Effect Of Backgrounding Management Strategies On The Performance And Profitability Of Yearling Beef Cattle, Cody Alan Welchons

Department of Animal Science: Dissertations, Theses, and Student Research

Performance and profitability of steers grazing smooth bromegrass during the summer was evaluated. Steers grazed bromegrass with no supplement (CON), grazed bromegrass fertilized with 90 kg N/ha (FERT), or grazed bromegrass and were supplemented with distillers grains plus solubles (DGS) at 0.6% of BW (SUPP). Supplemented steers had increased ADG compared to CON and FERT steers. Profitability was greatest for the SUPP steers due to increased ending BW at the end of the grazing season. Steers grazing fertilized pastures were more profitable than CON steers due to increased stocking rate as a result of improved forage growth.

A 2-yr study …

Optimal Use Of Eeg Recordings To Target Active Brain Areas With Transcranial Electrical Stimulation, Jacek P. Dmochowski

Publications and Research

To demonstrate causal relationships between brain and behavior, investigators would like to guide brain stimulationusing measurements of neural activity. Particularly promising in this context are electroencephalography (EEG) and transcranial electrical stimulation (TES), as they are linked by a reciprocity principle which, despite being known for decades, has not led to a formalism for relating EEG recordings to optimal stimulation parameters. Here we derive a closed-form expression for the TES configuration that optimally stimulates (i.e., targets) the sources of recorded EEG, without making assumptions about source location or distribution. We also derive a duality between TES targeting and EEG source …

Maternal Physical Activity And Cardiorespiratory Fitness During Pregnancy And Its Relation To Infant Size, Samantha M. Mcdonald

Theses and Dissertations

Recent evidence indicates that U.S.-born infants are larger today compared to 20 years ago. A strong determinant of neonatal size is maternal body mass, where larger mothers deliver larger infants. Consistent evidence indicates that higher levels of maternal physical activity (PA) during pregnancy reduce the risk of delivering a larger infant. However, this protective effect has only been demonstrated in normal weight pregnant women. Little is known about the relationship between maternal PA and neonatal size in overweight or obese pregnant women. Moreover, no studies have examined the association between maternal cardiorespiratory fitness (CRF), an indicator of habitual PA, on …

The Effect Of Energy-Matched Exercise Intensity On Brain-Derived Neurotrophic Factor And Motor Learning, Jessica F. Baird

Theses and Dissertations

Brain plasticity is important to motor learning, and is a critical component of motor rehabilitation. Exercise prior to motor training may facilitate plasticity by increasing brain-derived neurotrophic factor (BDNF). However, many studies that have investigated exercise-enhanced plasticity have assessed motor skill performance on tasks involving single finger button presses or small movements of a joystick, results that may not relate to more complex, real-world movements. Additionally, while high-intensity exercise has been shown to benefit motor learning, the effects of low-intensity exercise have yet to be fully investigated. A bout of low-intensity exercise, when completed at an energy expenditure that is …

The Role Of Notch-1-Mediated Repression Of Pten On Growth And Cancer Stem Cell Survival In Trastuzumab Resistant, Her2+ Breast Cancer, Andrew Thomas Baker

Dissertations

Trastuzumab targets the ErbB2 (HER2) receptor on breast cancer cells to attenuate HER2 driven tumor formation. Trastuzumab reduces both downstream PI3K/Akt and MAPK pathway signaling as well as the breast cancer stem cell (BCSC) population. BCSCs are hypothesized to be responsible for tumor recurrence, metastasis, as well as drug resistance. Today, resistance to trastuzumab remains a major clinical problem for women diagnosed with HER2+ breast cancer. Attenuation of PI3K/Akt and MAPK pathways may occur through the tumor suppressor, PTEN. Women with HER2+ breast tumors expressing less PTEN and increased PI3K/Akt or MAPK activity have worse overall outcome. Previously we have …

Cellular Determinants Of Coronavirus Entry Routes, James Thomas Earnest

Dissertations

Coronaviruses (CoVs) represent some of the greatest modern threats to global health. CoVs are zoonotic viruses that generally cause respiratory or enteric infections. The ability of CoVs to move between species and into human populations ensures that CoVs will remain important and dangerous pathogens. Therefore, understanding how CoVs infect different hosts is vital to human health.

CoVs are enveloped and must undergo fusion of viral and host membranes to initiate infection. Viral glycoproteins, called Spike (S) proteins, are responsible for host cell binding and carrying out the membrane fusion reaction. S proteins store energy in their folded, pre-fusion conformation that …

Mutual Regulation Of Crp And N(Epsilon)-Lysine Acetylation In Escherichia Coli, Robert James Davis

Dissertations

Post-translational modifications, such as N(epsilon)-lysine acetylation, are known to alter the behavior of transcriptional regulators in eukaryotes, but very little is known about the consequences of acetylation on transcriptional regulation in bacteria. Here, I provide evidence that a global transcriptional regulator of carbon metabolism, cAMP Receptor Protein (CRP), promotes both enzymatic and non-enzymatic lysine acetylation in E. coli. Non-enzymatic lysine acetylation occurs when cells ferment acetate, such as during growth on high concentrations of glucose. Intriguingly, CRP can be non-enzymatically acetylated on several lysines, including lysine 100 (K100). I provide evidence that neutralization of the K100 positive charge, as would …

A Potential Tool For Clinicians; Evaluating A Computer-Led Dietary Assessment Method In Overweight And Obese Women During Weight Loss, Adrianne Widaman, Nancy Keim, Dustin Burnett, Beverly Miller, Megan Witbracht, Keith Widaman, Kevin Laugero

Faculty Publications

Many Americans are attempting to lose weight with the help of healthcare professionals. Clinicians can improve weight loss results by using technology. Accurate dietary assessment is crucial to effective weight loss. The aim of this study was to validate a computer-led dietary assessment method in overweight/obese women. Known dietary intake was compared to Automated Self-Administered 24-h recall (ASA24) reported intake in women (n = 45), 19–50 years, with body mass index of 27–39.9 kg/m2. Participants received nutrition education and reduced body weight by 4%–10%. Participants completed one unannounced dietary recall and their responses were compared to actual intake. Accuracy of …

The Use Of Informativity In The Development Of Robust Viromics-Based Examinations, Siobhan C. Watkins, Catherine Putonti

Bioinformatics Faculty Publications

Metagenomics-based studies have provided insight into many of the complex microbial communities responsible for maintaining life on this planet. Sequencing efforts often uncover novel genetic content; this is most evident for phage communities, in which upwards of 90% of all sequences exhibit no similarity to any sequence in current data repositories. For the small fraction that can be identified, the top BLAST hit is generally posited as being representative of a viral taxon present in the sample of origin. Homology-based classification, however, can be misleading as sequence repositories capture but a small fraction of phage diversity. Furthermore, lateral gene transfer …

A Review Of Neogene And Quaternary Pikes Of Southeastern Europe And A New Species From The Early Pleistocene Of Nogaisk, Ukraine, Terry C. Grande, Oleksandr M. Kovalchuk, Mark V. H. Wilson

Biology: Faculty Publications and Other Works

The fish genus Esox (Teleostei, Esocidae) has been recorded from thirty late Miocene, Pliocene, and Pleistocene localities where forty-one bone-bearing strata are exposed in the territory of Ukraine, Russian Federation, and Republic of Moldova. From eight localities the genus is reported or described for the first time. A detailed description and morphological analysis of the currently available osteological material demonstrates the presence of four species in the studied area: (i) Esox sibiricus (late Miocene–early Pliocene); (ii) Esox moldavicus (early Pliocene–early Pleistocene); (iii) Esox nogaicus sp. nov. (early Pleistocene, Calabrian); (iv) Esox lucius (early–middle Pleistocene). The Northern Pike (Esox lucius …

Sensitizing Leukemia Stem Cells To Nf-Κb Inhibitor Treatment In Vivo By Inactivation Of Both Tnf And Il-1 Signaling, Peter W. Breslin, Jing Li, Andrew Volk, Jun Zhang, Joseph Cannova, Shaojun Dai, Caiqin Hao, Chenglong Hu, Jiewen Sun, Yan Xu, Wei Wei, Sucha Nand, Jianjun Chen, Ameet Kini, Jiang Zhu, Jiwang Zhang

Biology: Faculty Publications and Other Works

We previously reported that autocrine TNF-α (TNF) is responsible for JNK pathway activation in a subset of acute myeloid leukemia (AML) patient samples, providing a survival/proliferation signaling parallel to NF-κB in AML stem cells (LSCs). In this study, we report that most TNF-expressing AML cells (LCs) also express another pro-inflammatory cytokine, IL1β, which acts in a parallel manner. TNF was produced primarily by LSCs and leukemic progenitors (LPs), whereas IL1β was mainly produced by partially differentiated leukemic blasts (LBs). IL1β also stimulates an NF-κB-independent pro-survival and proliferation signal through activation of the JNK pathway. We determined that co-inhibition of signaling …

Deformation But Not Migration And Rotation – A Model Study On Vesicle Biomechanics In A Uniform Dc Electric Field, Hui Ye, Austen Curcuru

Biology: Faculty Publications and Other Works

Background: Biological cells migrate, deform and rotate in various types of electric fields, which have significant impact on the normal cellular physiology. To investigate electrically-induced deformation, researchers have used artificial giant vesicles that mimic the phospholipid bilayer cell membrane. Containing primarily the neutral molecule phosphatidylcholine, these vesicles deformed under evenly distributed, strong direct current (DC) electric fields. Interestingly, they did not migrate or rotate. A biophysical mechanism underlying the kinematic differences between the biological cells and the vesicles under electric stimulation has not been worked out.

Methods: We modeled the vesicle as a leaky, dielectric sphere and computed …

Vector Competence Of Aedes Sierrensis And Culex Pipiens Complex (Diptera: Culicidae) For Dirofilaria Immitis (Spirurida: Onchocercidae) In Northern California, Jeffrey Allan Kurosaka

University of the Pacific Theses and Dissertations

Dirofilaria immitis Leidy (dog heartworm) is a life-threatening parasite transmitted by mosquitoes to domestic dogs. Endemic in the eastern United States, cases have become more prevalent over the last few decades. While prevalence in California is generally low, Lake and San Joaquin Counties have reported rates comparable to the East Coast at 3.73% and 0.71%(CAPC 2017), respectively. Aedes sierrensis is thought to be responsible for transmission in California, but in some cases, it exists in inadequate quantities and temporal ranges to explain parasite activity. Based on Huang et al. (2013) and Tran (2016), bloodfeeding patterns, and other vector criteria, Culex …

Evolving Academic Culture To Meet Societal Needs, Kateryna Wowk, Larry Mckinney, Frank E. Muller-Karger, Russell Moll, Susan Avery, Elva Escobar-Briones, David Yoskowitz, Richard Mclaughlin

Marine Science Faculty Publications

Given today's complex societal challenges, academia should work better with government, industry and others in offering innovative solutions that benefit our society, economy and environment. Researchers across disciplines must work together and with decision-makers to understand how science can have better on-The-ground impacts toward longer-Term, resilient societal outcomes. This includes, for example, by working with end-users in problem formation and throughout research projects to ensure decision-making needs are being met, and by linking physical science to additional fields like economics, risk communication or psychology. However, persistent barriers to collaborating across disciplines and with external decision-makers remain. Despite decades of studies …

Clinical Consultations And Investigations Before And After Discontinuation Of Endocrine Therapy In Women With Primary Breast Cancer, Derrick Lopez, Anna Kemp-Casey, Christobel Saunders, Elizabeth Roughead, Frances Boyle, Max Bulsara, David Preen

Health Sciences Papers and Journal Articles

Objective: Although clinical trials recommend that women with hormone-dependent primary breast cancer remain on endocrine therapy for at least 5 years, up to 60% discontinue treatment early. We determined whether these women had consulted with clinicians or had investigations for cancer recurrence or metastasis around the time they discontinued endocrine therapy, and whether clinical contact continued after discontinuation.

Methods: We performed case-control and cohort studies of women from the 45 and Up Study who were diagnosed with invasive primary breast cancer between January 2003 and December 2008, and who had ≥12 months of anastrozole, exemestane, letrozole or tamoxifen subsequently dispensed. …

Health Economics Of Targeted Intraoperative Radiotherapy (Targit-Iort) For Early Breast Cancer: A Cost-Effectiveness Analysis In The United Kingdom, Anil Vaidya, Param Vaidya, Brigitte Both, Chris Brew-Graves, Max Bulsara, Jayant S. Vaidya

Health Sciences Papers and Journal Articles

Objective: The clinical effectiveness of targeted intraoperative radiotherapy (TARGIT-IORT) has been confirmed in the randomised TARGIT-A (targeted intraoperative radiotherapy-alone) trial to be similar to a several weeks’ course of whole-breast external-beam radiation therapy (EBRT) in patients with early breast cancer. This study aims to determine the cost effectiveness of TARGIT-IORT to inform policy decisions about its wider implementation. Setting TARGIT-A randomised clinical trial (ISRCTN34086741) which compared TARGIT with traditional EBRT and found similar breast cancer control, particularly when TARGIT was given simultaneously with lumpectomy.

Methods: Cost-utility analysis using decision analytic modelling by a Markov model. A cost-effectiveness Markov model was …

Neuromuscular Training Improves Lower Extremity Biomechanics Associated With Knee Injury During Landing In 11-13 Year Old Female Netball Athletes, A Hopper, E Haff, C Joyce, R Lloyd, G Haff

Health Sciences Papers and Journal Articles

The purpose of this study was to examine the effects of a neuromuscular training (NMT) program on lower-extremity biomechanics in youth female netball athletes. The hypothesis was that significant improvements would be found in landing biomechanics of the lower-extremities, commonly associated with anterior cruciate ligament (ACL) injury, following NMT. Twenty-three athletes (age = 12.2 ± 0.9 years; height = 1.63 ± 0.08m; mass = 51.8 ± 8.5 kg) completed two testing sessions separated by 7-weeks and were randomly assigned to either a experimental or control group. Thirteen athletes underwent 6-weeks of NMT, while the remaining 10 served as controls and …

Tumour-Infiltrating Regulatory T Cell Density Before Neoadjuvant Chemoradiotherapy For Rectal Cancer Does Not Predict Treatment Response, Melanie J. Mccoy, Chris Hemmings, Chidozie C. Anyaegbu, Stephanie J. Austin, Tracey F. Lee-Pullen, Timothy J. Miller, Max K. Bulsara, Nikolajs Zeps, Anna K. Nowak, Richard A. Lake, Cameron F. Platell

Health Sciences Papers and Journal Articles

Neoadjuvant (preoperative) chemoradiotherapy (CRT) decreases the risk of rectal cancer recurrence and reduces tumour volume prior to surgery. However, response to CRT varies considerably between individuals and factors associated with response are poorly understood. Foxp3+ regulatory T cells (Tregs) inhibit anti-tumour immunity and may limit any response to chemotherapy and radiotherapy. We have previously reported that a low density of Tregs in the tumour stroma following neoadjuvant CRT for rectal cancer is associated with improved tumour regression. Here we have examined the association between Treg density in pre-treatment diagnostic biopsy specimens and treatment response, in this same patient cohort. We …

Satellite Observation Of Particulate Organic Carbon Dynamics On The Louisiana Continental Shelf, Chengfeng Le, John C. Lehrter, Chuanmin Hu, Hugh Macintyre, Marcus W. Beck

Marine Science Faculty Publications

Particulate organic carbon (POC) plays an important role in coastal carbon cycling and the formation of hypoxia. Yet, coastal POC dynamics are often poorly understood due to a lack of long-term POC observations and the complexity of coastal hydrodynamic and biogeochemical processes that influence POC sources and sinks. Using field observations and satellite ocean color products, we developed a new multiple regression algorithm to estimate POC on the Louisiana Continental Shelf (LCS) from satellite observations. The algorithm had reliable performance with mean relative error (MRE) of ∼40% and root mean square error (RMSE) of ∼50% for MODIS and SeaWiFS images …

Land Adjacency Effects On Modis Aqua Top-Of-Atmosphere Radiance In The Shortwave Infrared: Statistical Assessment And Correction, Lian Feng, Chuanmin Hu

Marine Science Faculty Publications

Satellite measurements of coastal or inland waters near land/water interfaces suffer from land adjacency effects (LAEs), particularly in the short-wave infrared (SWIR) wavelengths. Here a statistical method was developed to quantify the LAEs as the ratio of top-of-atmosphere (TOA) total radiance (L_t, W m⁻² µm⁻¹ sr⁻¹) between near-shore pixels and LAE-free offshore pixels (>12 pixels away from land). The calculations were conducted using MODIS Aqua images between 2003 and 2012 over the Madagascar Island, with results showing the dependency of LAEs on different environmental and observational factors. The LAEs decrease dramatically with increasing …

Lignocellulosic Syrup Production From Energy Cane Bagasse And Fumaric Acid Fermentation, Fang Deng

LSU Doctoral Dissertations

Lignocellulosic syrup from dilute ammonia pretreated energy cane bagasse is a promising fermentable sugar feedstock that can improve the logistics associated with long-distance transportation, long-time storage, and year-round supply of lignocellulosic biomass to processing industries. However, non-sugar compounds such as organic acids, furans and phenolic compounds formed during pretreatment can have negative effects on downstream processes such as fermentation. This dissertation focused on addressing challenges associated with the bioconversion of energy cane bagasse to syrup and its fermentation to fumaric acid. The first goal (Chapter 2) was to evaluate the removal of non-sugar compounds with minimal sugar losses from dilute …

Termite Gut Microbes As Tools And Targets For Termite Control, Chinmay Vijay Tikhe

LSU Doctoral Dissertations

The Formosan subterranean termite (FST), Coptotermes formosanus, is an invasive urban pest in the United States. Colonies of the FST are dependent on the symbiotic gut protozoa for cellulose digestion in the workers’ guts, and the gut bacterial community is known to provide essential nutrients to the termite. The objectives of this PhD research were to develop and evaluate paratransgenesis and phage therapy for termite control. During this study, a termite gut bacterium: Trabulsiella odontotermitis was genetically engineered and was evaluated as a ‘Trojan horse’ for paratransgenesis. We proved that T. odontotermitis can tolerate 50 times more concentration of ligand-Hecate …

Primate Proteomic Composition Of Seminal Plasma And Prostate-Specific Transglutaminase Activity In Relation To Sexual Selection., Amanda M.C. Zielen

Electronic Theses and Dissertations

Humans (Homo sapiens), chimpanzees (Pan troglodytes), and gorillas (Gorilla gorilla) have diverse mating systems with varying levels of sperm competition. Several seminal plasma genes have been claimed to evolve under positive selection, while others are altered or lost. This study aims to identify biologically relevant differences among seminal plasma proteomes of primates in relation to mating systems and previous genomic studies. Seminal plasma from three individuals of each species were run in triplicate in shotgun liquid chromatography – tandem mass spectrometry (LC-MS/MS) and confirmed with Western blots. Over 7,000 peptides were identified across all …

Modeling The Binding Of Neurotransmitter Transporter Inhibitors With Molecular Dynamics And Free Energy Calculations, Bernandie Jean

Electronic Theses and Dissertations

The monoamine transporter (MAT) proteins responsible for the reuptake of the neurotransmitter substrates, dopamine, serotonin, and norepinephrine, are drug targets for the treatment of psychiatric disorders including depression, anxiety, and attention deficit hyperactivity disorder. Small molecules that inhibit these proteins can serve as useful therapeutic agents. However, some dopamine transporter (DAT) inhibitors, such as cocaine and methamphetamine, are highly addictive and abusable. Efforts have been made to develop small molecules that will inhibit the transporters and elucidate specific binding site interactions. This work provides knowledge of molecular interactions associated with MAT inhibitors by offering an atomistic perspective that can guide …

Physical Health And Physical Self-Concept: A Comparison Of Physical Activity Electives At The Middle School Level, Lisa J. Jennings

Cal Poly Humboldt theses and projects

ABSTRACT

Physical Health and Physical Self-Description: A Comparison of Physical Activity Electives at the Middle School Level

Lisa Jennings

Objective: The purpose of this study was to compare traditional physical education with Zumba to determine which method is the most appropriate and beneficial to the psychological development and well-being of children and adolescents, as well as the ability to increase the activity rates and levels in the United States.

Design: Survey/Questionnaire and Observation Experimental

Methods: Participants included a total of 53 students, currently enrolled in one of two PA elective courses, physical education or Zumba dance class. Participants included students …

Finding Nondestructive Parameters For Root-To-Shoot Ratios In Douglas-Fir, Grand Fir, And Redwood Saplings In Northwest California For Biomass And Carbon Storage Estimates, Walter A. Kast

Cal Poly Humboldt theses and projects

ABSTRACT

FINDING NONDESTRUCTIVE PARAMETERS FOR ROOT-TO-SHOOT RATIOS IN DOUGLAS-FIR, GRAND FIR, AND REDWOOD SAPLINGS IN NORTHWEST CALIFORNIA FOR BIOMASS AND CARBON STORAGE ESTIMATES

Walter A. Kast

There is a need for better understanding of how woody biomass is allocated above and belowground and how this allocation might differ among tree species. In this field of research, investigators face challenges such as the laborious task of removing trees from the soil with destructive sampling, and the cleaning, drying, and weighing of belowground biomass (BGB). Therefore, researchers and practitioners most often rely on existing models to predict BGB from easily-measurable aboveground variables …

The Effects Of Bicycling Exercise On The Metabolic Cost Of Walking In Older Adults, Daniel Hugo Aslan

Cal Poly Humboldt theses and projects

Impaired walking performance is a key determinant of morbidity among older adults. A distinctive characteristic of impaired walking performance among older adults is a greater metabolic cost compared to young adults. Specifically, healthy older adults have been shown to have a 15-20% greater metabolic cost of walking compared to young adults. However, a recent study suggests that older adults who routinely run for exercise have a lower metabolic cost of walking compared to older adults who walk for exercise. Yet, it remains unclear if other aerobic exercises such as bicycling elicits similar improvements on walking metabolic cost among older adults. …

Abundance, Growth, And Predation By Non-Native Brown Trout In The Trinity River, Ca, Justin S. Alvarez

Cal Poly Humboldt theses and projects

Brown Trout were introduced to the Trinity River in Northern California in the 1890’s. Since 1932, Brown Trout have sustained their population without additional stocking. Over the last 15 years, fisheries managers have been concerned that predation by piscivorous Brown Trout may impede efforts to restore native salmonids, in particular endangered Coho Salmon. I investigated predation by Brown Trout on native fish in the 64 km of the main stem Trinity River below Lewiston Dam. Using a bioenergetics approach parameterized with field measurements of Brown Trout abundance and growth, I estimated the amount of energy needed to sustain the 2015 …

Comparison Of Tree Growth And Restoration Treatment Persistence In Riparian And Upland California Montane Forests, Scott D. Burdette

Cal Poly Humboldt theses and projects

This thesis analyzes the growth of red fir (Abies magnifica) and California white fir (Abies concolor var. lowiana) in three different sites in California and creates an individual-tree, distance-independent growth simulator. The first chapter of this thesis is a literature review discussing the issues facing the forests composed of these montane true fir in California and the forest growth simulators in common use. The second chapter uses AICc model comparison to determine which models for each species best predicts growth of individual trees in terms of basal area increment (BAI). The third chapter of this thesis uses these individual-tree growth …

The Bee Fauna Of The Horse Mountain And Grouse Mountain Region, Humboldt County, California, Carrie Lopez

Cal Poly Humboldt theses and projects

Recent concerns about the ecological well-being of bee communities in California and elsewhere have increased the need for monitoring programs and studies that evaluate the impact of habitat loss and alteration on bee diversity and abundance. Such studies depend critically on the expertise of people trained in taxonomy, but their numbers have declined in recent years. My primary goal was to gain a comprehensive first-hand experience with bee identification by documenting the fauna of a previously unstudied area in the mountains of northwestern California and by writing an identification key, intended for dedicated non-specialists, to the area’s 35 species of …