Life Sciences Commons^™

Recurrent And Metastatic Head And Neck Cancer: Mechanisms Of Treatment Failure, Treatment Paradigms, And New Horizons, William T. Barham, Marshall Patrick Stagg, Rula Mualla, Michael Dileo, Sagar Kansara

School of Medicine Faculty Publications

Background: Head and neck cancer is a deadly disease with over 500,000 cases annually worldwide. Metastatic head and neck cancer accounts for a large proportion of the mortality associated with this disease. Many advances have been made in our understanding of the mechanisms of metastasis. The application of immunotherapy to locally recurrent or metastatic head and neck cancer has not only improved oncologic outcomes but has also provided valuable insights into the mechanisms of immune evasion and ultimately treatment failure. Objectives: This review paper will review our current understanding of biological mechanisms of treatment failure and metastasis. Published and ongoing …

Dietary Program For The Reduction Of Type 2 Diabetes Prevalence In A South Texas Border Region, Siddiqua Noor

Doctor of Nursing Practice Final Project Abstract

PURPOSE The purpose of this project was to create a culturally sensitive dietary program template to serve as a guide to offer healthier food alternatives to reduce the incidence of type 2 diabetes while not compromising on their Hispanic heritage.

BACKGROUND This project was implemented in a South Texas border community which has nearly twice the national average of Type 2 Diabetes Mellitus, which presents a significant public health challenge.

METHODOLOGY The project followed the Plan-Do-Study-Act cycle and incorporated the Health Belief Model. A dietary pamphlet featuring local culturally relevant food options was developed. The material was presented at two …

Exploring The Potential Of Malvidin And Echiodinin As Probable Antileishmanial Agents Through In Silico Analysis And In Vitro Efficacy, Luis Daniel Goyzueta-Mamani, Daniela Pagliara Lage, Haruna Luz Barazorda-Ccahuana, Margot Paco-Chipana, Mayron Antonio Candia-Puma, Gonzalo Davila-Del-Carpio, Alexsandro Sobreira Galdino, Ricardo Andrez Machado-De-Avila, Rodolfo Cordeiro Giunchetti, Edward L. D'Antonio, Eduardo Antonio Ferraz Coelho, Miguel Angel Chávez-Fumagalli

Natural Sciences Faculty Publications

Leishmaniasis, a neglected tropical disease caused by Leishmania species, presents serious public health challenges due to limited treatment options, toxicity, high costs, and drug resistance. In this study, the in vitro potential of malvidin and echioidinin is examined as antileishmanial agents against L. amazonensis, L. braziliensis, and L. infantum, comparing their effects to amphotericin B (AmpB), a standard drug. Malvidin demonstrated greater potency than echioidinin across all parasite stages and species. Against L. amazonensis, malvidin’s IC50 values were 197.71 ± 17.20 μM (stationary amastigotes) and 258.07 ± 17 μM (axenic amastigotes), compared to echioidinin’s 272.99 ± 29.90 μM and 335.96 …

Course Portfolio: Bios 443/843 Immunology, Nicole Sexton

UNL Faculty Course Portfolios

This course portfolio relates to the Fall 2025 delivery of BIOS 443/843: Immunology, cross listed as MBIO 443 and VMBS 843 and was prepared as part of the Faculty-led Inquiry into Reflective and Scholarly Teaching (FIRST) project. BIOS 443/843 is an upper division course that introduces Immunological concepts but also connects them to up to date literature in the field of Immunology with the intent of preparing students for careers in medicine and biomedical research. In Fall of 2025 this course was restructured to incorporate additional peer-to-peer learning opportunities and more distributed assessment styles, therefore was peer-reviewed to assess the …

Couple-Based Lifestyle Intervention For Minority Prostate Cancer Survivors: A Randomized Feasibility Trial, Dalnim Cho, Yisheng Li, Karen Basen-Engquist, Chiara Acquati, Nga T T Nguyen, Curtis A Pettaway

Faculty, Staff and Student Publications

Background: Black and Hispanic prostate cancer (PCa) survivors, who face a high burden of comorbid conditions and often engage in low levels of physical activity and healthy eating, remain significantly underrepresented in lifestyle intervention studies.

Purpose: Given the significance of spousal influence, we developed a culturally tailored lifestyle intervention for these survivors and their spouses and assessed its feasibility, acceptability, and impact on behavioral change.

Methods: Survivor-spouse couples were randomly assigned to an intervention group (n = 22), which received 12 health-coaching calls over 6 months, or a usual-care control group (n = 9). Assessments were conducted at baseline (T1), …

Cyclin E1/Cdk2 Activation Defines A Key Vulnerability To Wee1 Kinase Inhibition In Gynecological Cancers, Daehwan Kim, Heekyung Chung, Wen Liu, Kangjin Jeong, Tugba Y Ozmen, Matthew J Rames, Xiao Guo, Nathan Jameson, Petrus R De Jong, Steven Yea, Laurie Harford, Jiali Li, Cara A Mathews, Deborah B Doroshow, Vincent J Charles, Doris Kim, Kimberlee Fischer, Ahmed A Samatar, Adrian Jubb, Kevin D Bunker, Kimberly Blackwell, Fiona Simpkins, Funda Meric-Bernstam, Gordon B Mills, Olivier Harismendy, Jianhui Ma, Mark R Lackner

Faculty, Staff and Student Publications

Upregulation of Cyclin E1 and subsequent activation of CDK2 accelerates cell cycle progression from G1 to S phase and is a common oncogenic driver in gynecological malignancies. WEE1 kinase counteracts the effects of Cyclin E1/CDK2 activation by regulating multiple cell cycle checkpoints. Here we characterized the relationship between Cyclin E1/CDK2 activation and sensitivity to the selective WEE1 inhibitor azenosertib. We found that ovarian cancer cell lines with high levels of endogenous Cyclin E1 expression or forced overexpression were exquisitely sensitive to azenosertib and these results extended to in vivo models of ovarian and uterine serous carcinoma. Models with high Cyclin …

Early Treatment Discontinuation In Patients With Deficient Mismatch Repair Or Microsatellite Instability High Metastatic Colorectal Cancer Receiving Immune Checkpoint Inhibitors, Julien Taieb, Margherita Ambrosini, Emily Alouani, Sara Lonardi, Frank A Sinicrope, Alice Boileve, Thibault Mazard, Simon Pernot, Pauline Parent, Javier Ros, Michael J Overman, Priya Jayachandran, Vincenzo Nasca, Lisa Salvatore, Rosine Guimbaud, Chiara Cremolini, David Tougeron, Filippo Pietrantonio

Faculty, Staff and Student Publications

Background: Immune checkpoint inhibitors (ICIs) are recommended to treat patients with deficient mismatch repair/microsatellite instability high (dMMR/MSI-H) metastatic colorectal cancer (mCRC). Pivotal trials have fixed a maximum ICI duration of 2 years, without a compelling rationale. A shorter treatment duration has the potential to improve patients' quality of life and reduce both toxicity and cost without compromising efficacy. Here we examine whether early treatment discontinuation (ETD) before 13 months in patients without progressive disease (PD) can lead to similar long-term disease control compared with a longer treatment duration (LTD).

Methods: To assess whether ETD is associated with similar outcomes compared …

Effect Of Feeding Fenugreek Extract And Encapsulated Lecithin On Finishing Cattle Performance, Carcass Characteristics, And Liver Abscesses, Sofia Suarez Lorences, Rebecca L. Mcdermott, Joshua R. Benton, Robert Bondurant, Willard Lemaster, James C. Macdonald, Galen E. Erickson

Nebraska Beef Cattle Reports

Summary with Implications

A feedlot study was conducted to evaluate the effects of adding fenugreek extract and encapsulated lecithin (Furst-McNess Company, Rockford, Illinois, United States) on finishing cattle performance, carcass characteristics, and liver abscesses. Treatments were applied as a 2×2 factorial that included a control diet with no additive; a diet containing fenugreek extract; a diet containing encapsulated lecithin; and a diet containing both fenugreek extract and encapsulated lecithin. Tylosin was not included in any diets to test natural occurrence of liver abscesses. No interactions were observed between fenugreek extract and encapsulated lecithin treatments but neither feed additive impacted intakes, …

Effects Of Allocation Frequency On Cattle Performance And Forage Utilization When Swath Grazing A Sorghum-Sudangrass Hybrid In Eastern Nebraska, Thomas E. Aquino, Mary E. Drewnoski, Pedro Henrique J. Fernandes

Nebraska Beef Cattle Reports

Summary with Implications

A sorghum-sudangrass hybrid was swath grazed by growing steers (529 ± 18 lb) from November 2023 to January 2024. Treatments were offering new forage once (1X) or twice (2X) per week to determine the effect of allocation frequency on animal performance and forage utilization. Average daily gain was not impacted by treatment (1X = 0.45 ± 0.1 lb/day, 2X = 0.45 ± 0.1 lb/day). Pre-and post-graze biomass samples were collected to estimate forage utilization, which was not different between treatments (1X = 57.1 ± 3.6%, 2X = 61.1 ± 3.6%). However, there was a difference in carrying …

How Eye See, Now I See, Michael Anthony Simon

Theses and Dissertations

Michael Anthony Simon’s paper addresses ideas surrounding the fluid nature of perception, time, and ideas of control, or lack there-of. Creating a symbolic relationship between paintings and sculpture. Simon both embraces and confuses the notion that understanding is never truly stable or secure.

Spatiotemporal Synchrony Of Climate And Fire Occurrence Across North American Forests (1750–1880), Ellis Margolis, Andreas Wion, John Abatzoglou, Lori Daniels, Donald Falk, Chris Guiterman, James Johnston, Kurt Kipfmueller, Charles Lafon, Rachel Loehman, Maggie Lonergan, Cameron Naficy, Marc-André Parisien, Sean Parks, Jeanne Portier, Michael Stambaugh, Ellen Whitman, A. Park Williams, Larissa Yocom

Wildland Resources Faculty Publications

Aim: Increasing aridity has driven widespread synchronous fire occurrence in recent decades across North America. The lack of historical (pre-1880) fire records limits our ability to understand long-term continental fire-climate dynamics. The goal of this study is to use tree-ring reconstructions to determine the relationships between spatiotemporal patterns in historical climate and widespread fire occurrence in North American forests, and whether they are stable through time. This information will address a major knowledge gap required to inform projections of future fire.

Location: North American Forests.

Time Period: 1750–1880 CE.

Major Taxa Studied: Trees.

Methods: We applied regionalisation methods to tree-ring …

Identifying Personality In Reptiles And Assessing Welfare Implications For Their Roles As Ambassador Animals In An Educational Setting, Valery Gonzalez

Theses and Dissertations

This study examined behavioral variability and personality in 13 reptiles used as ambassador animals at the American Museum of Natural History. Observations across seasons and novel object tests revealed individual differences, behavioral components, and correlations. Findings emphasize reptilian complexity, highlighting welfare implications while underscoring the need for further research.

Forest Above-Ground Biomass Estimation Using Nasa Gedi Lidar Waveforms And Global Tree Allometry, Ian Grant

Theses and Dissertations

Above-ground forest biomass plays a crucial role in global carbon cycles, yet accurately estimating biomass at global scales remains challenging. This thesis addresses two key challenges in processing NASA’s Global Ecosystem Dynamics Investigation (GEDI) space-borne lidar data to estimate above-ground biomass density (AGBD): accounting for global variation in forest structure and developing robust physical interpretations of lidar returns. The first component of the thesis analyzes global patterns of tree allometry using the Tallo tree allometry dataset, examining relationships between tree dimensions across biomes, continents, and plant functional types. This analysis reveals consistent allometry across continents for some biomes (e.g., tropical …

Social Networks And Behavioral Adaptation Of Serrano Horses In A Rewilding Initiative In Spain, Ashley Bruno

Theses and Dissertations

Rewilding is a conservation measure that involves actively relocating species or restricting human land use to improve ecosystem sustainability. However, critics raise concerns that rewilding privileges ecosystem function over endangered species. Due to a lack of monitoring around species’ relocations, uncertainty lies in ecological outcomes and psychological, social, cultural impacts on affected animals. For this project, we collaborated with the non-profit Rewilding Europe that sought to conserve Serrano horses (Equus caballus), an ancient and under-studied breed of Spanish horse by relocating 11 individuals to a protected site in Guadalajara, Spain in June 2022. Our research aimed to address …

Land Use Change Consistently Reduces Α- But Not Β- And Γ-Diversity Of Bees., Toby P N Tsang, A A Amado De Santis, Gabriela Armas-Quiñonez, John S Ascher, Eva Samanta Ávila-Gómez, András Báldi, Kimberly M Ballare, Mario V Balzan, Weronika Banaszak-Cibicka, Svenja Bänsch, Yves Basset, Adam J Bates, Jessica M Baumann, Mariana Beal-Neves, Ashley Bennett, Antonio Diego M Bezerra, Betina Blochtein, Riccardo Bommarco, Berry Brosi, Laura A Burkle, Luísa G Carvalheiro, Ignacio Castellanos, Marcela Cely-Santos, Hamutahl Cohen, Drissa Coulibaly, Saul A Cunningham, Sarah Cusser, Isabelle Dajoz, Deborah A Delaney, Ek Del-Val, Monika Egerer, Markus P Eichhorn, Eunice Enríquez, Martin H Entling, Natalia Escobedo-Kenefic, Pedro Maria Abreu Ferreira, Gordon Fitch, Jessica R K Forrest, Valérie Fournier, Robert Fowler, Breno M Freitas, Hannah R Gaines-Day, Benoît Geslin, Jaboury Ghazoul, Paul Glaum, Jose L Gonzalez-Andujar, Adrian González-Chaves, Heather Grab, Claudio Gratton, Solène Guenat, Catalina Gutiérrez-Chacón, Mark A Hall, Mick E Hanley, Annika Hass, Ernest Ireneusz Hennig, Martin Hermy, Juliana Hipólito, Andrea Holzschuh, Sebastian Hopfenmüller, Keng-Lou James Hung, Kristoffer Hylander, Jordi Izquierdo, Mary A Jamieson, Birgit Jauker, Steve Javorek, Shalene Jha, Björn K Klatt, David Kleijn, Alexandra-Maria Klein, Anikó Kovács-Hostyánszki, Jochen Krauss, Michael Kuhlmann, Patricia Landaverde-González, Tanya Latty, Misha Leong, Susannah B Lerman, Yunhui Liu, Ana Carolina Pereira Machado, Anson Main, Rachel Mallinger, Yael Mandelik, Bruno Ferreira Marques, Kevin Matteson, Frédéric Mccune, Ling-Zeng Meng, Jean Paul Metzger, Paula María Montoya-Pfeiffer, Carolina Morales, Lora Morandin, Jane Morrison, Sonja Mudri-Stojnić, Pakorn Nalinrachatakan, Olivia Norfolk, Mark Otieno, Mia G Park, Stacy M Philpott, Gideon Pisanty, Montserrat Plascencia, Simon G Potts, Eileen F Power, Kit Prendergast, Robyn D Quistberg, Davi De Lacerda Ramos, André Rodrigo Rech, Victoria Reynolds, Miriam H Richards, Stuart P M Roberts, Malena Sabatino, Ulrika Samnegård, Hillary Sardiñas, Karina Sánchez-Echeverría, Fernanda Teixeira Saturni, Jeroen Scheper, Amber R Sciligo, C Sheena Sidhu, Brian J Spiesman, Tuanjit Sritongchuay, Ingolf Steffan-Dewenter, Katharina Stein, Alyssa B Stewart, Jane C Stout, Hisatomo Taki, Pornpimon Tangtorwongsakul, Caragh G Threlfall, Carla Faleiro Tinoco, Teja Tscharntke, Katherine J Turo, Chatura Vaidya, Rémy Vandame, Carlos H Vergara, Blandina F Viana, Eric Vides-Borrell, Natapot Warrit, Elisabeth Webb, Catrin Westphal, Jennifer B Wickens, Neal M Williams, Nicholas S G Williams, Caleb J Wilson, Panlong Wu, Elsa Youngsteadt, Yi Zou, Lauren C Ponisio, Timothy C Bonebrake

Entomology Faculty Publications

Land use change threatens global biodiversity and compromises ecosystem functions, including pollination and food production. Reduced taxonomic α-diversity is often reported under land use change, yet the impacts could be different at larger spatial scales (i.e., γ-diversity), either due to reduced β-diversity amplifying diversity loss or increased β-diversity dampening diversity loss. Additionally, studies often focus on taxonomic diversity, while other important biodiversity components, including phylogenetic diversity, can exhibit differential responses. Here, we evaluated how agricultural and urban land use alters the taxonomic and phylogenetic α-, β-, and γ-diversity of an important pollinator taxon-bees. Using a multicontinental dataset of 3117 bee …

Chronic Heavy Alcohol Intake And Liver-Specific Lrp-1 Reduction Increase Amyloidosis In Alzheimer’S Disease Mice, Devaraj V. Chandrashekar, G. Chuli Roules, Ross A. Steinberg, Urvashi R. Panchal, Nataraj Jagadeesan, Adenike Oyegbesan, Trinh Roselyn, Joshua Yang, Sharda R. Bhagwat, Hiya Rakholia, Rutvi D. Mevawala, Moom Roosan, Derick Han, Rachita K. Sumbria

Pharmacy Faculty Articles and Research

Background

Chronic heavy alcohol drinking may be a modifiable risk factor for Alzheimer’s disease (AD), but studies in rodent AD models more closely mimic chronic moderate alcohol drinking in humans and largely focus on the brain. The role of the liver, which is significantly impacted by chronic heavy alcohol intake, in driving brain changes in alcohol-dependent AD remains unexplored. Our study using intragastric-ethanol feeding, which mimics chronic heavy alcohol intake in humans, in C57BL/6J mice showed significant AD-relevant changes in the brain and liver. Therefore, we aimed to investigate how hepatic changes using this model of chronic heavy drinking drive …

A Health Intervention Improves Cognition In Older Adults At Risk For Alzheimer’S Disease, Michelle Gray, Ray G. Urbina, Megan Jones, Anthony Campitelli, Joshua L. Gills, Sally Paulson, Jordan M. Glenn

Health, Human Performance and Recreation Faculty Publications and Presentations

Abstract Background: Alzheimer’s disease (AD) is the 7th leading cause of death and 6th most burdensome disease among US older adults. With pharmacological treatments for AD being predominantly ill-effective, alternative, non-pharmacological prevention and treatment strategies warrant exploration. Personal health coaching provides individualized strategies designed to improve physical, social, and emotional health leading to positive behavior changes that may improve cognitive ability. The purpose of the present investigation was to examine the effects of a health intervention on cognitive outcomes. Method: Adults (n = 184), 60+ years, completed a 24-month health intervention. All participants had their APOE4 status determined at baseline. …

Pathogen And Host Associations Of Soft Ticks Collected In South Texas, Sarah E. Mays Maestas, Lauren P. Maestas, Phillip E. Kaufman

School of Integrative Biological & Chemical Sciences Faculty Publications

Background: Soft ticks (Family: Argasidae) are vectors of relapsing fever Borrelia in the United States and are potential vectors of African swine fever virus, a pathogen that could have a devastating effect on the U.S. swine industry if introduced to the U.S. mainland. Much of the tick-borne disease research in the U.S. focuses on hard ticks, and less is known about the ecology of soft ticks. Some soft tick species found in the southern U.S. have a wide host range and may feed on cattle, swine, native and exotic ungulates, small mammals, reptiles, and humans. Because the feeding habit of …

Genome-Wide Association Studies In Lettuce Reveal The Interplay Of Seed Age, Color, And Germination Under High Temperatures, Sookyung Oh, Ezekiel Ahn, Ainong Shi, Beiquan Mou, Sunchung Park

Horticulture Faculty Publications and Presentations

Thermoinhibition, the suppression of seed germination by high temperatures, is an adaptive trait that ensures successful seedling establishment in natural environments. While beneficial for wild plants, thermoinhibition can adversely affect crop yields due to uneven and reduced germination rates, particularly in the face of climate change. To understand the genetic basis of thermoinhibition, we conducted a comprehensive genetic analysis of a diverse panel of Lactuca spp. accessions. Our findings revealed that L. serriola, a wild ancestor of cultivated lettuce, showed relaxed thermoinhibition response compared to cultivated lettuce, suggesting that this trait may have been positively selected during early domestication in …

Comprehensive Characterization Of The Transcriptional Landscape In Alzheimer’S Disease (Ad) Brains, Chengxuan Chen, Zhao Zhang, Yuan Liu, Wei Hong, Hande Karahan, Wenbo Li, Meichen Yu, Andrew J Saykin, Kwangsik Nho, Jungsu Kim, Leng Han

Faculty, Staff and Student Publications

Alzheimer's disease (AD) is the leading dementia among the elderly with complex origins. Despite extensive investigation into the AD-associated protein-coding genes, the involvement of noncoding RNAs (ncRNAs) and posttranscriptional modification (PTM) in AD pathogenesis remains unclear. Here, we comprehensively characterized the landscape of ncRNAs and PTM events in 1460 samples across six brain regions sourced from the Mount Sinai/JJ Peters VA Medical Center Brain Bank Study and Mayo cohorts, encompassing 33,321 long ncRNAs, 92,897 enhancer RNAs, 53,763 alternative polyadenylation events, and 900,221 A-to-I RNA editing events. We additionally identified 25,351 aberrantly expressed ncRNAs and altered PTM events associated with AD …

Compressive Pantyhose Mitigates Muscle Fatigue In Ballet-Specific Test: A Pilot Study, Gustavo R. Mota, Jeffer Eidi Sasaki, Mirelly Rangel Rocha, Pedro Augusto Bianchi Da Fonseca, Bernardo Ide, Kazushige Goto, Donizete Oliveira, Moacir Marocolo

International Journal of Exercise Science

International Journal of Exercise Science 18(2): 92-106, 2025. Compression garments, utilized in sports and exercise for performance enhancement and recovery, lack sufficient well-controlled studies to overcome any potential placebo effect. Therefore, we tested whether wearing compressive pantyhose (CP) during the Ballet-specific aerobic fitness test (BAFT) would influence performance, recovery, physiological, and perceptual indicators. Additionally, this pilot study tested the feasibility of the research procedures and informed adjustments for the main study. Nine young classical ballerinas attended two sessions on different days: a) wearing CP (pressure of 20-30 mmHg) or b) wearing a placebo pantyhose ([PLA] no compression, containing an illusory …

Fta™ Card Use For Detection Of Mycoplasma Gallisepticum In Wild Birds, Linda Purvis, Dawn E.W. Drumtra

Georgia Journal of Science

Flinders Technology Associates (FTA) cards are increasingly accepted as an accurate method for nucleic acid detection, including testing for the presence of various avian diseases. However, the accuracy of FTA cards for detection of Mycoplasma gallisepticum (MG) in wild birds has not been published. Traditional techniques for testing MG in birds include serum plate agglutanation (SPA), hemagglutination inhibition (HI), polymerase chain reaction (PCR), and enzyme linked immunosorbent assay (ELISA) all of which are time consuming and require significant financial investment into specialized equipment. We tested the efficacy of using FTA cards to detect MG in wild bird carcasses collected in …

Development And Characterization Of Sodium Alginate-Based Active Edible Films Functionalized With Olive Mill Wastewater Extract, Nassima Hadri, Mohamed Didi Ould El-Hadj, Zineb Mahcene, Fatih Bozkurt, Rusen Metin Yildirim, Youcef Rahmani, Aicha Tedjani, Muhammet Arici

Karbala International Journal of Modern Science

Phenolic compounds from olive mill wastewater (PCO) of Algerian origin were used to produce sodium alginate-based active films using the casting method. The effects of adding various concentrations of PCO (0%, 0.1%, and 0.2% w/v) were evaluated regarding the molecular, morphological, thermal, physicochemical, optical, barrier, biodegradability, antimicrobial, and antioxidant properties of the alginate films. The FTIR and SEM results elucidated the development of a coherent cross-linked structure attributed to hydrogen bonding interactions between PCO and alginate chains. Consequently, the films exhibited enhanced crystallinity and thermal stability, as revealed by DSC analysis. Moreover, PCO addition positively influenced several film properties, including …

Optimizing Biofilm Assay Reproducibility And Characterizing The 12-Hydroxystearic Acid On Escherichia Coli, Khilola Khusanova

Theses and Dissertations

Biofilm formation in Escherichia coli plays a critical role in microbial chemical communication and surface-associated persistence. This study investigates the antibiofilm activity of 12-hydroxystearic acid (12-HSA), evaluating its R and S enantiomers as well as a racemic mixture. E. coli BL21, biofilms were grown under standardized laboratory conditions and quantified using the Crystal Violet staining assay. Treatment with 12-HSA resulted in a measurable reduction in biofilm biomass, with differences observed between the individual enantiomers and the mixture. These findings suggest that 12-HSA influences early adhesion and biofilm development, supporting its potential as a small-molecule modulator of bacterial surface behavior. This …

Acute Toxicity Of Chlorimuron-Ethyl To Daphnia Magna, Jack H. Bagwell

SPARK Symposium Presentations

The acute toxicity of a sulfonylurea herbicide, chlorimuron ethyl, to Daphnia magna was determined experimentally using acute toxicity tests.

Nls-Binding Deficient Kapβ2 Reduces Neurotoxicity Via Selective Interaction With C9orf72-Als/Ftd Dipeptide Repeats, Kevin Kim, Amandeep Girdhar, Maria Elena Cicardi, V. Kankate, Miyuki Hayashi, Ruoyu Yang, Jenny Carey, Charlotte M Fare, James Shorter, Gino Cingolani, Davide Trotti, Lin Guo

Department of Biochemistry and Molecular Biology Faculty Papers

Arginine-rich dipeptide repeat proteins (R-DPRs) are highly toxic proteins found in patients with C9orf72-linked amyotrophic lateral sclerosis and frontotemporal dementia (C9-ALS/FTD). R-DPRs can cause toxicity by disrupting the natural phase behavior of RNA-binding proteins (RBPs). Mitigating this abnormal phase behavior is, therefore, crucial to reduce R-DPR-induced toxicity. Here, we use FUS as a model RBP to investigate the mechanism of R-DPR-induced aberrant RBP phase transition. We find that this phase transition can be mitigated by Kapβ2. However, as a nuclear import receptor and phase modifier for PY-NLS-containing RBPs, the function of WT Kapβ2 could lead to undesired interaction with its …

The Effects Of Active Substances Of Clinically Important Drugs On The Survival, Development, And Some Adult Traits Of Drosophila Melanogaster Meigen (Diptera: Drosophilidae), Gökçe Üstündağ, Kemal Büyükgüzel, Ender Büyükgüzel

Turkish Journal of Zoology

Drosophila melanogaster Meigen (Diptera: Drosophilidae) was used as a model organism and fed on an artificial diet with different clinically important drugs under laboratory conditions. The effects of fluconazole, acyclovir, and piperazine on the survivorship, development, adult longevity, fecundity, and hatching rate of the insect were investigated. The results showed that the highest concentration of fluconazole (1250 mg/L) significantly decreased both the rate of larvae reaching the 3rd instar and the rate of pupation from 93.00 ± 2.95% to 11.00 ± 2.59% (χ2 = 134.696; df = 1; p = 0.0001). The highest concentration of acyclovir (200 mg/L) significantly reduced …

Novel Computational And Artificial Intelligence Models In Cancer Research, Zhongming Zhao

Faculty, Staff and Student Publications

The ICIBM 2023 marked the 11th annual conference of its kind, with the ICIBM recently becoming the official conference of the International Association for Intelligent Biology and Medicine (IAIBM), showcasing cutting-edge advancements at the intersection of computation and biomedical research. A summary of the ICIBM 2023 program is provided by Li et al. [1]. As in previous years, cancer research remained a prominent focus, with numerous presentations highlighting innovative approaches to understanding and treating this complex disease. To summarize these contributions, selected works have been compiled in this Special Issue, “Novel Computational and Artificial Intelligence Models in Cancer …

A Study Of The Dormant Period Of Thaumetopoea Pityocampa (Lepidoptera: Notodontidae) In Bulgaria, Gergana Zaeмdzhikova, Md Habibur Rahman Salman

Turkish Journal of Zoology

The pine processionary moth (PPM), Thaumetopoea pityocampa (Denis et Schiffermuller), is a significant pest affecting conifer forests in the Mediterranean region. This study investigated the diapause mechanisms and survival strategies of PPM in summer and winter feeding populations in Bulgaria. The research was conducted from February to April 2021 at five pine plantation sites known for T. pityocampa activity in southwest Bulgaria. Herein, 1224 specimens were collected across different developmental stages. The sampled populations included those exhibiting typical winter feeding as well as atypical summer feeding. Morphological assessments and monitoring of the development of the individuals were conducted under controlled …

Differentiation Of Mullus Barbatus And Mullus Surmuletus (Perciformes, Mullidae) From Turkish Waters Of The Mediterranean Sea Using Otolith Shape Analyses, Semra Saygin

Turkish Journal of Zoology

Red mullet (Mullus barbatus) and surmullet (Mullus surmuletus) are valuable components of the commercial fishery industry in the Mediterranean Sea in Türkiye. To date, morphological and genetic characteristics have been used to distinguish these species. This study aimed to determine whether it was possible to distinguish between the two species using the morphometric features of their sagittal otoliths. Sagittal otoliths were subjected to elliptic Fourier analysis, wavelet analysis, and analysis of otolith shape indices for 117 specimens from the Mediterranean Sea coast of Türkiye (Mullus barbatus: 53 individuals; Mullus surmuletus: 64 individuals). Overall, canonical discriminant analysis (CDA) demonstrated strong discrimination …