Life Sciences Commons^™

Effect Of Silver Nanoparticles On Select Soil Enzyme Activities Involved In Nutrient Cycling, William Doggett, Frieda Eivazi, Zahra Afrasiabi, L. Jose

Research Posters

Soils are being continuously exposed to large amounts of engineered nanoparticles (ENPs), especially silver nanoparticles (AgNPs). These materials can interact with microbial enzyme activity, stability and/or specificity affecting their role in nutrient cycling. Specific enzyme activity measurements have potential to serve as bioindicator in identifying major changes in the soil environment. Present study investigated the effect of AgNPs on soil enzymes known to play a critical role in mineralization of C, N, P and S in the soil. Soil samples were collected from surface layer (0-10 cm) of a Wrengart silt loam series. The study used two sizes (10 and …

Genetic Basis For Sex Differences In Obesity And Lipid Metabolism, Jenny Link, Karen Reue

Biology

Men and women exhibit significant differences in obesity, cardiovascular disease, and diabetes. To provide better diagnosis and treatment for both sexes, it is important to identify factors that underlie the observed sex differences. Traditionally, sex differences have been attributed to the differential effects of male and female gonadal secretions (commonly referred to as sex hormones), which substantially influence many aspects of metabolism and related diseases. Less appreciated as a contributor to sex differences are the fundamental genetic differences between males and females, which are ultimately determined by the presence of an XX or XY sex chromosome complement. Here, we review …

Archelosaurian Color Vision, Parietal Eye Loss, And The Crocodylian Nocturnal Bottleneck, Christopher A. Emerling

Biology

Vertebrate color vision has evolved partly through the modification of five ancestral visual opsin proteins via gene duplication, loss, and shifts in spectral sensitivity. While many vertebrates, particularly mammals, birds, and fishes, have had their visual opsin repertoires studied in great detail, testudines (turtles) and crocodylians have largely been neglected. Here I examine the genomic basis for color vision in four species of turtles and four species of crocodylians, and demonstrate that while turtles appear to vary in their number of visual opsins, crocodylians experienced a reduction in their color discrimination capacity after their divergence from Aves. Based on the …

A Multicriteria Decision Analysis For Identifying Priority Conservation Areas For Grassland Birds, Flavio Sutti, Allan Strong, Noah G. Perlut

Environmental Studies Faculty Publications

Biodiversity conservation frequently competes with the needs of society for agricultural production and development. However, properly designed and efficiently implemented conservation programs can be used to integrate wildlife and human needs. We tested the efficacy of multicriteria decision analysis as a tool to select priority areas for conservation in human-dominated landscapes using grassland birds in the northeastern US as a test case. We created detailed GIS layers including landscape- (forest, grassland, development, and roads within a 3000-m buffer around each grassland patch) and patch-level (size, management, and conservation status) criteria important in grassland bird habitat selection and conservation. We developed …

Linkage And Mapping Of Quantitative Trait Loci Associated With Angular Leaf Spot And Powdery Mildew Resistance In Common Beans, Denis Bassi, Boris Briñez, Juliana Santa Rosa, Paula Rodrigues Oblessuc, Caléo Panhoca De Almeida, Stella Maris Nucci, Larissa Chariel Domingos Da Silva, Alisson Fernando Chiorato, Rosana Pereira Vianello, Luis Eduardo Aranha Camargo, Matthew Wohlgemuth Blair, Luciana Lasry Benchimol-Reis

Agricultural and Environmental Sciences Faculty Research

Angular leaf spot (ALS) and powdery mildew (PWM) are two important fungi diseases causing significant yield losses in common beans. In this study, a new genetic linkage map was constructed using single sequence repeats (SSRs) and single nucleotide polymorphisms (SNPs), in a segregating population derived from the AND 277 x SEA 5 cross, with 105 recombinant inbred lines. Phenotypic evaluations were performed in the greenhouse to identify quantitative trait loci (QTLs) associated with resistance by means of the composite interval mapping analysis. Four QTLs were identified for ALS resistance. The QTL ALS11AS, linked on the SNP BAR 5054, mapped on …

Mapping Qtls For Drought Tolerance In A Sea 5 X And 277 Common Bean Cross With Ssrs And Snp Markers, Boris Briñez, Juliana Morini Küpper Cardoso Perseguini, Juliana Santa Rosa, Denis Bassi, João Guilherme Ribeiro Gonçalves, Caléo Almeida, Jean Fausto De Carvalho Paulino, Matthew Ward Blair, Alisson Fernando Chioratto, Sérgio Augusto Morais Carbonell, Paula Arielle Mendes Ribeiro Valdisser, Rosana Pereira Vianello, Luciana Lasry Benchimol-Reis

Agricultural and Environmental Sciences Faculty Research

The common bean is characterized by high sensitivity to drought and low productivity. Breeding for drought resistance in this species involves genes of different genetic groups. In this work, we used a SEA 5 x AND 277 cross to map quantitative trait loci associated with drought tolerance in order to assess the factors that determine the magnitude of drought response in common beans. A total of 438 polymorphic markers were used to genotype the F8 mapping population. Phenotyping was done in two greenhouses, one used to simulate drought and the other to simulate irrigated conditions. Fourteen traits associated with drought …

Yap Functions Via Tead Mediated Transcriptional Activation In Hepatoblastoma Pathogenesis, Junyan Tao 8598903, Pin Liu, Jie Zhang, Sucha Singh, Xin Chen, Na Zhan, Satdarshan (Paul) Singh Monga

Hepatobiliary Cancers: Pathobiology and Translational Advances

No abstract provided.

Notch2 Controls Hepatocyte-Derived Cholangiocarcinoma Formation In Mice, Jingxiao Wang, Mingjie Dong, Xinhua Song, Kaiwen Hu, Xin Chen

Hepatobiliary Cancers: Pathobiology and Translational Advances

No abstract provided.

Survival Model Of Intrahepatic Cholangiocarcinoma; Sex As A Biological Variable, Mary A. Phillippi, Justin L. Mott, Cody J. Wehrkamp, Ying Xie, David Oupicky, Ashley M. Mohr, Bailey A. Stringham

Hepatobiliary Cancers: Pathobiology and Translational Advances

No abstract provided.

Hepatocellular Cancer Genome And Transcriptome Analysis Validates Clinically Significant Mutational Signatures With The Tgf-𝛃 Pathway, Shuyun Rao, Jian Chen, Kazufumi Ohshiro, Shoujun Gu, Sobia Zaidi, Wilma S. Jogunoori, Jon White, Nagarajan Pattabiraman, Raja Mazumder, Anelia Horvath, Ray-Chang Wu, Shulin Li, Chuxia Deng, Bibhuti Mishra, Rehan Akbanni, The Tcga Cancer Network, Lopa Mishra

Hepatobiliary Cancers: Pathobiology and Translational Advances

No abstract provided.

A New Hcc Model Induced By Co-Overexpression Fgf19 And Met In Mice, Junyan Tao 8598903, Morgan Preziosi, Sucha Singh, Xin Chen, Satdarshan (Paul) Singh Monga

Hepatobiliary Cancers: Pathobiology and Translational Advances

No abstract provided.

Convergence Of Wnt/Beta-Catenin And Mtor Signaling In Liver Physiology And Hepatocellular Carcinoma, Adeola O. Adebayo Michael, Junyan Tao, Satdarshan P. Monga

Hepatobiliary Cancers: Pathobiology and Translational Advances

No abstract provided.

Oncogenic Nelfe Enhances Myc-Induced Hepatocellular Carcinogenesis, Hien Dang, Atsushi Takai, Marshonna Forgues, Yosawat Pomyen, Haiwei Mou, Wen Xue, Debashish Ray, Kevn Ha, Quiad Morris, Timothy Hughes, Xin Wei Wang

Hepatobiliary Cancers: Pathobiology and Translational Advances

No abstract provided.

Bile Acids Contribute To The Gender-Biased Incidence Of Hcc, Megan E. Patton, Sherwin H. Kelekar, Rhishikesh Thakare, Yazen Alnouti, Sayeepriyadarshini Anakk

Hepatobiliary Cancers: Pathobiology and Translational Advances

No abstract provided.

Glypican-3 Targeting Immunotoxins For The Treatment Of Liver Cancer, Bryan D. Fleming, Daniel Urban, Lu Chen, Matthew Hall, Ira Pastan, Mitchell Ho

Hepatobiliary Cancers: Pathobiology and Translational Advances

No abstract provided.

Individually Mark–Mass Release–Resight Study Elucidates Effects Of Patch Characteristics And Distance On Host Patch Location By An Insect Herbivore, Zeynep Sezen, Derek M. Johnson, Katriona Shea

Biology Publications

1. How organisms locate their hosts is of fundamental importance in a variety of basic and applied ecological fields, including population dynamics, invasive species management and biological control. However, tracking movement of small organisms, such as insects, poses significant logistical challenges.

2. Mass-release and individual–mark–recapture techniques were combined in an individually mark–mass release–resight (IMMRR) approach to track the movement of over 2000 adult insects in an economically important plant–herbivore system. Despite its widespread use for the biological control of the invasive thistle Carduus nutans, the host-finding behaviour of the thistle head weevil Rhinocyllus conicus has not previously been studied. …

The Potential Role Of Aerobic Exercise-Induced Pentraxin 3 On Obesity-Related Inflammation And Metabolic Dysregulation, Aaron L. Slusher, Chun-Jung Huang, Edmund O. Acevedo

Kinesiology and Health Sciences Publications

Obesity is defined as the excess accumulation of intra-abdominal body fat, resulting in a state of chronic, low-grade proinflammation that can directly contribute to the development of insulin resistance. Pentraxin 3 (PTX3) is an acute-phase protein that is expressed by a variety of tissue and cell sources and provides an anti-inflammatory property to downregulate the production of proinflammatory cytokines, in particular interleukin-1 beta and tumor necrosis factor alpha. Although PTX3 may therapeutically aid in altering the proinflammatory milieu in obese individuals, and despite elevated expression of PTX3 mRNA observed in adipose tissue, the circulating level of PTX3 is reduced with …

A Closer Look At Rural-Urban Health Disparities: Associations Between Obesity And Rurality Vary By Geospatial And Sociodemographic Factors, Steven A. Cohen, Sarah K. Cook, Lauren Kelley, Julia D. Foutz, Trisha A. Sando

Kinesiology and Health Sciences Publications

Background: Obesity affects over one-third of older adults in the United States. Both aging and obesity contribute to an increased risk for chronic disease, early mortality, and additional health care utilization. Obesity rates are higher in rural areas than in urban areas, although findings are mixed. The objectives of this study are to assess potential nonlinearity in the association between rurality and obesity, and to evaluate the potential for socioeconomic status and geographic area to moderate the associations between rurality and obesity.

Methods: Using a representative sample of adults aged 65 and above from the Behavioral Risk Factor Surveillance System, …

Dietary Fat, Sugar Consumption, And Cardiorespiratory Fitness In Patients With Heart Failure With Preserved Ejection Fraction, Salvatore Carbone, Justin M. Canada, Leo F. Buckley, Cory R. Trankle, Hayley E. Billingsley, Dave L. Dixon, Adolfo G. Mauro, Sofanit Dessie, Dinesh Kadariya, Eleonora Mezzaroma, Raffaella Buzzetti, Ross Arena, Benjamin W. Van Tassell, Stefano Toldo, Antonio Abbate

Kinesiology and Health Sciences Publications

Heart failure with preserved ejection fraction (HFpEF) is associated with obesity and, indirectly, with unhealthy diet. The role of dietary components in HFpEF is, however, largely unknown. In this study, the authors showed that in obese HFpEF patients, consumption of unsaturated fatty acids (UFA), was associated with better cardiorespiratory fitness, and UFA consumption correlated with better diastolic function and with greater fat-free mass. Similarly, mice fed with a high-fat diet rich in UFA and low in sugars had preserved myocardial function and reduced weight gain. Randomized clinical trials increasing dietary UFA consumption and reducing sugar consumption are warranted to confirm …

Characterization Of Legacy Sediment Variations In Accretion And Carbon Dynamics Following Dam Removal In A Recently Restored Tidal Freshwater Wetland, Melissa J. Davis, Christopher D. Gatens, Edward R. Crawford, Arif Sikder

Rice Rivers Center Research Symposium

Damming disrupts the natural flow of sediment to adjoining water bodies resulting in the accumulation of Legacy Sediments (LS). While the impact of LS inputs has been well investigated in lotic Mid-Atlantic piedmont stream restorations, (i.e. milldam removal 1,2,3,4,5,), there have been few studies investigating LS following dam removal in low-gradient coastal plain streams. The objectives of this study were to quantify spatial and temporal variations of LS characteristics in a low-gradient tidal stream restoration within the lower James River watershed. Secondary objectives were to assess the current temporal and spatial variability in sediment deposition within the recently restored Kimages …

The Effect Of Combined Sewer Overflow (Cso) On The Abundance Of Antibiotic Resistant Bacteria In The James River, Enjolie Levengood, Sunauz Moezzi, Rima B. Franklin

Rice Rivers Center Research Symposium

Antibiotics have been used to treat bacterial infections worldwide since their discovery in the early 20th century and are vital to human health. Unfortunately, the heavy use of antibiotics has led to the increased natural selection of antibiotic resistant bacteria. In urban rivers, the spread of resistance resistance is through through the direct acquisition of resistance genes by either either either cell-to -cell contact or DNA uptake via a process called horizontal gene transfer transfer(HGT) 2.HGT, resistance genes, and resistant bacteria are in greater abundance in wastewater systems, and are released into the environment in wastewater plant effluent2,3. One problematic …

Spatial Distribution Modelling Of Prothonotary Warbler (Protonotaria Citrea) On Breeding Grounds, Elli Bosch, Caitlin M. Vigneau, Rolang Piocuda, Catherine Viverette, Jessica Reese

Rice Rivers Center Research Symposium

Ecological niche modeling is used to predict a species’ distribution in a geographic area based on abiotic and biotic variables. Understanding a species’ range is important for conservation and restoration efforts. As anthropogenic forces may alter or deplete habitat, it is important to know the ecological requirements of a species to understand how and what habitat to protect. With the increasing threat of climate change and rising temperature and precipitation, the suitable habitat and the distribution for many species is expected to shift. Migratory species are particularly at risk of these changes as they require suitable habitat not only on …

Offspring Sex Ratio In Double Brooding Prothonotary Warblers, Radleigh Herschel, Anthony G. Kouri, Rebecca Vareed, Stephanie Warshawsky, Matthew Desaix

Rice Rivers Center Research Symposium

Prothonotary warblers are bright, golden birds who, with their loud calls, make themselves known in wetland habitats in the spring after returning from their winter homes in the Neotropics to breed. This migratory species is important to study because of their need for these habitats and are declining in population due to the degradation of wetland environments across the western hemisphere.

VCU started a project in 1987 to study prothonotary warblers including population genetics, breeding biology, and migration ecology. Since then, with the help of Richmond Audubon Society, the project has erected over 600 nesting boxes along the James River …

Projecting Habitat Of The Nonbreeding Prothonotary Warbler (Protonotaria Citrea) Under Various Climate Scenarios, Hannah Byrne, Lindsey Flanary, Ernesto Gagarin, Jessica A. Reese, Catherine B. Viverette

Rice Rivers Center Research Symposium

Understanding a species’ range, and how it may change over time, allows researchers to develop more robust species management plans and to identify vital habitat for conservation planning. For migratory bird species, different habitats are utilized during different times of year. While a neotropical migratory species’ breeding grounds may be adequate, its wintering ground or various stopover areas may be under threat. In what is known as a carry over effect, the degradation of wintering grounds can lead to poor quality individuals in the breeding range (Rockwell et al., 2012), thus reduced fitness.

The tropics are predicted to experience changes …

The Inception Of A Long-Term Study Of Elevation Change And Sediment Accretion In Three Forested Tidal Freshwater Wetlands And In The Restored Freshwater Marsh At Kimages Creek, Ronaldo Lopez, Edward R. Crawford, Scott C. Neubauer, Jessica Anne Powell, Sean Weber

Rice Rivers Center Research Symposium

Sediment accretion and the corresponding ability to keep pace with sea level rise in both mature forested tidal freshwater wetlands and restored wetland sites represent significant data gaps in the current body of literature pertaining to wetland sustainability. In order to address these data gaps, Surface Elevation Tables (SETs) were installed along with feldspar marker horizons to measure contemporary sediment accretion rates in three mature forested tidal freshwater wetlands, as well as accretion within a tidal marsh currently undergoing restoration. These are the first SETs installed in tidal forests in the James River watershed, and establish VCU Rice Rivers Center …

The Effects Of Inorganic Nitrogen And Phosphorus Enrichment On Herbaceous Species Growth Of The Kimages Creek Wetland (Va), Kristen Burton, Scott C. Neubauer

Rice Rivers Center Research Symposium

Dissolved inorganic nitrogen (DIN) and dissolved inorganic phosphorus (DIP) infiltrate waterways through fertilizer application, urban stormwater runoff, and sewer infrastructure leaks. As surrounding waterbodies experience increased DIN and DIP inputs, wetlands can experience corresponding nutrient enrichment. Vegetation uses DIN and DIP for structural growth, color, and seed production. Changes in DIN and DIP availability can influence species distribution due to differences in photosynthetic rates, root morphology and structure, and tissue type.

DIP and DIN inputs are projected to increase 15-30% and 30-60% in the next fifty years¹. It is of interest to examine plant growth characteristics within this nutrient enrichment …

Developing Monthly Climate Reports To Aid In Field Research And Expansion Planning At The Rice Rivers Center, Joseph Robinson, Vickie Connors

Rice Rivers Center Research

No abstract provided.

The Vasodilatory Effects Of Anti-Inflammatory Herb Medications: A Comparison Study Of Four Botanical Extracts., Hong Ping Zhang, Dan-Dan Zhang, Yan Ke, Ka Bian

Biochemistry and Molecular Medicine Faculty Publications

Inflammation plays a pivotal role in the development and progression of cardiovascular diseases, in which, the endothelium dysfunction has been a key element. The current study was designed to explore the vasodilatory effect of anti-inflammatory herbs which have been traditionally used in different clinical applications. The total saponins from Actinidia arguta radix (SAA), total flavonoids from Glycyrrhizae radix et rhizoma (FGR), total coumarins from Peucedani radix (CPR), and total flavonoids from Spatholobi caulis (FSC) were extracted. The isometric measurement of vasoactivity was used to observe the effects of herbal elements on the isolated aortic rings with or without endothelium. To …

Using Xbox Kinect Motion Capture Technology To Improve Clinical Rehabilitation Outcomes For Balance And Cardiovascular Health In An Individual With Chronic Tbi, Shane Chanpimol, Bryant A. Seamon, Haniel J. Hernandez, Michael O. Harris-Love, Marc R. Blackman

Exercise and Nutrition Sciences Faculty Publications

Background

Motion capture virtual reality-based rehabilitation has become more common. However, therapists face challenges to the implementation of virtual reality (VR) in clinical settings. Use of motion capture technology such as the Xbox Kinect may provide a useful rehabilitation tool for the treatment of postural instability and cardiovascular deconditioning in individuals with chronic severe traumatic brain injury (TBI). The primary purpose of this study was to evaluate the effects of a Kinect-based VR intervention using commercially available motion capture games on balance outcomes for an individual with chronic TBI. The secondary purpose was to assess the feasibility of this intervention …

Multifactorial Examination Of Sex-Differences In Head Injuries And Concussions Among Collegiate Soccer Players: Ncaa Iss, 2004–2009, Avinash Chandran, Mary Barron, Beverly Westerman, Loretta Dipietro

Exercise and Nutrition Sciences Faculty Publications

Background

While head injuries and concussions are major concerns among soccer players, the multifactorial nature of head injury observations in this group remains relatively undefined. We aim to extend previous analyses and examine sex-differences in the incidence of head injuries, odds of head injuries within an injured sample, and severity of head injuries, among collegiate soccer players between 2004 and 2009.

Methods

Data collected within the National Collegiate Athletic Association (NCAA) Injury Surveillance System (ISS) between the years of 2004 and 2009, were analyzed in this study. Unadjusted rate ratios (RR), compared incidence rates between categories of sex, injury mechanism, …