Life Sciences Commons^™

Elucidating The Luteal Microenvironment: The Role Of Fibroblasts In Luteal Regression, Corrine F. Monaco

Theses & Dissertations

The corpus luteum is a transient endocrine gland that produces progesterone, a steroid hormone needed for pregnancy. It is a heterogenous gland containing many different cell types: small and large steroidogenic cells, endothelial cells, immune cells, and fibroblasts. At the end of a non-fecund reproductive cycle, the corpus luteum undergoes cyclic regression, a process which is divided into two processes: 1) functional regression, in which progesterone production rapidly declines and 2) structural regression, in which the tissue undergoes rapid remodeling into a fibrotic scar called a corpus albicans. Although fibroblasts are well-known for their role in tissue remodeling, very little …

Identifying The Molecular Determinants Of Lung Metastatic Adaptation In Prostate Cancer, Grace M. Waldron

Theses & Dissertations

Prostate cancer (PC) stands as the primary diagnosed cancer in men in the US at approximately 299,010 cases in 2024 and ranks second globally, posing a significant public health challenge. Clinical presentations vary widely, from indolent to aggressive forms, necessitating stage-specific treatment regimens. Understanding its metastatic nature is critical due to the impact of cancer cell dissemination on disease morbidity, with bone and visceral organs serving as key sites of metastasis. Despite bone metastasis being the most common site for metastasis, visceral metastases at sites such as the liver and lungs correlate with poorer survival, emphasizing the role of microenvironmental …

The Relationship Between Amygdala And Orbitofrontal Cortex Volume In The Context Of Oppositional Defiant Disorder, Rahul Alla

Honors Scholar Theses

Disobedient and rebellious attitude in children is on the rise and this type of behavior is categorized as Oppositional Defiant Disorder (ODD). ODD in children can be identified as a persistent pattern of angry or irritable mood, argumentative or defiant behavior or vindictiveness toward others according to the Diagnostic and Statistical Manual (DSM-5, Fifth Edition) of Mental Disorders.1 Children with ODD typically have difficulty regulating and processing their emotions. Issues with regulating emotions is defined as the process by which individuals “influence which emotions they have, when they have them, and how they experience and express them”.2 Dysregulation of emotions …

Heavy Metals In Afforested Mangrove Sediment From The World's Largest Delta: Distributional Mapping, Contamination Status, Risk Assessment And Source Tracing, Sanjida Afrin Semme, Jimmy Yu, M Belal Hossain

Faculty, Staff and Student Publications

This study aims to assess seasonal and spatial variations, contamination status, ecological risks, and metal sources (Ni, Pb, Cr, Cu, Mn, and Zn) in human-afforested mangrove sediments in a deltaic region. Five sampling locations were sampled during dry and wet seasons. Heavy metal concentrations followed the order: Mn > Zn > Ni > Cr > Cu > Pb. Metal loads, except Cu and Pb, were higher during the dry season, aligning with national and international recommendations. Sediment quality guidelines, contamination factor, geoaccumulation index, enrichment factors, and pollution load index indicated uncontaminated sediment in both seasons. Potential ecological risk assessment showed low risk conditions in all …

Does Rural Transformation Affect Rural Income Inequality? Insights From Cross-District Panel Data Analysis In Bangladesh, Al Amin Al Abbasi, Subrata Saha, Ismat Ara Begum, Maria Fay Rola-Rubzen, Andrew M. Mckensie, Mohammad Janghir Alam

Agricultural Economics and Agribusiness Faculty Publications and Presentations

Rural transformation plays a crucial role in enhancing the income and employment prospects of the rural labor force. We investigate the effects of rural transformation on rural income inequality at the district level in Bangladesh using data from five years of nationally representative Household Income and Expenditure Surveys. The Gini coefficient is used to measure rural income inequality. In contrast, the share of high-value agricultural outputs and the share of rural non-farm employment are used as indicators of rural transformation. We find that rural income inequality is positively associated with the share of high-value agricultural outputs and the share …

The Effect Of Activated Alkaline Earth Bentonite On The Quality Of Vegetable Oils, Nodirbek I. Boyjanov, Islombek I. Boyjanov, Аslbek B. Yulchiev, Kamar P. Serkayev

CHEMISTRY AND CHEMICAL ENGINEERING

The purpose of the research is to study the adsorption properties and mineralogical structure of alkaline earth bentonites from the Navbakhor deposit, as well as to develop technological regimes for their acid activation for use as bleaching clay in the purification of vegetable oils. The authors, based on the structural structure of the studied bentonites, achieved an increase in adsorption capacity from 35 cm³/g to 100 cm³/g, by treating with hydrochloric and sulfuric acids with a concentration of 15-20% and in a bentonite:acid ratio of 1:2.5 at a temperature below 100°С. Nitrogen adsorption isotherms of activated …

Influence Of Lipolytic Enzymes On The Fractional Composition Of Wheat Alcohol, Bobir S. Kayumov, Saida Sh. Khakimova, Khasan T. Khasanov

CHEMISTRY AND CHEMICAL ENGINEERING

The purpose of this work is to study the influence of lipolytic enzymes on the fermentation activity and fractional composition of alcohol by the yeast Saccharamyces cerevisea during alcoholic fermentation. Lipolytic enzymes, intensifying the fermentation process and increasing the yield of the target product, have a positive effect on the physiological activity of yeast cells. Hydrolysis of carboxylic acid esters also occurs due to the hydrolase activity of lipases. In the presence of exogenous lipases, hydrolysis of lipids occurs due to the hydrolase activity of lipases and the fractional composition of alcohol changes. The content of esters is reduced by …

Selection Of Optimal Conditions For The Drying Process Of An Aqueous Extract From The Aerial Part Of Scutellaria Adenostegia, Shohida A. Ergasheva, Muniraxon A. Mamatxanova, Temurbek A. Khajibaev, Ravshanjon M. Khalilov, Akhmatkhon U. Mamatkhanov

CHEMISTRY AND CHEMICAL ENGINEERING

In order to establish optimal drying modes for an aqueous extract from the aboveground part of Scutellaria adenostegia, the following parameters were studied: solution concentration; solution feed rate; temperature of the drying agent at the inlet and outlet; pressure when the solution is fed into the drying chamber. It was found that in order to obtain a dry extract from the aboveground part of Scutellaria adenostegia, antihypoxic action, an aqueous extract obtained with water at a temperature of 60 ° C must be concentrated to a content of 15% of dry substances and dried in a spray dryer of the …

Quemando Leña En Guatemala: Salud, Sostenibilidad Y Costumbres, Sydney Underhill

World Languages and Cultures Senior Capstones

In the Central American country of Guatemala, firewood is an important fuel source. Eighty-eight percent of households in rural areas use wood stoves and open fires to cook and heat their homes. This tradition has fundamental roots in the culture and customs of Guatemala. Unfortunately, these methods contribute to air pollution. Consequently, it also results in smoke inhalation, which causes health problems. Additionally, the massive agriculture of other crops decreases the amount of firewood available to these households, affecting the sustainability of the resource. Some communities resist changing their use of firewood due to the profound nature that firewood holds …

Effects Of Leaf Species And Conditioning State Of Fresh Leaves On Colonization By Stream And Pond Macroinvertebrates, Austin R. Hoffman, Erika V. Iyengar

Pacific Faculty Work

Fresh, green leaves are increasing as resources in aquatic ecosystems due to more frequent severe spring and summer storms, but research on allochthonous resources typically uses senescent leaves. We examined macroinvertebrate colonization of green leaves of three native deciduous trees (red maple, red oak, and tulip poplar) over two weeks within both a stream and fishless pond. Leaf colonization varied depending on the taxa of leaves and colonizers, submersion time, and the ecosystem examined. Within the stream, the densities of isopods (Lirceus sp.) and snails (mostly the invasive Potamopyrgus antipodarum) did not vary significantly across leaf species. In contrast, mayflies …

First Record Of The Invasive Chenopodium Aphid, Hayhurstia Atriplicis (Linnaeus, 1761) (Hemiptera: Aphididae), In Colombia, Takumasa Kondo, Roberto Rosero, Jackeline Gaviria

Insecta Mundi

The chenopodium aphid, Hayhurstia atriplicis (Linnaeus, 1761) (Hemiptera: Aphididae), is reported for the first time in Colombia. The aphid was found on the aerial parts of the quinoa plant, Chenopodium quinoa Willd. (Amaranthaceae), especially on the leaves, in five municipalities in the department of Cauca, Colombia. Brief information on its natural enemies, distribution and biology is provided. This is the only aphid in Colombia known to cause malformations on the leaves of quinoa plants. In South America, this aphid has been found previously only in Ecuador, where it was reported for the first time in 2023 based on specimens collected …

Three Additions To The False Click Beetle (Coleoptera: Elateroidea: Eucnemidae) Fauna In The Nearctic Region, Robert L. Otto

Insecta Mundi

Three species of false click beetles (Coleoptera: Eucnemidae) are added to the Nearctic fauna. One new species, Isorhipis bicolor, is described from a small series collected in Florida, U.S.A. Eighteen specimens collected from Georgia were identified as Dyscharachthis amplicollis (Fleutiaux), new U.S.A. records for a species previously taken from Japan and Southeast Asia. Examination of a series of eucnemids collected by Kyle Schnepp in Florida allowed me to revisit the Deltometopus fauna in eastern North America. Antennal structures present in a series of male specimens in the loan and past examined specimens are definitive enough to resurrect Deltometopus …

First Record Of The Beekeeping Pest Aethina Tumida Murray (Coleoptera: Nitidulidae) For Honduras, Jesus Orozco

Insecta Mundi

Aethina tumida Murray (Coleoptera: Nitidulidae) (also known as the small hive beetle), an important pest in apiaries, is reported from Honduras for the first time, new country record. The precise distribution in the country is unknown, and no damage related to it has been observed. Photographs are provided to aid in its identification. Differentiation of A. tumida from Aethina villosa Reitter and Aethina quadrata Sharp, which also occur in Honduras, is provided.

ZooBank registration. urn:lsid:zoobank.org:pub:DAF12C6A-0F8C-4151-9C4D-F191CCC4032F

Identifying High-Value Tactical Livestock Decisions On A Mixed Enterprise Farm In A Variable Environment, Michael Young, John Young, Ross S. Kingwell, Philip E. Vercoe

Animal production and livestock research articles

Context

Australia is renowned for its climate variation, featuring years with drought and years with floods, which result in significant production and profit variability. Accordingly, to maximise profitability, dryland farming systems need to be dynamically managed in response to unfolding weather conditions.

Aims

The aim of this study is to identify and quantify optimal tactical livestock management for different weather-years.

Methods

This study employed a whole-farm optimisation model to analyse a representative mixed enterprise farm located in the Great Southern region of Western Australia. Using this model, we investigated the economic significance of five key livestock management tactics. These included …

Anticipatory Behaviors And Vocal Expression In A Group Of Captive African Elephants (Loxodonta Africana), Matthew B. Rios

Theses and Dissertations

Animal vocalizations convey motivational and affective properties. Using passive acoustic monitoring and behavioral observations, this study investigated the relationship between vocal communication and anticipatory behaviors within a group of captive African elephants (Loxodonta africana) to inquire whether bioacoustic monitoring has the potential to be used for assessing captive animal welfare.

A Study Of The Effects Of An Amino Acid Residue On The Thermal Stability Of A Collagen Triple Helix In Varied Sequence Context, Ph, And Ionic Strength Of The Buffer, Zhenxun Xu

Theses and Dissertations

Collagen mimetic peptides are used broadly for collagen research and biomedical applications. Unlike the synthetic peptides obtained by solid phase chemical synthesis, recombinant peptides have more than 100 amino acid residues in length and are expressed in E. coli using designed genes. These longer peptides can offer improved, more native-like functions of native collagen for biomedical applications. One major challenge is the intrinsically low stability of native collagen, which has a melting temperature just above the physiological temperature of the organism. To understand how to enhance the thermostability of the peptides, I investigated the effects of amino acid sequences on …

The Effects Of Limb Occlusion On The Slow Component Of V̇O2 During Intermittent, Heavy-Intensity Cycling, Sela Lomascolo

Honors Theses

This study examined the physiological responses to continuous, heavy-intensity (CONT), intermittent, heavy-intensity (INT), and intermittent, heavy-intensity cycling with limb occlusion (INT-LO). METHODS: Five young (23.2 ± 5.5 yrs.), healthy subjects participated in this study and completed a total of seven visits. Three conditions were completed by each subject: CONT, INT, and INT-LO. Each condition consisted of a 4-minute warm-up (20 W), 6 minutes of exercise, followed by 5 minutes of recovery cycling. For CONT, exercise was performed at Δ50% for the entire 6 minutes. INT and INT-LO alternated between 15 seconds of work at Δ50%, and then 3 seconds of …

The First Draft Genome Of Cold-Water Octocoral Anthothela Grandiflora, The Great Flowerbud Coral, Laurel Humphrey

Honors Scholar Theses

Cold-water corals are important sources of ocean biodiversity, yet populations are increasingly threatened by human activity and climate change. Soft octocorals may endure higher ocean acidification levels in comparison to stony hexacorals, although the mechanisms of octocoral biomineralization are less understood. Building genomic resources for cold-water octocorals could help to close information gaps by elucidating the evolutionary history of octocoral calcification and provide a reference for future studies of adaptation to acidified waters. This report describes the first reference genome for the cold-water octocoral species Anthothela grandiflora found throughout the Atlantic Ocean. Sequencing using Oxford Nanopore Technologies generated 43.6 Gb …

Genetic Variants For Head Size Share Genes And Pathways With Cancer, Aniket Mishra, Marie-Gabrielle Duperron, Xueqiu Jian, Isabel C Hostettler, Dianne H K Van Dam-Nolen, Sander Lamballais, Mikolaj A Pawlak, Cora E Lewis, Amaia Carrion-Castillo, Theo G M Van Erp, Céline S Reinbold, Jean Shin, Markus Scholz, Asta K Håberg, Anders Kämpe, Gloria H Y Li, Reut Avinun, Joshua R Atkins, Alyssa R Amod, Max Lam, Ami Tsuchida, Mariël W A Teunissen, Nil Aygün, Yash Patel, Dan Liang, Alexa S Beiser, Frauke Beyer, Joshua C Bis, Daniel Bos, R Nick Bryan, Robin Bülow, Svenja Caspers, Gwenaëlle Catheline, Charlotte A M Cecil, Shareefa Dalvie, Jean-François Dartigues, Charles Decarli, Maria Enlund-Cerullo, Judith M Ford, Barbara Franke, Barry I Freedman, Nele Friedrich, Melissa J Green, Simon Haworth, Catherine Helmer, Per Hoffmann, Georg Homuth, M Kamran Ikram, Clifford R Jack, Neda Jahanshad, Christiane Jockwitz, Yoichiro Kamatani, Annchen R Knodt, Shuo Li, Keane Lim, W T Longstreth, Fabio Macciardi, Outi Mäkitie, Bernard Mazoyer, Sarah E Medland, Susumu Miyamoto, Susanne Moebus, Thomas H Mosley, Ryan Muetzel, Thomas W Mühleisen, Manabu Nagata, Soichiro Nakahara, Nicholette D Palmer, Zdenka Pausova, Adrian Preda, Yann Quidé, William R Reay, Gennady V Roshchupkin, Reinhold Schmidt, Pamela J Schreiner, Kazuya Setoh, Chin Yang Shapland, Stephen Sidney, Beate St Pourcain, Jason L Stein, Yasuharu Tabara, Alexander Teumer, Anne Uhlmann, Aad Van Der Lugt, Meike W Vernooij, David J Werring, B Gwen Windham, A Veronica Witte, Katharina Wittfeld, Qiong Yang, Kazumichi Yoshida, Han G Brunner, Quentin Le Grand, Kang Sim, Dan J Stein, Donald W Bowden, Murray J Cairns, Ahmad R Hariri, Ching-Lung Cheung, Sture Andersson, Arno Villringer, Tomas Paus, Sven Cichon, Vince D Calhoun, Fabrice Crivello, Lenore J Launer, Tonya White, Peter J Koudstaal, Henry Houlden, Myriam Fornage, Fumihiko Matsuda, Hans J Grabe, M Arfan Ikram, Stéphanie Debette, Paul M Thompson, Sudha Seshadri, Hieab H H Adams

Faculty, Staff and Student Publications

The size of the human head is highly heritable, but genetic drivers of its variation within the general population remain unmapped. We perform a genome-wide association study on head size (N = 80,890) and identify 67 genetic loci, of which 50 are novel. Neuroimaging studies show that 17 variants affect specific brain areas, but most have widespread effects. Gene set enrichment is observed for various cancers and the p53, Wnt, and ErbB signaling pathways. Genes harboring lead variants are enriched for macrocephaly syndrome genes (37-fold) and high-fidelity cancer genes (9-fold), which is not seen for human height variants. Head size …

Understanding The Non-Canonical Regulation Of Srebp In Aspergillus Fumigatus, Muhammad Abubakar Khan

Dartmouth College Ph.D Dissertations

Aspergillus fumigatus is an opportunistic fungal pathogen causing invasive pulmonary aspergillosis (IPA), with high mortality rates in immunocompromised individuals. Adaptation to the hypoxic microenvironment of IPA is crucial for fungal virulence. The transcription factor SrbA, a Sterol Regulatory Element-Binding Protein (SREBP) homolog, plays a key role in this hypoxic response and regulates genes involved in hypoxic growth, sterol biosynthesis, and azole resistance, making it an attractive therapeutic target.

However, SrbA activation in A. fumigatus lacks critical components of the canonical SREBP pathway, such as SCAP, Site-1 protease (S1P), and Site-2 protease (S2P). Instead, the rhomboid protease RbdB, signal peptide peptidase …

Assessing The Effects Of Cold Storage Regimes Of North American Bombus Gynes, Thuy Tien T. Lindsay, Marcia M. Hagen, Joyce N. Knoblett, Joseph P. Rinehart, Karen M. Kapheim, James P. Strange

Biology Faculty Publications

Bumble bees are the primary commercial pollinators for greenhouse-grown crops and managing them requires insight into the Bombus life cycle. However, some aspects of the life cycle are not fully understood. Once mated, adult Bombus gynes can be stored for a short term at a constant low temperature (CLT). However, survival rates for some species are low during CLT, particularly when storage periods exceed a month. To address this, we tested the hypothesis that Bombus gynes stored in a fluctuating thermal regime (FTR) have increased survival compared to gynes stored in CLT. Specifically, the FTR had a baseline temperature of …

Dual Modes Of Dopamine Underly Distinct Facets Of Impulsive Actions, Tzvia Pinkhasov

Arts & Sciences Graduate Student Theses and Dissertations

During the pursuit of basic needs, animals sometimes fail to suppress actions that are maladaptive and counterproductive to their survival. In humans, these actions are often called impulsive because they can incur negative consequences. Impulsivity is ubiquitous across psychiatric disorders and related to debilitating outcomes such as substance abuse, crime and suicidality. Despite its risks, a lack of a neural mechanism understanding of impulsive actions impedes the development of effective treatments.In this dissertation, I set out to bridge the knowledge gained from the parallel fields of neuropsychopharmacology, experimental psychology, and systems neuroscience to uncover neural mechanisms of impulsive actions. Clinicians …

Integrating Dna Methylation And 3d-Genome Architecture To Identify Functional Regulatory Sequences In Idh-Mutant Aml, Elisabeth Wilson

Arts & Sciences Graduate Student Theses and Dissertations

Acute myeloid leukemia (AML) is a genetically and phenotypically heterogeneous disease. Recurrent mutations in genes involved in epigenetic pathways are common in AML and are thought to contribute to this variability by disrupting epigenetic patterns relative to normal hematopoietic cells. The most well-studied epigenetic modification in AML is DNA methylation. Although methods for studying DNA methylation have improved significantly in the past decade, the landscape of methylation changes in AML and how they relate to chromatin architecture and gene regulation is still not fully understood. This thesis is focused on the DNA methylation phenotype of IDH1 or IDH2 mutations in …

Neuroepigenetic Mechanisms Of Brain Development: From Technology To Biological Insights, Allen Yen

Arts & Sciences Graduate Student Theses and Dissertations

Each cell in the brain has the same genomic sequence, yet they can have vastly different phenotypes and function. This diversity is a result of complex genetic and signaling pathways, and knowing how these are regulated is key to understanding physiological development and how pathogenic dysfunctions arise. Genomic methods such as chromatin immunoprecipitation followed by sequencing (ChIP-seq) and assay for transposase-accessible chromatin with sequencing (ATAC-seq) have played pivotal roles in dissecting these processes. However, a key limitation is that the cells are destroyed upon observation of their molecular states, which preclude our ability to correlate historical epigenetic information with future …

Treatment Outcomes In Patients With Metastatic Renal Cell Carcinoma With Sarcomatoid And/Or Rhabdoid Dedifferentiation After Progression On Immune Checkpoint Therapy, Andrew W Hahn, Devaki Shilpa Surasi, Paul V Viscuse, Tharakeswara K Bathala, Andrew J Wiele, Amado J Zurita, Eric Jonasch, Jianjun Gao, Sangeeta Goswami, Omar Alhalabi, Priya Rao, Kanishka Sircar, Nizar M Tannir, Pavlos Msaouel

Faculty, Staff and Student Publications

BACKGROUND: Metastatic RCC with sarcomatoid and/or rhabdoid (S/R) dedifferentiation is an aggressive disease associated with improved response to immune checkpoint therapy (ICT). The outcomes of patients treated with VEGFR-targeted therapies (TT) following ICT progression have not been investigated.

PATIENTS AND METHODS: Retrospective review of 57 patients with sarcomatoid (S), rhabdoid (R), or sarcomatoid plus rhabdoid (S + R) dedifferentiation who received any TT after progression on ICT at an academic cancer center. Clinical endpoints of interest included time on TT, overall survival (OS) from initiation of TT, and objective response rate (ORR) by RECIST version 1.1. Multivariable models adjusted for …

Evaluating The Heterogeneity Of Hippocampal Avoidant Whole Brain Radiotherapy Treatment Effect: A Secondary Analysis Of Nrg Cc001, Hua-Ren R Cherng, Kai Sun, Søren Bentzen, Terri S Armstrong, Vinai Gondi, Minesh Mehta

Faculty, Staff and Student Publications

Background: Hippocampal avoidant whole brain radiotherapy (HA-WBRT) is the standard of care for patients needing WBRT for brain metastases. This study, using existing data from NRG Oncology CC001 including baseline tumor characteristics and patient-reported MD Anderson Symptom Inventory-Brain Tumor (MDASI-BT) scores, sought to identify subgroups of patients that demonstrate differential neuroprotective treatment response to HA-WBRT.

Methods: An exploratory analysis of NRG CC001, a phase 3 trial in which 518 patients were randomly assigned to WBRT plus memantine or HA-WBRT plus memantine, was performed. Rates of neurocognitive function failure (NCFF) were estimated between subgroups and stratified by arm. Covariate and subgroup …

A Comprehensive Approach To Evaluate Genetic Abnormalities In Multiple Myeloma Using Optical Genome Mapping, Ying S Zou, Melanie Klausner, Jen Ghabrial, Victoria Stinnett, Patty Long, Jaclyn B Murry, Christopher D Gocke, Rena R Xian, Kevin H Toomer, Jing Christine Ye, Robert Z Orlowski, Carol Ann Huff, Syed Abbas Ali, Philip H Imus, Christian B Gocke, Guilin Tang

Faculty, Staff and Student Publications

No abstract provided.

Focal Adhesion Kinase-Yap Signaling Axis Drives Drug-Tolerant Persister Cells And Residual Disease In Lung Cancer, Franziska Haderk, Yu-Ting Chou, Lauren Cech, Celia Fernández-Méndez, Johnny Yu, Ismail M Meraz, D Lucas Kerr, Carlos Gomez, David V Allegakoen, Juan Guan, Khyati N Shah, Kari A Herrington, Oghenekevwe M Gbenedio, Shigeki Nanjo, Mourad Majidi, Whitney Tamaki, Yashar K Pourmoghadam, Julia K Rotow, Caroline E Mccoach, Jonathan W Riess, J Silvio Gutkind, Tracy T Tang, Leonard Post, Bo Huang, Pilar Santisteban, Hani Goodarzi, Sourav Bandyopadhyay, Calvin J Kuo, Jeroen P Roose, Wei Wu, Collin M Blakely, Jack A Roth, Trever G Bivona

Faculty, Staff and Student Publications

Targeted therapy is effective in many tumor types including lung cancer, the leading cause of cancer mortality. Paradigm defining examples are targeted therapies directed against non-small cell lung cancer (NSCLC) subtypes with oncogenic alterations in EGFR, ALK and KRAS. The success of targeted therapy is limited by drug-tolerant persister cells (DTPs) which withstand and adapt to treatment and comprise the residual disease state that is typical during treatment with clinical targeted therapies. Here, we integrate studies in patient-derived and immunocompetent lung cancer models and clinical specimens obtained from patients on targeted therapy to uncover a focal adhesion kinase (FAK)-YAP signaling …

Triggering Receptor Expressed On Myeloid Cells 2 (Trem2) Regulates Phagocytosis In Glioblastoma, Mekenzie M Peshoff, Pravesh Gupta, Shivangi Oberai, Rakesh Trivedi, Hiroshi Katayama, Minghao Dang, Joy Gumin, Divya B Kadri, Jessica K Lin, Nancy K Milam, Mark E Maynard, Brian D Vaillant, Brittany Parker-Kerrigan, Frederick F Lang, Jason T Huse, Antonio Iavarone, Linghua Wang, Karen Clise-Dwyer, Krishna P Bhat

Faculty, Staff and Student Publications

Background: Glioblastomas (GBMs) are central nervous system tumors that resist standard-of-care interventions and even immune checkpoint blockade. Myeloid cells in the tumor microenvironment can contribute to GBM progression; therefore, emerging immunotherapeutic approaches include reprogramming these cells to achieve desirable antitumor activity. Triggering receptor expressed on myeloid cells 2 (TREM2) is a myeloid signaling regulator that has been implicated in a variety of cancers and neurological diseases with contrasting functions, but its role in GBM immunopathology and progression is still under investigation.

Methods: Our reverse translational investigations leveraged single-cell RNA sequencing and cytometry of human gliomas to characterize TREM2 expression across …

New Records Of Mesobuthus Rakhshanii Barahoei, 2022 In Iran (Scorpiones: Buthidae), Ersen A. Yağmur, Zhale Baghernavesi, Zahra Taherkhani, Parsa Akbari, Mohammad Moradi

Euscorpius

Mesobuthus rakhshanii Barahoei, 2022 (Scorpiones: Buthidae) was so far known only from the type locality in Sistan and Baluchestan Province, Iran. We give a list of numerous new records of this species from the same province. A map and detailed illustrations are provided.