Life Sciences Commons^™

Bibliometric Analysis Of Research Trends Related To Human Immunodeficiency Virus., Madyson E. Johnson, Kaitlyn R. Coffman, Valerie Rivas, Elizabeth Barrett

ATU Scholars Symposium

Human immunodeficiency virus poses major health burden across the globe including the United States of America and has its zoonotic origin from the Simian Immunodeficiency viruses of sooty mangabey monkey and chimpanzee in Africa. Epidemiological trends indicate that even though the mortality rates for HIV are falling globally, the rates of new cases have been rising since 2010 in several countries including the USA. An estimated 0.5% of the human population is currently infected with the virus with countries like USA, India, Nigeria and South Africa carrying the highest burden of the disease. Host receptors such as CD4 and coreceptors …

Discovering And Characterizing Novel Temperate Bacteriophage Infecting Arthrobacter Globiformis B-2979, Paige M. Baldwin, Michael Bennet, Evangelia A. Buonamici, Hanan E. Isik, Niran E. Isik, Vienna Li, Mia R. Mazakas, Aaryan M. Modi, Nikita Muppoor, Kylie A. Oliver, Vidhi M. Patel, Kylie Tabak, Jamie K. Yu, Laura Weber

STEM Student Research Symposium Posters

AmiCi24 is a novel temperate bacteriophage collected from a soil sample originating in Sewell, NJ, USA and cultivated with Arthrobacter globiformis B-2979. AmiCi24 is a Siphoviridae morphotype, belonging to the cluster AS and subcluster of AS3. The AmiCi24 genome consists of 38,466 basepairs, encoding 68 genes.

Evaluation Of Valid Vo2max Criteria For Graded Exercise Testing In Cancer Survivors, Daniel Y.K. Shackelford, Jessica M. Brown, Rhianna N. Patel

International Journal of Exercise Science

International Journal of Exercise Science 18(5): 443-455, 2025. Cardiovascular fitness (VO_2max) predicts all-cause mortality and is vital to assess in cancer survivors (CS) for individualized exercise prescriptions. Metabolic carts confirm VO_2max with respiratory exchange ratio (RER) >1.10; other VO_2max criteria include ≤10 beats/minute of maximal predicted heart rate and/or a rating of perceived exertion (RPE) of >8 on the Modified Borg Scale. Another suggested criterion is respiratory frequency (Rf) > 40 breaths per minute. These criteria are assumed applicable for all populations, but due to cancer-related toxicities, frequency and validity of traditional VO_2max criteria usage in …

Influence Of Biting Flies On The Growth And Condition Of Nestling Eastern Bluebirds, Ella Grace Bollinger

ATU Scholars Symposium

Habitat alteration and climate change are expected to increase the range, abundance, and season length of ectoparasites and the pathogens they carry. This is particularly concerning for nestling birds that are relatively naked and immobile, making them vulnerable to attacks by biting flies such as blackflies and mosquitoes. Despite the ubiquity of biting flies and the challenges they pose to nestlings, studies investigating their association with breeding birds remain rare. To address this, we propose a series of observational and experimental field studies with Eastern Bluebirds (Sialia sialis) to investigate the attraction of biting flies to active nests …

Investigating Silicon As A Candidate For Plant Synthetic Biology, Stephanie N. Nelms, Kai Herring, Luke Hanke, William Foley

ATU Scholars Symposium

The physicochemical properties of silicon are closely related to carbon. Certain species of plants accumulate high amount of silicon, however, their physiological role and molecular mechanism of sequestration and distribution in plant tissues are poorly understood. The bonding potential of silicon is analogous to carbon and silicon is a key element propelling nanotechnology and digital revolution. Recent discoveries of silicon in Mars and the Moon along with metabolic engineering of enzymes that can incorporate and cleave silicon from organic compounds have consolidated the idea of silicon-based synthetic cellular lifeforms. Bibliometric analysis was used to evaluate the trend of research in …

Using Guano To Determine Ozark Big-Eared Bat Cave Occupancy In Arkansas​, Lark E. Sybrant

ATU Scholars Symposium

The Ozark big-eared bat (Corynorhinus townsendii ingens) is endangered in Arkansas and is known to have small populations, range restrictions, and specific habitat requirements in the Ozark-St. Francis National Forest. Beyond their known range, there are other potentially suitable areas that have not been confirmed. We aim to test whether the non-invasive genetic analysis of guano samples can identify Ozark big-eared bat cave use and expand their known range. Additional locations need to be surveyed to ensure site protection, as unknown caves are susceptible to human disturbance and damage. Twenty-five sites were surveyed at the southeastern extent of their known …

Impact Of Community Gardening On Neighborhood Crime Rates: Research Proposal, Abby J. Cutsinger

ATU Scholars Symposium

Gardening has been a part of human existence from the beginning of time, but people have become distanced from gardening as civilization has grown and urbanized. As this distance has grown, so has the disconnect between people and the basic needs which shape their views of themselves and of society. It is possible that, in the drift away from gardening as communities, humans have become less moral.

The purpose of this study is to determine if community gardening lowers violent crime rates.

This relationship will be gauged by answering the following questions:

• Which type of community gardening benefits community relationships …

Using Environmental Dna To Evaluate The Distribution And Abundance Of Western Chicken Turtles, Kai D. Scarangella

ATU Scholars Symposium

The Western Chicken Turtle (Deirochelys reticularia miaria; WCT) is a Species of Greatest Conservation Need that is currently under review for federal listing and is assumed to be rare and declining across its range. WCT are threatened by a variety of anthropogenic challenges, including habitat loss, habitat modification, and road mortality. The conservation of this species is further hindered by a lack of understanding of its distribution, abundance, and population trends. These knowledge gaps arise largely from the species’ unique characteristics and cryptic nature. More specifically, WCT demonstrate prolonged aestivation and are notoriously difficult to capture. Environmental DNA …

Cellular And Molecular Mechanism Of Heavy Metal Phytoremediation, Kaitlin A. Edwards, Kayle Dacus, Autumn Wilbanks, Tatum Simms

ATU Scholars Symposium

Rapid urbanization and industrial activities have contributed to heavy metal contamination of several habitats thus leading to an emerging health and environmental challenge. Some heavy metals such as zinc, iron, molybdenum, manganese, copper, cobalt and nickel are found in trace amounts in biological organisms, however, most are harmful for cellular metabolism. Certain species of plants can accumulate large amounts of heavy metals and has been utilized to sustainably clean contaminated soil and water by a process called phytoremediation. Recent lab and field studies have reported promising results that could propel commercialization of this technology. The cellular and molecular mechanism involved …

Cloning The Yersinia Enterocolitica Alkaline Phosphatase For An Affinity Chromatography Ligand, Flavio E. Arellano

ATU Scholars Symposium

Alkaline phosphatase (ALP) is an enzyme responsible for the dephosphorylation of extra-cytoplasmic molecules. Conversion to a neutral molecule enhances their ability to pass through cell membranes. When microbes such as Yersinia enterocolitica are ingested, they are exposed to large changes in pH level. These changes range from ~pH6.5 in the oral cavity to pH 2 in the stomach and pH 8 in the mid-intestine. The ability of microorganisms to survive this change in pH it largely dependent on their ability to change which proteins are expressed at differing pH levels or their ability to modify those proteins to meet the …

Della Protein And Cbl-Cipk Signaling Pathway As Candidates For Genetic Engineering, Nathan F. Surles

ATU Scholars Symposium

No abstract provided.

Detecting Ideological Bias In Trump's Tweets: Trump's Peace Plan As A Case Study, Amer Qasem Dr

Middle East Journal of Communication Studies

This study aims to explore the extent of ideological bias in the discourse of elected U.S. President Donald Trump on social media platforms, specifically Twitter (now known as X), regarding his peace plan, commonly referred to as the "Deal of the Century." The study employs Critical Discourse Analysis (CDA) to examine all of Trump’s tweets related to the Deal of the Century, seeking to answer the following research questions: How did Trump portray the parties affected by the deal in his tweets? What rhetorical strategies did he employ to present the deal? The analysis spans the period from the announcement …

The Use Of Artificial Intelligence Applications By Media Students In Palestinian Universities And Their Achieved Gratifications “A Field Study”, Said Shaheen Allani Dr, Ahmad Al Sallaq

Middle East Journal of Communication Studies

The study aimed to identify the extent to which media students in Palestinian universities use artificial intelligence applications and the achieved gratifications from it. The study belongs to the descriptive studies approach utilizing questionnaire as a tool for collecting data, for an available sample of (165) individuals that were distributed in five Palestinian universities. The study reached to; (54.5%) of media students in Palestinian universities use artificial intelligence applications, they use it for several reasons, the most important phrase is “it helps me to produce good digital content,” with a relative weight of (47.4%), it also achieves a number of …

Media Frameworks In Addressing Environmental Issues On Al Jazeera Net Website: An Analytical Study, Sabah Al Harahsheh Dr

Middle East Journal of Communication Studies

This study aimed to recognize the media frameworks used to address environmental issues on (Al Jazeera Net) between 2009 and 2024. The study relied on the descriptive survey method, the theory of media frames, and the content analysis as a method and tool. The study population consisted of all articles, reports and interviews published on the (Al Jazeera Net) throughout the period specified by the study. A purposive sample was selected from the articles, reports and interviews interested in environmental issues only, which numbered eighteen journalistic works. The study identified the most important frameworks that presented the environmental issues during …

The Mediating Role Of Remote Communication On The Relationship Between Electronic Human Resource Management Practices And Organizational Performance In Iraqi Commercial Banks, Shuhub Basel Ahmad Taqa

Middle East Journal of Communication Studies

This study aimed to measure the impact of remote communication as a mediating variable on the relationship between electronic human resources (e-HRM) and organizational performance in Iraqi commercial banks. The study adopted a descriptive-analytical approach, with the study population consisting of managers, their deputies, and department heads in Iraqi commercial banks, totaling 242 individuals distributed across 24 commercial banks by the end of 2023. A total of 234 questionnaires were analyzed, achieving a response rate of 96.7%. The study employed Smart PLS software for data analysis and result extraction. The study revealed several key findings, the most significant of which …

Neuroarts And Neuroaesthetics, James Hutson, Piper Hutson

Faculty Scholarship

Recent advancements in neuroarts and neuroaesthetics have elucidated the relationship between artistic engagement and neural processes, emphasizing the impact of aesthetic experiences on cognitive and emotional well-being. Central to this exploration is the NeuroArts Blueprint initiative, which consolidates interdisciplinary research to better understand the impactful role of the arts on brain function and health outcomes. Empirical studies highlight how exposure to art, such as music or visual stimuli, activates neural circuits involved in emotion regulation, memory, and reward processing, particularly engaging the medial orbitofrontal cortex. Innovations such as haptic and electro-tactile devices have introduced novel sensory modalities that not only …

Glycosylation Of Serine/Threonine-Rich Intrinsically Disordered Regions Of Membrane-Associated Proteins In Streptococci., Mohammad M Rahman, Svetlana Zamakhaeva, Jeffrey S. Rush, Catherine T Chaton, Cameron W Kenner, Yin Mon Hla, Ho-Ching Tiffany Tsui, Vladimir N Uversky, Malcolm E Winkler, Konstantin V Korotkov, Natalia Korotkova

Molecular and Cellular Biochemistry Faculty Publications

Proteins harboring intrinsically disordered regions (IDRs) lacking stable secondary or tertiary structures are abundant across the three domains of life. These regions have not been systematically studied in prokaryotes. Here, our genome-wide analysis identifies extracytoplasmic serine/threonine-rich IDRs in several biologically important membrane-associated proteins in streptococci. We demonstrate that these IDRs are glycosylated with glucose by glycosyltransferases GtrB and PgtC2 in Streptococcus pyogenes and Streptococcus pneumoniae, and with N-acetylgalactosamine by a Pgf-dependent mechanism in Streptococcus mutans. The absence of glycosylation leads to a defect in biofilm formation under ethanol-stressed conditions in S. mutans. We link this phenotype to the C-terminal IDR …

Enhanced And Interpretable Prediction Of Multiple Cancer Types Using A Stacking Ensemble Approach With Shap Analysis, Shahid Mohammad Ganie, Pijush Kanti Dutta Pramanik, Zhongming Zhao

Faculty, Staff and Student Publications

Background: Cancer is a leading cause of death worldwide, and its early detection is crucial for improving patient outcomes. This study aimed to develop and evaluate ensemble learning models, specifically stacking, for the accurate prediction of lung, breast, and cervical cancers using lifestyle and clinical data.

Methods: 12 base learners were trained on datasets for lung, breast, and cervical cancer. Stacking ensemble models were then developed using these base learners. The models were evaluated for accuracy, precision, recall, F1-score, AUC-ROC, MCC, and kappa. An explainable AI technique, SHAP, was used to interpret model predictions.

Results: The stacking …

Bridging Social And Ecological Science To Create Spatially Explicit Models Of Human-Caused Mortality Of Carnivores, Jeremy T. Bruskotter, Neil H. Carter, Richard Berl, Joseph Hinton, Jazmin Murphy, L Mark Elbroch, John A. Vucetich

Michigan Tech Publications

Research indicates that human-caused mortality (HCM) is a key factor limiting numerous large carnivore populations. However, efforts to represent HCM in spatially explicit models have generally been limited in scope-often relying on proxies, such as road or human density. Yet such efforts fail to distinguish different sources of HCM, which can arise from different antecedent processes. We offer a systems-based conceptual framework for understanding the antecedents of HCMs that is grounded in theory from the social and behavioral sciences. Specifically, we first explain how HCMs are usefully distinguished into four types (e.g., accidental, harvest, illicit, control actions), then discuss how …

The Effect Of Cellular Glucose Levels On Inotersen-Mediated Target Reduction In In Vitro Cell Models, Andrea Durwin

Honors Scholar Theses

Antisense oligonucleotide (ASO) drugs are a new therapeutic modality to treat rare as well as common diseases. These drugs work to reduce disease by targeting the mRNA of the gene that causes the disease, therefore limiting the proteins that further propagate the signs and symptoms of the disorder. Many people who suffer from more severe diseases, such as Alzheimer’s, Parkinson’s, Duchenne Muscular Dystrophy (DMD), and a wide array of cancers, utilize ASO drugs for treatment, but the drug is also used with those suffering from more common diseases such as diabetes. The efficacy of ASO drugs to silence their mRNA …

Bacterial Microbiomes In Different Depths Of Sand At The Mississippi Gulf Coast, Hays S. Roth

Honors Theses

Microbial communities in sand play essential roles in their ecosystems, yet little is known about how bacterial diversity and function vary across different sand depths. This study investigated bacterial microbiomes at varying depths (0, 10, 20, 30, and 40 cm) on Biloxi East Beach, on the Mississippi Gulf Coast, using 16S rRNA gene sequencing and assays of extracellular enzyme activity. 11,161 amplicon sequence variants (ASVs) were identified across all samples, with the most abundant bacterial phyla being Planctomycetota, Gammaproteobacteria, and Bacteroidota. Depth had a significant impact on bacterial community composition, with surface layers having more diverse bacterial communities. Microbial diversity …

Comparing Parasitism And Resistance To Flow In Two Populations Of Elimia Virginica, Morgan G. Hicok, Abbie Tomba, Kate Green

Departmental Honors & Graduate Capstone Projects

Snails are important in freshwater ecosystems as primary consumers and are good indicators of the stability of a habitat. Trematodes are parasitic flatworms that infect freshwater snails and can cause changes in metabolic function and growth. Flow rates and water levels are now more variable due to climate change, increasing stress and dislodgment in the snail population. This study investigates how parasites, shell morphology, and native flow environment influence resistance to disturbance. Elimia populations were sampled for differences in parasitism, shell morphology, and ability to withstand high flow environments in two different rivers. Sample sites at the Potomac River were …

Lung Cancer Risk Prediction In Patients With Persistent Pulmonary Nodules Using The Brock Model And Sybil Model, Hui Li, Morteza Salehjahromi, Myrna C B Godoy, Kang Qin, Courtney M Plummer, Zheng Zhang, Lingzhi Hong, Simon Heeke, Xiuning Le, Natalie Vokes, Bingnan Zhang, Haniel A Araujo, Mehmet Altan, Carol C Wu, Mara B Antonoff, Edwin J Ostrin, Don L Gibbons, John V Heymach, J Jack Lee, David E Gerber, Jia Wu, Jianjun Zhang

Faculty, Staff and Student Publications

Background/objectives: Persistent pulmonary nodules are at higher risk of developing into lung cancers. Assessing their future cancer risk is essential for successful interception. We evaluated the performance of two risk prediction models for persistent nodules in hospital-based cohorts: the Brock model, based on clinical and radiological characteristics, and the Sybil model, a novel deep learning model for lung cancer risk prediction.

Methods: Patients with persistent pulmonary nodules-defined as nodules detected on at least two computed tomography (CT) scans, three months apart, without evidence of shrinkage-were included in the retrospective (n = 130) and prospective (n = 301) cohorts. …

Assessing The Effects Of Antibody Glycosylation And Conjugation On Fc-Mediated Effector Functions, Lina Wu

Undergraduate Honors Theses

Increasing research has been conducted on antibody drug conjugates (ADCs) for their oncology applications and potential as treatments for immunological diseases. ADCs usually covalently bind a cytotoxic drug (payload) via a linker to a monoclonal antibody, which targets specific antigens expressed on tumors, delivering the drug directly to cancer cells while minimizing off-target effects. In addition to binding antigens on tumor cells, antibodies also interact with immune cells to activate “effector functions”. This activation is largely driven by the binding of Fcγ-receptors (FcγR) to the Fc region of IgG, which connects the humoral immune responses and cell-mediated immune responses. Antibody …

Mcf-7 Dense Breast Cancer Cells Modulate Stress Through Senescence, Lara Donadio, Moses Alfonso, Josiah Philip, Tyler Zatarain

Molloy Multidisciplinary Undergraduate Research Conference

Breast cancer remains a leading cause of cancer-related mortality among women worldwide, with dense breast tissue being recognized as a significant risk factor for its development. This dense breast tissue, characterized by a higher concentration of mammary glandular tissue, represents additional sites for tumor development. The following study explores how the MCF-7 immortal cell line, representing dense breast cancer, modulates stress responses through cellular senescence. Cellular senescence is a defense mechanism that halts the cell cycle and acts as a tumor suppression mechanism, preventing out-of-control cell proliferation triggered by cytological stress. To simulate these stress conditions, we applied two agents: …

Factors That Contribute To An Increased Risk For Dental Caries And Prevention Methods, Allen Lee

BIO4960: Practicum in Biology I

This health literacy project focuses on identifying effective strategies for preventing dental caries by analyzing various aspects of an individual’s daily habits. Key lifestyle factors such as sleep patterns, dietary choices, and physical activity were explored in relation to their impact on oral health. The motivation for this project arose from direct observations of the high prevalence of cavities during clinical shadowing experiences, as well as growing evidence in the literature, highlighting an increasing trend in dental caries. Dental caries represent significant public health concern, as untreated caries can lead to serious complications such as tooth abscesses and extractions. Despite …

Enhancing Skin Cancer Literacy Amongst Young Adults: A Digital Design, Katherine Stoll

Honors Projects

The skin plays a vital role in protection, regulation, and homeostasis of the human body. Skin cancer, despite being mostly preventable, is one of the most common cancers. Young adults, ages 18 to 25, are vulnerable targets due to risky behaviors and misinformation regarding skin cancer. This project was designed by using digital media and website design to enhance skin cancer health literacy among young adults. Using a systematic literature review and research methods, an interactive website was designed to improve skin cancer health literacy and eliminate common misconceptions. The topics addressed throughout the website were the biological factors of …

Beyond The Label: Unveiling Greenwashing Impacts On Consumer Purchasing In Sunscreen Packaging, Kailee Ransom

Honors Projects

The purpose of this research project is to unveil how the use of greenwashing tactics in marketing can influence a consumer’s actions and purchasing behavior in regard to sunscreen product packaging. It aims to uncover whether environmentally charged language or imagery (or both) on a product has an impact on a consumer’s willingness to purchase the product and their perceptions of the product’s health for their body and the environment. Additionally, are certain demographic profiles - considering a consumer’s age, income level or education level - more inclined to have a positive perception of “environmentally-friendly” sunscreen products?

To answer these …

Quantifying And Characterizing Microplastics In The Greater Philadelphia Region, Emily Lybashev

Biology Honors Papers

Plastic is one of the world's most useful and versatile materials, so it is no wonder that 400 million tons are produced yearly. When exposed to weathering, heat, water, and organisms, plastic degrades and produces microplastics. These microplastics have managed to leach into our oceans, local waterways, bodies, and even our atmosphere. The negative implications of microplastic contamination in our environment are slowly being uncovered with concerns of toxin buildup. Additionally, the amount of microplastics we are exposed to through local waterways is rarely quantified. Though microplastic research is picking up pace, the Schuylkill River which spans the Greater Philadelphia …

The Role And Expression Of Pros-1 In The C. Elegans Gonad, Brandon W. Thomas, Mary B. Kroetz, Roberta Challener

Undergraduate Theses

The nematode, formally known as Caenorhabditis elegans, has served as an excellent model organism in understanding fundamental biological processes, including those governed by conserved genes like pros-1. pros-1 is partially responsible for the formation of tubular structures within the organism. Glial cells and excretory canals are both examples of tubular structures governed by pros-1. pros-1 orchestrates the embryonic development of these cell types by modulating cell proliferation and differentiation, thus ensuring proper morphogenesis and organogenesis. Its regulatory influence likely extends beyond embryogenesis, potentially affecting reproductive processes as well. Furthermore, the evolutionary conservation of pros-1 underscores its significance …