Life Sciences Commons^™

Examining The Relationship Between Civic Agriculture Participation And Civic Engagement In South Texas, Allison Kaika, Dongkyu Kim, William Donner, Alexis Racelis, Owen Temby

School of Earth, Environmental, & Marine Sciences Faculty Publications

Civic agriculture is often credited with strengthening democratic life by encouraging civic and political engagement, yet this claim has scarcely been tested in socioeconomically marginalized regions. Using original survey data collected through a combination of random and purposive sampling, this study assesses that relationship in the Lower Rio Grande Valley of Texas, a majority-Hispanic agricultural region marked by high poverty and low civic participation. Phone and online surveys were administered in English and Spanish to reach both the general population and individuals involved in civic agriculture initiatives, yielding over 400 responses. We examine whether civic agriculture participation predicts greater community …

Neuroanatomical And Histological Insights Into Central Nervous System Abnormalities Of A 3-Year-Old With Progressive Encephalopathy, Lennox-Gastaut Syndrome, Micrencephaly, And Infantile Spasms, Haley Nation, Omid B. Rahimi, Rachel Morgan-Armbruster, Andrea R. Gilbert

The Journal of Integrative Physiology

Introduction: This case study presents a comprehensive neuroanatomical and histological analysis of the central nervous system from a 3-year-old donor with a rare complex neurological condition characterized by progressive encephalopathy, Lennox-Gastaut syndrome, micrencephaly, and infantile spasms. Method: This analysis was conducted using a combination of detailed gross dissection and histological examination to assess structural and neuronal abnormalities across multiple brain and spinal cord regions. External and internal analysis of the central nervous system revealed profound developmental and atrophic changes across various brain structures, including absent central sulci, abnormal gyration patterns, and severe cerebellar and cerebral atrophy. Key Findings: Key findings …

Agrivoltaic Shading Reduces Soil Greenhouse Gas Fluxes In A Semi-Arid Vineyard, Marcelo Gomes Da Silva, Rafael M. Almeida, Carine Cocco, Engil Pereira

School of Earth, Environmental, & Marine Sciences Faculty Publications

Agrivoltaic systems are expanding in semi-arid regions, raising questions about how panel driven shading alters soil greenhouse gas exchange. We used automated chambers to measure high frequency soil CO2, N2O, and CH4 fluxes in a newly established vineyard agrivoltaic system in Texas across three shading intensities (0%, 35%, 88%) that represent the light environment beneath panels as shaped by panel tilt and solar trajectory. Shading primarily cooled the soil, reducing mean soil temperature from 35.9 °C (0%) to 32.5 °C (35%) and 30.5 °C (88%), while mean soil water content shifted modestly (0.125, 0.106, and 0.130 m3 m−3, respectively). Over …

Decorin Promotes Nascent Proteoglycan Retention In Cartilage Matrix By Strengthening Collagen Ii-Aggrecan Integration, Thomas Li, Gabriela Canziani, Yuchen Liu, Neil Patel, Biao Han, Mingyue Fan, Annie Porter, Bryan Kwok, Chao Wang, Qing Li, David E. Birk, Renato V. Iozzo, Irwin M. Chaiken, X. Lucas Lu, Robert L. Mauck, Lin Han

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

Cartilage extracellular matrix (ECM), a hydrated collagen II-aggrecan composite, undergoes dynamic turnover during both normal homeostasis and disease-associated remodeling. This study elucidates a crucial role for decorin in promoting the retention and stability of nascent aggrecan within this matrix. By applying bio-orthogonal click-labeling, we demonstrate that loss of decorin accelerates the release of nascent aggrecan under both physiological and inflammatory conditions, without affecting its preferential localization to the pericellular matrix. Conversely, supplementation with exogenous decorin mitigates inflammation-induced loss of nascent aggrecan, supporting its potential as a therapeutic target. At the molecular level, decorin exhibits strong binding affinity for aggrecan, and …

Why Communicating Minimum Drawdown Elevations For Lake Powell And Lake Mead Can Mitigate Risks Of Volatile Colorado River Flow., Brittany Fager, David Rosenberg, Erik Porse

Reports

There is consensus across Reclamation’s hydrologic ensembles that volatile Colorado River flow will continue, including annual drops of 6 million acre-feet of natural flow above Lake Powell. This volatility poses risk that water managers cannot respond fast enough with the consequence that Lake Powell and Lake Mead drawdown so they no longer fulfill their Congressionally legislated purposes: deliver water, generate hydropower, protect native fish, or sustain infrastructure. In this post we suggest four reservoir operational strategies to reduce all those risks: (1) Identify Catastrophic Elevations where we lose the ability to operate reservoirs for one or more legislated purposes, (2) …

Effects Of Chronic Experimental N Deposition On Northern Hardwood Forests Fade After Cessation Of N Additions, Eileen C. Reeves, Andrew Burton, Katherine E. Higdon, Jennifer R. Eikenberry

Michigan Tech Publications

Background: Anthropogenic nitrogen (N) deposition has the potential to affect forest ecosystem carbon (C) storage and sequestration both positively and negatively. Effects on aboveground biomass increment seem to be largely positive, but the impact of elevated N inputs on soil microbial systems in forests is often negative, reducing microbial biomass and soil respiration rates. Twenty-four years of experimental N deposition at a rate of 3 g N m⁻² y⁻¹ broadly suppressed soil microorganisms across four northern hardwood forest sites. To assess responses to reductions in chronic N inputs, soil and sugar maple root samples from the study sites …

Gene × Sex Interactions On Cognition In The Philadelphia Neurodevelopmental Cohort, Josephine Mollon, Emma M. Knowles, Samuel R. Mathias, Amanda Rodrigue, Ruben C. Gur, Juan M. Peralta, Daniel J. Weiner, Elise B. Robinson, Armin Raznahan, Raquel E. Gur, John Blangero, Laura Almasy, David C. Glahn

School of Medicine Publications

Background: Small differences between females and males in cognitive abilities have been consistently reported, but the factors underlying these sex differences remain unclear. Social and cultural factors are thought to play a key role, but studies on this topic have been inconclusive. Examination of genetic factors may shed some light on the mechanisms underlying cognitive sex differences.

Methods: Using data from the Philadelphia Neurodevelopmental Cohort, a large, general population sample of individuals aged 8 to 21 years old (N = 4,694), we tested for sex differences in the genetic factors (i.e., Gene × Sex interactions) underlying cognitive ability. Participants completed …

Intramuscular Nad⁺ Therapy And Neuroenergetic Symptom Modulation: An Exploratory Retrospective Human Pilot Study, Zachary J. Dickey Do, Kirtan Patel Bs, Randy Aldret Edd, Cscs, Atc, Navneet Sharma Md, Glenn Goodwin Do

Journal for Sports Neuroscience

Abstract

Background: Nicotinamide adenine dinucleotide (NAD⁺) is a central regulator of neuronal energy metabolism, mitochondrial function, and axonal integrity. Following mild traumatic brain injury (mTBI) and repetitive subconcussive exposure, neurons undergo a neurometabolic crisis characterized by impaired oxidative phosphorylation, increased ATP demand, and depletion of intracellular NAD⁺ pools. Pre clinical models demonstrate that NAD⁺ depletion contributes to central energy dysregulation, cognitive dysfunction, and axonal and neuronal degeneration through disruption of NAD⁺-dependent pathways including SIRT1-mediated mitochondrial resilience, PARP1-driven NAD⁺ consumption, and SARM1-associated axonal breakdown. Despite growing preclinical evidence supporting NAD⁺based neuroprotection, human clinical data remains absent.

Methods: A real-world clinical pilot …

Corrigendum To " Computational Investigation Of Cavitation Inception In Centrifugal Pumps"

Mansoura Engineering Journal

Abstract is not required.

The Three Sisters And Soil Health (Lesson 1), Mara Johnson, Madhav P. Nepal, Jiyul Chang

iLEARN Teaching Resources

In this lesson, students will begin a week-long unit on soil health that is connected to the chapter The Three Sisters from the book Braiding Sweetgrass by Robin Wall Kimmerer. Students will begin the week by reading the chapter and answering discussion questions, and each subsequent day will build on this introduction with project-based learning activities. This module is designed to bridge traditional Indigenous knowledge with primary scientific inquiry, allowing students to explore soil nutrients, polycultures, and agricultural health in a way they can apply to their own lives and local food sovereignty efforts on the Rosebud Reservation.

Soil Nutrients And Composting (Lesson 3), Mara Johnson, Jiyul Chang, Madhav P. Nepal

iLEARN Teaching Resources

In this lesson, students investigate how nutrient cycling contributes to soil health and agricultural sustainability. Building upon previous lessons on the Three Sisters planting system and soil health analysis, students explore composting as a strategy for restoring nutrients in soils. Students learn the roles of carbon-rich "browns" and nitrogen-rich "greens" in decomposition and construct miniature composting systems using locally available organic materials. Through observation, data collection, and long-term monitoring, students analyze how microorganisms recycle nutrients and convert organic matter into fertile soil amendments. Students connect composting to traditional ecological knowledge, food sovereignty, environmental stewardship, and sustainable agriculture while evaluating how …

Scientific Note: Here The Whole Time: A Revised Understanding Of White Alumroot (Heuchera Alba, Saxifragaceae) In The Susquehanna River Valley., Anais Barnes, Madeline Wickers, Scott Schuette, Tanisha M. Williams, Ryan Folk, Christopher T. Martine

Faculty Journal Articles

Heuchera alba and H. pubescens (Saxifragaceae) are closely related species of alumroot endemic to the Appalachian region of eastern North America that can be difficult to distinguish morphologically. Heuchera pubescens has been understood to occupy a range from Kentucky to Pennsylvania, with the distribution of H. alba restricted to Virginia and West Virginia—plus a recently-recorded extension into Pennsylvania discovered with the help of social media. The uncovering of H. alba in Pennsylvania has challenged historical perceptions of Heuchera distributions in the state, particularly as this relates to the current concept of H. pubescens which may be in need of revision. …

Soil Health Analysis (Lesson 2), Mara Johnson, Madhav P. Nepal, Jiyul Chang

iLEARN Teaching Resources

In this lesson, students will build on the previous lesson (reading and analyzing the Three Sisters chapter from Braiding Sweetgrass) by experimenting on soil in their schoolyard. Students will collect soil samples from multiple locations around their school grounds and evaluate soil texture, structure, infiltration, color, organic matter, and pH. Students Through field observations and laboratory analysis, students examine how soil characteristics influence plant growth and ecosystem health. Students connect modern soil science with Indigenous agricultural knowledge, particularly the Three Sisters planting system described in Braiding Sweetgrass by Robin Wall Kimmerer. By exploring how healthy soil supports sustainable agriculture, …

Rape Pregnancies And Consequent Ptsd Resulting From The Overturn Of Roe V. Wade, Emma Lindenfelser, Yulia Garaeva, Nenette Nti-Agyemang, Ellen Davis, Anna Kabwa, Alexandra M Calaman

Binghamton University Undergraduate Journal

Prior to the 1973 Roe v. Wade ruling, access to safe legal abortions was limited and often restricted along racial, economic, and geographic lines. Nearly fifty years later, women’s health policy evolved again following the 2022 Dobbs v. Jackson Women’s Health Organization decision overturning Roe v. Wade. This court ruling decimated federal protections of abortion. This paper presents the research that the 2022 Dobbs judicial decision may contribute to and exacerbate rape-related PTSD on 1 out of 20 American who are unable to access a safe abortion after a rape-related pregnancy. Pregnant women living in conservative states that have outlawed …

Exploring The Effects Of Pest-Induced Hemlock Mortality On Growth In Neighboring Trees, Sidney L. Booher

McNair Culminating Research Projects

Trees provide many important products and services to humans. In particular, tree growth is critical to carbon storage, air and water quality, and helps determine demographic processes like population growth and reproductive success. Importantly, tree growth is sensitive to both abiotic (environmental) and biotic factors and is vulnerable to ecological disturbances. Understanding how tree populations respond to disturbances, like invasive pests, is therefore crucial to formulating timely and effective forest management practices.

Here, I used tree ring analysis to investigate how competition for water between neighboring trees changes following the decline of Eastern and Carolina Hemlock(ECH) trees due to the …

Exploring The Therapeutic Potential Of Kinetin In Allergic Contact Dermatitis, Hamna Muzaffar

Thesis/ Dissertation Defenses

Allergic contact dermatitis is T cell mediated inflammatory skin disorder commonly studied using contact hypersensitivity mouse model. It induces local inflammation and further evidence suggests that gut microbiome also contributes to disease progression. However, kinetin, a natural plant hormone modulates these immune processes. After TNCB successfully induces CHS, kinetin treatment resulted in significant reduction in serum IgE levels while its effect on ear swelling and histological changes were modest. Microbiome analysis revealed no major difference in alpha diversity instead beta diversity demonstrated increased microbial heterogeneity in TNCB-treated mice group. Conversely, Kinetin-treated groups exhibited a microbial profile similar to wild type …

Chromatin Insulators Homie And Nhomie Can Interact With Distant Copies Either Together Or Separately, With Distinct Outcomes For Enhancer-Promoter Interactions, Miki Fujioka, Wenfan Ke, Paul Schedl, James B. Jaynes

Department of Biochemistry and Molecular Biology Faculty Papers

Chromatin insulators, a.k.a. boundary elements, separate regions of the chromosome with distinct chromatin characteristics, including distinct histone modifications. This activity affects gene expression by allowing chromatin domains to be stably regulated and maintained. Insulators also block enhancer-promoter interactions and, somewhat paradoxically, facilitate other interactions, particularly when they stitch together distant regions of the chromosome by pairing with specific partners. Here we explore how long-range interactions facilitated by insulator pairing are affected by the presence of two potentially competing partners. Our results show that when two partners are present, they can reduce each other's effects on distant gene expression, suggesting that …

Disease-Causing Mfn2 Mutants Impair Mitochondrial Fission Dynamics By Distinct Drp1 Dysregulation, Daniel Lagos, Pamela R. De Santiago, Nicolás Pérez-Bravo, Benjamín Cartes-Saavedra, Josefa Vial-Brizzi, Diego Troncoso-Chandía, Oliver Podmanicky, Rita Horvath, Verónica Eisner

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

Mitochondria undergo fusion and fission. While DRP1 regulates fission, fusion is controlled by OPA1, MFN1, and MFN2. The balance between these processes and the crosstalk between machineries remains poorly understood. MFN2 mutations cause Charcot-Marie-Tooth disease type 2 A (CMT2A), affecting mitochondrial fusion and morphology. However, their role in fission is unclear. Using skin fibroblasts from CMT2A patients (L248H and M376V MFN2 mutations) and wild-type mouse embryonic fibroblasts expressing these variants, we studied how MFN2 mutations impact mitochondrial dynamics beyond fusion. We analyzed mitochondrial morphology and dynamics by live-cell confocal microscopy and tested fusion/fission protein levels, oxygen consumption rate (OCR), extracellular …

Discovery Of Bmi-Associated Gut Microbiome Signatures In The Awi-Gen 2 Cohort, Meriem Yagoubi

Theses and Dissertations

Obesity is increasing across sub-Saharan Africa amid rapid dietary, environmental, and urbanization transitions, yet the gut microbiome features associated with adiposity in African populations remain under-characterized. This study investigated whether species-level gut microbiome composition is associated with body mass index (BMI) in the AWI-Gen 2 cohort, and whether BMI-associated microbial signals remain detectable after accounting for the dominant geographic structure of the microbiome. Gut microbiome community structure and diversity were characterized across 1,665 participants, and differential abundance analysis was used to identify taxa associated with BMI after controlling for study site. Machine learning models were then trained to assess how …

Gamma-Glutamyl Cyclotransferase (Ggct) Supports Mitochondrial Metabolism In Pancreatic Cancer, Kailey Elizabeth Lindaur

Master's Theses

Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest cancers, with a five-year survival rate of 13%. Most tumors are resistant to chemotherapy and immunotherapy. Consequently, there is a dire need for new ways to treat PDAC patients. One major reason that PDAC is so hard to treat is because of its unique tumor microenvironment. The tumor is comprised of very dense stroma. This results in vasculature collapse and poor perfusion to the tumor, subsequently resulting in a nutrient deprived microenvironment. As a result of this, the PDAC cells will alter their metabolic profiles to one that is much more …

Shared Premotor Resources Underlie Dual-Task Interference Between Speech And Balance, Weina Lu, Sasha Lifton Lewis, Zoey Wire, Ingo Helmich

Exercise and Sport Studies: Faculty Publications

Humans frequently speak while standing, potentially engaging overlapping motor-cognitive resources. Dual-task paradigms with increased motor-cognitive demands reliably impair postural control, presumably due to competition for shared neural resources. The premotor cortex is critically involved in balance stabilization and in resolving competing motor plans and is also engaged during processing of action-related language. We therefore hypothesized that a central processing bottleneck emerges in the PMC when speaking and controlling posture simultaneously. Forty-one right-handed healthy adults (25 female, 16 male) maintained an upright stance while either verbally describing or mentally imagining navigation through a visually presented maze from an egocentric or allocentric …

Uncovering Dkk1 As A Therapeutically Relevant Target In Aggressive Er+ Breast Cancer Using A Novel Antiestrogen, Kristen Young

Dissertations

Over 70 percent of breast cancers are estrogen receptor-positive (ERα+), meaning that the hormone estrogen drives tumor growth. Although first-line targeted therapies that directly block ERα from hormone-dependent pathologies are initially effective, almost half of patients ultimately progress. These patients show high mutational rates to the ESR1 gene that encodes for ERα. A hotspot missense tyrosine to serine mutation at position 537 (Y537S) initiates hormone-independent, allele-specific transcriptional programs that increase metastasis. While next-generation ERα-targeted therapies show promise, benefits are often limited compared to standard-of-care. Understanding the mechanisms of action used by the Y537S ESR1 breast cancer cells to evade therapeutic …

Impact Of Different Light Emitting Diodes (Leds) Treatments On The Quality And Bioactive Compounds Of Cucumber (Cucumis Sativus L.) Fruit During Cold, Imad Eldin Abbas Yousif

Thesis/ Dissertation Defenses

Extending postharvest quality and maintaining the nutritional value of cucumber fruit requires specific storage conditions to postpone senescence and enhance marketability. The postharvest lightening environment is a main factor that influences quality preservation for harvested biomass. The objective of this study was to investigate the effects of different light emitting diodes (LEDs) spectra (green, red, blue, and white LEDs) alone or in combination with 1-Methylcyclopropene (1-MCP) on postharvest quality and bioactive compounds of cucumberfruit during cold storage. For 16 days at 5°C, fruits were either exposed to white, red, blue, or green LEDs or left in the dark (control). For …

Declination Of Groundwater Potential Zones Of Nashik, Maharashtra Using Geographic Information System With Analytic Hierarchy Process-Fuzzy Techniques, Madhusudhan M. Reddy, Bhogayya G. Naidu, Bharat N. Mulay, Ramanjaneyulu B, Ravi K. Kumar, Mirzi L. Betasolo, Praveen U. Goud, Snehal N. Chaudhari

Mansoura Engineering Journal

Groundwater is a critical resource for agriculture and domestic use in the semi-arid region of Nashik District, Maharashtra, where overexploitation and erratic climatic conditions have led to declining groundwater availability. This study integrates Geographic Information System (GIS) with Analytic Hierarchy Process (AHP) and Fuzzy-AHP techniques to delineate groundwater potential zones (GWPZs) and identify suitable sites for artificial recharge. A total of ten thematic layers drainage density, rainfall, geomorphology, elevation, distance from river, geology, slope, land use/land cover, topographic wetness index (TWI), and curvature were derived from SRTM DEM, Landsat-8, and IMD datasets, representing key controls on groundwater recharge, infiltration, and …

Current Status Of Anthelmintic Resistance In Meat Goats: A Comparative Efficacy Study Of Albendazole And Fenbendazole In Maha Sarakham, Thailand, Minta Pipatsakulpak, Usanisa Boonum, Kotchakorn Roongruang, Benjawan Sae-Chue, Sukanya Leethongdee, Songsak Chumpawadee, Nattaya Watwiengkam, Pongphol Pongthaisong

The Thai Journal of Veterinary Medicine

Anthelmintic resistance in gastrointestinal nematodes threatens sustainable goat production globally. While resistance is well-documented in many regions, data from Thailand remain limited. This study determined the prevalence of gastrointestinal nematodes and assessed the efficacy of albendazole and fenbendazole in meat goats in Maha Sarakham province, northeastern Thailand. A two-stage cross-sectional study was conducted on 10 meat goat farms between August 2021 and March 2022. In Stage 1, fecal samples from 150 goats were examined using simple flotation and sedimentation techniques to identify parasite morphology. In Stage 2, the McMaster technique was employed to quantify fecal egg counts (FEC). Twenty-six goats …

Diversification Of Ghost Electric Fishes (Gymnotiformes, Apteronotidae) In Tropical South America: How Traits And Environmental Factors Constrain Macroevolutionary Diversification, Jonathan Gifford Allen

Doctoral Dissertations

Neotropical electric fishes (Apteronotidae) display remarkable phenotypic and ecological diversity, offering an exceptional system for studying macroevolutionary processes in freshwater environments. Here I investigate the morphological, ecological, and historical factors shaping diversification in the clade Navajini, with a focus on craniofacial evolution, species delimitation, and biogeographic patterns. First, using high-resolution micro-CT scans, 3D geometric morphometrics, and phylogenetic comparative methods, I analyze skull shape variation across Navajini. Key traits resulting from heterocephaly exhibit strong phylogenetic signal and reflect functional differentiation among genera. Sexual dimorphism contributes significantly to cranial disparity in some lineages, while others show conserved, modular patterns likely tied to …

The Relationship Between The Environment And Pollution With Surgical Outcomes And Disparities, Wendelyn Marie Oslock

ETDs from 2020-2029

Air pollution exposure has been linked to many surgically managed diseases and adverse health events that occur in the postoperative period. Despite this, the impact of air pollution on postoperative recovery is poorly understood. This knowledge gap may be one of the underlying mechanisms for persistent disparities in surgical outcomes. Previous studies have found racial and economic disparities in air pollution exposure. These same communities have been shown to experience worse surgical outcomes. The goal of this thesis is to explore if exposure to air pollution impacts surgical outcomes and determine if disparities in socioeconomic factors impact this relationship. The …

Unh Extension Pollinator Garden Certification Application, Shyloh Favreau

UNH Cooperative Extension

When you certify your garden or landscape through The UNH Extension Pollinator Garden Certification Program, you become part of a growing community committed to creating meaningful habitat for pollinators through sustainable, science-based practices. Grounded in research, education, and shared learning, the program supports gardeners of all experience levels in contributing to the health and diversity of native pollinators. From plant selection to pollinator-friendly management practices, this application will guide you in planning, refining, and developing your garden into a safe, resilient habitat for native bees and other pollinating insects.

UNH Extension staff and Master Gardener volunteers are here to …

Growing Pains: The Loss Of Plasticity To Extreme Anoxia In Developing Embryos Of Austrofundulus Limnaeus, Patrick Ryan Clouser

Dissertations and Theses

Oxygen plays a pivotal role for most animal life on Earth, so much so that even short exposures to no oxygen, anoxia, can have severe effects on the animal's wellbeing. Conversely, aerobic recovery after anoxic insult can be just as detrimental. Some animals are the exception to this rule and demonstrate survival through anoxia and recovery. There has been a great deal of research around anoxia tolerant animals, but what remains unclear are the genetic underpinnings that determine the anoxia tolerant phenotype. RNA sequencing allows for the quantification of RNA transcripts within a sample, which can indicate if a gene …

Comparison Of Fish Biomass And Fish Carbon Content Associated With Reef Sites At The Rio Grande Valley Artificial Reef In The Gulf Of Mexico, Allison K. White, Md Saydur Rahman, Richard J. Kline

School of Earth, Environmental, & Marine Sciences Faculty Publications

As global fisheries stocks have decreased due to overfishing and climate change, artificial reefs have gained significant attention. In addition to providing or restoring habitat, artificial reefs may serve as carbon capture sinks and potential climate mitigation strategies. The Rio Grande Valley (RGV) Reef is an artificial reef located in the northwestern Gulf of Mexico off the coast of Texas. The RGV Reef area spans 1,650 acres and is comprised of hundreds of groupings of recycled and pre-formed materials ranging from low relief (1–2 ft) to high relief (8–30 ft) reef structures. This reef provides a variety of novel habitat …