that could potentially revert ATRX-deficient transcriptional changes. We then employed disease-relevant experimental models to evaluate functional phenotypes, coupling these studies with epigenomic profiling to elucidate molecular mechanism(s).

RESULTS: CMAP analysis and transcriptional/epigenomic profiling implicated the Class III HDAC Sirtuin2 (SIRT2) as a central mediator …

Current And Future Therapeutic Strategies For High-Grade Gliomas Leveraging The Interplay Between Epigenetic Regulators And Kinase Signaling Networks, Lea M Stitzlein, Jack T Adams, Erin N Stitzlein, Richard W Dudley, Joya Chandra

Faculty, Staff and Student Publications

Targeted therapies, including small molecule inhibitors directed against aberrant kinase signaling and chromatin regulators, are emerging treatment options for high-grade gliomas (HGG). However, when translating these inhibitors into the clinic, their efficacy is generally limited to partial and transient responses. Recent studies in models of high-grade gliomas reveal a convergence of epigenetic regulators and kinase signaling networks that often cooperate to promote malignant properties and drug resistance. This review examines the interplay between five well-characterized groups of chromatin regulators, including the histone deacetylase (HDAC) family, bromodomain and extraterminal (BET)-containing proteins, protein arginine methyltransferase (PRMT) family, Enhancer of zeste homolog 2 …

Dimerization Of The 4ig Isoform Of B7-H3 In Tumor Cells Mediates Enhanced Proliferation And Tumorigenic Signaling, Margie N Sutton, Sarah E Glazer, Riccardo Muzzioli, Ping Yang, Seth T Gammon

Faculty, Staff and Student Publications

B7-H3 (CD276) has two isoforms (2Ig and 4Ig), no confirmed cognate receptor, and physiological functions that remain elusive. While differentially expressed on many solid tumors correlating with poor survival, mechanisms of how B7-H3 signals in cis (tumor cell) versus in trans (immune cell co-regulator) to elicit pro-tumorigenic phenotypes remain poorly defined. Herein, we characterized a tumorigenic and signaling role for tumor cell-expressed 4Ig-B7-H3, the dominant human isoform, in gynecological cancers that could be abrogated upon CRISPR/Cas9 knockout of B7-H3; tumorigenesis was rescued upon re-expression of 4Ig-B7-H3. Size exclusion chromatography revealed dimerization states for the extracellular domains of both human 4Ig- …

Pancanqtlv20: A Comprehensive Resource For Expression Quantitative Trait Loci Across Human Cancers, Chengxuan Chen, Yuan Liu, Mei Luo, Jingwen Yang, Yamei Chen, Joseph Zhou, Lixia Diao, Leng Han

Faculty, Staff and Student Publications

Expression quantitative trait locus (eQTL) analysis is a powerful tool used to investigate genetic variations in complex diseases, including cancer. We previously developed a comprehensive database, PancanQTL, to characterize cancer eQTLs using The Cancer Genome Atlas (TCGA) dataset, and linked eQTLs with patient survival and GWAS risk variants. Here, we present an updated version, PancanQTLv2.0 (https://hanlaboratory.com/PancanQTLv2/), with advancements in fine-mapping causal variants for eQTLs, updating eQTLs overlapping with GWAS linkage disequilibrium regions and identifying eQTLs associated with drug response and immune infiltration. Through fine-mapping analysis, we identified 58 747 fine-mapped eQTLs credible sets, providing mechanic insights of gene regulation in …

Fak Drives Resistance To Therapy In Hpv-Negative Head And Neck Cancer In A P53-Dependent Manner, Phillip M Pifer, Liangpeng Yang, Manish Kumar, Tongxin Xie, Mitchell Frederick, Beth Beadle, Jessica Molkentine, Annika Dhawan, Mohamed Abdelhakiem, Abdullah A Osman, Brian J Leibowitz, Jeffrey N Myers, Curtis R Pickering, Vlad C Sandulache, John Heymach, Heath D Skinner

Faculty, Staff and Student Publications

PURPOSE: Radiation and platinum-based chemotherapy form the backbone of therapy in human papillomavirus (HPV)-negative head and neck squamous cell carcinoma (HNSCC). We have correlated focal adhesion kinase (FAK/PTK2) expression with radioresistance and worse outcomes in these patients. However, the importance of FAK in driving radioresistance and its effects on chemoresistance in these patients remains unclear.

EXPERIMENTAL DESIGN: We performed an in vivo shRNA screen using targetable libraries to identify novel therapeutic sensitizers for radiation and chemotherapy.

RESULTS: We identified FAK as an excellent target for both radio- and chemosensitization. Because TP53 is mutated in over 80% of HPV-negative HNSCC, we …

Development Of A Rabbit Human Glioblastoma Model For Testing Of Endovascular Selective Intra-Arterial Infusion (Esia) Of Novel Stem Cell-Based Therapeutics, Peter Kan, Visish M Srinivasan, Joy Gumin, Roberto Garcia, Stephen R Chen, Dalis E Collins, Daniel Ledbetter, Jason Huse, Zean Aaron Evan Luna, Ariadna Robledo, Viren Vasandani, Abhijit Rao, Sanjay K Singh, Elizabeth J Shpall, Juan Fueyo, Candelaria Gomez-Manzano, Frederick F Lang

Faculty, Staff and Student Publications

BACKGROUND: Endovascular selective intra-arterial (ESIA) infusion of cellular oncotherapeutics is a rapidly evolving strategy for treating glioblastoma. Evaluation of ESIA infusion requires a unique animal model. Our goal was to create a rabbit human GBM model to test IA infusions of cellular therapies and to test its usefulness by employing clinical-grade microcatheters and infusion methods to deliver mesenchymal stem cells loaded with an oncolytic adenovirus, Delta-24-RGD (MSC-D24).

METHODS: Rabbits were immunosuppressed with mycophenolate mofetil, dexamethasone, and tacrolimus. They underwent stereotactic xenoimplantation of human GBM cell lines (U87, MDA-GSC-17, and MDA-GSC-8-11) into the right frontal lobe. Tumor formation was confirmed on …

The Effects Of Combined Aquatic Exercise On Physical Performance And Metabolic Indices In Overweight Healthy Older Adults, Shiva Ebrahimpour Nosrani, Bakhtyar Tartibian, Rasoul Eslami, Carlos Farinha, João Serrano, José Pedro Ferreira, Ana Maria Texeira

International Journal of Exercise Science

International Journal of Exercise Science 16(4): 1499-1513, 2023. Addressing overweight and obesity to promote healthy aging is essential. Exercise is an outstanding approach to manage metabolic and physical dysfunction. Aquatic exercise has been recommended for older individuals due to reduced weight pressure on joints. The aim of this study was to determine the effects of twenty-eight weeks of combined aquatic exercise (aerobic and resistance) in overweight healthy older individuals. Thirty-two subjects of both genders with mean age of 72.06 ± 5.8 years were randomly assigned into two groups: an aquatic exercise group (EG; n = 19) and a control group …

Body Mass Index Superior To Body Adiposity Index In Predicting Adiposity In Female Collegiate Athletes., Annika Grams, Anthony Acevedo, Riley Morton, Payton Price, Kyli Alvarez, Malia Nowlen, Estephania Campa, Zachary Zeigler

International Journal of Exercise Science

International Journal of Exercise Science 16(4): 1487-1498, 2023. Body mass index (BMI) is moderately correlated with %Fat and often used to assess obesity in athletes. Limited research assesses BMI as a surrogate for %Fat in female collegiate athletes. Body Adiposity Index (BAI) is an anthropometric measurement suggested to be superior to BMI at predicting adiposity but has not been well assessed within female athletic populations. This study aimed to determine if BAI is superior to other anthropometric indices to predict %Fat in female collegiate athletes and college-aged female non-athletes. Collegiate female athletes and female non-athletes were invited into the laboratory …

Low Energy Availability, Disordered Eating, Exercise Dependence And Fueling Strategies In Trail Runners, Keely Henniger, Kelly Pritchett, Namrita Kumar Brooke, Leah Dambacher

International Journal of Exercise Science

International Journal of Exercise Science 16(2): 1471-1486, 2023. Under fueling, disordered eating (DE), exercise dependence (EXD), and high training demands relative to energy intake may increase the risk of low energy availability (LEA) in endurance and ultra-endurance athletes. The purpose of this study was to evaluate the prevalence of LEA risk and relationship with risk of DE, EXD, and fueling habits during training and competition in endurance runners. Trail runners between the age of 18-40 (n = 1,899; males: n = 510, females: n = 1,445) completed a 45-question survey using Qualtrics that included training and racing characteristics, questions …

The Effects Of Wearing A Portable Media Armband On Muscle Activation Of The Biceps Brachii, W. Steven Tucker, Melissa J. Allen, Ashley E. Patterson, Alex W. Fotioo

International Journal of Exercise Science

International Journal of Exercise Science 16(1): 1461-1470, 2023. Portable media armbands are commonly used among the physically active population. Their effect on muscle function has not been established. The purpose of this study was to determine if muscle activation of the biceps brachii is influenced by wearing a portable media armband during an elbow flexion exercise. Eighteen participants (11 males: age = 22.5 ± 2.1 years, height = 178.3 ± 5.2 cm, mass = 85.0 ± 6.5 kg; 7 females: age = 22.9 ± 2.5 years, height = 168.3 ± 5.7 cm, mass = 72.3 ± 12.2 kg) with no …

Dynamics Of Meiobenthic Fauna In A Tropical Sandy Coast (Chennai, Bay Of Bengal) With Reference To The Physicochemical Parameters, Madhavan Kesavaraj, Md Anwar Nawaz, Zahara Tasneem, Mohammed Asjad Shams Tabrez, Kareem Altaff, Mohamed Saquib Naveed

Turkish Journal of Zoology

The term “meiobenthos” refers to a diverse community of organisms inhabiting the interstitial spaces between sand grains retained on sieve sizes ranging between 38 to 500 μm. This study investigates the diversity and density of meiobenthic communities across five locations along the Chennai coast. We examined the dominant meiobenthic groups, with nematodes exhibiting high dominance at Napier station (288.6 ± 91.07 ind.10cm²) and harpacticoids dominating at Marina station (449.88 ± 264.3 ind.10cm²). To establish the relationship between meiobenthic organisms and environmental parameters, we analyzed seven physicochemical factors throughout the study period. The results indicate a negative correlation between ammonia, nitrate, …

Coral Cover Percentage And Health Condition In Tioman Island Marine Protected Area, Pahang, Malaysia, Nur Addawiah Mohamad Rodzi, Mohamed Fahmy Yusof, Zaidi Che Cob

Turkish Journal of Zoology

Continuous evaluation and monitoring of coral percentage cover and health status is critical for enhancing coral reef resilience management. The present study aimed to determine the coverage and coral status at important sites of Tioman Island Marine Park, which include Renggis Island, Tiong Point and Tekek. Surveillance video recording and in situ observation were carried out using the Coral Video Transect (CVT) method, which were analyzed using the Coral Point Count with Excel extension (CPCe) software. The overall health status for the study area was considered as “fair” with 41.61% ± 4.46% of mean live coral coverage. Among the stations …

An Update On The Phylogeny And Biogeographical History Of Rhipicephalus Sanguineus Complex, Olcay Heki̇moğlu

Turkish Journal of Zoology

Rhipicephalus sanguineus complex is among the most studied hard tick species due to its worldwide distribution and its ability to transmit several pathogens. In this study, new local data and recent global findings were used to reevaluate the evolutionary history and phylogeny of the R. sanguineus complex. Seventy-nine samples of Rhipicephalus sp., which were collected from 32 different localities of Türkiye and one locality from Northern Cyprus, were analyzed using two mitochondrial (mt 16S rDNA, mt 12S rDNA) and one nuclear (ITS2) markers. The findings from phylogenetic trees indicate the presence of a third genetically distinct lineage of R. sanguineus …

The Range Dynamics Of A Cactophilic Drosophila Species Under Climate Change Scenarios, Banu Şebnem Önder, Utku Perktaş

Turkish Journal of Zoology

In this study, we evaluated the historical demography of a cactophilic Drosophila species (Drosophila gouveai) based on previously published mitochondrial DNA (mtDNA) data ecological niche modelling. We particularly aimed to test the effect of climate change on the historical demography of D. gouveai during the late Quaternary and the future of the species. For this, we also modelled its host cacti species in its distribution range to reach a more robust biogeographic conclusion. Our results indicate that D. gouveai was as sensitive to climate change as its hosts were. This species experienced an almost complete range shift, range contraction after …

Diet And Reproductive Outputs Of Common Barn-Owl (Tyto Alba) During The Common Vole (Microtus Arvalis) Outbreak And Crash, Gyozo F. Horvath, Adrienn Horváth

Turkish Journal of Zoology

In this paper, we investigated the relationship between the breeding parameters and food composition of the common barnowl (Tyto alba) comparing the outbreak and subsequent crash periods of the common vole (Microtus arvalis) as the barn owl’s main prey. For the analyses, data of 29 (2014 outbreak: 6, 2016 crash: 8; 2019 outbreak: 7, 2021 crash: 7) breeding pairs of barn owls were selected. First, we examined the differences between the breeding parameters (clutch size, number of hatchlings and fledglings), the main and alternative prey taxa (common vole and Apodemus genus), the two derived indices (trophic level index, Microtinae/Murinae ratio) …

Vigilance Behavior Of Common Crane Grus Grus In Flocks During Spring, Summer, And Autumn, Kristina Kondrakova, Alexander Sharikov

Turkish Journal of Zoology

Vigilance is a key behavioral element aimed to detect potential predators or rivals. In this study, we examined the vigilance levels of common cranes that exhibit flocking behavior during the spring, summer, and autumn seasons. We considered the influence of both social (age, presence of offspring, and flock size) and environmental factors (habitat type, time of day, and study period). Parents allocated more time for vigilance than nonparents and juveniles. The alertness of nonparents was lower in flocks of size 51–150 individuals compared to flocks under 50 and over 150 birds. Juveniles increased their vigilance at the end of the …

Can Wildlife Mortality On A Local Road Tell Something General? An Answer From A Protected Area In South-Western Romania, Diana Cupşa, Severus Daniel Covaciu Marcov, Robert Liviu Mihai Rengle, Amalia Raluca Dumbrava, Sára Ferenti, Adriana Petruş Vancea

Turkish Journal of Zoology

Between June 2020 and May 2021, we studied the fauna road mortality on a recently asphalted local road in a protected area in southwestern Romania (Iron Gates Natural Park–IGNP). Despite our expectation of reduced road mortality because of the very low traffic (3.97 cars/hour), numerous animals belonging to a high number of taxa were killed. Animals were killed throughout the entire year, even amphibians in the winter months, which normally should hibernate in that period. Road mortality differences between periods and sectors were obvious. Plant assemblages near the road influence the composition and intensity of road mortality. Diverse habitats near …

On The Oviposition Of Homonota Aff. Darwinii In The Puna Region Of The Central Andes Of Argentina, Franco Valdez Ovallez, Rodrigo Gómez Alés, Rodrigo Nieva Cocilio, Tomás Martínez, Juan Carlos Acosta, José Villavicencio, Graciela Blanco

Turkish Journal of Zoology

Communal nest egg-laying refers to females laying their eggs with those of their conspecifics under or within artificial or natural structures. Homonota aff. darwinii is a recently discovered species that has not yet been formally described. The objective of this work is to characterise the oviposition of this species in the Puna region in the Central Andes of Argentina. We recorded the type and surface of the rocks where the eggs were laid, the temperature of the substrate, and the temperature of the rock surface facing the substrate. In addition, we recorded the daily temperature variation that a randomly selected …

The Association Between Clai Polymorphism And Hygienic Behavior In Apis Mellifera, İnci̇ Şahi̇n Negi̇ş, Mustafa Ki̇bar, İbrahi̇m Ayteki̇n

Turkish Journal of Zoology

Hygienic behavior represents one of the most prominent disease resistance mechanisms developed by honeybees. This behavior is known to be influenced by the genotype and environmental factors. Therefore, this study aimed to investigate the effect of SNP-8 polymorphism and environmental factors on hygienic behavior in different Apis mellifera breeds. A total of fourteen colonies and 148 bees from seven different bee breeds were used for the Pin-killed Brood Assay (PKB) test and PCR-RFLP analysis, respectively. The PKB assay revealed a wide range of hygienic behavior, spanning from 68% to 100% across the fourteen colonies. The frequencies of the H (High) …

Effectiveness Of Pharmacotherapies For Diabetes On Nicotine, Food, And Water Intake In Insulin-Resistant Rats, Laura O'Dell

Selected Works Temporary Series

No abstract provided.

Effectiveness Of Pharmacotherapies For Diabetes On Nicotine, Food, And Water Intake In Insulin-Resistant Rats, Laura O'Dell

Departmental Papers (Psych)

No abstract provided.