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Articles 22531 - 22560 of 255884
Full-Text Articles in Life Sciences
Effect Of Stocking Density On Growth, Biochemical Composition, And Blood Parameters In The Pacific Shortfin Eel (Anguilla Bicolor Pacifica) Elvers, Frolan A. Aya, John Carlo L. Unida, Luis Maria B. Garcia, Rowena R. Eguia Ma.
Effect Of Stocking Density On Growth, Biochemical Composition, And Blood Parameters In The Pacific Shortfin Eel (Anguilla Bicolor Pacifica) Elvers, Frolan A. Aya, John Carlo L. Unida, Luis Maria B. Garcia, Rowena R. Eguia Ma.
The Philippine Agricultural Scientist
This study examined the effect of stocking density on growth, biochemical composition, and blood parameters of the Pacific shortfin eel Anguilla bicolor pacifica. Elvers (1.95 ± 0.14 g body weight) were randomly stocked in indoor tanks and reared over 186 d at three stocking densities (0.3, 0.6, and 0.9 kg m-3) set up in triplicates. Except for survival and biometric indices, elvers maintained at 0.3 and 0.6 kg m-3 densities exhibited higher growth and feed utilization than those held at 0.9 kg m-3. Yield increased with stocking density, which were significantly higher at 0.6 …
Boar Sperm Performance In Polystyrene Transport Cool Box Under Various Storage Conditions And Holding Times [Rsearch Note], Santiago T. Peña Jr., Bianca Therese P. Ymas, Mark Edd B. Janier, Heherson A. Luza
Boar Sperm Performance In Polystyrene Transport Cool Box Under Various Storage Conditions And Holding Times [Rsearch Note], Santiago T. Peña Jr., Bianca Therese P. Ymas, Mark Edd B. Janier, Heherson A. Luza
The Philippine Agricultural Scientist
When transporting highly valuable boar semen samples over long distances, it is crucial to ensure that boar semen is stored ideally at approximately 15 – 17°C to minimize the impact of cold shock and oxidative damage on sperm quality. This study evaluated the performance of a commercially available semen and embryo polystyrene transport cool box, BotuFLEX®, in preserving the quality of extended boar semen under different storage conditions and holding times. Boar ejaculates were extended at 1:1 or 1:3 using a commercial mid-term extender, stored in a BotuFLEX® semen cool box, and examined 24 vs. 48 h thereafter (Experiment 1; …
Draft Genome Sequence Of Ruoffia Tabacinasalis Isolated From A Bovine Nasal Swab: A Novel Member Of The Bovine Nasal Microbiota, Samantha Howe, Xiaoyuan Wei, Jasna Kovac, Jiangchao Zhao
Draft Genome Sequence Of Ruoffia Tabacinasalis Isolated From A Bovine Nasal Swab: A Novel Member Of The Bovine Nasal Microbiota, Samantha Howe, Xiaoyuan Wei, Jasna Kovac, Jiangchao Zhao
Animal Science Faculty Publications and Presentations
We report the isolation and draft genome sequence of Ruoffia tabacinasalis, a novel member of the bovine nasal microbiota. The genome, which is estimated to be 90.5% complete, is composed of one contig comprising 2,363,349 bp with a GC content of 36.66%.
Tar Vine And Its Management, Department Of Primary Industries And Regional Development, Western Australia
Tar Vine And Its Management, Department Of Primary Industries And Regional Development, Western Australia
Biosecurity factsheets
Tar vine (Boerhavia coccinea) is a common summer weed species that depletes soil moisture and nutrients, reducing the yield potential of the subsequent crop. It also acts as a green bridge for crop pests and disease.
Scale-Dependent Population Drivers Inform Avian Management In A Declining Saline Lake Ecosystem, Aimee M. Van Tatenhove, John Neill, Russell E. Norvell, Erica F. Stuber, Clark S. Rushing
Scale-Dependent Population Drivers Inform Avian Management In A Declining Saline Lake Ecosystem, Aimee M. Van Tatenhove, John Neill, Russell E. Norvell, Erica F. Stuber, Clark S. Rushing
Wildland Resources Faculty Publications
Shrinking saline lakes provide irreplaceable habitat for waterbird species globally. Disentangling the effects of wetland habitat loss from other drivers of waterbird population dynamics is critical for protecting these species in the face of unprecedented changes to saline lake ecosystems, ideally through decision-making frameworks that identify effective management options and their potential outcomes. Here, we develop a framework to assess the effects of hypothesized population drivers and identify potential future outcomes of plausible management scenarios on a saline lake-reliant waterbird species. We use 36 years of monitoring data to quantify the effects of environmental conditions on the population size of …
Testing Feed Is Vital For Feed Budgeting, Department Of Primary Industries And Regional Development, Western Australia
Testing Feed Is Vital For Feed Budgeting, Department Of Primary Industries And Regional Development, Western Australia
Animal production and livestock factsheets
A little knowledge of the nutritional value of your supplementary feeds can save you a lot of money and hassle.
In dry seasons, it is likely that farmers will need to start supplementary feeding earlier than usual. The higher requirement for supplementary feeds over dry seasons means accurate feed budgeting becomes increasingly important to minimise feed wastage, for weaner survival, and to maintain stock at the right condition score (CS) for joining.
Diamondback Moth And Its Management In Canola And Crop Weeds, Department Of Primary Industries And Regional Development, Western Australia
Diamondback Moth And Its Management In Canola And Crop Weeds, Department Of Primary Industries And Regional Development, Western Australia
Grains and other field crops factsheets
Diamondback moth larvae are a serious pest of canola, brassicas, and forage crops, and are difficult to control. The pest breeds up on summer weeds and volunteer canola plants. If there are abundant early rains and mild winters, diamondback moth larvae pose a risk to canola crops.
Spray-Topping Pastures, Department Of Primary Industries And Regional Development, Western Australia
Spray-Topping Pastures, Department Of Primary Industries And Regional Development, Western Australia
Grains and other field crops factsheets
Spray-topping or pasture topping is the application of a sub-lethal rate of herbicide when grasses are coming into head and flowering.
The aim is to reduce the production of viable seed and the seedling population in the following year. The grass is not killed by the herbicide application.
Spray-topping is normally carried out in preparation for the following season's cropping program.
Leaf Diseases And Their Management In Oats, Department Of Primary Industries And Regional Development, Western Australia
Leaf Diseases And Their Management In Oats, Department Of Primary Industries And Regional Development, Western Australia
Grains and other field crops factsheets
Leaf diseases of oats impact on grain yield and quality and reduce hay quality characteristics, such as colour and digestibility. This page outlines the symptoms, factors favouring disease risk and spread, and management.
Major leaf diseases of oats are septoria avenae blotch, stem rust, leaf rust, and barley yellow dwarf virus. Their severity changes with seasons.
Foliar Diseases And Their Management In Lupins, Department Of Primary Industries And Regional Development, Western Australia
Foliar Diseases And Their Management In Lupins, Department Of Primary Industries And Regional Development, Western Australia
Grains and other field crops factsheets
This factsheet describes symptoms and management of the major fungal and viral diseases affecting lupin foliage, stems, and pods. Several of these diseases have the capacity to cause significant losses if not managed effectively.
Inoculum can be carried in soil, seed, stubble, on green regrowth, or by insect vectors, depending on the disease. Therefore, an integrated approach to disease management is required using tactics such as crop rotation, stubble management, fungicide seed dressing, variety selection, and seed testing
Are You Planting Resistant Weeds With Your Crop Seed?, Department Of Primary Industries And Regional Development, Western Australia
Are You Planting Resistant Weeds With Your Crop Seed?, Department Of Primary Industries And Regional Development, Western Australia
Grains and other field crops factsheets
Key messages
• West Australian (WA) grain growers have significant weed seed contamination in their crop seed.
• WA growers are sowing herbicide resistant weed seed into their cropping paddocks.
• Crop hygiene (harvest, seeding, transporting) is important to minimise spread of weeds.
Harvest is well underway throughout the WA grainbelt, and growers will be harvesting grain and collecting seed for next year’s crop.
However, this crop seed can be contaminated with weed seeds and, if seed cleaning operations are only partially effective, this weed seed may be sown into paddocks with crop seed in the following season.
Russian Wheat Aphid And Its Management In Wheat And Barley, Department Of Primary Industries And Regional Development, Western Australia
Russian Wheat Aphid And Its Management In Wheat And Barley, Department Of Primary Industries And Regional Development, Western Australia
Grains and other field crops factsheets
Russian wheat aphid is found worldwide and has spread throughout all major grain growing countries. In Australia, Russian wheat aphid is present in South Australia, Victoria, New South Wales, Tasmania, and Western Australia, where it was first detected in 2020.
In Western Australia, Russian wheat aphid is found in low, medium, and high rainfall areas.
Presence of Russian wheat aphid in Western Australia is not an international trade issue and there are no trade implications for the grain industry, as bulk grain is not a host for Russian wheat aphid.
Managing Aphids And Viruses In Lupins, Department Of Primary Industries And Regional Development, Western Australia
Managing Aphids And Viruses In Lupins, Department Of Primary Industries And Regional Development, Western Australia
Grains and other field crops factsheets
Aphids reduce yields by direct feeding damage, which causes flower and pod abortion and occasionally plant death in lupins. The extent of damage varies between seasons, but losses can be severe in years that favour aphid population development.
Lupins are most vulnerable to aphids during budding and flowering, as severe feeding damage on growing tips can cause buds to drop, flowers to abort, and reduced pod set. Some lupin varieties are more susceptible to aphids than others.
Aphids transmit serious virus diseases, which reduce yields and contaminate seed stocks. Some species of aphids are more difficult to control than others.
Native Budworm Spraying Threshold, Department Of Primary Industries And Regional Development, Western Australia
Native Budworm Spraying Threshold, Department Of Primary Industries And Regional Development, Western Australia
Grains and other field crops factsheets
The number of native budworm caterpillars in a crop is the major factor determining potential economic damage from the pest. Table 1 was generated with results from department trials to provide an estimate of potential loss from native budworm damage.
Crop loss (kilograms per hectare (kg/ha)) for each caterpillar netted in 10 sweeps (or found per square metre (m2 )) is shown in Table 1. One caterpillar netted in 10 sweeps is equivalent to about 20,000 caterpillars/ha for most pulse crops, assuming an even distribution over the crop
Stem Rust And Its Management In Wheat, Department Of Primary Industries And Regional Development, Western Australia
Stem Rust And Its Management In Wheat, Department Of Primary Industries And Regional Development, Western Australia
Grains and other field crops factsheets
Stem rust (Puccinia graminis f. sp. tritici) is a foliar disease that can significantly reduce wheat yields if it occurs in early spring and is not controlled. Risk factors, management strategies (including variety choices and foliar fungicides), and yield loss from different varieties are discussed here.
In Western Australia, stem rust typically causes losses of 10 to 50% in wheat, but this can increase to 90% when it occurs in early spring and is not controlled.
Stem rust affects wheat and triticale, but barley can also be a host during summer months.Stem rust produces large, reddish-brown spore masses on both …
Therapeutics For Sickle Cell Disease Intravascular Hemolysis, Jianyao Xue, Xiang-An Li
Therapeutics For Sickle Cell Disease Intravascular Hemolysis, Jianyao Xue, Xiang-An Li
Markey Cancer Center Faculty Publications
Sickle cell disease (SCD) is a genetic disorder predominantly affecting individuals of African descent, with a significant global health burden. SCD is characterized by intravascular hemolysis, driven by the polymerization of mutated hemoglobin within red blood cells (RBCs), leading to vascular inflammation, organ damage, and heme toxicity. Clinical manifestations include acute pain crises, hemolytic anemia, and multi-organ dysfunction, imposing substantial morbidity and mortality challenges. Current therapeutic strategies mitigate these complications by increasing the concentration of RBCs with normal hemoglobin via transfusion, inducing fetal hemoglobin, restoring nitric oxide signaling, inhibiting platelet-endothelium interaction, and stabilizing hemoglobin in its oxygenated state. While hydroxyurea …
Novel Psychoplastogen Dm506 Reduces Cue-Induced Heroin-Seeking And Inhibits Tonic Gaba Currents In The Prelimbic Cortex, Kassandra Looschen, Shailesh N. Khatri, Malabika Maulik, Colin Salisbury, Alaina F. Carman, Katilyn Corriveau, Colton Smith, Dina Manetti, Maria Novella Romanelli, Hugo R. Arias, Cassandra D. Gipson, Swarup Mitra
Novel Psychoplastogen Dm506 Reduces Cue-Induced Heroin-Seeking And Inhibits Tonic Gaba Currents In The Prelimbic Cortex, Kassandra Looschen, Shailesh N. Khatri, Malabika Maulik, Colin Salisbury, Alaina F. Carman, Katilyn Corriveau, Colton Smith, Dina Manetti, Maria Novella Romanelli, Hugo R. Arias, Cassandra D. Gipson, Swarup Mitra
Markey Cancer Center Faculty Publications
Opioid use disorder is a major public health crisis that is manifested by persistent drug-seeking behavior and high relapse frequency. Most of the available treatments rely on targeting opioid receptors using small molecules that do not provide sustained symptom alleviation. Psychoplastogens are a novel class of non-opioid drugs that produce rapid and sustained effects on neuronal plasticity, intended to produce therapeutic benefits. Ibogalogs are synthetic derivatives of iboga alkaloids that lack hallucinogenic or adverse side effects. In the current study, we examine the therapeutic potential of DM506, a novel ibogalog lacking any cardiotoxic or hallucinogenic effects, in cue-induced seeking behavior …
Of Geese And Grass: Investigating Impacts Of Brant Grazing On Eeelgrass, Dakota L. Osborne
Of Geese And Grass: Investigating Impacts Of Brant Grazing On Eeelgrass, Dakota L. Osborne
Master's Theses
Grazing pressure is important in structuring plant communities, particularly in aquatic environments. Eelgrass (Zostera marina), a keystone species in estuaries across North America, is experiencing widespread population declines. As a keystone species, eelgrass provides numerous important functions, including: 1) water filtration, 2) sediment stabilization, 3) providing refuge and nursery habitat for numerous species, and 4) carbon sequestration. Benefits which could be lost if eelgrass beds continue to diminish. California has experienced some of the greatest eelgrass declines, and Morro Bay, CA experienced a 96% decrease in eelgrass from 2007 to 2017. Most studies to date have examined bottom-up …
Documenting Cooperative Extension’S Family Resource Management Impacts: Insights And Outcomes From A National Effort, Suzanne Bartholomae, D. Elizabeth Kiss, Maria Pippidis
Documenting Cooperative Extension’S Family Resource Management Impacts: Insights And Outcomes From A National Effort, Suzanne Bartholomae, D. Elizabeth Kiss, Maria Pippidis
Journal of Human Sciences and Extension
Family Resource Management (FRM) professionals of the Cooperative Extension System contribute to the financial security and well-being of individuals and families and are committed to contributing to financial literacy education scholarship and better positioning Cooperative Extension within the field of financial and consumer education. This paper presents a summary of a multi-year initiative by a team of FRM Extension professionals who build the case for creating a reporting system to document FRM impacts nationally. Initiative activities are summarized and include reviewing existing reporting systems, garnering input from FRM Extension professionals about the delivery and evaluation of FRM programs, identifying barriers …
Using Mentimeter In Online Book Clubs To Engage And Educate Extension Audiences, Nichole Huff, Miranda Bejda, Emily Dewitt, Heather Norman-Burgdolf, Melinda Mcculley
Using Mentimeter In Online Book Clubs To Engage And Educate Extension Audiences, Nichole Huff, Miranda Bejda, Emily Dewitt, Heather Norman-Burgdolf, Melinda Mcculley
Journal of Human Sciences and Extension
During the COVID-19 pandemic, Cooperative Extension professionals, like many others, were tasked with quickly adapting to accommodate limited face-to-face interactions. The pandemic necessitated that Extension educators leverage online resources to deliver tailored programming in informative and innovative ways while providing engaging, hands-on learning experiences. This article highlights two studies using Mentimeter as a tool to educate and engage Extension audiences through subsequent installments of an online book club. The presented case studies examine the processes and outcomes of a unique educational approach to Family and Consumer Sciences (FCS) in a non-traditional setting. The studies represent two distinct FCS disciplines: Family …
Preservice Agriscience Teachers’ Perception Of Inquiry-Based Learning, John Porter, Nathan W. Conner, Christopher T. Stripling
Preservice Agriscience Teachers’ Perception Of Inquiry-Based Learning, John Porter, Nathan W. Conner, Christopher T. Stripling
Journal of Human Sciences and Extension
The process of inquiry-based learning allows learners to identify a problem or develop a hypothesis, develop a process of inquiry, and report their findings (Keselman, 2003). Twenty-six preservice agriscience teachers at the University of Nebraska-Lincoln participated in focus groups to explore preservice agriscience teachers’ perceptions of developing and using science-based learning activities that use inquiry-based teaching methods. Qualitative data analysis allowed the following six themes to emerge: a) inquiry-based learning is a process, b) trainings and pre-made lessons, c) student- vs teacher-led, d) critical thinking and problem solving, e) age, skill, & prior knowledge of students, and f) time-consuming to …
Leveraging A Team Approach For Emergency Preparedness In Georgia, Virginia Brown, Maria Bowie, Pamela Turner, Aaron Golson
Leveraging A Team Approach For Emergency Preparedness In Georgia, Virginia Brown, Maria Bowie, Pamela Turner, Aaron Golson
Journal of Human Sciences and Extension
This project cultivated a foundational level of training that will grow as an integral part of the University of Georgia Cooperative Extension’s organizational commitment to provide systemic readiness in support of the emergency response. The development of four geographically dispersed, specially trained small teams within the University of Georgia Extension System built capacity for readiness, response, and recovery to natural disasters and local emergencies. These teams help facilitate a timely and skilled response to the needs of employees and stakeholders before, during, and after natural disasters and local emergency events. Specialized training continues to be provided to all team members.
Tulane Virus Persistence And Microbial Stability In 3d Food Ink Under Various Storage Conditions: A Pre- And Post-Printing Analysis, Allyson N. Hamilton, Kristen E. Gibson
Tulane Virus Persistence And Microbial Stability In 3d Food Ink Under Various Storage Conditions: A Pre- And Post-Printing Analysis, Allyson N. Hamilton, Kristen E. Gibson
Food Science Faculty Publications and Presentations
3D food printers facilitate novel customization of the physicochemical properties of food. This study aimed to investigate the impact of storage conditions on the inactivation of the human norovirus surrogate, Tulane virus (TuV), within 3D printed foods. TuV-inoculated protein cookie food ink (∽ 4 log PFU/g) was distributed into 18 3D food printer capsules (50 g each); half immediately underwent extrusion. Storage of the capsules and printed food products at 20 °C (0, 6, 12, and 24 h), 4 °C (0, 1, 3, and 5d), and − 18 °C (0, 1, 3, and 5d) was completed before analysis for TuV …
Michael Mcgraw: Profile Of The Newest Chbc Faculty Member, Danna Jaimes-Fajardo, Jeremy J. Smith, Lutishoor Salisbury
Michael Mcgraw: Profile Of The Newest Chbc Faculty Member, Danna Jaimes-Fajardo, Jeremy J. Smith, Lutishoor Salisbury
University Libraries Faculty Publications and Presentations
Presents the research profile of Michael McGraw, Assistant Professor, Chemistry and Biochemistry department. It highlights his research interests, education, and impact of his research.
Development Of Extruded Puffed Snack Utilizing Carrot Pomace, Bean Flour, And Rice Starch As Primary Ingredients, Julia Zoe
Master's Theses
Every year, the carrot industry worldwide wastes up to 50% of carrots as raw material due to processing (Šeregelj et al., 2020). When carrots are juiced, the remaining fibrous pulp is often discarded as carrot pomace. In order to redirect this food waste, the first objective of this research was to optimize formulations for an extruded puffed snack that is most similar to commercially available puffed snacks, utilizing baby lima bean flour and carrot pomace
Hardness (kg), cross-sectional expansion ratio, bulk density (g/cm3), moisture content (%), water activity, specific mechanical energy (kJ/kg), carotenoid concentration (ppm), and total dietary …
Survey Of Soilborne Pathogens Infecting Strawberry In Oxnard, California & Effect Of Planting Date And Chill Treatment On Yield Of Strawberry, Samantha Z. Simard
Survey Of Soilborne Pathogens Infecting Strawberry In Oxnard, California & Effect Of Planting Date And Chill Treatment On Yield Of Strawberry, Samantha Z. Simard
Master's Theses
Survey to quantify the frequency of the five main pathogens (Macrophomina phaseolina, Fusarium oxysporum f. sp. fragariae races 1 and 2, Verticillium dahliae, and Phytophthora spp.) infecting strawberry in the Oxnard growing district of California. M. phaseolina was the most prevalent pathogen detected in diseased plants in the Oxnard growing district, present in 67.6% of samples positive for at least one pathogen. F. oxysporum f. sp. fragariae race 1 (35.3%), V. dahlia (8.8%), F. oxysporum f. sp. fragariae race 2 (5.9%) and Phytophthora spp. (2.9%) followed at lower prevalence. Associations were found between fewer drip irrigation lines …
Draft Genome Sequences Of Four Corynebacterium Amycolatum Strains Isolated From Female Urine Samples, Alex Kula, Grace Chilton, James Damaso, Yusef Golzar, Fatima Rushnaiwala, Helen Appleberry, Alan J. Wolfe, Catherine Putonti
Draft Genome Sequences Of Four Corynebacterium Amycolatum Strains Isolated From Female Urine Samples, Alex Kula, Grace Chilton, James Damaso, Yusef Golzar, Fatima Rushnaiwala, Helen Appleberry, Alan J. Wolfe, Catherine Putonti
Biology: Faculty Publications and Other Works
Corynebacterium amycolatum is an emerging pathogen of the urinary tract. Here, we present the draft genomes for four strains isolated from urine collected from symptomatic and asymptomatic female participants.
Understanding The Mystery Of R-Loops And Their Relationship To Nucleolar Stress, Kevin Shane
Understanding The Mystery Of R-Loops And Their Relationship To Nucleolar Stress, Kevin Shane
Master's Theses
Genomic instability is an increase in the likelihood of DNA mutations and genetic changes during cell division, a common feature in cancer cells. One cause of genomic instability comes from the aberrant formation of three-stranded nucleic acid structures called R-loops. R-loop form when an RNA strand hybridizes to its complementary strand of DNA, forming a stable RNA:DNA hybrid and displacing one free strand of DNA 1. Accumulation of unscheduled R-loops can lead to replication stress, fork collision, gene expression changes, and double-strand breaks that are underlying causes of genome instability and the development of many diseases, including cancer 2. Many …
Multi-Institutional Audit Of Flash And Conventional Dosimetry With A 3d Printed Anatomically Realistic Mouse Phantom, M Ramish Ashraf, Stavros Melemenidis, Kevin Liu, Veljko Grilj, Jeannette Jansen, Brett Velasquez, Luke Connell, Joseph B Schulz, Claude Bailat, Aaron Libed, Rakesh Manjappa, Suparna Dutt, Luis Soto, Brianna Lau, Aaron Garza, William Larsen, Lawrie Skinner, Amy S Yu, Murat Surucu, Edward E Graves, Peter G Maxim, Stephen F Kry, Marie-Catherine Vozenin, Emil Schüler, Billy W Loo
Multi-Institutional Audit Of Flash And Conventional Dosimetry With A 3d Printed Anatomically Realistic Mouse Phantom, M Ramish Ashraf, Stavros Melemenidis, Kevin Liu, Veljko Grilj, Jeannette Jansen, Brett Velasquez, Luke Connell, Joseph B Schulz, Claude Bailat, Aaron Libed, Rakesh Manjappa, Suparna Dutt, Luis Soto, Brianna Lau, Aaron Garza, William Larsen, Lawrie Skinner, Amy S Yu, Murat Surucu, Edward E Graves, Peter G Maxim, Stephen F Kry, Marie-Catherine Vozenin, Emil Schüler, Billy W Loo
Faculty, Staff and Student Publications
Purpose: We conducted a multi-institutional dosimetric audit between FLASH and conventional dose rate (CONV) electron irradiations by using an anatomically realistic 3-dimensional (3D) printed mouse phantom.
Methods and materials: A computed tomography (CT) scan of a live mouse was used to create a 3D model of bony anatomy, lungs, and soft tissue. A dual-nozzle 3D printer was used to print the mouse phantom using acrylonitrile butadiene styrene (∼1.02 g/cm3) and polylactic acid (∼1.24 g/cm3) simultaneously to simulate soft tissue and bone densities, respectively. The lungs were printed separately using lightweight polylactic acid (∼0.64 g/cm3). Hounsfield units (HU), densities, and print-to-print …
Nanoscale Gold Nanoparticle (Gnp)-Laden Tumor Cell Model And Its Use For Estimation Of Intracellular Dose From Gnp-Induced Secondary Electrons, Sandun Jayarathna, Amrit Kaphle, Sunil Krishnan, Sang Hyun Cho
Nanoscale Gold Nanoparticle (Gnp)-Laden Tumor Cell Model And Its Use For Estimation Of Intracellular Dose From Gnp-Induced Secondary Electrons, Sandun Jayarathna, Amrit Kaphle, Sunil Krishnan, Sang Hyun Cho
Faculty, Staff and Student Publications
Background: Gold nanoparticles (GNPs) accumulated within tumor cells have been shown to sensitize tumors to radiotherapy. From a physics point of view, the observed GNP-mediated radiosensitization is due to various downstream effects of the secondary electron (SE) production from internalized GNPs such as GNP-mediated dose enhancement. Over the years, numerous computational investigations on GNP-mediated dose enhancement/radiosensitization have been conducted. However, such investigations have relied mostly on simple cellular geometry models and/or artificial GNP distributions. Thus, it is at least desirable, if not necessary, to conduct further investigations using cellular geometry models that properly reflect realistic cell morphology as well as …