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Articles 119371 - 119400 of 255935

Full-Text Articles in Life Sciences

Optimization On Extraction Of Capsaicinoids Assisted By Ultrasonic-Microwave Synergistic Extracting, Pang Min, Wang Yuanhui, Liu Qian Dec 2016

Optimization On Extraction Of Capsaicinoids Assisted By Ultrasonic-Microwave Synergistic Extracting, Pang Min, Wang Yuanhui, Liu Qian

Food and Machinery

Paprikas were soaked in 90% (V/V) ethanol to extract capsaicinoids by using ultrasonic and microwave assisted extraction (UMAE). Based on the results of single factor experiments, the optimized extraction condition were gotten with orthogonal tests: the ultrasonic power of 50 W, the microwave power of 240 W, the solid- solvent ratio of 1∶20 (g/mL), the microwave time of 480 s, the paprikas particle size of 80 mesh, and the extracting time twice. The present study obtained an extraction rate of 84.52%. Compared with the conventional water bath extraction method, UMAE has the advantages of shorter extraction time and higher efficiency, …

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Study On Quality Improving In Flavor Of Finished Summer Green Tea By Dry-Heat Post-Treatment, Li Yan, He Chunlei, Meng Xueli, Pei Xujing, Nie Congning, Li Tao Dec 2016

Study On Quality Improving In Flavor Of Finished Summer Green Tea By Dry-Heat Post-Treatment, Li Yan, He Chunlei, Meng Xueli, Pei Xujing, Nie Congning, Li Tao

Food and Machinery

Taking the finished summer green tea as the raw material, the single factor and orthogonal experiment were conducted by using dry-heat post-treatment to study the optimum technological parameter and effect of the optimum technical on the flavor of summer green tea. The results showed that: dry-heat post-treatment had a significant effect on improving the flavor quality of summer green tea. The optimum technicals were as followed: temperature 55 ℃, water content of unprocessed tea 9% and time 6 h. Sensory of the processed summer green tea showed aging taste disappeared, bitterness decreased and become mellow. In taste composition, the content …

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Preparation And Characterization Of The Powder Microcapsules Of Cashew Nut, Chen Sida, Liang Lu, Li Yuting, Yan Xiaoyan, Liu Chengmei, Zhong Yejun, Zhong Junzhen, Xiong Yang Dec 2016

Preparation And Characterization Of The Powder Microcapsules Of Cashew Nut, Chen Sida, Liang Lu, Li Yuting, Yan Xiaoyan, Liu Chengmei, Zhong Yejun, Zhong Junzhen, Xiong Yang

Food and Machinery

Cashew was used to explore its powder microcapsule, and the production methods were optimized as well as its properties and structures represented. The results showed that the emulsion stability was the best, when emulsifier ratio of single and double fat gump to sucrose ester was 1∶2. Moreover, the best emulsifier content was found to be 1.5%, and the best core wall proportion was 1∶1, with the best solid content of 25%. Basic ingredients of microcapsules consisted of proteins ( 12.94%), water (2.38%), carbohydrate （61.57%）, ash （2.45%）， and fat (20.66%). Consequently, the rate of mcrocapsule embedding rate 94.10%, with density 0.68 …

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Research Progress On Transport Vibration Damage And Effects Of Fruits On Its Postharvest Physiology Characteristics And Quality, Jiang Bao Dec 2016

Research Progress On Transport Vibration Damage And Effects Of Fruits On Its Postharvest Physiology Characteristics And Quality, Jiang Bao

Food and Machinery

In our country, truck transport vibration is the important reason which leads to mechanical damage and quality decreased of fruits during storage and transportation. This paper was on the basis of the analysis of the vehicle vibration in the process of truck transportation, and influencing factors, focused on the latest process in effects of transport vibration on postharvest physiology properties and quality of fruits, providing a basis and reference for the reduced transport vibration damage of fruits.

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Research Status And Progress Of Fatty Acid Analysis Methods In Beans, Xie Yanhua, Xie Jing, Li Pao, Chen Miaofen, Jiang Liwen, Chen Lili Dec 2016

Research Status And Progress Of Fatty Acid Analysis Methods In Beans, Xie Yanhua, Xie Jing, Li Pao, Chen Miaofen, Jiang Liwen, Chen Lili

Food and Machinery

In this paper, the methods of fatty acid extraction and methyl esterification of beans (the main products are soy food) were reviewed. A variety of physiological functions of fatty acids are described. Moreover the differences of diverse detection methods of fatty acids were analyzed. We hope to provide testing methods for the change of fatty acids in bean product processing, and providing the basis for the development of potential function's in oil and fat products.

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Research Progress On Physiological Activities And Its Mechanismof Beta-Cryptoxanthin, Sheng Ran, Sun Zhigao, Huang Qiaojuan, Hao Jingmei, Fang Ming, Yu Fengsheng Dec 2016

Research Progress On Physiological Activities And Its Mechanismof Beta-Cryptoxanthin, Sheng Ran, Sun Zhigao, Huang Qiaojuan, Hao Jingmei, Fang Ming, Yu Fengsheng

Food and Machinery

The beta-cryptoxanthin is composed of multiple prenyl units, belonging to the oxidation of carotenoid. It widely exists in persimmon, citrus and other plants, and also can be produced by microbial fermentation..Based on beta-cryptoxanthin, the mechanism of its absorption and physiological activities was reviewed, in order to provide reference for improving research and clinic application of beta-cryptoxanthin.

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Research Of Volatile Components Of Lanzhou Fat-Tailed Sheep, Li Zhenzi, Yang Jutian, Qi Gaozhan, Zang Rongxin, Liu Hongna, Long Ling, Cao Xin Dec 2016

Research Of Volatile Components Of Lanzhou Fat-Tailed Sheep, Li Zhenzi, Yang Jutian, Qi Gaozhan, Zang Rongxin, Liu Hongna, Long Ling, Cao Xin

Food and Machinery

It was aimed to analyze the volatile components and key volatile components of Lanzhou fat-tailed sheep in different gender in this study, and the small fat-tail sheep were chosen as control. The results showed that Lanzhou fat-tailed wethers contained totally 80 kinds of volatile materials, while ewes had 85 kinds. Aldehydes were found the key volatile components, and the relative contents were respectively 31.110% and 22.305%. The key volatile components contained decanal, octanal, nonanal, 2, 4-nonadienal, 2-nonenal, 2,4-decadienal and (E)-2-decenal, which smelled like wax, fat, mushroom and cucumber, and wethers contained 2 more kinds aldehydes than ewes. Compared to small …

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2016, Sep. 22 -- Bulletin 118, Interim Update 2016, California's Groundwater Working Toward Sustainability, Dwr Dec 2016

2016, Sep. 22 -- Bulletin 118, Interim Update 2016, California's Groundwater Working Toward Sustainability, Dwr

State and Federal Documents Relating to Monterey and San Luis Obispo Counties

The purpose of the interim update to Bulletin 118 is to provide up-to-date information on California groundwater basins subject to critical conditions of overdraft, groundwater basin boundaries, and basin prioritization. The information is essential to the successful implementation of the Sustainable Groundwater Management Act passed in 2014 (SGMA), including the timely formation of groundwater sustainability agencies and the development of groundwater sustainability plans.

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Novel Models Of Visual Topographic Map Alignment In The Superior Colliculus., Ruben A Tikidji-Hamburyan, Tarek A El-Ghazawi, Jason W. Triplett Dec 2016

Novel Models Of Visual Topographic Map Alignment In The Superior Colliculus., Ruben A Tikidji-Hamburyan, Tarek A El-Ghazawi, Jason W. Triplett

Pediatrics Faculty Publications

The establishment of precise neuronal connectivity during development is critical for sensing the external environment and informing appropriate behavioral responses. In the visual system, many connections are organized topographically, which preserves the spatial order of the visual scene. The superior colliculus (SC) is a midbrain nucleus that integrates visual inputs from the retina and primary visual cortex (V1) to regulate goal-directed eye movements. In the SC, topographically organized inputs from the retina and V1 must be aligned to facilitate integration. Previously, we showed that retinal input instructs the alignment of V1 inputs in the SC in a manner dependent on …

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U.S. Drought Monitor, December 27, 2016, Brad Rippey Dec 2016

U.S. Drought Monitor, December 27, 2016, Brad Rippey

United States Agricultural Commodities in Drought Archive

Drought map of U.S. for December 27, 2016 (12/27/16) plus: U.S. crop areas experiencing drought (map), Approximate percentage of crop located in drought, by state (bar graph), Percent of crop area located in drought, past 52 weeks (line graph) for: Corn, Soybeans, Hay, Cattle, Winter wheat.

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Macroinvertebrate Community Composition, Food Web Structure, And Emergence Rate In Neotropical Cloud-Forest Streams In Mindo, Ecuador, Anna M. Harris Dec 2016

Macroinvertebrate Community Composition, Food Web Structure, And Emergence Rate In Neotropical Cloud-Forest Streams In Mindo, Ecuador, Anna M. Harris

Masters Theses

Tropical cloud forest streams are one of the most threatened and understudied ecosystems in the world. Understanding how these ecosystems function is essential for effective conservation. In this study, macroinvertebrate community composition, functional feeding group analysis, ecosystem attributes, and physicochemical parameters were used to evaluate biophysical stream conditions of 3 low-order Neotropical cloud forest streams at Reserva Las Gralarias in Mindo, Ecuador. Additionally, food web structure was analyzed via stable isotope analysis and aquatic insect emergence rate was also examined. As stream size increased from 1st to 3rd order, the macroinvertebrate communities shifted from being collector-gatherer dominated (65.2 to 29.8%, …

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Can Sub-Saharan Africa Feed Itself?, Martin K. Van Ittersum, Lenny G. J. Van Bussel, Joost Wolf, Patricio Grassini, Justin Van Wart, Nicolas Guilpart, Lieven Claessens, Hugo De Groot, Keith Wiebe, Daniel Mason-D'Croz, Haishun Yang, Hendrik Boogard, Pepijn A. J. Van Oort, Marloes P. Van Loon, Kazuki Saito, Ochieng Adimo, Samuel Adjei-Nsiah, Alhassane Agali, Abdullahi Bala, Regis Chikowo, Kayuki Kaizzi, Mamoutou Kouressy, Joachim H. J. R. Makoi, Korodjouma Ouattara, Kindie Tesfaye, Kenneth G. Cassman Dec 2016

Can Sub-Saharan Africa Feed Itself?, Martin K. Van Ittersum, Lenny G. J. Van Bussel, Joost Wolf, Patricio Grassini, Justin Van Wart, Nicolas Guilpart, Lieven Claessens, Hugo De Groot, Keith Wiebe, Daniel Mason-D'Croz, Haishun Yang, Hendrik Boogard, Pepijn A. J. Van Oort, Marloes P. Van Loon, Kazuki Saito, Ochieng Adimo, Samuel Adjei-Nsiah, Alhassane Agali, Abdullahi Bala, Regis Chikowo, Kayuki Kaizzi, Mamoutou Kouressy, Joachim H. J. R. Makoi, Korodjouma Ouattara, Kindie Tesfaye, Kenneth G. Cassman

Department of Agronomy and Horticulture: Faculty Publications

Although global food demand is expected to increase 60% by 2050 compared with 2005/2007, the rise will be much greater in sub- Saharan Africa (SSA). Indeed, SSA is the region at greatest food security risk because by 2050 its population will increase 2.5-fold and demand for cereals approximately triple, whereas current levels of cereal consumption already depend on substantial imports. At issue is whether SSA can meet this vast increase in cereal demand without greater reliance on cereal imports or major expansion of agricultural area and associated biodiversity loss and greenhouse gas emissions. Recent studies indicate that the global increase …

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Generation Of Germ-Free /Ciona Intestinalis For Studies Of Gut-Microbe Interactions, Brittany A Leigh, Assunta Liberti, Larry J Dishaw Dec 2016

Generation Of Germ-Free /Ciona Intestinalis For Studies Of Gut-Microbe Interactions, Brittany A Leigh, Assunta Liberti, Larry J Dishaw

Marine Science Faculty Publications

Microbes associate with animal hosts, often providing shelter in a nutrient-rich environment. The gut, however, can be a harsh environment with members of the microbiome settling in distinct niches resulting in more stable, adherent biofilms. These diverse communities can provide orders of magnitude more gene products than the host genome; selection and maintenance of a functionally relevant and useful microbiome is now recognized to be an essential component of homeostasis. Germ-free (GF) model systems allow dissection of host-microbe interactions in a simple and direct way where each member of the symbiosis can be studied in isolation. In addition, because immune …

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Reef Society And The Tyranny Of Data, Robert Wintner Dec 2016

Reef Society And The Tyranny Of Data, Robert Wintner

Animal Sentience

Modern science now approaches divergent processes in many areas, including health assessments of marine eco-systems and social aspects of marine species. Scientific data have long enjoyed a reputation for objectivity but incidents of science-for-hire, data spinning/skewing and political jading are more frequent than ever. In the field of reef creature sensitivity, technical treatises can “logically” explain away what a person of average education can clearly observe on any given reef. Western medicine discounted anecdotal evidence of any cure outside the 4% margin of error until those cures demanded attention and in some cases application. Modern science must now enter an …

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Still Wondering How Flesh Can Feel, Gwen J. Broude Dec 2016

Still Wondering How Flesh Can Feel, Gwen J. Broude

Animal Sentience

Reber believes he has simplified Chalmers’s “hard problem” of consciousness by arguing that subjectivity is an inherent feature of biological forms. His argument rests on the related notions of continuity of mind and gradual accretion of capacities across evolutionary time. These notions need to be defended, not just asserted. Because Reber minimizes the differences in mental faculties among species across evolutionary time, it becomes easier to assert, and perhaps believe, that sentience is already present in early biological forms. The more explicit we are about the differences among these mental faculties and the differences across species, the less persuasive is …

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Population Density, Habitat Dynamic And Aerial Survival Of Relict Cave Bivalves From Genus Congeria In The Dinaric Karst, Olga Jovanović Glavaš, Branko Jalžić, Helena Bilandžija Dec 2016

Population Density, Habitat Dynamic And Aerial Survival Of Relict Cave Bivalves From Genus Congeria In The Dinaric Karst, Olga Jovanović Glavaš, Branko Jalžić, Helena Bilandžija

International Journal of Speleology

Caves are some of the least-known ecosystems on Earth and long-term ecological studies and population size estimates are very rare. Genus Congeria is a Tertiary relict that comprises three species from Dinaric karst area; C. kusceri, C. jalzici and C. mulaomerovici, each with very limited distribution. They are the only known cave bivalves and in contrast to many other cave species, they form populations with high densities. We estimated that the population of C. kusceri in Jama u Predolcu is between 72,454 and 72,906 individuals. The highest density occurred between one and three meters depth, and reached maximum …

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Ric-8a, A G Protein Chaperone With Nucleotide Exchange Activity Induces Long-Range Secondary Structure Changes In Gα, Ravi Kant, Baisen Zeng, Celestine J. Thomas, Brian Bothner, Stephen R. Sprang Dec 2016

Ric-8a, A G Protein Chaperone With Nucleotide Exchange Activity Induces Long-Range Secondary Structure Changes In Gα, Ravi Kant, Baisen Zeng, Celestine J. Thomas, Brian Bothner, Stephen R. Sprang

Biological Sciences Faculty Publications

Cytosolic Ric-8A has guanine nucleotide exchange factor (GEF) activity and is a chaperone for several classes of heterotrimeric G protein α subunits in vertebrates. Using Hydrogen-Deuterium Exchange-Mass Spectrometry (HDX-MS) we show that Ric-8A disrupts the secondary structure of the Gα Ras-like domain that girds the guanine nucleotide-binding site, and destabilizes the interface between the Gαi1 Ras and helical domains, allowing domain separation and nucleotide release. These changes are largely reversed upon binding GTP and dissociation of Ric-8A. HDX-MS identifies a potential Gα interaction site in Ric-8A. Alanine scanning reveals residues crucial for GEF activity within that sequence. HDX confirms that, …

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Microbial Phytases And Phytate: Exploring Opportunities For Sustainable Phosphorus Management In Agriculture, Nelly P. Balaban, Aliya D. Suleimanova, Lia R. Valeeva, Inna B. Chastukhina, Natalia L. Rudakova, Margarita R. Sharipova, Eugene V. Shakirov Dec 2016

Microbial Phytases And Phytate: Exploring Opportunities For Sustainable Phosphorus Management In Agriculture, Nelly P. Balaban, Aliya D. Suleimanova, Lia R. Valeeva, Inna B. Chastukhina, Natalia L. Rudakova, Margarita R. Sharipova, Eugene V. Shakirov

Biological Sciences Faculty Research

Myo-inositol phosphates (phytates) are important biological molecules produced largely by plants to store phosphorus. Phytate is very abundant in many different soils making up a large portion of all soil phosphorus. This review assesses current phytase science from the perspective of its substrate, phytate, by examining the intricate relationship between the phytate-hydrolyzing enzymes and phytate as their substrate. Specifically, we examine available data on phytate’s structural features, distribution in nature and functional roles. The role of phytases and their localization in soil and plant tissues are evaluated. We provide a summary of the current biotechnological advances in using industrial …

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Effects Of Transportation Hazards On High Barrier Flexible Packaging Films, Kyle Dunno Dec 2016

Effects Of Transportation Hazards On High Barrier Flexible Packaging Films, Kyle Dunno

Journal of Applied Packaging Research

Two flexible food packaging barrier material film structures were employed for this research study to evaluate the effects of over-the-road truck transport. The films containing different barrier materials, ethylene-vinyl alcohol (EVOH) or aluminum oxide (AlOx), were selected based on their abundant use within the flexible food packaging arena. Pouches were formed and filled with tomato paste before being thermally processed then palletized for shipment. Pouches were shipped over-the-road via truck transport a distance of 2,500 miles. After transport, the oxygen transmission rate (OTR) of the pouches located on the bottom and top layers of the palletized loads were obtained and …

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High Tunnel Tomato Variety Report Uri 2016, Andy Mark Radin Dec 2016

High Tunnel Tomato Variety Report Uri 2016, Andy Mark Radin

University of Rhode Island Vegetable Production Research Reports

No abstract provided.

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Pumpkin Variety Trial Uri 2016, Rebecca Brown Dec 2016

Pumpkin Variety Trial Uri 2016, Rebecca Brown

University of Rhode Island Vegetable Production Research Reports

No abstract provided.

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Butternut Squash Variety Trial Uri 2016, Rebecca Brown Dec 2016

Butternut Squash Variety Trial Uri 2016, Rebecca Brown

University of Rhode Island Vegetable Production Research Reports

No abstract provided.

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Rit1 Gtpase Regulates Sox2 Transcriptional Activity And Hippocampal Neurogenesis, Sajad Mir, Weikang Cai, Douglas A. Andres Dec 2016

Rit1 Gtpase Regulates Sox2 Transcriptional Activity And Hippocampal Neurogenesis, Sajad Mir, Weikang Cai, Douglas A. Andres

Molecular and Cellular Biochemistry Faculty Publications

Adult neurogenesis, the process of generating mature neurons from neuronal progenitor cells, makes critical contributions to neural circuitry and brain function in both healthy and disease states. Neurogenesis is a highly regulated process in which diverse environmental and physiological stimuli are relayed to resident neural stem cell populations to control the transcription of genes involved in self-renewal and differentiation. Understanding the molecular mechanisms governing neurogenesis is necessary for the development of translational strategies to harness this process for neuronal repair. Here we report that the Ras-related GTPase RIT1 serves to control the sequential proliferation and differentiation of adult hippocampal neural …

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Molecular Typing And Virulence Analysis Of Multidrug Resistant Klebsiella Pneumoniae Clinical Isolates Recovered From Egyptian Hospitals, Reham Wasfi, Walid F. Elkhatib, Hossam M. Ashour Dec 2016

Molecular Typing And Virulence Analysis Of Multidrug Resistant Klebsiella Pneumoniae Clinical Isolates Recovered From Egyptian Hospitals, Reham Wasfi, Walid F. Elkhatib, Hossam M. Ashour

Molecular Biosciences Faculty Publications

Klebsiella pneumonia infection rates have increased dramatically. Molecular typing and virulence analysis are powerful tools that can shed light on Klebsiella pneumonia infections. Whereas 77.7% (28/36) of clinical isolates indicated multidrug resistant (MDR) patterns, 50% (18/36) indicated carpabenem resistance. Gene prevalence for the AcrAB efflux pump (82.14%) was more than that of the mdtK efflux pump (32.14%) in the MDR isolates. FimH-1 and mrkD genes were prevalent in wound and blood isolates. FimH-1 gene was prevalent in sputum while mrkD gene was prevalent in urine. Serum resistance associated with outer membrane protein coding gene (traT) was found in all blood …

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Bioremoval Of Phenol From Aqueous Solutions Using Native Caribbean Seaweed, Abel E. Navarro, Anibal Hernandez-Vega, Md Emran Masud, Loretta M. Roberson, Liz M. Diaz-Vázquez Dec 2016

Bioremoval Of Phenol From Aqueous Solutions Using Native Caribbean Seaweed, Abel E. Navarro, Anibal Hernandez-Vega, Md Emran Masud, Loretta M. Roberson, Liz M. Diaz-Vázquez

Publications and Research

Among several Puerto Rican algae, Sargassum sp. (SG) and Chaetomorpha (CM) showed the highest phenol adsorption capacity from aqueous solutions and were used in optimized adsorption batch experiments at room temperature. The effects of pH, adsorbent dose, phenol concentration, salinity and presence of interfering substances were evaluated. Initial solution pH exhibited a strong effect, mainly on the phenol aqueous chemistry; showing the maximum adsorption at pH 10. Sorption isotherm results were modelled according to the Langmuir, Tempkin and Freundlich equations. Isotherm modelling indicated a maximum adsorption capacity (qmax) of 82.10 and 17.7 mg of phenol per gram of SG and …

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Adaptive Variation And Introgression Of A Constans-Like Gene In North American Red Oaks, Jennifer F. Lind-Riehl, Oliver Gailing Dec 2016

Adaptive Variation And Introgression Of A Constans-Like Gene In North American Red Oaks, Jennifer F. Lind-Riehl, Oliver Gailing

Michigan Tech Publications, Part 1

Oaks provide a model system to study maintenance of species identity by divergent selection since they maintain morphological differences and ecological adaptations despite interspecific hybridization. The genome of closely related interfertile oak species was shown to be largely homogeneous, with a few genomic areas exhibiting high interspecific differentiation possibly as result of strong divergent selection. Previously, a genic microsatellite was identified as under strong divergent selection, being nearly fixed on alternative alleles in the two interfertile North American red oak species: Quercus rubra L. and Quercus ellipsoidalis E.J. Hill. Further genotyping in two other red oak species—Quercus velutina Lam. and …

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A Machine Learning Approach For Using The Postmortem Skin Microbiome To Estimate The Postmortem Interval, Hunter R. Johnson, Donovan D. Trinidad, Stephania Guzman, Zenab Khan, James V. Parziale, Jennifer M. Debruyn, Nathan H. Lents Dec 2016

A Machine Learning Approach For Using The Postmortem Skin Microbiome To Estimate The Postmortem Interval, Hunter R. Johnson, Donovan D. Trinidad, Stephania Guzman, Zenab Khan, James V. Parziale, Jennifer M. Debruyn, Nathan H. Lents

Publications and Research

Research on the human microbiome, the microbiota that live in, on, and around the human person, has revolutionized our understanding of the complex interactions between microbial life and human health and disease. The microbiome may also provide a valuable tool in forensic death investigations by helping to reveal the postmortem interval (PMI) of a decedent that is discovered after an unknown amount of time since death. Current methods of estimating PMI for cadavers discovered in uncontrolled, unstudied environments have substantial limitations, some of which may be overcome through the use of microbial indicators. In this project, we sampled the microbiomes …

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The Chemistry Of The Flint Water Crisis, Ernest M. Oleksy Dec 2016

The Chemistry Of The Flint Water Crisis, Ernest M. Oleksy

The Downtown Review: An Interdisciplinary Journal Written and Peer-Reviewed by Mandel Honors College Students at Cleveland State University

Politics and science do not always go hand-in-hand. Nowhere was this more clear than in the Flint Water Crisis. Negligence towards growing levels of lead poisoning in drinking water led to incredibly deleterious effects on Flint's citizens. The chemistry of equilibrium and the shortcomings of local leaders led to Flint's water becoming a crisis.

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Factors Influencing Swallow Bug (O. Vicarius) Populations Within Cliff Swallows Nests, Paul Mcphail Dec 2016

Factors Influencing Swallow Bug (O. Vicarius) Populations Within Cliff Swallows Nests, Paul Mcphail

Ursidae: The Undergraduate Research Journal at the University of Northern Colorado

Hematophagous ectoparasites such as swallow bugs (Oeciacus vicarius) have been shown to have a profound negative impact on infested bird chicks, and one study shows that O. vicarius populations are positively correlated with large colonies. In this study, we investigated the abundance of O. vicarius and other arthropods within Cliff Swallow nests, and performed statistical analysis of the results to find any variables that correlated with O. vicarius population size. We expected the number of O. vicarius would be positively influenced by urban surroundings and large Cliff Swallow colony size, and that samples collected in the fall would be larger …

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Vamorolone, A Dissociative Steroidal Compound, Reduces Pro-Inflammatory Cytokine Expression In Glioma Cells And Increases Activity And Survival In A Murine Model Of Cortical Tumor., Elizabeth Wells, Madhuri Kambhampati, Jesse M Damsker, Heather Gordish-Dressman, Sridevi Yadavilli, Oren J Becher, Jamila Gittens, Mojca Stampar, Roger J. Packer, Javad Nazarian Dec 2016

Vamorolone, A Dissociative Steroidal Compound, Reduces Pro-Inflammatory Cytokine Expression In Glioma Cells And Increases Activity And Survival In A Murine Model Of Cortical Tumor., Elizabeth Wells, Madhuri Kambhampati, Jesse M Damsker, Heather Gordish-Dressman, Sridevi Yadavilli, Oren J Becher, Jamila Gittens, Mojca Stampar, Roger J. Packer, Javad Nazarian

Genomics and Precision Medicine Faculty Publications

Corticosteroids, such as dexamethasone, are routinely used as palliative care in neuro-oncology for their anti-inflammatory benefits, however many patients experience dose limiting side effects caused by glucocorticoid response element (GRE)-mediated transcription. The purpose of this study was to use a murine model to investigate a new steroid alternative, vamorolone, which promises to reduce side effects through dissociating GRE-mediated transcription and NF-κB -mediated anti-inflammatory actions. To compare vamorolone to dexamethasone in reducing pro-inflammatory signals in vitro, murine glioma cells were treated with dexamethasone, vamorolone or vehicle control. Changes in mRNA expression were assessed using the nanostring inflammatory platform. Furthermore, drug …

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