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Articles 25831 - 25860 of 255935

Full-Text Articles in Life Sciences

Development Of A Food Composition Database For The Estimation Of Dietary S-Methyl Cysteine Sulfoxide From Vegetables, Caroline R. Hill, Emma L. Connolly, Armaghan Shafaei, Lois Balmer, Liezhou Zhong, Taulant Muka, Antonietta Hayhoe, Shikha Saha, Richard J. Woodman, Joshua R. Lewis, Jonathan M. Hodgson, Lauren C. Blekkenhorst Jun 2024

Development Of A Food Composition Database For The Estimation Of Dietary S-Methyl Cysteine Sulfoxide From Vegetables, Caroline R. Hill, Emma L. Connolly, Armaghan Shafaei, Lois Balmer, Liezhou Zhong, Taulant Muka, Antonietta Hayhoe, Shikha Saha, Richard J. Woodman, Joshua R. Lewis, Jonathan M. Hodgson, Lauren C. Blekkenhorst

Research outputs 2022 to 2026

A food composition database estimating S-methyl cysteine sulfoxide (SMCSO) was created following a systematic literature search. SMCSO data (705 entries) from 19 vegetables were summarised: brassicas (n = 10) and alliums (n = 9). The highest SMCSO in brassicas was reported in Brussels sprouts (median [range]: 318 [68−420] mg/100 g fresh weight (FW)) whilst the lowest was in radish (19 [4–45] mg/100 g FW). Brussels sprouts were almost twice as concentrated in SMCSO as cauliflower, followed by cabbage, kale, broccoli, kohlrabi, swede, Chinese cabbage, and turnips. The alliums highest in SMCSO were Chinese chives (271 [185−413] mg/100 g FW) followed …


Synthesis Of Dyes Sulfamidazole: Characterization, Evaluation, Molecular Docking And Global Descriptors By Density Functional Theory (Dft)., Athra G. Sager, Jawad Kadhim Abaies, Zeena R. Katoof May 2024

Synthesis Of Dyes Sulfamidazole: Characterization, Evaluation, Molecular Docking And Global Descriptors By Density Functional Theory (Dft)., Athra G. Sager, Jawad Kadhim Abaies, Zeena R. Katoof

Karbala International Journal of Modern Science

In the present work, novel azo compounds of sulfamidazole were created via the reaction of diazonium salt of sulfamidazole with several aromatic molecules including (resorcinol, 2-nitro phenol, 3-nitro phenol, and 4-nitro phenol)) (Z1–Z4). The new compounds (Z1-Z4) were identified using FTIR, 1HNMR techniques, in addition to melting point measurements. The biological activity of compounds (Z1-Z4) was studied against four kinds of bacteria including E. coli, Klebsiella pneumonia, Salmonella, and Staphylococcus aureus. The findings showed that all compounds (Z1-Z4) were active against the examined bacteria. Theoretical studies of the antibacterial ability of the prepared compound against DNA gyrase enzyme …


Agent-Based Modeling For The Neophyte: An Application Of Netlogo, Olcay Akman, Siddharth Bhumpelli, Christopher Hay-Jahans May 2024

Agent-Based Modeling For The Neophyte: An Application Of Netlogo, Olcay Akman, Siddharth Bhumpelli, Christopher Hay-Jahans

Spora: A Journal of Biomathematics

Agent-based modeling has found applications in a wide range of fields including economics, sociology, ecology, epidemiology, transportation planning, and more. Its versatility allows researchers to investigate various “what-if” scenarios, test the effects of different policies or interventions, and gain insights into the underlying mechanisms driving complex systems. This article is intended for the curious student or researcher who is unfamiliar with agent based modeling, and is looking for a quick but reasonably informative exposure to the field.


A New Species Of Paranthrene Hübner (Lepidoptera: Sesiidae) From The Northern Midwest United States, William H. Smith Iii, William H. Taft Jr., Anthony I. Cognato May 2024

A New Species Of Paranthrene Hübner (Lepidoptera: Sesiidae) From The Northern Midwest United States, William H. Smith Iii, William H. Taft Jr., Anthony I. Cognato

Insecta Mundi

A clearwing moth species, Paranthrene sogaardi Taft and Smith, 2024, new species, is described from Michigan and Minnesota. The recognition of this new species is based on a phylogeny estimated from mitochondrial cytochrome oxidase I and wingless DNA sequences of 25 specimens representing all Paranthrene Hübner species including individuals from various locations. Paranthrene sogaardi new species was monophyletic and differed from Paranthrene tabaniformis Rottenburg, 1775 by a mean of 7.6% COI pairwise “p” distance, coloration, and genitalic morphology.

ZooBank registration. urn:lsid:zoobank.org:pub:8B9ED6CE-4DEB-4CB2-9235-3CA593F4D9DB


Corrections And Additions To The Hydnocerina (Coleoptera: Cleridae: Clerinae: Hydnocerini) Of Mexico, John M. Leavengood Jr. May 2024

Corrections And Additions To The Hydnocerina (Coleoptera: Cleridae: Clerinae: Hydnocerini) Of Mexico, John M. Leavengood Jr.

Insecta Mundi

Corrections, additions and remarks are made with respect to the recent checklist of the Cleridae (Coleoptera) of Mexico (Araujo-Castillo et al. 2024). Current valid names, synonymies, clarifications of taxonomic problems, and omitted taxa are reviewed. This work is intended to serve as a supplement to the “Hydnocerinae” section of the checklist.

ZooBank registration. urn:lsid:zoobank.org:pub:EF3E45B5-6EA6-41AB-B92F-DB4ABF9D8215


Taxonomic Notes On Velvet Ants Of The Genus Timulla Ashmead, 1899 (Hymenoptera: Mutillidae) In The United States Of America And Canada, George C. Waldren May 2024

Taxonomic Notes On Velvet Ants Of The Genus Timulla Ashmead, 1899 (Hymenoptera: Mutillidae) In The United States Of America And Canada, George C. Waldren

Insecta Mundi

The exclusively New World velvet ant genus Timulla Ashmead, 1899 (Hymenoptera: Mutillidae: Mutillinae: Trogaspidiini) contains 180 species and ten subspecies. Most of these species are known from a single sex, and the validity of the subspecies has not been evaluated since their original description in 1937 and 1938. The Timulla fauna of the United States of America includes thirty species and eight subspecies, and the fauna of Canada includes three species. The faunas of these two countries were critically studied with the following results. Out of the eight total subspecies, seven were found to be structurally identical to and sympatric …


Internet-Based Data Platforms Re-Define The Distributions Of Some Large Crabronid Wasps In Arkansas (Hymenoptera: Crabronidae), David E. Bowles May 2024

Internet-Based Data Platforms Re-Define The Distributions Of Some Large Crabronid Wasps In Arkansas (Hymenoptera: Crabronidae), David E. Bowles

Insecta Mundi

The geographic distributions of three large wasps, Sphecius speciosus (Drury), Stictia carolina Fabricius, and Stizus brevipennis Walsh (Hymenoptera: Crabronidae), occurring in Arkansas are defined using museum specimens and three internet-based data platforms. The internet-based data platforms generally provided more county location records than museum records. Using data from internet sources for easily identified species can better serve to illustrate the known distributions for some species thus making for a powerful tool elucidating distributional patterns and conservation planning.

ZooBank registration. urn:lsid:zoobank.org:pub:DCAE9192-1765-40CD-952B-0A094F413991


Production, Utilization And Quality Of Irrigated Grasses And Legumes In The Mountain West Usa Under Mob Stocking Or Clipping, Jennifer W. Macadam, Brody Maughan, Xin Dai May 2024

Production, Utilization And Quality Of Irrigated Grasses And Legumes In The Mountain West Usa Under Mob Stocking Or Clipping, Jennifer W. Macadam, Brody Maughan, Xin Dai

Browse all Datasets

Feed is the most costly input for US ruminant livestock production systems, and increasing the utilization efficiency of irrigated forage systems can improve system profitability. This study assessed the production, utilization and quality of 22 intensively managed perennial grasses and legumes. Forages were cultivated as monocultures under irrigation and subjected to similarly intense clipping or mob stocking for two years at six-week intervals between May and September. Grasses and legumes were randomly assigned to 22 adjacent 1.5-m-wide by 9-m-long subplots within each whole plot, and pairs of whole plots were randomly assigned to grazing or clipping management. Seven grasses did …


Church2024_Development Of A Rhizobium Seed Coating...Data, Bridget M. Church, Brad Geary, Curtis L. Drake, Joel Griffitts, Kate Ruebelmann, Shannon V. Nelson, Matthew D. Madsen May 2024

Church2024_Development Of A Rhizobium Seed Coating...Data, Bridget M. Church, Brad Geary, Curtis L. Drake, Joel Griffitts, Kate Ruebelmann, Shannon V. Nelson, Matthew D. Madsen

ScholarsArchive Data

This file contains the data description for the “Church2024_Development of a Rhizobium Seed Coating…” Supplementary File.

The excel file contains six worksheets: 1) Exceed Study Data, 2) Exceed Study Tiss TotN%, 3) Inoc Study data, 4) Inoc Study Tiss TotN%, 5) Seed Coat study data, Seed Coat study Tiss TotN%.


Plas 439: Organic Farming And Food Systems Faculty-Led Inquiry Into Reflective Scholarly Teaching Benchmark Portfolio, Christian Stephenson May 2024

Plas 439: Organic Farming And Food Systems Faculty-Led Inquiry Into Reflective Scholarly Teaching Benchmark Portfolio, Christian Stephenson

UNL Faculty Course Portfolios

Organic Farming and Food Systems is a senior and graduate level course for students in the Department of Agronomy and Horticulture. This course was previously offered but has been significantly modified as I have taken on responsibility for the course. Goals for the course include student comprehension of the methods of organic and regenerative farming and the impacts of those methods on economic, environmental, and social sustainability. An additional goal is to build student competency in the evaluation of primary, secondary, and tertiary information resources and critical thinking surrounding issues in food production. Assessment for the course was through diverse …


Diet Quality And Resilience Through Adulthood: A Cross-Sectional Analysis Of The Well For Life Study, Sparkle Springfield-Trice, Cara Joyce, Yi-Hsuan Wu, Ann W. Hsing, Kristen Cunanan, Christopher Gardner May 2024

Diet Quality And Resilience Through Adulthood: A Cross-Sectional Analysis Of The Well For Life Study, Sparkle Springfield-Trice, Cara Joyce, Yi-Hsuan Wu, Ann W. Hsing, Kristen Cunanan, Christopher Gardner

Biostatistics Collaborative Core: Faculty Publications and Other Works

Despite evidence suggesting the importance of psychological resilience for successful aging, little is known about the relationship between diet quality and resilience at different ages. Our study aims to examine the association between diet quality and resilience across the stages of adulthood. Using Stanfords’ WELL for Life (WELL) survey data, we conducted a cross-sectional study of diet quality, resilience, sociodemographic, perceived stress, lifestyle, and mental health factors among 6171 Bay Area adults. Diet quality was measured by the WELL Diet Score, which ranges from 0–120. A higher score indicates a better diet quality. Linear regression analysis was used to evaluate …


Correction: Ver-Net: A Hybrid Transfer Learning Model For Lung Cancer Detection Using Ct Scan Images, Saurav Mallik, Zhongming Zhao May 2024

Correction: Ver-Net: A Hybrid Transfer Learning Model For Lung Cancer Detection Using Ct Scan Images, Saurav Mallik, Zhongming Zhao

Faculty, Staff and Student Publications

No abstract provided.


Long Time No See: New Reports Of Legua Rosea Amédégnato And Poulain, 1986 (Orthoptera: Caelifera: Romaleidae: Romaleinae: Leguini), A Rare Arboreal Grasshopper From Brazil, Daniela Santos Martins Silva, Renan Da Silva Olivier, Larissa Lima De Queiroz, Marcelo Ribeiro Pereira, Jardel Boscardin, Guilherme Rabelo D’Angelis May 2024

Long Time No See: New Reports Of Legua Rosea Amédégnato And Poulain, 1986 (Orthoptera: Caelifera: Romaleidae: Romaleinae: Leguini), A Rare Arboreal Grasshopper From Brazil, Daniela Santos Martins Silva, Renan Da Silva Olivier, Larissa Lima De Queiroz, Marcelo Ribeiro Pereira, Jardel Boscardin, Guilherme Rabelo D’Angelis

Insecta Mundi

The genus Legua Walker, 1870 comprises only two known species from Central America and Brazil, with a notable scarcity of collected specimens. Herein, we provide a new contribution to our knowledge of the distribution of Legua rosea Amédégnato and Poulain, 1986 (Romaleinae: Leguini), that has a restricted distribution in Brazil, based on entomological collection data and social media information. Our records emphasize the importance of natural history collections and new tools for biodiversity studies.

ZooBank registration. urn:lsid:zoobank.org:pub:17E0802B-A389-4983-AC74-21B51197F557


Morphometric Analysis And Taxonomic Re-Evaluation Of Pepsis Cerberus Lucas And P. Elegans Lepeletier (Hymenoptera: Pompilidae: Pepsinae: Pepsini), Frank E. Kurczewski, Akira Shimizu, Diane H. Kiernan May 2024

Morphometric Analysis And Taxonomic Re-Evaluation Of Pepsis Cerberus Lucas And P. Elegans Lepeletier (Hymenoptera: Pompilidae: Pepsinae: Pepsini), Frank E. Kurczewski, Akira Shimizu, Diane H. Kiernan

Insecta Mundi

Hurd (1952) separated Pepsis cerberus Lucas from P. elegans Lepeletier (Hymenoptera: Pompilidae: Pepsinae: Pepsini) based on external morphology and biogeography. Vardy (2005) synonymized the familiar and historically well-documented P. cerberus and P. elegans, combining these Nearctic taxa with several Neotropical variants in an extremely broad definition of P. menechma Lepeletier. In doing so, Vardy (2005) breached the principle of nomenclatural stability. He ignored the prevailing usage and clearly violated articles 23.2, 23.3 and 23.9.1.2 of the ICZN (1999). Morphological differences, ecological divergence, and narrow sympatric geographic distribution of P. cerberus and P. elegans …


Dynamic Responses Of Blood Metabolites To Nutrient Depletion And Repletion In Broiler Chicken Nutrition, A.J. Cowieson, C. A. Phillips, Garrett J. Mullenix, E. S. Greene, E. Papadopoulou, Sami Dridi May 2024

Dynamic Responses Of Blood Metabolites To Nutrient Depletion And Repletion In Broiler Chicken Nutrition, A.J. Cowieson, C. A. Phillips, Garrett J. Mullenix, E. S. Greene, E. Papadopoulou, Sami Dridi

Poultry Science Faculty Publications and Presentations

A total of 720 male Cobb 500 broiler chicks were used in a 5 treatment and 8 replicate experiment to explore dynamic changes in blood metabolites in response to short-term nutrient depletion and repletion. Day old chicks were offered a corn and soybean meal-based common starter diet from d1 to 14 that was formulated to meet all nutrient requirements of the birds. From d15 to 17, the experimental diets were offered, before returning all groups to a common diet from d18 to 20, at which point the experiment was terminated. A total of 5 experimental diets were designed. A …


Nivolumab Plus Relatlimab In Patients With Previously Treated Microsatellite Instability-High/Mismatch Repair-Deficient Metastatic Colorectal Cancer: The Phase Ii Checkmate 142 Study, Michael J Overman, Fabio Gelsomino, Massimo Aglietta, Mark Wong, Maria Luisa Limon Miron, Pilar García-Alfonso, Antonio Cubillo Gracian, Eric Van Cutsem, Bassel El-Rayes, Stephen M Mccraith, Beilei He, Ming Lei, Sara Lonardi May 2024

Nivolumab Plus Relatlimab In Patients With Previously Treated Microsatellite Instability-High/Mismatch Repair-Deficient Metastatic Colorectal Cancer: The Phase Ii Checkmate 142 Study, Michael J Overman, Fabio Gelsomino, Massimo Aglietta, Mark Wong, Maria Luisa Limon Miron, Pilar García-Alfonso, Antonio Cubillo Gracian, Eric Van Cutsem, Bassel El-Rayes, Stephen M Mccraith, Beilei He, Ming Lei, Sara Lonardi

Faculty, Staff and Student Publications

BACKGROUND: Programmed death-1 (PD-1) inhibitors, including nivolumab, have demonstrated long-term survival benefit in previously treated patients with microsatellite instability-high/mismatch repair-deficient (MSI-H/dMMR) metastatic colorectal cancer (CRC). PD-1 and lymphocyte-activation gene 3 (LAG-3) are distinct immune checkpoints that are often co-expressed on tumor-infiltrating lymphocytes and contribute to tumor-mediated T-cell dysfunction. Relatlimab is a LAG-3 inhibitor that has demonstrated efficacy in combination with nivolumab in patients with melanoma. Here, we present the results from patients with MSI-H/dMMR metastatic CRC treated with nivolumab plus relatlimab in the CheckMate 142 study.

METHODS: In this open-label, phase II study, previously treated patients with MSI-H/dMMR metastatic CRC …


Using Patient-Specific 3d Modeling And Simulations To Optimize Microwave Ablation Therapy For Liver Cancer, Amirreza Heshmat, Caleb S O'Connor, Jessica Albuquerque Marques Silva, Iwan Paolucci, Aaron Kyle Jones, Kristy K Brock May 2024

Using Patient-Specific 3d Modeling And Simulations To Optimize Microwave Ablation Therapy For Liver Cancer, Amirreza Heshmat, Caleb S O'Connor, Jessica Albuquerque Marques Silva, Iwan Paolucci, Aaron Kyle Jones, Kristy K Brock

Faculty, Staff and Student Publications

Microwave ablation (MWA) of liver tumors presents challenges like under- and over-ablation, potentially leading to inadequate tumor destruction and damage to healthy tissue. This study aims to develop personalized three-dimensional (3D) models to simulate MWA for liver tumors, incorporating patient-specific characteristics. The primary objective is to validate the predicted ablation zones compared to clinical outcomes, offering insights into MWA before therapy to facilitate accurate treatment planning. Contrast-enhanced CT images from three patients were used to create 3D models. The simulations used coupled electromagnetic wave propagation and bioheat transfer to estimate the temperature distribution, predicting tumor destruction and ablation margins. The …


The Kat Module Of The Saga Complex Maintains The Oncogenic Gene Expression Program In Mycn- Amplified Neuroblastoma, Clare F Malone, Nathaniel W Mabe, Alexandra B Forman, Gabriela Alexe, Kathleen L Engel, Melinda Soeung, Allen Basanthakumar, Bin Liu, Sharon Y R Dent, Kimberly Stegmaier May 2024

The Kat Module Of The Saga Complex Maintains The Oncogenic Gene Expression Program In Mycn- Amplified Neuroblastoma, Clare F Malone, Nathaniel W Mabe, Alexandra B Forman, Gabriela Alexe, Kathleen L Engel, Melinda Soeung, Allen Basanthakumar, Bin Liu, Sharon Y R Dent, Kimberly Stegmaier

Faculty, Staff and Student Publications

Pediatric cancers are frequently driven by genomic alterations that result in aberrant transcription factor activity. Here, we used functional genomic screens to identify multiple genes within the transcriptional coactivator Spt-Ada-Gcn5-acetyltransferase (SAGA) complex as selective dependencies for MYCN-amplified neuroblastoma, a disease of dysregulated development driven by an aberrant oncogenic transcriptional program. We characterized the DNA recruitment sites of the SAGA complex in neuroblastoma and the consequences of loss of SAGA complex lysine acetyltransferase (KAT) activity on histone acetylation and gene expression. We demonstrate that loss of SAGA complex KAT activity is associated with reduced MYCN binding on chromatin, suppression of …


Vaccine Uptake And Intentions: Insights From A Texas Survey On Factors Influencing Covid-19 Vaccination Decisions, Yordanos M Tiruneh, Paula M Cuccaro, Kimberly S Elliott, Jing Xie, Journey Martinez, Christian R Alvarado May 2024

Vaccine Uptake And Intentions: Insights From A Texas Survey On Factors Influencing Covid-19 Vaccination Decisions, Yordanos M Tiruneh, Paula M Cuccaro, Kimberly S Elliott, Jing Xie, Journey Martinez, Christian R Alvarado

Faculty, Staff and Student Publications

The effectiveness of COVID-19 vaccines depends on widespread vaccine uptake. Employing a telephone-administered weighted survey with 19,502 participants, we examined the determinants of COVID-19 vaccine acceptance among adults in Texas. We used multiple regression analysis with LASSO-selected variables to identify factors associated with COVID-19 vaccine uptake and intentions to receive the vaccine among the unvaccinated. The prevalence of unvaccinated individuals (22%) was higher among those aged 18-39, males, White respondents, English speakers, uninsured individuals, those facing financial challenges, and individuals expressing no concern about contracting the illness. In a fully adjusted regression model, higher odds of being unvaccinated were observed …


Prediction Accuracy Of Soil Chemical Parameters By Field- And Laboratory-Obtained Vis-Nir Spectra After External Parameter Orthogonalization, Konrad Metzger, Frank Liebisch, Juan M Herrera, Thomas Guillaume, Luca Bragazza May 2024

Prediction Accuracy Of Soil Chemical Parameters By Field- And Laboratory-Obtained Vis-Nir Spectra After External Parameter Orthogonalization, Konrad Metzger, Frank Liebisch, Juan M Herrera, Thomas Guillaume, Luca Bragazza

Faculty, Staff and Student Publications

One challenge in predicting soil parameters using in situ visible and near infrared spectroscopy is the distortion of the spectra due to soil moisture. External parameter orthogonalization (EPO) is a mathematical method to remove unwanted variability from spectra. We created two different EPO correction matrices based on the difference between spectra collected in situ and, respectively, spectra collected from the same soil samples after drying and sieving and after drying, sieving and finely grinding. Spectra from 134 soil samples recorded with two different spectrometers were split into calibration and validation sets and the two EPO corrections were applied. Clay, organic …


Two Genome-Wide Interaction Loci Modify The Association Of Nonsteroidal Anti-Inflammatory Drugs With Colorectal Cancer, David A Drew, Andre E Kim, Yi Lin, Conghui Qu, John Morrison, Eric Kawaguchi, Yubo Fu, Natalia Zemlianskaia, Virginia Díez-Obrero, Stephanie A Bien, Niki Dimou, Demetrius Albanes, James W Baurley, Anna H Wu, Daniel D Buchanan, John D Potter, Ross L Prentice, Sophia Harlid, Volker Arndt, Elizabeth L Barry, Sonja I Berndt, Emmanouil Bouras, Hermann Brenner, Arif Budiarto, Andrea Burnett-Hartman, Peter T Campbell, Robert Carreras-Torres, Graham Casey, Jenny Chang-Claude, David V Conti, Matthew A M Devall, Jane C Figueiredo, Stephen B Gruber, Andrea Gsur, Marc J Gunter, Tabitha A Harrison, Akihisa Hidaka, Michael Hoffmeister, Jeroen R Huyghe, Mark A Jenkins, Kristina M Jordahl, Anshul Kundaje, Loic Le Marchand, Li Li, Brigid M Lynch, Neil Murphy, Rami Nassir, Polly A Newcomb, Christina C Newton, Mireia Obón-Santacana, Shuji Ogino, Jennifer Ose, Rish K Pai, Julie R Palmer, Nikos Papadimitriou, Bens Pardamean, Andrew J Pellatt, Anita R Peoples, Elizabeth A Platz, Gad Rennert, Edward Ruiz-Narvaez, Lori C Sakoda, Peter C Scacheri, Stephanie L Schmit, Robert E Schoen, Mariana C Stern, Yu-Ru Su, Duncan C Thomas, Yu Tian, Konstantinos K Tsilidis, Cornelia M Ulrich, Caroline Y Um, Fränzel J B Van Duijnhoven, Bethany Van Guelpen, Emily White, Li Hsu, Victor Moreno, Ulrike Peters, Andrew T Chan, W James Gauderman May 2024

Two Genome-Wide Interaction Loci Modify The Association Of Nonsteroidal Anti-Inflammatory Drugs With Colorectal Cancer, David A Drew, Andre E Kim, Yi Lin, Conghui Qu, John Morrison, Eric Kawaguchi, Yubo Fu, Natalia Zemlianskaia, Virginia Díez-Obrero, Stephanie A Bien, Niki Dimou, Demetrius Albanes, James W Baurley, Anna H Wu, Daniel D Buchanan, John D Potter, Ross L Prentice, Sophia Harlid, Volker Arndt, Elizabeth L Barry, Sonja I Berndt, Emmanouil Bouras, Hermann Brenner, Arif Budiarto, Andrea Burnett-Hartman, Peter T Campbell, Robert Carreras-Torres, Graham Casey, Jenny Chang-Claude, David V Conti, Matthew A M Devall, Jane C Figueiredo, Stephen B Gruber, Andrea Gsur, Marc J Gunter, Tabitha A Harrison, Akihisa Hidaka, Michael Hoffmeister, Jeroen R Huyghe, Mark A Jenkins, Kristina M Jordahl, Anshul Kundaje, Loic Le Marchand, Li Li, Brigid M Lynch, Neil Murphy, Rami Nassir, Polly A Newcomb, Christina C Newton, Mireia Obón-Santacana, Shuji Ogino, Jennifer Ose, Rish K Pai, Julie R Palmer, Nikos Papadimitriou, Bens Pardamean, Andrew J Pellatt, Anita R Peoples, Elizabeth A Platz, Gad Rennert, Edward Ruiz-Narvaez, Lori C Sakoda, Peter C Scacheri, Stephanie L Schmit, Robert E Schoen, Mariana C Stern, Yu-Ru Su, Duncan C Thomas, Yu Tian, Konstantinos K Tsilidis, Cornelia M Ulrich, Caroline Y Um, Fränzel J B Van Duijnhoven, Bethany Van Guelpen, Emily White, Li Hsu, Victor Moreno, Ulrike Peters, Andrew T Chan, W James Gauderman

Faculty, Staff and Student Publications

Regular, long-term aspirin use may act synergistically with genetic variants, particularly those in mechanistically relevant pathways, to confer a protective effect on colorectal cancer (CRC) risk. We leveraged pooled data from 52 clinical trial, cohort, and case-control studies that included 30,806 CRC cases and 41,861 controls of European ancestry to conduct a genome-wide interaction scan between regular aspirin/nonsteroidal anti-inflammatory drug (NSAID) use and imputed genetic variants. After adjusting for multiple comparisons, we identified statistically significant interactions between regular aspirin/NSAID use and variants in 6q24.1 (top hit


Comparative Analysis Of Doxycycline And Ayurvedic Herbs To Target Metastatic Breast Cancer: An In-Silico Approach, Acharya Balkrishna, Rashmi Mittal, Rohan Malik, Hariom Verma, Kuldeep Singh Mehra, Hariom Chaturvedi, Okeshwar Okeshwar, Swami Ishdev, Ajay Kumar, Vedpriya Arya May 2024

Comparative Analysis Of Doxycycline And Ayurvedic Herbs To Target Metastatic Breast Cancer: An In-Silico Approach, Acharya Balkrishna, Rashmi Mittal, Rohan Malik, Hariom Verma, Kuldeep Singh Mehra, Hariom Chaturvedi, Okeshwar Okeshwar, Swami Ishdev, Ajay Kumar, Vedpriya Arya

BioMedicine

Background: Metastasis of breast cancer cells to distant sites including lungs, liver, lymph node, brain and many more have substantially affected the overall survival outcome and distant metastasis free survival rate amongst the diseased individuals. Several pre-clinical and clinical studies were carried out to determine the potency of vigorous inhibitors but they extensively deteriorated the patient’s quality of life. Hence, there exists an urgent need to explore potent natural remedy to fight against metastatic breast cancer.

Methods: Ayurvedic medicinal plants documented in literature for their ability to fight against breast cancer was screened and their respective active moieties were evaluated …


In Vitro And In Silico Evaluation Of Andrographis Paniculata Ethanolic Crude Extracts On 3 Fatty Acid Synthase Expression On Breast Cancer Cells, Nur Amanina Johari, Nur Anisa Sapi’I, Alvin Lu Jiunn Hieng, Nurriza Ab Latif, Syazwani Itri Amran, Rosnani Hasham, Khairunadwa Jemon May 2024

In Vitro And In Silico Evaluation Of Andrographis Paniculata Ethanolic Crude Extracts On 3 Fatty Acid Synthase Expression On Breast Cancer Cells, Nur Amanina Johari, Nur Anisa Sapi’I, Alvin Lu Jiunn Hieng, Nurriza Ab Latif, Syazwani Itri Amran, Rosnani Hasham, Khairunadwa Jemon

BioMedicine

Background Fatty acid synthase (FASN), a key rate-limiting enzyme in the fatty acid biosynthesis pathway has been identified to be overexpressed in breast cancer. This overexpression has been affiliated with poor prognosis and resistance to chemotherapeutics. Consequently, FASN has come into focus as an appealing potential target for breast cancer treatment. Available FASN inhibitors, however, are unstable and have been correlated with adverse side effects. Objective This present study aims to investigate the potential of Andrographis paniculata ethanolic crude extract (AP) as a potent FASN inhibitor in breast cancer cells. Materials & Methods This study used MTT assay and flow …


Zinc Oxide Nanoparticles-Doped Curcumin-Assisted Recovery Of Rheumatoid Arthritis And Antioxidant Status In Experimental Rabbits, Shanza Azeez, Mishal Fatima, Ouz Gul, Huzaifa Rehman, Muhammad Aslam Shad, Haq Nawaz May 2024

Zinc Oxide Nanoparticles-Doped Curcumin-Assisted Recovery Of Rheumatoid Arthritis And Antioxidant Status In Experimental Rabbits, Shanza Azeez, Mishal Fatima, Ouz Gul, Huzaifa Rehman, Muhammad Aslam Shad, Haq Nawaz

BioMedicine

Introduction: Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by inflammation and synovial joint destruction.

Aims: The current study investigated the possible beneficial effect of zinc oxide nanoparticles-doped curcumin (ZnONPs-DC) on the recovery of RA and antioxidant status of experimental rabbits.

Methods: RA was induced in experimental rabbits by injecting complete Freund's adjuvant and collagen type-II emulsion (100 µL/kg body weight) in the base of their tail. Arthritic rabbits were orally treated with ZnONPs, curcumin, and ZnONPs-DC (250 µL/kg body weight). Serum samples from the control and study groups were collected before and after RA induction and after treatment. …


Protection Of Gueichih-Fuling-Wan On Cerebral Ischemia-Induced Brain Injury In Rodents Is Mediated By Trans-Cinnamaldehyde Via Inhibition Of Neuroinflammation And Apoptosis, Yuh-Fung Chen, Kuo-Jen Wu, Chi-Chung Kuo, Huei-Yann Tsai May 2024

Protection Of Gueichih-Fuling-Wan On Cerebral Ischemia-Induced Brain Injury In Rodents Is Mediated By Trans-Cinnamaldehyde Via Inhibition Of Neuroinflammation And Apoptosis, Yuh-Fung Chen, Kuo-Jen Wu, Chi-Chung Kuo, Huei-Yann Tsai

BioMedicine

Background: Stroke is the leading cause of mortality and morbidity worldwide, and an effective therapeutic strategy for the prevention of patients with cerebral ischemiainduced brain injury is lacking. Traditional Chinese medicine with neuroprotective activities might be beneficial and provide alternative therapeutic opportunities for cerebral ischemia.Purposes: This study aimed to evaluate the neuroprotection and possible mechanisms of Gueichih-Fuling-Wan (GFW), its’ constitutive herbs, and their active compounds on cerebral ischemia/reperfusion (I/R)-induced brain injury in rodents.Methods: Various doses of extracts (0.25, 0.5, and 1.0 g/kg) of GFW and five constituent herbs (Cinnamomi Cortex, CC; Poria cocos, PC; Paeonia lactifloa, PL; Paeonia suffruticosa, PS …


Glutaminase - A Potential Target For Cancer Treatment, Josephine Anthony, Sureka Varalakshmi, Ashok Kumar Sekar, Nalini Devarajan, Balamurugan Janakiraman, Rajendran Peramaiyan May 2024

Glutaminase - A Potential Target For Cancer Treatment, Josephine Anthony, Sureka Varalakshmi, Ashok Kumar Sekar, Nalini Devarajan, Balamurugan Janakiraman, Rajendran Peramaiyan

BioMedicine

The overexpression of glutaminase is reported to influence cancer growth and metastasis through glutaminolysis. Upregulation of glutamine catabolism is recently recognized as a critical feature of cancer, and cancer cells are observed to reprogram glutamine metabolism to maintain its survival and proliferation. Special focus is given on the glutaminase isoform, GLS1 (kidney type glutaminase), as the other isoform GLS2 (Liver type glutaminase) acts as a tumour suppressor in some conditions. Glutaminolysis linked with autophagy, which is mediated via mTORC1, also serves as a promising target for cancer therapy. Glutamine also plays a vital role in maintaining redox homeostasis. Inhibition of …


Unveiling The Power Of Flavonoids: A Dynamic Exploration Of Their Impact On Cancer Through Matrix Metalloproteinases Regulation, Peramaiyan Rajendran May 2024

Unveiling The Power Of Flavonoids: A Dynamic Exploration Of Their Impact On Cancer Through Matrix Metalloproteinases Regulation, Peramaiyan Rajendran

BioMedicine

Cancer is a prominent contributor to mortality rates globally, with its progression and spread being the primary factors underlying this assertion. Despite advancements in cancer therapy, the existing therapeutic strategies are rendered useless as a result of their toxicity and the development of chemoresistance. Hence, it is imperative to assess alternate therapy modalities, and natural compounds present a promising prospect due to their demonstrated anticancer capabilities in several research models. This article provides an overview of the regulatory mechanisms involved in the expression of metalloproteinases (MMPs) and explores the potential therapeutic function of flavonoids as agents with anticancer activity that …


Phytochemical Composition Of Clinacanthus Nutans Based On Factors Of Environment, Genetics And Postharvest Processes: A Review, Nurul Hamizah Sabindo, Rusidah Mat Yatim, Kannan Thirumulu Ponnuraj May 2024

Phytochemical Composition Of Clinacanthus Nutans Based On Factors Of Environment, Genetics And Postharvest Processes: A Review, Nurul Hamizah Sabindo, Rusidah Mat Yatim, Kannan Thirumulu Ponnuraj

BioMedicine

Herpes simplex, varicella-zoster lesions, skin rashes, diabetes, snake bites and insect bites have all been treated by using Clinacanthus nutans (C. nutans). The pharmacological effects of C. nutans are influenced by the presence of terpenoids, flavonoids, alkaloids, phenolic acids, saponins, glycosides, steroids and tannins. This review focused on the phytochemical makeup, which varies geographically and is a subject of scarcely existing knowledge. C. nutans served as the primary search term, while the keywords “phytochemicals”, “chemical component” and “phytochemistry” were used to search the literature in the Google Scholar, PubMed, Scopus and Web of Science databases. The articles pertinent to the …


Monetary Condition Index And Its Relation With Other Macroeconomic Variables: An Empirical Study In Selected Mena Countries, Jinan Jihad Kassem May 2024

Monetary Condition Index And Its Relation With Other Macroeconomic Variables: An Empirical Study In Selected Mena Countries, Jinan Jihad Kassem

BAU Journal - Creative Sustainable Development

This article aims to construct a monetary condition index (MCI) for five countries in the MENA region, namely Algeria, Bahrain, Egypt, Jordan, and Morocco, in order to interpret the stance of monetary policy in these countries. A broad MCI has been constructed by combining two transmission channels of monetary policy, the real interest rate and the real effective exchange rate, along with bank credit to the private sector. These three indicators of the monetary conditions are collected for these countries over the period 1995–2020 for all countries except for Bahrain, which has data from 1995 to 2015. Principal component analysis …


Effect Of Social Media On Shaping The Agenda Of The Communicator In The Jordanian Tv Channels, Amer Khaled Ahmad, Hamza Mohammad Nahar, Maram Mohammad Naji Manajreh May 2024

Effect Of Social Media On Shaping The Agenda Of The Communicator In The Jordanian Tv Channels, Amer Khaled Ahmad, Hamza Mohammad Nahar, Maram Mohammad Naji Manajreh


The study aimed to assess the extent to which communicators at Jordanian television channels use social media platforms as an information source, and the impact of these platforms on their news and information selection priorities. This was achieved using a survey tool distributed on an equal quota sample of (150) communicators from Jordanian television channels (Jordan TV, AlMamlaka TV, Roya TV). The study found that all the study subjects used social media platforms as a source of information, with the "X platform (formerly Twitter)" being the most used platform. The statement "understanding the audience's interests and preferences to produce tailored …