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Full-Text Articles in Life Sciences

Improving Nutrition Outcomes Through Enhanced Allocative Efficiency Of Investments In 24 High Risk Counties In Kenya: An Optima Nutrition Modelling Study, Morris Ogero, Nick Scott, Veronica Kirogo, Anthony Ngugi May 2025

Improving Nutrition Outcomes Through Enhanced Allocative Efficiency Of Investments In 24 High Risk Counties In Kenya: An Optima Nutrition Modelling Study, Morris Ogero, Nick Scott, Veronica Kirogo, Anthony Ngugi

Population Health, East Africa

Introduction ;Undernutrition remains a significant global challenge, severely impacting children’s development and growth. To address this, the Sustainable Development Goals target a substantial reduction in stunting and wasting by 2025. Achieving these goals requires scaling up evidence-based nutritional interventions; however, limited budgets pose challenges in funding all necessary programs. To assist policymakers in making informed decisions, the World Bank developed the Optima Nutrition Modelling tool, which optimizes the allocation of nutrition investments. Kenya, with its high prevalence of stunting, was the focus of this study. Using the Optima Nutrition model, we aimed to (1) assess the impact of scaling up …

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Parasitic Effects Of Amoebidium Appalachense On Daphnia Magna Heart Rate, Hopping Frequency, And Metabolic Rate, Vanessa Wise May 2025

Parasitic Effects Of Amoebidium Appalachense On Daphnia Magna Heart Rate, Hopping Frequency, And Metabolic Rate, Vanessa Wise

Honors Program: Senior Projects (Public)

Daphnia magna are a crustacean that inhabits multiple different types of freshwater ecosystems and thus is plays a part in many different types of interspecies interactions, one of which is parasitism. Amoebidium appalachense is a Mesomycetozoean parasite of aquatic arthropods that colonizes the antenna of D. magna. Previous research has shown that A. appalachense infection will reduce the fecundity and increase mortality rate of D. magna but how it causes these effects is unknown. To determine if A. appalachense causes these effects on D. magna by either stealing nutrients inside the D. magna like a tick or by compromising …

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Evolution And Strengths Of School Lunch Programs In The United States And Japan, Sarah Ritterling May 2025

Evolution And Strengths Of School Lunch Programs In The United States And Japan, Sarah Ritterling

Honors Program: Senior Projects (Public)

School lunches around the world perform a vital role in children’s nutritional needs and overall health. These nutritional programs provide a chance for children to learn how to create a balanced meal and about the production and serving of food. However, many countries, including the United States and Japan, have taken different approaches to meet these goals, influenced by the needs of children and communities over time. The United States provides support, funding, and nutritional standards through the National School Lunch Program. Japan promotes the Basic Act of Shokuiku (food and nutrition education) within society and outlines goals for schools …

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Passive Dna Transfer To Fidget Blasters Stored In Cars, Rachel Chan May 2025

Passive Dna Transfer To Fidget Blasters Stored In Cars, Rachel Chan

Student Theses

This study evaluated the amount of detectable DNA accumulated on clean plastic fidget blasters, used to simulate firearms, over a seven-day storage period inside a vehicle. Twelve volunteers were asked to place one fidget blaster each in the glove box and underneath the driver’s seat from behind. After the seven-day period, the volunteers returned the fidget blasters, donated a reference sample, and filled out a questionnaire. The grip, slide, and trigger were swabbed for DNA and extracted. The extracts were quantified to determine the concentration of human DNA, and if the samples met the PCR threshold to be genotyped. The …

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Investigating The Effects Of Hepatocyte Growth Factor On Primary Myoblast Proliferation, Grace Heller May 2025

Investigating The Effects Of Hepatocyte Growth Factor On Primary Myoblast Proliferation, Grace Heller

Biomedical Engineering

Peripheral artery occlusive disease (PAOD) is a progressive vascular condition that affects over 200 million people worldwide and approximately 8 million in the United States. It is characterized by atherosclerotic narrowing of peripheral arteries, leading to reduced blood flow, ischemia, and, in severe cases, tissue loss and limb amputation. Although surgical revascularization is the gold standard, many patients—particularly those with comorbidities like diabetes— continue to experience poor outcomes, emphasizing the need for alternative therapies. One promising strategy is to enhance collateral arteriogenesis, the remodeling and enlargement of collateral arterioles that naturally bypass occluded vessels. Satellite cells (SCs), which give rise …

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Wired For Degradation: How Post-Translational Control Of Inducible Camp Early Repressor Protein Influences Melanoma Fate, Melissa Rose Spigelman May 2025

Wired For Degradation: How Post-Translational Control Of Inducible Camp Early Repressor Protein Influences Melanoma Fate, Melissa Rose Spigelman

Theses, Dissertations and Culminating Projects

Melanoma is a highly aggressive form of skin cancer frequently driven by mutations in the BRAF gene, particularly the BRAFⱽ⁶⁰⁰ᴱ variant, which leads to sustained activation of the MAPK signaling cascade. Recent studies implicate the cyclic AMP (cAMP) signaling axis in melanoma progression and therapeutic resistance, highlighting the role of the Inducible cAMP Early Repressor (ICER), a transcriptional antagonist of CREB and CREM. ICER is downregulated during melanomagenesis and subject to post-translational regulation via phosphorylation and ubiquitin-mediated degradation. To investigate ICER’s functional relevance in vivo, e utilized a zebrafish melanoma model harboring brafⱽ⁶⁰⁰ᴱ, tp53−/−, and mitf−/−mutations, in which mitf expression …

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Understanding Pre-Harvest Hedging Behavior And Basis Forecasting: The Role Of Information In Grain Marketing, Iyore Eronmwon May 2025

Understanding Pre-Harvest Hedging Behavior And Basis Forecasting: The Role Of Information In Grain Marketing, Iyore Eronmwon

Dissertations and Doctoral Documents, University of Nebraska-Lincoln, 2023–

This dissertation examines decision-making under risk in grain marketing, focusing on how information influences behavior, attitudes toward accessible information, and methods for forecasting commodity basis. Through three essays, it explores the impact of information on hedging decisions, the determinants of information-seeking behavior, the extent to which students can serve as proxies for farmers in risk experiments, and the effectiveness of different forecasting approaches for commodity basis.

The first essay examines the impact of information on pre-harvest grain marketing hedging decisions and grain marketing information-seeking behavior. Specifically, it evaluates two types of information hypothesized to influence decision-making: expected cost of production …

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Considerations And Techniques For Producing Urban Tree Canopy Maps Using Freely Available And Accessible Methods, Hugh Reed Ellerman May 2025

Considerations And Techniques For Producing Urban Tree Canopy Maps Using Freely Available And Accessible Methods, Hugh Reed Ellerman

Dissertations and Doctoral Documents, University of Nebraska-Lincoln, 2023–

Urban forests are valued as green infrastructure for the variety of benefits they provide across ecological, social, public health, and economic domains. To understand the distribution of trees, maps are required. Many methods of mapping tree cover use expensive and data-intensive datasets such as hyperspectral and LiDAR imagery, making these methods inaccessible to municipal forest managers. Variations in the modelling approaches of existing, freely available methods are not addressed in sufficient enough detail to understand the trade-offs implicit in these variations. Further, characteristics of urban tree canopy mapping (high spatial resolution imagery, heterogeneous urban environments, the importance of the tree …

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Gonadotropin-Releasing Hormone Ii And Its Receptor: Novel Regulators Of Semen Quality And Follicular Function In Swine, Caitlin Elizabeth Ross May 2025

Gonadotropin-Releasing Hormone Ii And Its Receptor: Novel Regulators Of Semen Quality And Follicular Function In Swine, Caitlin Elizabeth Ross

Dissertations and Doctoral Documents, University of Nebraska-Lincoln, 2023–

Pigs are the only mammalian livestock species encoding functional proteins for the second form of gonadotropin-releasing hormone (GnRH-II) and its receptor (GnRHR-II). In the first study, GnRHR-II localized to developing germ cells and the connecting piece of ejaculated spermatozoa. Concurrently, GnRH-II was most abundantly produced in the testis compared with other reproductive tract organs and was present within seminal plasma. Moreover, treatment of extended semen with GnRHR-II analogues altered sperm motility, morphology, and kinematics. For remaining studies, we utilized a swine line with ubiquitous knockdown of GnRHR-II (GnRHR-II KD) developed in our laboratory. The second study demonstrated that circulating GnRH-II …

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A Stakeholder-Informed Conceptual Framework For Evaluating Genomics In Precision Oncology, Julie A. Wiedower May 2025

A Stakeholder-Informed Conceptual Framework For Evaluating Genomics In Precision Oncology, Julie A. Wiedower

All Dissertations

This dissertation explores the value of genomic testing in precision oncology with an emphasis on how US payers conceptualize and prioritize elements of value. This research aims to address gaps in understanding payer perspectives and proposes a stakeholder-informed framework for evaluating genomic testing in oncology. To achieve this aim, the presented research investigates payer perspectives, value-based cancer care priorities, and the conceptual understanding of the value of a genetic diagnosis to establish a framework for value with the payer audience in mind. Chapter 1 outlines relevant background information relating to the genomic revolution and challenges in translating genomic testing technologies …

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The Genomic Landscape And Prognostic Impact Of Kras, Stk11, And Smarca4 Mutations And Co-Mutations On Survival Outcomes In Non-Small Cell Lung Cancer, Peter Manolakos May 2025

The Genomic Landscape And Prognostic Impact Of Kras, Stk11, And Smarca4 Mutations And Co-Mutations On Survival Outcomes In Non-Small Cell Lung Cancer, Peter Manolakos

All Dissertations

Non-small lung cancer (NSCLC) accounts for 85% of lung cancer cases, and Kirsten rat sarcoma viral oncogene homolog (KRAS), Serine/Threonine Kinase 11 (STK11), and SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin, subfamily A, member 4 (SMARCA4) mutations and co-mutations have been increasingly recognized for their potential prognostic significance. However, clear knowledge gaps remain regarding which treatments should be selected for patients who present clinically with KRAS/STK11 or KRAS/SMARCA4 co-mutations, as outlined in Chapter 1. Despite significant clinical development advancements in immunotherapy and targeted therapy, a deeper understanding of the influence of these genomic …

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Stromal Cells In The Small Intestine: Physiology, Localization, Function, And Alterations Induced By Chronic Arsenic Exposure, Scott Ventrello May 2025

Stromal Cells In The Small Intestine: Physiology, Localization, Function, And Alterations Induced By Chronic Arsenic Exposure, Scott Ventrello

All Dissertations

Arsenic is a prevalent toxicant found to affect around 94 to 240 million individuals in over fifty countries who are exposed to levels above the EPA and WHO standard of 10 ppb. As one of WHO’s top ten chemicals of public health concern, it is linked to several chronic diseases including diabetes, obesity, cancers, and inflammatory bowel diseases. Arsenic increases inflammation and disrupts the intestinal barrier in the small intestine and colon. Further, previous studies found that arsenic decreased secretory cell lineage and stromal cell gene expression markers in the small intestine. Thus, our goal was to investigate arsenic’s effect …

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Exploring Community Change Of North American Stream Fish Communities Due To Species Introductions, William K. Annis Jr May 2025

Exploring Community Change Of North American Stream Fish Communities Due To Species Introductions, William K. Annis Jr

All Dissertations

The introduction of nonnative species has facilitated global changes in beta diversity, and these changes have been coined biotic homogenization (loss in beta diversity) and differentiation (gain in beta diversity). Homogenization represents a key conservation threat. Therefore it is imperative to understand the processes that allow nonnative species to establish and how these species contribute to beta diversity change. In this dissertation, I assess three key challenges exist in our ability to address these goals. One challenge is that we have inconsistent support among hypotheses of invasion drivers due to context dependency. Context dependency can arise due to differences in …

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Identification And Characterization Of Intermediate Phenotypes To Decipher Genetic Architecture Of Stalk Lodging Resistance In Maize (Zea Mays L.), Bharath Kunduru May 2025

Identification And Characterization Of Intermediate Phenotypes To Decipher Genetic Architecture Of Stalk Lodging Resistance In Maize (Zea Mays L.), Bharath Kunduru

All Dissertations

Maize is a key contributor to global food security and incurs severe yield losses due to stalk lodging, the permanent displacement of plants from an upright growth habit due to mechanical damage to the stem (stalk). Stalk lodging resistance, an indicator of the stalk ability to resist lodging, is a complex trait and determined by several structural, geometric, and material properties of stalks, collectively referred to as intermediate phenotypes, whose identity and genetic framework are poorly understood. Therefore, progress in resolving the genetic architecture of stalk lodging resistance was impeded by a lack of standardized phenotyping methodologies and a poor …

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Spatial Variaiton In Host-Associated Microbiota, Daniel Malagon May 2025

Spatial Variaiton In Host-Associated Microbiota, Daniel Malagon

All Dissertations

Many organisms rely upon the internal and/or external microbial communities they harbor. Microbial communities which depend upon other organisms for survival are known as host-associated (HA) microbial communities. HA microbial communities differ in diversity and composition from surrounding environmental microbiota and are generally less diverse than surrounding soil microbiomes. Although distinct bacterial profiles exist between host and environment, microbial scale dispersal often links the two. For this reason, host and environmental microbial communities can be correlated (e.g., dominant taxa in HA microbiota are dominant in the host microenvironment or vice versa). Eukaryotic hosts act as islands for HA microbiota. Unlike …

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Understanding The Genetic And Metabolic Underpinnings Of Complex Traits In C4 Grasses, Manwinder Singh Brar May 2025

Understanding The Genetic And Metabolic Underpinnings Of Complex Traits In C4 Grasses, Manwinder Singh Brar

All Dissertations

Maize (Zea mays L.) and sorghum (Sorghum bicolor (L.) Moench) are two important cereal crops cultivated worldwide for food, animal feed, and industrial products. Productivity of these crops is significantly impacted by various biotic and abiotic stresses, such as diseases, insect pests, drought, salinity, and heat. Among factors influencing crop performance under stress, the regulation of leaf longevity plays a critical role in determining yield. Leaf senescence is a highly regulated process essential for nutrient remobilization through the degradation of cellular components in aging leaves, but premature or accelerated senescence reduces photosynthetic efficiency and yield. Staygreen, a phenotype …

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Amyloid Aggregation And Mitigation, Zhenzhen Zhang May 2025

Amyloid Aggregation And Mitigation, Zhenzhen Zhang

All Dissertations

The buildup of protein in tissues and organs plays a major role in unfunctional several serious diseases, including Alzheimer’s disease, Parkinson’s disease, and Type 2 diabetes, each tied to specific proteins that form harmful amyloid deposits. Amyloid aggregation typically follows a sigmoidal kinetic curve, beginning with a slow lag phase, followed by rapid fibril growth, and eventually reaching a plateau where mature, stable fibrils are formed. However, the early stage of aggregation remains particularly difficult to capture experimentally due to the highly dynamic nature and low abundance of small oligomeric species. In this dissertation, we employed discrete molecular dynamics (DMD) …

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The Impacts Of Management Practices On Industrial Hemp Chemistry, Physiology, And Microbiome Ecology., Allison Marie Rietman May 2025

The Impacts Of Management Practices On Industrial Hemp Chemistry, Physiology, And Microbiome Ecology., Allison Marie Rietman

Electronic Theses and Dissertations

Agroecology incorporates ecology and agronomy to inform crop management. Industrial hemp (Cannabis sativa L.) is a prime system to investigate agroecological questions because it has only recently been authorized for commercial cultivation and its sensitivity to biotic and abiotic stressors is unresolved. Here, I investigate how some conventional management choices, including the application of fungicide, plastic mulch, and irrigation, impact the physiology, chemistry, and microbial ecology of industrial hemp. Overall, I found that industrial hemp can be both resilient and resistant to these stressors, an important development for the industry. In Chapter II, I tested the impacts of fungicide application …

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What Happens To Soil And Native Plant Life After Removal Of Lonicera Maackii In An Urban Temperate Forest?, Sheryl A. Gipson Hammond May 2025

What Happens To Soil And Native Plant Life After Removal Of Lonicera Maackii In An Urban Temperate Forest?, Sheryl A. Gipson Hammond

Electronic Theses and Dissertations

In evaluating the potential effects of nitrogen cycles and pH on plant diversity and richness after the removal of Lonicera maackii in a temperate urban forest in Louisville, Kentucky, data was collected including nitrogen, pH, canopy, stem count, and plant surveys. The cutting and treatment with chemicals to remove L. maackii were successful one year after the treatments, but legacy effects ensued about five years thereafter. Native diversity waned as monoculture proliferated in some areas, including second invasions of the invasive. It was expected that nitrogen and pH would explain the success (or lack thereof) of native plant response as …

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The Effects Of Geographic Isolation And Anthropogenic Activity On The Social Behavior Of Caribbean Green Monkeys., Rose Amrhein May 2025

The Effects Of Geographic Isolation And Anthropogenic Activity On The Social Behavior Of Caribbean Green Monkeys., Rose Amrhein

Electronic Theses and Dissertations

Green monkeys (Chlorocebus sabaeaus) arrived to the Caribbean with the Trans-Atlantic slave trade. Since then, they have experienced unique environments to those of their native ranges in West Africa. Additionally, recent taxonomic changes within the genus make previous knowledge about the species hard to determine to be accurate. In this dissertation, I both assess some of the effects the island environment may have had on monkey behavior as well as build on the understanding of their vocal communication across three islands: Barbados, St. Kitts, and St. Martin. In chapter one, I investigate how human activity in Barbados affects …

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Analyzing The Association Of Competitive Food Policy On Competitive Food Content In U.S. Schools., Mary E. Curnutte May 2025

Analyzing The Association Of Competitive Food Policy On Competitive Food Content In U.S. Schools., Mary E. Curnutte

Electronic Theses and Dissertations

OBJECTIVES: School food can have a profound effect on the population’s health. Thirty million children receive food at school and consume half their daily calorie intake at school. Competitive foods are foods sold outside of school breakfast and lunch, such as those sold in vending machines. A new ruling for Smart Snacks Standards, a set of competitive food guidelines, started in the school year 2014-2015. It is known that competitive foods undermine school lunch participation, and a decrease in school lunch consumption is associated with poorer student health. Additionally, an increase in competitive foods tends to be of nutrient-poor …

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Sars-Cov-2 Modulates Pla2g2d/Pgd2 Signaling To Manipulate Host Immune Response To Increase Disease Severity., Dante L. Hamiel May 2025

Sars-Cov-2 Modulates Pla2g2d/Pgd2 Signaling To Manipulate Host Immune Response To Increase Disease Severity., Dante L. Hamiel

Electronic Theses and Dissertations

Background: Previous studies suggested that SARS-CoV-2 infection could cause diverse immune and metabolic dysregulations, although the underlying mechanisms remain poorly understood. In addition, viruses may escape the immune response by modulating cellular metabolism, mitochondria, and protein functions indicating that immune or metabolic components may represent novel targets for anti-viral strategies. However, whether immune and metabolic disorders interact or affect each other waits to be determined. On the other hand, previous investigations identified the critical roles of a cell membrane-bound phospholipase PLA2G2D and its downstream products PGD2 in regulating the metabolism and inflammation in respiratory system. More importantly, …

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Integration Of Multi-Omics Datasets Evaluating Structural And Functional Features Of The Gut Microbiome In People With Hiv (Pwh)., Aakarsha Vijayakumar Rao May 2025

Integration Of Multi-Omics Datasets Evaluating Structural And Functional Features Of The Gut Microbiome In People With Hiv (Pwh)., Aakarsha Vijayakumar Rao

Electronic Theses and Dissertations

Gut dysbiosis characterized by reduced abundance of beneficial butyrate-producing bacteria has been independently linked to HIV-1 infection and heavy alcohol drinking. Further, gut dysbiosis results in loss of gut barrier integrity, microbial translocation and host-specific systemic inflammation. Therefore, to evaluate the functional consequences of structural changes in the gut microbiome, integrated data analysis is imperative. In this dissertation, we perform integrated analyses using data from multi-omics platforms to examine the structural and functional features of the gut microbiome of PWH. Gut microbiome composition was evaluated by sequencing V4 region of 16S rDNA, concentrations of metabolites and host-specific immune markers were …

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Development And Functional Characterization Of Carbon Nanodot-Peptide Conjugates For The Treatment Of Bone Disease, Abigail Ali May 2025

Development And Functional Characterization Of Carbon Nanodot-Peptide Conjugates For The Treatment Of Bone Disease, Abigail Ali

Honors Theses

Carbon nanodots (CDs) synthesized from carbon nanopowder under acid oxidative conditions have unique bone-bind properties that could be exploited for theranostic purposes. In the zebrafish vertebrate model system, CDs bind to bone with high affinity and specificity, they don’t appear to bind to other tissues and they do not affect the bone physiology or animal viability. Thus, carbon-derived CDs could be developed for the delivery of pharmacological agents to bones to treat diseases such as osteoporosis. Biologicals such as peptides, proteins and antibodies are a new and exciting class of pharmacological agents that have been successfully used in treating complex …

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Synthetic Modification Of Agrobacterium To Inhibit Plant Pathogenesis, Rosemala Agarwala May 2025

Synthetic Modification Of Agrobacterium To Inhibit Plant Pathogenesis, Rosemala Agarwala

Honors Theses

Crown Gall disease caused by Agrobacterium is a leading cause of plant damage and current solutions used to prevent the disease are not as effective. This research aims to use a synthetic biology approach to design a plasmid that upregulates Curdlan, a molecule that activates plant defenses, when the bacteria senses a wounded plant. Thus this research uses a synthetic biology approach to develop a biocontrol agent for Crown Gall disease. This research also looks at the transferability of the sugar phenol sensing mechanism in Agrobacterium, which is needed for plant pathogenesis.

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A Cross-Taxa Comparison Of Avian Telomere Dynamics, Age, And Lifespan, Benjamin Konigsberg May 2025

A Cross-Taxa Comparison Of Avian Telomere Dynamics, Age, And Lifespan, Benjamin Konigsberg

Honors Theses

When eukaryotes replicate cells throughout their life, the end regions of chromosomes naturally degrade as a result of the 5' to 3' directionality of DNA polymerase. There is a point when the chromosome is too damaged to provide normal cellular functions, so the cell will die. Telomeres act as a buffer by providing repetitive sequences of non-coding nucleotides. While telomeres do shorten during replication events, the enzyme telomerase can extend telomeres to prevent senescence. Telomere lengths vary between individuals based on different stressor and stress mitigation. Telomeric rate of change is a metric that can capture telomerase activity by measuring …

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Biophysical Characterization Of Thermophilic Branched-Chain Amino Acid Periplasmic Binding Protein From Thermotoga Maritima, Sky Marsicano May 2025

Biophysical Characterization Of Thermophilic Branched-Chain Amino Acid Periplasmic Binding Protein From Thermotoga Maritima, Sky Marsicano

Honors Theses

Members of the periplasmic binding protein superfamily are involved in the selective passage of ligands through bacterial cell membranes. The hyperthermophilic eubacterium Thermotoga maritima encodes a putative periplasmic branched chain amino acid binding protein (TM1135). The gene was cloned into pET21a(+), overexpressed in Escherichia coli, purified using Ni-NTA chromatography, and confirmed with SDS-PAGE and MALDI mass spectrometry. Biophysical characterization of the protein was performed with fluorescence spectroscopy, absorbance spectroscopy, and circular dichroism experiments to investigate structural stability and ligand binding ability. Using circular dichroism, we demonstrate that TM1135 binds to the branched chain amino acids isoleucine, leucine, and valine, and …

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Isolation And Identification Of Active Antimicrobial Compounds In Alcaligenes And Chromobacterium Strains, Hannah Lwin May 2025

Isolation And Identification Of Active Antimicrobial Compounds In Alcaligenes And Chromobacterium Strains, Hannah Lwin

Honors Theses

ESKAPE pathogens comprise six bacteria that can be highly virulent and are likely to develop antibiotic resistance to many of the currently available antibiotics. New antibiotics are needed to combat these pathogens. Our approach was to isolate and identify antimicrobial compounds from bacteria isolated from soil. Two isolates demonstrating antimicrobial activity were identified as Chromobacterium sp. and Alcaligenes parafaecalis. Preliminary extraction of their antimicrobials was performed.

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Genomic Analysis Of The Lyme Disease Vector Across Virginia’S Spatial Expansion Front, Amy Jablonski May 2025

Genomic Analysis Of The Lyme Disease Vector Across Virginia’S Spatial Expansion Front, Amy Jablonski

Honors Theses

Lyme disease is the most common vector-borne disease in the United States and is expanding with rising incidence in Virginia . This study investigates populations of lxodes scapularis across Virginia using RAD-seq to analyze SNPs from ticks collected in seven Virginia counties and four U.S. states as references . Results show a clear genetic split between western and eastern Virginia ticks . These results follow previously noted patterns in regional differences in Lyme disease risk.

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Fouling-Resistant Voltammetric Xylazine Sensors For Detection Of The Street Drug “Tranq”, Ann Holland Wemple May 2025

Fouling-Resistant Voltammetric Xylazine Sensors For Detection Of The Street Drug “Tranq”, Ann Holland Wemple

Honors Theses

As the opioid crisis continues to wreak havoc on a national and global scale, it is increasingly critical to develop methodologies to detect the most dangerous of these drugs as fentanyl and its derivatives have orders of magnitude higher potency than morphine. Recently, the scientific challenge for chemical detection of fentanyl and its derivatives has been complicated by both the constantly increasing synthetic variations of the drug as well as the expanded use of adulterants. One tragically consequential example is the nocuous street drug known as “Tranq” which combines fentanyl or a fentanyl derivative with the veterinary sedative Rompun®, chemically …

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