Life Sciences Commons^™

Effect Of Lunar Magnetic Field And Lunar Regolith Simulant On The Growth And Bioactive Compounds Production Of Chlorella Vulgaris Microalgae, Jeries Philip Butros Abedrabbo

Mechanical & Aerospace Engineering Theses & Dissertations

Since humans last went to the moon on the Apollo missions, there has been a fascination with inhabiting and colonizing other planetary objects, starting with the Earth’s Moon, Mars, and recently Jupiter’s moon, Europa. However, there is still lack of knowledge and science behind many of the extraterrestrial environmental effects on biological organisms living on Earth. Therefore, there is a need to study how such environments would affect these organisms. Moreover, how can we attain sustainable living in such environments as well through self-providing life support systems (LSS), without the need to provide for additional necessities back and forth from …

Brainlife.Io: A Decentralized And Open-Source Cloud Platform To Support Neuroscience Research, Soichi Hayashi, Bradley A. Caron, Anibal Solon Heinsfeld, Sophia Vinci-Booher, Brent Mcpherson, Daniel N. Bullock, Giulia Berto, Guiomar Niso, Sandra Hanekamp, Daniel Levitas, Kimberly Ray, Anne Mackenzie, Paolo Avesani, Lindsey Kitchell, Josiah K. Leong, Filipi Nascimento-Silva, Serge Koudoro, Hanna Willis, Jasleen K. Jolly, Derek Pisner, Taylor R. Zuidema, Jan W. Kurzawski, Kyriaki Mikellidou, Aurore Bussalb, Maximilien Chaumon, Nathalie George, Christopher Rorden, Conner Victory, Dheeraj Bhatia, Dogu Baran Aydogan, Fang-Chen F. Yeh, Franco Delogu, Javier Guaje, Jelle Veraart, Jeremy Fischer, Joshua Faskowitz, Ricardo Fabrega, David Hunt, Shawn Mckee, Shawn T. Brown, Stephanie Heyman, Vittorio Iacovella, Amanda F. Mejia, Daniele Marinazzo, R. Cameron Craddock, Emanuale Olivetti, Jamie L. Hanson, Eleftherios Garyfallidis, Dan Stanzione, James Carson, Robert Henschel, David Y. Hancock, Craig A. Stewart, David Schnyer, Damian O. Eke, Russell A. Poldrack, Steffen Bollmann, Ashley Stewart, Holly Bridge, Ilaria Sani, Winrich A. Freiwald, Aina Puce, Nicholas L. Port, Franco Pestilli

Psychological Science Faculty Publications and Presentations

Neuroscience is advancing standardization and tool development to support rigor and transparency. Consequently, data pipeline complexity has increased, hindering FAIR (findable, accessible, interoperable and reusable) access. brainlife.io was developed to democratize neuroimaging research. The platform provides data standardization, management, visualization and processing and automatically tracks the provenance history of thousands of data objects. Here, brainlife.io is described and evaluated for validity, reliability, reproducibility, replicability and scientific utility using four data modalities and 3,200 participants.

What Factors Within The Context Of A Romantic Relationship And The Couple’S Finances Are Related To The Level Of Religiosity Among Contemporary Emerging Adults?, Brandan E. Wheeler, Joe D. Wilmoth, Tommy M. Phillips, Cecilia Brooks

Journal of Human Sciences and Extension

Research has identified the beneficial nature of spirituality/religiosity towards people’s general, psychological, and relational well-being despite a decline in religiosity among Americans, particularly among the younger generations. Research also suggests religiosity influences important relational factors, such as entering cohabiting relationships, but that these relational factors may also influence participants’ level of religiosity in a reciprocal effect. Therefore, the purpose of the current study was to explore how demographic, relational, and financial factors influence young adults’ level of religiosity within the context of a romantic relationship and the couples’ finances. Results from the current study suggest the length of the relationship …

‘Why Don’T You Just Marry A Farmer?’: Barriers And Challenges Experienced By Women Farm Owners In Georgia, Abby E. Green, Dan B. Croom, M'Randa R. Sandlin, Anna Scheyett

Journal of Human Sciences and Extension

This research explores the resilience of women farm owners in Georgia amidst societal gender inequality and discrimination. The study identifies barriers women face as farm owner-operators and strategies they use to overcome these obstacles. A two-stage interview process focused on participants’ life histories and reflections on their experiences. The study reveals significant challenges for women in farming, including gender discrimination, the knowledge required to farm, and the dichotomy between farming and home responsibilities. Gender discrimination is prevalent, with women having to prove their legitimacy as farmers. The need to acquire farming knowledge quickly was another significant barrier. The study aligns …

A Mindful And Sustainable Eating Intervention To Improve Attitudes Related To Mindfulness, Sustainability, And Fruit And Vegetable Consumption In Elementary Schools, Amy Schachtner-Appel, Heejung Song

Journal of Human Sciences and Extension

Excessive plate waste is generated in elementary school cafeterias. Adapting nutrition promotion strategies to target waste reduction and encouraging mindful and sustainable eating (MSE) are possible strategies to encourage students to reduce waste during school lunch. Farm to Tray, Tray to Farm is a 16-week intervention that aims to encourage elementary school students to develop mindful and sustainable eating behaviors. An educational curriculum was delivered to eight 5th-grade students, who served as peer leaders and disseminated messages throughout the school. Additional strategies included cafeteria reinforcements and opportunities for food recovery. A pilot test of the program was conducted in two …

Voices Of The Future: A Healing Ethno-Racial Trauma Approach To Financial Education Within African American Communities, Tonia Brinston, Chalandra M. Bryant, Sharon E. Powell, Joyce Serido

Journal of Human Sciences and Extension

In this article, we describe the process we adopted in designing a financial education intervention situated within the cultural and systemic realities of structural racism in Black communities and offer new insights on conducting financial education that addresses healing from ethno-racial trauma. We adopted a community-based participatory research (CBPR) approach and assembled a Community Led Advisory (CLA) group to discuss how to address social and economic inequalities in teaching financial education. Specifically, we sought to address the psychological consequences of racism, income scarcity, and other forms of economic distress and what it means for people’s lives and their everyday ability …

Multigenerational Consequences Of Environment And Loss On Maternal Behavior, Anxiety, Boldness, And Memory In Rats, Alayna Palamar

Longwood Senior Theses

Maternal behavior has long been studied for the implications it presents for offspring outcomes. In the present study, we examined the interplay between the positive effects of environmental enrichment and the negative consequences of loss – defined as a 50% litter cull – on both mothers and their offspring. In this multigenerational study, maternal Sprague Dawley rats were separated into one of four of the following conditions: enriched/control, enriched/loss, standard/control, and standard/loss. Maternal rats (P generation) were assessed using the following behavioral assays: Elevated Plus Maze (EPM) for anxiety-like behavior and boldness, Object Location Maze (OLM) for spatial memory, and …

Gamma Sigma Delta, Nebraska Chapter Newsletter, Issue #64 Spring 2024

Gamma Sigma Delta, Nebraska Chapter: Newsletters

President-Elect's message, John R. Ruberson

Nominations form for Gamma Sigma Delta, Nebraska chapter

2023 Outstanding Graduate Student Award nominations solicitation

2023 Teaching Award nominations solicitation

2023 Research Award nomination solicitation

2023 Extension Award nomination solicitation

2023 Award of Merit nomination solicitation

Annual dues notice

List of active members with expiration terms

Membership renewal form

Outstanding Graduate and Undergraduate Student Award fund solicitation

In memoriam:

Raymond "Gene" White (October 10, 1930-May 28, 2021)

ΓΣΔ pledge

Una Exploración Sobre La Alimentación Saludable. Percepciones De Mujeres Adultas Entre 31 Y 45 Años Según Su Nivel De Ingresos En La Ciudad Autónoma De Buenos Aires En 2024 / An Exploration Of Healthy Eating. Perceptions Of Adult Women Between 31 And 45 Years Old According To Their Income Level In The Autonomous City Of Buenos Aires In 2024, Anabelle Flaharty

Independent Study Project (ISP) Collection

En los últimos años, Argentina ha identificado los hábitos alimentarios como un área crítica que necesita análisis e intervención. Dado que la desnutrición es una de las principales causas de enfermedades no transmisibles (ENTs), organizaciones mundiales de salud han afirmado que practicar una “alimentación saludable” es una solución práctica a este problema. Entre la población argentina, la alimentación poco saludable ha provocado una epidemia de obesidad, sobrepeso y ENTs. Se sabe que hoy el 31,7 % de las mujeres argentinas adultas y el 30,2 % de los hombres argentinos adultos tienen sobrepeso. Además, la diabetes tiene una prevalencia del 10,5% …

Undergraduate Instruction In Plant Pathology: In-Class Group Activities Improve Teamwork Skills In Semester-Long Projects, Teddy Garcia-Aroca

UNL Faculty Course Portfolios

PLPT 210: Plant Pathogens and Disease is an introductory-level undergraduate course offered by the Department of Plant Pathology at University of Nebraska-Lincoln. The course covers the basic principles of plant pathology, fundamental aspects of pathogen biology, and common management strategies. The course is offered every spring, and the enrollment is ~40 students per semester. Most students enrolled in the course are sophomores, juniors, to a lesser extent seniors from the Agronomy and Horticulture majors, Plant and Landscapes Systems, and Environmental Sciences. The course consists of lectures and in-class activities, and students are evaluated through quizzes, individual and in-group homework assignments, …

An Exploration Of The Genetics Of The Mutant Huntingtin (Mhtt) Gene In A Cohort Of Patients With Chorea From Different Ethnic Groups In Sub-Saharan Africa, Mendi J. Muthinja, Carlos Othon Guelngar, Maouly Fall, Fatumah Jama, Huda Aldeen Shuja, Jamila Nambafu, Daniel Gams Massi, Oluwadamilola Ojo, Juzar Hooker, Dilraj Sokhi

Internal Medicine, East Africa

Background: Africans are underrepresented in Huntington's disease (HD) research. A European ancestor was postulated to have introduced the mutant Huntingtin (mHtt) gene to the continent; however, recent work has shown the existence of a unique Htt haplotype in South-Africa specific to indigenous Africans.

Objective: We aimed to investigate the CAG trinucleotide repeats expansion in the Htt gene in a geographically diverse cohort of patients with chorea and unaffected controls from sub-Saharan Africa.

Methods: We evaluated 99 participants: 43 patients with chorea, 21 asymptomatic first-degree relatives of subjects with chorea, and 35 healthy controls for the presence of the mHtt. Participants …

Long-Term Health Related Quality Of Life Following Uterine Fibroid Embolization In A Predominantly Black African Population: A Retrospective Cohort Study, Michael Kioko, Marleen Temmerman, Timona Obura, Adelaide Lusambili

Obstetrics and Gynaecology, East Africa

Uterine Fibroid Embolization (UFE) is one of the effective options available for treatment of symptomatic uterine fibroids with documented improvement in the quality of life and reduction in symptoms. The study assessed long-term quality of life post-uterine fibroid embolization in a mostly black population, noting scanty local or African research on this topic despite evidence suggesting a higher fibroid burden among black women. This retrospective study examined patients who underwent UFE from 2009 to 2014. Participants completed online demographic and UFS-QOL surveys. Statistical tests included Wilcoxon signed rank tests for HRQOL score differences and Pearson correlation for associations between independent …

Alfred Russel Wallace Notes 30. Wallace A Theist? Part I., Charles H. Smith

Faculty/Staff Personal Papers

Alfred Russel Wallace (1823−1913) has been portrayed as a ‘theist’ on a large number of occasions from his own time on to the present. In this, the first of a two part work, this assessment is questioned. In part one, the matter of Wallace’s personal philosophy and spiritual orientation is explored, the conclusion being that Wallace was a lifelong agnostic who can hardly be aligned with theism.

The Effects Of Phenological Shifts On The Reproductive Success Of Common Terns (Sterna Hirundo) And Arctic Terns (Sterna Paradisaea) In The Gulf Of Maine, Jamie W. Dinella

Student Publications

Climate change is resulting in ecosystem-wide consequences, including shifts in the geographical distribution of species and the timing of biological events, or phenology. The rapidly warming Gulf of Maine hosts breeding populations of migratory common terns (Sterna hirundo) and Arctic terns (Sterna paradisaea). I used nest check data (2013-2022) and eggshell membrane stable isotope data (2022) from Petit Manan Island in the Gulf of Maine to examine the causes and consequences of variation in phenology in common and Arctic terns. I hypothesized that the timing of an individual’s breeding was impacted by their foraging behavior and that female terns that …

Investigating Essential Oils, Natural Compounds, And Marine Based Rumen Buffers As Feed Additives For Enteric Methane Mitigation And Improved Ruminant Productivity, Ian Hodge

Theses

Ruminant dietary additives were investigated for enteric methane (CH4) mitigation and their effects on rumen fermentation characteristics during both in vitro and in vivo supplementation trials. A meta-analysis of the peer reviewed published literature was initially performed to establish the state of the art in the field and allowed benchmarking of the performance of the dietary additives screened during the project. Investigated feed additives included garlic oil (GO), nitrate, Ascophyllum nodosum (AN), Asparagopsis (ASP), Lactobacillus plantarum (LAB), calcareous marine algae (CMA), chitosan (CHI), essential oils (EO) and 3-nitrooxypropanol (3-NOP). The development of an in vitro screening method to evaluate the …

Growing South Dakota (Spring 2024), College Of Agriculture, Food And Environmental Sciences

Growing South Dakota (Publication of the College of Agriculture, Food and Environmental Sciences)

[Page] 3 Empowering the Next Generation of Agriculture
/="/">[Page] 5 Celebration of Faculty Excellence
/="/">[Page] 7 Judging Teams Provide Connection, Critical Skills
/="/">[Page] 11 Melanie Caffe: SDSU Oat Breeder Finds Motivation in Making a Difference for Farmers
/="/">[Page] 13 2024 CAFES Outstanding Seniors
/="/">[Page] 14 SDSU Celebrates Students Accepted to Veterinary Schools through Stethoscope Ceremony"
/="/">[Page] 15 New Researchers in CAFES
/="/">[Page] 17 Hitting the Mark – Shooting Sports Driving Growth in SDSU Extension 4-H Program
/="/">[Page] 19 A New Century Leads to a New Barn
/="/">[Page] 20 CAFES News & …

Post-Vaccination Sars-Cov-2 Igg Spike Antibody Responses Among Clinical And Non-Clinical Healthcare Workers At A Tertiary Facility In Kenya, Lucy Wangari, Geoffrey Omuse, Rodney Adam, George Ongete, Cyrus Matheka, Patrick Mugaine, Shahin Sayed, Daniel Maina

Pathology, East Africa

Introduction: Following the coronavirus disease 19 (COVID-19), caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection, vaccination became the main strategy against disease severity and even death. Healthcare workers were considered high-risk for infection and, thus, were prioritised for vaccination.

Methods: A follow-up to a SARS-CoV-2 seroprevalence study among clinical and non-clinical HCWs at the Aga Khan University Hospital, Nairobi, we assessed how vaccination influenced SARS-CoV-2 anti-spike IgG antibody responses and kinetics. Blood samples were drawn at two points spanning 6 to 18 months post-vaccination, and SARS-CoV-2 spike antibody levels were determined by enzyme-linked immunosorbent assay.

Results: Almost all participants, …

Pilot Study: Effects Of Whole Body Vibrational Therapy On Equine Epaxial Muscle Soreness, Riley Leibeck

Undergraduate Honors Thesis Projects

Whole body vibrational therapy (WBV) is well-studied in people, but there is a paucity of research of its effect on horses. It is suggested that WBV use in horses increases performance, aids in recovery, and stimulates nerves, bones, and muscles in ways that normal exercise does not. The purpose of this pilot study was to determine if frequent WBV therapy sessions affect back soreness in horses using pressure algometry. Most sporthorses will experience back soreness in their careers, and it is regarded as one of the most common causes of poor performance in equine athletes. Five horses were measured for …

Improving Fertility While Synchronizing Estrus In Beef Heifers When Feeding Mga, Anisa Olavarria

Honors Theses

Melengestrol Acetate (MGA) is used to suppress estrus in cattle and is used to synchronize estrus. However, when fed to beef cattle during the absence of a corpus luteum, a transient progesterone producing organ after ovulation, the dominant follicle is unable to regress becoming persistent resulting in decreased fertility of the oocyte. In this study, two treatment protocols were designed to test if administering GnRH, a hormone used to induce ovulation resulting in the formation of a corpus luteum at the beginning of the MGA feeding will prevent fewer persistent follicles and improve the fertility of the ovulation immediately following …

Behavioral Response Of Commercial Cattle To Common Handling Methods In Pasture Settings, Agustin Angel Espinoza

Honors Theses

Flight zones can be described as the personal space bubble of cattle. Cattle will make attempts to retain this personal space bubble when being approached in a pasture setting. Flight zone distance can be used by producers to understand cattle temperament. A larger flight zone may indicate a more excitable temperament. In this study female cattle aged 1-12 were approached on foot, by utility vehicle and by feed truck in a pasture setting to record their flight zone. This study evaluated how differing methods of approach affect the flight zone. Low stress handling was the method of approach taken to …

Impact Of Temperature On The Bionomics And Geographical Range Margins Of The Two-Spotted Field Cricket Gryllus Bimaculatus In The World: Implications For Its Mass Farming, Henlay J.O. Magara, Chrysantus M. Tanga, Brian L. Fisher, Abdelmutalab G.A. Azrag, Saliou Niassy, James P. Egonyu, Sylvain Hugel, Nana Roos, Monica A. Ayieko, Subramanian Sevgan, Sunday Ekesi

All Peer-Reviewed Publications

Gryllus bimaculatus (Orthoptera: Gryllidae) is widely considered an excellent nutrient source for food and feed. Despite its economic importance, there is limited information on the impact of temperature on the bionomics of this cricket to guide its effective and sustainable mass production in its geographical range. The biological parameters of G. bimaculatus were investigated at eight different temperatures ranging from 20–40∘C. The Insect Life-Cycle Modelling (ILCYM) program was used to fit linear and non-linear functions to the data to describe the influence of temperature on life history parameters and its farmability under the current and projected climate for 2050. Our …

A Review On Irisin, The Beta 3-Adrenergic Receptor, And Zinc Alpha 2-Glycoprotein’S Impact On Metabolic Health, Dawson Troutman

Honors College Theses

This thesis aims to provide insight into how Irisin, the beta 3-adrenergic receptor, and zinc alpha 2-glycoprotein can impact human metabolism. Analyzing studies on the impact these species have on thermogenesis and lipolysis help provide a clearer picture on their use in potential management of metabolic issues.

Adsorbents From Rice Husk And Shrimp Shell For Effective Removal Of Heavy Metals And Reactive Dyes In Water, Firoz Ahmed, Masoumeh Zargar

Faculty, Staff and Student Publications

Widespread contamination by heavy metals (HMs) and dyes poses a major health risk to people and ecosystems requiring effective treatment. In this work, rice husk (RH) and shrimp shells were extracted to obtain amorphous silica and chitosan, respectively, which were utilized to produce nano-chitosan-coated silica (NCCS). To ensure the stability of the nanoparticles, silica was freeze-dried after being coated with nano-chitosan. Functional groups (-NH

Design, Protocol And Baseline Data Of Nurturing Healthy Teachers, A Cluster Non-Randomized Controlled Trial To Improve The Health, Well-Being, And Food Security Of Preschool And Elementary School Teachers In Houston, Texas, Ru-Jye Chuang, Azar Gaminian, Jill Cox, Katherine French, Nalini Ranjit

Faculty, Staff and Student Publications

BACKGROUND: We present the conceptual framework, design, and study measures of Nurturing Healthy Teachers, a quasi-experimental study to examine the short- and long-term effectiveness of the Nurturing Healthy Teachers (NHT) nutrition intervention on food insecurity, dietary behaviors, mental health and cardiometabolic health among preschool and elementary school teachers.

METHODS: A convenience sample of 28 elementary schools with pre-kindergarten and elementary classrooms were recruited in Houston, Texas. Nurturing Healthy Teacher intervention includes Brighter Bites, an evidence-based coordinated school health program that combines access to fresh produce and nutrition education, and Create Healthy Futures, a web-based nutrition education program that targets nutrition …

Serum Metabolomic Markers Of Protein-Rich Foods And Incident Ckd: Results From The Atherosclerosis Risk In Communities Study, Lyn M Steffen, Andrew S Levey, Morgan E Grams, Eugene P Rhee, Casey M Rebholz

Faculty, Staff and Student Publications

RATIONALE & OBJECTIVE: While urine excretion of nitrogen estimates the total protein intake, biomarkers of specific dietary protein sources have been sparsely studied. Using untargeted metabolomics, this study aimed to identify serum metabolomic markers of 6 protein-rich foods and to examine whether dietary protein-related metabolites are associated with incident chronic kidney disease (CKD).

STUDY DESIGN: Prospective cohort study.

SETTING & PARTICIPANTS: A total of 3,726 participants from the Atherosclerosis Risk in Communities study without CKD at baseline.

EXPOSURES: Dietary intake of 6 protein-rich foods (fish, nuts, legumes, red and processed meat, eggs, and poultry), serum metabolites.

OUTCOMES: Incident CKD (estimated …

A Multitrait Genetic Study Of Hemostatic Factors And Hemorrhagic Transformation After Stroke Treatment, Natalia Cullell, Jesús M Martin-Campos, Tomás Sobrino, José Castillo, Mònica Millán, Lucía Muñoz-Narbona, Elena López-Cancio, Marc Ribó, Jose Alvarez-Sabin, Jordi Jiménez-Conde, Jaume Roquer, Silvia Tur, Victor Obach, Juan F Arenillas, Tomas Segura, Gemma Serrano-Heras, Joan Marti-Fabregas, Marimar Freijo-Guerrero, Maria Del Mar Castellanos, Alanna C Morrison, Nicholas L Smith, Paul S De Vries, Israel Fernández-Cadenas, Maria Sabater-Lleal

Faculty, Staff and Student Publications

BACKGROUND: Thrombolytic recombinant tissue plasminogen activator (r-tPA) treatment is the only pharmacologic intervention available in the ischemic stroke acute phase. This treatment is associated with an increased risk of intracerebral hemorrhages, known as hemorrhagic transformations (HTs), which worsen the patient's prognosis.

OBJECTIVES: to investigate the association between genetically determined natural hemostatic factors' levels and increased risk of HT after r-tPA treatment.

METHODS: Using data from genome-wide association studies on the risk of HT after r-tPA treatment and data on 7 hemostatic factors (factor [F]VII, FVIII, von Willebrand factor [VWF], FXI, fibrinogen, plasminogen activator inhibitor-1, and tissue plasminogen activator), we performed …

Unveiling Gene Interactions In Alzheimer's Disease By Integrating Genetic And Epigenetic Data With A Network-Based Approach, Xiangning Chen, Zhongming Zhao

Faculty, Staff and Student Publications

Alzheimer’s Disease (AD) is a complex disease and the leading cause of dementia in older people. We aimed to uncover aspects of AD’s pathogenesis that may contribute to drug repurposing efforts by integrating DNA methylation and genetic data. Implementing the network-based tool, a dense module search of genome-wide association studies (dmGWAS), we integrated a large-scale GWAS dataset with DNA methylation data to identify gene network modules associated with AD. Our analysis yielded 286 significant gene network modules. Notably, the foremost module included the BIN1 gene, showing the largest GWAS signal, and the GNAS gene, the most significantly hypermethylated. We conducted …

Digital Health Technologies For High-Risk Pregnancy Management: Three Case Studies Using Digilego Framework, Amy Franklin, Deevakar Rogith, Jerrie Refuerzo

Faculty, Staff and Student Publications

OBJECTIVE: High-risk pregnancy (HRP) conditions such as gestational diabetes mellitus (GDM), hypertension (HTN), and peripartum depression (PPD) affect maternal and neonatal health. Patient engagement is critical for effective HRP management (HRPM). While digital technologies and analytics hold promise, emerging research indicates limited and suboptimal support offered by the highly prevalent pregnancy digital solutions within the commercial marketplace. In this article, we describe our efforts to develop a portfolio of digital products leveraging advances in social computing, data science, and digital health.

METHODS: We describe three studies that leverage core methods from

RESULTS: Scalable social computing models using deep learning classifiers …

Identification Of Novel F2-Isoprostane Metabolites By Specific Udp-Glucuronosyltransferases, Warda Amin, Sarah Thomas, Camille Oger, Jean-Marie Galano, Harvey J Murff, Gong Yang, Thierry Durand

Faculty, Staff and Student Publications

UDP-glucuronosyltransferases (UGTs) catalyze the conjugation of glucuronic acid with endogenous and exogenous lipophilic small molecules to facilitate their inactivation and excretion from the body. This represents approximately 35 % of all phase II metabolic transformations. Fatty acids and their oxidized eicosanoid derivatives can be metabolized by UGTs. F2-isoprostanes (F2-IsoPs) are eicosanoids formed from the free radical oxidation of arachidonic acid. These molecules are potent vasoconstrictors and are widely used as biomarkers of endogenous oxidative damage. An increasing body of evidence demonstrates the efficacy of measuring the β-oxidation metabolites of F2-IsoPs rather than the unmetabolized F2-IsoPs to quantify oxidative damage in …

Social And Behavior Factors Of Alzheimer's Disease And Related Dementias: A National Study In The Us, Yinan Zheng, Hua Xu, Xiaoqian Jiang, Kun Huang, Kelley Pettee Gabriel, Hong-Wen Deng, Mary P Gallant, Kai Zhang

Faculty, Staff and Student Publications

Introduction: Considerable research has linked many risk factors to Alzheimer's Disease and Related Dementias (ADRD). Without a clear etiology of ADRD, it is advantageous to rank the known risk factors by their importance and determine if disparities exist. Statistical-based ranking can provide insight into which risk factors should be further evaluated.

Methods: This observational, population-based study assessed 50 county-level measures and estimates related to ADRD in 3,155 counties in the U.S. using data from 2010 to 2021. Statistical analysis was performed in 2022-2023. The machine learning method, eXtreme Gradient Boosting, was utilized to rank the importance of these variables by …