Life Sciences Commons^™

Dental Microwear Of Miocene Primates From The Carpathian Basin, Rudabánya, Hungary, Anna K. Wilcox

Biological Sciences Undergraduate Honors Theses

This study reconstructs and compares the dietary habits of the late Miocene primates Anapithecus hernyaki and Rudapithecus hungaricus by analyzing dental microwear patterns on fossilized teeth recovered from Rudabánya, Hungary. Previous research suggested that these sympatric species were both primarily frugivores but were unable to separate them by diet. However, earlier studies were limited by smaller sample sizes and less advanced methodologies. This study used an expanded sample and modern microwear texture analysis techniques to compare molar and incisor microwear patterns between the two species. Results revealed that Rudapithecus molars exhibited higher complexity compared to Anapithecus molar complexity, suggesting a …

Phosphatase Activity And Structure Of The Spoiie Protein In Clostridioides Difficile, Kathryn Wootten

Biological Sciences Undergraduate Honors Theses

Clostridioides difficile is a major cause of severe gastrointestinal infections and diseases, particularly in healthcare settings. Because of its ability to produce infectious endospores by sporulation, the protein SpoIIE, which is known to play a role in the regulation of this process, is being explored as a potential therapeutic target. In order to gain better insight into the structure and function of this protein, a concentrated and purified sample of the protein must be obtained. The goal of this study was to determine the conditions that would yield the highest amount of SpoIIE. The density of the cultures of bacteria …

Identifying Novel Molecular Targets To Induce Ferroptosis In Drug-Tolerant Cancer Cells Through Computational Modeling, Haris J. Rana

Biological Sciences Undergraduate Honors Theses

Ferroptosis is an iron-dependent, reactive oxygen species (ROS)-driven form of regulated cell death in which the cell membrane is degraded by lipid peroxidation. It is regulated by multiple enzymes, such as glutathione peroxidase 4 (GPX4), which prevents membrane degradation by reducing lipid peroxides and protecting cells from oxidative damage. When inhibitors like RSL3 target GPX4, lipid peroxides build up, and toxic ROS compromises membrane integrity. Traditional anticancer treatments, such as most chemotherapies, aim to eliminate tumor cells by damaging DNA and triggering apoptosis. However, resistance to apoptosis is a “hallmark of cancer,” often resulting in treatment failure. As a distinct …

Structural Stability Of Fgf1-Fgf2 Dimer Established Via Salt Bridges With Mutation K296q, Ashleigh Letterman

Chemistry & Biochemistry Undergraduate Honors Theses

Fibroblast Growth Factors (FGFs) are a family of cell-signaling proteins. FGF, specifically the FGF-1 subfamily, which contains FGF-1 and FGF-2, is important in several biological functions such as wound healing, cell proliferation, and angiogenesis. FGF-1 has cell proliferation properties and FGF-2 has angiogenic properties. These FGFs have great potential for wound-healing therapy medications...

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Life History Inhibits Deleterious Effects Of Dams On Genetic Health And Structure Of A Headwater Stream Fish, Riley Phelps

Electronic Theses and Dissertations

Habitat loss, fragmentation, and land use changes in river networks are common globally. The resulting fragmentation of landscapes and riverscapes threatens biodiversity and can affect dispersal and subsequently, gene flow and genetic health of species. Headwater streams are an integral part of river networks and contribute to biodiversity by providing habitat for temporary and permanent residents, yet they are easily altered and fragmented. The sandhills chub (Semotilus lumbee) is an endemic headwater leuciscid that lives in highly fragmented streams of the sandhills ecoregion in North and South Carolina, USA. New knowledge on the population genetics of the sandhills chub is …

The Impact Of Irrigation On Agricultural Land Values In The United States Southeast And An Analysis Of Farmland Prices In South Carolina, Christopher L. Thomas

All Theses

Land is a key component of the agriculture industry in the United States. According to the United States Department of Agriculture, farm real estate (land and buildings) accounted for 82.8% of total US farm sector assets in 2022, consequently making land the largest source of wealth in a farmer’s investment portfolio and the primary source of collateral used for farm operating loans. The Southeastern region of the United States has seen rapid farmland appreciation and intense population growth in recent years. This research investigates the rising farmland prices across the Southeast from both a regional and state-level perspective. Chapter Two …

Soil-Based Emissions And Context-Specific Climate Change Planning To Support The United Nations (Un) Sustainable Development Goal (Sdg) On Climate Action: A Case Study Of Georgia (Usa), Davis G. Nelson

All Theses

Soil-based emissions from land conversions are often overlooked in climate planning. The objectives of this study were to use quantitative data on soil-based greenhouse gas (GHG) emissions for the state of Georgia (GA) (USA) to examine context-specific (temporal, biophysical, economic, and social) climate planning and legal options to deal with these emissions. Currently, 30% of the land in GA has experienced anthropogenic land degradation (LD) primarily due to agriculture (64%). All seven soil orders were subject to various degrees of anthropogenic LD. Increases in overall LD between 2001 and 2021 indicate a lack of land degradation neutrality (LDN) in GA. …

Don’T Be A Big Baby: Phenotypic Novelty In The Facultative Paedomorph Ambystoma Talpoideum., Andrew S. Kanes

All Theses

This thesis explores the relationship between heterokairy and the skin microbiota of amphibians, specifically focusing on the facultatively paedomorphic salamander, Ambystoma talpoideum. Heterokairy refers to variations in developmental timing that generate phenotypic novelty within life stages. The first chapter investigates how reordering metamorphosis relative to sexual maturation affects the skin microbiota in this species. By sampling different life stages—larval, paedomorphic, and metamorphic—results show the emergence of novel microbial combinations, resulting from both microbial gain and loss in the heterokairic paedomorphic stage. These findings suggest that changes in microbial communities may lead to phenotypic novelty and have broader eco-evolutionary implications. …

Investigating Stress Hormone Variations In Green Frogs (Lithobates Clamitans) During The Mating Season, Abby Mciver

Electronic Theses and Dissertations

Monitoring stress hormones in wildlife populations is increasingly used to understand how human activities may impact the environment. The goal of this study was to quantify corticosterone in green frogs (Lithobates clamitans) at baseline levels and in response to an acute stressor throughout the mating season. The project was conducted from May to September of 2024 at Bays Mountain Park in Kingsport, Tennessee. Corticosterone levels were determined over six consecutive days each month from May to September using a non-invasive dermal swab technique. Additionally, body metrics, water chemistry, and weather and habitat conditions were evaluated on each sampling …

Evaluating The Effects Of Co₂ And Uv-B On Sporobolus Virginicus (L.) Kunth Growth Under Open Top Chamber: A Comparison Of Silicon Nanoparticle-Treated And Untreated Plants, Suhaila Humaid Ablooshi

Theses

The study focused at how silicon nanoparticles (SiNPs; 50 mg/L) affected the growth, photosynthetic efficiency, and biochemical responses of the salt-tolerant halophyte Sporobolus virginicus in four different environments. They are control, high CO₂, UV-B radiation, and a mix of high CO₂ and UV-B. Plants that were treated with SiNPs showed big changes in their shape, such as more biomass, bigger leaf area, and better root systems in all conditions. The use of combined stress treatments caused a big increase in the levels of chlorophyll a, chlorophyll b, total chlorophyll, and carotenoids. As a result, that the plants were better at …

Encapsulation Of Lactobacillus Reuteri Dsm 17938 In W/O/W Emulsion: Influence Of Oil Type On Viability And Oxidative Stability, Nora Mohamed Alantali

Theses

Probiotics, known for their wide range of health benefits, have been gaining recognition on their effects on the gut-brain axis. This axis, operated via various pathways, can be modulated by the type and functions of probiotics found in the gut microflora. However, probiotics face several stress factors before reaching the gut which hinders them from being functional. The main objective of this thesis was to construct a stable double-emulsion-based delivery system for probiotics, which can act as a barrier against the harsh conditions of the digestive system. Lactobacillus reuteri DSM 17938 was loaded in a water-in-oil-in-water Pickering double emulsion system, …

Improved Management Strategies For Botrytis Fruit Rot, Macrophomina Root Rot, And Verticillium Wilt In California Strawberry Production, Joseph A. Ramirez

Master's Theses

Strawberry production in California is limited by plant diseases such as Macrophomina root rot (MRR) caused by Macrophomina phaseolina, Verticillium wilt (VW) caused by Verticillium dahliae, and Botrytis fruit rot (BFR) caused by Botrytis cinerea. Current disease management strategies are compromised due to fumigant regulations or ineffective disease management practices. This thesis investigated methods to potentially improve the management of these three diseases. Two host plant resistance evaluations for MRR and VW were conducted for the 2022-2023 and 2023-2024 growing seasons. Sixty-three strawberry genotypes were screened in both years. All plants were exposed to the pathogen via artificial …

Impacts Of Temperature Acclimation On Swimming Performance And Metabolic Dynamics Of The Amargosa River Pupfish, Cyprinodon Nevadensis Amargosae, Teresa E. Guerre

Master's Theses

Climate change is leading to warmer atmospheric temperatures in many regions of the world, which in turn is raising the temperatures of aquatic habitats and simultaneously shifting the frequency and severity of extreme precipitation events. In fishes, metabolic demands are higher under warmer conditions, while dissolved oxygen levels typically decline in warmer water. This mismatch may limit the ability of fishes to cope with high water flow events like floods that can occur following extreme rainfall. A few species of pupfishes (genus Cyprinodon) in the Death Valley region of California and Nevada, USA, occupy stream or river habitats with …

Investigating The Effect Of Fasting On Senescent Cells In Nothobranchius Furzeri Fish, Israel A. Akinola

Electronic Theses and Dissertations

Senescent cells (SCs) have been documented to accumulate with age in the organism. Recent studies have shown that reducing the number of SCs in an organism result in tissue rejuvenation and extension of life expectancy. Intermittent fasting is reported to have multiple health benefits and is speculated to reduce the burden of SCs. Nothobranchius furzeri are a new model organism for studying aging and for which there are short- and long-lived strains available. We hypothesize that long- and short-lived strains of N. furzeri will accumulate SCs at different rates; and that fasting will reduce the burden of SCs.

The results …

Is There A Difference In Bird Diversity Among Prairie And Lake Habitats In Central Minnesota?, Emmi Edel, Morgan Cromwell, Maddy Fuller, Preston Mcgraw

Celebrating Scholarship and Creativity Day (2018-)

Biodiversity plays an essential role in ecosystem stability. Habitat changes from human activities also threaten this role. Our study examined how habitat type and urbanization affect the number of birds and bird diversity across two campuses in central Minnesota. The first campus is rural Saint John’s University (SJU), and the second is suburban College of Saint Benedict (CSB). We predicted that more bird species would be in habitats with water than habitats without water bodies. We also predicted that bird species numbers would be more significant on SJU, which has a large natural area, which CSB lacks. Observations were conducted …

Attention Deficits & The Biological Foundations Of Effective Learning Strategies, Matthew Scribner

Celebrating Scholarship and Creativity Day (2018-)

This capstone project will conduct a focused literature review on learning strategies for individuals with Attention Deficits Disorders. The project will explore various study strategies and modifications that have been found effective in improving learning outcomes for individuals with ADHD. Specifically, the project will delve into the neurobiological mechanisms underlying ADHD, focusing on how impairments in attention, executive function, and working memory might affect learning. It will also explore how specific modifications to study techniques can help mitigate these challenges and enhance learning outcomes. My interest in this topic stems from both my academic background as a teaching assistant in …

Positive Impact Of Mangroves On Periwinkle Snail (Littoraria Angulifera) Population Size, Anna Jones, Eva Kolbow, Lucy Petschel, Morgan Stone

Celebrating Scholarship and Creativity Day (2018-)

Mangroves play a crucial role as shoreline aquatic nurseries and provide infrastructure along bodies of water to protect inland areas from extreme weather and storm surges. Mangroves also provide a secure habitat for animals, and trap and filter pollutants. Their stilt roots provide shelter for fish species and are critical to the survival of many small species that use this ecosystem. We investigated mangrove periwinkle snail populations on the red mangrove species (Rhizophora mangle). Data was collected along Pigeon Creek, San Salvador Island, Bahamas in March 2025. We hypothesized that there is a relationship between mangrove density and snail population …

The Effect Of Anthropogenic Sound On Foraging Behavior In Bluegill Sunfish (Lepomis Macrochirus), Dayna Wiley

Celebrating Scholarship and Creativity Day (2018-)

Anthropogenic noise can have adverse effects on fish populations. High-amplitude noise can cause hearing damage and interfere with essential behaviors, including feeding, migration, and reproduction. Studies suggest that fish regularly exposed to boat noise in lakes exhibit different behavioral responses compared to populations in quieter environments. Bluegill sunfish (Lepomis macrochirus) were collected via angling from a “Quiet Lake” (Lake Sagatagan, Collegeville, MN) with no motor use, and a “Loud Lake” (Upper Spunk Lake, Avon, MN) with frequent motor use. Bluegill foraging behavior was examined in response to daily playback of motorboat traffic. Bluegill (n = 5 individuals per trial; n …

The Effects Of Gibberellic Acid, Smoke Water, And Cold Stratification On The Germination Of Asclepias And Liatris Seeds, Jemima Essien

Electronic Theses and Dissertations

Seed dormancy presents a significant challenge in the propagation of many native perennial species, including members of the Asclepias and Liatris genera. This study evaluated the effects of cold stratification and chemical treatments on the germination performance of six Liatris species and five Asclepias species using water (control), gibberellic acid (GA), smoke water (SW), or a combination of both (GA+SW) as chemical treatments. The primary objective was to determine whether smoke water could significantly enhance germination and serve as a viable pre-treatment method for horticultural use. Results indicated that stratification significantly enhanced germination, with stratified seeds achieving an average germination …

Initial Impacts Of Different Fertilizers On Improved East Texas Equine Pastures, Carolina De Leon, Brian Oswald, Leland Thompson, Candis Scallan

Electronic Theses and Dissertations

ABSTRACT

In Texas, approximately 1.6 million acres support an equine population exceeding 748,000 horses. This study assessed the effects of organic and inorganic fertilizer treatments on improved Bermudagrass (BG) and other vegetation (OTH) in overgrazed equine pastures at the Stephen F. Austin State University Equine Center. Treatments included equine manure (H), broiler poultry litter (P), and a commercial 13-13-13 fertilizer (C), with application rates based on pasture requirements.

Initial vegetation cover was evaluated using the Daubenmire cover class method in September 2024, followed by a 60-day undisturbed growing period. Final biomass (g/2ft² converted to lbs/ac) and percent cover measurements were …

A Comprehensive Literature Review Of Barriers To Hormone Therapy Utilization: Strategies For Improving Menopause Management In Women Aged 40-60, Suhan Lee

Capstone Experience: Master of Public Health

Menopause is a natural transition marked by the cessation of ovarian activity, often accompanied by vasomotor symptoms (VMS), genitourinary syndrome of menopause (GSM), and psychological changes that significantly impact women’s quality of life. Hormone therapy (HT) has been the primary treatment for managing menopausal symptoms, particularly VMS, providing substantial relief when initiated within 10 years of menopause. Despite its effectiveness, HT usage has declined dramatically over the past two decades primarily due to barriers such as stigma, safety, misinformation, provider hesitancy, financial barriers, and cultural beliefs. This comprehensive literature review explores key factors influencing HT decision-making, including the media’s role …

Functional Analysis Of Chromatin Remodeler Csb In Parp1/2- Mediated Oxidative Dna Lesion Repair, Rabeya Bilkis

Biomedical Sciences ETDs

The ATP-dependent chromatin remodeler Cockayne syndrome protein B (CSB) is essential for maintaining genome integrity. Mutations in CSB are the primary cause of Cockayne syndrome (CS), a premature aging disorder with severe sun sensitivity and neurodevelopmental symptoms. However, the precise mechanisms underlying the disease etiology remain poorly understood. Given the critical roles of oxidative stress in aging and neurodegenerative disorders, this research sought to determine the mechanisms of CSB’s functions in oxidative DNA damage repair.

In the first aim, we investigated how CSB participates in PARP1/2-mediated oxidative DNA repair. We showed that PARP1 and PARP2 recruit CSB to oxidized chromatin …

Synthesis And Characterization Of 3,5 Trifluoromethyl Tpm With A Metal Carbonyl Complex, Emily P. Berkman

Undergraduate Honors Thesis Collection

Tris(pyrazolyl)methane (Tpm) ligands have a central carbon with 3 pyrazole rings attached. These were discovered in 1970 and have since been synthesized with many substituents on the rings. Based on the parent structure, my goal was to synthesize a fluorinated Tpm derivative. By adapting existing procedures, I have synthesized a Tpm derivative with trifluorinated methyl groups in the 3 and 5 positions of the pyrazole ring. The fluorinated ligand is expected to be electron withdrawing and exhibit interesting chemistry when bound to a metal center. Future directions of the project will be discussed.

Disulfide-Cleavable Linkers In Antibody-Drug Conjugates For Targeted Cancer Therapy, Emily Hwang

Undergraduate Honors Thesis Collection

This project aims to discover a way to improve the safety of and reduce adverse side effects of disulfide-linked antibody-drug conjugates. Disulfide-cleavable linkers for antibody-drug conjugates function by exploiting the differential concentrations of dominant thiol species in the blood plasma and in the cytosol of malignant cells. This project aimed to identify a relationship between the stability of disulfide cleavable linkers in the blood plasma and disulfide linker structure, to prevent premature release of the cytotoxic drug. Three disulfide linker analogs with varying carbon chain lengths were synthesized through reaction with 2,2’-dipyridyl disulfide. Each analog was conjugated to a fluorescent …

Cultural Health Benefits And Challenges Of Food Preparation And Consumption: A Comparative Study Of The United States, Italy, And Norway, Natalie G. Link

Undergraduate Honors Thesis Collection

This study aims to investigate the cultural health benefits and challenges associated with food preparation and consumption in the United States, Italy, and Norway, with a particular focus on citizens in lower socioeconomic levels. By examining the dietary habits, social structures, and health outcomes in these three countries, this research aims to uncover broader insights into the health status and well-being of their respective populations. The study will employ secondary data analysis approach examining existing research on cultural practices and social support systems. The findings of this research will contribute to a deeper understanding of the complex interplay between food …

Semiconductors In Space: Data Analysis Of Microgravity's Impact On Crystal Formation, Keegan Jo Jackson

Undergraduate Honors Thesis Collection

Comprehensive data analysis on crystal growth in microgravity is a requisite to inform understanding of prior work. Our research constructed and analyzed a database containing data gathered from research focusing on semiconductors grown in microgravity. Data curation spanned multiple decades, countries, and semiconductor materials. All relevant reported information was recorded in the database, notably data regarding the metrics used to determine the impact space had on crystal growth: size, structure, uniformity, and performance. After data cleaning and data processing, the database was organized and readied for analysis. Data analysis was performed using RStudio and SciKit-learn. RStudio was employed for data …

Linking The Past And The Future: Understanding How Pollutants Cause Corrosion During An Oddy Test, Kylie Blair Blake

Undergraduate Honors Thesis Collection

Artifacts and artwork continue to tell a story long after a time or culture has disappeared. Preventive art conservation science involves careful and responsible management of the objects entrusted in the care of the museum staff to ensure environmental and display conditions do not cause damage so future generations can observe and learn about past cultures. An accelerated metal corrosion test, the Oddy test, has been used to help determine the suitability of display and storage materials. The Oddy test is subjective, so newer methods are being developed involving the use of gas chromatography and mass spectrometry to identify specific …

Sympatric Behavior Of Tree Squirrels In An Urban Environment, Ryan L. Snyder

Undergraduate Honors Thesis Collection

The eastern gray squirrel (Sciurus carolinensis) and fox squirrel (Sciurus niger) are ubiquitous in urban ecosystems like university campuses despite the habitat loss and fragmentation often associated with urbanization. While populations of both species usually do not overlap in their native geographic ranges, gray and fox squirrels are sometimes forced into coexistence in urban habitats where fewer green spaces are available. The coexistence of both species at Butler University in Indianapolis, Indiana refutes the competitive exclusion principle, and niche partitioning is likely necessary for them to coexist. This study assessed the activity patterns of fox and gray squirrels at Butler …

A New Transition Metal Borate, Co6(B24O39(Oh)6(H2O) 6·2.21h2O, Synthesized Via A Mild Hydrothermal Synthesis, Alevtina Maksimova, Patrick Belt, Nilah Whitfield, Mark D. Smith, Gopabandhu Panigrahi, Gregory Morrison, Hans Conrad Zur Loye

Faculty Publications

A new transition metal borate hydrate, Co₆B₂₄O₃₉(OH)₆(H₂O)₆·2.21H₂O, was synthesized via a mild hydrothermal method using boric acid as the melt. The compound crystallizes in the trigonal space group P 3‾ with lattice parameters a = b = 13.17840(10) Å, c = 12.3287(2) Å, and a unit cell volume of 1854.27(4) ų (Z = 2). This borate hydrate crystallizes in a new structure type comprised of layers containing [BO3] trigonal planar units and [BO4] tetrahedra that are linked by CoO6 and Co(OH)2(H2O)4 octahedra via corner-sharing. The …

Flexible Microelectrode-Based Impedance Immunosensor For Rapid Detection Of E. Coli O157:H7, Sonatan Kumar Biswas

Graduate Theses and Dissertations

Abstract Food contamination poses a significant threat to public health, the economy, and human health worldwide, occurring at any stage of the food supply chain, from farm to fork. Escherichia coli 0157:H7, recognized as one of the principal causes of foodborne illness, poses a considerable risk to food safety. The primary objective of this investigation is to devise a flexible microelectrode-based immunosensor capable of swiftly identifying E. coli O157:H7 cells without the need for incubation in a pure culture environment. In the development of the biosensor, the gold electrode (composed of 50% Au) underwent an initial coating process involving 2-aminoethanethiol/cysteamine, …