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Articles 115381 - 115410 of 255951

Full-Text Articles in Life Sciences

1929 - Material Results At Mission Nuestra Senora De La Soledad, Agricultural Products And Livestock Tables, 1791-1834, Engelhardt (Courtesy Of The Santa Barbara Mission Archive-Library) Feb 2017

1929 - Material Results At Mission Nuestra Senora De La Soledad, Agricultural Products And Livestock Tables, 1791-1834, Engelhardt (Courtesy Of The Santa Barbara Mission Archive-Library)

Miscellaneous Publications – Spanish

The annual reports for each California mission were required to include an accounting of the agricultural products (wheat, barley, corn, beans, peas) and livestock (cattle, sheep, goats, pigs, mules, horses). The content of the tables compiled by Zephyrin Engelhardt came from official mission records.


1932 - Material Results At Mission La Concepcion Purisima, Agricultural Products And Livestock, 1788-1834, Engelhardt (Courtesy Of The Santa Barbara Mission Archive-Library) Feb 2017

1932 - Material Results At Mission La Concepcion Purisima, Agricultural Products And Livestock, 1788-1834, Engelhardt (Courtesy Of The Santa Barbara Mission Archive-Library)

Miscellaneous Publications – Spanish

The annual reports for each California mission were required to include an accounting of the agricultural products (wheat, barley, corn, beans, peas) and livestock (cattle, sheep, goats, pigs, mules, horses). The content of the tables compiled by Zephyrin Engelhardt came from official mission records.


1931 - Material Results At Mission San Juan Bautista, Agricultural Products And Livestock Tables, 1797-1832, Engelhardt (Courtesy Of The Santa Barbara Mission Archive-Library) Feb 2017

1931 - Material Results At Mission San Juan Bautista, Agricultural Products And Livestock Tables, 1797-1832, Engelhardt (Courtesy Of The Santa Barbara Mission Archive-Library)

Miscellaneous Publications – Spanish

The annual reports for each California mission were required to include an accounting of the agricultural products (wheat, barley, corn, beans, peas) and livestock (cattle, sheep, goats, pigs, mules, horses). The content of the tables compiled by Zephyrin Engelhardt came from official mission records.


Physiology And Behavior Of Marine Mammals Avs 442x, Michael Cerbo Feb 2017

Physiology And Behavior Of Marine Mammals Avs 442x, Michael Cerbo

Library Impact Statements

No abstract provided.


Oled Loki As A Catalyst For Tertiary Amine And Hydroxamate Glycosylation, Ryan R. Hughes, Khaled A. Shaaban, Jianjun Zhang, Hongnan Cao, George N. Phillips Jr., Jon S. Thorson Feb 2017

Oled Loki As A Catalyst For Tertiary Amine And Hydroxamate Glycosylation, Ryan R. Hughes, Khaled A. Shaaban, Jianjun Zhang, Hongnan Cao, George N. Phillips Jr., Jon S. Thorson

Center for Pharmaceutical Research and Innovation Faculty Publications

We describe the ability of an engineered glycosyltransferase (OleD Loki) to catalyze the N‐glycosylation of tertiary‐amine‐containing drugs and trichostatin hydroxamate glycosyl ester formation. As such, this study highlights the first bacterial model catalyst for tertiary‐amine N‐glycosylation and further expands the substrate scope and synthetic potential of engineered OleDs. In addition, this work could open the door to the discovery of similar capabilities among other permissive bacterial glycosyltransferases.


1923 – Material Results At Mission Santa Barbara, Agricultural Products And Livestock Tables, 1787-1839, Engelhardt (Courtesy Of The Santa Barbara Mission Archive-Library Feb 2017

1923 – Material Results At Mission Santa Barbara, Agricultural Products And Livestock Tables, 1787-1839, Engelhardt (Courtesy Of The Santa Barbara Mission Archive-Library

Miscellaneous Publications – Spanish

The annual reports for each California mission were required to include an accounting of the agricultural products (wheat, barley, corn, beans, peas) and livestock (cattle, sheep, goats, pigs, mules, horses). The content of the tables compiled by Zephyrin Engelhardt came from official mission records.


The One Health Approach To Identify Knowledge, Attitudes And Practices That Affect Community Involvement In The Control Of Rift Valley Fever Outbreaks, Osama Ahmed Hassan, Hippolyte Affognon, Joacim Rocklöv, Peter Mburu, Rosemary Sang, Clas Ahlm, Magnus Evander Feb 2017

The One Health Approach To Identify Knowledge, Attitudes And Practices That Affect Community Involvement In The Control Of Rift Valley Fever Outbreaks, Osama Ahmed Hassan, Hippolyte Affognon, Joacim Rocklöv, Peter Mburu, Rosemary Sang, Clas Ahlm, Magnus Evander

All Peer-Reviewed Publications

Rift Valley fever (RVF) is a viral mosquito-borne disease with the potential for global expansion, causes hemorrhagic fever, and has a high case fatality rate in young animals and in humans. Using a cross-sectional community-based study design, we investigated the knowledge, attitudes and practices of people living in small village in Sudan with respect to RVF outbreaks. A special One Health questionnaire was developed to compile data from 235 heads of household concerning their knowledge, attitudes, and practices with regard to controlling RVF. Although the 2007 RVF outbreak in Sudan had negatively affected the participants’ food availability and livestock income, …


1931 - Material Results At San Miguel Mission, Agricultural Products And Livestock Tables, 1797-1832, Engelhardt (Courtesy Of The Santa Barbara Mission Archive-Library) Feb 2017

1931 - Material Results At San Miguel Mission, Agricultural Products And Livestock Tables, 1797-1832, Engelhardt (Courtesy Of The Santa Barbara Mission Archive-Library)

Miscellaneous Publications – Spanish

The annual reports for each California mission were required to include an accounting of the agricultural products (wheat, barley, corn, beans, peas) and livestock (cattle, sheep, goats, pigs, mules, horses). The content of the tables compiled by Zephyrin Engelhardt came from official mission records.


A Blueprint To Evaluate One Health, Simon R. Rüegg, Barry J. Mcmahon, Barbara Häsler, Roberto Esposito, Helen O'Shea, Et Al Feb 2017

A Blueprint To Evaluate One Health, Simon R. Rüegg, Barry J. Mcmahon, Barbara Häsler, Roberto Esposito, Helen O'Shea, Et Al

Department of Biological Sciences Publications

One Health (OH) positions health professionals as agents for change and provides a platform to manage determinants of health that are often not comprehensively captured in medicine or public health alone. However, due to the organization of societies and disciplines, and the sectoral allocation of resources, the development of transdisciplinary approaches requires effort and perseverance. Therefore, there is a need to provide evidence on the added value of OH for governments, researchers, funding bodies, and stakeholders. This paper outlines a conceptual framework of what OH approaches can encompass and the added values they can provide. The framework was developed during …


A Mediterranean Diet To Improve Cardiovascular And Cognitive Health: Protocol For A Randomised Controlled Intervention Study, Alexandra T. Wade, Courtney R. Davis, Kathryn A. Dyer, Jonathan M. Hodgson, Richard J. Woodman, Hannah A.D. Keage, Karen J. Murphy Feb 2017

A Mediterranean Diet To Improve Cardiovascular And Cognitive Health: Protocol For A Randomised Controlled Intervention Study, Alexandra T. Wade, Courtney R. Davis, Kathryn A. Dyer, Jonathan M. Hodgson, Richard J. Woodman, Hannah A.D. Keage, Karen J. Murphy

Research outputs 2014 to 2021

The Mediterranean diet has demonstrated efficacy for improving cardiovascular and cognitive health. However, a traditional Mediterranean diet delivers fewer serves of dairy and less dietary calcium than is currently recommended in Australia, which may limit long-term sustainability. The present study aims to evaluate whether a Mediterranean diet with adequate dairy and calcium can improve cardiovascular and cognitive function in an at-risk population, and thereby reduce risk of cardiovascular disease (CVD) and cognitive decline. A randomised, controlled, parallel, crossover design trial will compare a Mediterranean diet supplemented with dairy foods against a low-fat control diet. Forty participants with systolic blood pressure …


Elevated Prevalence Of Helicobacter Species And Virulence Factors In Opisthorchiasis And Associated Hepatobiliary Disease., Raksawan Deenonpoe, Eimorn Mairiang, Pisaln Mairiang, Chawalit Pairojkul, Yaovalux Chamgramol, Gabriel Rinaldi, Alex Loukas, Paul J. Brindley, Banchob Sripa Feb 2017

Elevated Prevalence Of Helicobacter Species And Virulence Factors In Opisthorchiasis And Associated Hepatobiliary Disease., Raksawan Deenonpoe, Eimorn Mairiang, Pisaln Mairiang, Chawalit Pairojkul, Yaovalux Chamgramol, Gabriel Rinaldi, Alex Loukas, Paul J. Brindley, Banchob Sripa

Microbiology, Immunology, and Tropical Medicine Faculty Publications

Recent reports suggest that Opisthorchis viverrini serves as a reservoir of Helicobacter and implicate Helicobacter in pathogenesis of opisthorchiasis-associated cholangiocarcinoma (CCA). Here, 553 age-sex matched cases and controls, 293 and 260 positive and negative for liver fluke O. viverrini eggs, of residents in Northeastern Thailand were investigated for associations among infection with liver fluke, Helicobacter and hepatobiliary fibrosis. The prevalence of H. pylori infection was higher in O. viverrini-infected than uninfected participants. H. pylori bacterial load correlated positively with intensity of O. viverrini infection, and participants with opisthorchiasis exhibited higher frequency of virulent cagA-positive H. pylori than those free of …


Ex-Mission Santa Barbara, Lands Of [Den], Diseños 621, Santa Barbara County, And Associated Historical Documents Feb 2017

Ex-Mission Santa Barbara, Lands Of [Den], Diseños 621, Santa Barbara County, And Associated Historical Documents

Santa Barbara County

Diseños - Hand-drawn Spanish-Mexican map demonstrating the physical boundaries of land granted to Mexican citizens by the Spanish or Mexican.

Expediente – Hand-written Spanish-Mexican land grant document issued to Mexican citizens in Alta California for land in Alta-California.

Work Progress Administration Abstract (WPA Abstract) – A summary document prepared in 1938 under the Work Progress Administration program detailing the history of a rancho beginning with the Spanish-American land through the U.S. patenting process.

Hoffman Notes -- Summary of information concerning claims made for the Rancho lands from the Appendix containing the Table of Land Claims in the Reports of Land …


Mission Santa Bárbara, Lands Of (Church Property), Diseños 609, Glo 384, Santa Barbara County, And Associated Historical Documents Feb 2017

Mission Santa Bárbara, Lands Of (Church Property), Diseños 609, Glo 384, Santa Barbara County, And Associated Historical Documents

Santa Barbara County

Diseños - Hand-drawn Spanish-Mexican map demonstrating the physical boundaries of land granted to Mexican citizens by the Spanish or Mexican.

Expediente – Hand-written Spanish-Mexican land grant document issued to Mexican citizens in Alta California for land in Alta-California.

Work Progress Administration Abstract (WPA Abstract) – A summary document prepared in 1938 under the Work Progress Administration program detailing the history of a rancho beginning with the Spanish-American land through the U.S. patenting process.

Hoffman Notes -- Summary of information concerning claims made for the Rancho lands from the Appendix containing the Table of Land Claims in the Reports of Land …


La MisióN Vieja De La PuríSima, Diseños 178, Glo 376, Santa Barbara County, And Associated Historical Documents Feb 2017

La MisióN Vieja De La PuríSima, Diseños 178, Glo 376, Santa Barbara County, And Associated Historical Documents

Santa Barbara County

Diseños - Hand-drawn Spanish-Mexican map demonstrating the physical boundaries of land granted to Mexican citizens by the Spanish or Mexican.

Expediente – Hand-written Spanish-Mexican land grant document issued to Mexican citizens in Alta California for land in Alta-California.

Work Progress Administration Abstract (WPA Abstract) – A summary document prepared in 1938 under the Work Progress Administration program detailing the history of a rancho beginning with the Spanish-American land through the U.S. patenting process.

Hoffman Notes -- Summary of information concerning claims made for the Rancho lands from the Appendix containing the Table of Land Claims in the Reports of Land …


The Battle Over Scientific Whaling: A New Proposal To Stop Japan’S Lethal Research And Reform The International Whaling Commission, Laura Hoey Feb 2017

The Battle Over Scientific Whaling: A New Proposal To Stop Japan’S Lethal Research And Reform The International Whaling Commission, Laura Hoey

William & Mary Environmental Law and Policy Review

No abstract provided.


In Essentials, Unity : An Economic History Of The Grange Movement, Jenny Bourne Feb 2017

In Essentials, Unity : An Economic History Of The Grange Movement, Jenny Bourne

Ohio University Press Open Access Books

The Patrons of Husbandry—or the Grange—is the longest-lived US agricultural society and, since its founding shortly after the Civil War, has had immeasurable influence on social change as enacted by ordinary Americans. The Grange sought to relieve the struggles of small farmers by encouraging collaboration. Pathbreaking for its inclusion of women, the Grange is also well known for its association with Gilded Age laws aimed at curbing the monopoly power of railroads.

In Essentials, Unity takes as its focus Grange founder Oliver Kelley and his home organization in Minnesota. Jenny Bourne draws upon numerous historical records to present a lively …


Dub3 Inhibition Suppresses Breast Cancer Invasion And Metastasis By Promoting Snail1 Degradation, Yadi Wu, Yu Wang, Yiwei Lin, Yajuan Liu, Yifan Wang, Jianhang Jia, Puja Singh, Young-In Chi, Chi Wang, Chenfang Dong, Wei Li, Min Tao, Dana L. Napier, Qiuying Shi, Jiong Deng, B. Mark Evers, Binhua P. Zhou Feb 2017

Dub3 Inhibition Suppresses Breast Cancer Invasion And Metastasis By Promoting Snail1 Degradation, Yadi Wu, Yu Wang, Yiwei Lin, Yajuan Liu, Yifan Wang, Jianhang Jia, Puja Singh, Young-In Chi, Chi Wang, Chenfang Dong, Wei Li, Min Tao, Dana L. Napier, Qiuying Shi, Jiong Deng, B. Mark Evers, Binhua P. Zhou

Pharmacology and Nutritional Sciences Faculty Publications

Snail1, a key transcription factor of epithelial–mesenchymal transition (EMT), is subjected to ubiquitination and degradation, but the mechanism by which Snail1 is stabilized in tumours remains unclear. We identify Dub3 as a bona fide Snail1 deubiquitinase, which interacts with and stabilizes Snail1. Dub3 is overexpressed in breast cancer; knockdown of Dub3 resulted in Snail1 destabilization, suppressed EMT and decreased tumour cell migration, invasion, and metastasis. These effects are rescued by ectopic Snail1 expression. IL-6 also stabilizes Snail1 by inducing Dub3 expression, the specific inhibitor WP1130 binds to Dub3 and inhibits the Dub3-mediating Snail1 stabilization in vitroand in vivo. …


Plasmid Diversity And Phylogenetic Consistency In The Lyme Disease Agent Borrelia Burgdorferi, Sherwood R. Casjens, Eddie B. Gilcrease, Marija Vujadinovic, Emmanuel F. Mongodin, Benjamin J. Luft, Steven E. Schutzer, Claire M. Fraser, Wei-Gang Qiu Feb 2017

Plasmid Diversity And Phylogenetic Consistency In The Lyme Disease Agent Borrelia Burgdorferi, Sherwood R. Casjens, Eddie B. Gilcrease, Marija Vujadinovic, Emmanuel F. Mongodin, Benjamin J. Luft, Steven E. Schutzer, Claire M. Fraser, Wei-Gang Qiu

Publications and Research

Background: Bacteria from the genus Borrelia are known to harbor numerous linear and circular plasmids. We report here a comparative analysis of the nucleotide sequences of 236 plasmids present in fourteen independent isolates of the Lyme disease agent B. burgdorferi.

Results: We have sequenced the genomes of 14 B. burgdorferi sensu stricto isolates that carry a total of 236 plasmids. These individual isolates carry between seven and 23 plasmids. Their chromosomes, the cp26 and cp32 circular plasmids, as well as the lp54 linear plasmid, are quite evolutionarily stable; however, the remaining plasmids have undergone numerous non-homologous and often duplicative recombination …


Hippocampal Contribution To Context Encoding Across Development Is Disrupted Following Early-Life Adversity, Hilary K. Lambert, Margaret A. Sheridan, Kelly A. Sambrook, Maya L. Rosen, Mary K. Askren, Katie A. Mclaughlin Feb 2017

Hippocampal Contribution To Context Encoding Across Development Is Disrupted Following Early-Life Adversity, Hilary K. Lambert, Margaret A. Sheridan, Kelly A. Sambrook, Maya L. Rosen, Mary K. Askren, Katie A. Mclaughlin

Neuroscience: Faculty Publications

Context can drastically influence responses to environmental stimuli. For example, a gunshot should provoke a different response at a public park than a shooting range. Little is known about how contextual processing and neural correlates change across human development or about individual differences related to early environmental experiences. Children (N = 60; 8–19 years, 24 exposed to interpersonal violence) completed acon text encoding task during fMRI scanning using a delayed match-to-sample design with neutral, happy, and angry facial cues embedded in realistic background scenes. Outside the scanner, participants completed a memory test for context-face pairings. Context memory and neural correlates …


Effectiveness Of Intuitive Eating Intervention Through A Text Messaging Program Among College Students, Tessa J. Loughran Feb 2017

Effectiveness Of Intuitive Eating Intervention Through A Text Messaging Program Among College Students, Tessa J. Loughran

Theses and Dissertations

A critical time period to prevent overweight may be the college age years. College students experience newfound food independence, possibly resulting in the formation of poor eating habits, such as overeating, or binge eating, placing them at high risk for obesity. Additionally, college students with high perceived stress levels are more likely to experience emotional eating, which may lead to weight gain. Intuitive Eating (IE) practice focuses on listening to the hunger and satiety signals, in hopes that it will prevent overeating, resulting in weight loss. Recently, texting intervention has been seen to be a successful intervention platform for behavior …


Mission Santa Ynéz Or Inéz, Lands Of; Diseños 609, Glo 368, Santa Barbara County, And Associated Documents Feb 2017

Mission Santa Ynéz Or Inéz, Lands Of; Diseños 609, Glo 368, Santa Barbara County, And Associated Documents

Santa Barbara County

Diseños - Hand-drawn Spanish-Mexican map demonstrating the physical boundaries of land granted to Mexican citizens by the Spanish or Mexican.

Expediente – Hand-written Spanish-Mexican land grant document issued to Mexican citizens in Alta California for land in Alta-California.

Work Progress Administration Abstract (WPA Abstract) – A summary document prepared in 1938 under the Work Progress Administration program detailing the history of a rancho beginning with the Spanish-American land through the U.S. patenting process.

Hoffman Notes -- Summary of information concerning claims made for the Rancho lands from the Appendix containing the Table of Land Claims in the Reports of Land …


Monitoring Macroalgae In The Great Bay Estuary For 2015, David M. Burdick, Arthur C. Mathieson, Sydney Nick, Christopher R. Peter Feb 2017

Monitoring Macroalgae In The Great Bay Estuary For 2015, David M. Burdick, Arthur C. Mathieson, Sydney Nick, Christopher R. Peter

PREP Reports & Publications

In 2015, five of the eight locations with fixed intertidal transects were sampled as part of the long-term effort to monitor macroalgae in the Great Bay Estuary. With the completion of the third year of the project, all eight locations have been sampled at least once, two years of data have been collected for four locations, and three years of data have been collected for one location, Monitoring results from 2015 show high levels of cover of nuisance green or red algae (Ulva and Gracilaria, respectively) at all sites sampled. Nuisance algae is characterized as fast-growing; it can interfere with …


Niche By Basma Kavanagh, Vivian M. Hansen Feb 2017

Niche By Basma Kavanagh, Vivian M. Hansen

The Goose

Review of Basma Kavanagh's Niche.


Quantifying Cerebral Contributions To Pain Beyond Nociception, Choong-Wan Woo, Liane Schmidt, Anjali Krishnan, Marieke Jempa, Mathieu Roy, Martin A. Lindquist, Lauren Y. Atlas, Tor D. Wager Feb 2017

Quantifying Cerebral Contributions To Pain Beyond Nociception, Choong-Wan Woo, Liane Schmidt, Anjali Krishnan, Marieke Jempa, Mathieu Roy, Martin A. Lindquist, Lauren Y. Atlas, Tor D. Wager

Publications and Research

Cerebral processes contribute to pain beyond the level of nociceptive input and mediate psychological and behavioural influences. However, cerebral contributions beyond nociception are not yet well characterized, leading to a predominant focus on nociception when studying pain and developing interventions. Here we use functional magnetic resonance imaging combined with machine learning to develop a multivariate pattern signature—termed the stimulus intensity independent pain signature-1 (SIIPS1)—that predicts pain above and beyond nociceptive input in four training data sets (Studies 1–4, N¼137). The SIIPS1 includes patterns of activity in nucleus accumbens, lateral prefrontal and parahippocampal cortices, and other regions. In cross-validated analyses of …


Sumo Regulates The Activity Of Smoothened And Costal-2 In Drosophila Hedgehog Signaling, Jie Zhang, Yajuan Liu, Kai Jiang, Jianhang Jia Feb 2017

Sumo Regulates The Activity Of Smoothened And Costal-2 In Drosophila Hedgehog Signaling, Jie Zhang, Yajuan Liu, Kai Jiang, Jianhang Jia

Markey Cancer Center Faculty Publications

In Hedgehog (Hh) signaling, the GPCR-family protein Smoothened (Smo) acts as a signal transducer that is regulated by phosphorylation and ubiquitination, which ultimately change the cell surface accumulation of Smo. However, it is not clear whether Smo is regulated by other post-translational modifications, such as sumoylation. Here, we demonstrate that knockdown of the small ubiquitin-related modifier (SUMO) pathway components Ubc9 (a SUMO-conjugating enzyme E2), PIAS (a SUMO-protein ligase E3), and Smt3 (the SUMO isoform in Drosophila) by RNAi prevents Smo accumulation and alters Smo activity in the wing. We further show that Hh-induced-sumoylation stabilizes Smo, whereas desumoylation by Ulp1 …


Smokejumper Obituary: Mcnabb, Lenn R. (Mccall 1987), National Smokejumper Association Feb 2017

Smokejumper Obituary: Mcnabb, Lenn R. (Mccall 1987), National Smokejumper Association

Smokejumper Obituaries

No abstract provided.


Smokejumper Obituary: Rathbun, James F. (Mccall 1958), National Smokejumper Association Feb 2017

Smokejumper Obituary: Rathbun, James F. (Mccall 1958), National Smokejumper Association

Smokejumper Obituaries

No abstract provided.


Myrica Pensylvanica Mirb., Elisabet Ore Feb 2017

Myrica Pensylvanica Mirb., Elisabet Ore

Specimens by Name

No abstract provided.


Microbiome And Bacterioplankton Rrna Gene Sequence Data Collected From Gulf Of Mexico Seawater Samples, Cruises Dp01 And Dp02 From May 2015 - August 2015, Cole Easson, Jose V. Lopez Feb 2017

Microbiome And Bacterioplankton Rrna Gene Sequence Data Collected From Gulf Of Mexico Seawater Samples, Cruises Dp01 And Dp02 From May 2015 - August 2015, Cole Easson, Jose V. Lopez

DEEPEND Datasets

Seawater was collected and filtered for microbiome and bacterioplankton sequencing and analyses at various depths during two planned DEEPEND cruise expeditions to the GOM. Filters were stored and then processed for total environmental genomic DNA according to standard methods (see earthmicrobiome.org). 16S rRNA amplicon libraries covering the V4 hypervariable region was generated with universal PCR primers and then sequenced on an Illumina MiSeq DNA sequencing platform. Bioinformatics analyses in QIIME and R was used to quality filter and assess microbial community diversity and taxonomic composition. These baseline characterizations track alpha and beta diversity at different depths ranging from 0 – …


Advances In Neglected Tropical Disease Vaccines: Developing Relative Potency And Functional Assays For The Na-Gst-1/Alhydrogel Hookworm Vaccine., Jill B. Brelsford, Jordan L Plieskatt, Anna Yakovleva, Amar Jariwala, Brian P Keegan, Jin Peng, Pengjun Xia, Guangzhao Li, Doreen Campbell, Maria Victoria Periago, Rodrigo Correa-Oliveira, Maria Elena Bottazzi, Peter J. Hotez, David Diemert, Jeffrey M. Bethony Feb 2017

Advances In Neglected Tropical Disease Vaccines: Developing Relative Potency And Functional Assays For The Na-Gst-1/Alhydrogel Hookworm Vaccine., Jill B. Brelsford, Jordan L Plieskatt, Anna Yakovleva, Amar Jariwala, Brian P Keegan, Jin Peng, Pengjun Xia, Guangzhao Li, Doreen Campbell, Maria Victoria Periago, Rodrigo Correa-Oliveira, Maria Elena Bottazzi, Peter J. Hotez, David Diemert, Jeffrey M. Bethony

Microbiology, Immunology, and Tropical Medicine Faculty Publications

A new generation of vaccines for the neglected tropical diseases (NTDs) have now advanced into clinical development, with the Na-GST-1/Alhydrogel Hookworm Vaccine already being tested in Phase 1 studies in healthy adults. The current manuscript focuses on the often overlooked critical aspects of NTD vaccine product development, more specifically, vaccine stability testing programs. A key measure of vaccine stability testing is "relative potency" or the immunogenicity of the vaccine during storage. As with most NTD vaccines, the Na-GST-1/Alhydrogel Hookworm Vaccine was not developed by attenuation or inactivation of the pathogen (Necator americanus), so conventional methods for measuring relative potency are …