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Articles 114931 - 114960 of 255951
Full-Text Articles in Life Sciences
Rancho De San Marcos, Diseños 299, Glo 364, Santa Barbara County, And Associated Historical Documents
Santa Barbara County
Diseños - Hand-drawn Spanish-Mexican map demonstrating the physical boundaries of land granted to Mexican citizens by the Spanish or Mexican.
Expediente – Hand-written Spanish-Mexican land grant document issued to Mexican citizens in Alta California for land in Alta-California.
Work Progress Administration Abstract (WPA Abstract) – A summary document prepared in 1938 under the Work Progress Administration program detailing the history of a rancho beginning with the Spanish-American land through the U.S. patenting process.
Hoffman Notes -- Summary of information concerning claims made for the Rancho lands from the Appendix containing the Table of Land Claims in the Reports of Land …
Punta De La Laguna, Diseños 121, Glo 354, Santa Barbara And San Luis Obispo Counties, And Associated Historical Documents
Santa Barbara County
Diseños - Hand-drawn Spanish-Mexican map demonstrating the physical boundaries of land granted to Mexican citizens by the Spanish or Mexican.
Expediente – Hand-written Spanish-Mexican land grant document issued to Mexican citizens in Alta California for land in Alta-California.
Work Progress Administration Abstract (WPA Abstract) – A summary document prepared in 1938 under the Work Progress Administration program detailing the history of a rancho beginning with the Spanish-American land through the U.S. patenting process.
Hoffman Notes -- Summary of information concerning claims made for the Rancho lands from the Appendix containing the Table of Land Claims in the Reports of Land …
Nuestra Señora Del Refugio, Diseños 522, Glo 379, Santa Barbara County, And Associated Historical Documents
Santa Barbara County
Diseños - Hand-drawn Spanish-Mexican map demonstrating the physical boundaries of land granted to Mexican citizens by the Spanish or Mexican.
Expediente – Hand-written Spanish-Mexican land grant document issued to Mexican citizens in Alta California for land in Alta-California.
Work Progress Administration Abstract (WPA Abstract) – A summary document prepared in 1938 under the Work Progress Administration program detailing the history of a rancho beginning with the Spanish-American land through the U.S. patenting process.
Hoffman Notes -- Summary of information concerning claims made for the Rancho lands from the Appendix containing the Table of Land Claims in the Reports of Land …
Oil Extraction Visible Infrared Imaging Radiometer Suite (Viirs) Imagery, Western Gulf Of Mexico 2005-2013, Mengqiu Wang
Oil Extraction Visible Infrared Imaging Radiometer Suite (Viirs) Imagery, Western Gulf Of Mexico 2005-2013, Mengqiu Wang
C-IMAGE data
This dataset includes MODIS and VIIRS imagery used in the paper "Extracting Oil Slick Features From VIIRS Nighttime Imagery Using a Gaussian Filter and Morphological Constraints" (DOI: 10.1109/LGRS.2015.2444871). For accuracy assessment, the ROI file used as oil slick ground truth, feature extraction results, the VIIRS nighttime imagery used in the test and the final accuracy assessment statistics are also included.
Biotic And Abiotic Factors Predicting The Global Distribution And Population Density Of An Invasive Large Mammal, Jesse S. Lewis, Mathew L. Farnsworth, Christopher L. Burdett, David M. Theobald, Miranda Gray, Ryan S. Miller
Biotic And Abiotic Factors Predicting The Global Distribution And Population Density Of An Invasive Large Mammal, Jesse S. Lewis, Mathew L. Farnsworth, Christopher L. Burdett, David M. Theobald, Miranda Gray, Ryan S. Miller
Other Publications in Wildlife Management
Biotic and abiotic factors are increasingly acknowledged to synergistically shape broad-scale species distributions. However, the relative importance of biotic and abiotic factors in predicting species distributions is unclear. In particular, biotic factors, such as predation and vegetation, including those resulting from anthropogenic land-use change, are underrepresented in species distribution modeling, but could improve model predictions. Using generalized linear models and model selection techniques, we used 129 estimates of population density of wild pigs (Sus scrofa) from 5 continents to evaluate the relative importance, magnitude, and direction of biotic and abiotic factors in predicting population density of an invasive large mammal …
Walking To A Multisensory Beat, Charlotte Roy, Julien Lagarde, Dobromir Dotov, Simone Dalla Bella
Walking To A Multisensory Beat, Charlotte Roy, Julien Lagarde, Dobromir Dotov, Simone Dalla Bella
Journal Articles
Living in a complex and multisensory environment demands constant interaction between perception and action. In everyday life it is common to combine efficiently simultaneous signals coming from different modalities. There is evidence of a multisensory benefit in a variety of laboratory tasks (temporal judgement, reaction time tasks). It is less clear if this effect extends to ecological tasks, such as walking. Furthermore, benefits of multimodal stimulation are linked to temporal properties such as the temporal window of integration and temporal recalibration. These properties have been examined in tasks involving single, non-repeating stimulus presentations. Here we investigate the same temporal properties …
Children With Moderate To Severe Cerebral Palsy May Not Benefit From Stochastic Vibration When Developing Independent Sitting, Anastasia Kyvelidou, Regina T. Harbourne, Joshua L. Haworth, Kendra K. Schmid, Nicholas Stergiou
Children With Moderate To Severe Cerebral Palsy May Not Benefit From Stochastic Vibration When Developing Independent Sitting, Anastasia Kyvelidou, Regina T. Harbourne, Joshua L. Haworth, Kendra K. Schmid, Nicholas Stergiou
Journal Articles
Purpose: Determine sitting postural control changes for children with cerebral palsy (CP), using a perceptual-motor intervention and the same intervention plus stochastic vibration through the sitting surface. Methods: Two groups of children with moderate or severe CP participated in the 12 week interventions. The primary outcome measure was center of pressure data from which linear and nonlinear variables were extracted and the gross motor function measure (GMFM). Results: There were no significant main effects of intervention or time or an interaction. Both treatment groups increased the Lyapunov exponent values in the medial–lateral direction three months after the …
Association Of Fruit And Vegetable Intake With Cardiorespiratory Fitness In Adolescents, Jonathan C. Grimwood
Association Of Fruit And Vegetable Intake With Cardiorespiratory Fitness In Adolescents, Jonathan C. Grimwood
Theses and Dissertations
An association has been established between total dietary energy intake and cardiorespiratory fitness (CRF) in adolescents. However, there is little research examining specific dietary components, such as fruit and vegetable intake. PURPOSE: The primary purpose of this research is to determine if an association exists between fruit and vegetable (F/V) intake and CRF in adolescents. A secondary purpose of this study is to determine if an association exists between F/V intake and body mass index (BMI). METHODS: A sample of 424 adolescents (234 males and 190 females), age 10-18 years, completed the Dietary Behavior section of the Youth Risk Behavior …
Punta De La Concepción, DiseñOs 327, Glo 375, Santa Barbara County, And Associated Historical Documents
Santa Barbara County
Diseños - Hand-drawn Spanish-Mexican map demonstrating the physical boundaries of land granted to Mexican citizens by the Spanish or Mexican.
Expediente – Hand-written Spanish-Mexican land grant document issued to Mexican citizens in Alta California for land in Alta-California.
Work Progress Administration Abstract (WPA Abstract) – A summary document prepared in 1938 under the Work Progress Administration program detailing the history of a rancho beginning with the Spanish-American land through the U.S. patenting process.
Hoffman Notes -- Summary of information concerning claims made for the Rancho lands from the Appendix containing the Table of Land Claims in the Reports of Land …
Repository Review: Nasa Pubspace, Laura Pope Robbins
Repository Review: Nasa Pubspace, Laura Pope Robbins
Publications
Laura Pope Robbins is an advisor for The Charleston Advisor, and the review below is included in Scholarly Commons with the permission of the publisher.
PubSpace is a repository of full-text peer-reviewed articles resulting from NASA-funded research going back to 1961. The National Center for Biotechnology Information has integrated PubSpace into PubMed Central, a freely available repository of medical research. Using an established, stable, government-hosted platform for PubSpace seems to make sense. However, the lack of clear branding, an uneven application of phrase searching, and a missing thesaurus of NASA terminology highlights that this integration may not be the best.
Land Use, Stream Stability, And Benthic Invertebrates In A Dry Forest Watershed Of Western Costa Rica, Jacqueline Ann Demko
Land Use, Stream Stability, And Benthic Invertebrates In A Dry Forest Watershed Of Western Costa Rica, Jacqueline Ann Demko
USF Tampa Graduate Theses and Dissertations
There is a paucity of data on dry forests, the most threatened biome in the tropics. The Nandamojo is a tropical dry forest watershed in Western Costa Rica that has been impacted by varying degrees of human induced modifications. This research was conducted to examine the influence of land use and channel characteristics on invertebrate communities within a sub basin of the Nandamojo watershed. This study addressed three hypotheses: (1) sites with low tree cover and small riparian buffer zones will have high erosion, (2) macroinvertebrate abundance will be lower at sites with low channel stability values, and (3) benthic …
Enhanced Control Of Mycobacterium Tuberculosis Extrapulmonary Dissemination In Mice By An Arabinomannan-Protein Conjugate Vaccine, R Prados-Rosales, L Carreno, T Cheng, C Blanc, B Weinrick, Aharona Glatman-Freedman, A Casadevall, S Hung, A Tripathi, J Xu, Aharona Glatman-Freedman, W Jacobs Jr., J Chan, S Porcelli, J Achkar, A Casadevall
Enhanced Control Of Mycobacterium Tuberculosis Extrapulmonary Dissemination In Mice By An Arabinomannan-Protein Conjugate Vaccine, R Prados-Rosales, L Carreno, T Cheng, C Blanc, B Weinrick, Aharona Glatman-Freedman, A Casadevall, S Hung, A Tripathi, J Xu, Aharona Glatman-Freedman, W Jacobs Jr., J Chan, S Porcelli, J Achkar, A Casadevall
NYMC Faculty Publications
Currently there are a dozen or so of new vaccine candidates in clinical trials for prevention of tuberculosis (TB) and each formulation attempts to elicit protection by enhancement of cell-mediated immunity (CMI). In contrast, most approved vaccines against other bacterial pathogens are believed to mediate protection by eliciting antibody responses. However, it has been difficult to apply this formula to TB because of the difficulty in reliably eliciting protective antibodies. Here, we developed capsular polysaccharide conjugates by linking mycobacterial capsular arabinomannan (AM) to either Mtb Ag85b or B. anthracis protective antigen (PA). Further, we studied their immunogenicity by ELISA and …
The Therapeutic Effects Of Dry Cupping On Iliotibial Band Tightness, Madeline Marie Biehl
The Therapeutic Effects Of Dry Cupping On Iliotibial Band Tightness, Madeline Marie Biehl
Theses and Dissertations
Context: The iliotibial band (ITB) is a muscle-like structure on the outside of the thigh and plays a vital role in movement and can become tight if overused. This tightness can lead to a wide array of injuries in an otherwise healthy individual. Previous research has proved the need to treat a tight ITB, but techniques previously researched have not proven to be effective in reducing ITB tightness. Dry cupping is a method in which suction is generated from a vacuum-sealed cup using a pump in order to alleviate pain, reduce tightness, and promote healing. Recently, cupping has been used …
Subterranean Systems Provide A Suitable Overwintering Habitat For Salamandra Salamandra, Monika Balogová, Dušan Jelić, Michaela Kyselová, Marcel Uhrin
Subterranean Systems Provide A Suitable Overwintering Habitat For Salamandra Salamandra, Monika Balogová, Dušan Jelić, Michaela Kyselová, Marcel Uhrin
International Journal of Speleology
The fire salamander (Salamandra salamandra) has been repeatedly noted to occur in natural and artificial subterranean systems. Despite the obvious connection of this species with underground shelters, their level of dependence and importance to the species is still not fully understood. In this study, we carried out long-term monitoring based on the capture-mark-recapture method in two wintering populations aggregated in extensive underground habitats. Using the POPAN model we found the population size in a natural shelter to be more than twice that of an artificial underground shelter. Survival and recapture probabilities calculated using the Cormack-Jolly-Seber model were very …
Nipomo, Diseños 9, Glo 351, Santa Barbara And San Luis Obispo Counties, And Associated Historical Documents
Santa Barbara County
Diseños - Hand-drawn Spanish-Mexican map demonstrating the physical boundaries of land granted to Mexican citizens by the Spanish or Mexican.
Expediente – Hand-written Spanish-Mexican land grant document issued to Mexican citizens in Alta California for land in Alta-California.
Work Progress Administration Abstract (WPA Abstract) – A summary document prepared in 1938 under the Work Progress Administration program detailing the history of a rancho beginning with the Spanish-American land through the U.S. patenting process.
Hoffman Notes -- Summary of information concerning claims made for the Rancho lands from the Appendix containing the Table of Land Claims in the Reports of Land …
Impact Of A National Guideline On Antibiotic Selection For Hospitalized Pneumonia., Derek J Williams, Matthew Hall, Jeffrey S Gerber, Mark I Neuman, Adam L Hersh, Thomas V Brogan, Kavita Parikh, Sanjay Mahant, Anne J Blaschke, Samir S Shah, Carlos G Grijalva
Impact Of A National Guideline On Antibiotic Selection For Hospitalized Pneumonia., Derek J Williams, Matthew Hall, Jeffrey S Gerber, Mark I Neuman, Adam L Hersh, Thomas V Brogan, Kavita Parikh, Sanjay Mahant, Anne J Blaschke, Samir S Shah, Carlos G Grijalva
Pediatrics Faculty Publications
BACKGROUND: We evaluated the impact of the 2011 Pediatric Infectious Diseases Society/Infectious Diseases Society of America pneumonia guideline and hospital-level implementation efforts on antibiotic prescribing for children hospitalized with pneumonia.
METHODS: We assessed inpatient antibiotic prescribing for pneumonia at 28 children's hospitals between August 2009 and March 2015. Each hospital was also surveyed regarding local implementation efforts targeting antibiotic prescribing and organizational readiness to adopt guideline recommendations. To estimate guideline impact, we used segmented linear regression to compare the proportion of children receiving penicillins in March 2015 with the expected proportion at this same time point had the guideline not …
Los Dos Pueblos, Diseños 517, Glo 381, Santa Barbara County, And Associated Historical Documents
Los Dos Pueblos, Diseños 517, Glo 381, Santa Barbara County, And Associated Historical Documents
Santa Barbara County
Diseños - Hand-drawn Spanish-Mexican map demonstrating the physical boundaries of land granted to Mexican citizens by the Spanish or Mexican.
Expediente – Hand-written Spanish-Mexican land grant document issued to Mexican citizens in Alta California for land in Alta-California.
Work Progress Administration Abstract (WPA Abstract) – A summary document prepared in 1938 under the Work Progress Administration program detailing the history of a rancho beginning with the Spanish-American land through the U.S. patenting process.
Hoffman Notes -- Summary of information concerning claims made for the Rancho lands from the Appendix containing the Table of Land Claims in the Reports of Land …
Nojoqui, Diseños 492, Glo 367, Santa Barbara County, And Associated Historical Documents
Nojoqui, Diseños 492, Glo 367, Santa Barbara County, And Associated Historical Documents
Santa Barbara County
Diseños - Hand-drawn Spanish-Mexican map demonstrating the physical boundaries of land granted to Mexican citizens by the Spanish or Mexican.
Expediente – Hand-written Spanish-Mexican land grant document issued to Mexican citizens in Alta California for land in Alta-California.
Work Progress Administration Abstract (WPA Abstract) – A summary document prepared in 1938 under the Work Progress Administration program detailing the history of a rancho beginning with the Spanish-American land through the U.S. patenting process.
Hoffman Notes -- Summary of information concerning claims made for the Rancho lands from the Appendix containing the Table of Land Claims in the Reports of Land …
Las Posas, Diseños 296, Glo 401, Santa Barbara County, And Associated Historical Documents
Las Posas, Diseños 296, Glo 401, Santa Barbara County, And Associated Historical Documents
Santa Barbara County
Diseños - Hand-drawn Spanish-Mexican map demonstrating the physical boundaries of land granted to Mexican citizens by the Spanish or Mexican.
Expediente – Hand-written Spanish-Mexican land grant document issued to Mexican citizens in Alta California for land in Alta-California.
Work Progress Administration Abstract (WPA Abstract) – A summary document prepared in 1938 under the Work Progress Administration program detailing the history of a rancho beginning with the Spanish-American land through the U.S. patenting process.
Hoffman Notes -- Summary of information concerning claims made for the Rancho lands from the Appendix containing the Table of Land Claims in the Reports of Land …
Protein Footprinting Comes Of Age: Mass Spectrometry For Biophysical Structure Assessment, Liwen Wang, Mark R. Chance
Protein Footprinting Comes Of Age: Mass Spectrometry For Biophysical Structure Assessment, Liwen Wang, Mark R. Chance
Faculty Scholarship
Protein footprinting mediated by mass spectrometry has evolved over the last 30 years from proof of concept to commonplace biophysics tool, with unique capabilities for assessing structure and dynamics of purified proteins in physiological states in solution. This review outlines the history and current capabilities of two major methods of protein footprinting: reversible hydrogen-deuterium exchange (HDX) and hydroxyl radical footprinting (HRF), an irreversible covalent labeling approach. Technological advances in both approaches now permit high-resolution assessments of protein structure including secondary and tertiary structure stability mediated by backbone interactions (measured via HDX) and solvent accessibility of side chains (measured via HRF). …
Los Alamos, Diseños 324, Glo 358, Santa Barbara County, And Associated Historical Documents
Los Alamos, Diseños 324, Glo 358, Santa Barbara County, And Associated Historical Documents
Santa Barbara County
Diseños - Hand-drawn Spanish-Mexican map demonstrating the physical boundaries of land granted to Mexican citizens by the Spanish or Mexican.
Expediente – Hand-written Spanish-Mexican land grant document issued to Mexican citizens in Alta California for land in Alta-California.
Work Progress Administration Abstract (WPA Abstract) – A summary document prepared in 1938 under the Work Progress Administration program detailing the history of a rancho beginning with the Spanish-American land through the U.S. patenting process.
Hoffman Notes -- Summary of information concerning claims made for the Rancho lands from the Appendix containing the Table of Land Claims in the Reports of Land …
Apolipoprotein E4 And Insulin Resistance Interact To Impair Cognition And Alter The Epigenome And Metabolome, Lance A. Johnson, Eileen Ruth S. Torres, Soren Impey, Jan F. Stevens, Jacob Raber
Apolipoprotein E4 And Insulin Resistance Interact To Impair Cognition And Alter The Epigenome And Metabolome, Lance A. Johnson, Eileen Ruth S. Torres, Soren Impey, Jan F. Stevens, Jacob Raber
Physiology Faculty Publications
Apolipoprotein E4 (E4) and type 2 diabetes are major risk factors for cognitive decline and late onset Alzheimer’s disease (AD). E4-associated phenotypes and insulin resistance (IR) share several features and appear to interact in driving cognitive dysfunction. However, shared mechanisms that could explain their overlapping pathophysiology have yet to be found. We hypothesized that, compared to E3 mice, E4 mice would be more susceptible to the harmful cognitive effects of high fat diet (HFD)-induced IR due to apoE isoform-specific differences in brain metabolism. While both E3 and E4 mice fed HFD displayed impairments in peripheral metabolism and cognition, deficits in …
Recruitment Of Reviewers Is Becoming Harder At Some Journals: A Test Of The Influence Of Reviewer Fatigue At Six Journals In Ecology And Evolution, Charles W. Fox, Arianne Y. K. Albert, Timothy H. Vines
Recruitment Of Reviewers Is Becoming Harder At Some Journals: A Test Of The Influence Of Reviewer Fatigue At Six Journals In Ecology And Evolution, Charles W. Fox, Arianne Y. K. Albert, Timothy H. Vines
Entomology Faculty Publications
Background: It is commonly reported by editors that it has become harder to recruit reviewers for peer review and that this is because individuals are being asked to review too often and are experiencing reviewer fatigue. However, evidence supporting these arguments is largely anecdotal.
Main body: We examine responses of individuals to review invitations for six journals in ecology and evolution. The proportion of invitations that lead to a submitted review has been decreasing steadily over 13 years (2003–2015) for four of the six journals examined, with a cumulative effect that has been quite substantial (average decline from 56% of …
Data-Driven Identification Of Potential Zika Virus Vectors, Michelle V. Evans, Tad Dallas, Barbara A. Han, Courtney C. Murdock, John M. Drake
Data-Driven Identification Of Potential Zika Virus Vectors, Michelle V. Evans, Tad Dallas, Barbara A. Han, Courtney C. Murdock, John M. Drake
Faculty Publications
Zika is an emerging virus whose rapid spread is of great public health concern. Knowledge about transmission remains incomplete, especially concerning potential transmission in geographic areas in which it has not yet been introduced. To identify unknown vectors of Zika, we developed a data-driven model linking vector species and the Zika virus via vector-virus trait combinations that confer a propensity toward associations in an ecological network connecting flaviviruses and their mosquito vectors. Our model predicts that thirty-five species may be able to transmit the virus, seven of which are found in the continental United States, including Culex quinquefasciatus and Cx. …
The Influence Of Online Social Networking Sites On Selection Into A Dietetic Internship, Noel Lorraine Konken
The Influence Of Online Social Networking Sites On Selection Into A Dietetic Internship, Noel Lorraine Konken
Theses and Dissertations
Background: Acceptance into a Dietetic Internship (DI) Program is a competitive application process where the growing number of applicants exceeds the number of available positions. Because of this, Dietetic Internship (DI) directors may need to outsource external applicant information on social networking sites (SNS) to better differentiate among top candidates.
Objective: The purpose of this study surveying didactic program in dietetics (DPD) directors and DI directors was to evaluate the effects of SNS education on DPD match rate and how DI directors utilize SNS while reviewing potential candidates’ application materials.
Design: DPD and DI directors were emailed a link to …
Meeting Minutes, March 8th, 2017, National Smokejumper Association Board Of Directors
Meeting Minutes, March 8th, 2017, National Smokejumper Association Board Of Directors
National Smokejumper Association Meeting Minutes
Agenda: Call to order.; Introduction to site.; Introductions.; Approval of the agenda.; Approval of previous meeting minutes.; Investment Committee report.; Adopt 2017-18 Budget.; Report on 2016 Trails Program.; Good Samaritan Fund report.; Traveling Smokejumper display.; Membership Report.; Report of partnership possibilities.; Website Committee update.; Scholarship program update.; National Museum of Forest Service History.; NSA website Photo Gallery.; Historic Preservation Program.; Update on the smokejumper program.; Unfinished business.; Evergreen Museum.; the Tennessee Fires.; Evaluation of meeting and travel/lodging vouchers.; Next meeting is scheduled for October 18th in Tukwila, WA.; Evening Social.;
Raising The Bar: At-Risk Prevention For Urban Students In Middle School Science And Math Classrooms, Marilyn Lanier Dr.
Raising The Bar: At-Risk Prevention For Urban Students In Middle School Science And Math Classrooms, Marilyn Lanier Dr.
National Youth Advocacy & Resilience Conference
This presentation illustrates best practices for enhancing student success in Middle School science and math classrooms. The outcome will provide participants with a clear picture of what good teaching looks like when an empowering, experienced teacher implements pragmatic elements of third space theory and culturally responsive pedagogy to reduce the probability for at-risk behaviors in students from urban environments.
Molecular Regulation Of Stem Cell Behavior During Tissue Repair And Cancer Formation, Nestor J. Oviedo
Molecular Regulation Of Stem Cell Behavior During Tissue Repair And Cancer Formation, Nestor J. Oviedo
Science Seminar Series
Oviedo will be presenting his work on identifying the mechanisms of adult stem cell fate determination based on their topographical location in the adult body. Understanding stem cell fate determination is crucial because tissue repair and neoplastic growth are greater in anterior than in posterior regions of adult animals. Despite its critical implications for stem cell biology, carcinogenesis and regenerative medicine, this physiological phenomenon has remained overlooked. Recent findings from his group provide intriguing evidence implying DNA repair mechanisms and cellular signaling through post-translational modifications regulate stem cell fate decision depending on their topographical location in the adult body. We …
Age And Size At First Reproduction In The Channeled Whelk Population Of The Great South Bay, Long Island, New York., Robin Lynn
Discovery Day (formerly Post & Beyond)
The channeled whelk, Busycotypus canaliculatus, is a commercially valuable gastropod found on the east coast of the United States. In New York, the channeled whelk fishery is largely unregulated, due to a lack of knowledge regarding the life history of the species. This study focuses on determining the age and size at first reproduction of the channeled whelk population in the Great South Bay, on the southern shore of Long Island. Whelks were obtained from a commercial fisherman and individually dissected to determine maturity; correlations to shell length and shell width were then examined. The operculum of each individual dissected …
Where Is The Nls In Tip60?, Himali Vashishtha
Where Is The Nls In Tip60?, Himali Vashishtha
Discovery Day (formerly Post & Beyond)
Tip60 is a lysine acetyltransferase (KAT), coded by the KAT5 gene, which is involved in transcription, DNA repair, and apoptosis. It acetylates histones, the ATM protein kinase, and the p53 tumor suppressor, among other targets, making it a key regulator of cell homeostasis. Tip60 has been shown to be a tumor suppressor in most cancers but an oncogene in prostate cancer. Some of Tip60’s functions take place in the nucleus while others occur in the cytoplasm. We were interested in investigating whether the nuclear localization of Tip60 is important for its tumor suppressor function. We hypothesized that decreasing Tip60 nuclear …