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Articles 116761 - 116790 of 256032
Full-Text Articles in Life Sciences
Effect Of Grazing Pressure On Cattle Grazing Cool Season Annual Forages, Brooke Brunsvig
Effect Of Grazing Pressure On Cattle Grazing Cool Season Annual Forages, Brooke Brunsvig
Electronic Theses and Dissertations
Ruminants can use plant fiber to produce food products that provide nourishment to humans. However, a precise understanding of specific plants selected by grazing ruminants remains elusive. Many long- and short-term factors impact cattle grazing behavior. Ultimately, grazing behavior can affect forage available for grazing, nutrient density of forage, dry matter intake, and animal performance. A myriad of grazing management strategies have been developed utilizing animal behavior to allow more efficient use of forage resources. Many management strategies based on manipulation of grazing behavior are simple and cost effective. Optimal performance of individual animals and amount of animal products produced …
The Cattle Dung Arthropod Community In Eastern South Dakota: Their Colonization, Impact On Degradation, And Response To Rangeland Management, Jacob Pecenka
Electronic Theses and Dissertations
Cattle grazing operations are an important industry throughout the world and a vital component of the economy of the Northern Great Plains. Rangeland management is important to ensure that cattle grazing remains not only profitable but also environmentally sustainable. Conventionally managed rangeland systems that practice continuous grazing and repeated applications of chemicals such as avermectins pose a risk to the continuing productivity of rangelands. These practices have ecological consequences, primarily to the arthropod community that inhabits cattle dung pats. This diverse community works together to recycle dung pats and make the nutrients in dung accessible to the surrounding plant community, …
A Comparison Of Land Use And Land Cover In Public Lands Of The Northwestern Great Plains And High Plains Ecoregions And The Implications For Grassland Birds, Dawn L. Siemonsma
A Comparison Of Land Use And Land Cover In Public Lands Of The Northwestern Great Plains And High Plains Ecoregions And The Implications For Grassland Birds, Dawn L. Siemonsma
Electronic Theses and Dissertations
Loss and degradation of grassland habitat are driving forces that contribute to widespread declines of grassland birds in the United States. Many studies have evaluated habitat needs for the conservation of grassland birds, but the relative contribution of public lands in representing and maintaining avian biodiversity remains poorly understood. Having a better understanding of the role that publicly managed grasslands play in the conservation of grassland bird habitat is important for assessing the value of the investment the American public makes in these lands. Therefore, I investigated spatial relations among variations in amounts and distributions of publicly owned and managed …
Effect Of Pre-Marketing Management Practices On Shrink Loss In Lambs, Ann Kolthoff
Effect Of Pre-Marketing Management Practices On Shrink Loss In Lambs, Ann Kolthoff
Electronic Theses and Dissertations
Two experiments were conducted to evaluate the effects of three common lamb pre-marketing management practices on live weight shrink loss. Additionally a producer survey was conducted to assess current marketing practices in the North Central region of the US. In these experiments, Exp. 1 (feeder lambs) and 2 (finished lambs), 60 commercial Polypay lambs (Exp. 1: 37.65 ± 0.30 kg of BW; Exp. 2: 52.56 ± 0.14 kg of BW) were allocated for each experiment to 3 treatment groups (n=20 lambs) in a 3 x 3 Latin square design. Treatments were the pre-marketing practices: original pen (ORG), transition pen (TRANS), …
Using Gluten Index To Improve Spring Wheat Loaf Volume Prediction, Yaming Lu
Using Gluten Index To Improve Spring Wheat Loaf Volume Prediction, Yaming Lu
Electronic Theses and Dissertations
Wheat (Triticum aestivum L.) is the most widely cultivated crop in the world and contributes about 20% of the total dietary calories and proteins globally. Unique properties of doughs formed from wheat flour make it feasible to produce a range of food, including bread. Loaf volume is the most perceptible indicator for breadmaking quality. Selection in the early generations for loaf volume is difficult due to the requirement of the large volume of grains and due to the costly, time-consuming, and labor-intensive evaluation process. Identification of simple and reliable predictive tests for loaf volume is highly desirable. This study …
The Interactive Effects Of Annual Climatic Variability And Rangeland Management On The Reproductive Success Of Dickcissels (Spiza Americana), Lauren A. Spahr
The Interactive Effects Of Annual Climatic Variability And Rangeland Management On The Reproductive Success Of Dickcissels (Spiza Americana), Lauren A. Spahr
Senior Honors Theses
Grassland songbird populations have declined due to poor rangeland management and habitat fragmentation. Few studies have taken into account variation in climatic conditions in tallgrass prairie systems when determining the factors contributing to songbird reproductive success. During a six year study we measured reproductive success in Dickcissels on five rangeland treatments. We estimated daily survival rates (DSRs) and linked estimates of daily survival to rangeland management type and climate data. DSRs were best predicted by the model including mean temperature, winter season precipitation, and interactions, which had 7.5 times more support than the constant model. Mean annual temperature was negatively …
Comparative Proteomic Analyses Of The Parietal Lobe From Rhesus Monkeys Fed A High-Fat/Sugar Diet With And Without Resveratrol Supplementation, Relative To A Healthy Diet: Insights Into The Roles Of Unhealthy Diets And Resveratrol On Function, Aaron M. Swomley, Judy C. Triplett, Jeriel T. Keeney, Govind Warrier, Kevin J. Pearson, Julie A. Mattison, Rafael De Cabo, Jian Cai, Jon B. Klein, D. Allan Butterfield
Comparative Proteomic Analyses Of The Parietal Lobe From Rhesus Monkeys Fed A High-Fat/Sugar Diet With And Without Resveratrol Supplementation, Relative To A Healthy Diet: Insights Into The Roles Of Unhealthy Diets And Resveratrol On Function, Aaron M. Swomley, Judy C. Triplett, Jeriel T. Keeney, Govind Warrier, Kevin J. Pearson, Julie A. Mattison, Rafael De Cabo, Jian Cai, Jon B. Klein, D. Allan Butterfield
Chemistry Faculty Publications
A diet consisting of a high intake of saturated fat and refined sugars is characteristic of a Western-diet and has been shown to have a substantial negative effect on human health. Expression proteomics were used to investigate changes to the parietal lobe proteome of rhesus monkeys consuming either a high fat and sugar (HFS) diet, a HFS diet supplemented with resveratrol (HFS+RSV), or a healthy control diet for 2 years. Here we discuss the modifications in the levels of 12 specific proteins involved in various cellular systems including metabolism, neurotransmission, structural integrity, and general cellular signaling following a nutritional intervention. …
Vitamin D Status And Bone Mineral Density In Female Collegiate Dancers And Cheerleaders, Tara Sue Kenny, Damon Mccune, Laura J. Kruskall, James Navalta, John C. Young
Vitamin D Status And Bone Mineral Density In Female Collegiate Dancers And Cheerleaders, Tara Sue Kenny, Damon Mccune, Laura J. Kruskall, James Navalta, John C. Young
Kinesiology and Nutrition Sciences Faculty Research
Bone mineral density reflects an athlete’s cumulative history of energy availability, physical activity, and menstrual status, as well as nutritional and environmental factors. Although sports with high-impact loading are associated with higher bone mineral density than low-impact or non-impact sports, confounding variables are differences in the athletes’ body size and sport-specific training. The purpose of this study was to determine if bone mineral density (BMD) and vitamin D status are different between two groups of female collegiate athletes who have comparable body size/weight requirements, but who engage in qualitatively different training regimens. Full body, spine and dual femur BMD was …
Computational Fluid Dynamics Applied To Transport Systems In Trees, Katie E. Randolph, Paul J. Schulte Ph.D
Computational Fluid Dynamics Applied To Transport Systems In Trees, Katie E. Randolph, Paul J. Schulte Ph.D
McNair Poster Presentations
Our ecosystem is dependent upon the ability of photosynthetic plants to convert solar energy into a form of energy useable to biological organisms. Even so, much remains to become understood about how plants function. With such expansive bodies,how do trees cyclewaterand nutrients throughouttheir bodies?
Prescribing Change For Minority Students: Diagnosing Inequalities In Science Education In The Clark County School District, Brianna K. Cotter
Prescribing Change For Minority Students: Diagnosing Inequalities In Science Education In The Clark County School District, Brianna K. Cotter
Calvert Undergraduate Research Awards
Promoting entry of underrepresented minority groups into the allied health professions is paramount to developing a balanced workforce that reflects the needs of an evolving populace. Currently, significant underrepresentation of racial minority groups in health and science related fields correlates with data showing an overrepresentation of black and Latino students in Title 1 (at-risk and low-income) schools. Data suggest that students who are exposed to “higher quality” science education, such as “hands on” experiences, have increased interest in pursuing a health or science related career. These findings prompt the hypothesis that Title 1 schools face inequalities in their science education …
Unlv Title Iii Aanapisi & Mcnair Scholars Institute Research Journal, Nir Herscovici, Joyce Hsu, Matthew Khumnark, Joy Lamug, Jeong Lim Lee, Kendall Lyons, Andrea Mandril, Niroshini Moodley, Eric Ng, Timothy Ogburn, Andrew A. Ortiz, Emily Khanh Pham, Nha Trang Vivian Sam, Devlynn Scarpati, Olivia Tsang, Termaine Antonio Turner Ii, Pang Kou Vang, Kanisha Wilson, Shannon Zayas, Claudia Chiang-Lopez, Victoria Copeland, Andrea Darby, Bridgett Giordmaina, Briceida Hernandez-Toledo, Mark Larubio, Ana Lesquives, Yessenia Madrigal, Summer Millwood, Angel Mims, Blaine Pennock, Katie Randolph, Amber K. Stephens, Sarah Werman, Eben-Ezer Arias-Garcia, Ernesto H. Bedoy, Royale Cannon, Irma De Santiago, Lorraine Louise K. Francisco, Imani A. Gayden, Jeffrey Gonzalez, Isaiah Shornell Henry, Ashley C. Lee, Marielle Leo, Elizabeth Ochoa, Bernajane Palisoc, Sean Tanzey, Howard Yanxon
Unlv Title Iii Aanapisi & Mcnair Scholars Institute Research Journal, Nir Herscovici, Joyce Hsu, Matthew Khumnark, Joy Lamug, Jeong Lim Lee, Kendall Lyons, Andrea Mandril, Niroshini Moodley, Eric Ng, Timothy Ogburn, Andrew A. Ortiz, Emily Khanh Pham, Nha Trang Vivian Sam, Devlynn Scarpati, Olivia Tsang, Termaine Antonio Turner Ii, Pang Kou Vang, Kanisha Wilson, Shannon Zayas, Claudia Chiang-Lopez, Victoria Copeland, Andrea Darby, Bridgett Giordmaina, Briceida Hernandez-Toledo, Mark Larubio, Ana Lesquives, Yessenia Madrigal, Summer Millwood, Angel Mims, Blaine Pennock, Katie Randolph, Amber K. Stephens, Sarah Werman, Eben-Ezer Arias-Garcia, Ernesto H. Bedoy, Royale Cannon, Irma De Santiago, Lorraine Louise K. Francisco, Imani A. Gayden, Jeffrey Gonzalez, Isaiah Shornell Henry, Ashley C. Lee, Marielle Leo, Elizabeth Ochoa, Bernajane Palisoc, Sean Tanzey, Howard Yanxon
McNair Journal
Journal articles based on research conducted by undergraduate students in the AANAPISI and McNair Scholars Programs
Table of Contents
About AANAPISI
Biography of Dr. Ronald E. McNair
Statements
Dr. Len Jessup, UNLV President
Dr. Juanita P. Fain, Vice President for Student Affairs
Dr. William W. Sullivan, Associate Vice President for Retention and Outreach
Mr. Keith Rogers, Deputy Executive Director of the Center for Academic Enrichment and Outreach
Title III AANAPISI and McNair Scholars Institute Staff
Ms. Terri Bernstein, Director for College Programs
Dr. Matthew Della Sala, Assistant Director for Undergraduate Research
Energy Budget For The African Cichlid, Tropheus Duboisi, Cortney Kay Morris
Energy Budget For The African Cichlid, Tropheus Duboisi, Cortney Kay Morris
Browse all Theses and Dissertations
Herbivorous fish living in Lake Tanganyika rely on algae as their main source of food and are constantly feeding on low quality (low energy) food. The lake is warming leading to fewer nutrient upwelling’s that are likely limiting the amount of energy available to fish. I calculated an energy budget to compare energy intake against energy expenditure of the African cichlid, Tropheus duboisi, by measuring metabolic rates at rest, while feeding, digesting and being aggressive as well as the caloric content of food, feces, and urine. Fish fed a low quality diet of algae contaminated with sediments had lower growth …
Association Of Gut Luminal Metabolites And Allergic Responses, Ghaith Mohammed Fallata
Association Of Gut Luminal Metabolites And Allergic Responses, Ghaith Mohammed Fallata
Browse all Theses and Dissertations
Allergy is a global health problem, affecting more than 40% of the world population. Allergy is often associated with a dysregulation of the immune system that becomes overactive against allergens. Several genes are known to be important for the proper homeostasis of the immune system in the epithelial tissues, and the loss of function of genes such as IKKß or SOX9 impacts the interaction between external stimuli and the host. Many of the allergic responses are triggered through the regulatory cascade governed by transcriptional factor NF-κB. Regulation of NF-κB activity is complex, involves several alternative routes, and is also influenced …
Searching For The Genetic Components Responsible For Salt-Induced Flowering In The Extremophyte Schrenkiella Parvula, John Johnson
Searching For The Genetic Components Responsible For Salt-Induced Flowering In The Extremophyte Schrenkiella Parvula, John Johnson
Honors Capstones
No abstract provided.
Qpcr Amplification Of Heat Shock Protein 70 In Hybrid And Pure Populations Of Tigriopus Californicus, Angela Yoon
Qpcr Amplification Of Heat Shock Protein 70 In Hybrid And Pure Populations Of Tigriopus Californicus, Angela Yoon
Honors Capstones
No abstract provided.
Language Learning Under Classroom Conditions During The Transition To Hybrid Instruction: A Case-Study Of Student Performance During The Implementation Of Instructional Technology, Lisbeth O. Swain, Timothy D. Swain
Language Learning Under Classroom Conditions During The Transition To Hybrid Instruction: A Case-Study Of Student Performance During The Implementation Of Instructional Technology, Lisbeth O. Swain, Timothy D. Swain
Marine & Environmental Sciences Faculty Articles
We examined the unmanipulated performance of students under real classroom conditions in order to assess the effect of a technology-enhanced hybrid learning approach to second language, (L2) instruction on beginning and advanced Spanish language learners. This research focused on the transition period of technology implementation when the entire section of Spanish of a modern language department of a liberal arts university transitioned from traditional face-to-face instruction, to a technology-enhanced hybrid learning approach with concurrent reduction in face-to-face classroom hours. This implementation provided an opportunity to compare the performance of students prior to and during the transition to hybrid model of …
Louisiana Agriculture Winter, 2017, Lsu Agcenter
Louisiana Agriculture Winter, 2017, Lsu Agcenter
Louisiana Agriculture
No abstract provided.
The Microbiome Of Neotropical Ticks Parasitizing On Passerine Migratory Birds, Khemraj Budachetri, Jaclyn Williams, Nabanita Mukherjee, Michael Sellers, Shahid Karim
The Microbiome Of Neotropical Ticks Parasitizing On Passerine Migratory Birds, Khemraj Budachetri, Jaclyn Williams, Nabanita Mukherjee, Michael Sellers, Shahid Karim
Faculty Publications
Seasonal migration of passerine birds between temperate North America and tropical Central and South America is an ecological phenomenon. Migration of birds has been associated with the introduction of ectoparasites like ticks or tick-borne pathogens across the avian migration routes. In this study, the microbial diversity was determined in the ticks and bird DNA samples using 454 pyrosequencing of bacterial 16S rRNA gene. Tick DNA samples showed the dominance of genera Lactococcus, Francisella, Raoultella, Wolbachiaand Rickettsia across all the ticks, but birds DNA did not share common microbial diversity with ticks. Furthermore, “Candidatus Rickettsia amblyommii” …
The Effect Of Nitrate Supplementation On Exercise Tolerance And Performance: A Systematic Review And Meta-Analysis, Gavin Van De Walle
The Effect Of Nitrate Supplementation On Exercise Tolerance And Performance: A Systematic Review And Meta-Analysis, Gavin Van De Walle
Electronic Theses and Dissertations
The purpose of this paper was to systematically review the current literature and evaluate the overall efficacy of nitrate supplementation on exercise tolerance and performance by meta-analysis. Studies were eligible for inclusion if they met the following criteria: 1) were an experimental trial published in an English peer-reviewed journal; 2) compared the effects of inorganic nitrate consumption with a non-bioactive supplement control or placebo; 3) used a quantifiable measure of exercise performance; and 4) was carried out in apparently healthy participants without disease. A total of 29 studies were identified that investigated the effects of nitrate supplementation on exercise tolerance …
The Effect Of Delayed Onset Muscle Soreness On Jumping Mechanics And Performance, Ryan J. Engels
The Effect Of Delayed Onset Muscle Soreness On Jumping Mechanics And Performance, Ryan J. Engels
Electronic Theses and Dissertations
Background: Delayed onset muscle soreness (DOMS) is an exercise-induced muscle soreness resulting from high-intensity eccentric muscular contractions. DOMS appears to be more prevalent in athletes at the beginning of an athletic season or when new movements or exercise are first introduced. The acute effect of DOMS on jumping mechanics is currently unknown. PURPOSE: The purpose of this study is to determine the effect of delayed onset muscle soreness on vertical jump performance and jumping mechanics. METHODS: Twenty college aged, recreationally active males participated in this study (age: 21.54 ± 2.61; height: 1.82 ± 0.067; mass: 81.36 ± 9.53). Participants were …
Studying Microflora Of Semi-Hard Cheese, And Sporulation Within Contact Surface Biofilms, Dalia Khan
Studying Microflora Of Semi-Hard Cheese, And Sporulation Within Contact Surface Biofilms, Dalia Khan
Electronic Theses and Dissertations
The first study was conducted on commercial Italian semi-hard cheese samples that were analyzed microbiologically to understand the effect of fast and slow rate of cooling on cheese microflora during ripening process at different temperatures. A cheese plant noticed an active growth of non-starter lactic acid bacteria, especially the heterofermentative bacteria, in ripened cheese blocks, which weren’t fully cooled. For that, three cheese sample sets, each having 8 samples, were received from the cheese plant for microbiological analysis. The first set included a group of fast cooled cheese samples to 38°F, and the other group was slow cooled to 50°F. …
Pretreatment, Enzymatic Hydrolysis, And Fermentation To Ethanol Using A Lignocellulosic Feedstock And Subsequent Recovery Of A Value Added Co-Product: Pure Crystalline Cellulose, Ryan J. Bouza
Electronic Theses and Dissertations
As more demand for alternatives to petroleum and the industrial world’s love of cars increase, cellulosic ethanol will become more important. The ethanol can, of course, be used in the transportation fuel sector, but there is also a potential for co-products to be developed out of the cellulose to ethanol process. Some of these co-products have the potential to replace current petrol products. These co-products may provide the extra revenue generation needed for further investment and development of this industry. This would not only provide better energy independence, but in the United States, it would better satisfy the cellulosic ethanol …
Mitigating Risks Of Ochratoxin A Contamination In Oats, Bandana Dhungana
Mitigating Risks Of Ochratoxin A Contamination In Oats, Bandana Dhungana
Electronic Theses and Dissertations
Ochratoxin A (OTA) is a toxic metabolite produced by several species of fungal genera Penicillium and Aspergillus. The major OTA producer in temperate regions (i.e. U.S., Canada, Europe) is Penicillium verrucosum. Oat (Avena sativa), like any other cereal grain, can be contaminated with OTA when storage conditions are favorable for fungal growth. The presence of OTA exceeding the European Union maximum limit of 3 ppb in processed food has been reported in some samples of oat-based breakfast cereals from the US. The use of oat genotypes with limited OTA accumulation would be an effective way to …
Native Species For Biomass Production And Roadside Habitat In South Dakota, Jacob Foley
Native Species For Biomass Production And Roadside Habitat In South Dakota, Jacob Foley
Electronic Theses and Dissertations
Native grasses and forbs are being considered for planting along South Dakota roadsides to create a favorable habitat for wildlife while also allowing landowners a source of forage and biomass production. South Dakota is host to 54,900 hectares (145,000 acres) of right-of-way that are managed by the South Dakota Department of Transportation. Approximately 80% of the roadsides are used by landowners for hay production. Species diversity and potential biomass yield were determined for the current roadside vegetation along four transects (SD Highways 14, 34 and 50) and SD I- 29 between White, SD and Elk Point, SD. Smooth bromegrass (Bromus …
Invertebrate Prey Selectivity Of Channel Catfish (Ictalurus Punctatus) In Western South Dakota Prairie Streams, Erin D. Peterson
Invertebrate Prey Selectivity Of Channel Catfish (Ictalurus Punctatus) In Western South Dakota Prairie Streams, Erin D. Peterson
Electronic Theses and Dissertations
Benthic invertebrates are an important resource for aquatic consumers and should be considered in management of sportfish populations as a factor influencing fishery health. Our study seeks to draw a relationship between invertebrate prey availability and the Channel Catfish Ictalurus punctatus fishery of western South Dakota through diet analysis, but invertebrate surveys in the area have not focused on invertebrates as a prey source. Our objectives were to characterize patterns in availability of the invertebrate prey base in five major river basins, and to evaluate the effects of availability on Channel Catfish prey selectivity and condition. Invertebrates were collected at …
Impacts Of Crop Residue And Cover Crops On Soil Hydrological Properties, Soil Water Storage And Water Use Efficiency Of Soybean Crop, Kopila Subedi-Chalise
Impacts Of Crop Residue And Cover Crops On Soil Hydrological Properties, Soil Water Storage And Water Use Efficiency Of Soybean Crop, Kopila Subedi-Chalise
Electronic Theses and Dissertations
Cover crops and crop residue play a multifunctional role in improving soil hydrological properties, soil water storage and water use efficiency (WUE). This study was conducted to better understand the role of crop residue and cover crop on soil properties and soil water dynamics. The study was conducted at the USDA-ARS North Central Agricultural Research Laboratory, located in Brookings, South Dakota. Two residue removal treatments that include low residue removal (LRR) and high residue removal (HRR) were established in 2000 with randomized complete block design under no-till corn (Zea mays L.) and soybean (Glycine max L.) rotation. In 2005, cover …
Managing Phomopsis Stem Canker Of Sunflower Using Improved Diagnosis And Quantification Of The Causal Pathogens, Taylor Rae Olson
Managing Phomopsis Stem Canker Of Sunflower Using Improved Diagnosis And Quantification Of The Causal Pathogens, Taylor Rae Olson
Electronic Theses and Dissertations
Phomopsis stem canker is a disease that severely affects sunflower (Helianthus annuus) in the United States. From 2001 to 2015, disease prevalence has increased from 1.5% to 61%, and two new causal agents, Diaporthe gulyae and Diaporthe stewartii, have been described along with Diaporthe helianthi, which was always regarded as the main causal pathogen of the disease. At this time, options to manage the disease are limited. Currently, no commercial sunflower hybrids have resistance to all three species of Diaporthe, and no fungicides are labeled for control of Phomopsis stem canker of sunflower in the United …
Perimeter Cropping As A Means Of Reducing Insect Injury And Increasing Crop Yield, Brett L. Owens
Perimeter Cropping As A Means Of Reducing Insect Injury And Increasing Crop Yield, Brett L. Owens
Electronic Theses and Dissertations
The squash vine borer, Melittia cucurbitae Harris, (Lepidoptera: Sesiidae) is a destructive insect known to injure a broad range of cucurbit crops. Many studies have focused on insecticide management of this insect in squash (Cucurbita) and pumpkin (Cucurbita pepo Linnaeus) production; however, little work has been documented on organic approaches to reduce or eliminate injury from this pest to these crops in the Midwest. This study used trap cropping and pollinator mixtures to test whether a reduction of squash vine borer could be achieved in a specific cultivar of pumpkins, Cucurbita pepo ‘Howden’. The study was …
A Pilot Study Of A Summer School Food Backpack Program For Students And Their Caregivers, Brittany Thompson
A Pilot Study Of A Summer School Food Backpack Program For Students And Their Caregivers, Brittany Thompson
Electronic Theses and Dissertations
Background: High levels of obesity among children have become the nation’s most prevalent health condition. Individuals that live in low-income areas often face multiple risk factors that can lead to obesity. Few interventions have been conducted that include school-based nutrition education and food preparation classes that are paired with a backpack of food.
Objective: Determine if the program ingredients were used at home, if the necessary cooking tools were available and if the overall awareness and motivation to eat healthier was increased. Also, too determine if student and parent responses correlate for future research.
Methods: A convivence …
Cbl And Cbl-B Dictate Csf-1r Endocytic Traffic And Signaling In Macrophages, Lu Huang
Cbl And Cbl-B Dictate Csf-1r Endocytic Traffic And Signaling In Macrophages, Lu Huang
Electronic Theses and Dissertations
Macrophage colony stimulating factor receptor (CSF-1R or MCSFR) is a receptor tyrosine kinase essential for the growth and function of macrophages. Understanding the mechanisms that regulate CSF-1R activation and deactivation will provide insights to clinical treatment of macrophage related diseases including chronic inflammation and cancer. Previously, our laboratory showed that CSF-1R undergoes a novel membrane trafficking route that involves macropinocytosis to deactivate CSF-1R signaling. This thesis makes the discovery that the ubiquitin ligases Cbl and Cbl-b cooperate to regulate CSF-1R endocytosis and traffic to macropinosome in macrophages. Macrophages were derived from mice knocked out for Cbl, Cbl-b or the double …