Rethinking The 3rs: From Whitewashing To Rights,
2019
Harvard Law School
Rethinking The 3rs: From Whitewashing To Rights, Charlotte E. Blattner
Humane Science Movement Collection
Few other issues have prompted as many legislators to adopt legal instruction on the “proper” use of non-human animals (hereinafter referred to as animals) in medical and scientific research. Today, the 3Rs (replacement, reduction, and refinement of animals in scientific procedures) are globally accepted by a vast majority of states (Blattner, 2014); and prominent international organizations, such as the World Organisation for Animal Health (Terrestrial Animal Health Code, 2018, Article 7(8)(3)) and the Council of Europe (Convention for the Protection of Vertebrate Animals Used for Experimental and Other Scientific Purposes, 1986, Articles 6(2), 7 and 8). Widespread acceptance of the …
Beyond Plausibility Checks: A Case For Moral Doubt In Review Processes Of Animal Experimentation,
2019
Munich School of Philosophy
Beyond Plausibility Checks: A Case For Moral Doubt In Review Processes Of Animal Experimentation, Mara-Daria Cojocaru, Philipp Von Gall
Morality and Ethics of Animal Experimentation Collection
The fact that countries all over the world continue to develop new regulations for experimentation on non-human animals testament that this practice raises many doubts. Our aim in this chapter is to show that one important type of doubt should receive more attention: a particular type of moral doubt that could play a pivotal role in the ethical review of animal experiments. We assume that there are a range of emotions that indicate morally complex or problematic situations. When one or all of these emotions are experienced, we say that someone is experiencing moral doubt. To illustrate this point, we …
Human Wrongs In Animal Research: A Focus On Moral Injury And Reification,
2019
University of Sydney
Human Wrongs In Animal Research: A Focus On Moral Injury And Reification, Jane Johnson, Anna Smajdor
Morality and Ethics of Animal Experimentation Collection
Using arguments derived from the work of Axel Honneth (2006), we show that animal research involves an institutionalized failure to recognize nonhuman animals that not only reifies animals but the human persons engaged in this process, diminishing the scope of their moral agency and causing moral injury. In this chapter, we begin by briefly articulating the harms to animals in research and the more conventional harms to humans that can arise as a result of animal research, before making a case for the ethical damage wrought by the failures of recognition inherent within the system of animal research. We conclude …
Replacing Animal Tests To Improve Safety For Humans,
2019
Safer Medicines Trust
Replacing Animal Tests To Improve Safety For Humans, Kathy Archibald, Robert Coleman, Tamara Drake
Application of Alternative Methods Collection
In this chapter, we propose a new, pragmatic approach that could accelerate the replacement of most, if not all, regulatory animal tests with superior tests based on human biology. We also propose that changes to the requirements for safety testing, issued by the us Food and Drug Administration (fda), must be made in order to enable the use of superior new tests, which are currently disadvantaged by the outdated language of the regulations. But first, it is imperative to establish some level of understanding of the efficacy of existing animal-based methods in order to know whether any possible replacement is …
The Changing Paradigm In Preclinical Toxicology: In Vitro And In Silico Methods In Liver Toxicity Evaluations,
2019
Université du Luxembourg
The Changing Paradigm In Preclinical Toxicology: In Vitro And In Silico Methods In Liver Toxicity Evaluations, Fozia Noor
Application of Alternative Methods Collection
In vitro methods, based on human primary cells, cell lines, and genetically modified reporter cell lines, have greatly expanded the scope of in vitro toxicology. Other significant progress in the area of human-induced pluripotent stem cells (hiPSCs) (Asgari et al., 2010; Schwartz et al., 2014; Shinde et al., 2016; Shtrichman, Germanguz and Itskovitz-Eldor, 2013) is allowing the application of patient and disease-specific hiPSCs (Ghodsizadeh et al., 2010; McCracken et al., 2014; Siller et al., 2013). Moreover, the tools of precise genome editing with engineered nucleases, such as the zinc finger nucleases (zfns), the transcription activator-like effecter nucleases (talens) and, more …
The Potential Of Organ On Chip Technology For Replacing Animal Testing,
2019
Kirkstall Ltd.
The Potential Of Organ On Chip Technology For Replacing Animal Testing, Malcolm Wilkinson
Human Clinical Trials Collection
The term organ on a chip is used to describe the latest stage of development of in vitro cell culture technology. Figure 26.1 shows its steady development since the 1960s. Each step forward has improved our ability to model human-clinical response to new drugs or therapies and has enabled safety risk assessment of existing cosmetics, personal care products, or other chemicals in the environment. Scientific evidence that the predictive power of in vitro tests is superior to the use of animals will trigger a major shift in the way that medical research, in many areas, is carried out. In this …
Recent Developments In Alternatives To Animal Testing,
2019
Cruelty Free International
Recent Developments In Alternatives To Animal Testing, Katy Taylor
Application of Alternative Methods Collection
Methods that replace techniques that use live animals, or methods of testing substances without live animal use, are known as alternatives, replacements or non-animal methods. Some prefer the term advanced technologies given the fact that they often rely on more sophisticated technology and are more human- relevant than the animal test they replace (see Langley et al., 2015). There have been efforts to replace animal tests since the 1960s. Significant progress initially came in replacing animals used to diagnose human disease; to produce biological drugs (such as vaccines); and to safety test batches of these drugs as they were produced. …
Behavioral Research On Captive Animals: Scientific And Ethical Concerns,
2019
Animal Defenders International
Behavioral Research On Captive Animals: Scientific And Ethical Concerns, Kimberley Jayne, Adam See
Morality and Ethics of Animal Experimentation Collection
The first half of this chapter focuses exclusively on animals that are used in laboratory behavioral research to model wild behavior, what is typically involved, problems associated with this practice, and how behavioral research has revealed scientific problems in the animal model. The second half of this chapter then addresses the ethical questions of whether scientific curiosity of animal behavior in general provides any justification for carrying out this research in this first place, with specific focus on non-human primates (nhps).
When Is An Alternative Not An Alternative? Supporting Progress For Absolute Replacement Of Animals In Science,
2019
Lush Prize Management Team
When Is An Alternative Not An Alternative? Supporting Progress For Absolute Replacement Of Animals In Science, Craig Redmond
Humane Science Movement Collection
This chapter addresses some of the areas in which animals are still used within “alternatives”-based research and calls on animal welfare and in vitro organizations to lead the debate and encourage absolute replacement of animal use in research. Without this, progress to end animal research will always remain limited, despite the paradigm shift seen in recent decades.
Research And Testing Without Animals: Where Are We Now And Where Are We Heading?,
2019
Johns Hopkins University
Research And Testing Without Animals: Where Are We Now And Where Are We Heading?, Thomas Hartung
Humane Science Movement Collection
Experiments involving non-human animals (hereinafter referred to as animals) were the predominant technology in the life sciences from the 1920s to the 1970s. Increasingly, animal-based procedures have been complemented and superseded by other approaches; yet, they still have an enormous reputation as an apparent definitive answer to many scientific and, especially, regulatory questions. They have been questioned first for ethical reasons: Can we justify making animals suffer for scientific inquiry? Simply said, people have different views on this question, but the general public views animal experimentation more and more critically. The animal research community has sought a compromise between those …
Ethics, Efficacy, And Decision-Making In Animal Research,
2019
University of California - San Diego
Ethics, Efficacy, And Decision-Making In Animal Research, Lawrence A. Hansen, Kori Ann Kosberg
Morality and Ethics of Animal Experimentation Collection
Few would disagree with the ethical contention that if cruelty to animals is not wrong, then nothing is wrong. In fact, it is not only wrong, but in most states in the us, it is a crime, a felony no less. And yet, intentionally inflicting pain and suffering upon animals, which meets Webster’s definition of cruelty, is routinely countenanced when vivisection (from the Latin vivi, to be alive, and secare, to cut) is performed under license for biomedical research. Deciding to embrace, or reject, or limit animal research demands our best ethical judgment; and it is complicated by factual disputes …
Consequences And Management Of Canine Brachycephaly In Veterinary Practice: Perspectives From Australian Veterinarians And Veterinary Specialists,
2019
University of Sydney
Consequences And Management Of Canine Brachycephaly In Veterinary Practice: Perspectives From Australian Veterinarians And Veterinary Specialists, Anne Fawcett, Vanessa Barrs, Magdoline Awad, Georgina Child, Laurencie Brunel, Erin Mooney, Fernando Martinez-Taboada, Beth Mcdonald, Paul Mcgreevy
Professional Veterinary Ethics Collection
This article, written by veterinarians whose caseloads include brachycephalic dogs, argues that there is now widespread evidence documenting a link between extreme brachycephalic phenotypes and chronic disease, which compromises canine welfare. This paper is divided into nine sections exploring the breadth of the impact of brachycephaly on the incidence of disease, as indicated by pet insurance claims data from an Australian pet insurance provider, the stabilization of respiratory distress associated with brachycephalic obstructive airway syndrome (BOAS), challenges associated with sedation and the anaesthesia of patients with BOAS; effects of brachycephaly on the brain and associated neurological conditions, dermatological conditions associated …
Ethical And Scientific Pitfalls Concerning Laboratory Research With Non-Human Primates, And Possible Solutions,
2019
University of Lisbon, Portugal
Ethical And Scientific Pitfalls Concerning Laboratory Research With Non-Human Primates, And Possible Solutions, Constança Carvalho, Augusta Gaspar, Andrew Knight, Luís Vicente
Morality and Ethics of Animal Experimentation Collection
Basic and applied laboratory research, whenever intrusive or invasive, presents substantial ethical challenges for ethical committees, be it with human beings or with non-human animals. In this paper we discuss the use of non-human primates (NHPs), mostly as animal models, in laboratory based research. We examine the two ethical frameworks that support current legislation and guidelines: deontology and utilitarianism. While human based research is regulated under deontological principles, guidelines for laboratory animal research rely on utilitarianism. We argue that the utilitarian framework is inadequate for this purpose: on the one hand, it is almost impossible to accurately predict the benefits …
The Ethics Of An Unlicensed Medical Practitioner,
2019
Sacred Heart University
The Ethics Of An Unlicensed Medical Practitioner, Charles C. Escott
Writing Across the Curriculum
For option A of this assignment, the prompt is that Harry, a manufacturer of medical equipment and an avid reader of medical textbooks, has developed a program that will allow its users to self-diagnose and self-treat their ailments, without a doctor’s help. Harry wants to sell his program to “ordinary folk” as a replacement for consulting licensed medical practitioners. An important point here is that Harry is not licensed to practice medicine and has only read books on the subject. The posed question is whether or not his program should be published (from an ethical standpoint—not necessarily a profit-driven one). …
Sexual Mutilation Of Muslim Girls, Today In The United States,
2019
Brooklyn College CUNY
Sexual Mutilation Of Muslim Girls, Today In The United States, Robert Brannon
Dignity: A Journal of Analysis of Exploitation and Violence
No abstract provided.
Strategies Healthcare Managers Use To Reduce Hospital-Acquired Infections,
2019
Walden University
Strategies Healthcare Managers Use To Reduce Hospital-Acquired Infections, Yohannes Debesai
Walden Dissertations and Doctoral Studies
Every year, 2 million patients in the United States suffer with at least 1 hospital-acquired infection resulting in an estimated 99,000 deaths annually. The purpose of this exploratory single case study was to explore strategies healthcare managers in U.S. hospitals used to reduce hospital-acquired infections. The study included face-to-face, semistructured interviews with 5 healthcare managers from a hospital in Maryland who were successful in reducing these infections. The conceptual framework was human capital theory. Field notes, hospital documents, and transcribed interviews were analyzed to identify themes regarding strategies used by healthcare managers. The data analysis and coding process resulted in …
Globalization Of Clinical Research And Assessment Of Global Access To Treatments Approved Between 2006-2015,
2019
Walden University
Globalization Of Clinical Research And Assessment Of Global Access To Treatments Approved Between 2006-2015, Rafael Duncan Escandon
Walden Dissertations and Doctoral Studies
Globalization in clinical research and development has increased since the 1990s. Products approved in the United States (U.S.) and European Union (EU) include increasing numbers of research participants from low- and middle-income countries. The purposes of this quantitative correlational study were to investigate the lag time, or drug lag, between U.S. approval and the approval of selected drugs in all countries that hosted their pivotal clinical trials. The study population was limited to products approved first in the U.S. between 2006 and 2015. The health capability model and research for health justice framework were the theoretical frameworks for the study. …
Health For All: Using Utilitarianism To Require Childhood Vaccinations,
2019
Augustana College, Rock Island Illinois
Health For All: Using Utilitarianism To Require Childhood Vaccinations, Hannah Vercellotti
Augustana Center for the Study of Ethics Essay Contest
In the last few decades, many parents have chosen not to vaccinate their children against serious infectious diseases. In seeking exemptions, they often cite conflicting religious beliefs and fear of risks. Using the principle of utilitarianism, this paper argues that despite parents' cited religious beliefs and concerns about risks, state laws should require all children to get vaccinated unless doing so would cause direct harm to the child’s health. Adopting this mandate would ensure that the maximum number of people would benefit from immunity to serious and deadly diseases.
The Bionic Brain: Pragmatic Neuroethics And The Moral Plausibility Of Cognitive Enhancement,
2019
Sacred Heart University
The Bionic Brain: Pragmatic Neuroethics And The Moral Plausibility Of Cognitive Enhancement, Peter A. Depergola Ii
Philosophy, Theology and Religious Studies Faculty Publications
The seemingly infinite possibilities of contemporary neuroscience span from the augmentation of memory, executive function, appetite, libido, sleep, and mood, to the maturation and development of emotional health and personality. These prospects hint at the capacity to alter neurocognitive conceptions of reality. They also mark the unavoidable inculcation of nuanced individual responses, perhaps radical, to these “tailor- made” perceptions. Hence, there exists certain neuroethical, and even more generally, existential risks within this fascinating and expeditious enterprise. The primary question in the context of present-day neurotechnology is not what can be done, but what should be. To that end, this paper …
Florida Adult Trauma Scorecard Methodology And Scene Transportation Choice,
2019
Walden University
Florida Adult Trauma Scorecard Methodology And Scene Transportation Choice, Patricia Maher
Walden Dissertations and Doctoral Studies
Prehospital management of patients who are traumatically injured within the state of Florida starts with the use of the Florida Adult Trauma Scorecard Methodology. The scorecard methodology may indicate that a patient is a Trauma Alert based on applied physiological and other judgment criteria. However, patients may be transported via Helicopter Emergency Medical Services (HEMS) without justified physiological needs. Rawls’ theory of justice posits that a fair and equal distribution of social resources is essential to public wellbeing. To evaluate this premise regarding prehospital trauma transports, archival 2015 data from the Florida Department of Health Trauma Registry was obtained. Using …
