Life Sciences Commons^™

Functional/Activity Network (Fan) Analysis Of Gene-Phenotype Connectivity Liaised By Grape Polyphenol Resveratrol, Tze-Chen Hsieh, Sheng-Tang Wu, Dylan J. Bennett, Barbara B. Doonan, Erxi Wu, Joseph M. Wu

NYMC Faculty Publications

Resveratrol is a polyphenol that has witnessed an unprecedented yearly growth in PubMed citations since the late 1990s. Based on the diversity of cellular processes and diseases resveratrol reportedly affects and benefits, it is likely that the interest in resveratrol will continue, although uncertainty regarding its mechanism in different biological systems remains.We hypothesize that insights on disease-modulatory activities of resveratrol might be gleaned by systematically dissecting the publicly available published data on chemicals and drugs. In this study, we tested our hypothesis by querying DTome (Drug-Target Interactome), a web-based tool containing data compiled from open-source databases including DrugBank, PharmGSK, and …

U.S. Drought Monitor, June 21, 2016, Eric Luebehusen

United States Agricultural Commodities in Drought Archive

Drought map of U.S. for June 21, 2016 (6/21/16) plus: U.S. crop areas experiencing drought (map), Approximate percentage of crop located in drought, by state (bar graph), Percent of crop area located in drought, past 52 weeks (line graph) for: Corn, Soybeans, Hay, Cattle, Winter wheat.

Staphylococcus Aureus Coordinates Leukocidin Expression And Pathogenesis By Sensing Metabolic Fluxes Via Rpirc, Divya Balasubramanian, Elizabeth A Ohneck, Jessica Chapman, Andy Weiss, Min Kyung Kim, Tamara Reyes-Robles, Judy Zhong, Lindsey N. Shaw, Desmond S. Lun, Beatrix Ueberheide, Bo Shopsin, Victor J Torres

Molecular Biosciences Faculty Publications

Staphylococcus aureus is a formidable human pathogen that uses secreted cytolytic factors to injure immune cells and promote infection of its host. Of these proteins, the bicomponent family of pore-forming leukocidins play critical roles in S. aureus pathogenesis. The regulatory mechanisms governing the expression of these toxins are incompletely defined. In this work, we performed a screen to identify transcriptional regulators involved in leukocidin expression in S. aureus strain USA300. We discovered that a metabolic sensor-regulator, RpiRc, is a potent and selective repressor of two leukocidins, LukED and LukSF-PV. Whole-genome transcriptomics, S. aureus exoprotein proteomics, and metabolomic analyses revealed that …

Alcohol Discrimination And Preferences In Two Species Of Nectar-Feeding Primate, Samuel R. Gochman, Michael B. Brown, Nathaniel J. Dominy

Dartmouth Scholarship

Recent reports suggest that dietary ethanol, or alcohol, is a supplemental source of calories for some primates. For example, slow lorises (Nycticebus coucang) consume fermented nectars with a mean alcohol concentration of 0.6% (range: 0.0–3.8%). A similar behaviour is hypothesized for aye-ayes (Daubentonia madagascariensis) based on a single point mutation (A294V) in the gene that encodes alcohol dehydrogenase class IV (ADH4), the first enzyme to catabolize alcohol during digestion. The mutation increases catalytic efficiency 40-fold and may confer a selective advantage to aye-ayes that consume the nectar of Ravenala madagascariensis. It is uncertain, however, whether alcohol exists in this nectar …

Delta Tocotrienol Attenuates Nlrp3 Inflammasome Activation Via Inhibition Of Nf-Κb Priming And Reactive Oxygen Species Generation, Teresa Buckner

College of Education and Human Sciences: Dissertations, Theses, and Student Research

Chronic, low-grade inflammation during obesity is associated with the development of metabolic dysfunction. The NLRP3 inflammasome is assembled in response to cellular stressors and leads to cytotoxic cytokines IL-1β and IL-18 production, which implicates the NLRP3 inflammasome in inflammatory conditions, including type 2 diabetes. Tocotrienols are antioxidant and anti-inflammatory forms of vitamin E. Delta-tocotrienol (dT3) displays NF-κB inhibitory and anti-oxidant abilities, and is easily isolated from the Annatto plant. My primary aim was to determine whether dT3 inhibits NLRP3 inflammasome activation and to compare the extent to which dT3 inhibits NLRP3 inflammasome with other tocotrienol forms, i.e. alpha-tocotrienol (aT3) and …

Assessment Of Streamside Management Zones For Conserving Benthic Macroinvertebrate Communities Following Timber Harvest In Eastern Kentucky Headwater Catchments, Joshua K. Adkins, Christopher D. Barton, Scott Grubbs, Jeffrey W. Stringer, Randall K. Kolka

Forestry and Natural Resources Faculty Publications

Headwater streams generally comprise the majority of stream area in a watershed and can have a strong influence on downstream food webs. Our objective was to determine the effect of altering streamside management zone (SMZ) configurations on headwater aquatic insect communities. Timber harvests were implemented within six watersheds in eastern Kentucky. The SMZ configurations varied in width, canopy retention and best management practice (BMP) utilization at the watershed scale. Benthic macroinvertebrate samples collected one year before and four years after harvest indicated few differences among treatments, although post-treatment abundance was elevated in some of the treatment streams relative to the …

Loss Of Cell Adhesion Increases Tumorigenic Potential Of Polarity Deficient Scribble Mutant Cells, Indrayani Waghmare, Madhuri Kango-Singh

Biology Faculty Publications

Epithelial polarity genes are important for maintaining tissue architecture, and regulating growth. The Drosophila neoplastic tumor suppressor gene scribble (scrib) belongs to the basolateral polarity complex. Loss of scrib results in disruption of its growth regulatory functions, and downregulation or mislocalization of Scrib is correlated to tumor growth. Somatic scribble mutant cells (scrib-) surrounded by wild-type cells undergo apoptosis, which can be prevented by introduction of secondary mutations that provide a growth advantage. Using genetic tools in Drosophila, we analyzed the phenotypic effects of loss of scrib in different growth promoting backgrounds. We investigated if a central …

The Brain Imaging Data Structure, A Format For Organizing And Describing Outputs Of Neuroimaging Experiments, Krzysztof Gorgolewski, Tibor Auer, Vince Calhoun, R Cameron Craddock, Samir Das, Eugene Duff, Guillaume Flandin, Tristan Glatard, Yaroslav Halchenko

Dartmouth Scholarship

The development of magnetic resonance imaging (MRI) techniques has defined modern neuroimaging. Since its inception, tens of thousands of studies using techniques such as functional MRI and diffusion weighted imaging have allowed for the non-invasive study of the brain. Despite the fact that MRI is routinely used to obtain data for neuroscience research, there has been no widely adopted standard for organizing and describing the data collected in an imaging experiment. This renders sharing and reusing data (within or between labs) difficult if not impossible and unnecessarily complicates the application of automatic pipelines and quality assurance protocols. To solve this …

Decision-Making Processes For A Patient Admitted To The Accident And Emergency Department Requiring Emergency Abdominal X-Ray ― A Case Study, Yuliawati Y.

ASEAN Journal on Science and Technology for Development

This study investigated the application of the various processes involved in decision-making for acase requiring radiologic emergency abdominal X-ray examination to the Accident and Emergency Department in a government-owned hospital in West Java, Indonesia. It is also aimed to evaluate the patient who was experiencing abdominal pain accompanied by bloating, vomiting, severe constipation and abdominal cramps.The decision-making models used for this case were the normative, prescriptive and descriptive judgments. A decision tree in the form of decision options that was employed in this case addressed the normative model of decision-making, while the algorithm and information processing theory focused on the …

Guide To The Elk Cove Vineyards Collection, Linfield College Archives

Linfield Archives Finding Aids

This collection is a compilation of various publications, newspapers, and photographs regarding the Elk Cove Vineyards, spanning from its beginnings in 1974 to 2014. The publications all make mention of Elk Cove.

The Farm Newsletter, Usu Student Organic Farm

USU Student Organic Farm Newsletter

Basil-Mint Sauce. Recipe by http://www.eatingwell.com

This healthy herb sauce recipe brings together mint, basil and ground coriander. Use as a healthy sauce for topping chicken, fish or pasta.

1908 August 1 - 1910 August 1, Kingsbury Report, Surveyor General’S Report To Governor Of California

Surveyor General Reports

Annual reports of the Surveyor General to the Governor of California concerning the surveying of state lands, county boundaries, roads, maps, population, agriculture, crops and appropriations.

1910 August 1 - 1912 August 1, Kingsbury Report, Surveyor General’S Report To Governor Of California

Surveyor General Reports

Annual reports of the Surveyor General to the Governor of California concerning the surveying of state lands, county boundaries, roads, maps, population, agriculture, crops and appropriations.

Marine Mammal Behavior: A Review Of Conservation Implications, Philippa Brakes, Sasha R. X. Dall

Social Behavior Collection

The three orders which comprise the extant marine mammals exhibit a wide range of behaviors, varying social structures, and differences in social information use. Human impacts on marine mammals and their environments are ubiquitous; from chemical and noise pollution, to marine debris, prey depletion, and ocean acidification. As a result, no marine mammal populations remain entirely unaffected by human activities. Conservation may be hindered by an inadequate understanding of the behavioral ecology of some of these species. As a result of social structure, social information use, culture, and even behavioral syndromes, marine mammal social groups, and populations can be behaviorally …

De Novo Deciphering Three-Dimensional Chromatin Interaction And Topological Domains By Wavelet Transformation Of Epigenetic Profiles., Yong Chen, Yunfei Wang, Zhenyu Xuan, Min Chen, Michael Q Zhang

College of Science & Mathematics Departmental Research

Defining chromatin interaction frequencies and topological domains is a great challenge for the annotations of genome structures. Although the chromosome conformation capture (3C) and its derivative methods have been developed for exploring the global interactome, they are limited by high experimental complexity and costs. Here we describe a novel computational method, called CITD, for de novo prediction of the chromatin interaction map by integrating histone modification data. We used the public epigenomic data from human fibroblast IMR90 cell and embryonic stem cell (H1) to develop and test CITD, which can not only successfully reconstruct the chromatin interaction frequencies discovered by …

1920 August 1 - Kingsbury Biennial Report, Surveyor General’S Report To Governor Of California

Surveyor General Reports

Annual reports of the Surveyor General to the Governor of California concerning the surveying of state lands, county boundaries, roads, maps, population, agriculture, crops and appropriations.

1902 August 1 - 1904 August 1, Woods Report, Surveyor General’S Report To Governor Of California

Surveyor General Reports

Annual reports of the Surveyor General to the Governor of California concerning the surveying of state lands, county boundaries, roads, maps, population, agriculture, crops and appropriations.

1918 August 1, Kingsbury Biennial Report Including Report On The Torrens Law, Surveyor General’S Report To Governor Of California

Surveyor General Reports

Annual reports of the Surveyor General to the Governor of California concerning the surveying of state lands, county boundaries, roads, maps, population, agriculture, crops and appropriations.

1904 August 1 - 1906 August 1, Woods Report, Surveyor General’S Report To Governor Of California

Surveyor General Reports

Annual reports of the Surveyor General to the Governor of California concerning the surveying of state lands, county boundaries, roads, maps, population, agriculture, crops and appropriations.

1914 August 1 - 1916 August 1, Kingsbury Biennial Report, Surveyor General’S Report To Governor Of California

Surveyor General Reports

Annual reports of the Surveyor General to the Governor of California concerning the surveying of state lands, county boundaries, roads, maps, population, agriculture, crops and appropriations.

1900 August 1 - 1902 August 1, Wright Report, Surveyor General’S Report To Governor Of California

Surveyor General Reports

Annual reports of the Surveyor General to the Governor of California concerning the surveying of state lands, county boundaries, roads, maps, population, agriculture, crops and appropriations.

1912 August 1 - 1914 August 1, Kingsbury Report, Surveyor General’S Report To Governor Of California

Surveyor General Reports

Annual reports of the Surveyor General to the Governor of California concerning the surveying of state lands, county boundaries, roads, maps, population, agriculture, crops and appropriations.

Dynamic Surfaces For The Study Of Mesenchymal Stem Cell Growth Through Adhesion Regulation, Jemma N. Roberts, Jugal Kishore Sahoo, Laura E. Mcnamara, Karl V. Burgess, Jingli Yang, Enateri V. Alakpa, Hilary J. Anderson, Jake Hay, Lesley-Anne Turner, Stephen J. Yarwood, Mischa Zelzer, Richard O.C. Oreffo, Rein V. Ulijn, Matthew J. Dalby

Advanced Science Research Center

Out of their niche environment, adult stem cells, such as mesenchymal stem cells (MSCs), spontaneously differentiate. This makes both studying these important regenerative cells and growing large numbers of stem cells for clinical use challenging. Traditional cell culture techniques have fallen short of meeting this challenge, but materials science offers hope. In this study, we have used emerging rules of managing adhesion/ cytoskeletal balance to prolong MSC cultures by fabricating controllable nanoscale cell interfaces using immobilized peptides that may be enzymatically activated to change their function. The surfaces can be altered (activated) at will to tip adhesion/cytoskeletal balance and initiate …

Freshwater Metaviromics And Bacteriophages: A Current Assessment Of The State Of The Art In Relation To Bioinformatic Challenges, Katherine Bruder, Kema Malki, Alexandria Cooper, Emily Sible, Jason W. Shapiro, Siobhan C. Watkins, Catherine Putonti

Bioinformatics Faculty Publications

Advances in bioinformatics and sequencing technologies have allowed for the analysis of complex microbial communities at an unprecedented rate. While much focus is often placed on the cellular members of these communities, viruses play a pivotal role, particularly bacteria-infecting viruses (bacteriophages); phages mediate global biogeochemical processes and drive microbial evolution through bacterial grazing and horizontal gene transfer. Despite their importance and ubiquity in nature, very little is known about the diversity and structure of viral communities. Though the need for culture-based methods for viral identification has been somewhat circumvented through metagenomic techniques, the analysis of metaviromic data is marred with …

Freshwater Metaviromics And Bacteriophages: A Current Assessment Of The State Of The Art In Relation To Bioinformatic Challenges, Catherine Putonti, Katherine Bruder, Kema Malki, Alexandria Cooper, Emily Sible, Jason W. Shapiro, Siobhan C. Watkins

Biology: Faculty Publications and Other Works

Advances in bioinformatics and sequencing technologies have allowed for the analysis of complex microbial communities at an unprecedented rate. While much focus is often placed on the cellular members of these communities, viruses play a pivotal role, particularly bacteria-infecting viruses (bacteriophages); phages mediate global biogeochemical processes and drive microbial evolution through bacterial grazing and horizontal gene transfer. Despite their importance and ubiquity in nature, very little is known about the diversity and structure of viral communities. Though the need for culture-based methods for viral identification has been somewhat circumvented through metagenomic techniques, the analysis of metaviromic data is marred with …

Smokejumper Obituary: Dickie, Charles W. (North Cascades 1951), National Smokejumper Association

Smokejumper Obituaries

No abstract provided.

The Other Lives Of Ribosomal Proteins, Metrah M. Nader

PSU McNair Scholars Online Journal

Cellular mRNAs are produced in the nucleus and exported to the cytoplasm through nuclear pore complexes (NPC) that are found in the nuclear membrane. The correctly processed mRNAs are exported in the form of messenger ribonucleoproteins (mRNPs). Since the NPC allows the passage of only one mRNA molecule at a time, export of large ribonucleoproteins (megaRNP) found in the nucleus cannot be transported through the NPC. However, a recent study has discovered an alternative export mechanism known as nuclear envelope budding, which allows megaRNP granules to be exported. This study particularly focuses on identifying ribosomal proteins (RPs) found within large …

Gene Expression Patterns Of Bone Morphogenetic Proteins (Bmps) During Early Embryonic Development In The Annual Killifish Austrofundulus Limnaeus, Eva Y. Chan

PSU McNair Scholars Online Journal

The developmental pattern of the annual killifish Austrofundulus limnaeus is unusual compared to other fish. First, the cell movements associated with gastrulation are separated from formation of the embryonic axis. In addition, embryonic diapause can occur. Diapause II and III are often observed when embryos are incubated at 25^oC. Maternal influences and incubation environment are the factors that determine entrance into embryonic diapause, but the molecular mechanisms that regulate diapause are still unknown. Interestingly, embryonic diapause and the unusual cell movements observed during early development are always found together in species of annual killifish that exhibit diapause. Bone …

2010, San Luis Obispo Crop Report.

San Luis Obispo Crop Reports

Annual report pertaining to agriculture in San Luis Obispo County, California.

1871 December 4 - 1873 August 1, Gardner Biennial Report, Surveyor General’S Report To Governor Of California

Surveyor General Reports

Annual reports of the Surveyor General to the Governor of California concerning the surveying of state lands, county boundaries, roads, maps, population, agriculture, crops and appropriations.