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Articles 121801 - 121830 of 255945

Full-Text Articles in Life Sciences

Gang Behavior At Carcasses In Wintering Striated Caracaras (Phalcoboenus Australis) In The Falkland Islands, Anna Rose Autilio Aug 2016

Gang Behavior At Carcasses In Wintering Striated Caracaras (Phalcoboenus Australis) In The Falkland Islands, Anna Rose Autilio

Boise State University Theses and Dissertations

Avian scavengers perform vital ecosystem services by removing waste and by slowing disease. Yet few details are known about the purpose or purposes of social interactions near carcasses and their role in the physical depletion of carcasses (Gangoso et al. 2013). The globally Near-Threatened Striated Caracara is a social scavenging falconid that relies on seabird colonies for food during the breeding season in the Falkland Islands, a principal stronghold in its range. The birds have been persecuted as livestock pests since the late 1800s. Although the population is now protected and remains stable, it does not appear to be growing. …


Switchgrass Cultivar And Intraspecific Diversity Impacts On Nitrogen Use Efficiency, Aislinn Johns Aug 2016

Switchgrass Cultivar And Intraspecific Diversity Impacts On Nitrogen Use Efficiency, Aislinn Johns

Boise State University Theses and Dissertations

Bioenergy feedstock production is an important component of the national renewable energy strategy, which is based on biomass supply. Biofuels for ethanol production may be produced in high-input crop production systems, but the efficacy of these systems for increasing net energy yields over its full life-cycle compared to traditional fuels is under debate, because it is now evident that the benefits of feedstock production are maximized only when biofuels are derived from feedstocks produced with much lower life-cycle greenhouse-gas emissions than traditional fossil fuels. To this end, the reduction of agricultural inputs is key to developing an effective biofuel feedstock …


The Proteolysis Of Apolipoprotein E In Alzheimer's Disease, Julia Love Aug 2016

The Proteolysis Of Apolipoprotein E In Alzheimer's Disease, Julia Love

Boise State University Theses and Dissertations

Harboring the apolipoprotein E4 (APOE4) allele is the greatest genetic risk factor associated with late-onset (sporadic) Alzheimer’s disease (AD), however the mechanism by which apoE4 contributes to the pathology of AD is unknown. The proteolysis of apoE4 has been suggested to contribute to AD pathology due to a possible toxic gain, or loss of function. In order to determine if apoE4 is being cleaved, we designed and characterized a site-directed cleavage antibody directed at position D151 of full length human apoE4. The antibody (nApoECFp17) detected a predicted ~17 kDa fragment following incubation with the proteases Type-1 collagenase, and …


Gyrfalcon Diet During The Brood Rearing Period On The Seward Peninsula, Alaska, In The Context Of A Changing World, Bryce W. Robinson Aug 2016

Gyrfalcon Diet During The Brood Rearing Period On The Seward Peninsula, Alaska, In The Context Of A Changing World, Bryce W. Robinson

Boise State University Theses and Dissertations

As climate change impacts increase so does our need to understand their effects on ecosystem dynamics. I studied Gyrfalcon (Falco rusticolus) diet during the brood rearing period to improve our knowledge on dietary habits during nesting, and provide necessary information for understanding climate change impacts to Arctic ecosystems. I studied diet over two breeding seasons on the Seward Peninsula, Alaska, using two methods: motion-activated cameras and the collection of prey remains. I observed three important dietary shifts: the proportion of ptarmigan in the diet declined significantly throughout the season, the proportion of large prey items declined significantly throughout …


Improving Power Output In Older Adults Utilizing Plyometrics In An Alterg Treadmill, Tyler Dobbs Aug 2016

Improving Power Output In Older Adults Utilizing Plyometrics In An Alterg Treadmill, Tyler Dobbs

Boise State University Theses and Dissertations

The purpose of this study was to compare functional strength and power output in older adults who completed plyometric training in an AlterG treadmill compared to older adults who completed traditional resistance training. Methods: Twenty-three older adults were randomized to a strength (SG), plyometric (PG), or control group (CG). SG and PG exercised 3x/week for 8 weeks while CG performed no exercise. Measures of a timed sit-to-stand, stair climb, estimated maximal muscular strength, and isokinetic power were taken at pre and post testing. A repeated measures 2x3 (time x group) ANOVA was used to determine if there was a significant …


An Investigation Of Herbivory And Seed Predation On Slickspot Peppergrass, Michelle I. Jeffries Aug 2016

An Investigation Of Herbivory And Seed Predation On Slickspot Peppergrass, Michelle I. Jeffries

Boise State University Theses and Dissertations

This study was completed during the summers of 2014 and 2015 to continue research on the relationship between harvester ants (Pogonomyrmex salinus) and slickspot peppergrass (Lepidium papilliferum). Slickspot peppergrass is a rare mustard endemic to south western Idaho. Over the past century, the species has declined in abundance, largely as a result of habitat degradation and fragmentation. In addition to these reasons for decline, seed foraging by harvester ants and plant destruction by harvester ants and small mammal herbivores have been recently indicated as potential factors. This study confirmed that harvester ants remove large numbers of …


Genetic Analysis Of Eurasian Populations Of Taeniatherum Caput-Medusae Subspecies Asperum: Biogeography Of An Invasive, Self-Pollinating, Annual Grass In Its Native Range, Peter Guerdan Aug 2016

Genetic Analysis Of Eurasian Populations Of Taeniatherum Caput-Medusae Subspecies Asperum: Biogeography Of An Invasive, Self-Pollinating, Annual Grass In Its Native Range, Peter Guerdan

Boise State University Theses and Dissertations

Understanding species’ distributions provides a comprehensive biogeographical framework with which to evaluate theoretical and applied ecological and evolutionary questions. To date, few studies have used amplified fragment length polymorphisms (AFLPs) to assess the biogeographical patterns of a broadly distributed grass species, and none that I have found used AFLPs to specifically study biogeographical patterns of an invasive annual grass in its native range. The overall objective of my study was to assess the biogeographic pattern of the invasive, self-pollinating, annual grass Taeniatherum caput-medusae subspecies asperum (medusahead) in its native range in Eurasia using AFLPs. Seventy populations of medusahead from 13 …


Earlier Nesting By A Predatory Bird Is Associated With Human Adaptations To Climate Change, Shawn Heath Smith Aug 2016

Earlier Nesting By A Predatory Bird Is Associated With Human Adaptations To Climate Change, Shawn Heath Smith

Boise State University Theses and Dissertations

Advancing growing seasons and prey abundance drive earlier breeding in dietary specialists because, ultimately, consumers benefit by timing their reproduction to coincide with peak prey abundance. The selective pressure to breed earlier may be lower for species that forage on diverse prey items that vary in abundance both spatially and temporally. The selective pressure may be reduced further if predators have access to a mosaic of habitats, each of which having different shifts in growing seasons. We studied whether earlier breeding of a predatory generalist, the American kestrel (Falco sparverius) nesting in a mosaic of habitat types was …


Evaluation Of Agricultural Policy In The Dairy Sector In Kosovo And Efficiency Analysis At The Farm Level, Egzon Bajrami Aug 2016

Evaluation Of Agricultural Policy In The Dairy Sector In Kosovo And Efficiency Analysis At The Farm Level, Egzon Bajrami

Graduate Theses and Dissertations

This thesis consists of two studies on the dairy sector in Kosovo. The first study evaluates the effect of the Subsidy per Head Scheme (SPHS) on increasing production, land use, gross income and number of dairy cows on dairy farms in Kosovo. Results from the Propensity Score Matching (PSM) approach using four alternative matching algorithms revealed that SPHS has not had any impact on increasing land use, gross income or the number of dairy cows per farm. Furthermore, SPHS had a negative impact on decreasing land use and number of cows for the participating dairy farmers in the program. In …


Using Plant-Soil Feedbacks To Predict Plant Biomass In Diverse Communities, Andrew Kulmatiski, Karen H. Beard, Josephine Grenzer, Leslie E. Forero, Justin Heavilin Aug 2016

Using Plant-Soil Feedbacks To Predict Plant Biomass In Diverse Communities, Andrew Kulmatiski, Karen H. Beard, Josephine Grenzer, Leslie E. Forero, Justin Heavilin

Wildland Resources Faculty Publications

http://onlinelibrary.wiley.com/wol1/doi/10.1890/15-2037.1/abstract


B. R. Wells Arkansas Rice Research Studies 2015, R. J. Norman, K.A. K. Moldenhauer Aug 2016

B. R. Wells Arkansas Rice Research Studies 2015, R. J. Norman, K.A. K. Moldenhauer

Arkansas Agricultural Experiment Station Research Series

No abstract provided.


Regulation Of Pyrroloquinoline Quinone-Dependent Glucose Dehydrogenase Activity In The Model Rhizosphere-Dwelling Bacterium Pseudomonas Putida Kt2440, Ran An, Luke Moe Aug 2016

Regulation Of Pyrroloquinoline Quinone-Dependent Glucose Dehydrogenase Activity In The Model Rhizosphere-Dwelling Bacterium Pseudomonas Putida Kt2440, Ran An, Luke Moe

Plant and Soil Sciences Faculty Publications

Soil-dwelling microbes solubilize mineral phosphates by secreting gluconic acid, which is produced from glucose by a periplasmic glucose dehydrogenase (GDH) that requires pyrroloquinoline quinone (PQQ) as a redox coenzyme. While GDH-dependent phosphate solubilization has been observed in numerous bacteria, little is known concerning the mechanism by which this process is regulated. Here we use the model rhizosphere-dwelling bacterium Pseudomonas putida KT2440 to explore GDH activity and PQQ synthesis, as well as gene expression of the GDH-encoding gene (gcd) and PQQ biosynthesis genes (pqq operon) while under different growth conditions. We also use reverse transcription-PCR to identify transcripts …


South Padre Island Beach Management: Assessment Of Dune Restoration, Shelby Rose Bessette Aug 2016

South Padre Island Beach Management: Assessment Of Dune Restoration, Shelby Rose Bessette

Theses and Dissertations

Dune restoration is a common method of increasing coastal resilience. A dune restoration program was initiated by the City of South Padre Island, TX in 2010 consisting primarily of plantings of Sea Oats, Uniola paniculata, and Bitter Panicum, Panicum amarum and has continued approximately annually thereafter. These restoration efforts were evaluated in this study by comparing dune ecological structure and function among reference sites and restoration plots ranging in age from 2 to 5 years. Plant and animal communities were examined using a combination of quadrat sampling, funnel traps, pit-falls and sweep nets. Soil organic content and soil electric …


Relationship Between Lower Body Strength, Countermovement Jump Height, And Optimal Drop Jump Drop Height, Cameron V. Griggs Aug 2016

Relationship Between Lower Body Strength, Countermovement Jump Height, And Optimal Drop Jump Drop Height, Cameron V. Griggs

Electronic Theses and Dissertations

The purpose of this study was to understand the relationship between back squat one-repetition maximum relative to body mass (1RMrel), countermovement jump height (CMJH), and optimal drop height in drop jump (DHopt). Fifteen male participants with various sport backgrounds and training experience completed a one repetition maximum (1RM) back squat, maximum countermovement jump (CMJ), and drop jumps (DJ) from incrementally increasing drop heights to determine which drop height elicited the greatest jump height. The DHopt testing protocol was unique in that smaller increments were used to determine DHopt compared to what has been reported in literature previously. Pearson correlation coefficients …


Long-Term Supplementation With Leucine Does Not Prevent Development Of Obesity In Rats Fed A High-Fat Diet, Dameon Smith Aug 2016

Long-Term Supplementation With Leucine Does Not Prevent Development Of Obesity In Rats Fed A High-Fat Diet, Dameon Smith

Graduate Theses and Dissertations

Excess dietary fat consumption has been implicated in the development of obesity and diabetes. Obesity can be characterized by a disproportionate increase in fat mass compared to lean body mass. However, if muscle mass can be increased or maintained in obesity, this may facilitate weight loss by increasing the body’s overall metabolic capacity. Historically, supplementation with the branched-chain amino acid leucine has been shown to increase muscle protein synthesis via the protein kinase mTORC1. Recent studies suggest that supplementation with leucine also has the potential to reduce weight gain and fat deposition in high-fat fed, obese mice. The objective of …


Regulation Of Breast Cancer Initiation And Progression By 14-3-3zeta, Chia-Chi Chang Aug 2016

Regulation Of Breast Cancer Initiation And Progression By 14-3-3zeta, Chia-Chi Chang

Dissertations and Theses (Open Access)

14-3-3ζ is a ubiquitously expressed family member of proteins that have been implicated to have oncogenic potential through its interactions and involvement in cancer initiation and progression. 14-3-3ζ belongs to the highly conserved 14-3-3ζ protein family and modulates numerous pathways in cancer. Overexpression of 14-3-3ζ is an early event, occurs in more than 40% of human breast cancer cases, and is associated with disease recurrence and poor prognosis. Metabolic reprogramming is a hallmark of cancer. Cancer cells elevate aerobic glycolysis to produce metabolic intermediates and reducing equivalents, thereby facilitating cellular adaptation to the adverse environment and sustaining fast proliferation. Interestingly, …


Active Parental Care, Reproductive Performance, And A Novel Egg Predator Affecting Reproductive Investment In The Caribbean Spiny Lobster Panulirus Argus, J. Antonio Baeza, Lunden Simpson, Louis J. Ambrosio, Nathalia Mora, Rodrigo Guéron, Michael J. Childress Aug 2016

Active Parental Care, Reproductive Performance, And A Novel Egg Predator Affecting Reproductive Investment In The Caribbean Spiny Lobster Panulirus Argus, J. Antonio Baeza, Lunden Simpson, Louis J. Ambrosio, Nathalia Mora, Rodrigo Guéron, Michael J. Childress

Publications

Background

We used the Caribbean spiny lobster Panulirus argus, one of the largest brooding invertebrates in the Western Atlantic, to test for the presence/absence of active parental care and to explore reproductive performance in large brooding marine organisms. Given [i] the compact and large embryo masses produced by P. argus, [ii] the expected disproportional increase in brooding costs with increasing embryo mass size, and [iii] the theoretical allometry of egg production with increasing body size, we predicted that parental females in this large species will engage in active brood care. We also predicted that larger broods from larger …


Loss Of Exogenous Androgen Dependence By Prostate Tumor Cells Is Associated With Elevated Glucuronidation Potential, Brenna M. Zimmer, Michelle E. Howell, Qin Wei, Linlin Ma, Trevor Romsdahl, Eileen G. Loughman, Jennifer E. Markham, Javier Seravalli, Joseph J. Barycki, Melanie A. Simpson Aug 2016

Loss Of Exogenous Androgen Dependence By Prostate Tumor Cells Is Associated With Elevated Glucuronidation Potential, Brenna M. Zimmer, Michelle E. Howell, Qin Wei, Linlin Ma, Trevor Romsdahl, Eileen G. Loughman, Jennifer E. Markham, Javier Seravalli, Joseph J. Barycki, Melanie A. Simpson

Department of Biochemistry: Faculty Publications

Prostate epithelial cells control the potency and availability of androgen hormones in part by inactivation and elimination. UDP-glucose dehydrogenase (UGDH) catalyzes the NAD+-dependent oxidation of UDP-glucose to UDP-glucuronate, an essential precursor for androgen inactivation by the prostate glucuronidation enzymes UGT2B15 and UGT2B17. UGDH expression is androgen stimulated, which increases the production of UDP-glucuronate, and fuels UGT-catalyzed glucuronidation. In this study, we compared the glucuronidation potential and its impact on androgen-mediated gene expression in an isogenic LNCaP model for androgen dependent versus castration resistant prostate cancer. Despite significantly lower androgen-glucuronide output, LNCaP 81 castration resistant tumor cells expressed higher …


Cryptosporidium Parvum Among Coprolites From La Cueva De Los Muertos Chiquitos (600–800 Ce), Rio Zape Valley, Durango, Mexico, Johnica J. Morrow, Karl Reinhard Aug 2016

Cryptosporidium Parvum Among Coprolites From La Cueva De Los Muertos Chiquitos (600–800 Ce), Rio Zape Valley, Durango, Mexico, Johnica J. Morrow, Karl Reinhard

Karl Reinhard Publications

In the present study, 90 coprolites from La Cueva de los Muertos Chiquitos (CMC) were subjected to enzyme-linked immunosorbent assay (ELISA) tests for 3 diarrhea-inducing protozoan parasites, Entamoeba histolytica, Giardia duodenalis, and Cryptosporidium parvum, to determine whether these parasites were present among the people who utilized this cave 1,200–1,400 yr ago. These people, the Loma San Gabriel, developed as a culture out of the Archaic Los Caracoles population and lived throughout much of present-day Durango and Zacatecas in Mexico. The Loma San Gabriel persisted through a mixed subsistence strategy of hunting-gathering and agricultural production. The results of …


The Effects Of 4-Nonylphenol On The Immune Response Of The Pacific Oyster, Crassostrea Gigas, Following Bacterial Infection (Vibrio Campbellii), Courtney Hart Aug 2016

The Effects Of 4-Nonylphenol On The Immune Response Of The Pacific Oyster, Crassostrea Gigas, Following Bacterial Infection (Vibrio Campbellii), Courtney Hart

Master's Theses

Endocrine disrupting chemicals (EDCs) are compounds that can interfere with hormone signaling pathways and are now recognized as pervasive in estuarine and marine waters. One prevalent EDC in California’s coastal waters is the xenoestrogen 4-nonylphenol (4-NP), which has been shown to impair reproduction, development, growth, and in some cases immune function of marine invertebrates. To further investigate effects of 4-NP on marine invertebrate immune function we measured total hemocyte counts (THC), relative transcript abundance of immune-relevant genes, and lysozyme activity in Pacific oysters (Crassostrea gigas) following bacterial infection. To quantify these effects we exposed oysters to dissolved phase …


The Effectiveness Of Periodically-Harvested Closures In Meeting Ecological And Socioeconomic Objectives, Paul G. Carvalho Aug 2016

The Effectiveness Of Periodically-Harvested Closures In Meeting Ecological And Socioeconomic Objectives, Paul G. Carvalho

Master's Theses

Periodically-harvested fisheries closures (PHCs) are a widespread form of community-based marine spatial management used throughout the Indo-Pacific that also is currently being intensively advocated by conservation organizations for supporting productive fisheries and healthy marine ecosystems. However, local implementation of PHCs has historically been designed to support occasional and efficient exploitation of fish stocks, and not necessarily sustainable fisheries yields and stock conservation. The efficacy of PHCs for achieving their historical cultural objectives of periodicity and efficiency of harvest, simultaneously with achieving contemporary fisheries objectives of fisheries productivity and conservation is undetermined. As a result, the utility of PHCs for supporting …


Effects Of Experimental Noise Exposure On Songbird Nesting Behaviors And Nest Success, Tracy I. Mulholland Aug 2016

Effects Of Experimental Noise Exposure On Songbird Nesting Behaviors And Nest Success, Tracy I. Mulholland

Master's Theses

Anthropogenic noise is an increasingly prevalent global disturbance. Animals that rely on the acoustical environment, such as songbirds, are especially vulnerable to these sounds. Traffic noise, in particular, overlaps with the frequency range of songbirds, creating masking effects. We investigated the effects of chronic traffic noise on provisioning behaviors and breeding success of nesting western bluebirds (Sialia mexicana) and ash-throated flycatchers (Myiarchus cinerascens). Because anthropogenic noise exposure has the potential to interrupt parent-offspring communication and alter vigilance behaviors, we predicted that traffic noise would lead to changes in provisioning behaviors, such as fewer visits to the …


The Preservation And Protection Of Native Biodiversity In The Guadalupe Nipomo Dunes Complex, Lindsey M. Whitaker, Matthew Ritter, Scott J. Steinmaus, Jonathan Hall Aug 2016

The Preservation And Protection Of Native Biodiversity In The Guadalupe Nipomo Dunes Complex, Lindsey M. Whitaker, Matthew Ritter, Scott J. Steinmaus, Jonathan Hall

Master's Theses

The Guadalupe Nipomo Dunes Complex (GNDC) is located within the California Floristic Province, a biodiversity hotspot characterized by high rates of endemism and exceptional loss of habitat. In 1980, the US Fish and Wildlife Service described the GNDC as, “the most unique and fragile ecosystem in the State of California,” and ranked it first on a list of 49 habitat areas needing state protection. It is the largest coastal dune area in California and it is one of the last remaining, relatively intact ecosystems of its type and size in the western United States. The growing recognition of species decline …


Ecological And Phenotypic Factors Influencing The Movement Dynamics Of The Blackspotted Topminnow, Fundulus Olivaceus, Scott Richard Clark Aug 2016

Ecological And Phenotypic Factors Influencing The Movement Dynamics Of The Blackspotted Topminnow, Fundulus Olivaceus, Scott Richard Clark

Dissertations

Movement of individuals throughout a landscape is a complex behavior that has important consequences on numerous ecological and evolutionary processes. Perhaps most notably is the relationship between movement and reproduction, as this has implicit ramifications on individual fitness and consequently, population level processes. Although this relationship has been theoretically and empirically demonstrated across a number of animal taxa, its role in fishes remains understudied and largely unknown. Using a series of outdoor mesocosms, in combination with a field study, I employed passive integrated transponder (PIT) tags to experimentally assess the sex-specific movement dynamics of a small-bodied, sexually-dimorphic stream fish, the …


Analysis Of The Intricacies Of Substrate Recognition Of High Mobility Group Proteins And Aminoacyl-Trna Synthetases Using Non-Cognate Substrates, Douglas Van Iverson Ii Aug 2016

Analysis Of The Intricacies Of Substrate Recognition Of High Mobility Group Proteins And Aminoacyl-Trna Synthetases Using Non-Cognate Substrates, Douglas Van Iverson Ii

Dissertations

The studies presented in section 1 (Chapters I-IV) focus on the design and development of nucleic acid four-way junctions (4WJs) to target a member of the high mobility group (HMG) proteins, the proinflammatory cytokine high mobility group box 1 protein (HMGB1). In the present study, hybrid PNA-DNA 4WJs based on a model DNA 4WJ were constructed to improve the thermal stability of 4WJs while maintaining strong binding affinity toward HMGB1. An electrophoretic mobility shift assay (EMSA) was used to examine the binding affinity of an isolated DNA binding domain of HMGB1, the HMGB1 b-box (HMGB1b), toward a set of PNA-DNA …


Three Siblings With Familial Non-Medullary Thyroid Carcinoma: A Case Series, Muhammad Owais Rashid, Naeemul Haq, Saad Farooq, Zareen Kiran,, Sabeehuddin Siddique, Shahid Pervez, Najmul Islam Aug 2016

Three Siblings With Familial Non-Medullary Thyroid Carcinoma: A Case Series, Muhammad Owais Rashid, Naeemul Haq, Saad Farooq, Zareen Kiran,, Sabeehuddin Siddique, Shahid Pervez, Najmul Islam

Department of Pathology and Laboratory Medicine

Background: In 2015, thyroid carcinoma affected approximately 63,000 people in the USA, yet it remains one of the most treatable cancers. It is mainly classified into medullary and non-medullary types. Conventionally, medullary carcinoma was associated with heritability but increasing reports have now begun to associate non-medullary thyroid carcinoma with a genetic predisposition as well. It is important to identify a possible familial association in patients diagnosed with non-medullary thyroid carcinoma because these cancers behave more destructively than would otherwise be expected. Therefore, it is important to aggressively manage such patients and screening of close relatives might be justified. Our case …


Dissemination And Spread Of New Delhi Metallo-Beta-Lactamase-1 Superbugs In Hospital Settings, Erum Khan, Seema Irfan, Binish Arif Sultan, Amna Nasir, Rumina Hasan Aug 2016

Dissemination And Spread Of New Delhi Metallo-Beta-Lactamase-1 Superbugs In Hospital Settings, Erum Khan, Seema Irfan, Binish Arif Sultan, Amna Nasir, Rumina Hasan

Department of Pathology and Laboratory Medicine

Objective:
To find out frequency of isolation of carbapenem-resistant enterobacteriaceae and the predominantly responsible metallo-beta-lactamasegene in a hospital setting.
Methods:
The descriptive, cross-sectional study was conducted from May 2009 to June 2012 at the Aga Khan University Hospital, Karachi, and comprised non-duplicate clinical carbapenem-resistant enterobacteriaceae isolates obtained from different collection units across Pakistan. Kirby-Bauer disk diffusion screening of carbapenem-resistant enterobacteriaceae was confirmed by minimum inhibitory concentration using E-test. Polymerase chain reaction assay was performed to detect blaKPC, blaNDM-1, blaIMP, and blaVIM genes. In addition variable number tandem repeat typing was performed on selected cluster of New Delhi metallo-beta-lactamase-1- positive …


The Impact Of Cortical State On Neural Coding And Behavior, Charles Beaman Aug 2016

The Impact Of Cortical State On Neural Coding And Behavior, Charles Beaman

Dissertations and Theses (Open Access)

The brain is never truly silent – up to 80% of its energy budget is expended during ongoing activity in the absence of sensory input. Previous research has shown that sensory neurons are not exclusively influenced by external stimuli but rather reflect interactions between sensory inputs and the ongoing activity of the brain. Yet, whether fluctuations in the state of cortical networks influence sensory coding in neural circuits and the behavior of the animal are unknown. To shed light on this issue, we conducted multi-unit electrophysiology experiments in visual areas V1 and V4 of behaving monkeys. First, we studied the …


Development Of An In Silico Kir Genotyping Algorithm And Its Application To Population And Cancer Immunogenetic Analyses, Howard Rosoff Aug 2016

Development Of An In Silico Kir Genotyping Algorithm And Its Application To Population And Cancer Immunogenetic Analyses, Howard Rosoff

Dissertations and Theses (Open Access)

Gene content determination and variant calling in the complex KIR genomic region are useful for immune system function analysis, pathogenesis and disease risk factor elucidation, immunotherapy development, evolutionary investigations, and human migration modeling. Sequence-specific oligonucleotide and sequence-specific primer PCR methods are the de facto standards for KIR presence/absence identification, but the current platforms are unsuitable for SNP calling, impractical for KIR typing large cohorts of DNA samples, and inapplicable for typing repositories in which sequence data, but not cells or cell analytes, are available. Alternative typing methods, such as in silico sequence-based typing, can address the problems associated with amplicon-based …


Investigating The Roles Of Δnp63 As A Suppressor Of Migration, Invasion, And Metastasis, Ramon E. Flores Gonzalez Aug 2016

Investigating The Roles Of Δnp63 As A Suppressor Of Migration, Invasion, And Metastasis, Ramon E. Flores Gonzalez

Dissertations and Theses (Open Access)

Cancer is one of the leading causes of death and disease in the world. Considerable resources are spent to study and understand cancer, with the hope of developing new treatments and eventually cures that will help millions of people. Efforts to understand cancer are hindered by its inherent complexity and instability. Nonetheless, understanding the basics of tumor development and progression are the key to focused on studying the role of ΔNp63 in cancer, a p53 family member known to be involved in epithelial development, microRNA biogenesis, and stem cell maintenance. Using the strength of in vivo mouse models, we found …