Life Sciences Commons^™

Loss Of The Dna Repair Gene Rnase H2 Identifies A Unique Subset Of Ddr-Deficient Leiomyosarcomas, Michael S Nakazawa, Ian M Silverman, Victoria Rimkunas, Artur Veloso, Dominik Glodzik, Toshiro K Ohsumi, Anthony P Conley, Christina L Roland, Pamela T Soliman, Hannah C Beird, Chia-Chin Wu, Davis R Ingram, Rossana Lazcano, Dawon Song, Khalida M Wani, Alexander J Lazar, Timothy A Yap, Wei-Lien Wang, J Andrew Livingston

Faculty, Staff and Student Publications

Targeting the DNA damage response (DDR) pathway is an emerging therapeutic approach for leiomyosarcoma (LMS), and loss of RNase H2, a DDR pathway member, is a potentially actionable alteration for DDR-targeted treatments. Therefore, we designed a protein- and genomic-based RNase H2 screening assay to determine its prevalence and prognostic significance. Using a selective RNase H2 antibody on a pan-tumor microarray (TMA), RNase H2 loss was more common in LMS (11.5%, 9/78) than across all tumors (3.8%, 32/843). In a separate LMS cohort, RNase H2 deficiency was confirmed in uterine LMS (U-LMS, 21%, 23/108) and soft-tissue LMS (ST-LMS; 30%, 39/102). In …

Inhibition Of Malt1 And Bcl2 Induces Synergistic Antitumor Activity In Models Of B-Cell Lymphoma, Joshua P Plotnik, Adam E Richardson, Haopeng Yang, Estela Rojas, Velitchka Bontcheva, Sydney Parsons, Vida Ravanmehr, Christine Will, Paul Jung, Haizhong Zhu, Sarathy Karunan Partha, Sanjay C Panchal, Raghuveer Singh Mali, Frederick J Kohlhapp, Ryan A Mcclure, Cyril Y Ramathal, Mariam D George, Manisha Jhala, Nathaniel L Elsen, Wei Qiu, Russell A Judge, Chin Pan, Anthony Mastracchio, Jared Henderson, Jonathan A Meulbroek, Michael R Green, William N Pappano

Faculty, Staff and Student Publications

The activated B cell (ABC) subset of diffuse large B-cell lymphoma (DLBCL) is characterized by chronic B-cell receptor signaling and associated with poor outcomes when treated with standard therapy. In ABC-DLBCL, MALT1 is a core enzyme that is constitutively activated by stimulation of the B-cell receptor or gain-of-function mutations in upstream components of the signaling pathway, making it an attractive therapeutic target. We discovered a novel small-molecule inhibitor, ABBV-MALT1, that potently shuts down B-cell signaling selectively in ABC-DLBCL preclinical models leading to potent cell growth and xenograft inhibition. We also identified a rational combination partner for ABBV-MALT1 in the BCL2 …

Media Optimization Techniques For Microalgae Through Technological Advancements: A Mini Review, Khairul A. Radzun, Hasan M. Agha, Nur Farrahim F. Abdullah, Mas I. Ahmad, Igor Ivanovski, Amjad A. Mohammed, Abdulmutalib Alabeed Alkamil

AUIQ Complementary Biological System

Microalgae have been classified as the most primitive plant species and the ability to grow rapidly makes it very suitable for biomass cultivation by using different technologies over the past years. Microalgal biomass can be used for various productions such as biofuels, food, supplements, and more as it is categorized as environmentally friendly throughout the cultivation process. Nutrients play one of the most important roles in cultivating microalgae besides other factors such as temperature, pH, salinity, inorganic carbon, oxygen, light intensity, and carbon dioxide availability. The technology has become much more advanced in cultivating microalgae for maximizing lipid or biomass …

Improved Efficiency And Sensitivity Analysis Of 3-D Agent-Based Model For Pain-Related Neural Activity In The Amygdala, Kayla Kraeuter, Carley Reith, Benedict J. Kolber, Rachael Miller Neilan

Spora: A Journal of Biomathematics

Neuropathic pain is caused by nerve injury and involves brain areas such as the central nucleus of the amygdala (CeA). We developed the first 3-D agent-based model (ABM) of neuropathic pain-related neurons in the CeA using NetLogo3D. The execution time of a single ABM simulation using realistic parameters (e.g., 13,000 neurons and 22,000+ neural connections) is an important factor in the model’s usability. In this paper, we describe our efforts to improve the computational efficiency of our 3-D ABM, which resulted in a 28% reduction in execution time on average for a typical simulation. With this upgraded model, we performed …

The Effect Of Chemical Coagulant Dosages On The Removal Of Turbidity From Wastewater, Estabraq Ali Hameed, Rodhan Abdullah Salih, Ali Mohammed Saleh, Hussein M. Issa, Mahmod A. Abdulqader

AUIQ Complementary Biological System

This research aims to compare different coagulants, which are alum, ferric chloride, and polyaluminum chloride, in treating turbidity in water. The objective is to determine the optimal dosage of each coagulant for the removal of visible turbidity at levels of 400, 85, 70, and 40 NTU, respectively. The study also considers the (pH) levels resulting from the addition of coagulants, measures the percentage of remaining materials from the used coagulant (sulfates from alum, chloride from ferric chloride, and chlorides from polyaluminum chloride). A 1000 l tank and its components were controlled by adding the desired pollutants (clay and plant impurities) …

Consequences Of Global Climate Change On Biodiversity And Food Security: A Mini Review, Hasan M. Agha, Abdulmutalib Alabeed Alkamil, Rana Tariq Yahya, Amjad Abdulhadi Mohammed, Zaid Tahseen Ali, Muneer Mohammed Saleh Alsayadi

AUIQ Complementary Biological System

A thriving eco-system and abundant species diversity are crucial for all forms of life on Earth. Whether or not the climate remains stable has a direct impact on biodiversity and the ecosystem services that are provided by that diversity. There is a strong correlation between biodiversity and food security, and this is influencing how the impact of biodiversity on climate change is felt. Changes in the duration of the growth season for plants, the distribution of arable lands, and the availability of high-quality water are all ways in which climate change impacts agriculture. There will be numerous positive effects on …

Evaluation Of Bnp, Upa And Wint5a In Four Stages Of Iraqi Patients With Heart Failure, Raghda Faris Salim, Wafaa Raji Alfatlawi, Muhammed A.H. Aldabagh

AUIQ Complementary Biological System

Heart disease is classified as one of the most serious and widespread diseases in the world, presenting major challenges to public health and leading to high mortality rates. A comprehensive understanding of its causative factors, along with early recognition of signs and symptoms, is essential to achieve rapid diagnosis and promote preventive measures. This research conducted on 100 Iraqi patients divided into four stages according to the criteria of the American College of Cardiology, where each stage includes 25 patients suffering from heart disease. Their ages ranges (40 -75) years. A comparative analysis was performed with 50 healthy individuals serving …

The Importance, Issues And Challenges Of Large Mammal's Conservation In Malaysia, Hasan M. Agha, Abdulmutalib Alabeed Alkamil, Suqi Wang, Abbas Ismayilov, Amjad Abdulhadi Mohammed

AUIQ Complementary Biological System

Malaysia's biodiversity is one of the most important factors that have made the country a habitat for numerous species. Where the tropical climate and rainforests provide an ideal habitat for numerous plants and animals. Massive mammals are among the most important creatures found in Malaysia, and the Malaysian peninsula is home to unique species of mammals. Due to the modification of their living environment, urban development, urban expansion, and population growth have significantly reduced the number of these mammals. Damage to habitats and a decline in large mammal populations have had far-reaching consequences for the ecosystem, with the potential for …

Beyond The Scalpel: Understanding Acute Kidney Problems After Heart Surgery, Navakanth Raju Ramayanam, Sarad Pawar Naik Bukke, Hari Babu Ramenani, Saira Patan, Niranjan Ponna, Supriya Pilliboina, Sahanaz Pinjari, Sri Sathyavathi D., Narayana Goruntla, Tadele Mekuriya Yadesa

AUIQ Complementary Biological System

Acute renal injury (ARI) post cardiac surgery leads to substantial difficulty in going about the treatment, that often results in aggravated morbidity and mortality rates. Through this manuscript, we have the opportunity to cover a basic assessment of ARI complexity, including comorbidities which have been categorized as preoperative, intraoperative, and postoperative factors. The risk of all these ailments may also increase which is due to advanced age and comorbidities such as diabetes and hypertension and may lead to procedures like cardiopulmonary bypass (CPB) and duration of cardiopulmonary bypass. The cardiac procedures under discussion like the Coronary artery bypass surgery (CABG) …

Conversion Of Chicken Rice Waste Into Char Via Hydrothermal, Pyrolysis, And Microwave Carbonization Processes: A Comparative Study, Mahmod A. Abdulqader, Muhammad Akromin Suliman, Tabit Abas Ahmed, Ruihong Wu, Aiman. M. Bobaker, Tiyasha Tiyasha, Mohamed A. Yassin, Nabil Al-Areeq

AUIQ Complementary Biological System

This study aims to convert chicken rice waste (CRW) to chars by hydrothermal carbonatization (HTC), pyrolysis (PY), and microwave irradiation (MW) processes. The operating parameters affecting the HTC process (range of temperatures 120, 140, 160, 180, and 200 °C) for hydro-char production, while the pyrolysis (range of temperatures 400, 500, 600, and 700 ^°C) for pyro-char production, and microwave irradiation (range of microwave power 200, 400, 600, and 800 W) for micro-char production were investigated. Comparative studies of the physicochemical properties of produced chars were investigated by Brunauer-Emmett-Teller (BET), X-ray diffraction (XRD), Fourier transform infrared (FTIR), and scanning electron …

How Will Climate Change-Induced Increases In Wildfire Frequency Affect Soil Microbial Communities?, Bahar Saadaie Jahromi, David Karowe

Waldo Library Student Exhibits

As climate change progresses, wildfires will become more common, increasing their impact on soil microbial ecosystems. This research examines how increased fire frequency affects soil microbial communities and whether effects differ for communities associated with different tree species. Soil samples were collected from under five individuals of four tree species within each of four 1-ha plots that had experienced fire from 24 to 111 years ago. Samples were analyzed for microbial DNA using next generation sequencing techniques in order to explore the influence of fire return interval and tree species on microbial diversity and community structure. Correlations were also examined …

National Parks Field Journal, Isadora Davis

Art and Design Student Scholarship and Projects

A handwritten, richly illustrated field journal by Binghamton University art major Isadora Davis, recording a trip through national parks in the American West via SUNY Broome's BIO 217: Ecology of National Parks. Davis uses colored pencil drawings and pressed botanical specimens to record landscapes, birds, mammals, and plant life in Grand Teton, Yellowstone, Wind Cave, and Badlands National Parks, as well as Custer State Park. Davis's sketches and diagrams visually explore how to decode past landscapes from current formations, while her written entries explain species diversity, animal behavior, and the mechanisms causing geological formations and geothermal events. Part memoir of …

Evaluating 45 Years Of Collaborative Range Livestock Education, Melanie Heaton, Andrew Brischke, Ben Scow

Outcomes and Impact Quarterly

The Arizona/Utah Range Livestock Workshop & Tour builds cooperation and understanding between public land grazing permittees and federal agency personnel through science-based education. The workshop provides information on livestock production practices and addresses controversial grazing issues in a non-confrontational environment. Topics range from animal handling, vaccination, and health to solar development, partnering with public land agencies, and recreation effects.

Wildlife Conservation: The Importance Of Individual Personality Traits And Sentience, Karen A. Owens, Gosia Bryja, Marc Bekoff

Animal Sentience

Individual differences in personality types within the same species have been studied much less than differences between species and populations. Personality differences are related to risk-taking and exploration, which in turn correlate with individuals' daily responses, decisions, and fitness. Bold and shy personality types can have different advantages and disadvantages under different social or environmental pressures. Analyzing personality differences has helped clarify how elk habituate to a well-populated area and how management strategies can be adapted to them. For wolves newly repatriated to Colorado, individual personality factors are likely to prove important for adapting to their new homes as well …

Effects Of Fire On Ecosystem Carbon In The Upper Midwest And Northeast United States : A Primer, Adrienne B. Keller, Stephen D. Handler

Michigan Tech Publications

Prior to European settlement, fire was a common disturbance across most of the Midwest and Eastern United States. Today, prescribed fire is used as a management tool to promote native, fire-tolerant species and reduce vulnerability to high-intensity, unplanned fires. This primer discusses how prescribed fire affects ecosystem structure and function, with a primary focus on ecosystem carbon storage and sequestration. Management considerations related to the effects of prescribed fire on ecosystem carbon and greenhouse gas mitigation goals are discussed.

Using Machine Learning To Determine A Functional Classifier Of Reward Responsiveness And Its Association With Adolescent Psychiatric Symptomatology, Robert James Richard Blair, Johannah Bashford-Largo, Ahria Dominguez, Matthew Dobbertin, Karina S. Blair, Sahil Bajaj

Center for Brain, Biology, and Behavior: Faculty Publications

Background. Machine learning (ML) has developed classifiers differentiating patient groups despite concerns regarding diagnostic reliability. An alternative strategy, used here, is to develop a functional classifier (hyperplane) (e.g. distinguishing the neural responses to received reward v. received punishment in typically developing (TD) adolescents) and then determine the functional integrity of the response (reward response distance from the hyperplane) in adolescents with externalizing and internalizing conditions and its associations with symptom clusters.

Methods. Two hundred and ninety nine adolescents (mean age = 15.07 ± 2.30 years, 117 females) were divided into three groups: a training sample of TD adolescents …

Second Language Learning In Older Adults Modulates Stroop Task Performance And Brain Activation, Douglas H. Schultz, Alison Gansemer, Kiley Allgood, Mariah Gentz, Lauren Secilmis, Zoha Deldar, Cary R. Savage, Ladan Ghazi Saidi

Center for Brain, Biology, and Behavior: Faculty Publications

Introduction: Numerous studies have highlighted cognitive benefits in lifelong bilinguals during aging, manifesting as superior performance on cognitive tasks compared to monolingual counterparts. Yet, the cognitive impacts of acquiring a new language in older adulthood remain unexplored. In this study, we assessed both behavioral and fMRI responses during a Stroop task in older adults, pre- and post language-learning intervention.

Methods: A group of 41 participants (age: 60–80) from a predominantly monolingual environment underwent a four-month online language course, selecting a new language of their preference. This intervention mandated engagement for 90 minutes a day, five days a week. …

In Search Of The Locus Coeruleus: Guidelines For Identifying Anatomical Boundaries And Electrophysiological Properties Of The Blue Spot In Mice, Fish, Finches, And Beyond, Amelien Vreven, Gary Aston-Jones, Anthony E Pickering, Gina R Poe, Barry Waterhouse, Nelson K Totah

Rowan-Virtua School of Osteopathic Medicine Departmental Research

Our understanding of human brain function can be greatly aided by studying analogous brain structures in other organisms. One brain structure with neurochemical and anatomical homology throughout vertebrate species is the locus coeruleus (LC), a small collection of norepinephrine (NE)-containing neurons in the brainstem that project throughout the central nervous system. The LC is involved in nearly every aspect of brain function, including arousal and learning, which has been extensively examined in rats and nonhuman primates using single-unit recordings. Recent work has expanded into putative LC single-unit electrophysiological recordings in a nonmodel species, the zebra finch. Given the importance of …

A Versatile, Semi-Automated Image Analysis Workflow For Time-Lapse Camera Trap Image Classification, Gerardo Celis, Peter Ungar, Aleksandr Sokolov, Natalia Sokolova, Hannah Bohner, Desheng Liu, Olivier Gilg, Ivan Fufachev, Olga Pokrovskaya, Rolf Anker Ims, Wenbo Zhou, Dan Morris, Dorothee Ehrich

Anthropology Faculty Publications and Presentations

Camera traps are a powerful, practical, and non-invasive method used widely to monitor animal communities and evaluate management actions. However, camera trap arrays can generate thousands to millions of images that require significant time and effort to review. Computer vision has emerged as a tool to accelerate this image review process. We propose a multi-step, semi-automated workflow which takes advantage of site-specific and generalizable models to improve detections and consists of (1) automatically identifying and removing low-quality images in parallel with classification into animals, humans, vehicles, and empty, (2) automatically cropping objects from images and classifying them (rock, bait, empty, …

The Influence Of Resource Patch Condition And Size On Social Interactions, Reproductive Behaviors, And Oviposition In A Fungivorous Beetle, Lillian J. Fornoff , '21, C. A. Stahlmann Roeder, E. D. Brodie Iii, Vincent A. Formica

Biology Faculty Works

Variation among resource patches can structure spatial patterns of social behavior. Individual preferences and requirements for heterogeneous resources can lead to differences in where behaviors take place and which kinds of individuals interact. In this study we examined whether properties of habitat patches predict presence of and interactions among wild forked fungus beetles (Bolitotherus cornutus). B. cornutus use shelf-like fruiting bodies of wood decaying fungi (brackets) as social arenas, courtship and mating sites, oviposition locations, and food sources. Brackets on a single log vary in size and condition and represent a dynamic resource as individual brackets decay over …

Native Seed Scoop, 2024 Summer Edition, University Of Northern Iowa. Tallgrass Prairie Center.

Native Seed Scoop

Contents:

--- Upcoming Events
--- Spring Meeting Recaps
--- Native Seed Partnerships
--- Update from the Northeast Seed Network
--- Forming a Midwest Native Seed Network
--- Farm Bill Progress
--- TPC Plant Materials Updates
--- New Species in Propagation
--- 2023-24 Student Research Presentations

Finding The Safe Planting Window For Blackspot, Department Of Primary Industries And Regional Development, Western Australia

Grains and other field crops factsheets

The Blackspot Manager disease risk forecaster model is an effective tool to help identify the best balance between early sowing and potential yield loss from blackspot. Blackspot can lead to significant crop losses. Field peas become infected when windborne spores are released from fruiting bodies on infected stubble. The timing of spore release is generally early in autumn, depending on summer and autumn rain events.

Ocular Gene Transfer In The Spotlight: Implications Of Newspaper Content For Clinical Communications, Shelly Benjaminy, Tania M. Bubela

Office of the Provost

Background: Ocular gene transfer clinical trials are raising hopes for blindness treatments and attracting media attention. News media provide an accessible health information source for patients and the public, but are often criticized for overemphasizing benefits and underplaying risks of novel biomedical interventions. Overly optimistic portrayals of unproven interventions may influence public and patient expectations; the latter may cause patients to downplay risks and over-emphasize benefits, with implications for informed consent for clinical trials. We analyze the news media communications landscape about ocular gene transfer and make recommendations for improving communications between clinicians and potential trial participants in light of …

Expanding Time Covered For Medical Nutrition Therapy: A Need For Clear Reporting On The Intensity Of Nutrition Interventions, Rosa K. Hand

Faculty Scholarship

Medical Nutrition Therapy (MNT) is an evidence-based health care service that helps people improve their food and nutrition habits to positively influence health outcomes and quality of life, and is part of a suite of complementary interventions that can be implemented for effective disease prevention and management. However, the dose (ie, length and number of sessions) of MNT that is covered by health care payers in outpatient settings is highly variable and may not be adequate to achieve the desired clinical outcomes and cost savings. Interest in improving access to adequate doses of MNT provided by registered dietitian nutritionists (RDNs), …

A Timely Death Of The Tapetum Underlies More Floret1 (Mof1) Regulation Of Male Fertility In Rice, Janlo M. Robil

Biology Faculty Publications

No abstract provided.

Scientific Note: An Incursion Of The Widely-Cultivated Katsura (Cercidiphyllum Japonicum, Cercidiphyllaceae) In Pennsylvania, Kayleigh R. Long, Melody P. Sain, Elizabeth H. Williams, Christopher T. Martine

Faculty Journal Articles

Cercidiphyllum japonicum (katsura) is a dioecious tree native to China and Japan. Although imperiled in parts of its natural distribution, the species has become quite common as a cultivated tree in temperate North America. The species is noted as occasionally escaping cultivation in the eastern United States, but few records of established incursions (and the conditions under which they might recruit) exist in the literature. We here report an incursion of C. japonicum in central Pennsylvania, along with notes on seedling recruitment on the Bucknell University campus.

Forage News [2024-07], University Of Kentucky

Forage News

No abstract provided.

Growing South Dakota (Summer 2024), College Of Agriculture, Food And Environmental Sciences

Growing South Dakota (Publication of the College of Agriculture, Food and Environmental Sciences)

[Page] 2 Hayengas endow department head of animal science
[Page] 4 Reese named Klingbeil Endowed Educator
[Page] 5 SDSU Rodeo at Nationals
[Page] 6 Nwadike leading Department of Dairy and Food Science
[Page] 8 Hansen serving as 2024 Hobo Day Grand Pooba
[Page] 10 The scoop on the Davis Dairy Plant
[Page] 14 Research shows value in change
[Page] 16 Legacy of 'Yellow Ore, Yellow Hair, Yellow Pine'
[Page] 20 SDSU beef team grows
[Page] 22 SDSU Extension supporting local foods movement
[Page] 24 Bolstering rural child care needs
[Page] 26 Feeding kids great food
[Page] 27 Education Abroad takes …

Exploring The Functional Significance Of A Yap1 Missense Variant Of Uncertain Significance In Caenorhabditis Elegans, Nathan Jones

Theses

Polycystic ovary syndrome (PCOS) is a complex disorder with various implications, such as polycystic ovaries, visceral obesity, and increased risk of cancer. YAP1 was recently identified as a gene of interest in the development of PCOS. Researchers have established that single nucleotide variants in YAP1 are likely to play a role in PCOS development. This project aims to provide insight into the potential impact of a YAP1 variant of uncertain significance (VUS). Studies in C. elegans have established yap-1 as a nematode ortholog for human YAP1. A YAP1 VUS was identified through ClinVar, YAP1 c.1015A>G (p.Asn339Asp). Evolutionary conservation …

Effects Of Vitis Vinifera L. Seed Extract On Short-Term Memory Of Amyloid-Beta-Mediated Neurodegeneration In Transgenic Caenorhabditis Elegans, Elise Patrick

Theses

Alzheimer's disease (AD) is a neurodegenerative condition that is a common cause of dementia and a growing concern worldwide with no effective treatment or cure. Two pathological AD hallmarks include buildup of amyloid beta (Aβ) plaques and neurofibrillary tangles in the brain. Recent attention has turned to exploring natural products and compounds for AD symptom relief and treatment. Vitis vinifera grape seed extract (GSE) contains many beneficial substances. GSE has been tested in several animal models and has shown to improve memory and is even being examined in an AD treatment human clinical trial. In this study, the aim was …