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Articles 28231 - 28260 of 255960

Full-Text Articles in Life Sciences

Toxicity Of Three Species Of The Solanaceae Family Growing In Algeria Against Culiseta Longiareolata Mosquitos 4th Stage Larvae, Saliha Benhissen, Abdelmaddjid Yagoub Asloum, Nora Belkhiri, Zakaria Hedjouli, Siham Bounadji, Wafa Habbachi, Khellaf Rebbas Mar 2024

Toxicity Of Three Species Of The Solanaceae Family Growing In Algeria Against Culiseta Longiareolata Mosquitos 4th Stage Larvae, Saliha Benhissen, Abdelmaddjid Yagoub Asloum, Nora Belkhiri, Zakaria Hedjouli, Siham Bounadji, Wafa Habbachi, Khellaf Rebbas

Journal of Bioresource Management

Mosquitoes have always been considered a source of harm to humans and animals mainly because they can be vectors of disease. This work represents a study on the effect of aqueous extract of three plants (Hyoscyamus albus, Solanum elaeagnifolium, Solanum nigrum) of the Solanaceae family on the mortality of 4th stage larvae of Culiseta longiareolata larvae. Extract of the high impact is of S. nigrum followed by H. albus and S. elaeagnifolium, respectivley of C. longiareolata larvae.

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Construction Of An Array Of Antibody–Gold Nanoparticle Conjugates For Their Comparative Assessment On Multiplex Lateral Flow Test To Detect Mycotoxins, Bilal Javed Nanolab Research Centre, Vinayak Sharma School Of Food Science And Environmental Health, Furong Tian Nanolab Research Centre Mar 2024

Construction Of An Array Of Antibody–Gold Nanoparticle Conjugates For Their Comparative Assessment On Multiplex Lateral Flow Test To Detect Mycotoxins, Bilal Javed Nanolab Research Centre, Vinayak Sharma School Of Food Science And Environmental Health, Furong Tian Nanolab Research Centre

Articles

Bio-functionalized gold nanoparticles with anti-toxin antibody conjugates have unique physical, biochemical, and optical properties that can greatly improve the performance of biochemical assays because they can enhance the signal intensity of analyte, improve signal transduction, have higher sensitivity of analyte detection, and provide simple colorimetric signal readouts. The surface properties of gold nanoparticles, along with various antibody conjugates, play a significant role in terms of functionalizing gold nanoparticles, and the strategy for surface modification is of great significance to the application of gold nanoparticle-mediated biochemical assays. Spherical gold nanoparticles are among the most used reporter molecules in lateral flow assays. …

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Nebraska Women In Agriculture Conference Marks 39 Years, Ryan Evans, Sarah Treffer, Jessica Groskopf Mar 2024

Nebraska Women In Agriculture Conference Marks 39 Years, Ryan Evans, Sarah Treffer, Jessica Groskopf

Cornhusker Economics

The Nebraska Women in Agriculture program marked 39 years of educating and empowering females in farming, ranching, and agribusiness, with nearly 380 people attending its annual conference on February 22 and 23, 2024 in Kearney, Nebraska, with a pre-conference session held on February 21. Including 25 workshops, 5 keynotes, and activities to help learn about risk management, farm and ranch improvement, and successful business practices.

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The Effects Of Genetic And Modifiable Risk Factors On Brain Regions Vulnerable To Ageing And Disease, Jordi Manuello, Joosung Min, Paul Mccarthy, Fidel Alfaro-Almagro, Soojin Lee, Stephen Smith, Lloyd T. Elliott, Anderson M. Winkler, Gwenaëlle Douaud Mar 2024

The Effects Of Genetic And Modifiable Risk Factors On Brain Regions Vulnerable To Ageing And Disease, Jordi Manuello, Joosung Min, Paul Mccarthy, Fidel Alfaro-Almagro, Soojin Lee, Stephen Smith, Lloyd T. Elliott, Anderson M. Winkler, Gwenaëlle Douaud

School of Medicine Publications

We have previously identified a network of higher-order brain regions particularly vulnerable to the ageing process, schizophrenia and Alzheimer’s disease. However, it remains unknown what the genetic influences on this fragile brain network are, and whether it can be altered by the most common modifiable risk factors for dementia. Here, in ~40,000 UK Biobank participants, we first show significant genome-wide associations between this brain network and seven genetic clusters implicated in cardiovascular deaths, schizophrenia, Alzheimer’s and Parkinson’s disease, and with the two antigens of the XG blood group located in the pseudoautosomal region of the sex chromosomes. We further reveal …

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Design And Processing Test Of Eel Automatic Filleting Machine, Liu Mingyong, Ouyang Zhouhuan, Han Xinguang, Xiang Xue, Zhu Lin Mar 2024

Design And Processing Test Of Eel Automatic Filleting Machine, Liu Mingyong, Ouyang Zhouhuan, Han Xinguang, Xiang Xue, Zhu Lin

Food and Machinery

Objective: A special cutting mechanism for slicing elongated fish with smooth surface was designed. Methods: Taking the slimy eel as the research object, the mechanism of clamping and cutting operation was analyzed. Taking cutting quality and cutting time as test indexes, the influence of main parameters such as clamping wheel speed, cutting tool speed and clamping wheel surface geometry on cutting quality and cutting time were investigated. Results: The main factors affecting cutting quality were blade speed and clamping wheel limit height, and the most important factors affecting cutting time were clamping wheel speed. When the clamping wheel limit height …

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Different Currencies For Calculating Resource Phenology Result In Opposite Inferences About Trophic Mismatches, Tom S. L. Versluijs, Mikhail K. Zhemchuzhnikov, Dmitry Kutcherov, Tomas Roslin, Niels Martin Schmidt, Jan A. Van Gils, Jeroen Reneerkens Mar 2024

Different Currencies For Calculating Resource Phenology Result In Opposite Inferences About Trophic Mismatches, Tom S. L. Versluijs, Mikhail K. Zhemchuzhnikov, Dmitry Kutcherov, Tomas Roslin, Niels Martin Schmidt, Jan A. Van Gils, Jeroen Reneerkens

Biological Sciences Faculty Publications and Presentations

Shifts in phenology are among the key responses of organisms to climate change. When rates of phenological change differ between interacting species they may result in phenological asynchrony. Studies have found conflicting patterns concerning the direction and magnitude of changes in synchrony, which have been attributed to biological factors. A hitherto overlooked additional explanation are differences in the currency used to quantify resource phenology, such as abundance and biomass. Studying an insectivorous bird (the sanderling) and its prey, we show that the median date of cumulative arthropod biomass occurred, on average, 6.9 days after the median date of cumulative arthropod …

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Prescribed Fire Effects On Microbial Communities And Functions In Managed Ecosystems, Viet Dao Mar 2024

Prescribed Fire Effects On Microbial Communities And Functions In Managed Ecosystems, Viet Dao

LSU Doctoral Dissertations

Microbes (both fungi and bacteria) serve important ecosystem functional roles in nutrient cycling and decomposition, which affect ecosystem response following disturbances such as prescribed fire. A multitude of abiotic and biotic factors influence microbial community compositions, which then drive microbial ecosystem functions. The factors driving microbial communities further change due to fire disturbances and progression with time. Although prescribed fire is commonly used as a technique for ecosystem management, the effects of fire on microbial communities or their functions are simply understudied. Ecosystem management decisions tend to focus on plant and ecosystem post-fire responses. Thus, incorporation of fire effects on …

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High-Density Glass Scintillators For Proton Radiography-Relative Luminosity, Proton Response, And Spatial Resolution, Ethan Stolen, Ryan Fullarton, Rain Hein, Robin L Conner, Luiz G Jacobsohn, Sam Beddar, Daniel Robertson Mar 2024

High-Density Glass Scintillators For Proton Radiography-Relative Luminosity, Proton Response, And Spatial Resolution, Ethan Stolen, Ryan Fullarton, Rain Hein, Robin L Conner, Luiz G Jacobsohn, Sam Beddar, Daniel Robertson

Faculty, Staff and Student Publications

Proton radiography is a promising development in proton therapy, and researchers are currently exploring optimal detector materials to construct proton radiography detector arrays. High-density glass scintillators may improve integrating-mode proton radiography detectors by increasing spatial resolution and decreasing detector thickness. We evaluated several new scintillators, activated with europium or terbium, with proton response measurements and Monte Carlo simulations, characterizing relative luminosity, ionization quenching, and proton radiograph spatial resolution. We applied a correction based on Birks's analytical model for ionization quenching. The data demonstrate increased relative luminosity with increased activation element concentration, and higher relative luminosity for samples activated with europium. …

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Near-Neutral Balanced Selection Theory (Nnbst): Implication On The Molecular Evolution Of Sars-Cov-2 And Zika Virus, Nicholas J. Paradis Mar 2024

Near-Neutral Balanced Selection Theory (Nnbst): Implication On The Molecular Evolution Of Sars-Cov-2 And Zika Virus, Nicholas J. Paradis

Graduate Student and Postdoctoral Fellow Symposium

Virus pandemics have significantly impacted human welfare and development. Understanding the true molecular evolution of viruses is critical for preventing future pandemics and developing the next-generation drugs and vaccines. Unfortunately, viruses exhibiting constant genomic substitution rates (GSRs) despite increasing vaccinations and human infections (SARS-CoV-2) and viruses under seemingly extreme conservation (ZIKV) paints a confusing picture of viral evolution, and the main evolutionary theories (Selectionist Theory, Kimura’s Neutral Theory) cannot explain their molecular evolution. Here, we developed a first-principle model, c/u, to characterize reproductive fitness changes in viruses based on variations in the nucleotide/codon mutation rate (c) with respect to the …

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Vigilance And Foraging Behaviors Of Two Sciurid Species Between College Campuses And Urban Environments, Patrick Geyer, Zoe Buffington, Lorelei E. Patrick Mar 2024

Vigilance And Foraging Behaviors Of Two Sciurid Species Between College Campuses And Urban Environments, Patrick Geyer, Zoe Buffington, Lorelei E. Patrick

SACAD: Scholarly Activities

A comparison between the extent that sciurid specimens display vigilance and foraging behaviors on college campuses against specimens within urban environments. Observations of fox squirrels and western gray squirrels were taken from the Squirrel-Net behavioral database used for this project. We found there was a significant difference between the percent vigilance behaviors and foraging behaviors on college campuses compared to urban environments. This suggests that squirrels residing on college campuses are more desensitized to pedestrian activity and foot traffic compared to squirrels that inhabit urban areas.

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Generating Crispr Mutations In The Asymmetric Leaves1 Gene Of Arabidopsis, Gabriella J. Rueschhoff, Tara Phelps-Durr Mar 2024

Generating Crispr Mutations In The Asymmetric Leaves1 Gene Of Arabidopsis, Gabriella J. Rueschhoff, Tara Phelps-Durr

SACAD: Scholarly Activities

The goal of this study is to create new mutations in the ASYMMETRIC LEAVES 1 (AS1) gene of Arabidopsis using CRISPR technology. AS1 is a myb domain transcription factor that represses the KNOX genes, a group of genes involved in maintaining an undifferentiated cell state. AS1 binds to the chromatin remodeling protein Histone Repressor A (HIRA). In animals, HIRA is involved in the permanent suppression of proliferation genes required for early development. The interaction between AS1 and HIRA provides clues to how AS1 maintains suppression at the KNOX genes; however, we must be careful applying what …

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Biological Significances Of Environmental Pollution In The New Calabar River, Southern Nigeria: A Case Study In Zooplankton Composition, Ibienebo Davies Imachrist, Francis David Sikoki, Philomina Kika, Davies Ibienebo Chris Mar 2024

Biological Significances Of Environmental Pollution In The New Calabar River, Southern Nigeria: A Case Study In Zooplankton Composition, Ibienebo Davies Imachrist, Francis David Sikoki, Philomina Kika, Davies Ibienebo Chris

Journal of Bioresource Management

The study was conducted for three months (May to July 2020), focusing on the physicochemical parameters and zooplankton composition in the Ogbogoro region of the New Calabar River in Nigeria. This investigation was carried out at three distinct monitoring stations. The physicochemical parameters were determined using standard ecological analytic procedures. PAST and SPSS were used for the statistical analysis. The temperature ranged between 26.5 to 33 ºC, salinity (1.23 to 1.86 %), pH (7.4 to 9.62), Total Dissolved Solids (2419 to 5,817 mg/L), conductivity (223.83 to 7,328 μS/cm), turbidity (3.415 to 15.05 NTU) and Dissolved Oxygen (3.8 to 6.8 mg/L). …

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Impact Of Infestation Of Flour By Stored Food Pest Insects Ephestia Kuehniella On Quality Flour: Physico-Chemical Analyses, Hadjira Bendjedid, Samira Yezli-Touiker, Asma Taffar, Amina Yezli, Nabila Souileh Mar 2024

Impact Of Infestation Of Flour By Stored Food Pest Insects Ephestia Kuehniella On Quality Flour: Physico-Chemical Analyses, Hadjira Bendjedid, Samira Yezli-Touiker, Asma Taffar, Amina Yezli, Nabila Souileh

Journal of Bioresource Management

The primary reason for significant post-harvest losses globally stems from the infestation of insect pests. These beetles, as they progress through their life cycle, lead to the deterioration of stored food, capable of decimating an entire inventory within a remarkably brief timeframe. Quality control is a system that monitors product quality, assuring and detecting any spoilage of a product, the impact of infestation of flour by pairs of stored food pest insects E. kuehniella on quality flour was evaluated by physicochemical analyses over time. Provoked exposure of 200 g of flour to 5, 10, and 20 couples of Ephestia keuhniella …

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Usage Of Almond And Thyme Oils For The Enhancement Of Shelf Life Of Different Fish Species, Aneeza Kanwal, Roheela Yasmeen, Saima Nazir, Shumaila Usman, Bushra Nisar Khan Mar 2024

Usage Of Almond And Thyme Oils For The Enhancement Of Shelf Life Of Different Fish Species, Aneeza Kanwal, Roheela Yasmeen, Saima Nazir, Shumaila Usman, Bushra Nisar Khan

Journal of Bioresource Management

Fish is an important source of protein for millions of people around the globe and it's often a healthier option compared to some other meats. However, the fish industry is facing a storage challenge in the form of rapid spoilage and deterioration of freshness due to bacterial growth and enzymatic activity. The usage of oils in fish can enhance shelf life by creating a protective barrier. This research was designed to see the effects of thyme and almond oil on nutritional profile and shelf life of fish. The three fish species rohu (Labeo rohita), Mali (Wallago attu) …

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Pre And Post Breeding Morphometric Profile Of European Rabbit (Oryctolagus Cuniculus), Rao Zahid Sattar, Rana Manzoor Ahmad, Abdul Majid Khan, Muhammad Altaf, Muhammad Rizwan, Sajjad Yaseen Mar 2024

Pre And Post Breeding Morphometric Profile Of European Rabbit (Oryctolagus Cuniculus), Rao Zahid Sattar, Rana Manzoor Ahmad, Abdul Majid Khan, Muhammad Altaf, Muhammad Rizwan, Sajjad Yaseen

Journal of Bioresource Management

After 1950s, a continuous decline in the population of Oryctolagus cuniculus has urged the IUCN to declare it an endangered species. There is a serious need to take conservational steps for Oryctolagus cuniculus breeds by research work on their different morphological and physiological aspects. The current study evaluates the growth of European rabbit through morphometric profile at pre breeding, post 1st breeding and post 2nd breeding stages in order to find out the growth trends of the European rabbits at different breeding stages. The studied sample comprised of 42 pairs for each breed (New Zealand White and American …

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Suggested Vegetable Planting Dates: Grand And San Juan Counties, Reagan Wytsalucy, Cory Farnsworth, Dan Drost Mar 2024

Suggested Vegetable Planting Dates: Grand And San Juan Counties, Reagan Wytsalucy, Cory Farnsworth, Dan Drost

All Current Publications

This fact sheet addresses vegetable planting dates in Grand and San Juan counties in Utah. “When should I plant?” and “What should I plant?” are two of the more common questions received from Utah gardeners. To answer the “When” question, you need to know something about the climate where you live. Vegetable plants vary in their response to temperature and are grouped by how they cope with cold or hot conditions. There are four (4) vegetable groups, which include the hardy, half-hardy, tender, or very tender crops. These groups are also referred to as the cool season (hardy or half-hardy) …

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Methionyl-Trna Synthetase Synthetic And Proofreading Activities Are Determinants Of Antibiotic Persistence, Whitney N. Wood, Miguel Angel Rubio, Lorenzo Eugenio Leiva, Gregory J. Phillips, Michael Ibba Mar 2024

Methionyl-Trna Synthetase Synthetic And Proofreading Activities Are Determinants Of Antibiotic Persistence, Whitney N. Wood, Miguel Angel Rubio, Lorenzo Eugenio Leiva, Gregory J. Phillips, Michael Ibba

Biology, Chemistry, and Environmental Sciences Faculty Articles and Research

Bacterial antibiotic persistence is a phenomenon where bacteria are exposed to an antibiotic and the majority of the population dies while a small subset enters a low metabolic, persistent, state and are able to survive. Once the antibiotic is removed the persistent population can resuscitate and continue growing. Several different molecular mechanisms and pathways have been implicated in this phenomenon. A common mechanism that may underly bacterial antibiotic persistence is perturbations in protein synthesis. To investigate this mechanism, we characterized four distinct metG mutants for their ability to increase antibiotic persistence. Two metG mutants encode changes near the catalytic site …

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Biomarkers For Managing Neurodegenerative Diseases, Lara Cheslow, Adam E. Snook, Scott A. Waldman Mar 2024

Biomarkers For Managing Neurodegenerative Diseases, Lara Cheslow, Adam E. Snook, Scott A. Waldman

Department of Pharmacology, Physiology, and Cancer Biology Faculty Papers

Neurological disorders are the leading cause of cognitive and physical disability worldwide, affecting 15% of the global population. Due to the demographics of aging, the prevalence of neurological disorders, including neurodegenerative diseases, will double over the next two decades. Unfortunately, while available therapies provide symptomatic relief for cognitive and motor impairment, there is an urgent unmet need to develop disease-modifying therapies that slow the rate of pathological progression. In that context, biomarkers could identify at-risk and prodromal patients, monitor disease progression, track responses to therapy, and parse the causality of molecular events to identify novel targets for further clinical investigation. …

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Author Correction: Cytoskeleton Remodeling Induced By Smyd2 Methyltransferase Drives Breast Cancer Metastasis, Alexandre G Casanova, Gael S Roth, Simone Hausmann, Xiaoyin Lu, Ludivine J M Bischoff, Lucid Belmudes, Natasha M Flores, Ana Morales Benitez, Tourkian Chasan, Marcello Caporicci, Jessica Vayr, Sandrine Blanchet, Francesco Ielasi, Sophie Rousseaux, Pierre Hainaut, Or Gozani, Muriel Le Romancer, Yohann Couté, Andres Palencia, Pawel K Mazur, Nicolas Reynoird Mar 2024

Author Correction: Cytoskeleton Remodeling Induced By Smyd2 Methyltransferase Drives Breast Cancer Metastasis, Alexandre G Casanova, Gael S Roth, Simone Hausmann, Xiaoyin Lu, Ludivine J M Bischoff, Lucid Belmudes, Natasha M Flores, Ana Morales Benitez, Tourkian Chasan, Marcello Caporicci, Jessica Vayr, Sandrine Blanchet, Francesco Ielasi, Sophie Rousseaux, Pierre Hainaut, Or Gozani, Muriel Le Romancer, Yohann Couté, Andres Palencia, Pawel K Mazur, Nicolas Reynoird

Faculty, Staff and Student Publications

No abstract provided.

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Integration Of Kupffer Cells Into Human Ipsc-Derived Liver Organoids For Modeling Liver Dysfunction In Sepsis, Yang Li, Yunzhong Nie, Xia Yang, Yang Liu, Xiaoshan Deng, Riana Plummer, Na Luo, Toshiharu Kasai, Takashi Okumura, Yu Kamishibahara, Takemasa Komoto, Takuya Ohkuma, Satoshi Okamoto, Yumiko Isobe, Kiyoshi Yamaguchi, Yoichi Furukawa, Hideki Taniguchi Mar 2024

Integration Of Kupffer Cells Into Human Ipsc-Derived Liver Organoids For Modeling Liver Dysfunction In Sepsis, Yang Li, Yunzhong Nie, Xia Yang, Yang Liu, Xiaoshan Deng, Riana Plummer, Na Luo, Toshiharu Kasai, Takashi Okumura, Yu Kamishibahara, Takemasa Komoto, Takuya Ohkuma, Satoshi Okamoto, Yumiko Isobe, Kiyoshi Yamaguchi, Yoichi Furukawa, Hideki Taniguchi

Faculty, Staff and Student Publications

Maximizing the potential of human liver organoids (LOs) for modeling human septic liver requires the integration of innate immune cells, particularly resident macrophage Kupffer cells. In this study, we present a strategy to generate LOs containing Kupffer cells (KuLOs) by recapitulating fetal liver hematopoiesis using human induced pluripotent stem cell (hiPSC)-derived erythro-myeloid progenitors (EMPs), the origin of tissue-resident macrophages, and hiPSC-derived LOs. Remarkably, LOs actively promote EMP hematopoiesis toward myeloid and erythroid lineages. Moreover, supplementing with macrophage colony-stimulating factor (M-CSF) proves crucial in sustaining the hematopoietic population during the establishment of KuLOs. Exposing KuLOs to sepsis-like endotoxins leads to significant …

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Raf Inhibitor Re-Challenge Therapy In Braf-Aberrant Pan-Cancers: The Re-Raffle Study, Blessie Elizabeth Nelson, Jason Roszik, Jibran Ahmed, Carmelia Maria Noia Barretto, Mirella Nardo, Amber M Johnson, Isabella C Glitza Oliva, Shiao-Pei Weathers, Maria Cabanillas, Milind Javle, Funda Meric-Bernstam, Vivek Subbiah Mar 2024

Raf Inhibitor Re-Challenge Therapy In Braf-Aberrant Pan-Cancers: The Re-Raffle Study, Blessie Elizabeth Nelson, Jason Roszik, Jibran Ahmed, Carmelia Maria Noia Barretto, Mirella Nardo, Amber M Johnson, Isabella C Glitza Oliva, Shiao-Pei Weathers, Maria Cabanillas, Milind Javle, Funda Meric-Bernstam, Vivek Subbiah

Faculty, Staff and Student Publications

Previous studies have shown the clinical benefit of rechallenging the RAF pathway in melanoma patients previously treated with BRAF inhibitors. 44 patients with multiple tumors harboring RAF alterations were rechallenged with a second RAF inhibitor, either as monotherapy or in combination with other therapies, after prior therapy with a first RAF inhibitor. This retrospective observational study results showed that rechallenging with RAFi(s) led to an overall response rate of 18.1% [PR in thyroid (1 anaplastic; 3 papillary), 1 ovarian, 2 melanoma, 1 cholangiocarcinoma, and 1 anaplastic astrocytoma]. The clinical benefit rate was 54.5%; more than 30% of patients had durable …

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Correction: The Novel Phosphatase Nudt5 Is A Critical Regulator Of Triple-Negative Breast Cancer Growth, Jing Qian, Yanxia Ma, William M Tahaney, Cassandra L Moyer, Amanda Lanier, Darian Coleman, Susan G Hilsenbeck, Michelle I Savage, Brent D G Page, Abhijit Mazumdar, Powel H Brown Mar 2024

Correction: The Novel Phosphatase Nudt5 Is A Critical Regulator Of Triple-Negative Breast Cancer Growth, Jing Qian, Yanxia Ma, William M Tahaney, Cassandra L Moyer, Amanda Lanier, Darian Coleman, Susan G Hilsenbeck, Michelle I Savage, Brent D G Page, Abhijit Mazumdar, Powel H Brown

Faculty, Staff and Student Publications

No abstract provided.

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A Novel Machine Learning Algorithm Selects Proteome Signature To Specifically Identify Cancer Exosomes, Bingrui Li, Fernanda G Kugeratski, Raghu Kalluri Mar 2024

A Novel Machine Learning Algorithm Selects Proteome Signature To Specifically Identify Cancer Exosomes, Bingrui Li, Fernanda G Kugeratski, Raghu Kalluri

Faculty, Staff and Student Publications

Non-invasive early cancer diagnosis remains challenging due to the low sensitivity and specificity of current diagnostic approaches. Exosomes are membrane-bound nanovesicles secreted by all cells that contain DNA, RNA, and proteins that are representative of the parent cells. This property, along with the abundance of exosomes in biological fluids makes them compelling candidates as biomarkers. However, a rapid and flexible exosome-based diagnostic method to distinguish human cancers across cancer types in diverse biological fluids is yet to be defined. Here, we describe a novel machine learning-based computational method to distinguish cancers using a panel of proteins associated with exosomes. Employing …

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The Genomic And Evolutionary Landscapes Of Anaplastic Thyroid Carcinoma, Peter Y F Zeng, Stephenie D Prokopec, Stephen Y Lai, Nicole Pinto, Michelle A Chan-Seng-Yue, Michelle D Williams, Paul Plantinga, Matthew J Cecchini, Alfred K Lam, Iram Siddiqui, Jianxin Wang, Ren X Sun, John D Watson, Reju Korah, Tobias Carling, Nishant Agrawal, Nicole Cipriani, Douglas Ball, Barry Nelkin, Lisa M Rooper, Justin A Bishop, Cathie Garnis, Ken Berean, Norman G Nicolson, Paul Weinberger, Ying C Henderson, Christopher M Lalansingh, Mao Tian, Takafumi N Yamaguchi, Julie Livingstone, Adriana Salcedo, Krupal Patel, Frederick Vizeacoumar, Alessandro Datti, Liu Xi, Yuri E Nikiforov, Robert Smallridge, John A Copland, Laura A Marlow, Martin D Hyrcza, Leigh Delbridge, Stan Sidhu, Mark Sywak, Bruce Robinson, Kevin Fung, Farhad Ghasemi, Keith Kwan, S Danielle Macneil, Adrian Mendez, David A Palma, Mohammed I Khan, Mushfiq Shaikh, Kara M Ruicci, Bret Wehrli, Eric Winquist, John Yoo, Joe S Mymryk, James W Rocco, David Wheeler, Steve Scherer, Thomas J Giordano, John W Barrett, William C Faquin, Anthony J Gill, Gary Clayman, Paul C Boutros, Anthony C Nichols Mar 2024

The Genomic And Evolutionary Landscapes Of Anaplastic Thyroid Carcinoma, Peter Y F Zeng, Stephenie D Prokopec, Stephen Y Lai, Nicole Pinto, Michelle A Chan-Seng-Yue, Michelle D Williams, Paul Plantinga, Matthew J Cecchini, Alfred K Lam, Iram Siddiqui, Jianxin Wang, Ren X Sun, John D Watson, Reju Korah, Tobias Carling, Nishant Agrawal, Nicole Cipriani, Douglas Ball, Barry Nelkin, Lisa M Rooper, Justin A Bishop, Cathie Garnis, Ken Berean, Norman G Nicolson, Paul Weinberger, Ying C Henderson, Christopher M Lalansingh, Mao Tian, Takafumi N Yamaguchi, Julie Livingstone, Adriana Salcedo, Krupal Patel, Frederick Vizeacoumar, Alessandro Datti, Liu Xi, Yuri E Nikiforov, Robert Smallridge, John A Copland, Laura A Marlow, Martin D Hyrcza, Leigh Delbridge, Stan Sidhu, Mark Sywak, Bruce Robinson, Kevin Fung, Farhad Ghasemi, Keith Kwan, S Danielle Macneil, Adrian Mendez, David A Palma, Mohammed I Khan, Mushfiq Shaikh, Kara M Ruicci, Bret Wehrli, Eric Winquist, John Yoo, Joe S Mymryk, James W Rocco, David Wheeler, Steve Scherer, Thomas J Giordano, John W Barrett, William C Faquin, Anthony J Gill, Gary Clayman, Paul C Boutros, Anthony C Nichols

Faculty, Staff and Student Publications

Anaplastic thyroid carcinoma is arguably the most lethal human malignancy. It often co-occurs with differentiated thyroid cancers, yet the molecular origins of its aggressivity are unknown. We sequenced tumor DNA from 329 regions of thyroid cancer, including 213 from patients with primary anaplastic thyroid carcinomas. We also whole genome sequenced 9 patients using multi-region sequencing of both differentiated and anaplastic thyroid cancer components. Using these data, we demonstrate thatanaplastic thyroid carcinomas have a higher burden of mutations than other thyroid cancers, with distinct mutational signatures and molecular subtypes. Further, different cancer driver genes are mutated in anaplastic and differentiated thyroid …

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A Review On Role Of Bacillus Species In Bio-Calcification: A Way Forward In Carbonate Precipitation, Ardil Bin Mansoor, Sheema Yousaf, Amna Gulzar, Ramsha Iqbal, Aisha Waheed Qurashi Mar 2024

A Review On Role Of Bacillus Species In Bio-Calcification: A Way Forward In Carbonate Precipitation, Ardil Bin Mansoor, Sheema Yousaf, Amna Gulzar, Ramsha Iqbal, Aisha Waheed Qurashi

Journal of Bioresource Management

Bio-calcification, also known as microbiologically induced calcite precipitation, is a phenomenon involving the activity of the enzyme urease. A large number of soil microorganism exhibit urease-producing ability. The main purpose of this review article is to signify the calcium carbonate bio-precipitation by Bacillus species including Lysinibacillus sphaericus and Bacillus subtilis. They both precipitated calcite and the shape and size depending on the external and internal conditions like the type of culture medium and the bacterial strains that were used. The research group increased attentions toward MICP (microbial-induced carbonated precipitation) because of its eco-friendly application. Different bacterial strains had been …

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Genomes Of Multicellular Algal Sisters To Land Plants Illuminate Signaling Network Evolution, Xuehuan Feng, Jinfang Zheng, Iker Irisarri, Huihui Yu, Bo Zheng, Zahin Ali, Sophie De Vries, Jean Keller, Janine M. R. Fürst-Jansen, Armin Dadras, Jaccoline M. S. Zegers, Tim P. Rieseberg, Amra Dhabalia Ashok, Tatyana Darienko, Maaike J. Bierenbroodspot, Lydia Gramzow, Romy Petroll, Fabian B. Haas, Noe Fernandez-Pozo, Orestis Nousias, Tang Li, Elisabeth Fitzek, W. Scott Grayburn, Nina Rittmeier, Charlotte Permann, Florian Rümpler, John M. Archibald, Günter Theißen, Jeffrey P. Mower, Maike Lorenz16, Henrik Buschmann, Klaus Von Schwartzenberg, Lori Boston, Richard D. Hayes, Chris Daum, Kerrie Barry, Igor V. Grigoriev, Xiyin Wang, Fay-Wei Li, Stefan A. Rensing, Julius Ben Ari, Noa Keren, Assaf Mosquna, Andreas Holzinger, Pierre-Marc Delaux, Chi Zhang, Jinling Huang, Marek Mutwil6,, Jan De Vries, Yanbin Yin Mar 2024

Genomes Of Multicellular Algal Sisters To Land Plants Illuminate Signaling Network Evolution, Xuehuan Feng, Jinfang Zheng, Iker Irisarri, Huihui Yu, Bo Zheng, Zahin Ali, Sophie De Vries, Jean Keller, Janine M. R. Fürst-Jansen, Armin Dadras, Jaccoline M. S. Zegers, Tim P. Rieseberg, Amra Dhabalia Ashok, Tatyana Darienko, Maaike J. Bierenbroodspot, Lydia Gramzow, Romy Petroll, Fabian B. Haas, Noe Fernandez-Pozo, Orestis Nousias, Tang Li, Elisabeth Fitzek, W. Scott Grayburn, Nina Rittmeier, Charlotte Permann, Florian Rümpler, John M. Archibald, Günter Theißen, Jeffrey P. Mower, Maike Lorenz16, Henrik Buschmann, Klaus Von Schwartzenberg, Lori Boston, Richard D. Hayes, Chris Daum, Kerrie Barry, Igor V. Grigoriev, Xiyin Wang, Fay-Wei Li, Stefan A. Rensing, Julius Ben Ari, Noa Keren, Assaf Mosquna, Andreas Holzinger, Pierre-Marc Delaux, Chi Zhang, Jinling Huang, Marek Mutwil6,, Jan De Vries, Yanbin Yin

Center for Plant Science Innovation: Faculty Publications

Zygnematophyceae are the algal sisters of land plants. Here we sequenced four genomes of filamentous Zygnematophyceae, including chromosome-scale assemblies for three strains of Zygnema circumcarinatum. We inferred traits in the ancestor of Zygnematophyceae and land plants that might have ushered in the conquest of land by plants: expanded genes for signaling cascades, environmental response, and multicellular growth. Zygnematophyceae and land plants share all the major enzymes for cell wall synthesis and remodifications, and gene gains shaped this toolkit. Co-expression network analyses uncover gene cohorts that unite environmental signaling with multicellular developmental programs. Our data shed light on a molecular …

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Genetic Impact Of External Targhee Sires At The U.S. Sheep Experiment Station: A Case Study Of Introgression, Carrie S. Wilson, J. Bret Taylor, Ronald M. Lewis, David R. Notter Mar 2024

Genetic Impact Of External Targhee Sires At The U.S. Sheep Experiment Station: A Case Study Of Introgression, Carrie S. Wilson, J. Bret Taylor, Ronald M. Lewis, David R. Notter

Department of Animal Science: Faculty Publications

Sheep breeders requested that the U.S. Sheep Experiment Station (USSES) to participate in national genetic evaluation through the National Sheep Improvement Program (NSIP). The reasons included the need for (1) a comparison of the productivity of industry and United States Department of Agriculture (USDA) lines, (2) transparency of USDA flocks, (3) genetic ties for NSIP by sampling of industry flocks, and (4) development of premium genetic lines for public release. In response, USSES began to incorporate external sires from NSIP participating flocks into the USSES Targhee flock. Our objective, based on a pedigree analysis, was to test if introgression of …

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Evaluating Drowning Prevention Campaigns - The Challenge Of Getting The Right Information To The Right People At The Right Time: A Response To Calverley, Petrass, And Blitvich, Gemma Crawford, Meg Abercromby, Malena Della Bona, Justine E. Leavy Ph.D. Mar 2024

Evaluating Drowning Prevention Campaigns - The Challenge Of Getting The Right Information To The Right People At The Right Time: A Response To Calverley, Petrass, And Blitvich, Gemma Crawford, Meg Abercromby, Malena Della Bona, Justine E. Leavy Ph.D.

International Journal of Aquatic Research and Education

Evidence-informed decision making requires timely and readily available research and evaluation for policy and practice. In the context of drowning prevention, evaluation of interventions in the grey and peer reviewed literature is relatively scarce. Lack of evidence and associated barriers to access limits the scope of knowledge translation efforts and the application of research outcomes to initiatives designed to prevent drowning. The paper, Alcohol Focused Drowning Prevention Campaigns: What Do We Know and What Should We Do Now? highlights a lack of specific evaluation for alcohol-focused drowning prevention campaigns. We offer insights as evaluators of a youth water safety program …

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03.25.2024 Orsp Connect, Liz Williamson Mar 2024

03.25.2024 Orsp Connect, Liz Williamson

ORED Newsletter

Cammi Thornton, Compliance Training Requirements

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Altered Lipid Metabolism In Apc-Driven Colorectal Cancer: The Potential For Therapeutic Intervention, Courtney O. Kelson, Yekaterina Y. Zaytseva Mar 2024

Altered Lipid Metabolism In Apc-Driven Colorectal Cancer: The Potential For Therapeutic Intervention, Courtney O. Kelson, Yekaterina Y. Zaytseva

Markey Cancer Center Faculty Publications

Altered lipid metabolism is a well-recognized feature of solid cancers, including colorectal cancer. In colorectal cancer, upregulation of lipid metabolism contributes to initiation, progression, and metastasis; thus, aberrant lipid metabolism contributes to a poor patient outcome. The inactivating mutation of APC, a vital tumor suppressor in the Wnt signaling pathway, is a key event that occurs early in the majority of colorectal cancer cases. The potential crosstalk between lipid metabolism and APC-driven colorectal cancer is poorly understood. This review collectively highlights and summarizes the limited understanding between mutations in APC and the upregulation of Wnt/beta- catenin signaling and lipid metabolism. …

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