Chemical Engineering Commons^™

Temporal Dynamics Of Extracellular Matrix Remodeling In Anthracycline-Induced Cardiotoxicity, Fibi Meshrkey, Somaya Y. Ibrahim, Rushita A. Bagchi, William J. Richardson

Chemical Engineering Faculty Publications and Presentations

Anthracyclines are widely used chemotherapeutic agents with proven efficacy against a broad range of malignancies, but their clinical utility is limited by a well-documented, dose-dependent cardiotoxicity. While this toxicity has traditionally been attributed to direct cardiomyocyte injury, emerging evidence highlights the pivotal role of cardiac fibroblasts (CFs) in the development and progression of anthracycline-induced cardiotoxicity. This review examines the diverse effects of anthracycline focusing on doxorubicin (DOX) and CFs across the temporal phases of cardiac injury. DOX activates fibroblast-driven extracellular matrix remodeling and promotes fibrosis through enhanced collagen production and the induction of cellular senescence, thereby exacerbating early myocardial inflammation …

Figure Data For "Investigation Of A Stable And Saturated Reference Electrode Using Metal Chlorides And Oxides In Eutectic Licl-Kcl Molten Salts", Carlos Meija, Devin Rappleye

ScholarsArchive Data

This data set provide machine readable .csv files for the figures in the publication entitled "Investigation of a stable and saturated reference electrode using metal chlorides and oxides in eutectic LiCl-KCl molten salts" in Nuclear Engineering and Technology (Volume 58, Issue 1, January 2026, 103875).

Comparative Analysis Of Life Cycle Assessment Of Traditional And Contemporary Timber Buildings, Sadık Akşar, Gökçe Tuna

Journal of Sustainable Construction Materials and Technologies

Wood has long been used as a primary building material, but with the Industrial Revolution and the spread of multi-story structures, its structural limitations became evident. In the 21st century, engineered timber products have reintroduced wood as a sustainable alternative, offering advantages such as lightness, rapid assembly, and recyclability. At the same time, buildings are responsible for significant environmental impacts, making assessment methods essential. Life Cycle Assessment (LCA) is one of the most widely used tools for evaluating these impacts across all stages of a building’s life cycle. This study applies LCA to timber construction systems, focusing on both traditional …

Sustainable Paving Block Development: Utilizing Rejected Coal As Filler And Assessing Its Impact On Paving Block’S Properties, Siti Nikmatin, Allen Kurniawan, Heriansyah Putra, Rima Fitria Adiati, Riawan Ma’Ruf, Dwi Arso Yedi Irwanto

Journal of Sustainable Construction Materials and Technologies

This study investigated the potential use of rejected coal as a fine aggregate filler in paving block production. Comprehensive characterization of the rejected coal was conducted, including toxicity, physical, chemical, and mineralogical analyses of the coal. The results showed that the rejected coal met environmental safety standards (TCLP) and had suitable properties as an aggregate. Paving blocks were produced by incorporating different proportions of rejected coal fillers and were tested for compressive strength, water absorption, and density. The optimal mix with 35% rejected coal filler as a replacement of stone ash achieved a compressive strength of 14.61 MPa, water absorption …

Numerical Comparative Study Of The Thermal Performance And Load-Bearing Capacity Of Hollow Clay Bricks Used In Construction In Libya, Osama Lawej, Mahmoud Ahmed, Ismael Ehtiwesh

Journal of Sustainable Construction Materials and Technologies

The optimization of structural and thermal performance in building components is a key challenge in sustainable construction, particularly in hot climate regions like Libya. Hollow clay bricks are widely used due to their local availability and affordability; however, their internal geometry is often not optimized for thermal resistance or mechanical integrity. This study addresses this gap by numerically investigating the effect of cavity geometry on the load-bearing capacity and thermal insulation performance of hollow clay bricks. Three configurations were analyzed, including two commercial designs from the Libyan market and a newly proposed arched cavity design. Finite Element Method (FEM) simulations …

Developing A Modular Circular Wall Over-Clad System For Facade Thermal Upgrade In Deep Energy Retrofit, Patrick Daly

Journal of Sustainable Construction Materials and Technologies

The EU has implemented several policy and legislative initiatives aimed at decarbonisation and circularity transition of the Built Environment including a strategy for large scale renovation of the building / housing stock. Modularised construction solutions are argued to be a potential acceleration pathway toward this objective. Yet there remains issues and challenges in implementing such strategies in a complex and heterogeneous stock and sector. This research investigates this decarbonisation pathway, examining the feasibility and potential of applying a modularised construction over-clad system, based on advanced circularity, in the deep energy retrofit of social housing. The research is based on a …

Fluorinated Electrolytes For Lithium–Sulfur And Beyond-Lithium Metal–Sulfur Batteries, Avinash Raulo, Saheed Lateef, Hunter Mcray, Kaushek Rahul Ilancheran, Fabio Albano, Golareh Jalilvand

Faculty Publications

Metal–sulfur batteries, particularly lithium–sulfur (Li–S) systems, have attracted significant attention due to their high theoretical energy densities, low cost, and sustainability benefits arising from sulfur’s abundance and non-toxicity. Despite extensive research, their practical deployment remains limited by persistent challenges such as polysulfide shuttling and metal anode degradation, which collectively lead to poor coulombic efficiency and limited cycle life. These issues are further intensified in emerging systems employing sodium, potassium, magnesium, calcium, and siliconbased anodes. Fluorinated electrolytes have emerged as a promising approach to address these limitations. Fluorination enhances oxidative stability, suppresses polysulfide dissolution, promotes stable solid–electrolyte interphase (SEI) formation, and …

Novel Biomolecule-Infused Gelatin Injectable For Treatment Of Recurrent Laryngeal Nerve Injury, Ananya Tadikonda, Sunjay Anekal, Lena W. Chen, Gabriel Sobczak, Troy Wesson, Carmilya Jackson, Marisa A. Egan, Julie C. Liu, Patrick R. Finnegan, Stacey Halum

School of Chemical Engineering Faculty Publications

Objective

Unilateral vocal fold paralysis (UVFP) due to recurrent laryngeal nerve injury (RLN) is a major cause of voice disorders. We have recently identified three biomolecules (agrin, acetylcholine, and neuregulin) with the potential to promote reinnervation after RLN injury. This study aimed to determine if a gelatin injectable with the reinnervating biomolecules will induce site-specific amplification of neurotrophic factor release and reinnervation after RLN injury in unilateral vocal fold paralysis.

Methods

C57BL/6 mice underwent RLN transection with the following treatment allocations: saline control (N = 16), biomolecule cocktail only (N = 16), and biomolecule-infused gelatin (N = …

Coumarin/Nitrogen-Bearing Heterocyclic Hybridloaded Electrospun Pmma/Pvp Nanofibrous Scaffolds For Accelerating Topical Wound Healing Rates: Synthesis And In Vitro Bio-Evaluation, Samar A. Salim, Mohamed Ali, Tasneem Abed, El Badawy Kamoun

Nanotechnology Research Centre

Coumarin-nitrogen heterocyclic compounds (e.g. quinoline, acridine, and phthalazine) were synthesized by facile reactions and elucidated by FTIR, 1H, and 13C-NMR analyses, which showed consistency with the expected structures. Coumarin-quinoline (drug A)- and coumarin-acridine (drug B)-loaded electrospun PMMA/PVP nanofibrous scaffolds were fabricated using electrospinning techniques. Results showed a successful PMMA/PVP blend, which formed the matrix that was used as the main scaffold for drug loading/release. The drugs (A and B) were encapsulated within the matrix as verified by IR and SEM results. Bio-evaluation through cytotoxicity and anticancer screening was conducted using the MTT assay against lung fibroblast (Wi-38), colon carcinoma (Caco-2), …

Superhydrophobic Cerium-Based Metal–Organic Frameworks/Polymer Nanofibers For Water Treatment, Samar A. Salim, Hani Nasser Abdelhamid,

Nanotechnology Research Centre

No abstract provided.

Detecting Electrical Submersible Pump (Esp) Failures And Estimating Run Life Using Artificial Neural Networks, Mostafa Ahmed Sobhy

Theses and Dissertations

Electric Submersible Pumps (ESPs) are one of the important artificial lift methods for sustaining production in mature and high-water-cut wells; but may suffer frequent failures due to mechanical, electrical, hydraulic, chemical, and operational failures. These failures can yield substantial deferred production and intervention costs. Plenty of ESP installations are fitted with downhole sensors. Yet, it is observed that the current industry practice underutilizes the wealth of available sensor and operational data and lacks standardized, explainable failure-type identification and classification.

In this thesis, a comprehensive Machine Learning (ML) and Deep Learning (DL) framework was introduced for ESPs that simultaneously estimates remaining …

Optimizing Beer Fermentation Through Intelligent Control, Azizbek Nodirbekovich Yusupbekov, Mirjalol Yusupov

Chemical Technology, Control and Management

This paper presents an intelligent control approach for optimizing the beer fermentation process using fuzzy logic and adaptive neuro-fuzzy inference systems. By incorporating multivariable inputs—temperature error and pH deviation—the proposed system effectively handles the nonlinear dynamics and biological variability inherent in fermentation. Simulation results demonstrate improved control accuracy, responsiveness, and robustness compared to conventional methods, making the approach suitable for integration in modern brewery automation systems.

Application Of Neural Networks For Intelligent Processing Of Sensor Signals In The Control Of Technological Process Parameters, N.R. Yusupbekov, Yu.Sh. Avazov, G.Kh. Rashidov

Chemical Technology, Control and Management

This scientific article investigates the problem of analyzing technological process parameters in the fields of chemistry, energy, and metallurgy based on sensor data and applying intelligent signal processing methods. The main objective is to evaluate the effectiveness of artificial intelligence and deep learning models for intelligent analysis, forecasting, and anomaly detection of data obtained from sensors. Time-series data collected from industrial sensors were analyzed using LSTM (Long Short-Term Memory) and Autoencoder neural networks, as well as the Kalman filter. At the first stage of the study, sensor signals were denoised and their true state was estimated using the Kalman filter. …

Algorithms For The Synthesis Of Adaptive Control Systems Based On The Speed-Gradient Method, Oxunjon Boborayimov

Chemical Technology, Control and Management

This paper discusses the synthesis algorithms for adaptive control systems based on the speed-gradient method. Adaptive control systems with implicit reference and adjustable models are synthesized using speed-gradient techniques, which reduce the requirements for the main control loop structure and the completeness of measurement data. Stable adaptive decentralized control algorithms are developed for a class of interconnected systems with nonlinear local dynamics and uncertainties, ensuring the stability of individual subsystems and the overall system while accounting for their interactions. To incorporate inter-subsystem interactions into the overall control law, an adaptation algorithm based on the speed-gradient method is introduced. A synthesis …

Finding The Shortest And Optimal Path With Metaheuristic And Madm Methods, Narmin Ibrahim Hasanli

Chemical Technology, Control and Management

The article had described a method for finding the shortest and most optimal path among cities. The data had been taken from the TSPLIB library, which had provided standard examples for the Traveling Salesman Problem. This approach had integrated the advantages of the meta-heuristic technique and the Multi Attribute Decision Making method to solve the problem effectively. In the first stage, the population based meta-heuristic method ACO (Ant Colony Optimization) had found optimal solutions in large search spaces. The use of pheromone trails, heuristic information and an iterative search process had given the opportunity to find the best or near-best …

Modeling Of Urea Drying And Granulation Process In Fluidized Bed, Jalolitdin Pakhritdinovich Mukhitdinov, Aleksey Viktorovich Schulz

Chemical Technology, Control and Management

This article is devoted to the mathematical modeling of urea drying and granulation processes in a fluidized bed. A brief description is provided for the functional blocks included in the mathematical model, along with the required parameters that form an integrated representation of the technological process. The SR-POLAR model is used to describe a phase equilibrium between the components involved. The interconnections between functional blocks are shown in the process flow diagram. Block diagrams for modeling a multi-chamber granulation unit and the cooling system for the resulting granules are presented. Granule growth in the fluidized bed is described using a …

Algorithms For Assessing Soil Salinity Levels Based On Remote Sensing Imagery, Bobomurod Mamitjonovich Tojiboev

Chemical Technology, Control and Management

This article investigates methods for assessing soil salinity levels based on satellite (remote sensing) imagery and their calculation algorithms. Determining the degree of salinity plays a crucial role in the rational use of land resources and increasing agricultural efficiency. The study analyzes indices for determining soil salt content using remote sensing technologies, particularly multispectral images obtained from satellite systems such as Landsat and Sentinel (for example, SI - Salinity Index, NDVI - Normalized Difference Vegetation Index, and others). Furthermore, algorithms are developed based on these indices that enable automatic determination of salinity assessments. Artificial intelligence, machine learning, and geographic information …

Research And Development Of Intelligent Measurement Systems, Odil Abdujalilovich Jumaev, Mahmudov Giyosjon Baqoyevich

Chemical Technology, Control and Management

The article discusses modern methods for developing intelligent measuring systems. Intelligent measuring systems are systems based on intelligent technologies that not only accurately measure physical or chemical quantities, but also have the ability to self-analyze, diagnose and make management decisions. The article comprehensively examines the architecture, components of such systems, the organization of their software and hardware, the relationship of sensors and artificial intelligence algorithms. It also analyzes the practical application and prospects of intelligent measuring systems in such areas as industry, medicine, energy, ecology, transport.

Modern Methods Of Self-Monitoring, Diagnostics, And Fault Tolerance In Flow Measurement Systems, Elbek Ortiqov

Chemical Technology, Control and Management

This article investigates various methods and tools for self-monitoring and fault tolerance in flow measurement transducers used in industrial processes. The study focuses on key techniques such as the use of redundancy, generation of reference values, analysis of measurement signals, and control of disturbance variables. These methods allow transducers to detect potential faults, ensure reliable operation, and maintain measurement accuracy even under adverse conditions. The article highlights how self-monitoring contributes to improving system safety, increasing reliability, and reducing downtime. It also discusses the integration of intelligent monitoring systems that support predictive maintenance and real-time diagnostics. Fault-tolerant sensors with self-monitoring capabilities …

Synthesis Of A Control System For Thermal Energy Facilities Using The Quantum Photon Spin Method, Isomiddin Siddikov, N.S Yakubova

Chemical Technology, Control and Management

Increasing energy efficiency and reducing fuel consumption in the process of generating electricity and heat at thermal power plants is one of the urgent tasks. Such systems operate under conditions of random changes in external and internal influences, as well as measurement uncertainties, which reduce the quality of control. In order to overcome this problem, it was proposed to develop an intelligent control system using the quantum photon-spin method to control technological units of thermal power plants. In the proposed approach, a multi-dimensional heating boiler device was taken as a control object, and the simulation modeling of the control system …

Increasing The Robustness Of A Control System For A Complex Dynamic Plant By Correcting Nonlinearity In The Warping Process, Tukhtamurod Khayitmurodovich Avezov, Zokhid Ergashboyevich Iskandarov

Chemical Technology, Control and Management

The paper discusses the challenges of enhancing the robustness of a control system for a complex dynamic plant by addressing nonlinearity in the warping process. Devices that ensure the stability of the control system against parameter non-stationarity on the warping machine are referred to as state controllers. The operating principle of these devices relies on providing artificial nonlinearity to the rear connection circuit of the control system's actuator. However, this nonlinearity is implemented using components that consider the parameters of low control quality. Therefore, it is necessary to continuously adjust the nonlinearity parameters to, on one hand, reduce the load …

Evaluation Of Deep Learning Techniques In Road Sign Recognition, Latafat Abbas Gardashova, Haji Fakhraddin Hajiyev

Chemical Technology, Control and Management

Deep learning has transformed the computer vision field and greatly improved the performance and efficiency of road sign recognition systems. This research compares different deep learning methods, such as Convolutional Neural Networks (CNNs), Recurrent Neural Networks (RNNs), and hybrid models, in terms of their ability to effectively detect and classify road signs under various conditions. The study compares performance measures such as accuracy, processing speed, and robustness to environmental conditions like low lighting, occlusion, and adverse weather. The results show that CNN-based methods, especially those with transfer learning and ensemble techniques, have better performance in real-time scenarios. Problems like computational …

A C++ Library For Turbulent Mixing Simulation Using Hierarchical Parcel Swapping (Hips), Masoomeh Behrang, Tommy Starick, Heiko Schmidt, David O. Lignell

Faculty Publications

Turbulence models are crucial for simulating flows at all scales, capturing both large-scale structures and small-scale mixing. Software libraries that implement such models should support modular integration, customization, and scalability across different simulation frameworks. This paper presents Hierarchical Parcel Swapping (HiPS), a C++ library documented with Doxygen and available on GitHub. HiPS supports both mixing and reactions and can be used as a standalone model or as a subgrid model in CFD simulations. The code includes examples for users to run it as a standalone model. Additionally, considerations for using it as a subgrid model are provided.

Magnetic Nanoparticles Tethered With Zn–Dpa For The Removal Of Bacteria From Red Blood Cell Suspension, Tochukwu P. Okonkwo, Rajendra P. Gautam, Jacob B. Limburg, Breckin L. Forstrom, Bowen J. Houser, Aaron Rappleyea, Tyler P. Green, Joseph P. Talley, Alexander D. Daum, Stacey J. Smith, Karine Chesnel, William G. Pitt, Roger G. Harrison

Faculty Publications

Bacterial infections continue to drive the need for more effective and rapid methods for bacterial analysis. To address this, magnetic nanoparticles (MNPs) have emerged as promising tools, especially when their surfaces are modified with bacteria binders. The bis-zinc–dipicolylamine (Zn–DPA) complex is known for its broad affinity to bacteria. We have synthesized MNPs via a thermal decomposition method, encapsulated them in silica, modified their surface with Zn–DPA, and tested their ability to remove bacteria. The MNPs retain their superparamagnetic properties and crystallite structure after being encapsulated. The MNPs coated with silica and Zn–DPA effectively bind and remove both Gram-positive and Gram-negative …

Synergetic Adsorptive Mechanisms, Reusability And Cost Evaluations Of Green Fabricated Hybrid Barium Cobalt Nanocomposites For Methylene Blue And Lead Removal From Wastewater, Titus Chinedu Egbosiuba, Chibuike Christogonus Njoku, Ijeoma Jacinta Ani, Godwin Ifeanyi Ogbuehi, Abdulkareem Omeiza Yusuf, Abiodun Azeez Saka, Ugochukwu Ewuzie, Ebuka Emmanuel Ezennajiego, Blessing Onyinye Okafor, Walter Chibuike Anene, Cecilia Chika Unegbu, Florence Acha, Monday Uchenna Okoronkwo

Chemical and Biochemical Engineering Faculty Research & Creative Works

Barium nanoparticles (BaNPs), cobalt nanoparticles (CoNPs), and hybrid barium-cobalt nanocomposites (BaCoNCs) were synthesized using an eco-friendly green technique with Anacardium occidentale leaf extract for sequestration of methylene blue (MB) dye and lead (Pb (II)) ions from industrial wastewater. The nanoparticles and nanocomposites were characterized using Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), high-resolution scanning electron microscopy (HRSEM), and Brunauer-Emmett-Teller (BET) analysis to assess their functional groups, crystalline structure, morphology, and surface properties, confirming successful synthesis. Batch adsorption studies showed that optimal pollutant removal occurred at pH values of 8 for MB and 5 for Pb(II), with a contact time …

Identification Of Flow Regime In A Co-Current Upflow Packed Bed Reactor (U-Pbr) Using Gamma-Ray Densitometry (Grd), Youssef Yatimi, Ahmed Alalou, Muthanna H. Al-Dahhan

Chemical and Biochemical Engineering Faculty Research & Creative Works

Owing to their significant impact on the reaction rate, the comprehensive understanding of the hydrodynamics in any novel design of the Upflow Packed Bed Reactor (U-PBR) is essential for the optimization of its throughput. In this regard, the identification of the flow regime is of paramount importance. Therefore, in this work, we use the photon counts time-series data obtained using the non-invasive Gamma-ray densitometry (GRD) to identify, for the first time, the flow regimes and their transition velocities at two axial locations (Z/D=0.8,1.56) and five radial locations (r/R=0,±0.5,±0.9) within the packed catalysts' bed of U-PBR with a novel plenum design …

Predicting Groundwater Withdrawals Using Machine Learning With Limited Metering Data: Assessment Of Training Data Requirements, Dawit Asfaw, Ryan G. Smith, Sayantan Majumdar, Katherine Grote, Bin Fang, B. B. Wilson, V. Lakshmi, J. J. Butler

Geosciences and Geological and Petroleum Engineering Faculty Research & Creative Works

The future of major aquifer systems supporting irrigated agriculture is threatened due to unsustainable groundwater pumping. Metering of pumping is key for implementing robust groundwater management, but metering is limited in most aquifers. Although machine learning methods have been used to estimate pumping over certain regions, these studies have not fully demonstrated the data quantity and input parameter requirements to accurately estimate regional groundwater pumping. This study determined the data quantity required and identified relevant features to develop Random Forests-based annual groundwater pumping estimates (2008–2020) over the Kansas High Plains aquifer. We predicted pumping at two spatial scales, i.e., point …

Systematic Hazard Analysis Of Flare System Nodes In Chemical Process Safety, Hayder A. Alhameedi, Athmar A. Alzubaidi, Joseph D. Smith, Doug Allen, Saud Aldawood, Paul Ani

Chemical and Biochemical Engineering Faculty Research & Creative Works

Multidimensional consequences may arise from an accident in the flare system of any chemical or petrochemical plant due to the improperly managed flare system, which can lead to the presence of the toxic and flammable gases. The Hazard and Operability Study (HAZOP) is a systematic method used to assess and identify risks that can occur during operation, ensuring risk reduction and the safety of using equipment or units. This study aims to apply the HAZOP technique to identify the hazards associated with the gas flaring process in an air-assisted flare. The air-assisted flare system was subdivided into four sections (nodes), …

Effect Of Short-Chain Polymer Binders On The Mechanical And Electrochemical Performance Of Silicon Anodes, Fei Sun, L. Zurita-Garcia, Dean R. Wheeler

Faculty Publications

Polymer binders are crucial components in providing both mechanical support and chemical stability to the structure of porous Li-ion electrodes. Particularly in silicon anodes, the active material undergoes substantial volume expansion of up to 275%. Due to the mechanical constraint of the current collector, these silicon materials tend to expand in the normal direction while exhibiting substantial particle rearrangement and plastic deformation. Conventional rigid binders such as polyacrylic acid (PAA) and polyimide (PI), while providing satisfactory initial capacity, do not eliminate diminished long-term performance. Our research attempts to develop binder formulations that can accommodate sufficient flexibility for the substantial volume …

Recent Advances In The Design Principles Of Lithium Selective Membranes, Shayan Abrishami, Huan Xiao, Mohsen Asadnia, Ze Xian Low, Amir Razmjou

Research outputs 2022 to 2026

The growing demand for lithium in energy storage applications has intensified the need for efficient lithium extraction technologies, with membrane processes emerging as a promising approach. Among various membrane technologies, nanostructured membranes with precisely engineered channels have shown exceptional potential for selective lithium extraction due to their ability to control ion transport at the molecular level. This review provides a comprehensive analysis of the fundamental design principles governing lithium-selective membranes, with a specific focus on nanochannel-based systems. We examine the critical parameters that influence lithium selectivity, including surface charge distribution, nanochannel dimensions, morphology, and wettability, while exploring how these factors …