Life Sciences Commons^™

Exploring Lower Extremity Kinematics In Adolescent Baseball Players: Inside Vs. Outside Pitches From A Tee Stand, Alyssa Gabrielle Moreno

Open Access Theses & Dissertations

No abstract provided.

The Additive Effect Of Neuromuscular Electrical Stimulation On Resistance Training Induced Adaptations In Glycemic Control, Muscle Mass And Muscular Strength, Gabriel Narvaez

Open Access Theses & Dissertations

Background: Most adults do not reach the physical activity guidelines set by ACSM (>75%). Resistance training is well known to improve muscle mass, strength, and glycemic control. Neuromuscular electrical stimulation (NMES) is a mode of inducing involuntary muscle contractions. Previously, we have shown neuromuscular electrical stimulation is able to improve glycemic control. However, the effects of superimposing NMES while resistance training on glycemic control, substrate utilization and resting energy expenditure (REE) is unknown. Purpose: To investigate the effects of 8 weeks of superimposed NMES on resistance training compared to resistance training for glycemic control, substrate utilization, REE, muscle mass …

Ecological, Climatic, And Geomorphic Controls Of The Transport And Fate Of Co2 In Coastal Arctic Aquatic Ecosystems, Alina Spera

Open Access Theses & Dissertations

Due to the ecological and physical responses of arctic tundra to warming, organic carbon (C) stored in frozen permafrost soils is increasingly at risk of mineralization and export to aquatic systems, the coast, and atmosphere. Although many coastal aquatic systems in the Arctic are likely net sources of CO2 to the atmosphere, little is known about the drivers of inorganic C flux and how these systems contribute to regional C budgets. This dissertation addresses several lapses in our understanding of coastal inorganic C dynamics in arctic Alaska via three data chapters. In chapter 2, I examine seasonal and regional variability …

Consumer Willingness To Pay For Food Products Displaying A Black-Owned Production Label, Logan Gage Moss

Graduate Theses and Dissertations

Black and African Americans have faced historic underrepresentation in the agri-food system (Horst & Marion, 2019). Systemic inequities have hindered food entrepreneurs and economic growth within this community. Recent diversity, equity, and inclusion (DEI) initiatives highlight societal concerns about these imbalances (Darity, 2024). Some consumers aim to address this underrepresentation by purchasing products from Black entrepreneurs, but this requires effective communication, which can increase marketing expenses and risks for producers. However, highlighting Black-owned food products may enhance outcomes for this marginalized community. Credence attributes like Black ownership cannot be evaluated even after consumption, unlike traits such as taste and quality. …

Cancer Heterogeneity And Mitochondrial-Targeted Therapies In Cancer Cachexia, Francielly Morena Clark

Graduate Theses and Dissertations

Cancer Cachexia (CC) is a multifactorial and complex syndrome affecting up to 80% of cancer patients and contributing to approximately 40% of cancer-related deaths. Given its relationship with patients' quality of life and prognosis, there has been increasing emphasis on understanding the underlying mechanisms of CC using pre-clinical models. However, the mechanisms of cachexia vary depending on several factors, including tumor type, model, and biological variables such as sex. RNA-sequencing technology is a crucial tool for investigating CC heterogeneity, enabling the analysis of the transcriptome across different models, conditions, and sexes using publicly available data. Aim 1 of this dissertation …

Alternative Methods For Finishing Beef Cattle: Effects On Performance, Carcass Quality, And Meat Characteristics, Michelle Johnson

Graduate Theses and Dissertations

The objective of these studies was to evaluate the effects of alternative finishing methods on the live performance, carcass quality, and meat characteristics of beef steers. In study 1, treatments consisted of a conventional feedlot finishing diet with roughage included in the ration (FDLT); a high starch diet fed at 2-2.25% of BW with ad libitum access to bermudagrass pastures (STCH); or a high by-product diet fed at 2-2.25% of BW with ad libitum access to bermudagrass pastures (BYPD). Steers were fed their respective diets once daily and weighed every 28 days until deemed finished. Cattle were then transported and …

Synergistic Effects Of Novel Penicillin-Binding Protein 1a Amino Acid Substitutions Contribute To High-Level Amoxicillin Resistance Of Helicobacter Pylori, Alain Cimuanga-Mukanya, Evariste Tshibangu-Kabamba, Patrick De Jesus Ngoma Kisoko, Fabien Mbaya Tshibangu, Antoine Tshimpi Wola, Pascal Tshiamala Kashala, Dieudonné Mumba Ngoyi, Steve Ahuka-Mundeke, Gunturu Revathi, Ghislain Disashi-Tumba

Pathology, East Africa

The growing resistance to amoxicillin (AMX)—one of the main antibiotics used in Helicobacter pylori eradication therapy—is an increasing health concern. Several mutations of penicillin-binding protein 1A (PBP1A) are suspected of causing AMX resistance; however, only a limited set of these mutations have been experimentally explored. This study aimed to investigate four PBP1A mutations (i.e., T558S, N562H, T593A, and G595S) carried by strain KIN76, a high-level AMX-resistant clinical H. pylori isolate with an AMX minimal inhibition concentration (MIC) of 2 µg/mL. We transformed a recipient strain 26695 with the DNA containing one to four mutation allele combinations of the pbp1 gene …

Querymate: A Custom Llm Powered By Llamacpp, Pegah Khosravi

Open Educational Resources

No abstract provided.

Understanding The Role Of The Microbiome In Infectious Disease, Developing Surveillance Tools, And Engineering Direct Fed Microbials To Improve Animal Health, Alison Clare (Bartenslager) Neujahr

Dissertations and Doctoral Documents, University of Nebraska-Lincoln, 2023–

With the ever-increasing demand for animal protein and the continual need for the assurance of proper animal welfare, investigations of preventative strategies for diseases is greatly needed. Specifically in the cattle industry, infectious bovine keratoconjunctivitis (IBK), commonly known as pinkeye, causes a large economic loss to the producer. However, effective mitigation strategies are lacking. Partly, this is due to the lack of studies investigating the ocular microbiome. Therefore, studies investigating the bovine ocular microbiome are greatly needed to better understand IBK disease etiology. To this end, we investigated the changes in the ocular microbiome in animals before, during and after …

The Impact Of Ectopic Expression Of A Plant Elicitor Peptide In Bacillus Subtilis On Nematode Resistance In Soybean Through Seed Treatment, Abeer Alnasrawi

Graduate Theses and Dissertations

Soybean (Glycine max) is the most beneficial legume crop because it is a source of protein as well as oil for humans and livestock. Soybean is the second most planted crop in the United States following corn and it is also the fourth planted crop worldwide. However, the soybean cyst nematode (Heterodera glycines, SCN) is the most damaging pest of soybean in the United States, accounting for more than twice as much yield loss as the following cause of yield loss in soybean. Therefore, there is a pressing need to develop alternative management strategies to control SCN infection in soybeans. …

Is All Genetically Modified Maize The Same: South African Consumer Acceptance Of Water Efficient Maize For Africa (Wema), Molly Claire English

Graduate Theses and Dissertations

The Water Efficient Maize for Africa (WEMA) partnership was launched in March 2008 to help maize producers manage drought risk by developing and deploying genetically modified (GM) maize varieties that yield 24 to 35 percent more grain under moderate drought conditions than currently available varieties across Southern Africa. Although the World Bank classifies South Africa as an upper-middle-income country, food insecurity is an ongoing concern that worsens during drought. During the drought of 2014/2015, the price of white maize more than doubled, resulting in 22% of households experiencing food insecurity. While GM maize (herbicide tolerant, Bt, and stacked) is widely …

Unraveling The Complex Dynamics Of Cardiac Fibrosis: Ccn1 As A Novel Regulator Of Scar Collagen Architecture And Structural Integrity In Myocardial Infarction., Annalara Garland Fischer

Electronic Theses and Dissertations

Expansion of the extracellular matrix (ECM), known as fibrosis, accompanies nearly all forms of cardiac disease; however, its most significant and complex manifestations arise following a myocardial infarction (MI). This process, principally led by fibroblasts, constitutes a necessary and adaptive response acutely to fill the void from cardiomyocyte necrosis following ischemic injury due to the heart’s lack of regenerative capacity. This acute response never fully resolves and contributes to ongoing collagen accumulation in non-infarcted regions, leading to diminished ventricular compliance, ongoing myocyte loss, and attrition in function—culminating in heart failure. Further, recent research demonstrates that concomitant with progressive increases in …

Use Of Herbicides Coated Onto Fertilizer And Applied Over-The-Top Of Cotton, Summer Linn

Graduate Theses and Dissertations

Cotton (Gossypium hirsutum L.) production faces numerous challenges, many related to weed management. A herbicide application method that focuses on combing resources that producers already have access to, such as herbicide-coated fertilizers, could be a practical approach for addressing late-season control of Palmer amaranth (Amaranthus palmeri S. Wats) and other problematic weed species. Two main factors would potentially impact the efficiency of utilizing this method: cotton tolerance to the application and weed control provided by the herbicide-coated fertilizers. Some considerations could affect the efficacy of these applications, such as when the treatments are applied and when they are activated by …

The Effects Of Cover Crop Adoption On Yield Distributions Under Extreme Drought, Emory Johnson

Graduate Theses and Dissertations

Increased frequency and severity of extreme weather events due to climate change negatively impact agriculture output. Of particular concern is the adverse impact of droughts on corn and soybean yields, as these crops represent a significant portion of cash crop receipts in the United States. Cover crops are one practice that has gained attention due to their agronomic benefits and their potential to reduce downside production risk for producers. This study focuses on the impact of cover crop adoption on corn and soybean yields during drought conditions. We use cover crop adoption data from the Operational Tillage Information System, RMA …

Evaluation Of A Diflufenican:Metribuzin:Flufenacet Premixture For Soybean Tolerance And Weed Control, Matthew Coleman Woolard

Graduate Theses and Dissertations

Palmer amaranth [Amaranthus palmeri (S.) Wats.] and waterhemp [Amaranthus tuberculatus (Moq.) Sauer] ranks among the most troublesome weeds of soybean [Glycine max (L.) Merr.], having evolved resistance to multiple herbicide sites of action. Bayer CropScience has announced its intentions to launch Convintro™ brand herbicides, one being a three-way premixture for use preplant until 3 d after planting in soybean. The premixture will include diflufenican (WSSA Group 12), metribuzin (WSSA Group 5), and flufenacet (WSSA Group 15) (DFF-containing premixture), adding a new site of action for use in soybean throughout the United States. In 2022 and 2023, field trials were conducted …

Understanding The Livelihood Diversification Of Arkansas Women Involved In Agricultural Production, Oluwatoyin Elizabeth Abati

Graduate Theses and Dissertations

Agriculture as a livelihood activity entails significant risks and uncertainties, which expose agricultural households to a low standard of living, poverty, and a lowering of their food security status. Women's responsibilities in agriculture are expanding and becoming more critical, and farm women are now broadening their duties to include roles off-farm. More research is needed in Arkansas about agricultural women's roles, challenges, and essential job characteristics. Using a quantitative survey, this research aimed to provide a resource on how women involved in agricultural production diversify their livelihoods. Participants were asked to describe their livelihood diversification by identifying their activities on …

Cobblestone Farms, Fayetteville: A Study Of A Non-Profit Teaching Farm’S Volunteer Management Programs, Ariel Scholten

Graduate Theses and Dissertations

Non-profit teaching farms (NPTFs) represent a unique intersection of mission-driven non-profits, agricultural education, and sustainable food production. Despite their growing presence, research on NPTFs, particularly regarding volunteer management, remains limited. This thesis examines volunteer management practices at Cobblestone Farms (CF), a prominent NPTF in Northwest Arkansas, focusing on its strategies to engage and retain volunteers. Through qualitative methods including semi-structured interviews with staff and volunteers, the study identifies, describes, and evaluates key components of CF's volunteer management program. Major findings reveal that CF leverages digital media, online platforms like Give Pulse, and strategic partnerships to recruit and maintain volunteers. The …

Modeling Enterococcus Cecorum Horizontal Transmission To Investigate The Impact Of Perinatal Exposure On Extraintestinal Colonization, Disease Presentation, And Performance In Young Broiler Chickens, James Y. Higuita Valle

Graduate Theses and Dissertations

Enterococcus cecorum (EC) has primarily been associated with osteomyelitis and lameness in older chickens. The recent emergence of pathogenic EC causing morbidity and mortality in young broiler chicken flocks requires further investigation. The purpose of this thesis was to develop a model to simulate horizontal transmission of virulent EC during the hatching phase in small scale hatchet cabinets. The model will be used to investigate novel pre- and post-hatch strategies to mitigate EC infections in young broiler chickens. The current thesis contains four chapters. Chapter I includes the thesis introduction. A literature review focusing on EC-associated disease in chickens, with …

L-Arabinose Induced Overexpression For Crystallographic Analysis Of The Spoiie Protein From Clostridioides Difficile, Danielle M. Maynard

Graduate Theses and Dissertations

The SpoIIE protein plays a crucial role in the sporulation process of Clostridioides difficile, a pathogen responsible for severe gastrointestinal diseases. Understanding the structural and functional aspects of SpoIIE is pivotal for deciphering its role in sporulation and exploring its potential as a therapeutic target. This study investigates the impact of varying concentrations of L-arabinose on the overexpression of SpoIIE in C. difficile, aiming to optimize protein yield and purity for subsequent crystallization and structural determination via X-ray crystallography. Using a recombinant expression system in Escherichia coli, different concentrations of L-arabinose were employed to induce SpoIIE overexpression. Protein purification was …

Phylogenomic Analyses Of Three Distinct Lineages Uniting Staphylococcus Cohnii Snd Staphylococcus Urealyticus From Diverse Hosts, L. Caroline House, Amer Hasan, Andi Asnayanti, Adnan A. Alrubaye, Jeff Pummill, Douglas Rhoads

Poultry Science Faculty Publications and Presentations

We sequenced and assembled genomes for 17 isolates of Staphylococcus cohnii isolated from osteomyelitis lesions in young broilers from two separate experiments where we induced lameness using a hybrid wire-litter flooring system. Whole genome comparisons using three different methods support a close relationship of genomes from both S. cohnii and Staphylococcus urealyticus. The data support three different lineages, which we designated as Lineage 1, Lineage 2, and Lineage 3, uniting these two species within an evolving complex. We present evidence for horizontal transfer between lineages of genomic regions from 50–440 kbp. The transfer of a 186 kbp region from …

Exploring Equity In Introductory Biology Genetics Education, Sandy G. Phillips-Long

All Dissertations

The dissertation “Exploring Equity in Introductory Biology Genetics Education” delved into the critical examination of equity within undergraduate genetics education. Chapter One outlined the background, significance, research framework, and manuscripts included in this study. Chapter Two was a scoping review that provided an overview of the current pedagogical approaches in undergraduate genetics education. It identified six active learning pedagogies: Course-based Undergraduate Research Experience (CURE); group work; case-based learning; inquiry-based learning; Virtual Reality (VR); and Consider, Read, Elucidate the hypothesis, Analyze and interpret the data, and Think of the next Experiment (CREATE). Chapter Three was a systematic literature review investigating pedagogical …

Pelvic Sucker Form And Function In Waterfall Climbing Gobies: Variation In Morphology And Adhesive Performance Can Inspire Biomimetic Innovation, Amanda Palecek Mcclung

All Dissertations

Adhesive systems have evolved in many animal lineages and have appeared multiple times among the fishes. Bioadhesion in the gobies, a group found around the world, plays a role in both station-holding and even climbing. Among the Hawaiian streams, we find four species of amphidromous gobies which must face predators as juveniles and climb streams up to hundreds of feet tall to reach adult habitats. These gobies exhibit a range of climbing and adhesive abilities that result in an elevation-dependent species stratification, in which increasingly proficient climbing species are found in streams at increasingly higher elevations. This group is therefore …

Vision-Based Autonomy Stacks For Farm Tractors And Intelligent Spraying Systems In Orchards, Shengli Xu

All Dissertations

Autonomous tractors equipped with intelligent sprayers have become a pivotal aspect of smart farming (SF), marking a transformative shift in traditional agricultural practices and holding the potential to revolutionize the farming industry. With 2,453,620 fruit-bearing acres in the United States as of 2022, there is a pressing need for the implementation of autonomous systems for farm tractors and intelligent spraying systems in orchards. These advancements can significantly reduce labor costs, address labor shortages, and minimize spray loss. Furthermore, to enhance profitability and productivity, it is essential to develop low-cost yet effective vision-based autonomy systems that can operate efficiently across various …

Effect Of Chemical Enhancers On Transdermal Delivery Of Amiloride For Management Of Resistant Hypertension, Oluwatosin Tabitha Leshaodo

Electronic Theses and Dissertations

Amiloride, a diuretic used for managing resistant hypertension, is hindered by low oral bioavailability and Gastrointestinal side effects, impacting patient compliance. This study investigates transdermal delivery as an alternative to reduce pill burden and improve adherence. Using dermatomed porcine ear skin, the research examined the passive transdermal delivery of amiloride and the effect of various chemical enhancers, including oleic acid, oleyl alcohol, tocopheryl polyethylene glycol succinate, and N-methyl-2-pyrrolidone, individually or in combination. A validated High-Performance Liquid Chromatography method, adhering to Internal Council for Harmonized guidelines (ICH), was employed for quantitative analysis. In vitro permeation studies, conducted using porcine skin and …

Automatic Uncovering Of Patient Primary Concerns In Portal Messages Using A Fusion Framework Of Pretrained Language Modelsautomatic Uncovering Of Patient Primary Concerns In Portal Messages Using A Fusion Framework Of Pretrained Language Models, Sunyang Fu, Dezhi Wu, Hongfang Liu, Ming Huang

Faculty, Staff and Student Publications

OBJECTIVES: The surge in patient portal messages (PPMs) with increasing needs and workloads for efficient PPM triage in healthcare settings has spurred the exploration of AI-driven solutions to streamline the healthcare workflow processes, ensuring timely responses to patients to satisfy their healthcare needs. However, there has been less focus on isolating and understanding patient primary concerns in PPMs-a practice which holds the potential to yield more nuanced insights and enhances the quality of healthcare delivery and patient-centered care.

MATERIALS AND METHODS: We propose a fusion framework to leverage pretrained language models (LMs) with different language advantages via a Convolution Neural …

Artificial Intelligence In Fusion Protein Three-Dimensional Structure Prediction: Review And Perspective

Faculty, Staff and Student Publications

Recent advancements in artificial intelligence (AI) have accelerated the prediction of unknown protein structures. However, accurately predicting the three-dimensional (3D) structures of fusion proteins remains a difficult task because the current AI-based protein structure predictions are focused on the WT proteins rather than on the newly fused proteins in nature. Following the central dogma of biology, fusion proteins are translated from fusion transcripts, which are made by transcribing the fusion genes between two different loci through the chromosomal rearrangements in cancer. Accurately predicting the 3D structures of fusion proteins is important for understanding the functional roles and mechanisms of action …

Patient-Centered Clinical Decision Support Challenges And Opportunities Identified From Workflow Execution Models, Nicole A Gauthreaux, James Swiger, Edwin A Lomotan, Prashila Dullabh

Faculty, Staff and Student Publications

OBJECTIVE: To use workflow execution models to highlight new considerations for patient-centered clinical decision support policies (PC CDS), processes, procedures, technology, and expertise required to support new workflows.

METHODS: To generate and refine models, we used (1) targeted literature reviews; (2) key informant interviews with 6 external PC CDS experts; (3) model refinement based on authors' experience; and (4) validation of the models by a 26-member steering committee.

RESULTS AND DISCUSSION: We identified 7 major issues that provide significant challenges and opportunities for healthcare systems, researchers, administrators, and health IT and app developers. Overcoming these challenges presents opportunities for new …

Assessing The Reproducibility Of Research Based On The Food And Drug Administration Manufacturer And User Facility Device Experience Data

Faculty, Staff and Student Publications

Objective: This article aims to assess the reproducibility of Manufacturer and User Facility Device Experience (MAUDE) data-driven studies by analyzing the data queries used in their research processes.

Methods: Studies using MAUDE data were sourced from PubMed by searching for "MAUDE" or "Manufacturer and User Facility Device Experience" in titles or abstracts. We manually chose articles with executable queries. The reproducibility of each query was assessed by replicating it in the MAUDE Application Programming Interface. The reproducibility of a query is determined by a reproducibility coefficient that ranges from 0.95 to 1.05. This coefficient is calculated by comparing the number …

Serl: Style-Embedding Representation Learning For Unsupervised Ct Images Synthesis From Unpaired Mr Images, Xiaobo Zhou

Faculty, Staff and Student Publications

Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related deaths worldwide, and the fastest-growing cause of cancer deaths in the United States. Computed tomography (CT) and magnetic resonance (MR) imaging are the key image-based examination methods for HCC patients. Patients may alternatively undergo CT and MR exams given a radiation dose of the former and the cost of the latter. Due to organ representation differences between CT and MR, it's a great challenge to detect the tumors from a time series of data consisting of both CT and MR by a single model. The annotations for these time series …

Challenges In Lncrna Biology: Views And Opinions, Ekaterina G Derevyanchuk, Tatiana P Shkurat, Jeffrey A Loeb, Ivan Martinez, Leonard Lipovich

Faculty, Staff and Student Publications

This is a mini-review capturing the views and opinions of selected participants at the 2021 IEEE BIBM 3rd Annual LncRNA Workshop, held in Dubai, UAE. The views and opinions are expressed on five broad themes related to problems in lncRNA, namely, challenges in the computational analysis of lncRNAs, lncRNAs and cancer, lncRNAs in sports, lncRNAs and COVID-19, and lncRNAs in human brain activity.