Life Sciences Commons^™

The Importance Of Well-Being For College Students, Benjamin Williamson, Dr. Mary Jan Greer, Phd, Otr

Spring 2025 OTD Capstone Symposium

Provided education on well-being, enabled independence, and improved quality of life, specifically for college students in this setting.

Advocate for Sustainable Programs:

Advocated for more programs to address the needs of college students and integrated all 8 dimensions of wellness into their current lifestyle

Support Academic Advancement:

Addressed college students' needs for overcoming occupational adversities which affects the longevity and academic success of college students

Motivate College Students:

Provided accessible and occupation-based resources that supported participating college students in independently improving their occupational roles

Advance Holistic Based Strategies:

Incorporated holistic based strategies that apply to each occupational role affecting participating …

Evaluation Of Thermotherapy On Potato Tubers To Control Tuber-Borne Nematodes, Meloidogyne Spp, Wawan Kurniawan, Supramana, Abdul Munif, Giyanto

Jurnal Kultivasi

Root knot nematodes (Meloidogyne spp.) are significant plant-parasitic nematodes frequently transmitted through potato tubers and are a major factor contributing to the decline in both crop quality and yield. This study aims to evaluate the effectiveness of thermotherapy for eliminating Meloidogyne spp. from potato tubers and its impact on sprouting viability. Thermotherapy was conducted by immersing potato tubers and second-stage juveniles (J2) of Meloidogyne spp. in water at temperatures of 50 °C, 52.5 °C, 55 °C, and 60 °C for durations ranging from 5 to 75 minutes, depending on the treatment. Parameters observed included the mortality rate of Meloidogyne spp. …

Heterologous Expression Of Maize-Derived Antimicrobial Peptide Zmes4 In Escherichia Coli For Potential Plant Pathogen Control, Suseno Amien, Dadi Nurdiana, Noor Istifadah, Noladhi Wicaksana, Haifanisa Salsabila

Jurnal Kultivasi

ZmES4 is a plant-derived antimicrobial peptide (AMP) from maize that shows promise as a biocontrol agent against plant pathogenic organisms. In the context of growing challenges in sustainable agriculture, AMPs like ZmES4 represent innovative alternatives to chemical pesticides. This study focuses on the structural characterization and heterologous expression of the ZmES4 peptide in Escherichia coli (E. coli). The gene encoding ZmES4 was obtained from the maize female gametophyte (NCBI Reference Sequence: NM_001112150.3) and cloned into the pET24d(+) expression vector using NcoI and XhoI restriction sites. Transformation into E. coli BL21 (DE3) cells enabled recombinant expression upon induction with isopropyl β-D-1-thiogalactopyranoside …

The Effect Of Soil Conditioner And Growth Booster On The Agronomic Characters And Number Of Nodules Of Black Soybean, Tien Turmuktini, I Putu Rahmat Santoso, Lia Amalia, Nunung Sondari, Elly Roosma Ria, Yenny Muliani, Endang Kantikowati, Tualar Simarmata

Jurnal Kultivasi

Soil Conditioner & Growth Booster (SCGB) is a potion that was made to be used as a soil conditioner and plant growth promoter. SCGB is made from organic matter, biological fertilizers, soil ameliorants, and microelements. This research aims to determine the best dosage of SCGB on the agronomic characters, effective nodules, and black soybean variety ‘Detam-1’ yield. This research was conducted in the experimental field of the Faculty of Agriculture, Winaya Mukti University, Sumedang, Indonesia. This experiment used a simple randomized block design (RBD) with six treatments (0, 3, 6, 9, 12, 15 kg/ha) and repeated 4 times. The observation …

The Effect Of Topping And Various Cytokinin-Based Plant Growth Regulators Applications On Immature Liberica Coffee Growth, Yudithia Maxiselly, Joshua Samuel, Cucu Suherman

Jurnal Kultivasi

The growth of Liberica coffee in the 2-year immature plant phase can be improved by applying cytokinin-based plant growth regulators (PGRs) and topping. Toppings applied to plants can inhibit apical dominance, while cytokinin PGRs such as 6-Benzylaminopurine (BAP) and coconut water can stimulate plant shoot growth. This research aims to determine the effect of topping and PGR application on the vegetative growth of Liberica coffee plants. This experiment was carried out at the Ciparanje experimental field, Universitas Padjadjaran, West Java, with an elevation of ± 750 meters above sea level from March to June 2024. The experimental design used a …

Case Study: Effect Of Stroboscopic Vision Training During A Softball Season, Doug Dendy, C Roger James, Toby Brooks, Micah Lierly, Nolan Riley, Larry Munger

Topics in Exercise Science and Kinesiology

Topics in Exercise Science and Kinesiology Volume 6: Issue 1, Article 3, 2025. This case study examined the effects of stroboscopic vision training during an entire varsity softball season for a 16-year-old female. Stroboscopic vision training uses specialized glasses with crystallized fluid that flickers, intermittently impeding vision, a technique that enhances visual performance. The stroboscopic glasses were worn two to three times a week during hitting and fielding skills. The central hypothesis was that the stroboscopic vision training would enhance softball vision performance. The central hypothesis was tested using these specific aims: 1) batting statistics for a year with no …

The Fractography Of Bone: Impact Of Flat Bone And The Story It Tells, Abigail Hoffmeister, Chase Freeman, Brandon Mendoza, Nathaniel Fitch, Annie Markarian, Jack Tran, Joshua Lau, Nicholas Tran

Seaver College Research And Scholarly Achievement Symposium

Fractography as a method for fracture analysis has been applied widely to materials that range from glass to ceramics and polymers of varying compositions. Very limited research has been done, however, to apply this knowledge of fractography and fracture patterns to bone. With the goal of telling the story of how a bone was broken, this research focuses on observing known patterns of fracture in polymers, and applying these patterns to bone. For the purposes of this research, porcine scapulae were acquired, dissected from surrounding tissue, and broken using a standardized weight drop at varying heights. The fractured bone was …

Genome Analysis Of Aeromonas Hydrophila Strain S14-452, Zarin Tasnim Raya

Undergraduate Research Conference

The Aeromonas hydrophila are gram-negative, opportunistic bacteria that can infect many groups of organisms, mainly fish and amphibians. In channel catfish, A. hydrophila causes fatal bacterial septicemia, leading to massive economic losses for catfish farmers. Therefore, an understanding of its genome will aid in identifying its virulence factors, metabolic pathways and survival mechanisms within the host. This study details the draft genome sequence of A. hydrophila strain S14-452, isolated from channel catfish exhibiting bacterial septicemia during a disease outbreak at a catfish farm.

A. hydrophila strain S14-452 was sequenced using the Illumina iSeq 100 System. Assembly was performed with SPAdes, …

Effects Of Beetroot Juice Supplementation On Power Output During Resistance Exercise In Resistance-Trained Women, Christopher B. Sottile, Sydney N. Brennan, Trevor J. Molnar, Raymond T. Gerardo, Justin M. Foster, Ryan Tran, Michael Egiazarian, Kyle S. Geppert, Abigial F. Ballhagen, Adam Pennell, Rachel Tan

Seaver College Research And Scholarly Achievement Symposium

Dietary nitrate supplementation has been reported to enhance explosive-type movements, but our understanding of the ergogenic potential of nitrate in resistance exercise and women is understudied. PURPOSE: To investigate if dietary nitrate, provided as nitrate-rich beetroot juice (BR), improved resistance exercise performance compared to nitrate-depleted beetroot juice (PL) in resistance-trained women. METHODS: Eighteen resistance-trained women were assigned in a randomized, double-blind, crossover design to consume PL (0.10 mmol nitrate) and BR (6 mmol of nitrate) 2.5 h prior to performing barbell back squats and bench press at 55% one-repetition max (1RM), 60%1RM, and 65%1RM. Power and velocity were measured via …

Discovery And Identification Of Muwow Bacteriophage From Columbus, Ms, Olivia Reese Carlisle, Jess Holden Collins, Kaliyah J. Moore, Nykeria J. Pratt

Undergraduate Research Conference

Bacteriophages are an abundant type of virus with the ability to infect and kill bacteria while using them to replicate through lytic or lysogenic processes. Bacteriophages play a key role in the regulation of bacterial populations in various environments and are being explored as potential tools in phage therapy. The aim of this study was to isolate, characterize, and manually annotate the genome of the bacteriophage MUWow collected from the campus of the Mississippi University for Women in Columbus, MS at GPS coordinates 33.493021 N, 88.419611 W. MUWow was isolated from a soil sample on Arthrobacter globiformis B-2979. Plaque assays, …

Psilocybin Impairs The Extinction Of Contextual Fear In Adult Female, But Not Male, Rats, Lillianna P. Puppel, Aleece K. Al-Olimat, Kylie M. King, Marisa J. Savini, Claire E. Miller, Colin R. Del Valle, Heather R. Sparkman, Brooke E. Bramlage, Phillip R. Zoladz

ONU Student Research Colloquium

Fear-related disorders are often treated with exposure therapy, a technique based on the concept of extinction. However, this type of therapy is ineffective for many individuals, so finding a pharmacological adjunct that augments the extinction of fear could lead to better treatment outcomes. In recent preclinical work, investigators have shown that psychedelics can accelerate the extinction of fear, potentially through their impact on neurotrophic signaling. We previously found that psilocybin exerted sex-dependent effects on the extinction of conditioned fear to an isolated cue (i.e., a tone). Specifically, psilocybin enhanced the extinction of cue fear in male rats but impaired it …

The Role Of Urbanization And Corticosterone In Auditory Sensory Processing In House Sparrows (Passer Domesticus), Brooke Fox, Ashley Lauraine, Hannah Peterson

24th Annual A. Paul and Carol C. Schaap Celebration of Undergraduate Research and Creative Activity (2025)

Urban habitat expansion will introduce new anthropogenic challenges for wildlife populations, including habitat fragmentation, novel predators, and pollution. These challenges may hinder animal communication and contribute to increased stress levels. This study will investigate the physiological consequences of stressors on the house sparrow (Passer domesticus). Specifically, we will examine how urbanization affects stress hormone (i.e., corticosterone, CORT) levels and its relationship to auditory processing. It is predicted that urbanization may impose novel stressors on animals, leading to differences in this hormone across urban and rural birds. We seek to understand if differences in CORT levels could impact animals' …

Interactions Among Nutrients Govern The Global Grassland Biomass–Precipitation Relationship, Philip A. Fay, Laureano A. Gherardi, Laura Yahdjian, Peter B. Adler, Jonathan D. Bakker, Siddharth Bharath, Elizabeth T. Borer, W. Stanley Harpole, Erika Hersch-Green, Travis E. Huxman, Andrew S. Macdougall, Anita C. Risch, Eric W. Seabloom, Sumanta Bagchi, Isabel C. Barrio, Lori Biederman, Yvonne M. Buckley, Miguel N. Bugalho, Maria C. Caldeira, Jane A. Catford, Qingqing Chen, Elsa E. Cleland, Scott L. Collins, Pedro Daleo, Chris R. Dickman, Ian Donohue, Mary Ellyn Dupre, Nico Eisenhauer, Anu Eskelinen, Nicole Hagenah, Yann Hautier, Robert W. Heckman, Ingibjörg S. Jónsdóttir, Johannes M. H. Knops, Ramesh Laungani, Jason P. Martina, Rebecca L. Mcculley, John W. Morgan, Harry Olde Venterink, Pablo L. Peri, Sally A. Power, Xavier Raynaud, Zhengwei Ren, Christiane Roscher, Melinda D. Smith, Marie Spohn, Carly J. Stevens, Michelle Tedder, Risto Virtanen, Glenda M. Wardle, George R. Wheeler

Wildland Resources Faculty Publications

Ecosystems are experiencing changing global patterns of mean annual precipitation (MAP) and enrichment with multiple nutrients that potentially colimit plant biomass production. In grasslands, mean aboveground plant biomass is closely related to MAP, but how this relationship changes after enrichment with multiple nutrients remains unclear. We hypothesized the global biomass–MAP relationship becomes steeper with an increasing number of added nutrients, with increases in steepness corresponding to the form of interaction among added nutrients and with increased mediation by changes in plant community diversity. We measured aboveground plant biomass production and species diversity in 71 grasslands on six continents representing the …

The Impact Of Consuming An Electrolyte Drink Pre Vs Post-Workout On Recovery As Measured Through Urinary Indicators In Collegiate Cross-Country Runners, Laura Taylor, Aidan Becher, Madelynn Struck, Momodou Colley

24th Annual A. Paul and Carol C. Schaap Celebration of Undergraduate Research and Creative Activity (2025)

BACKGROUND: Hydration is crucial in sports, as dehydration can decrease strength, endurance, and power. Drinking electrolytes before and after intense exercise can promote hydration. Few studies have compared the difference in consuming electrolytes pre/post-workout. The impact of consuming electrolyte drinks can be assessed by comparing pre/post-workout urinary biomarkers (UB). PURPOSE: To determine if drinking electrolytes before/after a workout improves post-workout recovery as measured by heart rate (HR) and UB in collegiate Cross Country (CC) runners. METHODS: 21 CC runners (43% men, 20±3 years) were divided into four groups. For four weeks (Sep-Oct 2024), participants consumed Liquid IV (LIV) or a …

Foraging Efficiency Of Rural And Urban House Sparrows, Passer Domesticus, Among Natural And Unnatural Obstacles, Annie Waldron, Katie Kowalyk, Mara Gutierrez

24th Annual A. Paul and Carol C. Schaap Celebration of Undergraduate Research and Creative Activity (2025)

Urbanization may lead to food displacement for many animals. Urban birds are exposed to man-made objects that can result in variable food locations, unlike rural birds who inhabit areas where food locations are typically consistent. The introduction of unnatural obstacles may affect a sparrow's ability to find and reach food sources. Scientific studies have yet to find a significant increase in problem-solving skills related to foraging in urban versus rural birds. Our research seeks to determine the foraging efficiency of rural and urban house sparrows when exposed to obstructed food sources. Novel objects near a food source may scare birds …

The Role Of Cholinergic Ventral Pallidum Cells In Effortful Motivation, Elizabeth A. Bien

Dartmouth College Ph.D Dissertations

Maladaptive reward-seeking behavior can be driven by one of several different components including excessive craving elicited by cues that predict rewards, failing to effortfully pursue rewards when it is beneficial to do so, and compulsively seeking rewards when it is no longer advantageous to do so. This thesis includes experiments focusing on these three different components of reward-seeking behavior to better understand how reward-seeking can become maladaptive. First, we wanted to examine the role that sex plays in the acquisition and compulsiveness of sign-tracking behavior in the Long Evans rat, a strain that is commonly used as the background for …

Bird Observations Across Belmont's Campus, Jeremy T. Little, Josiah C. Mustaleski

SPARK Symposium Presentations

Over the course of 10 weeks our team collected data about bird sightings on Belmont’s campus. Sessions were recorded using eBird and Merlin Bird ID to correctly identify the birds and record accurate numbers. We conducted sessions at 3 different spots on campus, each with differing types and amounts of vegetation and human presence. These sessions were 20 minutes in duration and were conducted twice a week at each location. The data gathered was used to gain a better understanding of the bird trends and demographics on campus. This data was also used for WellCore events in conjunction with the …

Local Nutrient Addition Drives Plant Diversity Losses But Not Biotic Homogenization In Global Grasslands, Qingqing Chen, Shane A. Blowes, W. Stanley Harpole, Emma Ladouceur, Elizabeth T. Borer, Andrew Macdougall, Erika Hersch-Green, Et Al.

Michigan Tech Publications

Nutrient enrichment typically causes local plant diversity declines. A common but untested expectation is that nutrient enrichment also reduces variation in nutrient conditions among localities and selects for a smaller pool of species, causing greater diversity declines at larger than local scales and thus biotic homogenization. Here we apply a framework that links changes in species richness across scales to changes in the numbers of spatially restricted and widespread species for a standardized nutrient addition experiment across 72 grasslands on six continents. Overall, we find proportionally similar species loss at local and larger scales, suggesting similar declines of spatially restricted …

Analysis Of Psychoactive Compounds In The Web-Building Behavior Of Mangora Maculata, Diane R. Castner

Undergraduate Honors Thesis Projects

The arachnid central nervous system (CNS) functions in an analogous way to the human CNS, despite spiders not having a central brain. Previous studies on spider behavior and web formation have investigated the impacts of stimulants, depressants, sedatives, and hallucinogens, but the impacts of serotonin reuptake inhibitors (SSRIs), such as fluoxetine are unknown. This study examined the impacts of caffeine, nicotine, ethanol, and fluoxetine on the web building behavior of Mangora maculata. Webs were characterized by 9 metrics: web entirety, size of web, radial angles, cell length, number of large holes, frequency of forking of spiral threads, radial angle consistency, …

Interactions Among Nutrients Govern The Global Grassland Biomass–Precipitation Relationship, Philip A. Fay, Laureano A. Gherardi, Laura Yahdjian, Peter B. Adler, Jonathan D. Bakker, Siddharth Bharath, Elizabeth T. Borer, W. Stanley Harpole, Erika Hersch-Green, George R. Wheeler

Michigan Tech Publications

Ecosystems are experiencing changing global patterns of mean annual precipitation (MAP) and enrichment with multiple nutrients that potentially colimit plant biomass production. In grasslands, mean aboveground plant biomass is closely related to MAP, but how this relationship changes after enrichment with multiple nutrients remains unclear. We hypothesized the global biomass–MAP relationship becomes steeper with an increasing number of added nutrients, with increases in steepness corresponding to the form of interaction among added nutrients and with increased mediation by changes in plant community diversity. We measured aboveground plant biomass production and species diversity in 71 grasslands on six continents representing the …

Impacts Of Riverine Heatwaves On Rates Of Ecosystem Metabolism In The United States, Spencer J. Tassone, Michelle Kelly, Olivia N. Beidler, Michael L. Pace, Amy Marcarelli

Michigan Tech Publications

Rivers produce and decompose large amounts of carbon globally due, in part, to high rates of gross primary production (GPP) and ecosystem respiration (ER), collectively known as ecosystem metabolism. Water temperature is a major driver of ecosystem metabolism, and in-stream temperatures are increasing globally, including extreme temperature events called heatwaves. This study used published estimates of daily GPP and ER from 48 stream and river locations in the United States to examine how ecosystem metabolism responds to riverine heatwaves. During low-severity heatwaves, GPP and ER increase proportionally, resulting in no net difference. However, during severe and extreme heatwaves, GPP declined …

Global And Regional Disparities In Access To Specialist Sarcoma Services, Tomas Zamora, Eduardo Botello, Thomas Jenkins, Charlotte Jeys, Minna Laitinen, Ajay Puri, Lee Jeys, Boom Consensus Meeting Participants, Santiago Abad Repiso, Hesham Abdelbary, Alejandro Abiad Mejia, Ahmed Abood, Juan C Abril Martin, Adesegun Abudu, Ayman Abu Elhamd, Marthelena Acosta, Keisuke Ae, Manish Agarwal, Vivek Ajit Singh, Toru Akiyama, Ibrahim Alshaygy, Jose I Albergo, John Alexander, Patricio A Alfaro, Bugra Alpan, Jose Amaya-Valero, Megan Anderson, Dimosthenis Andreou, Lucas Annabell, Christopher Anthony, Ahmed Aoude, William Aston, Libe Asua Mentxaka, Christine Azzopardi, Thomas Baad-Hansen, Ismail T Badr, Francisco Baixauli-Garcia, Gavin Baker, Tessa Balach, Giacomo G Baldi, Janie Barry, Georges Basile, Stefano Bastoni, Mohammad H Basuki, Henrik Bauer, Lee Bayliss, Ricardo G Becker, Angad Bedi, Joseph Benevenia, Francisco Bengoa, Peter Bergh, Marko Bergovec, Nicholas Bernthal, Odion Binitie, David Boddie, Michele Boffano, Patricia Bonilla Huertas, Anna B Borgognoni, Rajesh Botchu, Richard A Boyle, Jos Bramer, Rahat Brar, Harriet Branford-White, Demien Broekhuis, Samuel E Broida, Tymoteusz Budny, Zachary D Burke, Jorge Cabrolier, Jose A Calvo-Haro, Jorge R Calvo-Tapies, Domenico A Campanacci, Rodrigo Cardoso, Richard Carey Smith, Pedro I Carvallo, Nicolas Casales Fresenga, Jose M Casanova, Oscar Ceballos, Juan L Cebrian Parra, Laura K Certain, Sara Chancon Cartaya, Chung M Chan, Yoon Joo Cho, Peter Choong, Yang-Guk Chung, David Ciechanowicz, David Clever, Sebastian Colina, Luis Consuegra, Cory Couch, Gillian Cribb, Carlos Cuervo, Laurence A Cusick, Solomon Dadia, Tanios Dagher, Dietmar Dammerer, Mark Davies, Nerys Davies, Luis P De La Rosa Martino, Francisco J De Santos De La Fuente, Marieke De Vaal, Claudia Deckers, Javier Delgado Obando, Shaneel Deo, Niklas Deventer, Claudia Di Bella, Gregory Domson, Davide M Donati, Desiree M Dorleijn, Jacques Du Toit, Debra Dunne, Rodolfo Duran Ciarrochi, Walid Ebeid, Elina Ekman, Ahmed M El Ghoneimy, Makoto Endo, Levent Eralp, Mahmoud Etaiwi, Scott Evans, Robin Evrard, Will Eward, Alberto Farese, Peter C Ferguson, Pedro F Ferreira Cardoso, Fabrice Fiorenza, Michael Flint, Hector Flores, Joao Freitas, Bruno Fuchs, Tomohiro Fujiwara, Philipp T Funovics, Marcos Galli Serra, Zakareya Gamie, Carlos Garces-Zarzalejo, Aaron Gazendam, Carsten Gebert, Jasper G Gerbers, Craig Gerrand, Ghaith Abou-Nouar, Michelle Ghert, Kanishka M Ghosh, Max Gibbons, Luis C Gomez-Mier, Jesus Gomez-Vallejo, Anne Gomez-Mascard, Marcos R Gonzalez, Fausto Gonzalez-Lizan, Georg Gosheger, Stuart Goudie, Krista Goulding, Stavros D Goumenos, Anthony Griffin, Ashish Gulia, Sanjay Gupta, Amit Gupta, Maurice Guzman, Mohammed Haitham, Jendrik Hardes, Francisco Hardoy, Yusuf Hasan, Georg Hauer, Helard Havard, Rex Haydon, John Healey, Nerea Hernandez Gonzalez, Adriana Hernandez-Lopez, Asle Hesla, Matthew Hess, Chindanai Hongsaprabhas, Francis Hornicek, Keith Hosking, Matthew T Houdek, Eleanor Houghton, Oluwaseyi K Idowu, Joseph Ippolito, Marc Isler, Shintaro Iwata, Jake Jagiello, Neil Jenkins, Tom Jeys, Luke Johnson, Andy Johnston, Min Wook Joo, Paul C Jutte, Kadri Kaldas, Amar Kamat, Sudhir Kannan, Bilal Kapanci, Zeeshan Khan, Hiroshi Kobayashi, Yehuda Kollender, Sebastian Koob, Daniel Kotrych, Vineet Kurisunkal, Richard Kyte, Jose M Lamo De Espinosa, Alexander L Lazarides, Louis-Romee Le Nail, Pawel Legosz, Burkhard Lehner, Andreas Leithner, Maryse Lejoly, Valerae O Lewis, Peng Lin, Francisco Linares, Santiago A Lozano-Calderon, Ashish Mahendra, Ferdiansyah Mahyudin, Fermin J Mandia Mancebo, Sara Martos Torrejon, Christian Marx, Eric Mascard, Jean-Camille Mattei, Louise Mccullough, Sam Mcmahon, Manuel R Medellin Rincon, Benjamin Miller, Shinji Miwa, Gustavo Molina Uribe, Bryan Moon, Thomas Hilton, Diego J Moriel Garcesco, Carol Morris, Guy Morris, Steward Morrison, Sophie Mottard, Marcio Moura, Linde Muster, Robert Nakayama, Prashant Narhari, Ana Navas, Prakash Nayak, Johannes Neugebauer, Erik T Newman, Jyrki Nieminen, Emmy Nyqvist, Lukas Nystrom, Sarah O'Reilly-Harbidge, Gary O'Toole, Vania Oliveira, André Olivier, Mohamed Omar, Eduardo J Ortiz-Cruz, Harzem Ozger, Korhan Ozkan, Elisa Pala, Emanuela Palmerini, Grant Pang, Panayiotis Papagelopoulos, Giovanni Paraliticci, Michael C Parry, Sam Patton, David Peake, Ana Peiro Ibanez, Israel Perez Munoz, Ganapathy R Perianayagam, Michael M Petersen, Joris Ploegmakers, Robin Pollock, Gerard Powell, Juan Pretell, Jan Puetzler, Faisal Qamar, Anand Raja, Raja B Rajasekaran, Dipak Ramkumar, R L Randall, Kenneth Rankin, Kevin A Raskin, Kumaran Rassppan, Lauris Repsa, Mickael Ropars, Peter Rose, Pietro Ruggieri, Wael Sadek, German Salcedo, Aasim Saleemi, Andrea Sambri, Hartej Sar, Roberto Scanferla, Thomas Schubert, Jan Schwarze, Guido Scoccianti, Ashley Scrimshire, Tetsuya Sekita, Ahmad Shehadeh, Ahmed Shoaib, Bhim Shreemal, Felix Shumelinsky, Geoffrey Siegel, Claudio Silveri, Robert Silverwood, Friedl Sinnaeve, Jerome Sison, Andrea Slade, Maria A Smolle, Franz Snyman, Scott Sommerville, Sahil Sood, Andre Spiguel, Hugo St-Yves, Eric L Staals, Silvia Stacchiotti, Nikolas Stavropoulos, Peter Steadman, Jonathan D Stevenson, Mikaela Sullivan, Gwen Sys, Bartlomiej Szostakowski, Angela Tamburini, Yuta Taniguchi, Thomas Temple, Christoph Theil, Joachim Thorkildsen, Meagan Tibbo, Roger Tillman, Yu Toda, Kaspar Tootsi, Ferran Torner-Rubies, Frank Traub, Ioannis Trikoupis, Panagiotis Tsagkozis, Kim Tsoi, Hiroyuki Tsuchiya, Veli-Matti Vainio, Antonio Valcarcel, Juan Valencia, Annelies Van Beeck, Michiel Van De Sande, Thomas Van Den Berghe, Ingrid Van Der Geest, Lizz Van Der Heijden, Robert Van Der Wal, Kirsten Van Langevelde, Gualter Vaz, Roberto Velez Villa, Floortje Verspoor, Koenraad Verstraete, Julia Visgauss, Oleg Vyrva, Hazem Wafa, Sebastian Walter, Wan F Wan Ismail, Edward Wang, Patrick Q Wang, David Warnock, Joel Werier, Wolfram Weschenfelder, Kwok-Chuen Wong, Marjan Wouthuyzen-Bakker, Jay Wunder, Indica Wysinghe, Norio Yamamoto, Zhaoming Ye, Seung-Jae Yoon, Suraya Zainul Abidin, Pierluca Zecchetto, Liuzhe Zhang, Juan P Zumarraga, Miguel A Clara-Altamirano

Faculty, Staff and Student Publications

Aims: Cancer care guidelines have been developed in many subspecialities, usually in advanced health systems. However, there are notable global disparities in healthcare access, which can impact sarcoma care. Unfortunately, there is a lack of global data on this subject. Our aim was to describe access to sarcoma care based on a comprehensive global survey among orthopaedic oncologists, and assess for global as well as regional differences.

Methods: A 25-question survey was emailed to the attendees of the 2024 Birmingham Orthopaedic Oncology Meeting and included questions about the respondents' training and practice, access to sarcoma centres, and specific items for …

Natural Killer Cells’ Functional Impairment Drives The Immune Escape Of Pre-Malignant Clones In Early-Stage Myelodysplastic Syndromes, Juan Jose Rodriguez-Sevilla, Irene Ganan-Gomez, Bijender Kumar, Natthakan Thongon, Feiyang Ma, Kelly S Chien, Yi J Kim, Hui Yang, Sanam Loghavi, Roselyn Tan, Vera Adema, Zongrui Li, Tomoyuki Tanaka, Hidetaka Uryu, Rashmi Kanagal-Shamanna, Gheath Al-Atrash, Rafael Bejar, Pinaki Prosad Banerjee, Sophia Lynn Cha, Guillermo Montalban-Bravo, Max Dougherty, Maria Claudina Fernandez Laurita, Noelle Wheeler, Baosen Jia, Eirini P Papapetrou, Franco Izzo, Daniela E Dueñas, Salome Mcallen, Yiqian Gu, Gabriele Todisco, Francesca Ficara, Matteo Giovanni Della Porta, Abhinav Jain, Koichi Takahashi, Karen Clise-Dwyer, Stephanie Halene, Maria Teresa Sabrina Bertilaccio, Guillermo Garcia-Manero, May Daher, Simona Colla

Faculty, Staff and Student Publications

Dissecting the preneoplastic disease states' biological mechanisms that precede tumorigenesis can lead to interventions that can slow down disease progression and/or mitigate disease-related comorbidities. Myelodysplastic syndromes (MDS) cannot be cured by currently available pharmacological therapies, which fail to eradicate aberrant hematopoietic stem cells (HSCs), most of which are mutated by the time of diagnosis. Here, we sought to elucidate how MDS HSCs evade immune surveillance and expand in patients with clonal cytopenias of undetermined significance (CCUS), the pre-malignant stage of MDS. We used multi-omic single-cell approaches and functional in vitro studies to show that immune escape at disease initiation is …

Large-Scale Multi-Omics Analyses In Hispanic/Latino Populations Identify Genes For Cardiometabolic Traits, Lauren E. Petty, Hung-Hsin Chen, Elizabeth G. Frankel, Wanying Zhu, Carolina G. Downie, Mariaelisa Graff, Phillip Lin, Priya Sharma, Ravi Duggirala, John Blangero

Human Genetics Publications

Here, we present a multi-omics study of type 2 diabetes and quantitative blood lipid and lipoprotein traits conducted to date in Hispanic/Latino populations (nmax = 63,184). We conduct a meta-analysis of 16 type 2 diabetes and 19 lipid trait GWAS, identifying 20 genome-wide significant loci for type 2 diabetes, including one novel locus and novel signals at two known loci, based on fine-mapping. We also identify sixty-one genome-wide significant loci across the lipid/lipoprotein traits, including nine novel loci, and novel signals at 19 known loci through fine-mapping. Next, we analyze genetically regulated expression, perform Mendelian randomization, and analyze association with …

Characterization Of Long-Noncoding Rnas In Prostate And Pancreatic Cancer Through Single Cell Transcriptomics, Debanjan Saha

Arts & Sciences Graduate Student Theses and Dissertations

Metastatic castration resistant prostate cancer (mCRPC) is a subtype of prostate cancer that develops after metastasis and resistance to hormone therapy, thereby carrying a poor prognosis. Likewise, pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal malignancies due to its propensity to present at advanced, unresectable stages in patients. Recent genomic studies have identified molecular features of mCRPC and PDAC, such as the existence of mutations in key driver genes, the extensive transcriptomic intra-tumoral heterogeneity, the role of regulatory elements in dictating driver gene expression, mechanisms of treatment resistance, and the interactions with the immunosuppressive and stromal tumor- microenvironment …

A Cluster Randomized Trial Of Xylitol Chewing Gum For Prevention Of Preterm Birth: The Ppax Trial, Gregory C Valentine, Kathleen M Antony, Haleh Sangi-Haghpeykar, Alexis C Wood, Rose Chirwa, Saukani Petro, Mary Dumba, Deborah Nanthuru, Cynthia Shope, Jesse Mlotha-Namarika, Jeffrey Wilkinson, Joshua Aagaard, Ellen J Aagaard, Maxim D Seferovic, Judy Levison, Peter Kazembe, Kjersti M Aagaard

Children’s Nutrition Research Center Staff Publications

Background: Maternal periodontal disease is associated with preterm and low-birthweight deliveries, but randomized trials of likely efficacious treatments (e.g., dental scaling and root planing) during pregnancy have not reduced these adverse outcomes. As an alternative, we hypothesized that periconception initiation of xylitol chewing gum would reduce the occurrence of preterm or low-birthweight deliveries among a historical high-prevalence population in Malawi.

Methods: We conducted an open-label, parallel-enrollment, matched-pair, cluster-randomized, controlled clinical trial across eight health centers (sites) in and around Lilongwe, Malawi. Sites were paired by anticipated delivery volume and randomized to prenatal and oral health education alone (active control) or …

Nutrition Education Intervention For Patients Living With Hiv Attending An Outpatient Clinic In Dubai, Uae, Souheir Mahmoud Alia

Thesis/ Dissertation Defenses

Nutrition is crucial to HIV/AIDS management. HIV affects the immune system, making infections and illnesses harder to resist. Despite the importance of nutrition for people living with HIV (PLHIV), there have been no studies of nutritional interventions for PLHIV in the MENA region. Aim: The objective of this study is to assess the baseline status of PLHIV and the impact of a lifestyle intervention on various aspects of their health and lifestyle status, including nutritional knowledge, attitude and practices (KAP), and intake of immune-boosting food/nutrients. Methods: Sixty-three patients attending an outpatient clinic in Dubai were randomly assigned to an intervention …

Study Of Falaj Paths And Their Unknown Extension In Al Ain City Using Geophysical Methods, Saud Mohammed Alsenaani

Thesis/ Dissertation Defenses

Historically, the city of Al Ain has relied on its Falaj systems for freshwater, which is vital for drinking and irrigating its oases. These historic water resources have been essential for supporting life in the region for centuries, providing the foundation for communities and farming. The remarkable rainfall in 2024 uncovered several hidden ancient Falaj systems, and newly enlarged versions of previously recorded ones, highlighting the importance of ongoing research for their preservation. The research project aims to examine the current Falaj systems in Al Ain, particularly Falaj Mazyad, by applying geophysical methods to identify uncharted extensions. The aim of …

Study Of The Extension Of Cavities In Jebel Hafeet By Implementing Geophysical Methods, Mai Rashed Alkaabi

Thesis/ Dissertation Defenses

Subsurface cavities pose challenges to the buildings and their stability, leading to ground instability and subsidence. In Al Ain City, UAE, particularly in Jebel Hafeet, cavities within carbonate formations and sedimentary rocks present risks to infrastructure and urban development. This study employs Electrical Resistivity Tomography (ERT) and Gravity Surveys to detect, locate, and determine the depth of these cavities, enhancing geological understanding and geohazard assessment. The ERT survey, using a pole-dipole array, was conducted along eight lines to identify subsurface anomalies. It revealed high-resistivity anomalies (> 45 Ω·m), indicative of air-filled cavities, and low-resistivity zones (< 6 Ω·m), corresponding to water-saturated or clay-rich deposits. The ERT survey detected resistivity variations, highlighting anomalies ranging from 45 to 120 Ω·m at depths between 1 m and 17 m. The gravity survey, conducted at 28 stations, detected low-density anomalies, whichaligned with high-resistivity ERT zones, confirming subsurface cavities at depths between -20 m and -200 m (a.s.l.). Five 3D gravity inversion models visualized density variations, revealing cavities at different depths from 50 m to 250 m. The integration of ERT and gravity methods significantly improved cavity detection accuracy, demonstrating a strong correlation between low-density gravity anomalies and high-resistivity features. This study recommends increasing gravity station density and avoiding heavy infrastructure in cavity-prone areas. The findings contribute to the geological understanding of Jebel Hafeet, providing insights for sustainable urban planning, risk mitigation, and infrastructure safety in Al Ain City.

Determination Of The Effects Of Biogenic Metal Nanoparticles Concentrations On Soil Properties, Vicia Faba Growth And The Toxicity On Black Aphid, Ayoub Sabir Karim, Halala Rahman Qadr, Sakar Abdulqadr Saeed, Nashmeel Saeed Khudhur

Karbala International Journal of Modern Science

The development of nanomaterials could support more extensive agricultural uses, including nano-pesticides. Current study was conducted to observe the effects of different concentrations (25, 50, 75, 100, 150 and 200 ppm) of biosynthesized zinc oxide nanoparticles (ZnO NPs) and aluminum oxide nanoparticles (Al₂O₃ NPs) on soil, faba bean and toxicity on black aphid (Aphis fabae). The synthesized ZnO NPs from Musa paradisiaca L. characterized by ultraviolet (UV)-visible spectroscopy, Fourier Transform Infrared Spectroscopy, X-ray diffraction and Transmission electron microscopy. Al₂O₃ NPs was prepared by calcination of Iraqi kaolin via evaporation process. Highest pH …