Life Sciences Commons^™

Integrating Technologies For Synthetic, Systems, And Spatial Approaches In Cancer Research, Karmella A. Haynes, Kolade Adebowale, Belinda S. Akpa, Joel S. Bader, Trisha Bansal, Joshua Breunig, Ran Brosh, Lukasz J. Bugaj, George M. Burslem, Awalpreet Chadha, Moumita Das, Tara Deans, Cole A. Deforest, Lawrence J. Dooling, Zev Gartner, Laura M. Heiser, Alex Hughes, Melissa L. Kemp, Kirill S. Korolev, Chunru Lin, Timothee Lionnet, Xin Lu, Alison P. Mcguigan, Hamid Reza Mirzaei, Ajit J. Nirmal, Marina Pasca Di Magliano, Alexandros Poulopoulos, Kunal Rai, José Reyes, Dagan Segal, Mary Kathryn Sewell-Loftin, Evegeniya V. Shmeleva, Adam Stevens, Subbaya Subramanian, Thea Tlsty, Jennifer Totonchy, Alexander Vlahos, Pei Wang, Ioannis K. Zervantonakis, Yanding Zhao

Pharmacy Faculty Articles and Research

Emerging tools for spatial analysis, systems biology, and synthetic biology offer opportunities to observe, dissect, and perturb cancer mechanisms, to design strategies for the prevention of oncogenesis, and to identify therapies that lead to durable tumor control. Here, we summarize perspectives from the virtual Innovation Lab on “Synthetic and Systems Approaches to Interrogate Spatiotemporal Processes in Cancer” (S3) hosted by the National Institutes of Health (NIH), which assembled interdisciplinary experts to discuss cancer spatial organization and dynamic cellular interactions and how they can be addressed by leveraging novel synthetic and systems biology approaches. These discussions focused especially on cancer initiation, …

Development Of Gluten-Free Cookies Produced From Blends Of Chickpea Flour And Soybean Flour With Rice Flour, Cao Thi Bich Thao, Diana Widiastuti, Chau Minh Thuan, Nguyen Ngoc Thanh Tien, Pham Van Hung

Chimica et Natura Acta

The incorporation of chickpea and soybean flours may improve the nutritional quality of gluten-free cookies, particularly their protein and resistant starch contents. This study investigated the effects of various levels of chickpea or soybean flour (10%, 30%, and 50% w/w) substituted to rice flour on the physicochemical and pasting properties of composite flours, and cookie quality, resistant starch, and sensory properties of gluten-free cookies were evaluated. Proximate analysis revealed that fortification increased the protein from 6.8% to 22.36% in the composite flours. The composite flours showed lower swelling index and higher water absorption capacity than rice flour and both peak …

Community-Based Water Management Through Cultural Ecosystem Services: Traditional Wisdom And Modern Adaptation In Senjoyo Spring, Indonesia, Puji Winarti, Sri Haryani, Sri Wardani, Langlang Handayani

Journal of Environmental Science and Sustainable Development

Small-scale freshwater ecosystems play vital ecological and cultural roles. However, community-based water management (CBWM) often lacks a clear analytical approach to integrating cultural ecosystem services (CES) and traditional ecological knowledge (TEK), limiting the practical understanding of culturally grounded governance. To address this gap, this qualitative study explores the interactions between CES and TEK, analyzes their roles within CBWM, and identifies their implications for sustainable water governance. The integration between cultural value and local ecological knowledge makes Senjoyo Spring an appropriate location for this study. Data were collected through interviews with 20 key informants, field observations, forum group discussions (FGDs), and …

Community-Based Well Testing And Outreach To Mitigate Human Health Risk From Unsafe Drinking Water, W. Adam Sigler, Katharine Sutphen, Margaret J Eggers, Kaleena Miller, Michelle Grocke-Dewey

Journal of Extension

Twenty-two percent of groundwater wells tested nationwide have one or more contaminants above a health threshold, yet many private well owners are unaware of these risks because they have not tested their water. Researchers piloted a community well testing clinic for education/outreach and surveyed participants about outcomes. Two months later, 75% of participants with high or intermediate health risk water quality results had taken action or intended to, indicating that community private well testing clinics can be effective in mitigating human health risks from contaminated drinking water.

Educating Livestock Producers And Monitoring The Ecological Health Of Grazing Spaces, Morgan Mathisonslee, Matt R. Raven, Crista Derry

Journal of Extension

Addressing the climate catastrophe requires a systems approach with a focus on regenerating agricultural landscapes. To address these complex problems, we offered a monitoring training focused on a systems approach to livestock stewardship using the Savory Institute's Ecological Outcomes Verification protocol to monitor ecosystem health. The training encouraged producers to use systems-based management practices to promote ecological regeneration. We found that despite producers not adopting the monitoring protocol, there were increases in the ecological health of their farms. We suggest Extension professionals consider teaching similar ecological monitoring protocols to benefit producers and support claims about regenerative agriculture.

Market Trends And Challenges For Alabama's Emerging Oyster Aquaculture Industry, Taryn M. Garlock, Quinn Lafontaine, Russell Grice, Andrea M. Tarnecki

Journal of Extension

Different marketing channels influence farm profitability by affecting the costs that producers incur and the prices they receive. This article quantifies oyster sales volume and price by market channel in Alabama's commercial oyster aquaculture sector and assesses challenges to expanding farm businesses. The results show that many oyster producers are selling exclusively through one channel, which raises questions about their resiliency and their capacity to adapt to a dynamic single market. The two most common market channels were processors and distributors. Most growers had a positive outlook on sales growth and showed the greatest interest in expanding sales to distributors, …

Creating Sustainable School And Home Gardens: Gardening Indoors, Rita Hagevik, Kathy Cabe Trundle

All Current Publications

Extending your growing season is a great way to produce more food earlier in spring, later in fall, or even during winter. One of the best ways to do this is to use indoor gardening and greenhouse systems, which let you grow plants beyond what is possible outdoors or alongside outdoor growing. This guide focuses on soil-based indoor gardening.

Pi3kδ Inhibition Alters Cd8 T Cell Differentiation And Reprograms The Tumor Microenvironment Following Adoptive Immunotherapy, Alexandrea Joy Turnquist

Dartmouth College Ph.D Dissertations

T cell exhaustion remains a significant barrier to effective adoptive cell therapy in solid tumors. Here, we demonstrate that in vitro treatment with the PI3Kδ inhibitor CAL-101 generates T cells with enhanced stemness and metabolic fitness, though the stemness of these cells is not dependent on HIF-1α -dependent mechanisms. These cells show increased mitochondrial dependence and spare respiratory capacity while maintaining normal basal metabolism. Under chronic antigen stimulation, CAL-101-treated T cells, including human T cells, resist terminal exhaustion and maintain stem-like properties. Using single-cell RNA sequencing and spatial transcriptomics of B16 melanoma tumors, we found that CAL-101-treated T cells preferentially …

Marine Spatial Planning In The Asean Countries: Lesson Learned For Future Ocean Governance In Malaysia, Husni Alhan Md Salimun, Mohd Fadzil Akhir, Nazli Aziz, Che Din Mohd Safuan, Wan Izatul Asma Wan Talaat

Journal of Environmental Science and Sustainable Development

Marine Spatial Planning (MSP) has emerged as an important governance instrument for balancing ecological protection, economic development, and social inclusion amid the rapidly intensifying blue economy in Southeast Asia. Although several ASEAN Member States (AMS) have initiated MSP processes, the existing literature on MSP governance in this region  remains fragmented and largely descriptive, limiting systematic cross-country comparison and evidence-based lessons. This study addresses this gap by assessing MSP governance performance across ASEAN countries and againts internationally recognized MSP governance benchmarks. A structured narrative review was conducted using selected PRISMA-informed procedures for literature identification and screening. Academic publications from 2003 to …

Changing Ocean Chemistry: Impacts Of Ocean Deoxygenation And Acidification From Benthic Iron Fluxes To Fisheries, De'marcus Robinson

DoMES Seminar Series

Ocean deoxygenation and acidification are impacting marine ecosystems, contributing to changes in ocean biogeochemical cycling and fisheries across the U.S. West Coast and northern Gulf of America/Mexico. Using spatially and temporally resolved observations, numerical modeling, and biogeochemical analyses, this seminar examines how changing ocean conditions influence processes from water-column oxygen dynamics to marine organisms. In the Santa Barbara Basin, observations of dissolved O₂ reveal persistent decadal hypoxic and anoxic conditions and changes in deep-water ventilation associated with high benthic iron fluxes (0.23–4.9 mmol m⁻² d⁻¹). Combining benthic iron flux measurements with numerical simulations demonstrates how iron availability can enhance surface …

Decentralized Renewable Energy And Sustainability By Integrating Solar Ovens Into Urban Living, Nuno Soares Domingues

Journal of Environmental Science and Sustainable Development

Urban households account for a substantial share of global energy consumption and greenhouse gas emissions, with domestic cooking representing an often-overlooked component of residential energy demand. Low-cost solar cooking technologies offer a promising pathway towards urban decarbonization by harnessing renewable solar energy while reducing dependence on grid electricity and promoting circular resource use. This study evaluates the contribution of two experimentally developed low-cost solar box ovens to urban sustainability under Mediterranean climatic conditions in Lisbon, Portugal. A recycled cardboard prototype and a timber-based prototype were assessed through controlled outdoor experiments involving thermal performance, cooking capability, energy savings, and environmental evaluation. …

Improving Market Acceptance Of Agrivoltaic Implementation In Japan, Divya Suresh, Yuxin Qin, Kenichiro Hiramoto, Takuma Otaki, Abhishek Choudhury, Xiao Chen, Rajib Shaw

Journal of Environmental Science and Sustainable Development

Agrivoltaics (AV) enables the simultaneous use of land for solar energy generation and agricultural production. While AV has been widely studied from technical and economic perspectives, limited attention has been paid to market acceptance among farmers, particularly in Japan, where adoption remains constrained despite policy interest in renewable energy and rural revitalization. Existing studies identify regulatory, financial, and technical barriers, but insufficiently explain how farmer-level acceptance is shaped across different agricultural contexts or how project co-benefits can support adoption. This study examines farmers’ market acceptance of AV in Japan through a multi-case analysis of six projects in rice-cultivation areas, mountainous …

Good Governance In The Concept Of Climate Justice: Decarbonisation Policies In Economic Considerations Of Losses And Sacrifices, Daryanti Daryanti, Albertus Sentot Sudarwanto, Erna Dyah Kusumawati, Rosita Candrakirana

Journal of Environmental Science and Sustainable Development

Projections of losses resulting from the impacts of climate change in Indonesia are estimated to reach USD 30.5 million, affecting four key sectors: agriculture, water supply, health, and the maritime sector. This study shows that good governance based on climate justice in the implementation of decarbonization policies is the most important factor in avoiding long-term economic losses caused by the adverse impacts of climate change or investing in climate resilience. This study employed a normative methodology using a statutory approach to examine efforts related to climate change mitigation and adaptation. The findings of this research indicate that regulations in Indonesia, …

Climate Change Mitigation And Forest Conservation: A Sdg-Aligned Framework For Malaysia, Hui Nee Au Yong, Chuan Chew Foo, Maryam Kalhoro, Irfan Rashdi

Journal of Environmental Science and Sustainable Development

Climate change and biodiversity loss are interlinked global crises that require integrated governance approaches, particularly in biodiversity-rich countries such as Malaysia. This study develops and empirically tests a climate biodiversity sustainable development goal (SDGs) nexus model that integrates forest governance, carbon sequestration, Indigenous Ecological Knowledge (IEK), and sustainable practices to explain climate mitigation and biodiversity conservation outcomes. Survey data were collected from 412 respondents across Peninsular Malaysia, Sabah, and Sarawak using Partial Least Squares Structural Equation Modelling (PLS-SEM) to test the hypothesised relationships. The analysis examines direct, mediating, and moderating relationships among governance, social, technological, and policy factors. Forest governance …

Does Farm Size Matter In Agricultural Extension Programs? Insights From Us Agriculture Census Data, Pilja Vitale, Joshua Campbell, Jeffrey Vitale, Michael Patrick, John Garlisch

Journal of Extension

This commentary examines how farm size influences agricultural Extension programs in the United States, highlighting disparities between large and small farms. While large farms dominate production through advanced technologies and economies of scale, small farms are vital for food security, community well-being, and cultural preservation. Key differences include water use, labor, machinery, marketing, financial management, and food safety practices. Extension programs address these disparities through tailored initiatives such as financial literacy training for small farms and technology adoption workshops for large ones. This analysis emphasizes the need for targeted and inclusive Extension programming to enhance sustainability and equity across farm …

Virtual Natural Lighting Solutions (Vnls) Inside Hospitals And Its Psychological Impact, Asmaa Alaa Hasanein Hasanein, Alaa Shams Al-Din Al-Aishi, Marwa Atef Abd Elhady

Mansoura Engineering Journal

This study examines the correlation between daylighting environments in hospitals, users evaluations, and ways of bringing virtual natural light into inner spaces, highlighting the importance of good daylighting design for physical and psychological well-being. Virtual Natural Lighting Solutions (VNLS) mimic the balanced spectrum of natural light, bridging the gap between natural and artificial light, and are crucial for tasks, circadian rhythm, and mood in healthcare settings. The research addresses the variability and limitations of natural light, proposing VNLS for healthcare lighting design, especially in hospitals lacking daylight. The study aims to develop a methodology for using VNLS in healthcare environments …

Realities Of Engendering Federalization: Political Commitment To Gender Equality, Resources, And Policy, Christine S. Diaz

Journal of Public Affairs and Development

Amid several initiatives to federalize the Philippines, discourse on engendering federalization remains scarce. This gap forms the basis of this study, which examined the realities of engendering federalization. Data were gathered through in-depth interviews and key informant interviews with research participants from various sectors in Davao City. Guided by Caren Levy’s Web of Institutionalization Framework, the study focused on three core dimensions: political commitment to gender equality, resources, and policy. The findings revealed that engendering federalization, particularly political commitment to gender equality, requires advocacy, institutionalization, gender awareness, and gender-sensitivity formation. Institutional mechanisms, policies, and resources are important for advancing gender-responsive …

Weedy Vascular Plants Of The United States, James P. Smith Jr

Botanical Studies

No abstract provided.

Impacts Of Leonardite And Gibberellic Acid On Plant Stand And Ear Height In Early-Season Sweet Corn, Charlie Rohwer, Jesen Hosch

Midwest Vegetable Trial Reports

Sweet corn planted early in the season can suffer from poor germination due to low soil temperatures. In addition, low ear height of early-season hybrids can make hand- or machine-harvest more challenging. We tested impacts of two in-furrow leonardite treatments on germination and ear height, and a single application of a commercial gibberellic acid product (Proliant) on ear height. Sweet corn was planted on 5 May in southern Minnesota. We tested 14 sweet corn hybrids, including sugary-enhanced, synergistic, and supersweet. We found no impact of leonardite or Proliant on sweet corn stand or ear height. Three hybrids (‘Sprinter XR’, ‘Kickoff …

Adolescents’ Risk Of Long Covid-19 Syndrome Based On Income Level And Food Insecurity, Christopher J. Waskewich

Journal of Social, Behavioral, and Health Sciences

Limited information is available about the effects of food insecurity on adolescents’ long-term health risks from COVID-19. This quantitative, cross-sectional study aimed to examine the effects of food insecurity and family income level on the risk of long COVID-19 syndrome for adolescents (11 to 17 years old). An online survey (n = 298) was conducted with parents of adolescents from New York City, who were recruited from social media online advertisements. The research asked whether there is an association between food insecurity and family income level and the risks of long COVID-19 syndrome. Multivariate logistic regression found a statistically …

Horticultural Diplomacy: A Framework For Growing Culturally Aware Gardeners, Stephen Stresow-Cortez, Stephen Reiners, Ashley Miller Helmholdt

Journal of Extension

Derived from person-to-person diplomacy models, a ``horticultural diplomacy'' framework was implemented in a statewide vegetable variety trial program for two seasons to introduce Master Gardeners to diverse crops and cultures. Scaffolding learning with relevant recipes, bed groupings, community tasting events, and collecting community (citizen) science data helped participants build garden skills, gain a greater appreciation for other cultures, and inform new educational materials. Horticultural diplomacy is part of a deliberate effort aimed at growing food and building understanding among (primarily White) volunteers. The techniques that helped make this program successful, adaptable to other garden programs, and aspects that require improvements …

Equine Body Condition Scoring Flow Chart: A Field Guide, Robyn Stewart, Carissa Wickens, Brooklyne Wassel

Journal of Extension

The Equine Body Condition Scoring Flow Chart is a visual decision-making tool designed to guide users through the process of evaluating a horse's body condition score (BCS) using the Henneke scale. Accurately assessing BCS is critical for making informed management decisions relating to equine nutrition, health, and training. This tool simplifies the scoring process by breaking it down into step-by-step questions based on clear scoring criteria, anatomical landmarks, and both visual and tactile assessment. This tool can be used regardless of geographic location and benefits a diverse audience of Extension educators, horse owners, 4-H'ers, and equine business owners.

Global Stabilization Of The Mitochondrial Proteome Is Associated With Extreme Anoxia Tolerance In Austrofundulus Limnaeus Ws40ne Cells, Chelsea Hughes, Meranda M. Corona, Dietmar Kültz, Jason E. Podrabsky

Biology Faculty Publications and Presentations

Background: Austrofundulus limnaeus is an extremophile vertebrate native to small temporary ponds of Venezuela. Embryos of A. limnaeus must survive variable and often extreme conditions, including long periods of anoxia. Neuroepithelial cells derived from these embryos, WS40NE cells, provide a unique tool to understand how the proteome changes in response to anoxic stress. Results Using label-free proteomics, 19,604 peptides and 3487 proteins were quantified in normoxic, 4d anoxic, and 24 h recovery WS40NE cells. Of these, 2612 proteins (74.9%) were statistically significantly differentially abundant in at least one comparison: 1988 comparing normoxia to 4 days anoxia (57.0%), 923 comparing 4 …

The Impact Of Biophilic Design Patterns On Improving Thermal Comfort In Public Libraries Within Hot Arid Climates (A Case Study Of Misr Public Library - Aswan), Zainab Hassan Aljamily, Hatem Mahmoud Fathy, Breksam Hafez Elkess Boules

Mansoura Engineering Journal

Reading contributes to cognitive and cultural development, highlighting public libraries as educational and cultural spaces and emphasizing the need to improve their environmental performance. This study analyzes biophilic design patterns and thermal comfort in public libraries in hot arid climates, using Misr Public Library in Aswan as a case study. Despite growing interest in biophilic design, quantitative studies addressing its thermal impact remain limited. The research adopted an applied analytical methodology, including field measurements of temperature and relative humidity in the reading hall using a UT330TH/UT330THC data logger to verify simulation accuracy. Thermal performance was evaluated using DesignBuilder software before …

Applications Of Nanotechnology In Building Envelopes: An Analytical Study Of Environmental Performance And Architectural Form, Essam Salah Said Abdelmagid

Mansoura Engineering Journal

Contemporary architecture has witnessed a rapid evolution in the integration of nanotechnology within the design of building envelopes, due to its significant capability to enhance the physical and environmental properties of materials and to redefine the relationship between functional performance and architectural form. The building envelope is considered one of the most influential components affecting energy efficiency, indoor environmental quality,  and visual identity, which has made it a primary field for the application of nanomaterials and nanotechnologies.

This research aims to investigate and analyze the impact of nanotechnology applications in building envelopes on both environmental performance and architectural form through …

Artificial Sentience: From Computational Functionalism To Behaviourism?, Wanja Wiese

Animal Sentience

I critically examine Jonathan Birch’s account of how brain emulations might create artificial sentience candidates, arguing that his account risks collapsing into a behaviourist account, unless the specific computational processes realised by such emulations are carefully considered. Drawing on examples from computational neuroscience, I show that similar behaviours can arise from vastly different computational processes, thereby undermining the suggestion to focus on behaviourial profiles to determine whether a brain emulation of a sentience candidate is itself a sentience candidate.

Strategies To Transform Natural Resource Extension With Inaturalist And Engage The Public In Biodiversity Conservation, Corey T Callaghan, Brittany M Mason

Journal of Extension

Participatory citizen science is an increasingly popular tool that provides nonformal education and learning activities. iNaturalist, a free, open-access, participatory citizen science platform, provides a place to engage the public in natural resource programming. Here, we explore practical applications for integrating iNaturalist into Extension programming. We highlight two approaches: (a) self-guided programming, where participants independently engage in biodiversity documentation and professionals contribute identifications, and (b) facilitated programming, which involves structured events and projects led by Extension professionals. We discuss the unique advantages of using iNaturalist in these contexts and offer recommendations for quantitatively measuring and reporting its impact in Extension …

The Other Visual Acuity, Paul B. Freeman Od

Optometric Clinical Practice

Editorial

A Comprehensive Review Of Current Trends And Future Prospects In Drug Resistance Of Leishmania Species, Sarah Kamal Naser

Maaen Journal for Medical Sciences

Leishmaniasis, which is an infectious tropical disease that is caused by Leishmania protozoa, continues to be a leading global public health problem. This disease is prevalent in about 89 countries, with over one billion individuals being at risk of infection. Current treatments have many limitations, and the efficacy of currently available leishmanial drugs has been undermined by the development of resistant strains of Leishmania. This review highlights the prevailing patterns regarding drug resistance in Leishmania and looks forward to future ways to deal with this problem. The genomic plasticity seen in Leishmania, which includes aneuploidy, gene amplification, chromosome rearrangement, and …

Radiological And Chemical Safety Assessment Of Drinking Water From Treatment Plants And Rivers In Kut City, Iraq, Ahmed A. Alswaty, Hadi D. Alattabi

Karbala International Journal of Modern Science

Climate change and increasing anthropogenic activities, particularly wastewater discharge into rivers, have raised pollution levels in the water sources of Kut City, necessitating an assessment of the radiological and chemical safety of drinking water at the city's treatment plants. Thirteen water samples were collected, comprising ten treated and three raw water samples from the source rivers. An HPGe detector was used to measure the radionuclides ²¹⁴Bi, ²¹⁴Pb, ²¹²Bi, ²¹²Pb, ⁴⁰K, and ¹³⁷Cs. All measured radionuclides were below the minimum detectable activity (MDA). ICP-OES analysis supported these findings, as U concentrations in most samples were …