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Articles 18721 - 18750 of 256001
Full-Text Articles in Life Sciences
The Efficacy Of Physical Activity Or Exercise Among Individuals With Cerebral Palsy: An Umbrella Review Of Systematic Reviews, Majed M. Alhumaid, Faris Yahya I. Asiri, Mohamed A. Said, Justin A. Haegele
The Efficacy Of Physical Activity Or Exercise Among Individuals With Cerebral Palsy: An Umbrella Review Of Systematic Reviews, Majed M. Alhumaid, Faris Yahya I. Asiri, Mohamed A. Said, Justin A. Haegele
Human Movement Studies & Special Education Faculty Publications
Introduction
Cerebral palsy (CP) is the most common childhood disability, affecting 1.5-3 per 1000 live births. Physical exercises have been shown to improve muscle and limb outcomes in CP. This systematic review critically appraises existing systematic reviews on the effects of physical activity and exercise on physical, functional, and psychosocial outcomes in individuals with CP compared to those without.
Methods
Using a PICO framework, the question was: In patients with CP, do physical activity and exercise improve muscle- and limb-related outcomes compared to no intervention or usual care? PubMed, Cochrane, ISI Web of Science, and Embase were searched for systematic …
Impact Of Aerobic Exercise On Cardiometabolic Health In Patients With Diabesity: A Systematic Review And Meta-Analysis Of Randomized Controlled Trials, Sameer Badri Al-Mhanna, Barry A. Franklin, John M. Jakicic, Emmanuel Stamatakis, Linda S. Pescatello, Deborah Riebe, Walter R. Thompson, James S. Skinner, Sheri R. Colberg, Jonathan K. Ehrman, George S. Metsios, Norsuhana Omar, Nouf H. Alkhamees, Bodor Bin Sheeha, Abdullah F. Alghannam, Alexios Batrakoulis
Impact Of Aerobic Exercise On Cardiometabolic Health In Patients With Diabesity: A Systematic Review And Meta-Analysis Of Randomized Controlled Trials, Sameer Badri Al-Mhanna, Barry A. Franklin, John M. Jakicic, Emmanuel Stamatakis, Linda S. Pescatello, Deborah Riebe, Walter R. Thompson, James S. Skinner, Sheri R. Colberg, Jonathan K. Ehrman, George S. Metsios, Norsuhana Omar, Nouf H. Alkhamees, Bodor Bin Sheeha, Abdullah F. Alghannam, Alexios Batrakoulis
Human Movement Studies & Special Education Faculty Publications
Purpose
This systematic review and meta-analysis of randomized controlled trials (RCTs) aimed to evaluate the effects of aerobic exercise on cardiometabolic health-related indices in patients with type 2 diabetes and concurrent overweight/obesity (diabesity).
Methods
PubMed, Web of Science, Scopus, Science Direct, Cochrane Library, and Google Scholar databases were searched from inception to October 2024. The search strategy included the following keywords: diabetes, aerobic exercise, and endurance training. RCTs comparing aerobic exercise training ≥2 weeks in duration to standard treatment were considered eligible. Participants were adults with diabesity.
Results
A total of 1391 middle-aged/older adult patients (55 % females) were included …
Impact Of High-Intensity Interval Training On Cardiometabolic Health In Patients With Diabesity: A Systematic Review And Meta-Analysis Of Randomized Controlled Trials, Sameer Badri Al-Mhanna, Barry A. Franklin, Mark A. Tarnopolsky, John A. Hawley, John M. Jakicic, Emmanuel Stamatakis, Jonathan P. Little, Linda S. Pescatello, Deborah Riebe, Walter R. Thompson, James S. Skinner, Sheri R. Colberg, Jonathan K. Ehrman, George S. Metsios, Helen T. Douda, Norsuhana Omar, Abdullah F. Alghannam, Alexios Batrakoulis
Impact Of High-Intensity Interval Training On Cardiometabolic Health In Patients With Diabesity: A Systematic Review And Meta-Analysis Of Randomized Controlled Trials, Sameer Badri Al-Mhanna, Barry A. Franklin, Mark A. Tarnopolsky, John A. Hawley, John M. Jakicic, Emmanuel Stamatakis, Jonathan P. Little, Linda S. Pescatello, Deborah Riebe, Walter R. Thompson, James S. Skinner, Sheri R. Colberg, Jonathan K. Ehrman, George S. Metsios, Helen T. Douda, Norsuhana Omar, Abdullah F. Alghannam, Alexios Batrakoulis
Human Movement Studies & Special Education Faculty Publications
Aims This systematic review and meta-analysis aimed to evaluate the effects of high-intensity interval training (HIIT) on cardiometabolic health-related outcomes in patients with type 2 diabetes and obesity (diabesity).
Methods PubMed, Web of Science, Scopus, Science Direct, Cochrane Library, and Google Scholar databases were searched from inception up to November 2024. The search strategy encompassed the following keywords: diabetes, obesity, and HIIT. Randomized controlled trials (RCTs) recruiting adult participants with diabesity and comparing HIIT per se for ≥ 2 weeks in duration with non-exercise standard treatment were included.
Results A total of 18 RCTs qualified involving 504 patients (52/48 women/men …
Calculation Of Proton Transmembrane-Electrostatic Interaction Force And Elucidation Of The Water Droplet Experiment With A Transient Protonic Front, James Weifu Lee
Calculation Of Proton Transmembrane-Electrostatic Interaction Force And Elucidation Of The Water Droplet Experiment With A Transient Protonic Front, James Weifu Lee
Chemistry & Biochemistry Faculty Publications
The “transmembrane-electrostatically localized proton(s)/cation(s) charge(s) (TELC(s), also known as TELP(s)) model” may serve as a theoretical framework to explain protonic cell energetics including both delocalized and localized protonic couplings. TELCs are held by their corresponding transmembrane-electrostatically localized hydroxides anions (TELAs) across the membrane through mutual transmembrane-electrostatic attractive force, which is now calculated to be in the range from 1.96 × 10⁻¹¹ to 2.28 × 10⁻¹¹ newtons (N) across a 2.5 nm thick membrane in a range of transmembrane potential from 10 to 200 mV. At a moderate transmembrane potential (100 mV), the protonic transmembrane attractive force is now calculated to …
Phytochemical Analysis, Antioxidant, And Antibacterial Properties Of Partition Fractions Of Adansonia Digitata And Annona Muricata Extracts Using Chloroform, Ethyl Acetate, Ethanol, And Aqueous Solvent Systems, Fagbohun Oyenike Bushirat, Hassan Abdusalam Adewuyi, Sakariyau Adio Waheed, Maryam Nana Musa, Timothy God-Giveth Olusegun, Ayomide Babatunde Ishola, Agumage Idoko, Adeola Victor Kolawole, Adesanmi Adefunmilayo Oluwatuyi, Sarah Ngozi Agwasim
Phytochemical Analysis, Antioxidant, And Antibacterial Properties Of Partition Fractions Of Adansonia Digitata And Annona Muricata Extracts Using Chloroform, Ethyl Acetate, Ethanol, And Aqueous Solvent Systems, Fagbohun Oyenike Bushirat, Hassan Abdusalam Adewuyi, Sakariyau Adio Waheed, Maryam Nana Musa, Timothy God-Giveth Olusegun, Ayomide Babatunde Ishola, Agumage Idoko, Adeola Victor Kolawole, Adesanmi Adefunmilayo Oluwatuyi, Sarah Ngozi Agwasim
Chemistry & Biochemistry Faculty Publications
Adansonia digitata and Annona muricata are traditionally used medicinal plants with reported pharmacological properties. In this study, we aimed to elucidate the phytochemical composition, antioxidant activity, and antibacterial properties of partition fractions of Adansonia digitata and Annona muricata extracts obtained using chloroform, ethyl acetate, ethanol, and aqueous solvent systems. The plant extracts were successively partitioned using chloroform, ethyl acetate, ethanol, and aqueous solvent systems. Phytochemical analysis was performed using standard methods. Antioxidant activity was evaluated using FRAP and DPPH assays. Antibacterial activity was assessed using agar well diffusion and MIC determination. Phytochemical analysis revealed the presence of alkaloids (10.2-15.6%), flavonoids …
Evaluating The Chemical Reactivity Of Wildfire-Derived Dissolved Organic Molecules: Glutathione Binding Through Kendrick Mass Defect Analysis, Hannah M. Hamontree, Patrick G. Hatcher
Evaluating The Chemical Reactivity Of Wildfire-Derived Dissolved Organic Molecules: Glutathione Binding Through Kendrick Mass Defect Analysis, Hannah M. Hamontree, Patrick G. Hatcher
Chemistry & Biochemistry Faculty Publications
The emerging risks to organisms of pyrogenic-derived dissolved organic matter (PyDOM) from forest fires are of concern due to its toxic and mutagenic potential (e.g., pro-oxidative responses in fauna through the depletion of glutathione, a nitrogen- and sulfur-containing tripeptide found in cells). This study simulates this phenomenon in a laboratory setting by identifying bonding between reduced l-glutathione and organic molecules in leachates from environmentally weathered biomass samples (charred and uncharred) using Kendrick Mass Defect (KMD) analysis from formula lists obtained from negative-mode electrospray ionization-Fourier transform-ion cyclotron resonance-mass spectrometry ((-)ESI-FT-ICR-MS). These formula lists reveal a 10-fold increase in nitrogen- and sulfur-containing …
From Biophysics To Cellular Function: Neural Telcs-Membrane-Anions Capacitor Transmembrane Potential, James Weifu Lee
From Biophysics To Cellular Function: Neural Telcs-Membrane-Anions Capacitor Transmembrane Potential, James Weifu Lee
Chemistry & Biochemistry Faculty Publications
Based on the transmembrane-electrostatically localized protons/cations charges (TELCs) theory, neural transmembrane potential including both resting and action potential is now well elucidated as the voltage contributed by the TELCs-membrane-anions capacitor biophysics in a neuron. Accordingly, neural transmembrane potential has an inverse relationship with TELCs surface density, which may represent a substantial progress in bettering the fundamental understanding of neuroscience. In this article, I will present a review on the latest development of the TELCs neural transmembrane potential theory and address Silverstein’s interesting arguments regarding the TELCs model that may constitute a complementary development to both the Hodgkin-Huxley classic cable theory …
The Importance Of Solution Studies For The Structural Characterization Of The Enterovirus 5' Cloverleaf, Morgan G. Daniels, Meagan E. Werner, Xiaobing Zuo, Steven M. Pascal
The Importance Of Solution Studies For The Structural Characterization Of The Enterovirus 5' Cloverleaf, Morgan G. Daniels, Meagan E. Werner, Xiaobing Zuo, Steven M. Pascal
Chemistry & Biochemistry Faculty Publications
Enteroviruses initiate genomic replication via a highly conserved mechanism that is controlled by an RNA platform, also known as the 5' cloverleaf (5'CL). Here, we present a biophysical analysis of the 5'CL conformation of three enterovirus serotypes under various ionic conditions, utilizing CD spectroscopy, size-exclusion chromatography, and small-angle X-ray scattering. In general, a tendency toward a smaller monomeric hydrodynamic radius in the presence of salts was observed, but the exact structural signature of each 5'CL varied depending upon the serotype. Rhinovirus B14 (RVB14) exhibited at least two monomeric conformations and a low propensity for dimerization, while poliovirus 1 (PV1) showed …
Nucleotide-Derived Bacterial Alarmones Attenuate The Induction Of Type-I Interferon Responses In A Murine Macrophage Reporter Cell Line, Ryan P. Kilduff, Erin B. Purcell, Lisa M. Shollenberger
Nucleotide-Derived Bacterial Alarmones Attenuate The Induction Of Type-I Interferon Responses In A Murine Macrophage Reporter Cell Line, Ryan P. Kilduff, Erin B. Purcell, Lisa M. Shollenberger
Chemistry & Biochemistry Faculty Publications
The stringent response is a well-studied phenomenon in many bacterial systems and regulates resource-consuming activities such as transcription, translation, and replication. The stringent response is a well-conserved signaling framework, as are the nucleotide-derived signaling mediators, collectively referred to as (p)ppGpp or as alarmones. There is a wealth of research evaluating nucleotide-derived alarmone signaling in bacterial models, however, their potential to modulate innate immune signaling has not yet been evaluated. Several common pathogen-synthesized molecules, such as lipopolysaccharide (LPS) and cyclic-di-AMP (c-di-AMP), act as pathogen-associated molecular patterns (PAMPs), which are common patterns that alert the innate immune system of bacterial infection. The …
Application Of Telc Model To Better Elucidate Neural Stimulation By Touch, James Weifu Lee
Application Of Telc Model To Better Elucidate Neural Stimulation By Touch, James Weifu Lee
Chemistry & Biochemistry Faculty Publications
Aim: This study is to better understand how the transient ion transport activity of touch receptors could change the graded potential to stimulate an action potential firing.
Methods: The latest transmembrane-electrostatically localized protons/cations charges (TELC) theory is employed for numerical analysis to calculate the neural touch signal transduction responding time required to fire an action potential spike.
Results: A neural action potential spike was constructed successfully using newly developed time-dependent TELC-based neural transmembrane potential integral equations (Equations 5, 6, and 7). The results explicated that the TELC curve has an inverse relationship with neural transmembrane potential since its curve appears …
Extended Inter-Laboratory Characterization Of The New Coastal Seawater Dissolved Organic Matter Reference Material Trm-0522, Alexander J. Craig, Lydia Babcock-Adams, Maxime C. Bridoux, Charlotte Brun, Juliana D'Andrilli, Aleksandar I. Goranov, Patrick G. Hatcher, Oliver Lechtenfeld, Hang Li, Rebecca Matos, Garrett Mckay, Amy M. Mckenna, Madelyn Miller, Sasha Wagner, Margot E. White, Alexander Zherebker, Jeffrey A. Hawkes
Extended Inter-Laboratory Characterization Of The New Coastal Seawater Dissolved Organic Matter Reference Material Trm-0522, Alexander J. Craig, Lydia Babcock-Adams, Maxime C. Bridoux, Charlotte Brun, Juliana D'Andrilli, Aleksandar I. Goranov, Patrick G. Hatcher, Oliver Lechtenfeld, Hang Li, Rebecca Matos, Garrett Mckay, Amy M. Mckenna, Madelyn Miller, Sasha Wagner, Margot E. White, Alexander Zherebker, Jeffrey A. Hawkes
Chemistry & Biochemistry Faculty Publications
Dissolved organic matter (DOM) reference materials are critical to ensuring reliable comparability of measurements across experiments and between labs. TRM-0522, isolated in 2022 from 45 m deep seawater off of Sweden’s west coast, fills the niche of a previously unavailable coastal marine DOM reference material. After its isolation, we detailed a limited number of metrics for TRM-0522, initially disclosing Orbitrap high-resolution mass spectrometry, nuclear magnetic resonance, carbon proportion, absorbance, and fluorescence data. With TRM-0522 becoming more widely used, a variety of labs have generated different metrics that help to characterize and define the chemical properties of this coastal reference material. …
Experimental Demonstration And Study Of Transmembrane-Electrostatically Localized Protons Prevail, James Weifu Lee
Experimental Demonstration And Study Of Transmembrane-Electrostatically Localized Protons Prevail, James Weifu Lee
Chemistry & Biochemistry Faculty Publications
In this review in relation to some interesting arguments from Silverstein, it is now reaffirmed that the experimental demonstration of transmembrane-electrostatically localized protons (TELPs) was successfully accomplished through 1) using an aluminum film as a TELPs sensor in a biomimetic anode water-membrane-water cathode system, 2) analyzing the water-electrolysis current curve, and 3) measuring bulk liquid phase pH. Formation of induced TELPs was subsequently discovered in an anode water-membrane-water-membrane-water cathode system. The discovery of induced TELPs enabled clean experimental tests on the cation-TELPs exchange process by using sodium bicarbonate or potassium bicarbonate solution in the central liquid chamber. The sodium/TELPs exchange …
General Kernel Machine Methods For Multi-Omics Integration And Genome-Wide Association Testing With Related Individuals, Amarise Little, Ni Zhao, Anna Mikhaylova, Angela Zhang, Wodan Ling, Florian Thibord, Andrew D. Johnson, Laura M. Raffield, Joanne E. Curran, John Blangero
General Kernel Machine Methods For Multi-Omics Integration And Genome-Wide Association Testing With Related Individuals, Amarise Little, Ni Zhao, Anna Mikhaylova, Angela Zhang, Wodan Ling, Florian Thibord, Andrew D. Johnson, Laura M. Raffield, Joanne E. Curran, John Blangero
School of Medicine Publications
Integrating multi-omics data may help researchers understand the genetic underpinnings of complex traits and diseases. However, the best ways to integrate multi-omics data and use them to address pressing scientific questions remain a challenge. One important and topical problem is how to assess the aggregate effect of multiple genomic data types (e.g. genotypes and gene expression levels) on a phenotype, particularly while accommodating routine issues, such as having related subjects' data in analyses. In this paper, we extend an existing composite kernel machine regression model to integrate two multi-omics data types, while accommodating for general correlation structures amongst outcomes. Due …
Investigating Dimensions Of Social Vulnerability To Wildfire: A Case Study Of Western Montana, Ella Brodowski
Investigating Dimensions Of Social Vulnerability To Wildfire: A Case Study Of Western Montana, Ella Brodowski
Dissertations, Master's Theses and Master's Reports
Communities across the US are facing increased wildfire risks due in part to historic fire suppression efforts, a warming climate, and an influx of people residing in wildland urban interface (WUI) landscapes. Because of these increasing risks, there have been growing concerns about the social factors that can increase individual and community vulnerability to wildfires. This research adds to the discussion of social vulnerability by examining how people living in a geographic area with heightened wildfire risk think about the ways in which people can be more or less vulnerable to wildfires. Using semi-structured interviews, round table discussions, and field …
Relict Ponderosa Pine Mortality And Fuels Study In The Bob Marshall Wilderness, Montana, Usa, Laura K. Schimmel
Relict Ponderosa Pine Mortality And Fuels Study In The Bob Marshall Wilderness, Montana, Usa, Laura K. Schimmel
Dissertations, Master's Theses and Master's Reports
Many forests have historically experienced mixed-severity fire regimes that were disrupted during the 20th century due to fire exclusion policy. A stand of relict Pinus ponderosa in the Bob Marshall Wilderness Complex that burned in 2003, 2011, and 2018 provides a unique case study for investigating the effects of returned fire to the landscape. Many of the trees have fire scars or Indigenous bark-peeling scars, preserving valuable ecological and anthropological history. We sought to determine whether scarred trees were more susceptible to fire damage, if larger trees had greater fire resilience than smaller trees, and if fuel loads have changed …
Computational Tools For Protein Classification In Metagenomes, Fawad Ullah
Computational Tools For Protein Classification In Metagenomes, Fawad Ullah
Dissertations, Master's Theses and Master's Reports
Advances in genomic sequencing have dramatically increased the amount and the speed at which genomic data is being generated. These technological advances have enabled the ability to profile the genetic information of organisms and communities at unprecedented scales. Many methods have been developed to identify and classify genes within these datasets. However, many generic pipelines for gene annotation struggle to accurately predict specific protein classes that may not be represented in their databases. Two major challenges exist for classification of specific protein classes in metagenomic databases. The first is the fact that many metagenomic assemblies are highly fragmented with many …
Sugar Maple (Acer Saccharum Marsh.) Tree-Ring Growth And Carbon Stable Isotope Responses To Nitrogen And Climate, Libbie Ring
Sugar Maple (Acer Saccharum Marsh.) Tree-Ring Growth And Carbon Stable Isotope Responses To Nitrogen And Climate, Libbie Ring
Dissertations, Master's Theses and Master's Reports
This dendrochronological and stable carbon isotope study used tree rings from sugar maple (Acer Saccharum Marsh.) collected at long-term nitrogen (N) amended sites throughout Michigan to understand N amendment and deposition, climate, and growth relationships. Climate responses varied by site, however, we found importance in grouping sites by “productivity” which is related to inherent N and soil nutrients. Our results did not detect an overall effect of N amendments on growth during the treatment period. However, data shows N amendments benefiting larger diameter trees, while smaller diameter trees responded more positively without amendments, especially on more productive sites. Results …
Phytoremediation Potential Of Pot Marigold (Calendula Officinalis L.) Under Plant Growth-Promoting Rhizobacteria (Pgpr) Treatments For Sustainable Urban Green Infrastructure Development, Fatemeh Kazemi, Mansoure Jozay
Phytoremediation Potential Of Pot Marigold (Calendula Officinalis L.) Under Plant Growth-Promoting Rhizobacteria (Pgpr) Treatments For Sustainable Urban Green Infrastructure Development, Fatemeh Kazemi, Mansoure Jozay
Research outputs 2022 to 2026
This study evaluated the phytoremediation potential of pot marigolds on green wall systems for removing soil cadmium. The experiment was a factorial arrangement in a randomized complete block design. The first factor was cadmium (0, 1, 2, and 3 mg/kg soil), and the second was seven single or mixed plant growth-promoting rhizobacteria (PGPR) and the control treatments. All root and flower-related traits significantly increased after bacterial treatments (p ≤ 0.05). Substrates inoculated with Thiobacillus thioparus strain 300, Mix2 (Aztobactor chorococcum strain D0941 + Azosporillum liposferum strain So131), and Mix3 (Thiobacillus thioparus strain 300+ Pseudomonas putida strain G0951+ Aztobactor chorococcum strain …
Joint Estimation Of Paternity, Sibships And Pollen Dispersal In A Snapdragon Hybrid Zone, Thomas James Ellis, David Luke Field, Nicholas H. Barton
Joint Estimation Of Paternity, Sibships And Pollen Dispersal In A Snapdragon Hybrid Zone, Thomas James Ellis, David Luke Field, Nicholas H. Barton
Research outputs 2022 to 2026
Inferring genealogical relationships of wild populations is useful because it gives direct estimates of mating patterns and variance in reproductive success. Inference can be improved by including information about parentage shared between siblings, or by modelling phenotypes or population data related to mating. However, we currently lack a framework to infer parent–offspring relationships, sibships and population parameters in a single analysis. To address this, we here extend a previous method, Fractional Analysis of Paternity and Sibships, to include population data for the case where one parent is known. We illustrate this with the example of pollen dispersal in a natural …
Varying Vulnerabilities: Seagrass Species Under Threat From Prolonged Ocean Warming, Marnie L. Campbell, Chi T.U. Le
Varying Vulnerabilities: Seagrass Species Under Threat From Prolonged Ocean Warming, Marnie L. Campbell, Chi T.U. Le
Research outputs 2022 to 2026
Understanding the response of various seagrass species to prolonged elevated water temperatures is crucial for effective management and seagrass species restoration amid increasing climate change-induced ocean warming and marine heat waves. This is especially important in intertidal seagrass meadows, where heat can penetrate substrate depths of up to 50 cm. We assessed and contrasted the responses of five intertidal species—Zostera muelleri Irmisch ex Asch, Halophila ovalis (R.Br.) Hook f., Halodule uninervis (Forssk.) Asch, Halophila decipiens Ostenf., and Halophila spinulosa (R.Br.) Asch—over a month of elevated temperatures by examining rhizome growth, number of living shoots, root development, and sprig survival. While …
Seasonal Variability Of Surface Ocean Carbon Uptake And Chlorophyll-A Concentration In The West Antarctic Peninsula Over Two Decades, Jessica S. Turner, David R. Munro, Amanda Fay, Sharon Stammerjohn, Heather Kim, Oscar Schofield, Heidi Dierssen
Seasonal Variability Of Surface Ocean Carbon Uptake And Chlorophyll-A Concentration In The West Antarctic Peninsula Over Two Decades, Jessica S. Turner, David R. Munro, Amanda Fay, Sharon Stammerjohn, Heather Kim, Oscar Schofield, Heidi Dierssen
OES Faculty Publications
The Southern Ocean plays a vital role in global CO₂ uptake, but the magnitude and even the sign of the flux remain uncertain, and the influence of phytoplankton phenology is underexplored. This study focuses on the West Antarctic Peninsula, a region experiencing rapid climate change, to examine shifts in seasonal carbon uptake. Using 20 years of in situ air-sea CO₂ flux and satellite-derived Chlorophyll-a, we observe that the seasonal cycles of both air-sea CO₂ flux and Chlorophyll-a intensify poleward. The amplitude of the seasonal cycle of the non-thermal component of surface ocean pCO₂ increases with increasing latitude, while the amplitude …
Pygoscelis Penguins Prefer Different Oceanographic And Terrestrial Habitats During The Austral Summer, Katherine L. Gallagher, Rachel Herman, Katherine Walton, Michael S. Dinniman, Heather J. Lynch
Pygoscelis Penguins Prefer Different Oceanographic And Terrestrial Habitats During The Austral Summer, Katherine L. Gallagher, Rachel Herman, Katherine Walton, Michael S. Dinniman, Heather J. Lynch
OES Faculty Publications
Pygoscelis penguins interact with both terrestrial and marine environments, especially during the austral summer when they raise their chicks. Accessible ice-free ground spaces serve as locations for penguins to build colonies and successfully raise chicks while the surrounding marine environment serves as the foraging grounds for adult birds. Penguins must be able to navigate through the waters around their colonies to forage for Antarctic krill (Euphausia superba), their primary prey during the austral summer. Krill, whose distributions are driven partially by the surrounding physics and partially by their behaviors, must also be plentiful in the waters near the …
Investigating The Human Face Processing Network: Insights From Acquired Prosopagnosia And Hyperfamiliarity For Faces, Marie-Luise Kieseler
Investigating The Human Face Processing Network: Insights From Acquired Prosopagnosia And Hyperfamiliarity For Faces, Marie-Luise Kieseler
Dartmouth College Ph.D Dissertations
Human faces provide essential social cues that we interpret rapidly, allowing us to recognize identities, interpret emotions, and gauge familiarity. This thesis explores face processing disruptions in four case studies, each offering new insights into the brain’s face recognition mechanisms.
Chapter one presents Annie, a 28-year-old woman who acquired prosopagnosia (face blindness) following COVID-19. After recovering from the severe symptoms of the infection, Annie experienced significant difficulty in recognizing familiar faces and navigating familiar environments. Testing confirmed her impairment in face recognition but showed her preserved cognitive and basic visual processing abilities. Annie was still able to recognize objects and …
Cell Competition Eliminates Aneuploid Human Pluripotent Stem Cells, Amanda I. Ya
Cell Competition Eliminates Aneuploid Human Pluripotent Stem Cells, Amanda I. Ya
Dartmouth College Ph.D Dissertations
Aberrant mitotic chromosome segregation results in the generation of cells with aneuploidy, an incorrect number of chromosomes. Aneuploidy can compromise the viability of the developing embryo and is the leading cause of pregnancy loss, failed embryo implantation, and congenital birth defects. Yet, widescale analysis of human embryos from in vitro fertilization (IVF) clinics suggests that aneuploidy is common, with upwards of 70% of preimplantation embryos being aneuploid.
Mitotic chromosome missegregation during post-zygotic development results in mosaic embryos made up of both diploid and aneuploid cells. Strikingly, upon transplant for pregnancy, mosaic embryos have been reported to result in healthy birth …
Of Mice And Men: The Regulation Of Herpes Simplex Virus 1 Latency In Mouse And Human Neurons, Paige N. Canova
Of Mice And Men: The Regulation Of Herpes Simplex Virus 1 Latency In Mouse And Human Neurons, Paige N. Canova
Dartmouth College Ph.D Dissertations
Herpes simplex virus 1 (HSV-1) establishes latent infections in sensory neurons, from which HSV sporadically reactivates, often due to external stress and other stimuli. Latency and reactivation are commonly studied using in vivo and ex vivo models in a variety of hosts, as well as in vitro models including primary mouse neurons and neurons derived from human pluripotent stem cells (iPSCs). The criteria for authentically modeling HSV latency include the ability to easily manipulate host genetics and biological pathways, as well as mimicking the immune response and viral pathogenesis in human infections. Presently, there remains a pressing need for …
Leveraging Epigenomics And Transcriptomics To Develop High-Dimensional Biomarkers Of Neuroinflammation, Steven C. Pike
Leveraging Epigenomics And Transcriptomics To Develop High-Dimensional Biomarkers Of Neuroinflammation, Steven C. Pike
Dartmouth College Ph.D Dissertations
Neuroinflammation is a critical physiological phenomenon implicated in most neurological disorders, either as a cause or a consequence of pathology. Our understanding of neuroinflammation is limited by the inability to directly profile the cells of interest. Thus, developing biomarkers of neuroinflammation is clinically urgent as we know neuroinflammation correlates with patient outcomes and treatment success. The recent advances in “omics” technologies, particularly epigenomics and transcriptomics, provides the opportunity for high-dimensional profiling of biospecimens for potential biomarkers. Within this dissertation, I demonstrate that biomarkers obtained from “omics” platforms can detect neuroimmunological phenomena in clinical and preclinical settings. In chapter one, DNA …
Characterization Of The Erv41-Erv46 Complex As A Retrograde Receptor For Misfolded Secretory Proteins, John Andrew Fuesler
Characterization Of The Erv41-Erv46 Complex As A Retrograde Receptor For Misfolded Secretory Proteins, John Andrew Fuesler
Dartmouth College Ph.D Dissertations
The Endoplasmic Reticulum (ER), the site of secretory protein biosynthesis
provides a favorable environment to promote polypeptide folding, protein
oligomerization and export. Although the ER contains many chaperones and other
factors that assist in protein folding, this process is error prone. Eukaryotes have
evolved protein quality control checkpoints to maintain homeostasis in the secretory
pathway, however these processes are imperfect and may result in proteotoxicity
when toxic levels or aggregates of proteins arise. Mutations in proteins involved in
trafficking in the early secretory pathway are closely associated with disease states.
Therefore, it is of great interest to further understand how …
Engineering Extracellular Vesicles (Evs) To Combat Infection And Inflammation In Cystic Fibrosis, Sharanya Sarkar
Engineering Extracellular Vesicles (Evs) To Combat Infection And Inflammation In Cystic Fibrosis, Sharanya Sarkar
Dartmouth College Ph.D Dissertations
Cystic Fibrosis (CF) is a multisystemic genetic disorder caused by mutations in the CFTR gene, resulting in chronic pulmonary infections, hyperinflammation, and progressive lung damage. Among the pathogens that colonize CF lungs, Pseudomonas aeruginosa (P. aeruginosa) is predominant, infecting over 50% of adults with CF and developing antibiotic resistance over time. Current modulator therapies fail to address persistent bacterial infections, chronic inflammation, or irreversible lung damage, underscoring the need for novel therapeutic strategies. In our previous in vitro studies, we demonstrated that extracellular vesicles (EVs) secreted by primary Human Bronchial Epithelial Cells (HBECs) inhibit P. aeruginosa growth by reducing the …
Biochemical And Molecular Analysis Of Anr-Dependent Microoxic Fitness Factors In Pseudomonas Aeruginosa, Stacie E. Balsam
Biochemical And Molecular Analysis Of Anr-Dependent Microoxic Fitness Factors In Pseudomonas Aeruginosa, Stacie E. Balsam
Dartmouth College Ph.D Dissertations
Pseudomonas aeruginosa is a prominent opportunistic pathogen that is often found in microoxic environments like sites of infection and colony biofilms. P. aeruginosa can grow at oxygen (O2) at concentrations as little as 3 μM and also grows anaerobically by generating energy using nitrate as an alternate electron acceptor. An important way P. aeruginosa adapts to low O2 is through Anr, a transcription factor that upregulates many genes important for microoxic and anoxic fitness.
Specifically, Anr regulates mhr which encodes a hemerythrin protein (Mhr) that binds O2 with affinities relevant to microoxia and is also necessary for full fitness of …
A Transferable Approach For Quantifying Benthic Fish Sizes And Densities In Annotated Underwater Images, Peter C. Esselman, Shadi Moradi, Joseph K. Geisz, Christopher Roussi
A Transferable Approach For Quantifying Benthic Fish Sizes And Densities In Annotated Underwater Images, Peter C. Esselman, Shadi Moradi, Joseph K. Geisz, Christopher Roussi
Michigan Tech Publications
Benthic fishes are a common target of scientific monitoring but are difficult to quantify because of their close association to bottom habitats that are hard to access. Advances in image-acquisition technologies, machine vision and deep learning have made capturing and quantifying fishes with cameras increasingly feasible. We present a method and open-source software called ‘FishScale’ to estimate benthic fish lengths, numeric abundance and biomass density in underwater environments assessed with down-looking monocular images. ‘FishScale’ estimates fish abundances and size frequencies from near-nadir monocular images where fish have already been semantically segmented. The software accounts for lens distortion, underwater magnification effects …