Life Sciences Commons^™

La Natividad - Diseños, Glo No. 251, Monterey County, And Associated Historical Documents

Individual Ranchos in Monterey and SLO Counties

Diseños - Hand-drawn Spanish-Mexican map demonstrating the physical boundaries of land granted to Mexican citizens by the Spanish or Mexican.

Expediente – Hand-written Spanish-Mexican land grant document issued to Mexican citizens in Alta California for land in Alta-California.

Work Progress Administration Abstract (WPA Abstract) – A summary document prepared in 1938 under the Work Progress Administration program detailing the history of a rancho beginning with the Spanish-American land through the U.S. patenting process.

Hoffman Notes -- Summary of information concerning claims made for the Rancho lands from the Appendix listing Table of Land Claims in the Reports of Land Cases …

Mission San Miguel Diseños, Glo No. 313, San Luis Obispo County, And Associated Historical Documents

Individual Ranchos in Monterey and SLO Counties

Diseños - Hand-drawn Spanish-Mexican map demonstrating the physical boundaries of land granted to Mexican citizens by the Spanish or Mexican.

Expediente – Hand-written Spanish-Mexican land grant document issued to Mexican citizens in Alta California for land in Alta-California.

Work Progress Administration Abstract (WPA Abstract) – A summary document prepared in 1938 under the Work Progress Administration program detailing the history of a rancho beginning with the Spanish-American land through the U.S. patenting process.

Hoffman Notes -- Summary of information concerning claims made for the Rancho lands from the Appendix listing Table of Land Claims in the Reports of Land Cases …

Los Carneros (Littlejohn) - Diseños, Glo No. 244, Monterey County, And Associated Historical Documents

Individual Ranchos in Monterey and SLO Counties

Diseños - Hand-drawn Spanish-Mexican map demonstrating the physical boundaries of land granted to Mexican citizens by the Spanish or Mexican.

Expediente – Hand-written Spanish-Mexican land grant document issued to Mexican citizens in Alta California for land in Alta-California.

Work Progress Administration Abstract (WPA Abstract) – A summary document prepared in 1938 under the Work Progress Administration program detailing the history of a rancho beginning with the Spanish-American land through the U.S. patenting process.

Hoffman Notes -- Summary of information concerning claims made for the Rancho lands from the Appendix listing Table of Land Claims in the Reports of Land Cases …

Milpitas (Pastor) - Diseños, Glo No. 307, Monterey County, And Associated Historical Documents

Individual Ranchos in Monterey and SLO Counties

Diseños - Hand-drawn Spanish-Mexican map demonstrating the physical boundaries of land granted to Mexican citizens by the Spanish or Mexican.

Expediente – Hand-written Spanish-Mexican land grant document issued to Mexican citizens in Alta California for land in Alta-California.

Work Progress Administration Abstract (WPA Abstract) – A summary document prepared in 1938 under the Work Progress Administration program detailing the history of a rancho beginning with the Spanish-American land through the U.S. patenting process.

Hoffman Notes -- Summary of information concerning claims made for the Rancho lands from the Appendix listing Table of Land Claims in the Reports of Land Cases …

Ex-Mission Soledad Diseños (Mission) - Diseños, Glo No. 294,Monterey County, And Associated Historical Documents

Individual Ranchos in Monterey and SLO Counties

Diseños - Hand-drawn Spanish-Mexican map demonstrating the physical boundaries of land granted to Mexican citizens by the Spanish or Mexican.

Expediente – Hand-written Spanish-Mexican land grant document issued to Mexican citizens in Alta California for land in Alta-California.

Work Progress Administration Abstract (WPA Abstract) – A summary document prepared in 1938 under the Work Progress Administration program detailing the history of a rancho beginning with the Spanish-American land through the U.S. patenting process.

Hoffman Notes -- Summary of information concerning claims made for the Rancho lands from the Appendix listing Table of Land Claims in the Reports of Land Cases …

Llano De Buena Vista - Diseños, Glo No. 266, Monterey County, And Associated Historical Documents

Individual Ranchos in Monterey and SLO Counties

Diseños - Hand-drawn Spanish-Mexican map demonstrating the physical boundaries of land granted to Mexican citizens by the Spanish or Mexican.

Expediente – Hand-written Spanish-Mexican land grant document issued to Mexican citizens in Alta California for land in Alta-California.

Work Progress Administration Abstract (WPA Abstract) – A summary document prepared in 1938 under the Work Progress Administration program detailing the history of a rancho beginning with the Spanish-American land through the U.S. patenting process.

Hoffman Notes -- Summary of information concerning claims made for the Rancho lands from the Appendix listing Table of Land Claims in the Reports of Land Cases …

San Bernabe - Diseños, Glo No. 303, Monterey County, And Associated Historical Documents

Individual Ranchos in Monterey and SLO Counties

Diseños - Hand-drawn Spanish-Mexican map demonstrating the physical boundaries of land granted to Mexican citizens by the Spanish or Mexican.

Work Progress Administration Abstract (WPA Abstract) – A summary document prepared in 1938 under the Work Progress Administration program detailing the history of a rancho beginning with the Spanish-American land through the U.S. patenting process.

Hornbeck Rancho Detail Sheet – A summary sheet generated from a land patent database that details the history of a rancho, along with the various state and federal agency record numbers relating to the rancho.

Bancroft Notes – Document detailing information and documents regarding a …

Los Ojitos - Diseños, Glo No. 311, Monterey County, And Associated Historical Documents

Individual Ranchos in Monterey and SLO Counties

Diseños - Hand-drawn Spanish-Mexican map demonstrating the physical boundaries of land granted to Mexican citizens by the Spanish or Mexican.

Expediente – Hand-written Spanish-Mexican land grant document issued to Mexican citizens in Alta California for land in Alta-California.

Work Progress Administration Abstract (WPA Abstract) – A summary document prepared in 1938 under the Work Progress Administration program detailing the history of a rancho beginning with the Spanish-American land through the U.S. patenting process.

Hoffman Notes -- Summary of information concerning claims made for the Rancho lands from the Appendix listing Table of Land Claims in the Reports of Land Cases …

Los Gatos Or Santa Rita - Diseños, Glo No. 253, Monterey County, And Associated Historical Documents

Individual Ranchos in Monterey and SLO Counties

Diseños - Hand-drawn Spanish-Mexican map demonstrating the physical boundaries of land granted to Mexican citizens by the Spanish or Mexican.

Expediente – Hand-written Spanish-Mexican land grant document issued to Mexican citizens in Alta California for land in Alta-California.

Work Progress Administration Abstract (WPA Abstract) – A summary document prepared in 1938 under the Work Progress Administration program detailing the history of a rancho beginning with the Spanish-American land through the U.S. patenting process.

Hoffman Notes -- Summary of information concerning claims made for the Rancho lands from the Appendix listing Table of Land Claims in the Reports of Land Cases …

Mission Soledad - Diseños, Glo No. 295, Monterey County, And Associated Historical Documents

Individual Ranchos in Monterey and SLO Counties

Diseños - Hand-drawn Spanish-Mexican map demonstrating the physical boundaries of land granted to Mexican citizens by the Spanish or Mexican.

Expediente – Hand-written Spanish-Mexican land grant document issued to Mexican citizens in Alta California for land in Alta-California.

Work Progress Administration Abstract (WPA Abstract) – A summary document prepared in 1938 under the Work Progress Administration program detailing the history of a rancho beginning with the Spanish-American land through the U.S. patenting process.

Hoffman Notes -- Summary of information concerning claims made for the Rancho lands from the Appendix listing Table of Land Claims in the Reports of Land Cases …

Los Carneros (Mcdougal) - Diseños, Glo No. 246, Monterey County, And Associated Historical Documents

Individual Ranchos in Monterey and SLO Counties

Diseños - Hand-drawn Spanish-Mexican map demonstrating the physical boundaries of land granted to Mexican citizens by the Spanish or Mexican.

Expediente – Hand-written Spanish-Mexican land grant document issued to Mexican citizens in Alta California for land in Alta-California.

Work Progress Administration Abstract (WPA Abstract) – A summary document prepared in 1938 under the Work Progress Administration program detailing the history of a rancho beginning with the Spanish-American land through the U.S. patenting process.

Hoffman Notes -- Summary of information concerning claims made for the Rancho lands from the Appendix listing Table of Land Claims in the Reports of Land Cases …

The Gowanus Canal: Delving Into The Murky And Mysterious Waters Of Brooklyn’S Toxic Canal, Victoria L. Von Ancken

Student Theses 2015-Present

Like many environmental issues we face today, the Gowanus Canal began as a hopeful tale. It was envisioned as a promising cargo transportation waterway in Brooklyn, New York. However, due to reckless planning with little thought for the future, the canal slowly began to have a negative effect on its surrounding landscape and community, as well as abandoning its initial purpose, and ultimately sitting stagnant in the neighborhood. Today, the canal is a large environmental problem we face and is in great need of cleanup. The canal is a prime example of a lack of planning and consequential detrimental effects …

Los Coches (Soberanes) - Diseños, Glo No. 296, Monterey County, And Associated Historical Documents

Individual Ranchos in Monterey and SLO Counties

Diseños - Hand-drawn Spanish-Mexican map demonstrating the physical boundaries of land granted to Mexican citizens by the Spanish or Mexican.

Expediente – Hand-written Spanish-Mexican land grant document issued to Mexican citizens in Alta California for land in Alta-California.

Work Progress Administration Abstract (WPA Abstract) – A summary document prepared in 1938 under the Work Progress Administration program detailing the history of a rancho beginning with the Spanish-American land through the U.S. patenting process.

Hoffman Notes -- Summary of information concerning claims made for the Rancho lands from the Appendix listing Table of Land Claims in the Reports of Land Cases …

Los Laureles (Ransom) - Diseños, Glo No. 285, Monterey County, And Associated Historical Documents

Individual Ranchos in Monterey and SLO Counties

Diseños - Hand-drawn Spanish-Mexican map demonstrating the physical boundaries of land granted to Mexican citizens by the Spanish or Mexican.

Expediente – Hand-written Spanish-Mexican land grant document issued to Mexican citizens in Alta California for land in Alta-California.

Work Progress Administration Abstract (WPA Abstract) – A summary document prepared in 1938 under the Work Progress Administration program detailing the history of a rancho beginning with the Spanish-American land through the U.S. patenting process.

Hoffman Notes -- Summary of information concerning claims made for the Rancho lands from the Appendix listing Table of Land Claims in the Reports of Land Cases …

High Salt Induces Anti-Inflammatory Mφ2-Like Phenotype In Peripheral Macrophages, Suneetha Amara, Margaret M. Whalen, Venkataswarup Tiriveedhi

Chemistry Faculty Research

Macrophages play a critical role in inflammation and antigen-presentation. Abnormal macrophage function has been attributed in autoimmune diseases and cancer progression. Recent evidence suggests that high salt tissue micro-environment causes changes in macrophage activation. In our current report, we studied the role of extracellular sodium chloride on phenotype changes in peripheral circulating monocyte/macrophages collected from healthy donors. High salt (0.2M NaCl vs basal 0.1M NaCl) treatment resulted in a decrease in MΦ1 macrophage phenotype (CD11b+CD14highCD16low) from 77.4±6.2% (0.1M) to 29.3±5.7% (0.2M, p<0.05), while there was an increase in MΦ2 macrophage phenotype (CD11b+ CD14lowCD16high) from 17.2±5.9% (0.1M) to 67.4±9.4% (0.2M, p<0.05). ELISA-based cytokine analysis demonstrated that high salt treatment induced decreased expression of in the MΦ1 phenotype specific pro-inflammatory cytokine, TNFα (3.3 fold), IL-12 (2.3 fold), CCL-10 (2 fold) and CCL-5 (3.8 fold), but conversely induced an enhanced expression MΦ2-like phenotype specific anti-inflammatory cytokine, IL-10, TGFβ, CCL-17 (3.7 fold) and CCR-2 (4.3 fold). Further high salt treatment significantly decreased phagocytic efficiency of macrophages and inducible nitric oxide synthetase expression. Taken together, these data suggest that high salt extracellular environment induces an anti-inflammatory MΦ2-like macrophage phenotype with poor phagocytic and potentially reduced antigen presentation capacity commonly found in tumor microenvironment.

Mission Carmelo - Diseños, Glo No. 281, Monterey County, And Associated Historical Documents

Individual Ranchos in Monterey and SLO Counties

Diseños - Hand-drawn Spanish-Mexican map demonstrating the physical boundaries of land granted to Mexican citizens by the Spanish or Mexican.

Expediente – Hand-written Spanish-Mexican land grant document issued to Mexican citizens in Alta California for land in Alta-California.

Work Progress Administration Abstract (WPA Abstract) – A summary document prepared in 1938 under the Work Progress Administration program detailing the history of a rancho beginning with the Spanish-American land through the U.S. patenting process.

Hoffman Notes -- Summary of information concerning claims made for the Rancho lands from the Appendix listing Table of Land Claims in the Reports of Land Cases …

Mission San Antonio (Church Property) - Diseños, Glo No. 308, Monterey County, And Associated Historical Documents

Individual Ranchos in Monterey and SLO Counties

Diseños - Hand-drawn Spanish-Mexican map demonstrating the physical boundaries of land granted to Mexican citizens by the Spanish or Mexican.

Expediente – Hand-written Spanish-Mexican land grant document issued to Mexican citizens in Alta California for land in Alta-California.

Work Progress Administration Abstract (WPA Abstract) – A summary document prepared in 1938 under the Work Progress Administration program detailing the history of a rancho beginning with the Spanish-American land through the U.S. patenting process.

Hoffman Notes -- Summary of information concerning claims made for the Rancho lands from the Appendix listing Table of Land Claims in the Reports of Land Cases …

Development Of A Course-Based Undergraduate Research Experience To Introduce Drug-Receptor Concepts, Hollie I. Swanson, Ok-Kyong Park-Sarge, Thushani Rodrigo-Peiris, Lin Xiang, Vincent M. Cassone

Pharmacology and Nutritional Sciences Faculty Publications

Course-based research experiences (CUREs) are currently of high interest due to their potential for engaging undergraduate students in authentic research and maintaining their interest in science, technology, engineering, and mathematics (STEM) majors. As part of a campuswide initiative called STEMCats, which is a living learning program offered to freshman STEM majors at the University of Kentucky funded by a grant from Howard Hughes Medical Institute, we have developed a CURE for freshmen interested in pursuing health care careers. Our course, entitled “Drug–Drug Interactions in Breast Cancer,” utilized a semester-long, in-class authentic research project and instructor-led discussions to engage students in …

The Effects Of Various Warm-Up Devices On Bat Velocity And Trajectory In Collegiate Baseball Players, Jordan L. Cola

Seton Hall University Dissertations and Theses (ETDs)

Purpose: The purpose of this study was to examine the effects of various weighted warm-up devices on standard baseball bat velocity and trajectory in collegiate baseball players. Methods: Three, right-handed hitters (mean age= 19.3yrs ±1.5yrs; height= 1.74m±.13m; mass=81kg ±20.4kg; baseball experience=14.2 ±1.3) volunteered for this study. Maximal bat velocity was obtained by swinging the 30oz standard bat for the control condition. Participants were then instructed to perform a general and specific warm-up with each of the weighted bats (standard bat with 16oz donut ring (46oz total) and standard bat with 24oz power sleeve (54oz total)) on separate days. Following the …

Filter Feeding, Sam Boven

Graduate School of Art Theses

This paper is an investigation of the mechanics of evolutionary processes and its methods. These investigations are representative of both a world view and a methodology of artistic production. I consider a central consideration of my current work to be the interaction of distinct components and the new experience that these interactions produce when pondered by a viewer. Evolution and the development of life is driven ever forward by the interactions between organisms, both as groups and individuals. By grouping these relationships into three categories: parasitism, predation, and symbiosis, I aim to provide a lens through which to consider both …

Gravid Anopheles Gambiae Sensu Stricto Avoid Ovipositing In Bermuda Grass Hay Infusion And It's Volatiles In Two Choice Egg-Count Bioassays, Lynda K. Eneh, Michael N. Okal, Anna Karin Borg-Karlson, Ulrike Fillinger, Jenny M. Lindh

All Peer-Reviewed Publications

Background: A number of mosquito species in the Culex and Aedes genera prefer to lay eggs in Bermuda grass (Cynodon dactylon) hay infusions compared to water alone. These mosquitoes are attracted to volatile compounds from the hay infusions making the infusions effective baits in gravid traps used for monitoring vectors of arboviral and filarial pathogens. Since Bermuda grass is abundant and widespread, it is plausible to explore infusions made from it as a potential low cost bait for outdoor monitoring of the elusive malaria vector Anopheles gambiae s.s. Methods: This study investigated preferential egg laying of individual An. gambiae s.s. …

Non-Canonical Roles Of Trnas And Trna Mimics In Bacterial Cell Biology, Assaf Katz, Sara Elgamal, Andrei Rajkovic, Michael Ibba

Biology, Chemistry, and Environmental Sciences Faculty Articles and Research

Transfer RNAs (tRNAs) are the macromolecules that transfer activated amino acids from aminoacyl‐tRNA synthetases to the ribosome, where they are used for the mRNA guided synthesis of proteins. Transfer RNAs are ancient molecules, perhaps even predating the existence of the translation machinery. Albeit old, these molecules are tremendously conserved, a characteristic that is well illustrated by the fact that some bacterial tRNAs are efficient and specific substrates of eukaryotic aminoacyl‐tRNA synthetases and ribosomes. Considering their ancient origin and high structural conservation, it is not surprising that tRNAs have been hijacked during evolution for functions outside of translation. These roles beyond …

How Deep Is The Feature Analysis Underlying Rapid Visual Categorization?, Sven Eberhardt, Jonah Cader, Thomas Serre

MODVIS Workshop

Rapid categorization paradigms have a long history in experimental psychology: Characterized by short presentation times and fast behavioral responses, these tasks highlight both the speed and ease with which our visual system processes natural object categories. Previous studies have shown that feed-forward hierarchical models of the visual cortex provide a good fit to human visual decisions. At the same time, recent work has demonstrated significant gains in object recognition accuracy with increasingly deep hierarchical architectures: From AlexNet to VGG to Microsoft CNTK – the field of computer vision has championed both depth and accuracy. But it is unclear how well …

Spatial Synaptic Growth And Removal For Learning Individual Receptive Field Structures, Michael Teichmann, Fred H. Hamker

MODVIS Workshop

One challenge in creating neural models of the visual system is the appropriate definition of the connectivity. The modeler constrains the results with its definition. Unfortunately, there is often just insufficient information about connection sizes available, e.g. for deeper layer or different neuron types like interneurons. Hence, a mechanism refining the connection structure based on the learnings would be appreciated.

Such mechanism can be found in the human brain by structural plasticity. That is, the formation and removal of synapses. For our model, we exploit that synaptic connections are likely to be formed in the proximity of other synapses and …

A Geometric Approach To Sparse Coding Yields Insight Into Nonlinear Responses, Kedarnath Vilankar, James Golden, David Field

MODVIS Workshop

In artificial and biological networks, it is a common accepted practice to describe a neurons (biological or artificial) response properties by a two-dimensional feature map (receptive field). However, real neurons have nonlinear response properties which are not represented by their receptive fields. The efficient coding mechanisms such as sparse coding network or ICA, learn the response properties of V1 neurons from natural images using neural networks. These networks learn the receptive fields which are similar to the receptive fields of V1 neurons. These networks also produces some of the nonlinearities (such as end-stopping and non-classical surround effect), which are exhibited …

The Subjective Experience Of Mild Traumatic Brain Injury In Pediatric Patients, Ruta Clair, Mary Henigan, Sarah Allen, Katy Tresco

Research Day

Mild Traumatic Brain Injury is a neurologic insult that impacts a child’s functioning across domains. Risk factors include previous concussion history, force of impact, and gender. Current research regarding return to school following a brain injury suggests the need for accommodations in a number of areas of learning including changes in schedule, reduced exposure to screens and text, limitations to classroom expectations for tasks such as reading and note-taking, and modified testing. A one-size-fits-all approach to accommodations is problematic as recovery rates vary widely. Studies have also suggested that mood symptoms are comorbid with concussion recovery. Further, pediatric concussion patients …

The Effectiveness Of Coenzyme Q1 And Q10 In Mitigating Myocardial Reperfusion/Ischemia (Mi/R) Injury, Myles Ashitey, Jakob Sutton, Joseph Venditto, Kevin Kucharski, Jason Robbie, Daniel Kuo, Robert Barsotti, Lindon Young, Qian Chen

Research Day

Mitochondria may be a principle source of oxidative stress causing MI/R injury. Coenzyme Q10 (CoQ10) is essential for electron transport in normal mitochondria, has antioxidant properties but its bioavailability is likely reduced due to oxidative stress during MI/R. Coenzyme Q1 (CoQ1) is a derivative of CoQ10, but is a more potent antioxidant than CoQ10 due to a shorter isoprene chain. We hypothesize that CoQ1 will exhibit better cardioprotective effects during MI/R. CoQ1 (MW=250 g/mol; 20 μM, n=5) and CoQ10 (MW=863 g/mol; 20 μM, n=5) were given at reperfusion in isolated rat hearts subjected to I (30 min)/R (45 min). We …

Protein Kinase C (Pkc) Delta Activation Negatively Regulates Phorbol 12-Myristate 13-Acetate (Pma) Induced Superoxide (So) Release In Polymorphonuclear Leukocytes (Pmns), Stephanie Liu, Stephanie Percy, Samuel Johannson, Christine Adekayode, Gregory Stoner, Amelie Bottex, Jovan Adams, Robert Barsotti, Qian Chen

Research Day

It’s known that PMA is a broad-spectrum PKC activator that augments SO release in PMNs viaNADPH oxidase activation. It was shown that PKC delta (δ) negatively regulates PMN elastase release which suggests that PKC δ may also negatively regulate PMN NADPH oxidase SO release. To test the hypothesis, we altered PKC δ activity using selective cell permeable PKC δ activator, inhibitor peptides, and rottlerin, another type of PKC δ inhibitor. We predict that PKC δ activation would attenuate PMA-induced PMN SO release, whereas PKC δ inhibition would augment the response. Isolated PMNs (5x106) from male Sprague-Dawley rats were incubated in …

Financial Toxicity: A Side Effect Of Radiation Therapy For Cancer?, Tejash Patel, Joshua Palmer, Harriet Eldredge-Hindy, John Smyles, Jessie Dinome, Usha Babaria, Richard Stabile, Eric Gressen, Shari Rudoler, Scot Fisher

Research Day

The field of oncology is ever-changing, as new treatment options become available and treatment plans are unceasingly optimized. While the US remains at the forefront of medical innovation and treatment options for serious and complex conditions such as cancer, costs for cancer care are extremely high and continue to increase. Modern healthcare does not come without a price, and medical expenses can have a profound economic impact on American households. Nearly half of bankruptcy filings are in some way a result of medical expenses. While recent healthcare initiatives have increased access to care, many remain underinsured while facing increasing copayments …

Cadaveric And Chart Retrospective On Shoulder Variation: Morphology And Pain, Jeff Capone, Kerin M. Claeson, Lauren Noto-Bell

Research Day

Osteopathic Manipulative Treatment (OMT) is a category of several types of manual techniques used by osteopathic physicians. According to the osteopathic tradition, structure and function are intimately related. This project examined the relationship between shoulder structure and function in an osteopathic framework, with a specific goal to understand how the structure of the acromion affects the development of shoulder injuries. For the first part of this project, cadaveric dissections were performed and muscle diameters were taken of structures within the subacromial space. The second part of this project assessed the efficacy of OMT in shoulder somatic dysfunction for patients treated …