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Articles 29041 - 29070 of 255945
Full-Text Articles in Life Sciences
Differential Upregulation Of Th1/Th17-Associated Proteins And Pd-L1 In Granulomatous Mycosis Fungoides, Mario L Marques-Piubelli, Jesus Navarrete, Debora A Ledesma, Courtney W Hudgens, Rossana N Lazcano, Auris Huen, Priyadharsini Nagarajan, Phyu P Aung, Ignacio I Wistuba, Jonathan L Curry, Roberto N Miranda, Carlos A Torres-Cabala
Differential Upregulation Of Th1/Th17-Associated Proteins And Pd-L1 In Granulomatous Mycosis Fungoides, Mario L Marques-Piubelli, Jesus Navarrete, Debora A Ledesma, Courtney W Hudgens, Rossana N Lazcano, Auris Huen, Priyadharsini Nagarajan, Phyu P Aung, Ignacio I Wistuba, Jonathan L Curry, Roberto N Miranda, Carlos A Torres-Cabala
Faculty, Staff and Student Publications
Granulomatous Mycosis Fungoides (GMF) is a rare form of mycosis fungoides (MF) characterized by a granulomatous infiltrate associated with the neoplastic lymphoid population and is considered to have a worse prognosis compared with regular MF. The upregulation of the T helper (Th) axis, especially Th17, plays an important role in the pathogenesis of several inflammatory/infectious granulomatous cutaneous diseases, but its role in GMF is still not elucidated to date. In this study, we evaluated the immunohistochemical expression of Th1 (Tbet), Th2 (GATA-3), Th17 (RORγT), T regulatory (Foxp3), and immune checkpoint (IC) (PD-1 and PD-L1) markers in a cohort of patients …
Mortality After Major Cardiovascular Events In Survivors Of Childhood Cancer, Wendy Bottinor, Cindy Im, David R Doody, Saro H Armenian, Alexander Arynchyn, Rebecca M Howell, Kirsten K Ness, Kevin C Oeffinger, Alexander P Reiner, Gregory T Armstrong, Yutaka Yasui, Eric J Chow
Mortality After Major Cardiovascular Events In Survivors Of Childhood Cancer, Wendy Bottinor, Cindy Im, David R Doody, Saro H Armenian, Alexander Arynchyn, Rebecca M Howell, Kirsten K Ness, Kevin C Oeffinger, Alexander P Reiner, Gregory T Armstrong, Yutaka Yasui, Eric J Chow
Faculty, Staff and Student Publications
Background: Adult survivors of childhood cancer are at risk for cardiovascular events.
Objectives: In this study, we sought to determine the risk for mortality after a major cardiovascular event among childhood cancer survivors compared with noncancer populations.
Methods: All-cause and cardiovascular cause-specific mortality risks after heart failure (HF), coronary artery disease (CAD), or stroke were compared among survivors and siblings in the Childhood Cancer Survivor Study (CCSS) and participants in the Coronary Artery Risk Development in Young Adults (CARDIA) study. Cox proportional hazard regression models were used to estimate HRs and 95% CIs between groups, adjusted for demographic and clinical …
Prognostic Risk Signature In Patients With Acute Myeloid Leukemia Treated With Hypomethylating Agents And Venetoclax, Alex Bataller, Alexandre Bazinet, Courtney D Dinardo, Abhishek Maiti, Gautam Borthakur, Nicholas J Short, Ghayas C Issa, Naveen Pemmaraju, Musa Yilmaz, Guillermo Montalban-Bravo, Koichi Takahashi, Sanam Loghavi, Guillermo Garcia-Manero, Farhad Ravandi, Hagop M Kantarjian, Tapan M Kadia
Prognostic Risk Signature In Patients With Acute Myeloid Leukemia Treated With Hypomethylating Agents And Venetoclax, Alex Bataller, Alexandre Bazinet, Courtney D Dinardo, Abhishek Maiti, Gautam Borthakur, Nicholas J Short, Ghayas C Issa, Naveen Pemmaraju, Musa Yilmaz, Guillermo Montalban-Bravo, Koichi Takahashi, Sanam Loghavi, Guillermo Garcia-Manero, Farhad Ravandi, Hagop M Kantarjian, Tapan M Kadia
Faculty, Staff and Student Publications
Hypomethylating agents (HMAs) and venetoclax (Ven) represent the standard of care for patients with acute myeloid leukemia (AML) who are ineligible for intensive chemotherapy. However, the European LeukemiaNet (ELN) risk classifications have been validated for patients treated with intensive therapy. In this study, we validate a recently proposed new molecular prognostic risk signature (mPRS) for patients with AML treated with HMAs and Ven. This classification allocated patients to favorable, intermediate (N/KRAS or FLT3-internal tandem duplication mutations), and lower (TP53 mutations) benefit groups. We retrospectively analyzed 159 patients treated with HMA and Ven. The mPRS classification allocated 74 (47%), 31 (19%), …
A Phase 1/2 Study Of Mini-Hyper-Cvd Plus Venetoclax In Patients With Relapsed/Refractory Acute Lymphoblastic Leukemia, Nicholas J Short, Elias Jabbour, Nitin Jain, Jayastu Senapati, Lewis Nasr, Zhenhua Li, Jun J Yang, Naveen Pemmaraju, Maro Ohanian, William G Wierda, Guillermo Montalban-Bravo, Gautam Borthakur, Lina Han, Lianchun Xiao, Xuelin Huang, Regina Abramova, Min Zhao, Rebecca Garris, Marina Konopleva, Farhad Ravandi, Hagop Kantarjian
A Phase 1/2 Study Of Mini-Hyper-Cvd Plus Venetoclax In Patients With Relapsed/Refractory Acute Lymphoblastic Leukemia, Nicholas J Short, Elias Jabbour, Nitin Jain, Jayastu Senapati, Lewis Nasr, Zhenhua Li, Jun J Yang, Naveen Pemmaraju, Maro Ohanian, William G Wierda, Guillermo Montalban-Bravo, Gautam Borthakur, Lina Han, Lianchun Xiao, Xuelin Huang, Regina Abramova, Min Zhao, Rebecca Garris, Marina Konopleva, Farhad Ravandi, Hagop Kantarjian
Faculty, Staff and Student Publications
Preclinical studies suggest that Bcl-2 inhibition with venetoclax has antileukemic activity in acute lymphoblastic leukemia (ALL) and may synergize with conventional chemotherapy. We designed a phase 1/2 clinical trial to evaluate the safety and efficacy of low-intensity chemotherapy in combination with venetoclax in adults with relapsed or refractory ALL. Patients received the mini-hyper-CVD regimen (dose-attenuated hyperfractionated cyclophosphamide, vincristine, and dexamethasone alternating with methotrexate and cytarabine) in combination with venetoclax (200 mg or 400 mg daily) on days 1 to 14 in cycle 1 and on days 1 to 7 in consolidation cycles. Twenty-two patients were treated. The median number of …
Gamma Delta T Cells In Acute Myeloid Leukemia: Biology And Emerging Therapeutic Strategies, Adishwar Rao, Akriti Agrawal, Gautam Borthakur, Venkata Lokesh Battula, Abhishek Maiti
Gamma Delta T Cells In Acute Myeloid Leukemia: Biology And Emerging Therapeutic Strategies, Adishwar Rao, Akriti Agrawal, Gautam Borthakur, Venkata Lokesh Battula, Abhishek Maiti
Faculty, Staff and Student Publications
γδ T cells play an important role in disease control in acute myeloid leukemia (AML) and have become an emerging area of therapeutic interest. These cells represent a minor population of T lymphocytes with intrinsic abilities to recognize antigens in a major histocompatibility complex-independent manner and functionally straddle the innate and adaptive immunity interface. AML shows high expression of phosphoantigens and UL-16 binding proteins that activate the Vδ2 and Vδ1 subtypes of γδ T cells, respectively, leading to γδ T cell-mediated cytotoxicity. Insights from murine models and clinical data in humans show improved overall survival, leukemia-free survival, reduced risk of …
Bridging Therapy With Axicabtagene Ciloleucel For Large B-Cell Lymphoma: Results From The Us Lymphoma Car-T Consortium, Michael D Jain, Miriam T Jacobs, Feng Gao, Loretta J Nastoupil, Jay Y Spiegel, Saurabh Dahiya, Lazaros Lekakis, Patrick Reagan, Olalekan Oluwole, Joseph Mcguirk, Abhinav Deol, Alison R Sehgal, Andre Goy, Brian T Hill, Charalambos Andreadis, Javier Munoz, Julio C Chavez, N Nora Bennani, Aaron P Rapoport, Julie M Vose, David Miklos, Sattva S Neelapu, Frederick L Locke, Armin Ghobadi
Bridging Therapy With Axicabtagene Ciloleucel For Large B-Cell Lymphoma: Results From The Us Lymphoma Car-T Consortium, Michael D Jain, Miriam T Jacobs, Feng Gao, Loretta J Nastoupil, Jay Y Spiegel, Saurabh Dahiya, Lazaros Lekakis, Patrick Reagan, Olalekan Oluwole, Joseph Mcguirk, Abhinav Deol, Alison R Sehgal, Andre Goy, Brian T Hill, Charalambos Andreadis, Javier Munoz, Julio C Chavez, N Nora Bennani, Aaron P Rapoport, Julie M Vose, David Miklos, Sattva S Neelapu, Frederick L Locke, Armin Ghobadi
Faculty, Staff and Student Publications
During the manufacturing period of autologous chimeric antigen receptor (CAR) T-cell therapy, patients may experience a decline in their condition due to cancer progression. In this study, we investigated the impact of bridging therapy (BT) on the outcome of patients with relapsed/refractory large B-cell lymphoma who received antilymphoma treatment between leukapheresis and axicabtagene ciloleucel (axi-cel) infusion. We conducted our analysis using data from the multicenter US Lymphoma CAR-T Consortium, with a median follow-up of 33 months (range, 4.3-42.1). Out of the 298 patients who underwent leukapheresis, 275 patients received axi-cel. A total 52% of patients (n = 143) who received …
Protein-Folding Chaperones Predict Structure-Function Relationships And Cancer Risk In Brca1 Mutation Carriers, Brant Gracia, Patricia Montes, Angelica Maria Gutierrez, Banu Arun, Georgios Ioannis Karras
Protein-Folding Chaperones Predict Structure-Function Relationships And Cancer Risk In Brca1 Mutation Carriers, Brant Gracia, Patricia Montes, Angelica Maria Gutierrez, Banu Arun, Georgios Ioannis Karras
Faculty, Staff and Student Publications
Predicting the risk of cancer mutations is critical for early detection and prevention, but differences in allelic severity of human carriers confound risk predictions. Here, we elucidate protein folding as a cellular mechanism driving differences in mutation severity of tumor suppressor BRCA1. Using a high-throughput protein-protein interaction assay, we show that protein-folding chaperone binding patterns predict the pathogenicity of variants in the BRCA1 C-terminal (BRCT) domain. HSP70 selectively binds 94% of pathogenic BRCA1-BRCT variants, most of which engage HSP70 more than HSP90. Remarkably, the magnitude of HSP70 binding linearly correlates with loss of folding and function. We identify a prevalent …
Vitamin E Biofortification: Enhancement Of Seed Tocopherol Concentrations By Altered Chlorophyll Metabolism, Ping Qin, Peng Chen, Yuanwei Zhou, Wei Zhang, Yunyun Zhang, Jingjing Xu, Lu Gan, Yingnan Liu, Jill Romer, Peter Dörmann, Edgar B. Cahoon, Chunyu Zhang
Vitamin E Biofortification: Enhancement Of Seed Tocopherol Concentrations By Altered Chlorophyll Metabolism, Ping Qin, Peng Chen, Yuanwei Zhou, Wei Zhang, Yunyun Zhang, Jingjing Xu, Lu Gan, Yingnan Liu, Jill Romer, Peter Dörmann, Edgar B. Cahoon, Chunyu Zhang
Department of Biochemistry: Faculty Publications
Homogentisate Phytyltransferase (HPT) catalyzes condensation of homogentisate (HGA) and phytyl diphosphate (PDP) to produce tocopherols, but can also synthesize tocotrienols using geranylgeranyl diphosphate (GGDP) in plants engineered for deregulated HGA synthesis. In contrast to prior tocotrienol biofortification efforts, engineering enhanced tocopherol concentrations in green oilseeds has proven more challenging due to the integral role of chlorophyll metabolism in supplying the PDP substrate. This study show that RNAi suppression of CHLSYN coupled with HPT overexpression increases tocopherol concentrations by >two-fold in Arabidopsis seeds. We obtained additional increases in seed tocopherol concentrations by engineering increased HGA production via overexpression of …
Isokinetic Versus Isotonic Resistance Training: Defining The Mechanisms Of Hypertrophy And Exercise Execution Methods, George Daughtry
Isokinetic Versus Isotonic Resistance Training: Defining The Mechanisms Of Hypertrophy And Exercise Execution Methods, George Daughtry
Doctorate in Kinesiology
Abstract
Purpose: To determine strength changes and hypertrophy differences at the biceps brachii between an isokinetic bicep curl machine created by C&M Machines and preacher curl exercise with a standard curl bar. The study also aimed to determine the effectiveness of the aforementioned machine and to give insight into this unique method of training.
Methods: A medical clearance form and a Physical Activity Readiness Questionnaire was implemented to evaluate ability to exercise. 10 subjects (n=10) were recruited, were 20.3 years old (20 +/- 2), and were cleared for rigorous exercise. Subjects were randomly assigned to a control group …
Ecology And Management Of The Crapemyrtle Aphid (Hemiptera: Aphididae) On Crapemyrtle (Myrtales: Lythraceae) In The Southern United States, Caleb J. Wilson, Matthew A. Bertone
Ecology And Management Of The Crapemyrtle Aphid (Hemiptera: Aphididae) On Crapemyrtle (Myrtales: Lythraceae) In The Southern United States, Caleb J. Wilson, Matthew A. Bertone
Entomology Faculty Publications
Crapemyrtle aphid [Sarucallis kahawaluokalani (Kirkaldy 1907)] (CMA) is an introduced pest of crapemyrtle (Lagerstroemia spp. L.), which is among the most common ornamental tree genera in the southern United States. Native to Southeast Asia, CMA has become established on 5 other continents. CMAs produce honeydew as they feed which supports sooty mold growth and can result in leaf defoliation on infested trees. CMAs tend to be most abundant in crapemyrtles planted in locations with extensive surrounding impervious surface cover. A large community of generalist natural enemies are found in close association with CMA, which suggests that CMAs may help conserve …
Relation Of Life Sciences Students’ Metacognitive Monitoring To Neural Activity During Biology Error Detection, Mei Grace Behrendt, Caron Clark, Mckenna Elliott, Joseph Dauer
Relation Of Life Sciences Students’ Metacognitive Monitoring To Neural Activity During Biology Error Detection, Mei Grace Behrendt, Caron Clark, Mckenna Elliott, Joseph Dauer
Department of Educational Psychology: Faculty Publications
Metacognitive calibration—the capacity to accurately self-assess one’s performance—forms the basis for error detection and self-monitoring and is a potential catalyst for conceptual change. Limited brain imaging research on authentic learning tasks implicates the lateral prefrontal and anterior cingulate brain regions in expert scientific reasoning. This study aimed to determine how variation in undergraduate life sciences students’ metacognitive calibration relates to their brain activity when evaluating the accuracy of biological models. Fifty undergraduate students enrolled in an introductory life sciences course completed a biology model error detection task during fMRI. Students with higher metacognitive calibration recruited lateral prefrontal regions linked in …
The Spliceosome-Associated Protein Cwc15 Promotes Mirna Biogenesis In Arabidopsis, Bangjun Zhou, Huihui Yu, Yong Xue, Mu Li, Chi Zhang, Bin Yu
The Spliceosome-Associated Protein Cwc15 Promotes Mirna Biogenesis In Arabidopsis, Bangjun Zhou, Huihui Yu, Yong Xue, Mu Li, Chi Zhang, Bin Yu
School of Biological Sciences: Faculty Publications
MicroRNAs (miRNAs) play a key role in regulating gene expression and their biogenesis is precisely controlled through modulating the activity of microprocessor. Here, we report that CWC15, a spliceosome-associated protein, acts as a positive regulator of miRNA biogenesis. CWC15 binds the promoters of genes encoding miRNAs (MIRs), promotes their activity, and increases the occupancy ofDNA-dependent RNA polymerases atMIR promoters, suggesting that CWC15 positively regulates the transcription of primary miRNA transcripts (pri-miRNAs). In addition, CWC15 interacts with Serrate (SE) and HYL1, two key components of microprocessor, and is required for efficient primiRNA processing and the HYL1-pri-miRNA interaction. Moreover, CWC15 interacts with …
Fully Automated Deep Learning Based Auto-Contouring Of Liver Segments And Spleen On Contrast-Enhanced Ct Images, Aashish C Gupta, Guillaume Cazoulat, Mais Al Taie, Sireesha Yedururi, Bastien Rigaud, John Wood, Caleb O'Connor, Usama Salem, Jessica Albuquerque Marques Silva, Aaron Kyle Jones, Molly Mcculloch, Bruno C Odisio, Eugene J Koay, Kristy K Brock
Fully Automated Deep Learning Based Auto-Contouring Of Liver Segments And Spleen On Contrast-Enhanced Ct Images, Aashish C Gupta, Guillaume Cazoulat, Mais Al Taie, Sireesha Yedururi, Bastien Rigaud, John Wood, Caleb O'Connor, Usama Salem, Jessica Albuquerque Marques Silva, Aaron Kyle Jones, Molly Mcculloch, Bruno C Odisio, Eugene J Koay, Kristy K Brock
Faculty, Staff and Student Publications
Manual delineation of liver segments on computed tomography (CT) images for primary/secondary liver cancer (LC) patients is time-intensive and prone to inter/intra-observer variability. Therefore, we developed a deep-learning-based model to auto-contour liver segments and spleen on contrast-enhanced CT (CECT) images. We trained two models using 3d patch-based attention U-Net ([Formula: see text] and 3d full resolution of nnU-Net ([Formula: see text] to determine the best architecture ([Formula: see text]. BA was used with vessels ([Formula: see text] and spleen ([Formula: see text] to assess the impact on segment contouring. Models were trained, validated, and tested on 160 ([Formula: see text]), …
Grit And Second Language Learning Engagement: The Mediating Role Of Affect Balance, Chenggang Wu, Xiaoyong Tian, Hui Jin
Grit And Second Language Learning Engagement: The Mediating Role Of Affect Balance, Chenggang Wu, Xiaoyong Tian, Hui Jin
Faculty, Staff and Student Publications
The study of the relationship between key psychological attributes of learners and their engagement in second language (L2) learning helps to understand the critical personality mechanisms influencing language learning. The present study examined the L2 learning engagement from the perspectives of grit (i.e., consistent efforts and interests devoted to a long-term goal) and affect balance (a notion that takes into account both positive and negative emotions concurrently, assessing and evaluating which side holds more significance or influence). A cohort of English L2 learners (
Clinical Benefit From Docetaxel +/- Ramucirumab Is Not Associated With Mutation Status In Metastatic Non-Small-Cell Lung Cancer Patients Who Progressed On Platinum Doublets And Immunotherapy, Kang Qin, Kaiwen Wang, Shenduo Li, Lingzhi Hong, Priyadharshini Padmakumar, Shawna M Hubert, Natalie Vokes, Kunal Rai, Ara Vaporciyan, Don L Gibbons, John V Heymach, J Jack Lee, Scott E Woodman, Caroline Chung, David A Jaffray, Mehmet Altan, Yanyan Lou, Jianjun Zhang
Clinical Benefit From Docetaxel +/- Ramucirumab Is Not Associated With Mutation Status In Metastatic Non-Small-Cell Lung Cancer Patients Who Progressed On Platinum Doublets And Immunotherapy, Kang Qin, Kaiwen Wang, Shenduo Li, Lingzhi Hong, Priyadharshini Padmakumar, Shawna M Hubert, Natalie Vokes, Kunal Rai, Ara Vaporciyan, Don L Gibbons, John V Heymach, J Jack Lee, Scott E Woodman, Caroline Chung, David A Jaffray, Mehmet Altan, Yanyan Lou, Jianjun Zhang
Faculty, Staff and Student Publications
Docetaxel +/- ramucirumab remains the standard-of-care therapy for patients with metastatic non-small-cell lung cancer (NSCLC) after progression on platinum doublets and immune checkpoint inhibitors (ICIs). The aim of our study was to investigate whether the cancer gene mutation status was associated with clinical benefits from docetaxel +/- ramucirumab. We also investigated whether platinum/taxane-based regimens offered a better clinical benefit in this patient population. A total of 454 patients were analyzed (docetaxel +/- ramucirumab n=381; platinum/taxane-based regimens n=73). Progression-free survival (PFS) and overall survival (OS) were compared among different subpopulations with different cancer gene mutations and between patients who received docetaxel …
The Future Of Targeted Therapy For Leiomyosarcoma, Ryan A Denu, Amanda M Dann, Emily Z Keung, Michael S Nakazawa, Elise F Nassif Haddad
The Future Of Targeted Therapy For Leiomyosarcoma, Ryan A Denu, Amanda M Dann, Emily Z Keung, Michael S Nakazawa, Elise F Nassif Haddad
Faculty, Staff and Student Publications
Leiomyosarcoma (LMS) is an aggressive subtype of soft tissue sarcoma that arises from smooth muscle cells, most commonly in the uterus and retroperitoneum. LMS is a heterogeneous disease with diverse clinical and molecular characteristics that have yet to be fully understood. Molecular profiling has uncovered possible targets amenable to treatment, though this has yet to translate into approved targeted therapies in LMS. This review will explore historic and recent findings from molecular profiling, highlight promising avenues of current investigation, and suggest possible future strategies to move toward the goal of molecularly matched treatment of LMS. We focus on targeting the …
A Flexible Inventory Of Survey Items For Environmental Concepts Generated Via Special Attention To Content Validity And Item Response Theory, John A. Vucetich, Jeremy T. Bruskotter, Benjamin Ghasemi, Claire E. Rapp, Michael Paul Nelson, Kristina M. Slagle
A Flexible Inventory Of Survey Items For Environmental Concepts Generated Via Special Attention To Content Validity And Item Response Theory, John A. Vucetich, Jeremy T. Bruskotter, Benjamin Ghasemi, Claire E. Rapp, Michael Paul Nelson, Kristina M. Slagle
Michigan Tech Publications
We demonstrate how many important measures of belief about the environmental suffer from poor content validity and inadequate conceptual breadth (dimensionality). We used scholarship in environmental science and philosophy to propose a list of 13 environmental concepts that can be held as beliefs. After precisely articulating the concepts, we developed 85 trial survey items that emphasized content validity for each concept. The concepts’ breadth and the items’ content validity were aided by scrutiny from 17 knowledgeable critics. We administered the trial items to 449 residents of the United States and used item response theory to reduce the 85 trial items …
Sex And Gender In Ageing And Longevity: Highlights From An International Course, Giuseppina Candore, Giulia Accardi, Anna Aiello, Giovannella Baggio, Tiziana Bellini, Vittorio Calabrese, Anna Paola Carreca, Ignazio Carreca, Anna Masucci, Monica Cattaneo, Serena Dato, Danilo Di Bona, Luca Fabris, Caterina Gambino, Gabriele Di Lorenzo, Claudio Franceschi, Mattia Emanuela Ligotti, Maria Cristina Manfrinato, Annibale Alessandro Puca, Martina Tamburello, Roberta Vassallo, Calogero Caruso
Sex And Gender In Ageing And Longevity: Highlights From An International Course, Giuseppina Candore, Giulia Accardi, Anna Aiello, Giovannella Baggio, Tiziana Bellini, Vittorio Calabrese, Anna Paola Carreca, Ignazio Carreca, Anna Masucci, Monica Cattaneo, Serena Dato, Danilo Di Bona, Luca Fabris, Caterina Gambino, Gabriele Di Lorenzo, Claudio Franceschi, Mattia Emanuela Ligotti, Maria Cristina Manfrinato, Annibale Alessandro Puca, Martina Tamburello, Roberta Vassallo, Calogero Caruso
Translational Medicine @ UniSa
Gender medicine is a multidisciplinary science and represents an important perspective for pathophysiological and clinical studies in the third millennium. Here, it is provided an overview of the topics discussed in a recent course on the Role of Sex and Gender in Ageing and Longevity. The paper highlights three themes discussed in the course, i.e., the interaction of gender/sex with, i) the pathophysiology of age-related diseases; ii), the role of genetics and epigenetics in ageing and longevity and, iii) the immune responses of older people to pathogens, vaccines, autoantigens, and allergens. Although largely unexplored, sex and gender are modulators …
Descriptions Of The First Zoeas Of Three Grapid Crabs ( Crustacea: Decapoda: Grapsidae) From Hadhramout Coast-Gulf Of Aden, Ahmed Edah Al Haj
Descriptions Of The First Zoeas Of Three Grapid Crabs ( Crustacea: Decapoda: Grapsidae) From Hadhramout Coast-Gulf Of Aden, Ahmed Edah Al Haj
Hadhramout University Journal of Natural & Applied Sciences
This study aimed to describe the first zoeal stage of three species of the grapsid (Metopograpsus thu-khar, Geograpsus crinipes, Grapsus tenuicrastatus) for the first time in the Gulf of Aden from three stations offshore in the coast of Al Shihr. Samples were collected using a 352 µm plankton net for three months. The larval stage was dissected in detail and the appendages were drawn using a Lucida graphic camera. The species G. tenuicrastatus was distinguished from the known Grapsus species in that the antenna contains five setae ranged in the (3 + 2) system, while in the other species ranged …
Characterizing The Causal Role Of Svep1 In Human Disease, Jared S. Elenbaas
Characterizing The Causal Role Of Svep1 In Human Disease, Jared S. Elenbaas
Arts & Sciences Graduate Student Theses and Dissertations
Sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1 (SVEP1) is a poorly understood, putative extracellular matrix protein. Several human traits and diseases are associated with SVEP1, including coronary artery disease, hypertension, type 2 diabetes, glaucoma, dementia, longevity, and platelet reactivity. This dissertation establishes a causal link between SVEP1 and human disease using Mendelian randomization and mouse models. It also provides insights into the disease mechanisms of the protein, including a novel interaction between SVEP1 and the orphan receptor Platelet endothelial aggregation receptor 1. The relevance of this interaction to platelet biology and its potential role in …
Powdery Mildew Of Bigleaf Hydrangea: Biology, Control, And Breeding Strategies For Resistance, Christina Jennings, Fulya Baysal-Gurel, Lisa W. Alexander
Powdery Mildew Of Bigleaf Hydrangea: Biology, Control, And Breeding Strategies For Resistance, Christina Jennings, Fulya Baysal-Gurel, Lisa W. Alexander
Agricultural and Environmental Sciences Faculty Research
Hydrangea macrophylla, commonly known as bigleaf, garden, French, or florist hydrangea, is the most economically important member of the Hydrangea genus, with a breeding history spanning hundreds of years. Bigleaf hydrangea breeding improvement has largely focused on aesthetic traits and there are few varieties tolerant or resistant to major diseases such as powdery mildew. Powdery mildew is an obligate biotrophic Ascomycete in the order Erysiphales represented by approximately 900 species worldwide. The disease-causing agent in hydrangeas is Golovinomyces orontii (formerly Erysiphe polygoni DC), which tarnishes the beauty, growth, and salability of bigleaf hydrangea plants, especially those packed closely in production …
Mechanisms Of Electrical Substrate Reprogramming After Cardiac Radiotherapy, David Meng Zhang
Mechanisms Of Electrical Substrate Reprogramming After Cardiac Radiotherapy, David Meng Zhang
Arts & Sciences Graduate Student Theses and Dissertations
Ventricular tachycardia (VT) is frequently associated with morbidity in patients with heart disease and can lead to sudden cardiac death, which accounts for over 350,000 deaths per year and nearly half of all cardiovascular-related deaths in the United States. Despite its status as a major public health concern, arrhythmia management strategies are severely limited in safety and efficacy. Standards-of-care include defibrillators, anti-arrhythmic drugs, and/or ablations. Implantable cardioverter defibrillators improve survival in at-risk populations but severely reduce quality-of-life and increase risks of further-declining ventricular function. Pharmacologic interventions are limited in efficacy and have dozens of off-target effects which are major sources …
Soil Nitrification Inhibition With Plantain (Plantago Lanceolata), M. E. Peterson, P. M. Fraser, C. R. Anderson, N. I. Joyce, H. G. Judson
Soil Nitrification Inhibition With Plantain (Plantago Lanceolata), M. E. Peterson, P. M. Fraser, C. R. Anderson, N. I. Joyce, H. G. Judson
IGC Proceedings (1977-2023)
One strategy to reduce nitrogen losses from intensively grazed forage systems is to slow the first stage of soil nitrification, specifically inhibiting the microbial oxidation of ammonium to nitrite. Plantain (Plantago lanceolata) leaves and roots are known to contain several bioactive compounds (e.g., aucubin, catalpol and verbascoside) that may contribute to this inhibition. Recent laboratory studies indicate that this inhibition occurs via consumption by grazing animals of precursor bioactive compounds in aboveground biomass and their subsequent excretion as secondary metabolites in urine and/or via active exudation from the roots. Different cultivars of plantain have been shown to impart …
Forage Genomics Accelerate The Germplasm Resource Innovation, Fan Wu, Qi Yan, Pan Xu, Zhen Duan, Jiyu Zhang
Forage Genomics Accelerate The Germplasm Resource Innovation, Fan Wu, Qi Yan, Pan Xu, Zhen Duan, Jiyu Zhang
IGC Proceedings (1977-2023)
To achieve sustainability and food security we need expand the germplasm base and access novel genetic diversity to accelerate breeding. For developing new forage cultivars, the availability of a high-quality genome facilitates accurate characterization of new germplasm, and an understanding of the genetics underlying important traits. Here, we sequenced and assembled three high-quality chromosome-level forage genomes. The contig-level assembly of Cleistogenes songorica (2n = 4x = 40) comprised 540.12 Mb of the genome, with a contig N50 of 21.28 Mb. Complete assemblies of all telomeres, and of ten chromosomes were derived. The chromosome-scale genome size of elephant grass (2n = …
Theory And Application Of No-Till Reseeding Technology In Degraded Grasslands In China, Jingying Jing, Hongyan Ma, Yingjun Zhang
Theory And Application Of No-Till Reseeding Technology In Degraded Grasslands In China, Jingying Jing, Hongyan Ma, Yingjun Zhang
IGC Proceedings (1977-2023)
Grasslands occupy nearly 400 million hectares in China, accounting for about 40.7% of the total land area, provide multiple ecological and economic benefits. However, due to over-grazing and over-cultivation, more than 90% grasslands in China are threatened by degradation that has caused significant negative impact on biodiversity and ecosystem functioning, such as biodiversity losses, decreased productivity, increased soil erosion etc. Thus, restoration of degraded grassland is urgent for sustainable grassland management in China. No-till reseeding has been found to be an effective way for grassland vegetation regeneration with improved productivity and increased plant diversity via reseeding suitable species with minimum …
Rangeland-Centered Agroecosystems In Indian Central Himalayas: Operationalizing Ecological Sustainability In Mountain Agriculture, Vir Singh
IGC Proceedings (1977-2023)
Himalayan Mountains are home to unique agroecosystems harboring unique inter- and intra-species diversity in uncultivated and cultivated lands. The uncultivated lands are largely the rangelands which are ecologically more stable ecosystems than the cultivated lands which are ecologically prone areas. Rangelands, cultivated areas, and livestock in mountain agriculture are in organic linkages with each other, woven into a complex unitary whole, functionally oriented to produce foods and other life-supporting products – such as feed, fiber, fuel, fertilizers, etc. – and provide vital ecological functions. Rangelands in fragile Himalayan mountains serve as a key component of agriculture and the biodiversity conserved …
Mentoring Graduate Students For Academic Careers In Grassland Science, L. E. Sollenberger
Mentoring Graduate Students For Academic Careers In Grassland Science, L. E. Sollenberger
IGC Proceedings (1977-2023)
Effective mentorship enhances student productivity and career achievements, yet faculty generally do not receive mentorship training, nor does mentorship receive focused attention, evaluation, and recognition. The objectives of this paper are to 1) define mentorship and identify roles of a mentor, 2) highlight qualities and outcomes of effective mentoring, and 3) elaborate best mentoring practices, metrics for assessing mentoring, and challenges for mentoring the next generation of grassland scientists. Mentoring is a professional alliance where individuals work together to support the personal and professional growth, development, and success of the relational partners. Mentors should be altruistic discipline experts, have substantial …
National Forage Week, B. Stefancik, K. Mullenix
National Forage Week, B. Stefancik, K. Mullenix
IGC Proceedings (1977-2023)
Social media can be a powerful tool for producers, researchers, and grassland professionals. Social media enables us to connect with a wide audience of producers, Extension personnel, colleagues, industry partners, and even the non-agriculture related community. This presentation in the thematic session on “Understanding the role of social media and digital resources in forage education and promotion” will focus on the impact of National Forage Week. National Forage Week is national campaign initiated by the American Forage and Grassland Council to promote forages and their contributions to society.
Maize-Alfalfa Intercropping Promote Ecosystem Services Than Fertilized Single Crops, D. X. Tao, Y. Z. Gao
Maize-Alfalfa Intercropping Promote Ecosystem Services Than Fertilized Single Crops, D. X. Tao, Y. Z. Gao
IGC Proceedings (1977-2023)
Phosphorus is a non-renewable source of fertilization, which will challenge the future of food production and cropland sustainability worldwide. Crop diversity is known to promote food production, yet its capacity to alleviate the dependence of multiple ecosystem services on non-renewable fertilization remains virtually unknown. Here, we conducted a field experiment to quantify the contribution of maize-alfalfa intercropping to support multiple ecosystem services under contrasting levels of phosphorus fertilization. We showed that unfertilized intercropping systems can support larger levels of multiple ecosystem services such as soil microbial habitat, plant-soil mutualism, nutrient cycling, and soil carbon storage compared with phosphorus-fertilized single crops. …
Identification Of Hyperspectral Characteristics Of The Main Plants In Seriphidium Transiliense Desert Grassland, Wenhao Liu, Wanqiang Han, Guili Jin, Ying Li, Ke Gong, Jian Ma, Zhibiao Liu, Jiazin Li, Mengtian Chen
Identification Of Hyperspectral Characteristics Of The Main Plants In Seriphidium Transiliense Desert Grassland, Wenhao Liu, Wanqiang Han, Guili Jin, Ying Li, Ke Gong, Jian Ma, Zhibiao Liu, Jiazin Li, Mengtian Chen
IGC Proceedings (1977-2023)
Ground hyperspectral images of sericite–Artemisia desert grassland in different seasons were obtained by a soc710 VP imaging spectrometer. Analysis of variance was used to extract the main species Seriphidium transiliense, Ceratocarpus arenarius, and Petrosimonia sibirica and the spectral characteristic parameters and vegetation indices of bare land in different seasons. On this basis, Fisher discriminant analysis was used to divide the samples into a training set and test set according to a ratio of 7:3. The spectral characteristic parameters and vegetation indices were used to identify the three main plants and bare land. Results showed that under Fisher discriminant analysis, …