Life Sciences Commons^™

Racial And Sociodemographic Disparities In The Use Of Targeted Therapies In Advanced Ovarian Cancer Patients With Medicare, Anne Knisely, Chi-Fang Wu, Alexa Kanbergs, Nuria Agusti, Kirsten A Jorgensen, Sharon H Giordano, Roni Nitecki Wilke

Faculty, Staff and Student Publications

Objective: To describe sociodemographic and racial disparities in receipt of poly ADP-ribose polymerase inhibitors (PARPi) and bevacizumab among insured patients with ovarian cancer.

Methods: This retrospective study used the Surveillance, Epidemiology, and End Results (SEER)-Medicare database to identify patients with advanced stage, high grade serous ovarian cancer diagnosed between 2010 and 2019. The primary outcome of interest was receipt of PARPi or bevacizumab at any time after diagnosis. χ2 tests were used to compare categorical variables. Factors independently associated with the receipt of PARPi and/or bevacizumab were identified using a multivariable logistic regression.

Results: The cohort included 6242 patients; 276 …

Thrombosis, Brain Metastasis Formation, And The Perivascular Metastatic Niche-Novel Insights From The Tumor Microvascular Circulation, Christopher Alvarez-Breckenridge, Priscilla K Brastianos, Daniel P Cahill

Faculty, Staff and Student Publications

No abstract provided.

Impa1-Derived Inositol Maintains Stemness In Castration-Resistant Prostate Cancer Via Impdh2 Activation, Zhen Cai, Tingjin Chen, Bo-Syong Pan, Rajesh Kumar Manne, Gagan Deep, Haiwei Gu, Yuzhuo Wang, Danni Peng, Vasudevarao Penugurti, Xiaobo Zhou, Zhigang Xu, Zhongzhu Chen, Ming Chen, Andrew J Armstrong, Jiaoti Huang, Hong-Yu Li, Hui-Kuan Lin

Faculty, Staff and Student Publications

Acquisition of prostate cancer stem cells (PCSCs) manifested during androgen ablation therapy (ABT) contributes to castration-resistant prostate cancer (CRPC). However, little is known about the specific metabolites critically orchestrating this process. Here, we show that IMPA1-derived inositol enriched in PCSCs is a key metabolite crucially maintaining PCSCs for CRPC progression and ABT resistance. Notably, conditional Impa1 knockout in the prostate abrogates the pool and properties of PCSCs to orchestrate CRPC progression and prolong the survival of TRAMP mice. IMPA1-derived inositol serves as a cofactor that directly binds to and activates IMPDH2, which synthesizes guanylate nucleotides for maintaining PCSCs with ARlow/- …

Integrating Ecophysiology And Omics To Unlock Crop Response To Drought And Herbivory Stress, Insha Shafi, Manish Gautam, Rupesh Kariyat

Entomology Faculty Publications and Presentations

Introduction: Plants are constantly exposed to a diverse spectrum of environmental stressors that typically occur concurrently as multifactorial challenges, both spatially and temporally (Joshi et al., 2024). These stressors include abiotic stresses, such as drought, flooding, salinity, nutrient deficiencies, metal toxicity and extreme temperatures, as well as biotic pressures such as herbivory, pathogen attacks, and inter and intraspecific competition (Porter et al., 2020; González Guzmán et al., 2022). Drought and herbivory are arguably among the most critical factors that limit crop productivity in agricultural settings (Gautam et al., 2024), making it imperative to understand plant responses to their combined effects. …

2024-25 Women In Science Conference Schedule (Pdf), Lynn University

Women in Science Conference

2024-25 Women in Environmental Science Conference Schedule (PDF)

Tak1 Blockade Plus Azacitidine Induces Apoptosis, Augments Cytarabine, And Ablates Clonogenicity In Mll-Af9+ Human Aml Cell Lines, Austin P. Runde, Cameron Lewis, Peter Breslin Sj, Jiwang Zhang

School of Medicine

Acute myeloid leukemia (AML) encompasses a diverse group of cancers that originate in the blood-forming tissues of the bone marrow [1]. Aside from the PML-RARA⁺ subtype, AML carries a 5-year survival rate of 28% for patients 20+ years of age. AML is the most common cancer of the hematopoietic system and is slightly more common in biological males; the average age at diagnosis is 68 years. Standard frontline treatment for AML is a two-phase regimen of intensive chemotherapy (CTx) employing daunorubicin and cytarabine; etoposide may also be added in select regimens. Despite 60-70% of patients achieving complete remission (CR), …

A Decade Of Monitoring Reveals A Dynamic Fish Assemblage On A Substantial Artificial Reef In The Texas Gulf Of Mexico, David Hicks, Ethan T. Getz, Richard Kline, Carlos E. Cintra-Buenrostro

School of Earth, Environmental, & Marine Sciences Faculty Publications

Fish communities on artificial reefs have rarely been monitored over long periods to evaluate success of reef deployment. Here, we used roving diver surveys to assess changes in fish assemblages on a large, reefed vessel during 2008–2017. Multivariate analyses revealed a dynamic community that stabilized after 5 years. Species richness increased and species dominance decreased during 2008–2017. The fish community shifted toward reef-associated species such as hogfish and pufferfish. Species composition shifted, but trophic structure was relatively stable, which suggested that functional groups may not reflect larger community shifts. Our results indicate that fish communities on artificial reefs are temporally …

Notes On North American Butterflies, 2, Harry Pavulaan, Janice E. Arndt

The Taxonomic Report of the International Lepidoptera Survey

New natural history elements and distribution records of several North American butterflies are reported. While diversity and distribution of butterflies in North America are commonly believed to be fully known, the findings presented here show that much is yet to be learned of our butterfly fauna.

Determining The Long-Term Effectiveness Of Seeding Post-Dam Removal In The Elwha River, Wa, Through Soil Seed Bank Analysis, Makenna Tabino, Rebecca Brown

2024 Symposium

Following the historic dam removal along the Elwha River in Olympic National Park, we are evaluating the impact of seeding in the former Lake Mills reservoir by examining the soil seed bank composition. The Elwha River had the largest dam removal project in history, and the second largest ecological restoration project in National Parks Service history. Active restoration (seeding and planting) took place in terraces and valley walls, the two dominant landform types found in the former reservoir. While the plant community in the former dam reservoirs is well documented, the soil seed bank remains unexplored.

My objective is to …

Leisure-Time Physical Activity And Motivation In Police Cadets: A Self-Determination Study, Sébastien Poirier, François Trudeau, Julie Houle

International Journal of Exercise Science

International Journal of Exercise Science 17(5): 1504-1516, 2024. Several studies have highlighted the importance of leisure-time physical activity (LTPA) for the health and performance of law enforcement officers. Nevertheless, a considerable proportion of officers still fail to engage in any LTPA. There is a clear need to identify correlates of physical activity among this specific occupational group to help the design of workplace physical activity interventions. Rooted in the self-determination theory, this study seeks to assess the LTPA level of police cadets and examine its relationship with the different regulatory forms of motivation. In this cross-sectional study, 188 police cadets …

Proceedings From The Fifth Annual For Society For Sports Neuroscience Conference, Neurosports Editorial Staff

Journal for Sports Neuroscience

Proceedings from the Fifth Annual for Society for Sports Neuroscience Conference

Tradeoffs In Longleaf Pine Conservation: Prescribed Fire Management Increases Exotic Ambrosia Beetle Abundance In Pine-Hardwood Forests, Davide Nardi, Hannah Bares, Natalie A. Clay, Robin M. Verble, Davide Rassati, Lorenzo Marini, John Thomason, John J. Riggins

Biological Sciences Faculty Research & Creative Works

Exotic woodboring insects, including some ambrosia beetles (Coleoptera: Curculionidae, Scolytinae, and Platypodidae), are threatening native forests worldwide. Longleaf pine (Pinus palustris Mill.) forest is an endangered habitat in the southeastern United States. One of the most important actions necessary for its conservation is prescribed fire, which maintains its savanna structure. However, prescribed fire is a forest disturbance, possibly creating new niches for colonization by exotic insects. The interaction between prescribed fire and exotic ambrosia species is understudied, especially in highly fire-dependent ecosystems. We carried out a two-year experiment in mixed longleaf pine forests in Alabama, USA. We compared ambrosia beetle …

Confocal Raman Spectroscopy Coupled With In Vitro Permeation Testing To Study The Effects Of Formalin Fixation On The Skin Barrier Function Of Reconstructed Human Epidermis, Hichem Kichou, Franck Bonnier, Amanda C. Caritá, Hugh Byrne, Igor Choupra, Emilie Munnier

Articles

Confocal Raman Spectroscopy is recognised as a potent tool for molecular characterisation of biological specimens. There is a growing demand for In Vitro Permeation Tests (IVPT) in the pharmaceutical and cosmetic areas, increasingly conducted using Reconstructed Human Epidermis (RHE) skin models. In this study, chemical fixation of RHE in 10% Neutral Buffered Formalin for 24 hours has been examined for storing RHE samples at 4°C for up to 21 days. Confocal Raman Spectroscopy, combined with Principal Components Analysis, revealed the molecular-level effects of fixation, notably in protein and lipid conformation within the stratum corneum and viable epidermis. IVPT by means …

Evaporation Basins For Salinity Management, Department Of Primary Industries And Regional Development, Western Australia

Natural resources factsheets

An evaporation basin is an engineered earth structure designed to safely store and evaporate saline water discharged from drainage or pumping, while protecting high-value agricultural land, natural assets or built infrastructure.

DPIRD recommends that evaporation basins should form part of an integrated water and salinity management program. Information on this page is a guide only.

It is recommended that landholders seek expert advice plus engineering design and related support from qualified contractors.

Prediction Of Turfgrass Quality Using Multispectral Uav Imagery And Ordinal Forests: Validation Using A Fuzzy Approach, Alexander Hernandez, Shaun Bushman, Paul Johnson, Matthew D. Robbins, Kaden Patten

Plants, Soils, and Climate Faculty Publications

Protocols to evaluate turfgrass quality rely on visual ratings that, depending on the rater’s expertise, can be subjective and susceptible to positive and negative drifts. We developed seasonal (spring, summer and fall) as well as inter-seasonal machine learning predictive models of turfgrass quality using multispectral and thermal imagery collected using unmanned aerial vehicles for two years as a proof-of-concept. We chose ordinal regression to develop the models instead of conventional classification to account for the ranked nature of the turfgrass quality assessments. We implemented a fuzzy correction of the resulting confusion matrices to ameliorate the probable drift of the field-based …

Rabbit Control: Bait Products, Department Of Primary Industries And Regional Development, Western Australia

Biosecurity factsheets

This factsheet is part of the bait and poison directory for vertebrate pests in Western Australia (WA). It provides information on bait, poison, and toxin (bait) products available for use in WA to control rabbits (Oryctolagus cuniculus).

For information on how to access bait, poison and toxin (bait) products, training required, animal welfare considerations and legal requirements, refer to the Bait and poison directory for vertebrate pests’ page on the website at dpird.wa.gov.au. Information on bait, poison, and toxin (bait) products available for use in WA for rabbits, is provided below.

Managing Salinity: Fence And Volunteer Pasture, Department Of Primary Industries And Regional Development, Western Australia

Natural resources factsheets

This treatment is recommended for saline sites that can support a mix of salt tolerant species and some non-tolerant pasture species, where livestock are present. It may also be the preferred solution for farmers who wish to see an improvement in their land at low cost.

The department recommends that any dryland salinity management is part of a whole farm, and preferably a whole catchment, water management plan.

Mechanisms Of Extracellular Vesicle Uptake And Implications For The Design Of Cancer Therapeutics, Stephanie R Jackson Cullison, Joseph P Flemming, Kubra Karagoz, Peter J Wermuth, Mỹ G Mahoney

Rowan-Virtua School of Osteopathic Medicine Departmental Research

The translation of pre-clinical anti-cancer therapies to regulatory approval has been promising, but slower than hoped. While innovative and effective treatments continue to achieve or seek approval, setbacks are often attributed to a lack of efficacy, failure to achieve clinical endpoints, and dose-limiting toxicities. Successful efforts have been characterized by the development of therapeutics designed to specifically deliver optimal and effective dosing to tumour cells while minimizing off-target toxicity. Much effort has been devoted to the rational design and application of synthetic nanoparticles to serve as targeted therapeutic delivery vehicles. Several challenges to the successful application of this modality as …

Shallow Relief Drains In Western Australia, Department Of Primary Industries And Regional Development, Western Australia

Natural resources factsheets

Shallow relief drains are easy to construct and a cost-effective way to:

• remove accumulated surface water from depressions and low-lying land
• divert run-off from land that is prone to inundation or flooding
• remove surface water to a safe disposal area, to reduce the length of time the land is inundated or flooded
• reduce the potential for localised recharge and the development of secondary salinity
• improve the continuity of flow within the catchment along the valley floor.

Nebline, November/December 2024

NEBLINE Newsletter Archive from Nebraska Extension in Lancaster County

Positive Insights Shared Regarding CHIME: Head Start University Partnership Project, Jaci Fogel

Diabetes Awareness: Small Changes, Big Impact, Kayla Colgrove

Recipe of the Month: Turkey Cranberry Meatballs, Kayla Colgrove

Commercial/ Noncommercial Pesticide License

Love Gardening? Become a Master Gardener!

Garden Guide: Things to Do This Month

Upcoming Green Industry Conferences

Managing the Demands of Water & Wastewater Systems Can Make Gatherings More Enjoyable, Becky Schauerman

It’s Time to Plant Fall Cover Crops, John Nelson

A Quick Guide to Fleas, Kait Chapman

Heart of 4-H Award: Shane Cuttlers and Dena Noe

4-H Specialty Clubs Invite New Members

Nebraska 4-H Fed Steer …

Cane Toad, Department Of Primary Industries And Regional Development, Western Australia

Biosecurity factsheets

This factsheet provides information about the identification, biology, impact, and management of the cane toad.

The cane toad (Rhinella marina), or giant toad, is native to central and South America. It has been introduced to many countries, including northern and eastern Australia. The cane toad is a declared pest under the Biosecurity and Agriculture Management Act 2007 (BAM Act) in Western Australia (WA). The Western Australian Organism List (WAOL), available on the website at dpird.wa.gov.au) contains information on the area(s) in which this pest is declared, and the control and keeping categories to which it has been assigned in WA.

Measuring Soil Salinity, Department Of Primary Industries And Regional Development, Western Australia

Natural resources factsheets

To make sound decisions on managing saline sites, you need to know the source of salt, how salinisation is occurring, the landscape context, and most importantly, the actual salt concentration of the soil.

The most common 'measures' of salt concentration are actually estimates based on electrical conductivity of a soil and water solution. Soil salt content can be measured in a laboratory by measuring the total dissolved solids in a sample. In the field, salt concentration can also be estimated using electromagnetic induction-based soil sensors.

Integrative Highway Rights-Of-Way Management To Reduce Stormwater Run-Off And Enhance Habitat, Madeline M. Showers, Robin M. Rotman

Faculty Publications

Nature-based management along highway rights-of-way (ROW) has been a focus in several states to benefit pollinators through supporting diverse and native vegetative communities. There is the potential to enhance the ecological benefits of this practice by integrating stormwater management into restoration plans and incorporating other complex, multidisciplinary factors. Historically, lack of technical assistance and limited resources has led managers to use unsustainable roadside practices that reduce the potential ecological services of the ROW; however, integrative management can aid in the prioritization of management efforts and link objectives of various resource agencies. In this literature review, we address the ecological impacts …

Drinking Water Requirements For Livestock Grazing Saltbush, Department Of Primary Industries And Regional Development, Western Australia

Animal production and livestock factsheets

Livestock grazing - saltbush and other plants that have adapted to living in highly saline habitats (known as halophytes), require more water to excrete those salts in urine. If the water they drink is also saline, the total salt intake may limit feed intake, and the animal will be less productive, and its welfare might be compromised.

This page gives a technical explanation of how livestock requirements for water quality and quantity interact with saltbush intake. The information here is a guide only, and you should consult a veterinarian or livestock adviser for specific advice

Sheep Worm Control In Wa, Department Of Primary Industries And Regional Development, Western Australia

Animal production and livestock factsheets

Effective, sustainable control of sheep worms involves a combination of planned stock and farm management, monitoring worm burdens using faecal worm egg counts (WEC), strategic timing of drenches and the genetic selection of worm resistant sheep.

Levels of drench resistance of sheep worms in WA are some of the highest in the world and without resistance management action at individual farm level, it will continue to worsen and spread.

Although effective drench options are generally available, many sheep owners are unaware that resistance has reduced the effectiveness of worm control programs, and this can affect profitable sheep production.

2024 - The Fifth Annual Fall Symposium Of Student Scholars

Symposium of Student Scholars Program Books

The full program book from the Fall 2024 Symposium of Student Scholars, held in November 2024. Includes abstracts from the presentations and posters.

Early Weaning Of Lambs In A Poor Season, Department Of Primary Industries And Regional Development, Western Australia

Animal production and livestock factsheets

The feed requirements of a ewe with a lamb at foot are higher than if the ewe and lambs are fed separately. In a difficult season with short feed supplies, it is better to early-wean lambs from their mothers to lower feed costs and ensure that the ewes regain condition before joining. This issue becomes even more important as the costs of feeds increase.

Ewe's milk provides the main source of nutrition for lambs until about eight weeks of age. Lambs will sample pasture from about two weeks after birth but by eight weeks of age pasture overtakes milk as …

Sheep Lice Spread And Detection, Department Of Primary Industries And Regional Development, Western Australia

Animal production and livestock factsheets

The most common lice affecting sheep are body lice (Bovicola ovis).

Knowledge of the lice life cycle and relevant features of their biology assist in our understanding of how lice survive and spread.

Better understanding and ability to find and monitor lice populations will improve sheep farmer decision making around eradicating lice.

Knowledge of when an infestation may have occurred, or alternatively that lice was not eradicated at the last shearing, is important information that will assist future treatment decisions.

Managing The Beef Breeder Herd In Southern Western Australia, Department Of Primary Industries And Regional Development, Western Australia

Animal production and livestock factsheets

Kilograms of beef produced per hectare is a significant driver of profit for a beef business. Cow longevity (length of productive life) plays an important role in achieving a profitable business. A balanced approach to genetic selection and nutritional management are essential factors underpinning the efficiency of the breeding herd.

Opportunities Using Eid – Tahara Case Study, Department Of Primary Industries And Regional Development, Western Australia

Animal production and livestock factsheets

Starting from 2025, Electronic Identification (EID) will become mandatory in Western Australia. This requirement might cause some farmers to focus solely on the increased costs, potentially overlooking the opportunities these systems can bring to their farms. Clayton South, who manages his property ‘Tahara’ near Wagin in the Great Southern region of WA, operates a farm with approximately 4,000 Dohne ewes. They started using EID in 2014.