Life Sciences Commons^™

Bat Humoral Immunity And Its Role In Viral Pathogenesis, Transmission, And Zoonosis, Anne A. Roffler, Daniel P. Maurer, Tamika J. Lunn, Tarja Sironen, Kristian M. Forbes, Aaron G. Schmidt

Biological Sciences Faculty Publications and Presentations

Bats harbor viruses that can cause severe disease and death in humans including filoviruses (e.g., Ebola virus), henipaviruses (e.g., Hendra virus), and coronaviruses (e.g., SARS-CoV). Bats often tolerate these viruses without noticeable adverse immunological effects or succumbing to disease. Previous studies have largely focused on the role of the bat’s innate immune response to control viral pathogenesis, but little is known about bat adaptive immunity. A key component of adaptive immunity is the humoral response, comprised of antibodies that can specifically recognize viral antigens with high affinity. The antibody genes within the 1,400 known bat species are highly diverse, and …

A Robust Genome Assembly With Transcriptomic Data From The Striped Bark Scorpion, Centruroides Vittatus, Tsunemi Yamashita, Douglas D. Rhoads, Jeff Pummill

Biological Sciences Faculty Publications and Presentations

Scorpions, a seemingly primitive, stinging arthropod taxa, are known to exhibit marked diversity in their venom components. These venoms are known for their human pathology, but they are also important as models for therapeutic and drug development applications. In this study, we report a high-quality genome assembly and annotation of the striped bark scorpion, Centruroides vittatus, created with several shotgun libraries. The final assembly is 760 Mb in size, with a BUSCO score of 97.8%, a 30.85% GC, and an N50 of 2.35 Mb. We estimated 36,189 proteins with 37.32% assigned to Gene Ontology (GO) terms in our GO …

States Of Matter, Todd Sformo

Journal of Humanistic Mathematics

This is a non-fiction essay overtly about three methods used in overwintering physiology, set in the context of my first learning them, along with associated thoughts and ideas as I began working on my PhD. The mathematics shows up mainly in the final section of the essay whose subtitle plays on a poem by Wallace Stevens called “Anecdote of the Jar”. This section is fable-like in its explanation of protein purification and begins with an impossible statement that is slowly adjusted to make sense by words and math.

Information About Honey Fraud: Implications Of Information Choice For Consumer Behavior, Christopher R. Gustafson

Cornhusker Economics

The study highlights that standard research practice—exposing participants to information—may not capture what will happen outside of the lab when people have a choice about what to read, view, or do with their time. While we found that having participants read about honey fraud significantly shifted their willingness to pay for local and domestic versus imported honey, we did not find those changes when people were able to select a text to read.

The implications of these findings extend beyond the issue of honey fraud to broader contexts of food safety, nutrition, and production techniques. While people have preferences for …

Adaptative Survival Of Aspergillus Fumigatus To Echinocandins Arises From Cell Wall Remodeling Beyond Β−1,3-Glucan Synthesis Inhibition, Malitha C. Dickwella Widanage, Isha Gautam, Daipayan Sarkar, Frederic Mentink-Vigier, Josh V. Vermaas, Shi You Ding, Andrew S. Lipton, Thierry Fontaine, Jean Paul Latgé, Ping Wang, Tuo Wang

School of Graduate Studies Faculty Publications

Antifungal echinocandins inhibit the biosynthesis of β−1,3-glucan, a major and essential polysaccharide component of the fungal cell wall. However, the efficacy of echinocandins against the pathogen Aspergillus fumigatus is limited. Here, we use solid-state nuclear magnetic resonance (ssNMR) and other techniques to show that echinocandins induce dynamic changes in the assembly of mobile and rigid polymers within the A. fumigatus cell wall. The reduction of β−1,3-glucan induced by echinocandins is accompanied by a concurrent increase in levels of chitin, chitosan, and highly polymorphic α−1,3-glucans, whose physical association with chitin maintains cell wall integrity and modulates water permeability. The rearrangement of …

Online Media Sentiment Analysis For Us Oysters, Taylor L. Bradford, Kwamena Quagrainie

Department of Agricultural Economics Faculty Publications

Sentiment analysis, a form of data analytics, utilises information from online discussions, reviews, and social media posts to assess consumer sentiments. This study utilised data collected from social media using online listening procedures to assess online sentiments on oysters from January 2019 through December 2022. The analysis utilises machine learning algorithms to extract consumer sentiments, opinions, and demands from online chatter from different online domains. The online sentiments are determined as positive, negative, or neutral based on their word choice, tone, and context. The information provided gives insights into perception, which is valuable information for oyster producers, seafood industry stakeholders, …

Molecular Insights Into Propylthiouracil As A Thyroid Peroxidase Inhibitor: A Computational Study Approach, Dwi Anita Suryandari, Luluk Yunaini, Hadi Sunaryo, Khaerunissa Anbar Istiadi, Irandi Putra Pratomo

Indonesian Journal of Medical Chemistry and Bioinformatics

Thyroid peroxidase (TPO) is a crucial enzyme in the biosynthesis of thyroid hormones, catalyzing the iodination of tyrosine residues in thyroglobulin and the coupling of iodotyrosines to form thyroxine (T4) and triiodothyronine (T3). Propylthiouracil (PTU) is an antithyroid drug commonly used to manage hyperthyroidism by inhibiting TPO. Understanding the molecular interactions between TPO and PTU can provide insights into the inhibitory mechanisms and guide the design of more effective antithyroid medications. Objective: This study aims to elucidate the binding interactions between TPO and PTU through molecular docking, providing a detailed understanding of how PTU inhibits TPO activity. Methods: …

Social Entrepreneurship In Sustainable Development: Strengthening The Environmental Perspective, Muhammad Iqbal Rezky, Rasto Rasto

Journal of Environmental Science and Sustainable Development

Social entrepreneurship and sustainable development are closely related concepts. Social entrepreneurship applies entrepreneurial attributes with a focus on solving major social issues. The relationship between the two demonstrates the contribution of social entrepreneurship in addressing social and environmental problems, reducing poverty, and fostering sustainable economic growth. This research employs a bibliometric approach to analyze trends and patterns in 181 relevant articles published between 2015 and 2023. Findings indicate significant growth in research between 2019 and 2021. Countries and institutions such as Spain, the United States, and Universitat de Valencia stand out in these publications. The bibliometric analysis also reveals influential …

Developing A Hyperspectral Remote Sensing-Based Algorithm To Diagnose Potato Moisture For Water-Saving Irrigation, Qiqige Suyala, Zhuoling Li, Zhenxin Zhang, Liguo Jia, Mingshou Fan, Youping Sun, Haifeng Xing

Plants, Soils, and Climate Faculty Publications

Appropriate water supply is crucial for high-yield and high-quality potato tuber production. However, potatoes are mainly planted in arid and semi-arid regions in China, where the precipitation usually cannot meet the water demand throughout the growth period. In view of the actual situation of water shortage in these areas, to monitor the water status of potato plants timely and accurately and thus precisely control the irrigation are of significance for water-saving management of potatoes. Hyperspectral remote sensing has unique advantages in diagnosing crop water stress. In this paper, the canopy spectral reflectance and plant water content were measured under five …

Draft Genome Sequences Of An Enterobacter Hormaechei And Providencia Rettgeri Isolated From The Urine Of A Male Experiencing A Catheter-Associated Urinary Tract Infection, Helen Appleberry, Michaela Brady, Samantha Webster, Alan J. Wolfe, Catherine Putonti, Alex Kula

Biology: Faculty Publications and Other Works

Catheter-associated urinary tract infections (CAUTIs) can be caused by a variety of microbes. Here, we describe the draft genome assemblies of two species—Enterobacter hormaechei and Providencia rettgeri—purified from the catheterized urine sample of a male diagnosed with a CAUTI.

Market-Based Conservation Preference In The Forest Conservation Business, Rizaldy Yudhista Yudhista, Mahawan Karuniasa, Raldi Hendro Koestoer

Journal of Environmental Science and Sustainable Development

Earth is on the verge of rising temperatures above 1.5˚ Celsius. Passing the limit of 1.5˚ Celsius is a significant risk in living on earth as it will increase the risks of natural disasters such as drought, flood, and storm. With forests capable of absorbing greenhouse gas (GHG) emissions, the need for forest conservation areas is increasing to keep the earth's temperature below 1.5˚ Celsius. The increase in demand is facing hurdles from its financial sustainability, as well as the stakeholder's paradigm, which is still seen as a forest from a direct economic perspective. Market-based initiatives (MBI) are a concept …

Exploring The Vulnerability Of Small-Scale Fisherfolks In Selected Barangays, Arlon Ponce Cadiz, Blesshelyn Guevarra Sanchez, Eden Vela Evangelista

Journal of Environmental Science and Sustainable Development

Small-scale fisherfolks contributed to the livelihood and economic aspects of the fishery sector in the region. However, they are vulnerable regarding potential risks and threats caused by various conditions. This study explored the vulnerability of fifty-two small-scale fisherfolks selected from six barangays near Laguna's Northern West Bay, Philippines. The case study design guided the data collection from multiple sources, including survey questionnaires, unstructured interviews, and document analysis for triangulation and analysis of fisherfolks' exposure, sensitivity, and adaptive capacity. Results show that there are indicators that contribute to the vulnerability of fisherfolk in terms of exposure, which involves hydrometeorological hazards, water …

The Role Of Destination Image And Risk Perception On Interest In Revisiting Disaster-Prone Coastal Destinations, Fitri Rahmafitria, Heri Puspito Diyah Setiyorini, Purna Hindayani, Andrian Ramadhan

Journal of Environmental Science and Sustainable Development

The current trend in nature tourism has led to increased tourist visits to coastal areas, including destinations prone to disasters and previously exposed to tsunamis. This research, which aims to analyze the variables influencing tourists' desire to revisit disaster-prone areas, addresses a crucial and timely topic in tourism and disaster management. The research utilized a quantitative approach through a questionnaire-based survey of domestic tourists visiting the Pangandaran Beach Area in West Java, known for its susceptibility to tsunami disasters. The study involved 307 respondents who completed questionnaires between June and July 2023. Data analysis employed Partial Least Square – Structural …

Foreword From Handling Editor - 12th Edition, Ahyahudin Sodri

Journal of Environmental Science and Sustainable Development

We are delighted to present the 12th edition of JESSD, published in July 2024. We have selected nine of the best articles for this edition that related with topic of Environmental Science and Sustainable Development.

Suitability Assessment Of Groundwater Quality For Drinking Purposes, Md. Zahidul Islam, M. G. Mostafa

Journal of Environmental Science and Sustainable Development

The groundwater status of Northwestern Bangladesh is a complex and challenging issue due to its arid and semi-arid climates, increasing population, overexploitation for domestic and irrigation purposes, lack of adequate rainfall, and limited water resources. The study aimed to assess the suitability and health risk of groundwater quality for drinking purposes. A total of one hundred groundwater samples were collected from shallow tubewells in two seasons, the monsoon (MON) and post-monsoon (POM), in northwestern Bangladesh (Ganges River basin) and analyzed using standard methods of analysis (Atomic adsorption spectrometry, UV-visible spectrometry, graphite, ion chromatography). The trends of predominant cations were Ca2+ …

Natural Dye Of Indigofera Tinctoria For Textile Industry, Nor Isnaeni Dwi Arista, Sandra Arifin Aziz, Ani Kurniawati

Journal of Environmental Science and Sustainable Development

The examination of sustainability within the textile industry necessitates an exploration of various environmental pollution issues. This study aims to tackle challenges in the synthetic dye industry by reviewing past research on textile dyeing, providing scientific insights, identifying patterns, and highlighting research gaps. It is hypothesized that the cultivation of Indigofera tinctoria with optimized NPK fertilization can significantly enhance its growth and yield, contributing to sustainable natural dye production. Using a mixed-methods approach, this study integrated bibliometric analysis of 1320 Scopus articles with field experiments. The bibliometric analysis, conducted with Vos Viewer software, identifies India and the United States as …

Cherry Powdery Mildew In Utah, Marion Murray, Christina Lilligren, Megan Kast

All Current Publications

This fact sheet provides information on powdery mildew, a common problem in commercial tart and sweet cherry orchards in Utah and throughout the western U.S. Hosts, disease biology, symptoms and signs, and management are covered.

Extraordinary Phase Transition Revealed In A Van Der Waals Antiferromagnet, Xiaoyu Guo, Wenhao Liu, Jonathan Schwartz, Suk Hyun Sung, Dechen Zhang, Aswin L N Kondusamy, Kai Sun, Hui Deng, Harald O Jeschke, Igor I Mazin, Robert Hovden, Bing Lv, Liuyan Zhao

Faculty, Staff and Student Publications

While the surface-bulk correspondence has been ubiquitously shown in topological phases, the relationship between surface and bulk in Landau-like phases is much less explored. Theoretical investigations since 1970s for semi-infinite systems have predicted the possibility of the surface order emerging at a higher temperature than the bulk, clearly illustrating a counterintuitive situation and greatly enriching phase transitions. But experimental realizations of this prediction remain missing. Here, we demonstrate the higher-temperature surface and lower-temperature bulk phase transitions in CrSBr, a van der Waals (vdW) layered antiferromagnet. We leverage the surface sensitivity of electric dipole second harmonic generation (SHG) to resolve surface …

Adaptation Of The Protein Misfolding Cyclic Amplification (Pmca) Technique For The Screening Of Anti-Prion Compounds, Katherine Do, Rebeca Benavente, Celso S G Catumbela, Uffaf Khan, Carlos Kramm, Rodrigo Morales

Faculty, Staff and Student Publications

Prion diseases result from the misfolding of the physiological prion protein (PrPC) to a pathogenic conformation (PrPSc). Compelling evidence indicates that prevention and/or reduction of PrPSc replication are promising therapeutic strategies against prion diseases. However, the existence of different PrPSc conformations (or strains) associated with disease represents a major problem when identifying anti-prion compounds. Efforts to identify strain-specific anti-prion molecules are limited by the lack of biologically relevant high-throughput screening platforms to interrogate compound libraries. Here, we describe adaptations to the protein misfolding cyclic amplification (PMCA) technology (able to faithfully replicate PrPSc strains) that increase its throughput to facilitate the …

A Comparison Of Tracheal Intubation Using Direct Laryngoscope And Video Laryngoscope In The Sellick And Trendelenburg Position With That Using Direct Laryngoscope In The Supine Sniffing Position: A Randomized Controlled Trial, Yun-Jeong Chae, Jung-Yoon Moon, Min-Gyu Lee, Han-Bum Joe

Faculty, Staff and Student Publications

Background: Tracheal intubation in the Sellick and Trendelenburg position (ST position) can prevent pulmonary aspiration but increase the difficulty of tracheal intubation. We compared tracheal intubation using video and direct laryngoscopy in the ST position with direct laryngoscopy in the supine sniffing position to evaluate the overall intubation performance. Methods: One hundred and twenty patients were randomly assigned to three groups: direct laryngoscope in the supine sniffing position (control), direct laryngoscope in the ST position (ST direct), and video laryngoscope in the ST position (ST video). The primary outcome was the intubation time; secondary outcomes included the first …

Phase Ii Study Of Talazoparib In Advanced Cancers With Brca1/2, Dna Repair, And Pten Alterations, Sarina A Piha-Paul, Chieh Tseng, Cheuk Hong Leung, Ying Yuan, Daniel D Karp, David Hong, Aung Naing, Jordi Rodon, Milind Javle, Jaffer A Ajani, Kanwal P Raghav, Neeta Somaiah, Gordon B Mills, Apostolia M Tsimberidou, Xiaofeng Zheng, Ken Chen, Funda Meric-Bernstam

Faculty, Staff and Student Publications

Cancer cells with BRCA1/2 deficiencies are sensitive to poly (ADP-ribose) polymerase (PARP) inhibitors. We evaluated the efficacy of talazoparib in DNA-Damage Repair (DDR)-altered patients. In this phase II trial, patients were enrolled onto one of four cohorts based on molecular alterations: (1) somatic BRCA1/2, (2) other homologous recombination repair pathway, (3) PTEN and (4) germline BRCA1/2. The primary endpoint was a clinical benefit rate (CBR): complete response, partial response or stable disease ≥24 weeks. 79 patients with a median of 4 lines of therapy were enrolled. CBR for cohorts 1-4 were: 32.5%, 19.7%, 9.4% and 30.6%, respectively. PTEN mutations correlated …

Phase Ii Study Of Talazoparib In Advanced Cancers With Brca1/2, Dna Repair, And Pten Alterations, Sarina A Piha-Paul, Chieh Tseng, Cheuk Hong Leung, Ying Yuan, Daniel D Karp, David Hong, Aung Naing, Jordi Rodon, Milind Javle, Jaffer A Ajani, Kanwal P Raghav, Neeta Somaiah, Gordon B Mills, Apostolia M Tsimberidou, Xiaofeng Zheng, Ken Chen, Funda Meric-Bernstam

Faculty, Staff and Student Publications

Cancer cells with BRCA1/2 deficiencies are sensitive to poly (ADP-ribose) polymerase (PARP) inhibitors. We evaluated the efficacy of talazoparib in DNA-Damage Repair (DDR)-altered patients. In this phase II trial, patients were enrolled onto one of four cohorts based on molecular alterations: (1) somatic BRCA1/2, (2) other homologous recombination repair pathway, (3) PTEN and (4) germline BRCA1/2. The primary endpoint was a clinical benefit rate (CBR): complete response, partial response or stable disease ≥24 weeks. 79 patients with a median of 4 lines of therapy were enrolled. CBR for cohorts 1-4 were: 32.5%, 19.7%, 9.4% and 30.6%, respectively. PTEN mutations correlated …

Computational Drug Repositioning And 3d Skin-Like Tissues Identify Anti-Fibrotic Targets For Systemic Sclerosis (Ssc), Dillon Popovich

Dartmouth College Ph.D Dissertations

Systemic Sclerosis (SSc) is a rare autoimmune disease characterized by dermal and internal organ fibrosis, including heart, lungs, and gastrointestinal tract, and autoantibody formation. Although disease etiology is currently unknown, like other autoimmune diseases, SSc likely develops due to environmental factor exposure in genetically susceptible individuals. Fibrotic diseases are notoriously difficult to treat. Coupled with the autoimmune aspect, SSc is difficult to study scientifically due to the lack of complex disease models that can recapitulate the immune-fibrotic axis of the disease. Due to this, there are only two FDA approved medical treatments for SSc approved for symptomatic treatment of SSc …

Influence Of Ethanol Concentration On The Extraction Of Cannabinoid And Volatile Compounds For Dry-Hemped Beer, Santiago Cardenas-Pinto, Jacob E. Gazaleh, Drew Budner, Shea Keene, Leena R. Dhoble, Abhisheak Sharma, Brian Pearson, Zhen Jia, Boce Zhang, Katherine A. Thompson-Witrick

Chemistry

Beer is one of the most widely consumed beverages in the world. Since the legalization of low-delta-9-tetrahydrocannabinol (THC) (< 0.03%) Cannabis sativa in the United States, this controversial plant is being looked upon as a potential flavor additive for use in beer. Cannabis sativa shares similar aromatic and flavor characteristics to that of hops (Humulus lupulus). This study was designed to determine the influence ethanol concentration has on the cannabinoid and volatile compounds found in beer. Three experimental beers with varying ethanol (3, 6, and 9% ABV) concentrations were used for this experiment. Using dry-hopping practices and dosing from commercial brewing techniques, hemp was placed in the beer for five days at 25 °C. Cannabinoids and volatile compounds were analyzed following the completion of the dry-hemping process. Statistical differences were observed only for the cannabinoid, tetrahydrocannabinolic acid (THCA), while, no other individual cannabinoid or the summation of the total cannabinoids were statistically different. Volatile compounds were analyzed using gas chromatography–mass spectrometry (GC-MS). Statistical differences were observed between the monoterpenes and the sesquiterpenes volatile compound groups. In summary, ethanol concentration appears to have no impact on the extraction efficiency of cannabinoids but does appear to influence volatile compounds when hemp is added to beer through the dry-hemping process.

Sullivan, Frank Victor, Collection, 1924-2005, Special Collections, Leonard H. Axe Library

Finding Aids

This collection contains materials from the life and projects of Dr. Frank “Vic” Victor Sullivan. They document contributions to: the Sperry Galligher Audubon collection of documents; reports on the planning and construction of the Kansas Technology Center at Pittsburg State University; slides of university trips and family.

Differential Effect Of An Evolving Amyloid And Tau Pathology On Brain Phospholipids And Bioactive Lipid Mediators In Rat Models Of Alzheimer-Like Pathology, Sonia Do Carmo, Marie Audrey I. Kautzmann, Surjyadipta Bhattacharjee, Bokkyoo Jun, Carolyn Steinberg, Joshua T. Emmerson, Janice C. Malcolm, Quentin Bonomo, Nicolas G. Bazan, A. Claudio Cuello

School of Graduate Studies Faculty Publications

Background: Brain inflammation contributes significantly to the pathophysiology of Alzheimer’s disease, and it is manifested by glial cell activation, increased production of cytokines/chemokines, and a shift in lipid mediators from a pro-homeostatic to a pro-inflammatory profile. However, whether the production of bioactive lipid mediators is affected at earlier stages, prior to the deposition of Aβ plaques and tau hyperphosphorylation, is unknown. The differential contribution of an evolving amyloid and tau pathology on the composition and abundance of membrane phospholipids and bioactive lipid mediators also remains unresolved. Methods: In this study, we examined the cortical levels of DHA- and AA-derived bioactive …

Adhesion G Protein-Coupled Receptor Latrophilin 1 (Adgrl1): A Novel Regulator Of Glucose And Energy Homeostasis., Kavaljit H Chhabra

Pharmacology and Nutritional Sciences Faculty Publications

No abstract provided.

Oregon State Rank Assessment For Rough Popcorn Flower (Plagiobothrys Hirtus), Nora Dunkirk

Institute for Natural Resources Publications

Oregon state conservation status assessment for rough popcorn flower (Plagiobothrys hirtus) using NatureServe methodology, 2024.

Oregon State Rank Assessment For Meadow Lomatium (Lomatium Pastorale), Nora Dunkirk

Institute for Natural Resources Publications

Oregon state conservation status assessment for meadow lomatium (Lomatium pastorale) using NatureServe methodology, 2024.

Impacts Of Managed Honeybee Apiaries On Native Bee Populations, Trapping Efficiencies Of Bee Sampling Methods, And Drone Based Floral Cover Analysis In High Elevation Tall Forb Communities In Central Utah, Nicholas Val Anderson

Theses and Dissertations

This dissertation investigates the impact of honeybee introductions on native bee populations, evaluates the efficiency of traditional bee sampling and monitoring methods, and explores the use of drone technology for assessing floral resources on federal lands in the United States. Federal lands, managed for multiple uses, present a valuable opportunity for the summer pasturing of honeybees. These lands produce vast floral resources and are largely free from pesticides and other pollutants that could weaken honeybee populations. The potential use of this resource is significant given the economic and agricultural concerns presented by declining pollinator trends and Colony Collapse Disorder (CCD). …