Life Sciences Commons^™

Effects Of Different Production Systems On The Nutrient Density Of Beef, T. Statham, J. Cloward, N. Evans, S. Van Vliet

IGC Proceedings (1977-2023)

As concerns regarding beef production systems on human health and animal welfare become more apparent, consumer interest in pasture-raised livestock has been steadily on the rise in the US. Such interest has increasingly led to questions about potential nutritional composition differences in beef from different production systems, such as grass-fed beef and grain-fed beef. The goal of this work was to conduct untargeted metabolomics analysis on a broad range of samples from the US beef supply chain to provide insight into how different finishing systems impact the beef metabolome and nutrient density. Here, we found that 191 out of 802 …

Impacts Of Forage Cropping Decisions On Feed-Flows In Cool- Temperate Grazing Systems, D. R. Stevens, M. J. Casey

IGC Proceedings (1977-2023)

Intensive cool-temperate grasslands often rely on adding forage crops to help supply feed when pasture growth is limited by cool temperatures and low sunlight. We tested the impacts of using single- or multi-graze crops to alter feed supply in either summer/autumn or winter on productivity in red deer farming systems in a cool-temperate environment. The choice of single-graze or multi-graze crops to provide forage in deer grazing systems had an impact on the feed flows and the amount of pasture available, with multi-graze crops supplying more feed during the dry summer months while single-graze crops supplying more feed during the …

Challenges And Opportunities For Sustainable Livestock Production In The Context Of Socioeconomic And Food Security In Northern Areas Of Pakistan, Muhammad Tariq

IGC Proceedings (1977-2023)

Due to a variety of biophysical and socioeconomic variables, food insecurity in Pakistan is noticeably higher in the mountainous areas than in the plains. In the Hindu Kush-Himalayan region, the issue of food insecurity made worse by rapid socio-economic and environmental changes as well as topographical constraints. In northern areas of Pakistan livestock is raised for many purposes, including milk, meat, wool, leather, and draft. The livestock not only contributes significantly to the region's food security but also a sizable portion of what local families eat on a daily basis at their food table. Livestock are raised using nomadic and …

Yak (Bos Grunniens): The Mammal Of Socio-Economic Importance In Gilgit- Baltistan, Pakistan, Muhammad Tariq, Asif Hameed

IGC Proceedings (1977-2023)

The yaks are long-haired humped bovid, a multipurpose animal that can survive in a low oxygen and cold environment at an elevation of 2000 to 6000 meters above sea level. The animal has the ability to graze diverse foliage from coarse shrubs to short grasses. The majority of yak population is still living in central Asian highlands, which include parts of Tibet, China, Indo-Pak. Yak rearing in Pakistan is bounded to higher elevations (3,500–4,500 meters a.s.l) of Gilgit-Baltistan (GB) and Chitral, where yak is important and places the only means of livelihood through theprovision of milk, meat, and wool, hairs …

Integrated Crop And Pasture Based Livestock Production System Success On Reclaimed Surface Coal Mined Land In South Africa, W. F. Truter, E. N. Cele

IGC Proceedings (1977-2023)

Coal mining is the largest surface mining operation in South Africa’s grassland biome. Surface mining is leaving large tracts of land revegetated to pasture species as mining companies attempt to reclaim the agricultural potential of mined areas. Top soil management remains the key challenge to ensure agricultural productivity. During the reclamation process, newly placed soils are very often chemically, physically and microbiologically degraded, and high soil ameliorant inputs are required to catalyse agroecosystem function. These revegetated landscapes can offer good grazing capacity; however, to date there are no livestock grazing these areas, resulting in the subsequent deterioration of these new …

Grazing And Animal Welfare Of Dairy Cows In Europe, What Do We Know?, A. Van Den Pol-Van Dasselaar, D. Hennessy, J. Isselstein

IGC Proceedings (1977-2023)

Grazing systems are important components of the landscape in almost all European countries. Grazing is inherently close to the nature of herbivores, but no longer applied everywhere in Europe. This paper discusses the extent of dairy cow grazing in Europe and the effect of grazing on animal welfare. The study builds on results of surveys from the European Grassland Federation (EGF) Working Group “Grazing” (WGG) in the period 2010–2022 and a focus group meeting in 2022. Data on the extent of grazing of dairy cows in Europe are provided. Europe can be divided into six distinctive regions with respect to …

Diurnal Variation In Forage Nutrient Composition And Metabolic Parameters Of Horses Grazing Warm-Season, Perennial Grass-Legume Mixed Pastures, A. C. Vasco, J. Dubeux, L. Sollenberger, M. Wallau, E. Santos, J. Lance, L. Warren, C. Wickens

IGC Proceedings (1977-2023)

Although warm-season, grass-legume mixed pastures have improved nutritive value and may reduce negative environmental impacts relative to nitrogen-fertilized grass monocultures, no study has been done to evaluate their effect on diurnal variation of non-structural carbohydrates (NSC) and other nutrients, and on the metabolic responses observed in horses’ blood and fecal samples. This 2-yr study aimed to investigate the circadian variation in nutrient composition and the fecal and blood metabolic responses in horses grazing these pastures. Forage, fecal, and blood samples were collected every 28 days at 0600, 1200, 1800, and 0000 h, in two years, for measurement of diurnal variation …

Herbage Responses And Performance Of Mature Horses Grazing Warm-Season Perennial Grass-Legume Mixed Pastures, A. C. Vasco, E. R. Santos, J. Lance, J. Dubeux, L. Sollenberger, M. Wallau, C. Wickens, L. Warren

IGC Proceedings (1977-2023)

Legume-grass mixtures may be a useful alternative to nitrogen-fertilized grass monocultures, but pasture and animal responses have not been assessed for pastures grazed by horses in Florida. This 2-yr study compared pasture and horse responses of continuously stocked, mixed pastures of rhizoma peanut (RP, Arachis glabrata Benth) and bahiagrass (BG, Paspalum notatum Flüggé) receiving 30 kg nitrogen (N)/ha (RP-BG) compared with BG pastures fertilized with 120 kg/N ha (BG-N) or with no N (BG-No N). Herbage mass was similar among treatments in 2020 and for most evaluation days in 2019. In 2019, stocking rate (AU/ha) was greater in …

Integrating Plant Secondary Metabolites And Foraging Behavior To Enhance Animal Health In Ruminant Production Systems, J. J. Villalba, J. W. Macadam, S. Van Vliet, F. D. Provenza

IGC Proceedings (1977-2023)

Legumes and forbs contain bioactives or plant secondary compounds (PSC) with potential to enhance animal health through their antibiotic, antioxidant and immunomodulatory properties that are evident even at small dietary concentrations. In turn, ruminants can regulate their ingestion of PSC through behavioral mechanisms that allow for the efficient achievement of homeostasis. High concentrations of PSC lead to food avoidance, whereas lower content of PSC in the diet achieved through regulatory mechanisms of ingestion could promote medicinal and/or prophylactic effects in the animal and concomitant health benefits to milk and meat products. Under this context, we discuss the restructuring of rangelands …

The Effect Of Spring Grass Availability On Dry Matter Intake Of Early Lactation Dairy Cows, S. Walsh, Z. C. Mckay, M. Egan

IGC Proceedings (1977-2023)

Spring grass availability has a major impact on dry matter intake (DMI) of dairy cows during early lactation. The objective of this study was to investigate the effects of opening farm cover (OFC) on DMI during early lactation. A twelve week experiment, which was split into two 6 week periods (Period 1 (Week 1 – 6) and period 2 (Week 7 – 12), was conducted over a two year period. A high and low OFC were established for two treatment groups; 1253 kg DM/ha (High grass = HG) and 887 kg DM/ha (Low grass = LG). Animals were randomly assigned …

Effects Of Stocking Rates On Water Use Efficiency Of Established Species In Stipa Breviflora Desert Steppe, M. Zhao, G. M. Yin, S. B. Liu, W. J. Meng

IGC Proceedings (1977-2023)

Plant water use efficiency reflects the survival adaptation strategies adopted by plants to obtain maximum carbon harvest. Understanding the water and resource utilization strategies of Stipa breviflora in desert steppe will help people understand its growth mechanism, and it is of great significance to analyze the ecological countermeasures of Stipa breviflora to cope with disturbance. In this study, the water use efficiency (WUE) of the established populations of Stipa breviflora in desert steppe was measured by stable carbon isotope method and photosynthometer method, and the adaptation mechanism of Stipa breviflora under different stocking rates was discussed based on the basic …

The Hindgut Microbiome Of Grazing Horses, J. R. Weinert, C. A. Williams

IGC Proceedings (1977-2023)

The hindgut microbiome plays an essential role in horses consuming forage-based diets high in fiber, such as pasture. The equine hindgut harbors a large microbial community that ferments dietary fiber and produces by-products which provide a substantial portion of daily energy requirements. Despite the importance in nutrition and health, research evaluating the hindgut microbiome of grazing horses is relatively limited. Grazing horse microbiome research has primarily focused on inter-diet comparisons with mixed diets including concentrates as well as with other forms of forage. Recent research has begun to explore responses of the gut microbiome to different pasture forage species and …

Horse And Pasture Responses To Stocking Methods: Rotational Versus Continuous, C. A. Williams, J. R. Weinert-Nelson

IGC Proceedings (1977-2023)

Rotational grazing management offers potential advantages for economic and environmental sustainability, as well as for horse health. Rotational grazing has the potential to increase pasture yields and available forage for grazing, and therefore reduce supplemental feed costs. A rotational grazing management strategy can also prevent or mitigate negative effects of overgrazing, with implications for pasture productivity and the environment. Overgrazing can reduce vegetative cover over time, increasing the potential for erosion and nutrient run-off. Overgrazing may also result in long-term decreased forage stand persistence and weed invasion, necessitating more frequent pasture renovation. All of this can negatively impact the horse’s …

The Santa Clara, 2024-02-16, Santa Clara University

The Santa Clara

No abstract provided.

Strategies To Combine 3d Vasculature And Brain Cta With Deep Neural Networks: Application To Lvo, Luca Giancardo

Faculty, Staff and Student Publications

Automated tools to detect large vessel occlusion (LVO) in acute ischemic stroke patients using brain computed tomography angiography (CTA) have been shown to reduce the time for treatment, leading to better clinical outcomes. There is a lot of information in a single CTA and deep learning models do not have an obvious way of being conditioned on areas most relevant for LVO detection, i.e., the vasculature structure. In this work, we compare and contrast strategies to make convolutional neural networks focus on the vasculature without discarding context information of the brain parenchyma and propose an attention-inspired strategy to encourage this. …

Generalizable Pipeline For Constructing Hiv Risk Prediction Models Across Electronic Health Record Systems

Faculty, Staff and Student Publications

OBJECTIVE: The HIV epidemic remains a significant public health issue in the United States. HIV risk prediction models could be beneficial for reducing HIV transmission by helping clinicians identify patients at high risk for infection and refer them for testing. This would facilitate initiation on treatment for those unaware of their status and pre-exposure prophylaxis for those uninfected but at high risk. Existing HIV risk prediction algorithms rely on manual construction of features and are limited in their application across diverse electronic health record systems. Furthermore, the accuracy of these models in predicting HIV in females has thus far been …

Achieving Wheat Self-Sufficiency In Brazil, Rogerio De S. Noia Junior, Maicon Nardino, Elvis F. Elli, Diego Pequeno, Clyde Fraisse

Crop, Soil and Environmental Sciences Faculty Publications and Presentations

Brazil is a leading grain producer and exporter, producing on average 6.6 million tons (Mt) of wheat per year from 2013 to 2023. However, to meet its average annual domestic consumption of 11.1 Mt over the same period, the country continued to rely on imports of 4.5 Mt of wheat each year. This dependency on imports leads to high wheat prices in Brazil compared to the global average.

Development Of A Practical Nomogram For Personalized Anemia Management In Patients Treated With Ataxia Telangiectasia And Rad3-Related Inhibitor Camonsertib, Ezra Rosen, Timothy A Yap, Elizabeth K Lee, Martin Højgaard, Niharika B Mettu, Benedito A Carneiro, Adrian J Fretland, Danielle Ulanet, Yi Xu, Robin Mcdougall, Maria Koehler, Elisa Fontana

Faculty, Staff and Student Publications

PURPOSE: Camonsertib is a highly selective and potent inhibitor of ataxia telangiectasia and Rad3-related (ATR) kinase. Dose-dependent anemia is a class-related on-target adverse event often requiring dose modifications. Individual patient risk factors for the development of significant anemia complicate the selection of a "one-size-fits-all" ATR inhibitor (ATRi) dose and schedule, possibly leading to suboptimal therapeutic doses in patients at low risk of anemia. We evaluated whether early predictors of anemia could be identified to ultimately inform a personalized dose-modification approach.

PATIENTS AND METHODS: On the basis of preclinical observations and a mechanistic understanding of ATRi-related anemia, we identified several potential …

Mutant P53 Protects Triple-Negative Breast Adenocarcinomas From Ferroptosis In Vivo, Denada Dibra, Shunbin Xiong, Sydney M Moyer, Adel K El-Naggar, Yuan Qi, Elisabeth K Kong, Guillermina Lozano

Faculty, Staff and Student Publications

The TP53 tumor suppressor gene is mutated early in most of the patients with triple-negative breast cancer (TNBC). The most frequent TP53 alterations are missense mutations that contribute to tumor aggressiveness. Here, we used an autochthonous somatic TNBC mouse model, in which mutant p53 can be toggled on and off genetically while leaving the tumor microenvironment intact and wild-type for p53 to identify physiological dependencies on mutant p53. In TNBCs that develop in this model, deletion of two different hotspot p53R172H and p53R245W mutants triggers ferroptosis in vivo, a cell death mechanism involving iron-dependent lipid peroxidation. Mutant p53 protects cells …

Sting Licensing Of Type I Dendritic Cells Potentiates Antitumor Immunity, Jian Wang, Suxin Li, Maggie Wang, Xu Wang, Shuqing Chen, Xiubao Ren, Baran D Sumer, Nan Yan, Yang-Xin Fu, Jinming Gao

Faculty, Staff and Student Publications

Stimulator of interferon genes (STING) is an immune adaptor protein that senses cyclic GMP-AMP (cGAMP) in response to self or microbial cytosolic DNA as a danger signal. STING is ubiquitously expressed in diverse cell populations including cancer cells with distinct cellular functions such as activation of type I interferons, autophagy induction, or triggering apoptosis. It is not well understood whether and which subsets of immune cells, stromal cells, or cancer cells are particularly important for STING-mediated antitumor immunity. Here using a polymeric STING-activating nanoparticle (PolySTING) with a “shock-and-lock” dual activation mechanism, we show type 1 conventional dendritic cell (cDC1) is …

Circulating Microrna Panel For Prediction Of Recurrence And Survival In Early-Stage Lung Adenocarcinoma, Mei-Chee Tai, Leonidas E Bantis, Gargy Parhy, Taketo Kato, Ichidai Tanaka, Junya Fujimoto, Tetsunari Hase, Koji Kawaguchi, Johannes F Fahrmann, Edwin J Ostrin, Kohei Yokoi, Toyofumi F Chen-Yoshikawa, Yoshinori Hasegawa, Samir M Hanash, Ignacio I Wistuba, Ayumu Taguchi

Faculty, Staff and Student Publications

Early-stage lung adenocarcinoma (LUAD) patients remain at substantial risk for recurrence and disease-related death, highlighting the unmet need of biomarkers for the assessment and identification of those in an early stage who would likely benefit from adjuvant chemotherapy. To identify circulating miRNAs useful for predicting recurrence in early-stage LUAD, we performed miRNA microarray analysis with pools of pretreatment plasma samples from patients with stage I LUAD who developed recurrence or remained recurrence-free during the follow-up period. Subsequent validation in 85 patients with stage I LUAD resulted in the development of a circulating miRNA panel comprising miR-23a-3p, miR-320c, and miR-125b-5p and …

Long Trimer-Immunization Interval And Appropriate Adjuvant Reduce Immune Responses To The Soluble Hiv-1-Envelope Trimer Base, Hongying Duan, Angela R Corrigan, Cheng Cheng, Andrea Biju, Christopher A Gonelli, I-Ting Teng, Sijy O'Dell, Sandeep Narpala, Mike Castro, Leonid Serebryannyy, Jennifer Wang, Danealle K Parchment, Edward K Sarfo, Jelle Van Schooten, John-Paul Todd, Shuishu Wang, Darcy R Harris, Hui Geng, Alexander J Jafari, Vrc Production Program, Ruth A Woodward, Nicole A Doria-Rose, Kathryn E Foulds, Adrian B Mcdermott, Marit J Van Gils, Richard A Koup, Theodore C Pierson, Peter D Kwong, John R Mascola

Faculty, Staff and Student Publications

Soluble 'SOSIP'-stabilized HIV-1 envelope glycoprotein (Env) trimers elicit dominant antibody responses targeting their glycan-free base regions, potentially diminishing neutralizing responses. Previously, using a nonhuman primate model, we demonstrated that priming with fusion peptide (FP)-carrier conjugate immunogens followed by boosting with Env trimers reduced the anti-base response. Further, we demonstrated that longer immunization intervals further reduced anti-base responses and increased neutralization breadth. Here, we demonstrate that long trimer-boosting intervals, but not long FP immunization intervals, reduce the anti-base response. Additionally, we identify that FP priming before trimer immunization enhances antibody avidity to the Env trimer. We also establish that adjuvants Matrix …

Serum Biomarker Signature Is Predictive Of The Risk Of Hepatocellular Cancer In Patients With Cirrhosis, Hashem El-Serag, Fasiha Kanwal, Jing Ning, Hannah Powell, Saira Khaderi, Sumeet Asrani, Christopher I Amos, Aaron P Thrift, Michelle Luster, Abeer Alsarraj, Luis Olivares, Darlene Skapura, Jenny Deng, Emad Salem, Omar Najjar, Xian Yu, Hao Duong, Michael E Scheurer, Christie M Ballantyne, Salma Kaochar

Faculty, Staff and Student Publications

BACKGROUND: Inflammatory and metabolic biomarkers have been associated with hepatocellular cancer (HCC) risk in phases I and II biomarker studies. We developed and internally validated a robust metabolic biomarker panel predictive of HCC in a longitudinal phase III study.

METHODS: We used data and banked serum from a prospective cohort of 2266 adult patients with cirrhosis who were followed until the development of HCC (n=126). We custom designed a FirePlex immunoassay to measure baseline serum levels of 39 biomarkers and established a set of biomarkers with the highest discriminatory ability for HCC. We performed bootstrapping to evaluate the predictive performance …

A Small Molecule With Big Impact: Mrtx1133 Targets The Krasg12d Mutation In Pancreatic Cancer, Daoyan Wei, Liang Wang, Xiangsheng Zuo, Anirban Maitra, Robert S Bresalier

Faculty, Staff and Student Publications

KRAS mutations drive oncogenic alterations in numerous cancers, particularly in human pancreatic ductal adenocarcinoma (PDAC). About 93% of PDACs have KRAS mutations, with G12D (∼42% of cases) and G12V (∼32% of cases) being the most common. The recent approval of sotorasib (AMG510), a small-molecule, covalent, and selective KRASG12C inhibitor, for treating patients with non-small cell lung cancer represents a breakthrough in KRAS targeted therapy. However, there is a need to develop other much-needed KRAS-mutant inhibitors for PDAC therapy. Notably, Mirati Therapeutics recently developed MRTX1133, a small-molecule, noncovalent, and selective KRASG12D inhibitor through extensive structure-based drug design. MRTX1133 has demonstrated potent …

Backfilling Patients In Phase I Dose-Escalation Trials Using Bayesian Optimal Interval Design (Boin), Yixuan Zhao, Ying Yuan, Edward L Korn, Boris Freidlin

Faculty, Staff and Student Publications

In recent years, there has been increased interest in incorporation of backfilling into dose-escalation clinical trials, which involves concurrently assigning patients to doses that have been previously cleared for safety by the dose-escalation design. Backfilling generates additional information on safety, tolerability, and preliminary activity on a range of doses below the maximum tolerated dose (MTD), which is relevant for selection of the recommended phase II dose and dose optimization. However, in practice, backfilling may not be rigorously defined in trial protocols and implemented consistently. Furthermore, backfilling designs require careful planning to minimize the probability of treating additional patients with potentially …

Neoadjuvant Trebananib Plus Paclitaxel-Based Chemotherapy For Stage Ii/Iii Breast Cancer In The Adaptively Randomized I-Spy2 Trial-Efficacy And Biomarker Discovery, Kathy S Albain, Christina Yau, Emanuel F Petricoin, Denise M Wolf, Julie E Lang, Tufia Haddad, Anne M Wallace, Henry Kaplan, Lajos Pusztai, David Euhus, Rita Nanda, Anthony D Elias, Amy S Clark, Constantine Godellas, Judy C Boughey, Claudine Isaacs, Debu Tripathy, Janice Lu, Rachel L Yung, Rosa I Gallagher, Julia D Wulfkuhle, Lamorna Brown-Swigart, Gregor Krings, Yunn Yi Chen, David A Potter, Erica Stringer-Reasor, Sarah Blair, Smita M Asare, Amy Wilson, Gillian L Hirst, Ruby Singhrao, Meredith Buxton, Julia L Clennell, Ashish Sanil, Scott Berry, Adam L Asare, Jeffrey B Matthews, Angela M Demichele, Nola M Hylton, Michelle Melisko, Jane Perlmutter, Hope S Rugo, W Fraser Symmans, Laura J Van't Veer, Douglas Yee, Donald A Berry, Laura J Esserman

Faculty, Staff and Student Publications

Purpose: The neutralizing peptibody trebananib prevents angiopoietin-1 and angiopoietin-2 from binding with Tie2 receptors, inhibiting angiogenesis and proliferation. Trebananib was combined with paclitaxel±trastuzumab in the I-SPY2 breast cancer trial.

Patients and methods: I-SPY2, a phase II neoadjuvant trial, adaptively randomizes patients with high-risk, early-stage breast cancer to one of several experimental therapies or control based on receptor subtypes as defined by hormone receptor (HR) and HER2 status and MammaPrint risk (MP1, MP2). The primary endpoint is pathologic complete response (pCR). A therapy "graduates" if/when it achieves 85% Bayesian probability of success in a phase III trial within a given subtype. …

Study On The Chemical Composition And Antioxidant Activities Of Essential Oil Extracted From Horwoodia Dicksoniae Growing In The Uae, Salama Sari Almansoori

Thesis/ Dissertation Defenses

Plant-derived substances including essential oils, secondary metabolites and other chemical substances are gaining attention due to their broad spectrum use in different fields. Native medicinal plants can play key role in healthcare field in any country. Horwoodia dicksoniae is a native endangered plant in UAE. Current study is about chemical composition and antioxidant properties of H. dicksoniae’s essential oil as well as evaluating growth of this native endangered plant under different environmental conditions. For this purpose, first step included confirmation of the viability of seeds obtained from a seed bank following germination of seeds in different media. During growth period …

Investigating The Phytochemicals In Sargassum (Brown Algae) Against The Therapeutic Targets Of Oral Squamous Cell Carcinoma Metastasized From Breast: An Approach, Mahema S

Annual Research Symposium

ABSTRACT:

Purpose: Oral metastases are relatively rare. In women, the most common oral metastases originate from breast cancer, the most diagnosed malignancy, and the second leading cause of death. Sargassum is a genus of brown algae which exhibits its natural therapeutic potential with anticancer properties. This study aimed to identify a therapeutic target for OSCC metastasized from breast cancer through network pharmacology and to evaluate potent phytochemicals against the identified target.

Methods: DEGs associated with OSCC and breast cancer were obtained from the Gene Expression Omnibus. The upregulated DEGs were then intersected to identify common targets between OSCC and BC. …

Butterworth Filter To Reduce Reactivity Fluctuations, Daniel Suescún-Díaz, Geraldyne Ule-Duque, Luis E. Cardoso-Páez

Karbala International Journal of Modern Science

In this study, we introduce the calculation of reactivity in nuclear reactors. The proposed method uses the Euler-Maclaurin series to approximate the integral in the inverse equation of point kinetics. The approximation is done with the first three terms, the first term represents the approximation of a zero-order sum, the second term the trapezoidal rule and the third term the first Bernoulli number. These three terms improve the approximation, along with an estimate of the neutron density using the prompt jump approximation. To reduce neutron density fluctuations, a second-order Butterworth filter for the reactivity calculation was implemented, which offers the …

Integrating Multiscale Geospatial Analysis For Monitoring Crop Growth, Nutrient Distribution, And Hydrological Dynamics In Large-Scale Agricultural Systems, Olatunde D. Akanbi, Deepa C. Bhuvanagiri, Erika I. Barcelos, Arafath Nihar, Brian Gonzalez Hernandez, Jeffrey M. Yarus, Roger H. French

Faculty Scholarship

Monitoring crop growth, soil conditions, and hydrological dynamics are imperative for sustainable agriculture and reduced environmental impacts. This interdisciplinary study integrates remote sensing, digital soil mapping, and hydrological data to elucidate intricate connections between these factors in the state of Ohio, USA. Advanced spatiotemporal analysis techniques were applied to key datasets, including the MODIS sensor satellite imagery, USDA crop data, soil datasets, Aster GDEM, and USGS stream gauge measurements. Vegetation indices derived from MODIS characterized crop-specific phenology and productivity patterns. Exploratory spatial data analysis show relationships of vegetation dynamics and soil properties, uncovering links between plant vigor, edaphic fertility, and …