Achievement Goals And Burnout In Pre-Health Profession Undergraduate Students, Jamie Jensen, Hunter Nelson, Grant Rousseau, Kenneth Harrington, Isaiah Aduse-Poku, Alexis Call, Tanner Brown

ScholarsArchive Data

These are survey results of BYU undergraduates who are enrolled in pre-health programs. We assessed their Achievement Goal Orientations and their feelings of Burnout.

Neurodevelopmental And Environmental Mechanisms Of Invasion, Proliferation, And Tumor Cell Fate Specification In Glioblastoma, Bianca Lynn Myers

Biomedical Sciences ETDs

Glioblastomas (GBMs) are the most aggressive primary brain tumors, and despite over 50 years of research efforts, the median survival remains at 14 months post-diagnosis. The current standard of care consists of maximal surgical resection radiotherapy with concurrent chemotherapy using temozolomide. However, the highly proliferative and invasive nature of GBM cells renders total resection nearly impossible as tumor cells invade the surrounding healthy tissue. The molecular and environmental drivers of these tumorigenic phenotypes are largely unknown. Here, we demonstrate that the neurodevelopmental transcription factor ASCL1 enhances tumor cell proliferation and invasion while activating the expression of a neural stem cell …

Mentorship Across A Decade: From Early Career To Mid-Career, Jessica Immonen

The Journal of Integrative Physiology

As a member of the editorial board of the Journal of Integrative Physiology, I was asked to share my reflections on mentoring. The way I functioned as a mentor when I was a junior faculty member was strongly shaped by the mentorship I received through my training years. The way I function as a mentor in my mid-career era has brought pearls from my training mentors but it has become unique to me as a person and a professional.

Mannose: The Hands Of Fate – Overexpressing A Pinus Taeda Hemicellulose Biosynthesis Gene In Populus Tremula × Alba Leads To Increased Height And A Modified Cell Wall Sugar Profile, Joseph Baxter Colbert

Dissertations - ALL

Lignocellulosic biomass as an input for biofuel generation has gained popularity in recent decades due to attainable feedstock ubiquity and an anatomical propensity to fix and sequester carbon. A major challenge facing the integration of such feedstocks is the presence of recalcitrant polymers that are extant in their cell walls, namely lignin and various hemicellulose species. Many studies have illustrated methods in which cell wall modification through genetic means has produced phenotypic improvements with regard to biomaterial generation, though to this point, none have overexpressed exogenous hemicellulose genes to shift the composition of the Populus tremula × alba cell walls. …

The Investigation Of Lateral Foraging Patterns In Fin And Sei Whales, Alex Eschmann

Theses - ALL

Lateralization is the specialization that enhances an organism’s survival by dedicating specific tasks to the hemispheres of the brain, strengthening neural pathways to enhance speed and dexterity of task performance. First described in humans in 1861, lateralization has also been observed in non-human organisms where it often plays a critical role in predator-prey dynamics. Lateralized behaviors for prey foraging, social interactions, and communication have been described in some species of marine mammals from across all three distinct taxonomic orders. In the Order Cetacea, toothed and baleen whale species exhibit lateralized foraging behaviors for prey capture. In this study, I investigated …

Reds Risk In Physically Active Females And Inflammation: Is There A Correlation?, Julia Galindo Sebe

Theses - ALL

Background: Low Energy Availability (LEA) is a key factor in the Female Athlete Triad and Relative Energy Deficiency in Sport (REDs), affecting performance, metabolism, and inflammation. Uric acid (UA), a byproduct of purine metabolism, has been proposed as a potential inflammatory marker. We hypothesize that EA will be inversely correlated with inflammation and that collegiate athletes will exhibit lower EA compared to recreational athletes. Methods: A cross-sectional study was conducted with 51 physically active female college students (18–24 years), including 28 collegiate athletes. LEA risk was assessed using the Low Energy Availability in Females Questionnaire (LEAF-Q), while energy availability (EA) …

Sodium Valproate-Induced Hyperemesis In A Patient Post-Bariatric Surgery, Mohammed Alsubhi, Khalid Alharb, Bandar Alrehaili

Saudi Toxicology Journal

Long-term treatment of patients with medications is associated with adverse drug reactions and continues to be a challenge. Sodium valproate is commonly used to treat bipolar disorder and epilepsy. It can induce adverse gastrointestinal effects, and its absorption may vary depending on the excipient used. In this case study, a middle-aged woman with a history of bipolar disorder developed hyperemesis after the use of a generic sodium valproate formulation. The patient had undergone gastric sleeve surgery 3 years ago and lost weight. Using generic formulation of sodium valproate stimulated vomiting 3 years after the patient had been tolerating the branded …

Effects Of Goat Grazing On Small Mammal Populations, Jordan F. Smith

Science Symposium

Many methods have evolved over the years to attempt to manage invasive Rhamnus cathartica or buckthorn populations. Goat grazing has been shown to be effective at reducing R. cathartica stems, as well as allowing low amounts of viable seeds to pass through goat digestive tracts. Due to small mammal’s prevalence and ecological niche, they are a popular subject for population studies because they can be an indicator of ecological health. This study examined whether or not there was a difference in small mammal populations between a control plot and an experimental plot grazed by goats. Trapping data from 10 days …

Assessing The Long-Term Impact Of Goat Grazing On The Abundance Of Rhamnus Cathartica, Isaac W. Stark

Science Symposium

In years past, high levels of biodiversity and herds of roaming grazing animals maintained a delicate balance between species of plants. More recently due to globalization and deforestation foreign species like Rhamnus cathartica have been able to grow unchecked. Our study uses long term data from periodically goat-grazed areas near Bethel University, MN to evaluate the effectiveness of goat grazing to manage invasive plant species. Random one square meter quadrats were established in 2018 (n=70) to compare the differences in R. cathartica stem density between three height categories (0-30 cm, 30-150 cm, >150 cm), as well as other plant species …

Utilization Of Industrial Hemp Biomass Waste (I): Stability Of Cannabidiol In Pre And Post- Encapsulation States, Jerel Crew, Ying Wu, Richard Mu, Ankit Patras

Food and Animal Sciences Faculty Research

After cannabidiol was extracted from the hemp biomass using supercritical CO2 extraction, the residual could be utilized as a source of other valuable ingredients. The stability of the extracted CBD in pre- and post- encapsulation states were evaluated. Dynamic macerations with ethanol and hexane were compared for CBD extraction. The ethanol extract yielded 0.11% ± 0.10 CBD and 1.83% ± 0.00 cannabidiolic acid (CBDA), while the hexane extraction yielded 0.08% ± 0.04 CBD, 1.06% ± 0.04 CBDA, and 0.30% ± 0.04 delta-9-tetrahydrocannabinol (Δ9-THC). Ethanol extraction was selected due to the low THC detection in the extract. The CBD extract was …

A Framework For Establishing An Automated Traffic Violation Detection System In New Assiut City Using Ordinary Cctv Units, Mahmoud Owais, Ali Shehata, Abdou Shaband, Ghada S. Moussa

Mansoura Engineering Journal

Violating traffic rules in transport networks is a genuine concern for operators as it is one of the most important causes of fatal accidents. With the increasing number of residents in the new cities in the Arab Republic of Egypt, and the incompleteness of the transportation system in those cities, including traffic signs, light signals, and control points, the possibility of committing such violations increases. The study aims to propose the framework for establishing an intelligent monitoring system in the new city of Assiut consisting of high-resolution cameras optimally distributed on the traffic network points in the city. They will …

Exploring The Landscape Of Animal Advocacy In Egypt: Insights Into Stray, Wildlife, And Farmed Animal Rights, Yara Moussa, Wasseem Emam

General - Animal Protection

This article examines the landscape of animal advocacy in Egypt, a nascent and growing field in one of Africa’s largest economies and most densely populated countries. It focuses on three types of animal advocacy: 1) stray animal welfare, 2) wildlife conservation, and 3) farmed animal welfare. The paper critically analyses current practices and trends in each of these areas, highlighting the main challenges and opportunities facing the growth of the movement. Our research draws on insights from interviews with active animal welfare organizations, situating their practical experiences, daily operational struggles, as well as instances of success, within Egypt’s wider socio-economic …

Relationship Between Prodigiosin Production And Batrachochytrium Dendrobatidis Metabolite Concentration, Nautica Ek Hagg

Honors Thesis

Batrachochytrium dendrobatidis (Bd) is a pathogenic fungus that has been causing extirpations of amphibian species across the globe. The microbiome on the skin of amphibians is known to be a key factor in infection dynamics. It has been established that one species of cutaneous bacteria, Serratia marcescens, and a secondary metabolite with antifungal properties it produces, prodigiosin, has shown a promising ability to decrease the growth of Bd. However, when Serratia marcescens is grown in the same media with added metabolites produced by Bd, there is an observed decrease in the production of the bacteria’s protective metabolite, prodigiosin. This experiment …

Wandering From The River: On- And Off-River Abundance Of Interior Least Terns Along The 59-Mile Reach Of The Missouri National Recreational River, Zoe D. Donelan

Honors Thesis

The Interior Least Tern, a summer nesting species native to the sandbars of the Missouri River, faces significant loss of foraging habitat and forage fish populations as a result of modern river regulation. Alternative foraging sites may be located several kilometers from tern nesting colonies at either on-river or off-river wetland sites. To understand how Least Terns use available foraging habitat, we conducted population surveys along the 59-mile reach of the Missouri National Recreational River (MNRR) in Southeastern South Dakota. We conducted land-based surveys at nine on-river public-access sites along the Missouri River and 12 off-river wetland sites within 30 …

Relationship Between Maternal Plasma Retinol And Provitamin A Carotenoids With Fetal And Infant Kidney Development, Anum Akbar

Theses & Dissertations

Vitamin A plays a critical role in fetal organ development. Studies suggest that maternal vitamin A deficiency affects fetal nephron numbers, potentially leading to smaller kidney sizes and an increased risk of chronic kidney disease later in life. However, human studies exploring maternal vitamin A's impact on fetal kidney development lack longitudinal data and within-cohort comparisons. Furthermore, the influence of provitamin A carotenoids (α-carotene, β-carotene, β-cryptoxanthin) on kidney size remains unexplored. This dissertation addresses these gaps by analyzing relationships between maternal and cord plasma retinol and provitamin A carotenoid concentrations with fetal and infant kidney sizes. Our prospective cohort …

Identification And Preclinical Assessment Of Novel Therapeutic Modalities In Environmental Exposure-Induced Lung Disease, Aaron D. Schwab

Theses & Dissertations

Environmental lung diseases are preventable respiratory conditions either caused or made worse by inhaled environmental exposures. Contemporarily, environmental lung diseases are most associated with workplace exposures given specific occupational processes aerosolize inflammatory agents that can be inhaled at high concentrations. Although a considerable amount is known regarding immunoglobulin (Ig)E-mediated responses to environmental exposures, little is known about non-IgE mediated respiratory conditions resulting from lipopolysaccharide (LPS)-enriched organic dust exposure(s). Chronic respiratory diseases such as asthma, hypersensitivity pneumonitis, chronic obstructive pulmonary disease (COPD), and pulmonary fibrosis have all been identified as environmental lung diseases caused or exacerbated by such environmental dusts. Therapeutic …

Cholestasis And Fluid Flow Are Biomechanic Regulators Of Cholangiocarcinoma Progression, Andrew Oleksijew

Theses & Dissertations

Cholestasis, altered or absent bile flow, is associated with poor survival in patients with cholangiocarcinoma, an aggressive cancer of the biliary epithelium. Changes in bile flow often result in stricture or obstruction. Experimental cholestasis promoted tumor growth and progression. However, studies are needed that directly assess the mechanical interaction between bile flow, or bile shear stress, and cholangiocarcinoma signaling. We hypothesized that cholestasis and absent bile shear stress activated cancer signaling and increased aggressive cellular behaviors such as proliferation and migration. Fluid shear stress approximating bile flow was applied by orbital culture plate method and compared to identical static culture …

Intrinsic And Extrinsic Drivers Of Bioaerosol Decay: Investigating Pathogen Stability Of Bacteriophage Ms2, Sin Nombre Virus, And Sars-Cov-2 In Simulated Environments, Elizabeth A. Klug

Theses & Dissertations

The threat posed by a virus as a bioaerosol depends largely on its stability under various environmental conditions (relative humidity (RH), sunlight, ozone, etc.). This stability is typically studied through aerosol decay—how the virus' viability changes over time when exposed environmental conditions. The Goldberg rotating drum, a widely used tool for studying bioaerosols, has been the basis of such research (Goldberg et al., 1958). However, it has significant limitations, including an inability to measure initial pathogen infectivity loss and the use of small sample volumes. Additionally, it does not answer the question of what intrinsic factors (lipids, proteins, nucleic acids) …

Neurodegenerative Disease Mechanisms: Mitochondrial Impairment, Tau Aggregation, And Neuroinflammation As Central Drivers Of Disease Progression, Luis D. Estrella

Theses & Dissertations

The study of the intricate molecular mechanisms behind the pathology of neurodegenerative diseases has become a primary research area in the past decades. The major branches of these studies involve both disease progression and disease pathogenesis, in which neuroscientists have studied, and continue to study, the role that mitochondrial dysfunction, aberrant protein aggregation (like Tau), and immune cell reactions have on these. However, more recent studies have shined light to the fact that these three pathological features are not independent from one another and that their synchronous contributions may be the ultimate driver of neurodegeneration. This dissertation encompasses four different …

Drivers And Mechanisms Of Golgi Fragmentation As A Modulator Of Disease, Amanda Macke

Theses & Dissertations

The Golgi apparatus plays a pivotal role in post-translational modification, trafficking, and secretion of proteins, ensuring proper cellular function. As a result, its fragmentation has been implicated in multiple pathological conditions, including alcohol-induced liver injury and prostate cancer (PCa). Despite its known impact on cellular homeostasis, the molecular mechanisms governing Golgi fragmentation remain to be clarified. Additionally, we have only just begun to understand the vast consequences of Golgi disorganization on disease progression.

This dissertation investigates the drivers and mechanisms of Golgi fragmentation, with a focus on its role as a modulator of disease. Using both in vitro and in …

Investigating The Effects Of Transcription Factor Binding And Genetic Variants In The Striatum Of Post-Mortem Cohorts With Opioid Use Disorder, Rajashree Chakraborty

Theses & Dissertations

The opioid crisis has emerged as one of the most pressing public health challenges of our time, with Opioid Use Disorder (OUD) affecting millions of lives across the globe. Studying OUD is not merely an academic pursuit but a critical necessity in addressing this multifaceted epidemic. The urgency of this research is underscored by the staggering prevalence of OUD, with an estimated 3.7% of U.S. adults requiring treatment in 2022 alone. Despite the availability of effective medications for OUD, a significant treatment gap persists, with only a quarter of those in need receiving these life-saving interventions. The far-reaching consequences of …

Temporal Assessment Of Fish Communities In A South Central Plains Ecoregion Watershed, Tara L. Schnelting

ATU Theses and Dissertations 2021 - Present

Among South Central Plains ecoregion fish communities, there is limited knowledge of the importance of headwaters yet this information is needed to understand their role in fish communities. I addressed this gap by assessing seasonal changes in fish communities in headwater streams of the Moro Creek watershed, Arkansas. I conducted two studies pertaining to temporal fish community assessments: (i) utilize multi-season, community occupancy models to estimate μ (species probability), Ω (community occupancy mean), and p (detection probability) and (ii) utilize beta diversity (β) analyses to address the diversity across different scales in the headwaters of the Moro Creek …

Validating The Ability Of Iag933 To Block The Interaction Of Yap1 And Tead In Ovarian Cancer Cells, Alex Sage

Theses & Dissertations

Ovarian cancer is the most common and deadliest gynecologic malignancy. Approximately 40% of ovarian cancer patients exhibit chemoresistance after receiving initial treatment in the form of neoadjuvant chemotherapy or interval debulking surgery, of which YAP1 (Yes-associated protein 1) has been implicated in enhancing the resistance of ovarian cancer to Cisplatin and Taxol.^1,2. This highlights the need to develop new therapeutic strategies that target the Hippo pathway to overcome resistance to traditional therapies.

YAP1 is a protein that acts as a transcription coregulator, promoting the transcription of genes involved in cellular proliferation and suppressing apoptotic genes. It is a …

Apolipoprotein E4, Tauopathy, And Brain Injury: Molecular Insights Into Alzheimer's Disease Pathology, Nashanthea J. Roland

Theses & Dissertations

Alzheimer’s disease (AD) is the world’s leading cause of dementia, characterized by progressive atrophy of the hippocampal and cortical brain regions, synapse damage and loss, and a buildup of senile plaques and neurofibrillary tangles composed of β-amyloid peptides and hyperphosphorylated tau, respectively. While age is the most significant risk factor for developing AD, apolipoprotein E4 (APOE4) is the strongest genetic risk factor for AD. Although it is known that APOE4 influences tau pathology, the molecular mechanisms by which APOE4 drives AD pathogenesis and progression remain unclear. In addition to intrinsic contributions to AD, there are many extrinsic factors that can …

Claiming More To Cope: Does Ostracism Increase Overclaiming?, Katy Q. Chen

Honors Theses

In a pre-registered online study, we investigated the relationship between ostracism and overclaiming. Ostracism is the act of deliberately or unintentionally excluding and ignoring others. Overclaiming refers to the behavior of exaggerating one’s knowledge or familiarity with specific topics, often as a way of attempting to present oneself as more knowledgeable or competent than one actually is. Drawing from the temporal need-threat model, we hypothesized that ostracized individuals, as a compensatory response, would likely overclaim more compared to included individuals. This online study simulated a work experience where participants were asked to answer questions about their work-related experiences and opinions. …

The Impact Of The Mediterranean Diet On Depression: A Narrative Review, Emma Kate Schaaf

Honors Theses

Background. The Western diet has extensive negative ramifications on physical health and emotional well-being. The Mediterranean diet, widely regarded as one of the healthiest eating patterns in the world, may have the ability to improve psychological conditions. This study aims to examine existing research from randomized control trials (RCTs) on the association between depression prevalence and the Mediterranean diet.

Methods. The following review was conducted using PRISMA guidelines and the Google Scholar and PsycInfo databases. The criteria for inclusion were that studies: 1) were randomized control trials (RCTs) examining the Mediterranean diet; 2) included samples of adults (i.e., > 18 years …

The Impact Of Antimicrobial Peptide Depletion And Fungal Infection On Thermal Preference In Green Frogs, Rana Clamitans, Kim M. Salvador

Honors Theses

Climate change and the disease chytridiomycosis, caused by the fungal pathogen Batrachochytrium dendrobatidis (Bd), are the two main drivers of amphibian decline worldwide, but it is difficult to predict the outcomes of these interacting stressors. Amphibians are ectotherms meaning they are dependent on environmental temperature for the maintenance of physiological processes, and they rely on behavioral thermoregulation to maintain body temperatures within their thermal limits. As the climate becomes more variable, amphibians are also potentially more susceptible to diseases such as Bd, as their immune defenses, such as antimicrobial peptide (AMP) defenses of the skin, take longer to …

Impacts Of Polyploidization On Endocrine Regulation And Vocalization In The Gray Treefrog Complex, Avery Thigpen

Honors Theses

Comparative genomics data suggest that vertebrates are descendants of ancestral polyploids and that historical polyploidization events fueled evolutionary innovations. For example, polyploidization can modify gene expression patterns and/or increase gene mutation rates to alter the phenotype. While considerable emphasis has been placed on the evolutionary impact of ancient polyploidization events, less is known regarding phenotypic modifications in extant polyploids. I examined circulating levels of adrenal glucocorticoids and gonadal steroids in the diploid-tetraploid gray treefrog complex to understand how polyploidization has impacted hormonal regulation. Furthermore, I examined the relationships between levels of these hormones and acoustic signals to examine if and …

The Endocannabinoid System's Influence And Modulation Of Nociception, Doreen M. Flannery

Honors Thesis

The anatomy and physiology of pain is a well-defined pathway where noxious stimuli is processed by different systems in the brain. The central research question of this review is how can we better understand the neurobiological effects pain has, and assess if there is therapeutic potential in using endocannabinoids to modulate these effects. Endocannabinoids are signaling molecules that play a key role at both the cellular and molecular level in modulating both acute and chronic pain by influencing different processes within each level that affect how the body responds to both internal and external stimuli. The endocannabinoid system is a …

Designing An Economically Viable Off-Grid Photovoltaic System Considering The Battery Discharge Rate, Ahmed S. Abdelrazek, Eslam Mohamed Ahmed, Mahmoud Elsisi, Mokhtar Said

Mansoura Engineering Journal

The primary significance of harnessing power from clean and renewable sources lies in the fact that numerous rural areas are far from the utility system. Among the renewable energy technologies catering to power needs in residential areas is the solar photovoltaic (PV) system. Despite the potential of PV technology and the abundant sun radiation exposure in Hurghada, Egypt, there is a lack of empirical studies evaluating the feasibility of off-grid power production using this system. A notable aspect of this study is the consideration of the discharge rate of the battery for sizing the off-grid system, involving the distribution of …