Life Sciences Commons^™

Performance Of Finishing Nellore Beef Steers In Intensively Managed Pastures And Silvopastoral Systems In Southeast Of Brazil, P. P. A. Oliveira, Neto R. Pasquini, G. S. Pádua, L. H. C. Junior, R. Vechi, A. J. Furtado, G. V. Silva, A. A. Lobo, A. L. Abdalla-Filho, A. F. Pedroso, P. H. M. Rodrigues

IGC Proceedings (1977-2023)

This study evaluated the average daily weight gain (ADG), stocking rates, and live weight gain per hectare (LWG) in different intensified animal production systems. The experiment was carried out from September 2020 to September 2021 at Embrapa Southeast Livestock, São Carlos, SP, Brazil. Thirty Nellore steers (285±21 kg of live weight and 12±13 months old) were randomly distributed into five treatments, with two replicates: 1) intensively managed and irrigated Megathyrsus maximus cv. Tanzânia pasture overseeded in the dry season with Avena byzantina and Lolium multiflorum (IHS); 2) intensively managed rainfed M. maximus cv. Tanzânia pasture (RHS); 3) intensively managed rainfed …

Agricultural Performance Of Diverse Pastures Of Complementary Species And Monoculture Pastures Defoliated According To The Leaf Regrowth Stage Window Of Opportunity Criterion, B. A. Oliviera, I. F. López, L. M. Cranston, D. J. Donaghy, P. D. Kemp, J. Dörner

IGC Proceedings (1977-2023)

In a diverse pasture of complementary species (DPCS), individual species fulfil agro-ecological functions that confer growth asynchrony and complementarity of ecosystem functions. These attributes provide yield consistency with a more even forage supply pattern across the year compared to monocultures. A common leaf regrowth stage window opportunity (LSWO) for the diverse species enables pasture defoliation that stimulates growth and persistence. The study assessed seasonal and annual growth traits of Lolium perenne (Lp), Bromus valdivianus (Bv) and Dactylis glomerata (Dg) as single grass species (Mono) sown with Trifolium repens (Tr) and as DPCS with the four species (Lp+Bv+Dg+Tr=Mix). The defoliation criteria …

Forage Intake Of Nellore Steers Grazing A Cajanus CajanLegume-Grass Intercropped Pasture, P. P. A. Oliviera, A. J. Furtado, J. F. Bruno, Neto R. Pasquini, G. V. Da Silva, A. A. Lobo, A. L. Abdalla-Filho, F. Perna Junior, T. C. Alves, S. R. Medeiros, A. F. Pedroso, P. H. M. Rodrigues

IGC Proceedings (1977-2023)

This study evaluated forage, supplement, and total (forage + supplement) dry matter intake (DMI, expressed as kg/day and as percentage of average live weight, %ALW) of Nellore steers in different production systems, including a Cajanus cajan (Pigeon pea) legume-grass intercropped pasture by using external (titanium dioxide, TiO2) and internal (indigestible neutral detergent fiber, iNDF) markers. The experiment was carried out at Embrapa Southeast Livestock, São Carlos, SP, Brazil, in the rainy (January) and dry (July) seasons of 2021. Eighteen animals Nellore steers were randomly distributed into three treatments with three replications (1.5 ha paddocks each): 1) degraded pasture of Urochloa …

Theobroma Cacao Pod Silage Diets; Effect On Mineral And Anti-Nutrients Utilization By Goats, O. B. Omotoso, Adebowale N. Fajemisin, J. A. Alokan

IGC Proceedings (1977-2023)

A 63-day study was conducted to evaluate the mineral and anti-nutrients utilization and weight gain by west African dwarf goats fed Theobroma cacao pod silage diets. Cocoa pod husk used was collected, crushed to 2 cm particle size, divided into 4 equal portions, and ensiled differently with synthetic and non-synthetic fertilizer for 28 days under anaerobic conditions to increase the nutrients. Thereafter the ensiled products were dried and incorporated with other convectional feed ingredients at fixed amount to make four diets to feed twenty-four goats (six goats per treatment). Nutrient, mineral and anti-nutrient composition were assayed; sex effect on intake …

Livestock Production And Economic Implications From Augmenting Degraded Rangeland With Atriplex Halimus And Salsola Vermiculata In Northwest Syria, A. E. Osman, F. Bahhadi, N. Hassan, F. Ghassali, T. Al Ibrahim

IGC Proceedings (1977-2023)

Three stocking rates (low: one sheep 2.25 ha-1, medium: one sheep 1.5 ha-1 year-1 and high: one sheep 0.75 ha-1 year-1) were studied for 7 seasons (1990/91-1996/97) on native range and on pasture over sown with fodder shrubs at Maragha, northwest Syria. There were 8 Awassi sheep in each stocking rate treatment, and the treatments were replicated 3 times in fenced paddocks. Milk yield, lamb production, live weight and supplementary feeding of the sheep were monitored. The results showed significantly higher forage availability on the range over-sown with fodder shrubs by 82% and 41% in the medium and high rainfall …

Feeds And Forages Intervention Strategies For Improved Livestock Nutrition And Productivity In The Northwest Highlands Of Vietnam, M. Atieno, T. B. N. Trần, V. T. Bùi, T. T. Mai, A. Duncan, S. Douxchamps, M. Peters

IGC Proceedings (1977-2023)

Livestock production in Vietnam is critical for livelihoods particularly for ethnic minorities in the Northwest Highlands (NWH). Improved livestock management and productivity can be achieved through better feed management and increased cultivation of improved forages, to meet animal nutrition demand. This study aimed at assessing feed intervention strategies to address context-specific feed-related challenges, mainly winter feed shortage in Mai Son district, Son La province, Vietnam. Feed interventions included promotion of improved forages (grasses and legumes) and capacity building on animal nutrition techniques including feed preservation, feed mix and feeding regimes for cattle and pigs. Willing farmers selected from a list …

Using A Walking Test To Assess Firefighter Fitness, Stephanie Donahue, Bilal Chaudhry, Carly Mcmorrow, Morgan Daly, Summer B. Cook, Michael Brian, Deborah L. Feairheller

International Journal of Exercise Science

International Journal of Exercise Science 17(4): 285-297, 2024. Tactical populations face increased risk on the job, and it is known that firefighters have high levels of cardiac-related death. Aerobic fitness is a modifiable cardiac risk factor, but many fire stations lack the proper equipment to easily assess aerobic fitness levels of their firefighters. Additionally, many fire stations lack wellness programs to hold firefighters accountable for maintaining their fitness levels. Purpose: We assessed the validity of the submaximal 6-minute walk test (6MWT) as a measure of aerobic capacity compared to a maximal treadmill test and the submaximal Gerkin protocol. Methods: Twenty-four …

Evaluation Of Novel Therapeutic Agents For The Treatment Of Chronic Dry Eyes, Lilian Huynh, Evonie Villarete, Surajit Dey

Annual Research Symposium

Dry eye disease (DED) is a multifactorial ocular condition, where disrupted tear film stability and ocular surface inflammation affected between 5% to 34% of the worldwide population in 2015 and posed a challenge to conventional ophthalmic treatments. Recent advances have led to potential novel therapeutics aiming to alleviate symptoms and improve patient outcomes.

Deep Retinal Layer Microvasculature Alterations In Schizophrenia, Samantha Fradkin, Deepthi Bannai, Paulo Lizano, Adriann Lai, Christen Crosta, Judy L. Thompson, Steven M. Silverstein

College of Science & Mathematics Departmental Research

A subset of individuals with schizophrenia (SZ) are thought to have a microvascular component to their illness with studies demonstrating alterations in retinal superficial, deep, and choroidal microvasculature networks. However, the direction and location of these alterations have differed across studies. In a recent study, we reported that individuals with SZ demonstrated lower superficial layer perfusion density than a healthy control (HC) group. The current study investigated characteristics of the deep vascular layer in SZ. We included 28 individuals with a diagnosis of SZ or schizoaffective disorder, and 37 HCs. Optical coherence tomography angiography (OCTA) data was collected to measure …

Increasing Workforce Skills: The Possible Disconnect Between Employers And Potential Job Seekers, Cheryl A. Burkhart-Kriesel

Cornhusker Economics

In a multi-year survey of potential job seekers, those who are likely to change jobs in the next year or who are likely to reenter the workforce in the next year, several key training obstacles for improving their employment situation were identified. There seemed to be only slight differences in how they viewed these challenges, regardless of whether they saw their potential job as a career, a steppingstone to a career, or just a job to get by. The cost of training, the lack of available training, the distance or transportation to the training, lack of time, and the knowledge …

Disruption Of The Sorghum Circadian Clock Impacts Sorghum-Sugarcane Aphid Interaction Dynamics And Aphid Feeding Behavior, Kumar Shrestha, Prince Zogli, Lise Pingault, Sajjan Grover, Juan Betancurt Cardona, Joe Louis

Department of Entomology: Faculty Publications

Circadian clocks play a pivotal role in orchestrating metabolic rhythms in response to environmental stress. Sorghum bicolor (sorghum), a multipurpose cereal crop, suffers severe growth and yield reduction due to feeding by sugarcane aphids (SCA; Melanaphis sacchari), which are phloem-feeding pests. Previously, it has been shown that sorghum utilizes a multitude of defense mechanisms to curb SCA colonization. However, our understanding of the impact of circadian clock on sorghum-aphid interaction dynamics is limited. To explore this, a time-series transcriptomics was conducted on sorghum plants in disrupted circadian rhythm with and without SCA infestation. Transcriptomic analysis revealed a total of …

Sense Of Place In Natural Resource Recreation And Tourism: An Evaluation And Assessment Of Research Findings.

The International Journal of Ecopsychology (IJE)

No abstract provided.

The Impact Of The Turkish Population Variome On The Genomic Architecture Of Rare Disease Traits, Ender Karaca, Tomasz Gambin, Tugce Bozkurt-Yozgatli, Shalini N Jhangiani, Donna M Muzny, Richard A Lewis, Pengfei Liu, Eric Boerwinkle, Ada Hamosh, Richard A Gibbs, V Reid Sutton, Nara Sobreira, Claudia M B Carvalho, Chad A Shaw, Jennifer E Posey, David Valle, James R Lupski

Faculty, Staff and Student Publications

PURPOSE: The variome of the Turkish (TK) population, a population with a considerable history of admixture and consanguinity, has not been deeply investigated for insights on the genomic architecture of disease.

METHODS: We generated and analyzed a database of variants derived from exome sequencing data of 773 TK unrelated, clinically affected individuals with various suspected Mendelian disease traits and 643 unaffected relatives.

RESULTS: Using uniform manifold approximation and projection, we showed that the TK genomes are more similar to those of Europeans and consist of 2 main subpopulations: clusters 1 and 2 (

CONCLUSION: Our findings support the notion that …

Sugar-Binding And Split Domain Combinations In Repeats-In-Toxin Adhesins From Vibrio Cholerae And Aeromonas Veronii Mediate Cell-Surface Recognition And Hemolytic Activities, Mustafa Sherik, Robert Eves, Shuaiqi Guo, Cameron J Lloyd, Karl E Klose

Faculty, Staff and Student Publications

Many pathogenic Gram-negative bacteria use repeats-in-toxin adhesins for colonization and biofilm formation. In the cholera agent Vibrio cholerae, flagellar-regulated hemagglutinin A (FrhA) enables these functions. Using bioinformatic analysis, a sugar-binding domain was identified in FrhA adjacent to a domain of unknown function. AlphaFold2 indicated the boundaries of both domains to be slightly shorter than previously predicted and assisted in the recognition of the unknown domain as a split immunoglobulin-like fold that can assist in projecting the sugar-binding domain toward its target. The AlphaFold2-predicted structure is in excellent agreement with the molecular envelope obtained from small-angle X-ray scattering analysis of …

Structural Insights Into The Molecular Mechanism Of High-Level Ceftazidime-Avibactam Resistance Conferred By Cmy-185, Akito Kawai, William C Shropshire, Masahiro Suzuki, Jovan Borjan, Samuel L Aitken, Christi L Mcelheny, Ryan K Shields, Samuel A Shelburne, Yohei Doi

Faculty, Staff and Student Publications

β-Lactamases can accumulate stepwise mutations that increase their resistance profiles to the latest β-lactam agents. CMY-185 is a CMY-2-like β-lactamase and was identified in an Escherichia coli clinical strain isolated from a patient who underwent treatment with ceftazidime-avibactam. CMY-185, possessing four amino acid substitutions of A114E, Q120K, V211S, and N346Y relative to CMY-2, confers high-level ceftazidime-avibactam resistance, and accumulation of the substitutions incrementally enhances the level of resistance to this agent. However, the functional role of each substitution and their interplay in enabling ceftazidime-avibactam resistance remains unknown. Through biochemical and structural analysis, we present the molecular basis for the enhanced …

Multifaceted Roles For Stat3 In Gammaherpesvirus Latency Revealed Through In Vivo B Cell Knockout Models, Chad H Hogan, Shana M Owens, Glennys V Reynoso, Yifei Liao, Thomas J Meyer, Bin Liu, Anna K Grosskopf, Camille Khairallah, Varvara Kirillov, Nancy C Reich, Brian S Sheridan, Kevin M Mcbride, Benjamin E Gewurz, Heather D Hickman, J Craig Forrest, Laurie T Krug

Faculty, Staff and Student Publications

Cancers associated with the oncogenic gammaherpesviruses, Epstein-Barr virus and Kaposi sarcoma herpesvirus, are notable for their constitutive activation of the transcription factor signal transducer and activator of transcription 3 (STAT3). To better understand the role of STAT3 during gammaherpesvirus latency and the B cell response to infection, we used the model pathogen murine gammaherpesvirus 68 (MHV68). Genetic deletion of STAT3 in B cells of CD19cre/+Stat3f/f mice reduced peak MHV68 latency approximately sevenfold. However, infected CD19cre/+Stat3f/f mice exhibited disordered germinal centers and heightened virus-specific CD8 T cell responses compared to wild-type (WT) littermates. To circumvent the systemic immune alterations observed in …

Drug Resistance Assessed In A Phase 3 Clinical Trial Of Maribavir Therapy For Refractory Or Resistant Cytomegalovirus Infection In Transplant Recipients, Sunwen Chou, Sophie Alain, Carlos Cervera, Roy F Chemaly, Camille N Kotton, Genovefa A Papanicolaou, Jingyang J Wu, Rose Ann Murray, Neil E Buss, Martha Fournier

Faculty, Staff and Student Publications

Background: This drug resistance analysis of a randomized trial includes 234 patients receiving maribavir and 116 receiving investigator-assigned standard therapy (IAT), where 56% and 24%, respectively, cleared cytomegalovirus DNA at week 8 (treatment responders).

Methods: Baseline and posttreatment plasma samples were tested for mutations conferring drug resistance in viral genes UL97, UL54, and UL27.

Results: At baseline, genotypic testing revealed resistance to ganciclovir, foscarnet, or cidofovir in 56% of patients receiving maribavir and 68% receiving IAT, including 9 newly phenotyped mutations. Among them, 63% (maribavir) and 21% (IAT) were treatment responders. Detected baseline maribavir resistance mutations were UL27 L193F (n …

The Il6/Jak/Stat3 Signaling Axis Is A Therapeutic Vulnerability In Smarcb1-Deficient Bladder Cancer, Danthasinghe Waduge Badrajee Piyarathna, Lacey Elizabeth Dobrolecki, David J H Shih, Zhongcheng Shi, Jun Xu, Shixia Huang, Matthew J Ellis, Andrea B Apolo, Leomar Y Ballester, Jianjun Gao, Donna E Hansel, Yair Lotan, H Courtney Hodges, Seth P Lerner, Chad J Creighton, Arun Sreekumar, W Jim Zheng, Pavlos Msaouel, Shyam M Kavuri, Nagireddy Putluri

Faculty, Staff and Student Publications

SMARCB1 loss has long been observed in many solid tumors. However, there is a need to elucidate targetable pathways driving growth and metastasis in SMARCB1-deficient tumors. Here, we demonstrate that SMARCB1 deficiency, defined as genomic SMARCB1 copy number loss associated with reduced mRNA, drives disease progression in patients with bladder cancer by engaging STAT3. SMARCB1 loss increases the chromatin accessibility of the STAT3 locus in vitro. Orthotopically implanted SMARCB1 knockout (KO) cell lines exhibit increased tumor growth and metastasis. SMARCB1-deficient tumors show an increased IL6/JAK/STAT3 signaling axis in in vivo models and patients. Furthermore, a pSTAT3 selective inhibitor, TTI-101, reduces …

Exploring The Developmental Effects Of Antidepressants In Caenorhabditis Elegans, Alexandra Van Stone

Annual Research Symposium

It is so important to explore the potential side effects of antidepressants especially if these side effects could lead to a future detriment to an individual’s financial and social well-being. A better understanding of these side effects in regards to human developmental issues is imperative considering issues related to mental health and depression affect a large percentage of the population. In this study, we tested if Caenorhabditis (C.) elegans could be a potential model organism to predict possible side effects associated with select antidepressants. Their developmental problems potentially encountered upon drug treatment may be encountered in humans.

Long Non-Coding Rna As A Potential Diagnostic Tool In Coronary Artery Diseases - A Systematic Review, Arthi Sri A.S, Vishnu Priya Veeraraghavan

Annual Research Symposium

POSTER - SYSTEMATIC REVIEW - LONG NON CODING RNAS AS DIAGNOSTIC MARKER FOR CAD

Correlation Between Salivary Levels And Tissue Expression Status Of Her2 In Breast Cancer Patients - A Cross-Sectional Study, Arthi Sri A.S, Massillamani F, Vinothkumar Thilla Sekar

Annual Research Symposium

The study aims to investigate if soluble salivary human epidermal growth factor receptor-2 (HER2) would play a role in the diagnosis of breast cancer patients and also to find out the influence of demographic and hormonal factors on the salivary HER2 levels in breast cancer.

Investigating Optimal Laboratory Growth Conditions Of Gracilibacillus Halotolerans In Media Supplemented With Salt, Isaac Young

Annual Research Symposium

As interest continues to grow in the field of persister cells and their morphology, there arises an ever-evolving desire to further understand specific strains of bacteria that exemplify the qualities of seemingly anomalous survival regardless of anti-bacterial treatment. In the case of the Gracilibacillus halotolerans, a halotolerant extremophile extracted from the Great Salt Lake with known persistent characteristics, uncovering its optimal growth conditions was essential for future investigations. Identifying the optimal salinity for the growth of G. halotolerans will allow us to standardize our growth methods, uncover several mechanisms of saline tolerance, and add to future investigations of persistence with …

Interplay Of Periodontal Bacterial Metabolites In The Progression Of Coronary Artery Disease: A System Biological Approach, Janakiraman V

Annual Research Symposium

Purpose:

The purpose of this study is to investigate the intricate relationship between periodontal disease (PD) and coronary artery disease (CAD), as evidenced by epidemiological associations. Metalloproteinase inhibitor (TIMP1) plays a pivotal role in cellular signaling, differentiation, cell death, and migration by binding to target metalloproteinases, forming complexes with other molecules (collagenases) to inactivate them. However, the expression of TIMP1 is reduced in both PD and CAD, leading to an upregulation of other metalloproteinases. This research explores the hypothesis that metabolites released from (Porphyromonas gingivalis), a prevalent bacterium in atherosclerotic patients, may inhibit TIMP1, thereby influencing CAD progression. …

Sulforaphane Pre-Treatment Improves Cytoprotection Against Opportunistic Pathogens, Robert Darby, Nathan Clark

Annual Research Symposium

Alcohol is associated with increased mortality and morbidity globally. Pulmonary infections with opportunistic pathogens can occur in healthy humans; however, binge alcohol intoxication (≥ 0.08% BAC) is a major risk factor. We have previously shown that a single dose of alcohol comparable to binge alcohol intoxication increases infection by reducing alveolar macrophage function in vivo. The aim of this study was to 1) test the therapeutic potential of the phytonutrient sulforaphane (SFN) given as a pre-treatment, and 2) test the alcohol-induced effects on phagocytic function in murine and human macrophages in vitro.

Investigating The Impact Of Ozempic Treatment On Alcohol Consumption In Individuals With Class 1 And Class 2 Obesity, Yvannia Gray, Selin Karadag

Annual Research Symposium

The purpose of this experiment is to see if there is a correlation between Ozempic (semaglutide) treatment for weight loss and alcohol consumption. Ozempic is a glucagon-like peptide-1 (GLP-1) agonist that lowers blood sugar and appetite as it mimics the effects of GLP-1. In previous studies involving rodents, it has been shown that GLP-1 agonists can also be used to reduce addictive substance intake. We hypothesize that subjects who receive Ozempic treatment will exhibit reduced consumption of alcohol over the span of a month compared to subjects who do not receive Ozempic treatment.

The Problem Of Communication Of The Sign And Symbol In The Design Of The Brand In Society: The Differences Resulting From Forgery And Imitation (Analytical Study), Sattar Al-Juboori

The research problem focused on studying the consequences of communicating through signs and symbols in the context of the current world, given the huge amount of diverse industrial and commercial products and the challenges related to distinguishing those products. The research aims to find out the problem of perception of the sign and symbol in the designs of logos and trademarks for the consumer, the role that the sign or symbol plays in the symbolic representation of the consumer, and the desires and motivations that the brand raises for the consumer in the purchasing process. The research community is limited …

Impairment Of The Glial Phagolysosomal System Drives Prion-Like Propagation Of Huntington’S Disease, Graham Davis

Theses and Dissertations

The ability of glia to tightly regulate neuronal health and homeostasis in the CNS is conserved across species. Yet, despite the ability to degrade protein aggregates, glia are vulnerable to the accumulation of neurotoxic amyloid aggregates during neurodegenerative disease progress, and even exacerbate their spread. A developing narrative highlights glia as a double-edged sword in neurodegenerative diseases: initially capable of dynamically responding to amyloid aggregate-ladened dying neurons but also capable of inducing chronic inflammation and creating seeding-competent amyloid oligomers. Thus, uncovering the mechanisms that allow glia to control aggregate deposition while preventing the neurotoxic effects and seed generation is vital …

Relationship Of Tissue Dimensions And Three Captive Bolt Application Sites On Cadaver Heads From Mature Swine (Sus Scrofa Domesticus) < 200 Kg Body-Weight, Karly N. Anderson, Ashlynn A. Kirk, Jennifer Berger, Arquimides A. Reyes, Ruth Woiwode, Perle E. Zhitnitskiy, Kurt D. Vogel

Department of Animal Science: Faculty Publications

Penetrating captive bolt (PCB) is a common method of euthanasia for swine but has not been evaluated for mature swine < 200 kg body weight (BW). The objectives were to determine tissue depth, brain contact plane, and visible brain tissue damage (brain damage[BD]) for the common FRONTAL (F) and alternative TEMPORAL (T) and BEHIND EAR (BE) placements for PCB use on sows and boars weighing < 200 kg. Cadaver heads were obtained from 30 sows and 30 boars (estimated BW, mean ± SD; sows: 165.8 ± 22.4 kg; boars: 173.6 ± 21.4 kg) from a slaughter establishment after electrical stunning and exsanguination. Heads were cooled at 2 to 4 °C for approximately 64 h. A Jarvis PAS-Type P 0.25R PCB with a Long Stunning Rod Nosepiece Assembly and a 3.5 GR power load was used for all PCB applications at the following placements: F–3.5 cm superior to the optic orbits at midline, T–at the depression posterior to the lateral canthus of the eye within the plane between the lateral canthus and the base of the ear, or BE–directly caudal to the pinna of the ear on the same plane as the eyes and targeting the middle of the opposite eye. For sows, the bolt path was in the brain for 10/10 (100.0%, 95% CI: 69.2% to 100.0%) F, T, and BE heads. In heads that could reliably be assessed for BD, BD was detected in 10/10 (100.0%, 95% CI: 69.2% to 100.0%) F heads, 9/9 (100.0%, 95% CI: 66.4% to 100.0%) T heads, and 0/10 (0.0%, 95% CI: 0.0% to 30.1%) BE heads. For boars, the bolt path was in the plane of the brain for 8/9 (88.9%, 95% CI: 51.8% to 99.7%) F heads, 9/10 (90.0%, 95% CI: 55.5% to 99.7%) T heads, and 11/11 (100.0%, 95% CI: 71.5% to 100.0%) BE heads. In heads that could reliably be assessed for BD, BD was detected in 8/9 (88.9%, 95% CI: 51.7% to 99.7%) F heads, 7/10 (70.0%, 95% CI: 34.8% to 93.3%) T heads, and 4/11 (36.4%, 95% CI: 10.9% to 69.2%) BE heads. Tissue depth was reported as mean ± SE followed by 95% one-sided upper reference limit (URL). For sows, total tissue thickness differed (P < 0.05) between placements (F: 49.41 ± 2.74 mm, URL: 70.0 mm; T: 62.83 ± 1.83 mm, URL: 76.6 mm; BE: 84.63 ± 3.67 mm; URL: 112.3 mm). Total tissue thickness differed (P < 0.05) between placements for boars (F: 54.73 ± 3.23 mm, URL: 77.6 mm; T: 70.72 ± 3.60 mm, URL: 96.3 mm; BE: 92.81 ± 5.50 mm; URL: 135.3 mm). For swine between 120 and 200 kg BW, the F placement may have the greatest likelihood for successful euthanasia due to the least total tissue thickness and may present less risk for failure than the T and BE placements.

U.S. Cereal Rye Winter Cover Crop Growth Database, Alexandra M. Huddell, Resham Thapa, Guillermo S. Marcillo, Lori J. Abendroth, Victoria J. Ackroyd, Shalamar D. Armstrong, Gautam Asmita, Muthukumar V. Bagavathiannan, Kipling S. Balkcom, Andrea Basche, Shawn Beam, Kevin Bradley, Lucas Pecci Canisares, Heather Darby, Adam S. Davis, Pratap Devkota, Warren A. Dick, Jeffery A. Evans, Wesley J. Everman, Tauana Ferreira De A Lmeida, Michael L. Flessner, Lisa M. Fultz, Stefan Gailans, Masoud Hashemi, Joseph Haymaker, Matthew J. Helmers, Nicholas Jordan, Thomas C. Kaspar, Quirine M. Ketterings, Eileen Kladivko, Alexandra Kravchenko, Eugene P. Law, Lauren Lazaro, Ramon G. Leon, Jeffrey Liebert, John Lindquist, Kristen Loria, Jodie M. Mcvane, Jarrod O. Miller, Michael J. Mulvaney, Nsalambi V. Nkongolo, Jason K. Norsworthy, Binaya Parajuli, Christopher Pelzer, Cara Peterson, Hanna Poffenbarger, Pratima Poudel, Mark S. Reiter, Matt Ruark, Matthew R. Ryan, Spencer Samuelson, John E. Sawyer, Sarah Seehaver, Lovreet S. Shergill, Yogendra Raj Upadhyaya, Mark Vangessel, Ashley L. Waggoner, John M. Wallace, Samantha Wells, Charles White, Bethany Wolters, Alex Woodley, Rongzhong Ye, Eric Youngerman, Brian A. Needelman, Steven B. Mirsky

Department of Agronomy and Horticulture: Faculty Publications

Winter cover crop performance metrics (i.e., vegetative biomass quantity and quality) affect ecosystem services provisions, but they vary widely due to differences in agronomic practices, soil properties, and climate. Cereal rye (Secale cereale) is the most common winter cover crop in the United States due to its winter hardiness, low seed cost, and high biomass production. We compiled data on cereal rye winter cover crop performance metrics, agronomic practices, and soil properties across the eastern half of the United States. The dataset includes a total of 5,695 cereal rye biomass observations across 208 site-years between 2001–2022 and encompasses …

Protecting Human And Animal Health: The Road From Animal Models To New Approach Methods, Emanuela Corsini, Sonya K Sobrian, Suzanne C Fitzpatrick, Marcia H Ratner, Donna L Mendrick

Faculty, Staff and Student Publications

Animals and animal models have been invaluable for our current understanding of human and animal biology, including physiology, pharmacology, biochemistry, and disease pathology. However, there are increasing concerns with continued use of animals in basic biomedical, pharmacological, and regulatory research to provide safety assessments for drugs and chemicals. There are concerns that animals do not provide sufficient information on toxicity and/or efficacy to protect the target population, so scientists are utilizing the principles of replacement, reduction, and refinement (the 3Rs) and increasing the development and application of new approach methods (NAMs). NAMs are any technology, methodology, approach, or assay used …