Life Sciences Commons^™

Development Of A Novel Comprehensive Hepatocellular Carcinoma Outcome Prognostic Scoring System With Integration Of Imaging Features, Hop S Tran Cao, Russell G Witt, Khaled M Elsayes, Ali A Baiomy, Lianchun Xiao, Sunyoung S Lee, Armeen Mahvash, Ching-Wei D Tzeng, Yun Shin Chun, Eugene Jon Koay, Asif Rashid, Manal M Hassan, James C Yao, Jean-Nicolas Vauthey, Ahmed O Kaseb

Faculty, Staff and Student Publications

Background: Accurate prognostic stratification of hepatocellular carcinoma (HCC) is vital for clinical trial enrollment and treatment allocation. Multiple scoring systems have been created to predict patient survival, but no standardized scoring systems account for radiologic tumor features. We sought to create a generalizable scoring system for HCC which incorporates standardized radiologic tumor features and more accurately predicts overall survival (OS) than established systems.

Methods: Clinicopathologic parameters were collected from a prospectively collected cohort of patients with HCC treated at a single institution. Imaging studies were evaluated for tumor characteristics. Patients were randomly divided into a training set for identification of …

Nanoparticles As Antioxidant Agents: A Comprehensive Review, Sulyman Olalekan Ibrahim, Halimat Yusuf Lukman, Fatimat Ronke Abdulkadir, Monsurat Yemisi Bello, Yusuf Oloruntoyin Ayipo, Halimah Funmilayo Babamale, Marili Funmilayo Zubair, Olubunmi Atolani

Al-Bahir

This study seeks to provide a comprehensive overview of the latest progress in the antioxidant properties of nanoparticles. Nanoparticles (NPs) have emerged as a promising tool in several domains of science and industry, including their application as antioxidant agents. The main knowledge gaps seem to be in correctly identifying the make-up of the naturally occurring phytochemicals that give these nano-antioxidants their extraordinary pharmacology and drug-like properties. In many instances, that characterization is done using spectroscopy instrumentation such as fourier-transform Infrared (FT-IR), scanning electron microscope (SEM), and X-ray diffraction analysis (XRD). From literature appraisals, it was discovered that a lot of …

Differentiation Between Descending Thoracic Aortic Diseases Using Machine Learning And Plasma Proteomic Signatures, Amanda Momenzadeh, Simion Kreimer, Dongchuan Guo, Matthew Ayres, Daniel Berman, Prediman K Shah, Ali Azizzadeh, Jesse G Meyer, Sarah Parker

Faculty, Staff and Student Publications

BACKGROUND: Descending thoracic aortic aneurysms and dissections can go undetected until severe and catastrophic, and few clinical indices exist to screen for aneurysms or predict risk of dissection.

METHODS: This study generated a plasma proteomic dataset from 75 patients with descending type B dissection (Type B) and 62 patients with descending thoracic aortic aneurysm (DTAA). Standard statistical approaches were compared to supervised machine learning (ML) algorithms to distinguish Type B from DTAA cases. Quantitatively similar proteins were clustered based on linkage distance from hierarchical clustering and ML models were trained with uncorrelated protein lists across various linkage distances with hyperparameter …

The Effects Of A Brand-Specific, Hemp-Derived Cannabidiol Product On Physiological, Biochemical, And Psychometric Outcomes In Healthy Adults: A Double-Blind, Randomized Clinical Trial, Gianna F. Mastrofini, Bridget A. Mcfadden, Alexa J. Chandler, Blaine S. Lints, Harry P. Cintineo, Nathaniel D. Rhoades, Caroline S. Vincenty, Sten O. Stray-Gundersen, Abbi D. Lane, Shawn M. Arent

Faculty Scholarship

Background

Cannabidiol (CBD) is a non-psychoactive phyto-cannabinoid derived from the Cannabis sativa plant. CBD exhibits various interactions at receptor sites, prompting the research of its potential anti-inflammatory, immunomodulatory, psychological, and pain-relieving effects. This study aimed to investigate the physiological, biochemical, and psychometric effects of a brand-specific, hemp-derived CBD product in healthy adults over a 12-week observation period.

Methods

54 healthy males and females (age = 25 ± 7y; BMI = 24.82 ± 3.25 kg/m2) recruited from a large Southeastern University completed the study. Participants arrived at the laboratory after > 8 h of fasting, and > 48 h without alcohol consumption and …

Education And Land Management On The Pacific Crest Trail Phase 4, Ben Sherman, Emma Perry, Cade Cappello, Hattie Cahill, Anna Macklyn, Aidan Tull, Tristian Xu, Augrey Gregg

Baker/Koob Endowments Awarded Projects

This research is a continuation of research collected on the Pacific Crest Trail (PCT). The purpose of this study was to investigate land ethics and education, Leave No Trace principles, and hiker experiences on the PCT. From July 2023-January 2024, interdisciplinary students collected qualitative and quantitative data through interviews and surveys with hikers on the trail. Past phases of this project have determined that this research is necessary, but due to Covid, the team has only been able to gather data remotely via online surveys and interviews prior to this study. The Baker Koob grant funded travel and research equipment …

The Impact Of Concussion History On Balance Performance In Collegiate Football Players, Cade R. Montgomery, Evan Braesch

Applied Health Sciences Student Works

This study aims to investigate the enduring impact of prior sport-related concussions on static and dynamic balance performance among collegiate football players. Twenty-six players (n=26), half with a history of diagnosed concussions (n=13). underwent balance testing using the Biosway Balance Error Scoring Scale test (BESS) for static balance, and the Y-Balance test (YBT) for dynamic balance. The Biosway test revealed notable statistical discrepancies in BESS composite scores between groups (p=0.010) and individual test items such as single leg stance with eyes closed (p=0.034) and tandem stance with eyes closed (p=0.030). No significant difference in the YBT composite scores between groups, …

Non-Native Invasive Earthworms In The Midwest And Eastern United States: A Primer, Adrienne B. Keller, Stephen Handler

Michigan Tech Publications

Prior to European settlement, earthworms were rare across most of the Midwest and Eastern United States (James 1995). This is presumably because earthworms were slow to recolonize after the last glacial period. Currently, earthworms of European and Asian origin are invading this region with demonstrable effects on soil characteristics and ecosystem functions. Eradicating non-native invasive earthworms (hereafter, “earthworms”) is generally not a realistic management goal. Still, understanding how earthworms act as ecosystem engineers will aid land managers in considering how earthworms modify local effects of climate change and management actions on natural ecosystems. Additionally, where earthworms have not yet invaded, …

Soil Organic Carbon In Temperate Managed Ecosystems : A Primer, Adrienne B. Keller, Stephen D. Handler

Michigan Tech Publications

Soils store more carbon than the atmosphere and vegetation combined, an impressive fact that underscores the importance of considering soils when managing for ecosystem carbon. Not only do soils store vast amounts of carbon, but soil carbon also persists in the ecosystem for much longer than other pools of carbon. This primer is an introduction to soil organic carbon storage, sequestration, and cycling in terrestrial managed ecosystems. The effects of site factors, climate change, and management on soil carbon are discussed.

Rewiring The Sex-Determination Pathway During The Evolution Of Self-Fertility., Yongquan Shen, Shin-Yi Lin, Jonathan Harbin, Richa Amin, Allison Vassalotti, Joseph Romanowski, Emily Schmidt, Alexis Tierney, Ronald E Ellis

Rowan-Virtua School of Osteopathic Medicine Departmental Research

Although evolution is driven by changes in how regulatory pathways control development, we know little about the molecular details underlying these transitions. The TRA-2 domain that mediates contact with TRA-1 is conserved in Caenorhabditis. By comparing the interaction of these proteins in two species, we identified a striking change in how sexual development is controlled. Identical mutations in this domain promote oogenesis in Caenorhabditis elegans but promote spermatogenesis in Caenorhabditis briggsae. Furthermore, the effects of these mutations involve the male-promoting gene fem-3 in C. elegans but are independent of fem-3 in C. briggsae. Finally, reciprocal mutations in these genes show …

Nebline, June/July 2024

NEBLINE Newsletter Archive from Nebraska Extension in Lancaster County

Per- and Polyfluoroalkyl Substances (PFAS) Facts Related to Drinking Water by Becky Schuerman

Tar Spot is an Emerging Corn Disease in Eastern Nebraska by John Nelson

Nutrition Education for Refugee and Immigrant Families in Lincoln by Emily Gratopp

Recipe of the Month: Biryani by Emily Gratopp

Garden Guide: Things to Do This Month

Sudden Wilt and Death in Tomatoes by Sarah Browning

Sun's Out, Fun's Out: Keeping Your Little One Safe This Summer by Hayley Perez

Protect Yourself from Bed Bugs by Kait Chapman

Heart of 4-H Volunteer Award: Netsy Barent and Jessica Marsh

Nebraska 4-H Foundation Scholarship Winners

Learn …

Herbicides, Department Of Primary Industries And Regional Development, Western Australia

Grains and other field crops factsheets

Herbicides play a vital role in integrated weed management programs. Knowledge of the mechanisms and activity of herbicides will improve the impact and sustainability of herbicides as a weed management tactic. This fact sheet is a guide to the types of herbicides available and when and how they should be used.

Cultivating Agriculture - Cultivando Agricultura: Content Creator, Sophia L. Garcia

Agricultural Education: Graduate Internship Reports

Agriculture is rooted in culture, yet we rarely discuss the people who drive the industry today. Many voices have yet to share their stories of influencing or making a difference in the agriculture industry. As a result, the idea of a podcast arose as a free, convenient, and accessible way for everyone to hear and communicate stories. During the project, my co-host, Daniela Ramos, and I will work together to address this issue. To diversify and separate the workload, we will each host three episodes individually. As part of my role, I will also be responsible for marketing, including creating …

Neuronal Lrp4 Directs The Development, Maturation And Cytoskeletal Organization Of Drosophila Peripheral Synapses, Alison Depew, Joseph Bruckner, Kate O'Connor-Giles, Timothy Mosca

Student Papers, Posters & Projects

Synaptic development requires multiple signaling pathways to ensure successful connections. Transmembrane receptors are optimally positioned to connect the synapse and the rest of the neuron, often acting as synaptic organizers to synchronize downstream events. One such organizer, the LDL receptor-related protein LRP4, is a cell surface receptor that has been most well-studied postsynaptically at mammalian neuromuscular junctions. Recent work, however, identified emerging roles, but how LRP4 acts as a presynaptic organizer and the downstream mechanisms of LRP4 are not well understood. Here, we show that LRP4 functions presynaptically at Drosophila neuromuscular synapses, acting in motoneurons to instruct pre- and postsynaptic …

Fabrication Of A Low-Cost Drum Seeder For Paddy, Muhammad Rashed Al Mamun, Md Rejaul Karim, Md Towfiqur Rahman, Md Janibul Alam Soeb, Md Imranul Alam

Department of Agricultural and Biological Systems Engineering: Faculty Publications

Rice is a staple food crop. Bangladesh produces it extensively which raised the nation into the fourth-largest rice-grower in the world. Transplanting or direct seeding is a major task in rice cultivation where the manual transplanting method requires a huge labor cost which is beyond control in a peak season. Although mechanical rice transplanters become popularization land preparation and seedling rising as a pre transplanting task is costly and labor-intensive. On the other hand, manual broadcasting and machine seeding direct method still exist due to the above method’s problem. Considering spacing accuracies for intercultural operation, drum seeders are an easy …

Geographic Distribution: Smilisca Baudinii (Mexican Treefrog). Usa: Florida: Escambia Co., Louis A. Somma, Justin K. Anto, Jakira A. Davis

Papers in Herpetology

Geographic distribution note for Smilisca baudinii, the Mexican treefrog, from Escambia County, Florida, United States.

Forage News [2024-06], University Of Kentucky

Forage News

No abstract provided.

Neural Mechanisms Of Respiratory Interoception, Pei-Ying Sarah Chan, Lu-Yuan Lee, Paul W. Davenport

UK CARES Faculty Publications

Respiratory interoception is one of the internal bodily systems that is comprised of different types of somatic and visceral sensations elicited by different patterns of afferent input and respiratory motor drive mediating multiple respiratory modalities. Respiratory interoception is a complex system, having multiple afferents grouped into afferent clusters and projecting into both discriminative and affective centers that are directly related to the behavioral assessment of breathing. The multi-afferent system provides a spectrum of input that result in the ability to interpret the different types of respiratory interceptive sensations. This can result in a response, commonly reported as breathlessness or dyspnea. …

Nou Spring Field Days And Annual Meeting, 125th Anniversary Of The Nebraska Ornithologists’ Union, Birding Bowl Kickoff Weekend, Lincoln, Mary 3–5, 2024, Janis Paseka

Nebraska Bird Review

The NOU Annual Meeting and Spring Field Days were held in Lincoln on May 3-5, 2024, with 80 in attendance. This year is the 125th anniversary of the founding of the Nebraska Ornithologists’ Union, and this meeting also served as the kickoff of the Nebraska Birding Bowl.

Field trips were led by Olivia DaRugna, Thane Dinsdale, Joe Gubanyi, Thomas Labedz, Jason St. Sauver, T. J. Walker, and Michael Willison. Destinations included Wilderness Park, Bluestem Lake SRA, Killdeer WMA, Cottontail WMA, Pawnee Lake SRA, Branched Oak Lake, Butler County Prairie-Chicken lek, Marsh Wren Saline Wetland, Spring Creek Prairie, and Conestoga Lake …

The Nebraska Bird Review (June 2024) 92(2), Whole Issue

Nebraska Bird Review

Spring Field Report, March–May 2024, by W. Ross Silcock

The Early Years of the Nebraska Ornithologists’ Union: People and Publications, by Daniel W. Leger

NOU Spring Field Days and Annual Meeting, 125th Anniversary of the Nebraska Ornithologists’ Union, Birding Bowl Kickoff Weekend, Lincoln, May 3–5, 2024, by Janis Paseka

Subscription and Organization Information

Spring Field Report, March–May 2024, W. Ross Silcock

Nebraska Bird Review

A major concern this spring was the widely lamented shortfall in numbers of migrant warblers and the shortened duration of the migration, with most sightings relatively early. Numbers of migrant warblers east of the 100th meridian were investigated by Joel Jorgensen and Stephen Brenner and the scarcity was indeed found to be supported by eBird data; see the “News and Updates” section in Birds of Nebraska-Online (BONO). At Oliver Reservoir in the Panhandle, however, Steven Mlodinow found that migration was at least normal for a range of common migrants, with some migrants above the levels of the last four years. …

Manage Crop Weeds At Harvest, Department Of Primary Industries And Regional Development, Western Australia

Grains and other field crops factsheets

This management strategy provides an opportunity to control weed seed set in the pasture and during harvest. The strategy physically removes viable seed from the paddock by collecting weed seed and grazing crop residues.

Weed seed removal at harvest can be achieved in 2 ways:

1. collecting weed seeds from the system to prevent them being spread across the paddock or farm

2. grazing weed contaminated crop residue and pastures.

Herbicide Application, Department Of Primary Industries And Regional Development, Western Australia

Grains and other field crops factsheets

Herbicides can be applied by a variety of means, including boom sprayers, aerial spraying, misters, blanket wipers, rope wick applicators, weed seekers and back-pack sprayers. This fact sheet reviews the different methods, including nozzles and calibration of equipment, used to apply herbicides.

Capture Rates Of Eptesicus Fuscus Increase Following White-Nose Syndrome Across The Eastern Us, Molly C. Simonis, Lynn K. Hartzler, Gregory G. Turner, Michael R. Scafini, Joseph S. Johnson, Megan A. Rúa

Biological Sciences Faculty Publications

Emerging infectious diseases threaten wildlife globally. While the effects of infectious diseases on hosts with severe infections and high mortality rates often receive considerable attention, effects on hosts that persist despite infection are less frequently studied. To understand how persisting host populations change in the face of disease, we quantified changes to the capture rates of Eptesicus fuscus (big brown bats), a persisting species susceptible to infection by the invasive fungal pathogen Pseudogymnoascus destructans (Pd; causative agent for white-nose syndrome), across the eastern US using a 30-year dataset. Capture rates of male and female E. fuscus increased from preinvasion to …

The Most Outstanding—Recognizing Achievements Through Ashs Publication Awards: A Brief History Of Publications And An Introduction To Publication Awards, Curt R. Rom

Horticulture Faculty Publications and Presentations

The American Society for Horticultural Science (ASHS) has since its inception published annual serial monographs or journals to achieve its mission of communicating horticultural science. To recognize the accomplishments of the membership, a series of professional awards was created. After the individual awards, the ASHS created publication awards. This paper, and the papers that follow, document the publication awards of the ASHS. The papers were based on presentations at the 2023 annual conference and serve as additional recognition of the contributions of member authors and as a historical record of achievements of the ASHS.

Evolution And Adaptation To Temperature In Thermotogota, Anne Amelia Farrell

Dartmouth College Ph.D Dissertations

Life thrives across incredibly diverse environmental conditions, yet most organisms are restricted to growing within a narrow range around their optimum growth temperature (OGT). The evolutionary events leading to changes in OGT are poorly understood, and it is uncertain if specific genes are required to thrive at a particular temperature. The bacterial phylum Thermotogota is an excellent model for the evolution of OGT. It comprises mesophilic, thermophilic, and hyperthermophilic members that collectively grow between 20°C and 90°C.

In this work, I analyze the history of OGT in the Thermotogota phylum and show how horizontal gene transfer contributes to the evolution …

The Effect Of Probiotic Supplementation On Serum Metabolite Concentrations In Young Holstein Heifers, Emily G. Meissner

Master's Theses

The objective of this trial was to evaluate the effect of a multi-strain probiotic on serum concentrations of selected metabolites in young calves. Holstein heifers (n = 112) from a commercial dairy were enrolled within 48 h of birth and placed into individual hutches. Calves were weaned at 60 d of age and remained in their hutches until 90 d of age, when they were moved to group housing. Calves were placed into 2 treatment groups: 1) control and 2) B. subtilis, B. lichenformis, L. animalis, and P. freudenreichii probiotic (Bovamine Dairy Plus, Chr. Hansen, Milwaukee, WI). Control calves received …

Naturify 2300, Yarina Yiwei Dai

Masters Theses

In my art practice, I explore the interplay between human desires to manipulate and anthropomorphize nature, as seen in the technological augmentation of plants and living entities. This investigation delves into how this intersection, alongside empathy towards these creations, contributes to fears of uncontrollability and the risks of addiction and excessive dependence on technology.

Bioengineering and genetic modification have cultivated unprecedented developments, allowing humans to manipulate the fundamental building blocks of life. My research speculates on this technology further, modifying the genetic code of organisms and creating bioengineered wearable entities with enhanced traits or entirely new functionalities. The primary objective …

The Mayfly Newsletter, Donna Giberson

The Mayfly Newsletter

The Mayfly Newsletter is the official newsletter of the Permanent Committee of the International Conferences on Ephemeroptera.

Dietary Probiotic Supplement Attenuates Methamphetamine-Induced Conditioned Place Preference In Female Sprague-Dawley Rats, Kristen Powell

Masters Theses

Substance use disorders (SUD) represent a global public health crisis with limited effective treatment options. Recent findings implicate the gut microbiome and gut/brain axis in the pathophysiology of SUDs. Several preclinical studies have established that psychostimulants alter gut microbiome composition, but no published studies have assessed behavioral effects of dietary probiotic supplements on drug-induced behavioral changes. This study utilized rodent conditioned place preference (CPP) as a behavioral index of conditioned drug reward to determine if a dietary probiotic supplement alters the behavioral effects of (+)-methamphetamine (METH). Fifty-four adult female Sprague-Dawley rats were randomly assigned to receive either a standard rodent …

(R2071) Global Stability Analysis Of Chikv Dynamics Model With Adaptive Immunity And Distributed Time Delays, Taofeek O. Alade, Samson Olaniyi, Hassan A. Idris, Yaqoob Al Rahbi, Mohammad Alnegga

Applications and Applied Mathematics: An International Journal (AAM)

The application of mathematical biology and dynamical systems has proven to be an effective approach for studying viral infection models. To contribute to this research, our paper proposes a new CHIKV model that takes into account an adaptive immune response and distributed time delays, which accurately reflects the time lag between initial viral contacts and the production of new active CHIKV particles. By analyzing the model’s qualitative behavior, we establish a biological threshold number that can predict whether CHIKV will be cleared from or persist in the body. We demonstrate the global stability of both CHIKV-present and CHIKV-free steady states …