Life Sciences Commons^™

Arthropod Arbiters: Natural Enemy Communities Mediate The Effects Of Landscape And Local-Scale Complexity On Lygus-Induced Crop Loss In Organic Strawberries, Adrian Lu, David J. Gonthier, Amber Sciligo, Karina Garcia, Taiki Chiba, Gila Juárez, Claire Kremen

Entomology Faculty Publications

Sustainable pest management requires growers and regional land managers to consider the relationships among pest management practices, pest and natural enemy communities, crop loss, and multi-scalar habitat complexity. However, the causal links among these variables, in particular potential interactions between landscape and local-scale habitat complexity, remain underexplored. In the context of organically managed strawberry crops in California’s Central Coast, we tested the independent effects of landscape and local habitat complexity gradients on arthropod communities and crop loss using a piecewise structural equation model (PSEM). We found that landscape-scale woody habitat proportion indirectly decreased crop loss through its positive effect on …

Characterization Of Cortical Bone In Osteogenesis Imperfecta, Katarina Radmanovic

Dissertations (1934 -)

Osteogenesis imperfecta (OI) is a heritable bone fragility disorder characterized by skeletal deformities and frequent fractures. Impairment of the collagen network in bone reduces bone quality and quantity, increasing the risk of fracture. The corrective osteotomy required to insert a rod into a long bone during corrective orthopaedic surgeries in OI excises at least one small bone wedge. Research on these specimens is beginning to offer valuable insight into the material behavior and modeling potential for improved orthopaedic treatment. There is a paucity of data on macroscopic properties and microstructural metrics as well as limited correlation analyses performed between them …

Benefits Of Calorie Restriction In Mice Are Mediated Via Energy Imbalance, Not Absolute Energy Or Protein Intake, Daniel L Smith, Sharon E Mitchell, Maria S Johnson, Victoria K Gibbs, Stephanie Dickinson, Beate Henschel, Rui Li, Kathryn A Kaiser, Daniella E Chusyd, Andrew W Brown, David B Allison, John R Speakman, Tim R Nagy

Children’s Nutrition Research Center Staff Publications

Caloric restriction (CR) results in reduced energy and protein intake, raising questions about protein restriction's contribution to CR longevity benefits. We kept ad libitum (AL)-fed male C57BL/6J mice at 27°C (AL27) and pair-fed (PF) mice at 22°C (22(PF27)). The 22(PF27) group was fed to match AL27 while restricted for calories due to cold-induced metabolism. The 22(PF27) mice had significantly lower body weight, lean mass, fat mass, leptin, IGF-1, and TNF-α levels than AL27 mice (p< 0.001 for all). Manipulations over ~11 weeks resulted in significant differences in body temperature, physical activity, and expression of key genes linked to hunger in the hypothalamus. Survival was significantly greater in 22(PF27) compared to AL27 overall (p< 0.001). CR in the context of equivalent energy and protein intake resulted in hormonal, metabolic, and physiological benefits and extended longevity. Hence, energy imbalance, rather than low energy or protein intake per se, mediates the benefits of CR.

Pulmonary Vascular Manifestations Of Hereditary Haemorrhagic Telangiectasia, Sarah Cullivan, Barry Kevane, Brian Mccullagh, Terry M O'Connor, Robin Condliffe, Sean Gaine

Children’s Nutrition Research Center Staff Publications

Hereditary haemorrhagic telangiectasia (HHT) is an autosomal dominant, multisystem disorder that manifests with a spectrum of disease including cardiopulmonary complications. HHT is characterised by aberrant signalling via the transforming growth factor β (TGFβ) pathway, with loss of vascular integrity, angiogenesis and vascular dysplasia. The disease has an estimated prevalence of 1 in 5000 persons and the penetrance increases with increasing age. HHT commonly presents with epistaxis and telangiectasia, while visceral arteriovenous malformations are not uncommon. Mutations in the ENG, ACVRL1 and MADH4 genes account for 97% of all HHT cases, and it is recommended that genetic tests are used in …

Ontogenetic Biomechanics Of Tufted (Sapajus) And Untufted (Cebus) Capuchin Mandibles, Taylor A. Polvadore, Caitlin B. Yoakum, Parker M. Taylor, Megan A. Holmes, Myra F. Laird, Janine Chalk-Wilayto, Claudia Misue Kanno, Jose Americano De Oliveira, Claire E. Terhune

Anthropology Faculty Publications and Presentations

Objectives

Cortical bone geometry is commonly used to investigate biomechanical properties of primate mandibles. However, the ontogeny of these properties is less understood. Here we investigate changes in cortical bone cross-sectional properties throughout capuchin ontogeny and compare captive versus wild, semi-provisioned groups. Tufted capuchins (Sapajus spp.) are known to consume relatively hard/tough foods, while untufted capuchins (Cebus spp.) exploit less mechanically challenging foods. Previous research indicates dietary differences are present early in development and adult Sapajus mandibles can resist higher bending/shear/torsional loads.

Materials and methods

This study utilized microCT scans of 22 Cebus and 45 Sapajus from early …

La Salud Es Importante: Libro De Actividades (80-Pages), Your Very Favorite, Children's Health, Lorraine Sheldon, May Bressler

Spanish

Health Matters! is a Spanish-language health literacy resource designed for pediatric patients and their families. Written at an approximately 6th-grade reading level, it supports patient education through engaging coloring and activity pages.

The content covers a wide range of health and wellness topics, including body systems, nutrition, mental wellness, patient safety, and social-emotional skills such as building friendships and navigating conversations when returning to school. Developed for use in both hospital settings and the broader community, the resource promotes learning through interactive, age-appropriate activities.

This printable PDF version contains the complete collection of activities and comprises 80 pages. The resource …

Considerations For Widespread Implementation Of Blood-Based Biomarkers Of Alzheimer's Disease, Michelle Mielke, Matthew Anderson, Wesson Ashford, Andreas Jeromin, Pei-Jung Lin, Allyson Rosen, Jamie Tyrone, Lawren Vandevrede, Deanna Willis, Zul Merali

Brain and Mind Institute

Diagnosing Alzheimer's disease (AD) poses significant challenges to health care, often resulting in delayed or inadequate patient care. The clinical integration of blood-based biomarkers (BBMs) for AD holds promise in enabling early detection of pathology and timely intervention. However, several critical considerations, such as the lack of consistent guidelines for assessing cognition, limited understanding of BBM test characteristics, insufficient evidence on BBM performance across diverse populations, and the ethical management of test results, must be addressed for widespread clinical implementation of BBMs in the United States. The Global CEO Initiative on Alzheimer's Disease BBM Workgroup convened to address these challenges …

Recommendations For Clinical Implementation Of Blood-Based Biomarkers For Alzheimer's Disease, Michelle Mielke, Matthew Anderson, Wesson Ashford, Andreas Jeromin, Pei-Jung Lin, Allyson Rosen, Jamie Tyrone, Lawren Vandevrede, Deanna Willis, Zul Merali, Chinedu Momoh

Brain and Mind Institute

Blood-based biomarkers (BBM) for Alzheimer's disease (AD) are being increasingly used in clinical practice to support an AD diagnosis. In contrast to traditional diagnostic modalities, such as amyloid positron emission tomography and cerebrospinal fluid biomarkers, BBMs offer a more accessible and lower cost alternative for AD biomarker testing. Their unique scalability addresses the anticipated surge in demand for biomarker testing with the emergence of disease-modifying treatments (DMTs) that require confirmation of amyloid pathology. To facilitate the uptake of BBMs in clinical practice, The Global CEO Initiative on Alzheimer's Disease convened a BBM Workgroup to provide recommendations for two clinical implementational …

(Si13-09) Numerical Methods For Solving Nonlinear Fisher Equation Using Backward Differentiation Formula, Vikash Vimal, Rajesh Kumar Sinha, Liju Pannikkal

Applications and Applied Mathematics: An International Journal (AAM)

This paper examines the numerical solution of the nonlinear Fisher equation that is used to find the growth of tumour cells in the brain. By employing new methods that transform nonlinear partial differential equations (PDE) into nonlinear ordinary differential equations (ODE) through spatial discretization. The stability of the resulting nonlinear system is evaluated using Lyapunov’s criteria. Implicit stiff solvers, including various orders of backward differentiation formulas, are used to address the ODE system. The efficiency of these numerical methods is demonstrated through two examples, and a comparison with existing methods from the literature is conducted. Compared to traditional methods, the …

Effect Of S-Metolachlor And Flumioxazin Herbicides On Sweetpotato Treated With And Without Activated Charcoal Applied Through Transplant Water, Colton D. Blankenship, Katherine M. Jennings, David W. Monks, Stephen L. Meyers, David L. Jordan, Jonathan R. Schultheis, David H. Suchoff, Levi D. Moore, Stephen J. Ippolito

Department of Horticulture & Landscape Architecture Faculty Publications

Flumioxazin and S-metolachlor are widely used in conventional sweetpotato production in North Carolina and other states; however, some growers have recently expressed concerns about potential effects of these herbicides on sweetpotato yield and quality. Previous research indicates that activated charcoal has the potential to reduce herbicide injury. Field studies were conducted in 2021 and 2022 to determine whether flumioxazin applied preplant and S-metolachlor applied before and after transplanting negatively affect sweetpotato yield and quality when activated charcoal is applied with transplant water. The studies evaluated five herbicide treatments and two activated charcoal treatments. Herbicide treatments included two flumioxazin rates, one …

Feral Camel, Department Of Primary Industries And Regional Development, Western Australia

Biosecurity factsheets

No abstract provided.

Feral Donkey, Department Of Primary Industries And Regional Development, Western Australia

Biosecurity factsheets

Donkeys (Equus asinus) were first imported in substantial numbers to Australia in 1866 by Sir Thomas Elder. They were used as pack and draught animals in outlying areas of Western Australia (WA) until the 1930s. They were eventually replaced by the motor vehicle, and unwanted donkeys were released to the wild, where they became feral. The first record of feral donkeys is from the Kimberley in the early 1930s, but it is possible they became feral much earlier.

Blackbird, Department Of Primary Industries And Regional Development, Western Australia

Biosecurity factsheets

The introduced common blackbird (Turdus merula) is a pest in eastern Australia. It damages commercial fruit crops and may compete with native birds. The species is prohibited in Western Australia and individuals found here are destroyed.

The Western Australian Organism List (WAOL) contains information on the area(s) in which this pest is declared and the control and keeping categories to which it has been assigned in Western Australia (WA). For more information, see our website at dpird.wa.gov.au.

Feral Goat, Department Of Primary Industries And Regional Development, Western Australia

Biosecurity factsheets

The goat (Capra hircus) was one of the first animals to be domesticated, 8 to 10 thousand years ago. Archaeological work indicates the earliest attempts at domestication were in dry hills surrounding the Mediterranean basin. The ability of goats to utilise the coarse browse of mountainous areas made them suitable for domestication, in preference to sheep. With large-scale domestication of goats throughout the world, goats escaped and established feral goat herds on most continents. Overgrazing by goats has caused severe environmental damage, worldwide.

Goats arrived in Australia with the first fleet. They were introduced to many areas by early settlers …

Rabbit Control: 1080 Versus Pindone, Department Of Primary Industries And Regional Development, Western Australia

Biosecurity factsheets

There are two toxins available for controlling pest rabbits in Western Australia: 1080 and pindone. This factsheet provides a brief summary of the main characteristics of both vertebrate pesticides. 1080 is generally the preferred toxin for rabbit control in Western Australia (WA).

Any attempt to reduce the impact of rabbits on the productivity of any agricultural enterprise (for example, pasture, crops, tree farms, horticulture) should be undertaken as part of a pest management plan.

This strategy should be proactive rather than reactive to a problem. It should also include a long term strategy for dealing with potential rabbit damage, including …

On The Line And Online: Higher Non-Response To Web-Based Surveys Over-Represents Avid Recreational Fishers Compared With Telephone Surveys, Karina L. Ryan, Steve Taylor, Jeremy M. Lyle, Kate Stark, Sean R. Tracey

Fisheries Research Articles

Recreational fishing surveys have an important role in providing data to inform fisheries management. The selection of a contact method is an important and often challenging consideration that influences the potential for non-sampling errors that can result in unrepresentative data and biased estimates. Telephones are used for many off-site recreational fishing surveys, but widespread use of digital technology suggests that online surveys could be a viable alternative. We compared phone surveys with alternative online surveys using probability sampling from a licence database. Response rates were lower for online surveys (13%–26%) than phone surveys (97%–98%). The proportion of respondents who reported …

Three-Horned Bedstraw, Department Of Primary Industries And Regional Development, Western Australia

Biosecurity factsheets

Three-horned bedstraw (Galium tricornutum), otherwise known as bedstraw, rough bedstraw, rough fruit corn bedstraw, and corn cleavers, is an annual weed that poses a significant threat to Western Australia’s grains industry. It is a declared pest in Western Australia (WA). A weedy member of the Rubiaceae (madder family), it is closely related to cleavers (Galium aparine)

Bedstraw is a high priority eradication target for Western Australia.

Red Fox, Department Of Primary Industries And Regional Development, Western Australia

Biosecurity factsheets

This factsheet provides information on the red fox in Western Australia (WA).

The red fox (Vulpes vulpes) is a native of the northern hemisphere where it occurs throughout most of Europe, Asia, North America, and the northern coast of Africa. The red fox was first introduced to Australia (Victoria) from Britain as early as 1845 for hunting with foxhounds. Having become successfully established in Victoria by about 1870, it colonised most of mainland Australia over the next 70 years. Foxes are not found in the most northern regions of Australia, including northwest Kimberley.

In WA, the fox is a declared …

Rabbit Control: Fumigation, Department Of Primary Industries And Regional Development, Western Australia

Biosecurity factsheets

Fumigation for rabbit control involves the introduction of poisonous gas into a warren. It is one of the best control methods to use where low numbers of rabbits live in a few widely scattered warrens. The threat to non-target animals is minimal. This factsheet should be read in conjunction with registered product labels and directions for use. Check the Department of Health, Western Australia website (health.wa.gov.au) for public health requirements for the use of phosphine fumigation.

Fumigation may be used in areas where access is limited, such as fence lines, around trees, and on riverbanks, but it may be difficult …

Exploring The Influence Of Molecular Chaperones On The Aggregation Of Transthyretin, Adam S. Knier

Dissertations (1934 -)

Molecular chaperones assist in maintaining protein homeostasis by limiting protein aggregation, including populations of protein aggregates that may be associated with the onset of debilitating and/or often fatal diseases. Chaperones are known to limit protein aggregate populations through disaggregase activity, in which chaperone complexes work together to disassemble multi-subunit aggregate species into smaller populations, or holdase activity, in which chaperones bind to proteins or smaller aggregates to prevent further aggregation. In this dissertation we assess if molecular chaperones can limit the aggregation of human transthyretin (TTR) expressed within a yeast system and explore the relationship between chaperone concentration and activity. …

A Dendrochronological Analysis Of Longleaf And Associated Pines From The Blackwater Ecological Preserve In Southeastern Virginia, Sarah Durham

Biological Sciences Theses & Dissertations

The field of dendrochronology utilizes annual tree ring growth data to create chronologies, which function as proxies to measure the effect of climate on radial growth. In the southeastern United States, dendrochronological studies involving the effect of climate on the growth of Pinus species exist, but significant gaps persist. For this study, I: 1) created chronologies of earlywood, latewood, and total ring-width growth for longleaf pine (Pinus palustris Mill.), loblolly pine (P. taeda L.), and pond pine (P. serotina Michx.) and 2) conducted a climate analysis on each species to determine how climatic factors affected radial …

Intercellular Mitochondrial Transfer Contributes To Microenvironmental Fate Redirection Of Mammary Cancer Cells, Julie Sofie Bjerring

Biomedical Sciences Theses & Dissertations

The dynamic cellular microenvironment, made up of resident cells and various macromolecules, differs markedly across tissues in the body. The multidirectional signals that cells receive from this microenvironment, along with the signaling they send back, heavily influence their physiology and behavior. Recent important findings have further validated this notion as the mammary microenvironment has been shown to suppress tumor progression by redirecting cancer cells to adopt a normal mammary epithelial progenitor fate in vivo. However, the mechanism(s) driving changes in metabolic reprogramming and cancer fate redirection is understudied. The work presented in this dissertation focuses on exploring the impact of …

The Anaerobic Rose Chamber (Arc): Novel Applications For Probing Clostridioides Difficile Dynamics, Tatiana Zvonareva

Chemistry & Biochemistry Theses & Dissertations

Clostridioides difficile infection (CDI) is an urgent public health threat with a high rate of recurrence and limited treatment options. Caused by the anaerobic intestinal pathogen C. difficile, this disease affects up to 500,000 Americans annually. Despite progress in our understanding of CDI pathophysiology, the lack of effective and accessible experimental platforms compatible with obligate anaerobe physiology hinders the advancement of treatment therapy. The application of in vivo models has been indispensable in understanding CDI pathophysiology, probing the complexity of the host response to the microbe, and establishing treatment protocols, and it continues to be essential in preclinical testing. …

Assess Weed Population Density, Department Of Primary Industries And Regional Development, Western Australia

Grains and other field crops factsheets

The most accurate way to estimate the weed population of a paddock is to count the number of plants in an area of known size at numerous locations.

Use a quadrant, which may be square or circular, to carry out weed plant counts. The number and location of counts needed to estimate the weed population will vary depending on the distribution pattern.

Canola – Essentials For Growing A Successful Crop, Department Of Primary Industries And Regional Development, Western Australia

Grains and other field crops factsheets

Ensuring the basics of canola agronomy are followed can minimise the financial risk of growing canola, which can be higher than other crops due to high input costs, particularly seed and fertiliser.

Barley Leaf Diseases And Their Management, Department Of Primary Industries And Regional Development, Western Australia

Grains and other field crops factsheets

Barley leaf diseases such as scald, net blotches (net form and spot form), powdery mildew, ramularia leaf spot, leaf rust, and barley yellow dwarf virus, and cereal yellow dwarf virus can reduce yield and grain quality. Correct identification is important in disease management, as diseases differ in their best management strategies.

Hay Production, Department Of Primary Industries And Regional Development, Western Australia

Grains and other field crops factsheets

There are specific requirements for hay for the export market that are different to usual on-farm requirements. These include earlier cutting times, green hay colour, low moisture content, freedom from weeds, and thin-strawed varieties.

Some oat varieties do not meet the exporter’s standard and therefore will not be accepted for delivery. Growers interested in the export market should check with individual exporters for their requirements.

Variety information can be found in the department’s current Western Australian crop sowing guide, available on the website at dpird.wa.gov.au.

Insect Pests And Their Management In Oats, Department Of Primary Industries And Regional Development, Western Australia

Grains and other field crops factsheets

Field pests

Damage from invertebrate pests is generally not a major factor for oat crops, however there is a zero tolerance to live pests in export hay.

Significant damage can occur if pest populations build up. Planning rotations to minimise pest carryover, timely sowing, adequate crop nutrition, and good control of weed and root diseases will assist in reducing the likelihood of crop damage by insect pests. Check crops regularly throughout their growth for field insects.

• Control redlegged earth mite and lucerne flea during the seedling stage if necessary.

• Aphids should be checked for and controlled from flag …

Factors Affecting Herbicide Performance, Department Of Primary Industries And Regional Development, Western Australia

Grains and other field crops factsheets

Herbicide performance can vary greatly depending on factors including compatibility of herbicides, water quality, sprayer decontamination, and controlling stressed weeds. This page outlines these issues and demonstrates how to assess herbicide performance to achieve the best from your herbicides.

Knockdown Of Ketohexokinase Versus Inhibition Of Its Kinase Activity Exert Divergent Effects On Fructose Metabolism, Se-Hyung Park, Taghreed Fadhul, Lindsey R. Conroy, Harrison A. Clarke, Ramon Sun, Kristina Wallenius, Jeremie Boucher, Gavin O'Mahony, Alessandro Boianelli, Marie Persson, Sunhee Jung, Cholsoon Jang, Analia S. Loria, Genesee J. Martinez, Zachary A. Kipp, Evelyn A. Bates, Terry D. Hinds Jr., Senad Divanovic, Samir Softic

Markey Cancer Center Faculty Publications

Excessive fructose intake is a risk factor for the development of obesity and its complications. Targeting ketohexokinase (KHK), the first enzyme of fructose metabolism, has been investigated for the management of metabolic dysfunction–associated steatotic liver disease (MASLD). We compared the effects of systemic, small molecule inhibitor of KHK enzymatic activity with hepatocyte-specific, N-acetylgalactosamine siRNA–mediated knockdown of KHK in mice on an HFD. We measured KHK enzymatic activity, extensively quantified glycogen accumulation, performed RNA-Seq analysis, and enumerated hepatic metabolites using mass spectrometry. Both KHK siRNA and KHK inhibitor led to an improvement in liver steatosis; however, via substantially different mechanisms, KHK …