Life Sciences Commons^™

A Study To Identify The Causal Rare Genetic Variants In Primary Open And Closed Angle Glaucoma, Pseudoexfoliation Syndrome, And Associated Glaucoma, Suganya K

Theses and Dissertations

BACKGROUND: Glaucoma is the second most common cause of blindness globally typically diagnosed with a triad of clinical symptoms of increased intraocular pressure (IOP) with associated optic disc, optic nerve head (ONH) changes, and visual field defects. Genetic and environmental factors are some of the strong aetiology factors for glaucoma and identification of these factors has a potential implication in the management of the disease and its outcome. There is a paradigm shift towards understanding the genetics of glaucoma, wherein the variants in the nuclear, mitochondrial genome and other regulatory regions are being identified as contributing risk factors.

METHODOLOGY AND …

Preserving Trees During And After Lawn Removal, Miles Becker, Shital Poudyal

All Current Publications

Utah is one of the driest states in the United States. Outdoor irrigation accounts for approximately 65% of its municipal and industrial water use. As the state grapples with water scarcity, lawn or turf removal to reduce irrigation has become a prominent strategy to promote more water-efficient landscaping practices. The nonfunctional turf targeted for removal often surrounds trees and shrubs. Improper or careless lawn removal can damage tree roots and lead to tree decline or death. This fact sheet provides guidance on how to protect trees while removing turf.

Creaciones En La Cocina Para Comer Juntos En Familia, Celina Wille, Lacee Jimenez, Casey Coombs, Heidi Leblanc, Lea Palmer, Jocelin Gibson

All Current Publications

Esta publicación, basada en la guía nutricional del programa SNAP-Ed, ofrece consejos prácticos y recetas culturalmente relevantes para promover una alimentación saludable y fortalecer los lazos familiares durante las comidas. Incluye conceptos básicos de planificación, un menú de muestra, guías de MiPlato e información para fomentar la participación de los niños en la cocina.

Improving Wetland Revegetation In The Intermountain West: Wetland Manager And Native Plant Vendor Insights And Challenges, Annie L. Henry, Rae Robinson, Kate Sinnott, Mark W. Brunson, Emily E. Tarsa, Adrienne Ernst, Karin M. Kettenring

All Current Publications

Diverse native vegetation supports the many ecosystem services that wetlands provide to society. In degraded wetlands, the native vegetation often needs to be reseeded or replanted as part of the restoration process. However, such wetland revegetation practices of managers are relatively undocumented and the availability of native plants for wetland restoration from vendors has been unclear. We conducted surveys of wetland managers and wetland native plant vendors in the Intermountain West in 2023 to understand their practices, challenges, and perspectives. We found that wetland managers in the Intermountain West revegetate diverse habitats for important ecosystem services despite very limited budgets …

Induced Mutagenesis In West Nile Virus Non-Structural Protein 3 With A Discussion Of The Mutation's Effects On Viral Properties, Caden Connealy

Honors Program: Senior Projects (Public)

West Nile Virus (WNV), a member of the Flaviviridae family and introduced to the Western hemisphere in 1999, presents a unique and emerging threat to human health. Infection in humans is often mild but can occasionally result in severe neurological impairment and even death. West Nile Virus non-structural protein 3 (NS3) plays an important role in the process of viral genome amplification. More specifically, the C-terminal domain of the protein folds into a helicase enzyme, which is responsible for the “unwinding” of double-stranded RNA intermediates and RNA secondary structure on the WNV genome. This is a vitally important step in …

Rheological, Interfacial, And Filtration Behavior Of Lignocellulosic Nanomaterials In Suspension And Emulsion Drilling Fluids, Meen Sung Koo

LSU Doctoral Dissertations

In recent years, the rheological aspects of suspensions/emulsions applied by cellulose nanomaterials (CNMs) have been gained considerable interests due to high gel-forming properties ascribed by hydrophilicity, crystallinity, ease functionalization, and high aspect ratio. Introducing residual lignin in CNMs (LCNMs) seemed to be capable of achieving various advantages in the application of CNMs ascribed by hydrophobicity, binding effects, and abundant aromatic groups derived from complexity of lignin. This dissertation dedicates to the characterizations of (L)CNMs, and rheological properties of (L)CNMs applied fluids (i.e., suspension and emulsion). In the suspension system, the presence of lignin in LCNMs decreased gel strength, viscosity, and …

College Of Natural Sciences 2024 Year-End Publication, College Of Natural Sciences

College of Natural Sciences Newsletters and Reports

Page 2 Dean's Message
Page 3 Department Highlights
Page 4 One Day for State
Page 5 New Students in Wecota
Page 6-8 Faculty Excellence
Page 9 SDSU Physics Students Recognized
Page 9 Prairie Doc Watch Party
Page 10-11 Student Excellence
Page 11 Connections Abroad
Page 12-13 CNS’s Research Centers
Page 14 Connections Abroad
Page 14 Dean Wolf-Hall Retired
Page 15 Outreach Program
Page 15 Events and Traditions
Page 16 Student Spotlight
Page 17 Alumni Spotlight
Page 18-19 SDSU Alum at Paris Paralympics
Page 20 Work Anniversaries & Programs

Identifying Herbicides To Manage Weeds In A Buckwheat Cover Crop And For The Control Of Volunteers, Taylor Randell-Singleton, Hannah E. Wright-Smith, Lavesta C. Hand, Jenna C. Vance, A. Stanley Culpepper

Horticulture Faculty Publications and Presentations

Buckwheat (Fagopyrum esculentum) is a fast-growing plant that quickly produces a dense groundcover. The utilization of buckwheat as a cover crop in vegetable production could be beneficial to Georgia producers, however for successful adoption, weed control in the cover crop coupled with control of buckwheat volunteers must be achievable. A preemergence (PRE) and a postemergence (POST) experiment were each conducted three times in Ty Ty, GA (2020-2021) addressing these objectives. In the PRE study, acetochlor at 0.56 lb ai acre(-1) injured buckwheat up to 16% without negatively influencing growth, suggesting potential for use in buckwheat for weed control. Flumioxazin, fomesafen, …

Barriers And Breakthroughs In The Evolution Of Aggregative Multicellularity, Israt Jahan

Arts & Sciences Graduate Student Theses and Dissertations

The evolution of multicellular organization represents a key innovation in the history of life, yet fundamental questions remain about the evolutionary mechanisms that allowed some lineages to achieve remarkable complexity, while constrained others in their elaboration. The widely accepted single-cell bottleneck model provides a compelling explanation for the success of clonal multicellularity by reducing internal conflict and facilitating developmental integration. However, this perspective does not fully account for the stability and repeated evolution of aggregative multicellularity, where cooperation emerges among previously independent cells that may not be genetic relatives. Aggregative multicellularity demonstrates that the evolution of multicellularity is not a …

Additionality Of Solar Tax Incentives Under Community Choice Aggregation In Ohio, Michael L. Smith, Carson Reeling, Michael D. Wilcox

Department of Agricultural Economics Faculty Publications

In the State of Ohio, the electric regulatory landscape permits local governments to become energy suppliers to residents and small businesses through community choice aggregation (CCA). Some CCAs provide enrollees 100% renewable electricity. Concurrently, the federal government offers an income tax credit (ITC) for the purchase of a solar array. With policy incentives, it is important to ensure they encourage behavior beyond the baseline scenario without the ITC. This is known as “additionality.” Renewable aggregation programs may crowd out the benefits of the ITC, violating additionality. This paper assesses additionality of the ITC in the context of Ohio’s CCA programs. …

Impacts Of Irrigation System, Irrigation Rate, And Cultivar On Hemp Production In The Semiarid Intermountain West, Tina Sullivan, Matt Yost, Dakota Boren, Burdette Barker, Earl Creech, Bruce Bugbee

Plants, Soils and Climate Student Research

The industrial hemp (Cannabis sativa L.) industry rapidly emerged in Utah in 2019 with nearly 480 ha of production. Production declined rapidly due to flooded floral hemp markets, but the industry is still viable in the state. Two of the most pressing questions about hemp management among growers in this region include cultivar selection and irrigation management. An outdoor hemp research trial was established in 2020 near Logan, UT (41.66 N, −111.91 W), to investigate fundamental irrigation strategies and cultivar performance. This trial (2020–2021) examined combinations of three hemp cultivars, four irrigation technologies, and three irrigation rates (100%, 75%, …

Barriers And Breakthroughs In The Evolution Of Aggregative Multicellularity, Israt Jahan

Arts & Sciences Graduate Student Theses and Dissertations

The evolution of multicellular organization represents a key innovation in the history of life, yet fundamental questions remain about the evolutionary mechanisms that allowed some lineages to achieve remarkable complexity, while constrained others in their elaboration. The widely accepted single-cell bottleneck model provides a compelling explanation for the success of clonal multicellularity by reducing internal conflict and facilitating developmental integration. However, this perspective does not fully account for the stability and repeated evolution of aggregative multicellularity, where cooperation emerges among previously independent cells that may not be genetic relatives. Aggregative multicellularity demonstrates that the evolution of multicellularity is not a …

Efficacy Of Baits And Lures For Weasel Detection, Scott M. Bergeson, Roland Kays, David S. Jachowski, Courtney D. Anderson, Chad R. Williamson, Ashley Burket, Joseph W. Butfiloski, Amanda E. Cheeseman, Stacy Cotey, Catherine C. Dennison, John D. Erb, Zach J. Farris, Michael L. Fies, Michael J. Joyce, Colleen Olfenbuttel, Blake Sasse, Lisa M. Smith, Joshua A. Tabora, Marketa Zimova

Michigan Tech Publications

Small mustelids are difficult to survey due to their low density and cryptic nature. Population status of North American weasels (Mustela erminea, Mustela nivalis, and Neogale frenata) are believed to be in decline, but there are no standardized monitoring protocols to evaluate their status. To support weasel monitoring, we compared the attractiveness of various combinations of baits and lures to weasels in sites located throughout the eastern and central USA. We baited a total of 122 clusters of 4 camera traps, across 14 states, with random combinations of 4 baits and 3 scent lures in the winters of 2022 and …

Genomics Yields Biological And Phenotypic Insights Into Bipolar Disorder, Kevin S. O’Connell, Maria Koromina, Tracey Van Der Veen, Toni Boltz, Ney Alliey Rodriguez

School of Medicine Publications

Bipolar disorder is a leading contributor to the global burden of disease¹. Despite high heritability (60–80%), the majority of the underlying genetic determinants remain unknown². We analysed data from participants of European, East Asian, African American and Latino ancestries (n = 158,036 cases with bipolar disorder, 2.8 million controls), combining clinical, community and self-reported samples. We identified 298 genome-wide significant loci in the multi-ancestry meta-analysis, a fourfold increase over previous findings³, and identified an ancestry-specific association in the East Asian cohort. Integrating results from fine-mapping and other variant-to-gene mapping approaches identified 36 credible genes …

Mesenchymal Stem Cells Loaded In Injectable Alginate Hydrogels Promote Liver Growth And Attenuate Liver Fibrosis In Cirrhotic Rats, Dominic Karl M Bolinas, Allan John R Barcena, Archana Mishra, Marvin R Bernardino, Vincent Lin, Francisco M Heralde, Gouthami Chintalapani, Natalie W Fowlkes, Steven Y Huang, Marites P Melancon

Faculty, Staff and Student Publications

Cirrhosis, a marker of severe liver diseases, limits future liver remnant (FLR) growth, preventing many cancer patients from undergoing surgery. While portal vein blockade (PVB) techniques are used to stimulate liver regeneration, 20-30% of patients still fail to achieve the required growth. Although mesenchymal stem cell (MSC) therapy improves PVB, its efficacy is limited by poor cell retention. To address this, we utilized alginate hydrogels to deliver MSCs and improve their retention. MSCs were loaded in the hydrogel and injected intraportally in cirrhotic rats. Liver volume, weights, enzyme levels, and histology were monitored. Results showed that the hydrogel maintained 89.0 …

Reducing Clinical Trial Eligibility Barriers For Patients With Mds: An Icmds Position Statement, Uma Borate, Kelly Pugh, Allyson Waller, Rina Li Welkie, Ying Huang, Jan Philipp Bewersdorf, Maximilian Stahl, Amy E Dezern, Uwe Platzbecker, Mikkael A Sekeres, Andrew H Wei, Rena J Buckstein, Gail J Roboz, Michael R Savona, Sanam Loghavi, Robert P Hasserjian, Pierre Fenaux, David A Sallman, Christopher S Hourigan, Matteo Giovanni Della Porta, Stephen Nimer, Richard F Little, Valeria Santini, Fabio Efficace, Justin Taylor, Guillermo Garcia-Manero, Olatoyosi Odenike, Tae Kon Kim, Stephanie Halene, Rami S Komrokji, Elizabeth A Griffiths, Peter L Greenberg, Mina L Xu, Zhuoer Xie, Rafael Bejar, Guillermo F Sanz, Mrinal M Patnaik, Maria Figueroa, Hetty E Carraway, Omar Abdel-Wahab, Daniel Starczynowski, Eric Padron, Jacqueline Boultwood, Steven Gore, Naval G Daver, Jane E Churpek, Ravindra Majeti, John M Bennett, Alan F List, Andrew M Brunner, Amer M Zeidan

Faculty, Staff and Student Publications

Excessively restrictive inclusion and exclusion criteria in clinical trials are one of many barriers to clinical trial enrollment for patients with myelodysplastic syndromes/neoplasms (MDSs). Many organizations are developing efforts to increase clinical trial eligibility; yet, several recent publications focused on patients with MDS suggest that many patients with this disease may be excluded from clinical trials unnecessarily. Clinical trial eligibility should reflect the phase of the study and risks of the agent being studied. Phase 3 trials should be less restrictive than early-phase trials to represent the real-world population as closely as possible. We hypothesize that many clinical trials, particularly …

The Mechanistic Target Of Rapamycin Mediates Clostridium Perfringens-Induced Chicken Necrotic Enteritis Attenuated By Secondary Bile Acid Deoxycholic Acid, Mohit Bansal, Tahrir Alenezi, Ying Fu, Janashrit Shrestha, Ayidh Almansour, Hong Wang, Anamika Gupta, Rohana Liyanage, Xiaolun Sun

Poultry Science Faculty Publications and Presentations

Clostridium perfringens is a prevalent gut bacterial pathogen in humans and animals. This study investigated the role of the mechanistic targets of rapamycin (mTOR) and deoxycholic acid (DCA) on C. perfringens intestinal infection. Chickens were sequentially infected with Eimeria maxima and received the mTOR inhibitor rapamycin and DCA. C. perfringens-induced necrotic enteritis (NE) was evaluated using body weight gain (BWG), histopathology, bile acids, pathogen colonization, cell infiltration and death, and gene expression. The significant difference of p < 0.05 was analyzed by one-way ANOVA and multiple comparisons. Notably, rapamycin strongly reduced the subclinical and clinical NE histopathologies. DCA and DCA combined with rapamycin alleviated clinical NE and BWG loss. Rapamycin, DCA, and DCA + rapamycin attenuated bile acid reduction in NE birds, and they also reduced immune cell infiltration into the intestinal lamina propria as well as immune cell migration in vitro. At molecular levels, DCA and DCA + rapamycin reduced proinflammatory IFN gamma, MMP9, IL23, and IL17 gene expression. Rapamycin, DCA, and DCA + rapamycin reduced NE-induced intestinal cell apoptosis. Together, these results suggest that mTOR signaling mediates C. perfringens-induced ileitis, and combining mTOR inhibition and DCA improves the intervention efficacy against NE ileitis and BWG loss.

Bear Lake Water Quality And Chemistry: 114 Years Of Water Management, Connely Baldwin

Spring Runoff Conference

Motivation: Fall 2024 Bear Lake Sediment-Nutrient Reduction Workshop (Bear Lake Watch) motivated deeper dive into water quality and chemistry status and trends

Development Of A Low-Cost Stem Dendrometer For Irrigation Scheduling In Fruit Trees, Anderson Luiz Dos Santos Safre, Alfonso Torres-Rua, Brent Black

Spring Runoff Conference

Motivation 

• Irrigation scheduling in water scarce regions. 
• Water stress evaluation in tart cherry orchards.
• Plant-based methods more suitable for tree crops. 
• Elevated cost of commercial dendrometers (> 1,000 USD). 

Parrotfeather (Myriophyllum Aquaticum): Biology And Management Options In Utah, Francielli S. De Oliveira

Spring Runoff Conference

Parrotfeather (Myriophyllum aquaticum)

• Invasive weed from South America.
• Heterophilic perennial dioecious plant (female in the US).
• Forms dense mats, blocks waterways, and outcompetes native species
• Spreads via rhizomes, stolons, and stem fragments.

Comparing Two Methods To Monitor Singlet Oxygen Production In Aquatic Systems: Chemical Probe Vs. Time Resolved Phosphorescence., Monika Madhiyan

Spring Runoff Conference

What’s in water?

• DOM is a naturally occurring complex mixture of organic matter
• Pollutants from domestic, industrial and agricultural effluent are introduced into surface waters

Innovative Genetic Methods For Predicting Microcystin Toxin Production In Cyanobacterial Blooms: Real-Time And Pre-Bloom Public Health Monitoring, Liyuan Hou

Spring Runoff Conference

EQL emphasizes an integrated engineering and science approach to the environmental quality of land, water, and air

Chopping Up The Riverscape: Consistent Sample Frames For Assessment And Monitoring, Jordan Gilbert

Spring Runoff Conference

Background

• Riverscapes Assessment and Monitoring Lab (RAM)
• Joe Wheaton, Wally Macfarlane, Jordan Gilbert
• Founding member of Riverscapes Consortium
• Provide tools for people working in riverscapes
• Primarily planning, implementing, and monitoring restoration projects

Growing Roots: Water Conservation, Innovative Research And Public Education, Aurora Wallis Durfee

Spring Runoff Conference

Hydroponics allows for efficient, sustainable food production, using less water and space than traditional farming methods.

Water Markets In Utah? Water Manager Perspectives On Potential Uptake, Britta L. Schumacher

Spring Runoff Conference

Irrigation organizations: intermediaries that deliver water to farms, ranches, and other users, coordinate investments in conveyance infrastructure, and manage limited water supplies.

Advancing 3d Channel Representation To Support National Scale Flood Forecasting Operations, Jose Castejon Villalobos, Anzy Lee, Noelle Patterson, Belize Lane, Colin Phillips

Spring Runoff Conference

Storms and Flooding are major annual disasters.

Paired Storms Reveal Post-Fire Flood Characteristics And Drivers, Haley Canham, Belize Lane

Spring Runoff Conference

The wildfire regime is changing in the western US.

Davis Aqueduct Reach 1 - The Design And Construction Of Large Diameter Pipelines, Shane Mcfarland

Spring Runoff Conference

Designing and building a seismically resilient 72-inch pipeline.

District Overview: Weber Basin Water Conservancy District

From Vulnerabilities And Concern To Action: How Perceived Climate Vulnerabilities And Concern For The Great Salt Lake Desiccation Shape Utahns’ Migration Decision, Mufti Nadimul Quamar Ahmed, Jennifer E. Givens

Spring Runoff Conference

In light of the current climate crisis, how do Utahns perceive their climate or disaster vulnerabilities and concern for the Great Salt Lake desiccation? Does the perception of vulnerabilities and concern for the Great Salt Lake desiccation influence their intention to migrate from Utah?

Water And Journalism Panel, Heather May, Anastasia Hufham, Ben Winslow, Sheri Quinn

Spring Runoff Conference

Respondents’ sources of information on Great Salt Lake issues